LOCUS       reptomyces_RBGC_334022 16763 bp    DNA              BCT 09-SEP-2019
DEFINITION  RiPPTIDE predicted RiPP gene cluster.
ACCESSION   Streptomyces_RBGC_334022
VERSION     Streptomyces_RBGC_334022
KEYWORDS    RiPPs; RiPPTIDE.
SOURCE      GCF_001541145.1
  ORGANISM  GCF_001541145.1
            .
FEATURES             Location/Qualifiers
     CDS             2..4221
                     /protein_domains="PF02518"
                     /protein_domains="PF00072"
                     /protein_domains="PF13185"
                     /protein_domains="PF00512"
                     /protein_domains="PF00672"
                     /protein_domains="PF00672"
                     /protein_domains="PF00672"
                     /protein_domains="PF00672"
                     /protein_domains="PF00672"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044772"
                     /pseudo=False
                     /translation="MAAGTAGEKARPVARTARTEVKVGEPELRQLLAGLTAVRDGNFGT
                     RLPGDADGLLGEIATVFNGMVDQLSLFTSEVTRVAREVGSEGRLGGQAQVPGVSGTWAD
                     LTDSVNAMAGNLTSQVRDIAQVATAVAKGDLSQKIDVDAQGEILELKNTVNTMVDQLSS
                     FADEVTRVAREVGSEGRLGGQAQVPGVGGTWRDLTDSVNFMAGNLTSQVRQGRPLAEDH
                     RGRPGRDPGAEDHGEHDGGPAVRLRRRSHARRPRGRHRGTARRAGPGARSGRNLARPDR
                     LRQLHGREPHLAGVSQKITVDARGEILELKNTINTMVGQLSAFADEVTRVAREVGTEGN
                     LGGQATVRGVSGTWKDLTDNVNVMASNLTGQVRSIAQVAAAVAKGDLSQKITVEAKGEV
                     AALAGVINTMVDTLSAFADEVTRVAREVGTEGMLGGQARVPNVAGTWKDLTDNVNSMAN
                     NLTGQVRNIAQVTTAVANGDLSKKIDVDARGEILELKTTINTMVDQLSSFASEVTRVAR
                     EVGSEGRLGGQAEVEGVSGTWKRLTENVNELAGNLTRQVRAIAGVTSAVAEGDLTRSIT
                     VDASGEVAELKDNINSMVRSLRETTRANQEQDWLKSNLARISGLMQGHRDLAVVAELVM
                     DELTPLVSAQYGAFYLAEETERGTVLRLVGAYGCPPGSTAPDRFGLGESLVGQAARSRR
                     TIVADGVPGDYISISSGLGRTAPGSLIVLPIIVEDQVLGIIELASFTSFTPVHRDFLEQ
                     LMEMVGVNVNTIVANARTDELLEESQRLAGELQARSGELTRQQEELQRSNEELEEKAEL
                     LASQNRDIETKNLEIEQARQELEDRARQLALASKYKSEFLANMSHELRTPLNSLLILAQ
                     LLAQNPTRNLTPKQVEYAGIIHSAGSDLLQLINDILDLSKVEAGKMDINPERVALRQLL
                     DYVEATFRPMTTQKSLDFTISAAPGVPVDLLTDDARLRQILRNLLSNAVKFTEEGSVEL
                     RIEPAADSELPDTVRRGGPVVAFRVKDTGIGIPEQQLAVIFGAFQQADGTTSRKYGGTG
                     LGLSISREIAHLLGGAVTAESTPGLGSAFTLYLPVARADFQEQAGGPAAVEASAGEWGT
                     GRESRPHSPAAEPAPPRRLLVIEERPRGLLSHVAESAVAELAGGGQDLGDRPETIEVVS
                     AVGAQEAAGALAAEPFHCVVLDLDMAGGEALRFLEAMDGDAAVRTVAVLAHNSRRLEAE
                     QERTLQARARTQPLEVLSSLDELRERIALHLSAEQPGDVLPLVRPEEPQAPQPVDDSLS
                     GRTVLVVDDDARNLYALSGILELHGIHVRHAENGREGIQALTEHPDIDLILMDVMMPEM
                     DGYAATAEIRRMPEHARLPIIAVTAKAMPGDREKSLASGASDYVTKPVDTDDLIACVRR
                     WLAS*"
     CDS             4302..6805
                     /protein_domains="PF07228"
                     /protein_domains="PF08447"
                     /protein_domains="PF03861"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044773"
                     /pseudo=False
                     /translation="MSPFEHVGAPSGDDGSPASEDGAGQGPSVPGGLPAPTGPERDPGP
                     TGARPDRTSAVGRLAATVARLRSEVQAAHAAADGRALIELAKGIMVERLRCGPAQATRQ
                     LAELAEKAAVSQLELAVDIINQAARDRVAEVAGDFLHRTRTEPAGTGPADAAGATVGVR
                     LRTAESAALAAGDAQAVADSLLQHALTPLGATAVAIWTAGSDTSLTLAGHAGFPADEAV
                     RWRYVPPGVVTVARQALTERDTVRFASLSETGIPSIGRTHHPHGGRVALPAGTGGRIHG
                     VLEICWQQPLPPQPPVIMRQIEALAELCAHALETTPAVYGHGPAPAQRVPAVAELVDLA
                     DGLHDPALVLTPHLGPDGELTDFRIHHVNGRFMDPAGRPPHTPGGALLLEAYPMAADES
                     ELFDKVQRVYATGEPFRAQRMTLTALVDQVPLAAVADISVSRHGDSVLLIWRIEDETAR
                     LASLLQHAQRLGRIGGFEENLLTDEITWNGQLFALYGRPPTGTPVSLRELAAHAHPDDG
                     IAIGRFLRAVLHHQRSASAAFRLQRPDGVTRHIRVIAEPVHDAEGSLLAVRGAYQDISA
                     QHWTEVALAATRDQLAHTEQESAERNRLALQLQQAIMPPTRGPIAAPGLQIAVRYRPAE
                     TESLVGGDWYDAVVLPSRRVLLCVGDIAGHGIEAATGMVVLRNALRGLAITGAGPAQLL
                     SWLNIVAHHLTDQVTATAVCGLYDPGTRTLRWARAGHLPPVLVRGREATRLPLVGGLLL
                     GAVAQATYEEAELQLEADDTLLMYTDGLVERRDTAIHDSLAQLLATAQSPAPTLEHRLD
                     QLLTHSKSDTDDDTCLVGIQVV*"
     CDS             7200..7390
                     /protein_domains="TIGR04268"
                     /SVM_predicted_precursor=True
                     /locus_tag="prodigal_7044774"
                     /pseudo=False
                     /translation="MTNTYLPGQPSEAQLPDFSALPLGELASRTEHPVLGTLLPGVCER
                     LEDPGSAVAFYDDAPPVA*"
     CDS             7388..8574
                     /protein_domains="PF04055"
                     /protein_domains="TIGR04269"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044775"
                     /pseudo=False
                     /translation="VSEAVRPVPFRQFVLKVHSRCNLACTYCYVYEGPDQSWRERPVRV
                     AERTMRRTAERIAEHVAAHGLRSIRIDLHGGEPLLAGPAALIAYAQTVRDALPHHCSVA
                     VSVQTNGTLLTAGILKQLSAAGITVGLSLDGGSARLNRRRIDRAGRSSWPSVRRAAGLL
                     ADAPASYGGILCTIDVDTDPGEIYRSLVALGPPSLDFLLPYGNWSEPPPGIGPFAGPGC
                     RAARPVPYGHWLAHVFDLWWDTPSGHPPVQVRLFGEIVALLLGAASRTETVGLSPLAVV
                     VVDTDGSIQRVDSLKTAYAGAPDLEMDVFRNDFEDALHHPDTVAAQMRGLVTLCDSCRS
                     CPVVGVCGGGRYTDRYVHGTGFDHPSVYCADLEYLIRHIGDRLRQAVCKERAHVE*"
     CDS             8609..9129
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044776"
                     /pseudo=False
                     /translation="MPYGITLFRRLPGRTLSETLDHRAAAWDGDVDFERSPMNLTPDRR
                     AAWDEIVRRVSAEIGPVSVEEYPYNLTLERNGPVGRIQLDYDGDSAEIEFAYRHFGEAA
                     RQIVVEAYRLAAIVEDVTGLVGFDCQTERPTAEGDIDAAAALLGGISHWARTEIPRMLA
                     EDRPGTGPRN*"
     CDS             complement(9188..10857)
                     /protein_domains="PF05746"
                     /protein_domains="PF03485"
                     /protein_domains="PF00750"
                     /protein_domains="PF00750"
                     /protein_domains="TIGR00456"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044777"
                     /pseudo=False
                     /translation="MTPADLAAVISDGVHTAIRSGLLSAEVSVPEEIRVERPRHRHHGD
                     YSTNVALRLAPAAGLPARTVAEVIAPLVSAADGIAKAEVAGPGFLNITLESGVLGALAR
                     AIVLARDAYGRTDRLGGVRLNLEFVSANPTGPVHIGGARWAVVGDVLARLLEAAGADVA
                     REYYFNDAGVQIDRFARSLLAAAQGSPVPRDGYGGAYIEEIAAAVVRRRPGVLELSDSA
                     AALAVFRAEGTALMFDEIKASLAAFGTRFDVFFNEKDLHDRGDLDAAVVRLREGGHVFE
                     EAGALWLRTTDFGDDKDRVLVKSDGSWTYFTADCAYYLNKRSRGFERVVIMLGADHAGY
                     VGRMRAMAACFGDDPDTHLEILIGQLVNLVRDGEPVRMSKRAGTVVTLDDLVEAVGVDA
                     ARYALARVSVDAVIDLDIDLLTRQSNDNPVYYVQYAHTRLCAVQRKAREAGIDKGAPQD
                     FDPCLLTHPRETVLLGMLAEFPQVVAGAATLREPHRVAHYLEALAATYHRFYDACRVLP
                     RTGEAPDDRTRARLWLTEASRVVLSNGLRLLGVSAPERM*"
     CDS             complement(10968..11161)
                     /SVM_predicted_precursor=True
                     /locus_tag="prodigal_7044778"
                     /pseudo=False
                     /translation="MQHSTNTPDGAAAARQAKFGKLPERIPYEDMVTEKAVSENRAQNT
                     YNPEGSWNHFSCLALDLGL*"
     CDS             complement(11245..12353)
                     /protein_domains="PF00561"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044779"
                     /pseudo=False
                     /translation="MINRRTFGKAMALGTGAAAVSLTGPQAAPVAAAPRSGRSASGPST
                     SGSKSAPGRTSASALPDIAPGTHTTFDRMRHVAAGLLNVGYAEAGPAHGPVVICLHGWP
                     YDIHSFVDVAPLLASRGYRVIVPYLRGHGSTRFRSAATFRNAQQSAVALDIVALMDALG
                     IHRAVLAGFDWGTRTADIIAALWPERVKALVSVSGYLITNVEAQQEPLPARAEHTWWYQ
                     YYFSTERGRRAMEDADKRRELCRLVWETVSPTWDFDDATFARTAMAFENPDYADIVIHN
                     YRWRLGLAEGERRYDRYEKRLAGRPFITVPTITLDPERDPFTAPGNGSSYRDRFTGAYE
                     HRTLTGIGHNLPQEAPTAFAQAVVDVDHF*"
     CDS             complement(12442..12617)
                     /SVM_predicted_precursor=True
                     /pseudo=False
                     /translation="MLLPACGAGGRGWLESICWAERARGGAELAEPVNAWPVADPNPSG
                     PRAMGTLPRSSPS"
     CDS             complement(12668..12831)
                     /SVM_predicted_precursor=True
                     /pseudo=False
                     /translation="MPDRYGTQLAFVPYRWNFGQVEWRGDLAFVSWWGGVWPACVWCAG
                     SGTGGVVGA"
     CDS             12865..13283
                     /protein_domains="PF07883"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044780"
                     /pseudo=False
                     /translation="MIDRHPPLHSSSTTTTTPDPPPAPPARLPSSDPMSGVTRSELQRH
                     PSPAKGWLTVQTVVEIPQHKESGRHSHPGVEVGYIVRGDVLMEFDDGPAQRLRTGDPFF
                     IPSGMIHNARNVGTVTTMMLSTYVIDETKPLVTTY*"
     CDS             13376..13941
                     /protein_domains="PF00440"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044781"
                     /pseudo=False
                     /translation="MTSSASGTIHPRERLLNIAGKLFYANGIHTVGVEQLVREAGVTRA
                     TFYRHFAGKEGLVVAYLQERDARVKRAVEAILRAHRGRDALLEIVAMIADTVLRPEFRG
                     CGFLNAAAEYPDPRHHVRLCVAEHRDWFRGVLRDVAHDAGHPDPDRAARALMVLRDGAM
                     AAGYLDDPHDVARTLREAAESILDA*"
     CDS             14069..14442
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044782"
                     /pseudo=False
                     /translation="MTTKFTRFAAVTGGVLASGLLMLGAAGSPAGAAELPGVTFYTGAN
                     ATGSAVEADLGKVGVCQELTTPVRSFRAVADRSVEVYFNAGCRPGAPGTNGDLVFVVGS
                     LNSGDLPYPGVSYRVRANAG*"
     CDS             complement(14440..15011)
                     /protein_domains="PF07336"
                     /protein_domains="PF11706"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044783"
                     /pseudo=False
                     /translation="MVTVNLDHVFVCGHPALDFAATLRARRSLRFEMFAAPDRLDAWYV
                     ESGIVDSVAPSRPSDVERAKAVREAVYELITARRLGEPFGDRALEVLNAAARKPAAAPQ
                     LTRTGRRTDATSQEALSAVARQAVELLSGPDVPLLKECGNPECTRVYIDRSRGMRRHWC
                     GMESCGNKIKAAAYRARKKSAPATAAG*"
     CDS             complement(15046..16763)
                     /protein_domains="PF00005"
                     /protein_domains="PF00005"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_7044784"
                     /pseudo=False
                     /translation="MPRPALLAHDLVRTLDTRRILDGVSLTAAPGHRVGLIGENGVGKS
                     TLLRLLAGVDEPDAGQVTRPDDLGFLHQEMPFAGDATIARVLDDALREARTDLAELDRL
                     TRLLADTPEDRPAHAELLETYGQRLEQAQEREAWDADRRAAIVLDGLGLGGIAHDRTLG
                     SLSGGQRGRLALAALLVRRPAALLLDEPTNHLDDEAAAFVEGRLRELPGVVVVASHDRA
                     FLDAVCTELIDLDPAVDGPVRFGGNYSAYQAEKRAERERWERRYAEEQEELEELRRSAG
                     VTAHRVAPDRGRRDNEKMGYGHRAGRVQQQISRRVRNATRRLEELERTQVGEPPRPLRL
                     HVGAVAVEVKGTEEAGKTAEPAELVDAPLVELRNVRVPGRLYLDRLDVPSGDRLLVTGG
                     NGAGKSTLLSLLAGRLRAEGEVRRRPGLSVGLLAQDTTFERPDRTARDTYTYVLGAERA
                     EAVPLGSLGLLHAADLGKPVGQLSVGQRRRLTLALLVARPPHLLLLDEPTNHLSPRLCD
                     ELEDALGPGPGTIVVASHDRWLRGRWNGRRLHLSSGRAHADESGEARPKGRPLCR*"
ORIGIN
        1 atggctgctg gaacggcggg cgagaaggcg cgaccggtgg cgcggacggc gcgcaccgag
       61 gtgaaggtcg gggagccgga gctgcgccag ctgctcgccg ggctcaccgc cgtacgcgac
      121 gggaacttcg ggacccgtct gccgggcgac gccgacgggc tgctcgggga gatcgcgacc
      181 gtcttcaacg gcatggtcga ccagctgtcc ctgttcacct cggaagtgac ccgggtggcg
      241 cgcgaggtcg gcagcgaagg ccggctcggc ggccaggcgc aggtgccggg cgtctcgggc
      301 acctgggcgg atctgaccga ctcggtgaac gccatggccg gcaacctcac ctcccaagtg
      361 cgcgacatcg cgcaggtggc caccgccgtc gcgaagggcg acctgtcgca gaagatcgac
      421 gtcgatgccc agggcgagat cctggagttg aagaacaccg tcaacacgat ggtggaccag
      481 ctctcctcgt tcgccgacga ggtcacgcgc gtggcgcgcg aggtcggcag cgaagggcgg
      541 ctcggcgggc aggcccaggt gcccggagtg ggcggaacct ggcgcgacct gaccgactcc
      601 gtcaacttca tggccgggaa cctcacctcg caggttcgcc aagggcgacc tctcgcagaa
      661 gatcaccgtg gacgcccggg gcgagatcct ggagctgaag accacggtga acacgatggt
      721 ggaccagctg tccgccttcg ccgacgaagt cacgcgcgtc gcccgcgagg tcggcaccga
      781 gggacggctc ggcgggcagg cccaggtgcc cggagtgggc ggaacctggc gcgacctgac
      841 cgactccgtc aacttcatgg ccgggaacct cacctcgcag gtgtgtcgca gaagatcacg
      901 gtggatgccc gcggtgagat cctggagctg aagaacacca tcaacacgat ggtcggccag
      961 ctctccgcct tcgccgacga agtcacgcgc gtcgcccgcg aggtcggcac cgagggcaac
     1021 ctcggcggcc aggccaccgt acggggcgtg tcgggcacct ggaaggacct gaccgacaac
     1081 gtcaacgtga tggcctccaa cctgaccggc caggtgcgtt ccatcgccca ggtggccgcg
     1141 gcggtcgcca agggcgatct ctcgcagaag atcacggtcg aggcgaaggg cgaggtggcc
     1201 gcgctcgccg gtgtgatcaa cacgatggtc gacacgctct ccgcgttcgc cgacgaggtc
     1261 acgcgcgtcg cccgcgaggt cggcaccgag ggcatgctcg gcggccaggc ccgcgtaccg
     1321 aacgtggccg gtacgtggaa ggacctgacc gacaacgtca actcgatggc caacaacctg
     1381 accggtcagg tgcgcaatat cgcccaggtc accaccgcgg tcgccaacgg tgacctgtcg
     1441 aagaagatcg acgtcgatgc ccggggcgag atcctggagc tcaagaccac catcaacacc
     1501 atggtcgacc agctctcctc gttcgcctcc gaggtcaccc gggtggcccg cgaggtcggc
     1561 agcgaaggac ggctcggcgg ccaggccgag gtcgagggcg tatcgggcac ctggaagcgg
     1621 ctgaccgaga acgtcaacga gctggccggc aacctcaccc ggcaggtacg ggccatcgcc
     1681 ggggtgacca gcgcggtcgc cgagggcgat ctgacccggt ccatcacggt ggacgcctcc
     1741 ggcgaggtcg cggagctcaa ggacaacatc aactccatgg tgcggtccct gcgcgagacc
     1801 acccgggcca accaggagca ggactggctc aagagcaatc tggcccgcat ctccgggctg
     1861 atgcagggcc accgggacct cgcggtcgtc gccgagctgg tcatggacga gctgacgccg
     1921 ctcgtctcgg cccagtacgg cgccttctac ctggccgagg agaccgagcg cggcaccgta
     1981 ctgaggctcg tcggcgcgta cggctgtccc cccggcagca ccgcgcccga ccggttcgga
     2041 ctgggcgagt cgctggtcgg ccaggccgcg cgcagccgcc gtacgatcgt cgcggacggc
     2101 gtgccgggcg actacatcag catctccagc ggcctgggcc ggacggcgcc gggcagcctg
     2161 atcgtgctgc cgatcatcgt ggaggaccag gtcctcggca tcatcgagct ggcgtccttc
     2221 acctccttca cccccgtgca ccgggacttc ctcgaacagc tcatggagat ggtgggcgtc
     2281 aacgtcaaca ccatcgtcgc caacgcgcgt accgacgagc tgctggagga gtcgcagcgc
     2341 ctggccgggg agctgcaagc gcgctccggg gagctgacgc ggcagcagga ggagctccag
     2401 cgctccaacg aggagctgga ggagaaggcc gaactgctcg cctcccagaa ccgcgacatc
     2461 gagaccaaga acctggagat cgagcaggcg cggcaggagc tggaggaccg ggcgcggcag
     2521 ctggcgctgg cgtcgaagta caagtcggag ttcctggcca acatgagcca cgagctgcgc
     2581 actccgctca acagcctgct catcctggca cagctgctcg cgcagaaccc gacccgcaac
     2641 ctcacgccca agcaggtgga gtacgcgggc atcatccact ccgcgggctc cgacctgctc
     2701 cagctcatca acgacatcct cgacctgtcg aaggtcgagg cgggcaagat ggacatcaac
     2761 ccggagcggg tggcgctgcg gcagctcctg gactacgtcg aggcgacgtt ccggccgatg
     2821 acgacccaga agagcctcga cttcacgatc agtgccgcgc ccggcgtccc ggtggacctg
     2881 ctgaccgacg acgcccggtt gcgtcagatc ctgcgcaatc tcctgtccaa tgcggtcaag
     2941 ttcaccgagg agggcagcgt cgagctgcgg atcgagcccg ccgccgacag tgaactgcct
     3001 gatacggtgc gccgcggtgg ccccgtcgtc gccttccgcg tcaaggacac cggtatcggc
     3061 atcccggagc agcagctcgc ggtgatcttc ggggcgttcc aacaggcgga cggcaccacc
     3121 agccgcaagt acgggggcac cggcctcggc ctgtccatca gccgcgagat cgcccacctc
     3181 ctgggcggcg cggtgacggc cgagagcaca ccggggctgg gcagcgcctt caccctgtat
     3241 ctgcccgtgg cccgcgccga cttccaggag caggccggcg ggccggcggc cgtcgaggcg
     3301 tcggcgggcg agtggggtac ggggcgcgag agccggccgc actcccccgc cgccgagccc
     3361 gcgccgccgc gccggctgct ggtgatcgag gagcgtcccc gcgggctgct ctcccacgtg
     3421 gccgagagcg cggtcgccga gctggccggg ggcggccagg acctgggcga ccgcccggag
     3481 accatcgagg tcgtctccgc ggtcggcgcc caggaggccg ccggagcgct ggccgctgag
     3541 cccttccact gcgtggtcct ggacctggac atggcgggcg gcgaggccct gcggttcctg
     3601 gaggcgatgg acggcgacgc cgccgtacgc accgtcgccg tcctcgccca caacagcagg
     3661 cgtctggagg cggagcagga acgcaccctg caagcacgtg cccgtaccca gccgctggag
     3721 gtcctctcca gcctggacga actgcgcgaa cgcatcgcct tgcatctgtc cgccgagcag
     3781 cccggtgacg tgctgccact ggtacgcccg gaggagccgc aggccccgca gcccgtcgac
     3841 gacagcctca gcggccgcac cgtcctggtc gtggacgacg acgcccgcaa cctgtacgcg
     3901 ctcagcggca tcctggaact gcacggcatc cacgtccggc acgcggagaa cggccgggag
     3961 ggcatccagg cgctcaccga acacccggac atcgacctca tcctgatgga cgtgatgatg
     4021 cccgagatgg acggctacgc cgcgaccgcg gagatccggc ggatgccgga acacgcccgg
     4081 ctgcccatca tcgcggtcac ggccaaggcc atgcccgggg accgggagaa gagcctggcc
     4141 tccggagcca gtgactacgt caccaagccg gtggacaccg acgacctgat cgcctgcgtc
     4201 cgccggtggc tggcctcctg agggggcgtg cccggccggc cgggcacatc cgggccccgc
     4261 gcacgcgccg cactcaccgc atcgaggaat cgacaggatc atgagccctt tcgagcacgt
     4321 cggagccccg tcaggggacg acgggtcgcc ggcgtccgag gacggggcgg gccagggccc
     4381 gtccgtaccg ggcggcctgc ccgcgccgac cgggccggag cgcgaccccg gccccaccgg
     4441 cgcccggccg gaccggacgt ccgccgtcgg ccggctggcc gccacggtcg cgcgcctgcg
     4501 cagcgaggtc caggcggcgc atgcggcggc cgacggacgt gcgctgatcg aactcgccaa
     4561 gggcatcatg gtcgaacggc tgcgctgcgg accggcccag gcgacgcggc agctggccga
     4621 actcgcggag aaggccgcgg tctcccagct ggagctggcc gtggacatca tcaaccaggc
     4681 ggcccgcgac cgggtggcgg aggtcgccgg cgacttcctg caccgcaccc gtaccgagcc
     4741 cgccgggacg ggcccggccg acgcggcggg cgcaaccgtc ggagtgcgcc tgcgtacggc
     4801 cgagagcgcg gccctggccg ccggtgacgc gcaagccgtc gccgactcgc tccttcagca
     4861 cgcgctgact ccgctcggcg ccacggccgt cgccatctgg accgcgggct cggacacgtc
     4921 cctcaccctg gccggtcacg cgggctttcc cgccgacgag gcggtgcgct ggcggtacgt
     4981 gccgccaggc gtggtcaccg tcgcccgcca ggcgctgacc gagcgcgaca ccgtacggtt
     5041 cgcctccctg tccgagacgg gcatcccctc gatcggccgt actcaccacc cgcacggcgg
     5101 ccgcgtggcg ctccccgccg gcaccggcgg ccgtatccac ggcgtgctgg agatctgctg
     5161 gcagcagccg ctgcccccgc agccgcccgt gatcatgcgc cagatagagg cgctggcgga
     5221 actgtgcgcc cacgccctcg aaaccacccc cgccgtgtac gggcacggcc ccgcccccgc
     5281 ccagcgcgtc cccgccgtgg ccgaactggt ggacctggca gacggactcc acgaccccgc
     5341 cctcgtcctc accccccacc tcgggcccga cggcgagctg accgacttcc gcatccacca
     5401 cgtcaacggc cgcttcatgg acccggcggg ccgccccccc cacaccccgg ggggtgccct
     5461 cctcctggag gcgtacccga tggccgccga cgagagcgag ctgttcgaca aggtccagcg
     5521 cgtctacgcc accggagagc ccttccgcgc ccagcggatg accctgaccg ccctggtgga
     5581 ccaggtaccc ctggccgccg tcgccgacat cagcgtcagc cgccacgggg acagcgtgct
     5641 gctcatctgg cgcatcgagg acgagaccgc ccggctcgcc agcctgctcc agcacgccca
     5701 gcgcctcggc cgtatcggcg gcttcgagga gaatctgctg acggacgaga tcacctggaa
     5761 cgggcagctc ttcgccctgt acggacggcc gcccaccggc acccccgtat cgctgcgcga
     5821 actggccgcc cacgcgcacc cggacgacgg catcgccatc ggccgcttcc tgcgcgccgt
     5881 gctgcaccac cagcgctccg cctcggccgc cttccgtctc cagcgccccg acggcgtcac
     5941 ccggcacatc cgggtgatcg cggagcccgt acacgacgcc gaaggcagcc tcctcgccgt
     6001 gcgcggcgcc taccaggaca tctccgccca gcactggacc gaggtggcgc tcgccgccac
     6061 ccgcgaccag ctcgcccaca ccgagcagga atcggccgag cgcaaccgtc tcgcgctgca
     6121 actccagcag gccatcatgc cgccgacccg gggcccgatc gccgcgcccg gcctccagat
     6181 agccgtgcgc taccggccgg cggaaaccga gtccctggtg ggcggcgact ggtacgacgc
     6241 ggtcgtcctg ccgtcccggc gcgtgctgct ctgcgtcggc gacatcgcgg gccacggcat
     6301 cgaggcggcc accggcatgg tggtcctgcg caacgcgctg cgcggcctcg ccatcaccgg
     6361 agccggcccg gcgcagctgc tgtcctggct gaacatcgtg gcgcaccacc tgaccgacca
     6421 ggtcaccgcc acggccgtct gcggcctgta cgaccccggg acccgcaccc tgcgctgggc
     6481 cagagccggc catctgccgc cggtcctggt ccgcggccgt gaagcgaccc ggctgcccct
     6541 ggtcggcggc ctgctcctgg gagccgtcgc ccaagcgacc tacgaggagg ccgaactcca
     6601 gctggaagcg gacgacaccc tcctgatgta cacggacggc ctggtagaac gccgcgacac
     6661 cgccatccac gactccctgg cccaactgct cgccaccgca cagtcccccg cgcccacgct
     6721 ggaacaccgg ctcgatcaac tgctgacgca cagcaagtcg gacacggacg acgacacgtg
     6781 tctggtgggg attcaggtgg tgtgaggcgg tgggggcggg agagcccatg cccttgacca
     6841 ccagcgctgt tacgcatatt cagggccgga cagaacacac ctgtgaagca ggctgccagt
     6901 gctgggtgaa cgccggcgcg ttggcgtccg gaacgtattc caggcggacg ccgcgcttgc
     6961 ccagcagccg cttcagttcg gcctggctcc gagcaccgtt cctgaggtca ccacgtccat
     7021 gtagaacgcg agggaatacg gggtcatgtg gtcgctcgat acggtaaacc ggcctctcgg
     7081 aaacggtcca gcgggcaacg gtacaccgct gatcccccgc cttggctcga actcatccac
     7141 gcatccgccc cgaagcatgc caacctgaca gcaccccccg cgcgaggaag gtgccgacat
     7201 gaccaacacg tacctgcccg ggcagccgag tgaggcgcag cttcccgatt tcagtgctct
     7261 gccgctcggg gagctggcgt ctcgtacgga gcatccggtg ctgggcacgc tgctccccgg
     7321 cgtgtgcgag cgtctggagg atccgggcag cgcggtcgcg ttctacgatg acgcgcctcc
     7381 tgttgcgtga gtgaggcggt ccggcccgtt ccctttcggc agttcgtgct caaggtgcac
     7441 agcaggtgca acctcgcttg tacctactgt tacgtctacg agggccccga ccagagctgg
     7501 cgcgagcgtc ccgtccgcgt ggccgagcgc accatgcgcc gtaccgcgga gcggatcgcc
     7561 gagcacgtcg ccgcccacgg gctgcgttcg atacgtatcg acctgcacgg cggagaaccc
     7621 ctgctcgccg ggcccgccgc gctgatcgcc tacgcgcaga ccgtccgcga cgccctgcca
     7681 caccactgct ccgtagccgt ttcggtgcaa accaacggca cgctgctcac cgcgggcatc
     7741 ctgaagcagc tcagcgcggc cggcatcacc gtcggcctga gtctcgacgg cggcagcgcc
     7801 cgcctcaacc gccggcgcat cgaccgcgcc ggacgctcct cgtggccttc ggtacggcgc
     7861 gcggccgggc tgttggccga tgcccccgcc tcgtacgggg gcattctgtg caccatcgac
     7921 gtggacaccg accccgggga gatctaccgg tccttggtcg cgctcggccc gcccagcctg
     7981 gacttcctgc tgccgtacgg gaattggagc gagccgccgc ccgggatcgg cccgttcgcc
     8041 gggcccgggt gccgggcggc gcgccctgtc ccgtacggtc actggctggc tcacgtcttc
     8101 gacctgtggt gggatacgcc gtccggccac ccgcccgtgc aggtgcgcct gttcggagag
     8161 atcgtggcgc tgctgctcgg cgcggcgagc aggaccgaga cggtgggtct ctccccgctg
     8221 gccgttgtgg tggtcgacac tgatggttcc attcaacgcg tcgattccct caagaccgcg
     8281 tacgcgggcg cacccgacct ggaaatggac gtattccgga acgacttcga ggacgccctg
     8341 caccacccgg ataccgtggc cgctcagatg cgcggactgg tcacgctgtg cgacagctgt
     8401 cggagctgtc ccgtggtcgg tgtctgtggc ggcgggaggt acaccgaccg ttatgtgcac
     8461 ggcacgggct tcgaccatcc ttcggtgtac tgcgcggatc tggaatacct gattcgccat
     8521 atcggcgatc ggcttcggca ggccgtgtgc aaagagcgtg cccatgtgga atagagctca
     8581 gtgcctggct cccggtacgc tgcgcccatg ccctacggga tcactctctt ccgccggctt
     8641 ccgggccgta cgctctcgga aacgctcgac catcgggccg cggcttggga tggtgatgtg
     8701 gatttcgagc ggagccccat gaacctcacg ccggaccggc gcgccgcttg ggatgagatc
     8761 gtgcgccggg tgagcgcgga gatcgggccc gtatccgtcg aggaataccc gtacaacctg
     8821 accctggaac gcaatgggcc cgtcggccgc attcagctcg actacgacgg ggactcggcc
     8881 gaaatcgagt tcgcgtaccg tcatttcggc gaggcggcgc ggcagatcgt cgtggaggcg
     8941 taccgtctcg cggccatcgt ggaagacgtt accgggctcg taggcttcga ctgccagacg
     9001 gaacgcccta cggccgaggg tgacatcgat gcggccgccg ccctgctcgg cggcatttcc
     9061 cactgggccc ggaccgagat tccccgcatg ctggcggaag accggccggg gacggggccc
     9121 cgtaactgat cggatcggcc gacggcagcg ggcggccgag ccttgtactc cccgctgcgc
     9181 ccgccctcac atccgttccg gcgccgaaac cccgagcagc cgcagcccgt tgctcagcac
     9241 caccctgctg gcctccgtca gccacagccg ggcccgggtg cggtcgtccg gggcctcgcc
     9301 ggtgcgcggc aggacgcggc aggcgtcgta aaagcggtga tacgtggcgg ccagggcctc
     9361 caggtagtgc gccaccctgt gcggttcgcg cagcgtcgcg gcgcccgcca cgacctgcgg
     9421 aaactcggcc agcatgccca gcagaaccgt ctcccgcggg tgggtgagca ggcaaggatc
     9481 gaagtcctgc ggtgcgccct tgtcgattcc cgcttcccgc gccttgcgct gcacggcgca
     9541 cagccgggtg tgcgcgtact ggacgtagta gacggggttg tcgttcgact gccgggtgag
     9601 caggtcgatg tcgaggtcga tcaccgcgtc cacgctgacc cgcgcgagcg cgtaccgcgc
     9661 ggcgtccaca ccgaccgctt cgaccaggtc gtccagggtg accaccgtgc ccgcccgctt
     9721 gctcatccgg accggctccc cgtccctgac gaggttgacc agctgcccga tgaggatctc
     9781 caggtgggtg tccggatcgt caccgaagca ggccgccatg gcacgcatcc ggcccacata
     9841 gcccgcgtgg tccgcgccga gcatgatgac gacccgctcg aagccccggg agcgcttgtt
     9901 gaggtaatag gcgcagtccg cggtgaaata cgtccaggaa ccgtcgctct tcaccagcac
     9961 ccggtccttg tcgtcaccga agtcggtcgt gcgcagccag agcgcgcccg cctcctcgaa
    10021 gacgtggccg ccttcccgca gtcgtacgac cgcggcgtcc aggtcacccc ggtcgtgcag
    10081 gtccttctcg ttgaagaaca cgtcgaaacg ggtgccgaac gcggcgagcg acgccttgat
    10141 ctcgtcgaac atcagcgccg taccctctgc ccggaagacg gcgagggcag ccgcggagtc
    10201 ggacagctcc agcacaccgg gccgccgccg caccaccgcg gcggcgatct cctcgatgta
    10261 cgcgccgccg tagccgtccc gcggcaccgg cgagccctgc gccgcggcga gcagggagcg
    10321 cgcgaaccgg tcgatctgca cgcccgcgtc gttgaagtag tactcccgcg ccacgtccgc
    10381 ccccgcggcc tccagcagcc gggcgagcac gtcgcccacg accgcccacc gcgccccgcc
    10441 gatgtgcacc ggccccgtgg ggttcgccga gacgaactcc aggttgagcc gtacgccgcc
    10501 gagccggtcg gtacggccgt acgcgtcacg ggccagcaca atggcgcgcg ccagggcgcc
    10561 cagcaccccg ctctccagcg tgatgttcag gaatccgggg cccgccacct cagctttcgc
    10621 gatgccgtcg gccgcgctca ccagcggggc gattacctcg gcgacggtgc gggcgggcag
    10681 gccggcggcg ggggcgagcc gcagggcgac gttggtcgag tagtcgccgt ggtgacggtg
    10741 ccggggccgc tccacgcgga tctcctcggg cacggatacc tctgcggaga ggagcccgga
    10801 ccggatggcc gtgtgtacgc cgtcggagat gacggccgcg agatccgctg gagtcatggc
    10861 ggagacgcta gcggggcgga tggccccgga gacaccggat attcgggtgc ctcctacaga
    10921 cgccccccct acggatgctt cgtacagatt ccccgtacct atgcccttac agtccgaggt
    10981 ccagcgccag gcaggagaag tggttccacg atccttcggg gttgtacgtg ttctgtgcgc
    11041 ggttctccga tacggccttc tccgtgacca tgtcctcgta cgggatgcgc tcgggcagct
    11101 tgccgaactt cgcctgccgg gctgctgccg cgccatccgg cgtgttggtg ctgtgctgca
    11161 ttgtcgacct ccggtctttc agtcagggcg atcagggacg gtcagggtcg gtcggtccgg
    11221 gtcagccagt caggatcggt cggtcagaag tgatccacgt ccacgaccgc ctgggcgaag
    11281 gcggtggggg cttcctgcgg caggttgtgg ccgatgccgg tcagggtgcg gtgttcgtac
    11341 gcgccggtga accggtcgcg gtacgaggag ccgttgccgg gcgcggtgaa cgggtcgcgt
    11401 tcggggtcca gggtgatggt cggcacggtg atgaacggcc ggccggcgag ccgcttctcg
    11461 taacggtcgt aacggcgttc gccctcggcc aggcccaggc gccagcggta gttgtggatc
    11521 acgatgtcgg cgtagtcggg gttctcgaag gccatggcgg tacgcgcgaa cgtggcgtcg
    11581 tcgaagtccc acgtcggcga gacggtctcc cagaccaggc ggcacagttc gcggcgcttg
    11641 tccgcgtcct ccatggcgcg ccggccgcgc tcggtggaga agtagtactg gtaccaccag
    11701 gtgtgctcgg cccgcgcggg cagtggctcc tgctgcgcct cgacgttggt gatcaggtat
    11761 ccgctcaccg acaccagcgc cttgacgcgc tcgggccaca gggccgcgat gatgtcggcc
    11821 gtccgggtgc cccagtcgaa gccggccagt acggcccggt ggataccgag ggcgtccatc
    11881 agggcgacga tgtccagggc gaccgcggac tgctgggcgt tccggaacgt ggcggcggaa
    11941 cggaagcggg tcgagccgtg gccgcgcagg tacgggacga tcacgcggta gccgcgtgac
    12001 gccagcaagg gggcgacatc gacgaagctg tggatgtcgt aaggccagcc gtgcagacag
    12061 atgaccaccg gcccgtgcgc ggggcccgcc tccgcgtaac cgacgttcag cagccccgcg
    12121 gcgacgtgcc gcatccggtc gaaggtcgtg tgcgtaccgg gggcgatgtc ggggagggcg
    12181 gatgcgctcg tacggcccgg agcgctctta ctgcctgaag tactcgggcc tgaagcgctc
    12241 cggcccgagc ggggagccgc ggcaacgggt gcggcctgcg ggccggtcag cgatacggct
    12301 gccgcgccgg tgcccagcgc catggccttg ccgaaggtgc gcctgttgat catcggggcc
    12361 tccgtgtgct gttccgtctg cgtccgcgtg ccgtgccggt accaagtgcg gcatgactct
    12421 tgcaggcatc gcgtcaccgg tcaagacggt gacgaacgcg ggagcgttcc catggcgcga
    12481 ggcccgctcg ggttcgggtc cgctactggc caggcgttta cgggttccgc caattccgct
    12541 cccccacggg ctcgttcggc ccagcagatc gattccagcc acccgcgccc acccgccccg
    12601 cacgccggga gcaacaccta ccccttcctt tacaacccga ccacccgcac cccacctgac
    12661 gtgcgctcac gcacccacaa ctcccccggt ccccgaaccc gcgcaccaga cgcaggccgg
    12721 ccacacacca ccccaccagg acacaaacgc caggtcgccg cgccactcca cctgaccgaa
    12781 gttccatctg tacgggacga aggcgagctg cgtaccgtat cgatcaggca gaacgaacgt
    12841 tctttctgcc ggaaaggcac ctcatgatcg accgtcaccc gccgctgcac tccagcagca
    12901 ccacaacaac cacccccgat ccccccccgg ccccccccgc ccgcctcccc tccagcgacc
    12961 cgatgagcgg cgtcacccgg tccgaactcc agcggcaccc gtcgccggcc aagggctggc
    13021 tcaccgtgca gaccgtcgtg gagatccccc agcacaagga gtccggccgt cacagccacc
    13081 ccggagtcga agtcgggtac atcgtgcgcg gcgacgtgct gatggagttc gacgacggcc
    13141 ccgcccaacg gctgcgcacg ggcgacccgt tcttcatccc gtcgggcatg atccacaacg
    13201 cccggaacgt cggcacggtg acgacgatga tgctctccac ctatgtcatc gacgagacca
    13261 agccgctggt gacgacgtac tgacgacatg gcggcaacgt agcggcggcg ccccggcagc
    13321 tccctgaggt gacgggccga ccggcgtcgg tgggccgtcc gtacgctggt ggtcatgact
    13381 tcgagcgcca gtgggacgat ccatccgcgt gagcggctgc tgaacatcgc gggaaagctg
    13441 ttctacgcga acggaatcca caccgtggga gtcgaacaac tcgtacggga ggcgggtgtc
    13501 acccgggcca ccttctaccg tcatttcgcc ggcaaggagg gcctggtggt cgcctacctg
    13561 caggagcggg acgcccgggt caagcgggcg gtggaggcca tcctccgggc ccaccggggg
    13621 cgcgacgccc tgctggagat cgtcgccatg atcgccgaca ccgttctgcg gccggagttc
    13681 cgcggctgcg gtttcctcaa cgccgccgcc gagtaccccg atccgcggca tcacgtacgc
    13741 ctctgtgtgg ccgagcaccg cgactggttc cgcggcgtgc tgcgcgatgt cgcgcacgat
    13801 gccgggcacc ccgaccctga ccgggcggcg cgggcgctga tggtgctgcg cgacggagcg
    13861 atggcggccg gatacctcga cgacccgcac gatgtcgccc gcaccctgcg cgaggcggcc
    13921 gaaagcatcc tggacgcttg accggacccg gacccggctg cgaacccggg cccggcccca
    13981 tgccccggac cccagcccga cgccatcggc gcaccgtccg tgcaccgtcc gcgcccaacc
    14041 ccacccccac caccccaagg cggagacatg accacaaagt tcaccagatt cgcggccgtt
    14101 accggcggag tcctcgcgag cgggctcctg atgctcggcg ccgcgggctc gcccgccggc
    14161 gcggccgaac tccccggagt caccttctac accggagcga acgccaccgg cagcgccgtc
    14221 gaggccgacc tcggcaaggt cggcgtgtgc caggaactga ccactcccgt acggtccttc
    14281 cgcgccgtcg ccgaccggag cgtggaggtc tacttcaacg ccggctgccg cccgggcgct
    14341 cccggtacga acggcgacct ggtcttcgtg gtgggctcgc tgaactccgg cgaccttccc
    14401 taccccggtg tcagctaccg cgtacgcgcg aacgcgggct agccggcagc agtcgcgggc
    14461 gcgctcttct tccgcgcccg gtacgcagcg gccttgatct tgttgccgca cgattccatg
    14521 ccgcaccagt gccgccgcat gccccgcgag cggtcgatgt agacgcgggt gcactcgggg
    14581 ttgccgcact ccttgagcag cggtacgtcc gggccgctca gcagttccac cgcctgccgg
    14641 gccacggcgg acagcgcctc ctgcgaggtg gcgtcggtcc ggcgcccggt cctggtgagc
    14701 tgcggggccg cggcgggctt gcgggccgcc gcgttgagca cctccagggc ccggtcgccg
    14761 aagggttcgc cgaggcggcg ggcggtgatg agttcgtaga ccgcttcccg tacggccttc
    14821 gcgcgctcga cgtcggacgg ccggctgggc gccacggagt ccacgatccc ggactccacg
    14881 taccacgcgt ccagccggtc cggcgccgcg aacatctcga agcgcaggga gcgccgggcc
    14941 ctgagcgtcg cggcgaagtc gagggccgga tgtccgcaga cgaagacatg atcgaggttc
    15001 acggtcacca ttctggcggg tgaccgtggg cccggcaaag cccgtcagcg acacagtggg
    15061 cgccccttgg gtcgcgcttc gccgctctcg tccgcgtgcg cccggccgga gctcaggtgc
    15121 aggcgccggc cgttccagcg cccgcgcagc caccggtcgt ggctggccac gacgatcgtg
    15181 cccggtcccg ggccgagggc gtcctccagc tcgtcgcaca agcgcgggga caggtggttc
    15241 gtcggctcgt cgagcagcag gaggtgcggc gggcgcgcca ccagaagggc gagcgtgagc
    15301 ctgcggcgct ggccgaccga cagctgtccc accggtttgc cgaggtccgc ggcgtgcagc
    15361 agccccagtg agccgagcgg caccgcttcc gcccgctcgg cgcccagtac gtacgtatag
    15421 gtgtcgcgcg ccgtacggtc cgggcgctcg aacgtggtgt cctgtgccag cagccctacg
    15481 gacaggcccg gccgcctgcg tacctcgccc tcggcgcgga gccgcccggc cagcagcgac
    15541 agcagcgtcg attttccggc accgttgcca cccgtgacca ggagccggtc tccggagggg
    15601 acgtccagcc ggtcgaggta caaccgaccg ggtacgcgta cgttccgcag ctctacgaga
    15661 ggggcgtcaa ccagttccgc cggctccgcc gtcttccccg cctcctccgt ccccttcacc
    15721 tctacggcaa ccgccccgac atgcagccgc aacggccgcg gcggctcgcc cacctgcgtc
    15781 cgctccagtt cttcgagccg gcgggtggcg ttgcgtaccc gccgggagat ctgctgctgt
    15841 acccggcccg cccggtggcc gtaacccatc ttctcgttgt cccgccgccc gcggtccggg
    15901 gcgacgcggt gcgcggtcac cccggccgag cggcgcagct cctccagttc ctcctgttct
    15961 tcggcgtatc tgcgctccca gcgctcccgt tccgcgcgct tctcggcctg ataggcgctg
    16021 tagttgccgc cgaaacgcac gggaccgtcc acggccgggt cgagatcgat cagttccgta
    16081 cagacggcgt cgagaaacgc ccggtcgtgg ctcgccacca caacgacgcc gggcagctcg
    16141 cggagccggc cttccacgaa ggcggctgct tcgtcgtcga ggtggttggt cggctcgtcc
    16201 aggaggaggg ccgcggggcg gcgtacgagg agcgcggcca gggcgaggcg gccgcgctgt
    16261 ccgccggaca gggagccgag cgtccggtcg tgcgcgatgc cgccgaggcc gagcccgtcg
    16321 aggacgatcg cggcccggcg gtcggcgtcc caggcttcgc gttcctgggc ctgttcgagc
    16381 cgctgcccgt acgtctccag cagctcggcg tgggcggggc ggtcctcggg ggtgtcggcg
    16441 agcagccggg tgagccggtc gagttcggcc aggtcggtgc gggcttcccg gagggcgtcg
    16501 tccaggacgc gggcgatcgt cgcgtcaccg gcgaacggca tctcctggtg caggaagccc
    16561 aggtcgtccg ggcgggtgac ctggccggcg tcgggttcgt cgacgcccgc gagcaggcgc
    16621 agcagtgtcg acttgccgac accgttctcg ccgatcagcc cgacgcggtg gccgggtgcg
    16681 gcggtgaggg acacgccgtc caggatccgt cgggtatcca gtgtgcggac gaggtcgtgg
    16741 gcgagcagag ctggtcgggg cat
//
