LOCUS       reptomyces_RBGC_457222 17564 bp    DNA              BCT 09-SEP-2019
DEFINITION  RiPPTIDE predicted RiPP gene cluster.
ACCESSION   Streptomyces_RBGC_457222
VERSION     Streptomyces_RBGC_457222
KEYWORDS    RiPPs; RiPPTIDE.
SOURCE      GCF_002188355.1
  ORGANISM  GCF_002188355.1
            .
FEATURES             Location/Qualifiers
     CDS             complement(2..1065)
                     /protein_domains="PF01497"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790824"
                     /pseudo=False
                     /translation="MNRARRLAASASTGLALLLATACGTTDVDQPEAAAGADAAPASKS
                     CADDTTATSTGPVSLKDGVGRTVKLDKPAERIAVLEWQQVEDALTLCVTPTAVSDAKGY
                     STWVSAEKLPDGVTDIGTREEPDLDTLYAAKPDLIVVEAFDAEDETIAKLEKRGVPVMA
                     TRGADPKDPIGNMREVFSMIGEATGRTERADQVLKEFDEHLATAKQKVADADLPTSDFL
                     FFDGWLQGGNLTIRPYSDGALFTEIGKELGMKPAWDAKVDKDHGDGGVDPSYGLAQTDV
                     EGLAAVGDANLFYANDEGAGGYVEALGKNPIWKSIPAVKEGRAHAFPARVWGAGGPRSC
                     AQAIDAYVDVLDKK*"
     CDS             complement(1133..1995)
                     /protein_domains="PF00005"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790825"
                     /pseudo=False
                     /translation="MLTSPSRRADRPGTGPAAPATALHGHDLLLRYGGTPVVHGVSLTL
                     ERGRATALVGPNGSGKSTLLRALARLHRVESGRVALGAADGAPERDAALLSSRQFAREV
                     TLFSQSRPAPQGLSVREVVAFGRHPYRRGFGGTTPEDRAAVDHAMDVTGVREMAVRQVG
                     ELSGGEMQRVWLAACLAQDTGVVLLDEPTNHLDLRYQFETLDLIRELVDEHGIAVGVVL
                     HDLDHASRVADSLVLMRAGRVHAAGAPAEVLTAENIAEVYDIRVEVTADLRTGRLRIDP
                     IGRRSS*"
     CDS             complement(2164..2996)
                     /protein_domains="PF12833"
                     /protein_domains="PF02311"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790826"
                     /pseudo=False
                     /translation="MWRREAGTEVRRAVALPEQAPFVILSEFQVPRVPTEWSPHAHPRH
                     ELVWVRGGTLTSRVADRIFTVSEGHGLWMPAGTVHGGRATAGAEFHDAFFAPERTPFAF
                     REPVAITMTPLLESLLTHLARTDLEAAARARAEAVVFDVLQPSEHQFALQLPGDPRIDP
                     IAEALLDDPGDGRSLQEWARELGTSDRTVTRAFRQATGLSFARWRQLLRAHQALLLLSA
                     GHEVTTVSELLGYAQPSSFIAAFRRVMGTTPGAFFGGADDQPGHVRNPVSGVQNS*"
     CDS             3230..4641
                     /protein_domains="PF00083"
                     /protein_domains="TIGR00879"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790827"
                     /pseudo=False
                     /translation="MAQGFSREPGTHGPLEEVPRRAARKITLWAAAIALGGFLFGFDTG
                     VISGALLFIREDFTLSSLQQSSVVSVLLIGAVVGSMLSGKLADRIGRRRTLGLVGLVFL
                     GGTAVVTFADGFLMLLTGRIVLGLSVGAASATVPVYLSEISPPAIRGRLLTLNQLMITV
                     GILAAYLVNLAFSASEQWRAMFAVGAVPAALLVAATLWLLPESPQWLITHGRAEVAHRG
                     ITALIGKDAADEIVSRAQRRAAEERAAREKSAGRKKLLAPDVRPALIIGLTLAAVQQLG
                     GINTIIYYAPTIIEQTGLSSSNSILYSVCIGVINLVMTLVALRLVDRAGRRPMVLVSLA
                     LMAVSVFLLGLSFVVELGSGLTLLFMVVYIAAYAGGLGPVFWTLIGEIFPPSVRAEGSS
                     VSTAVNWVSNFAVSLTFLPLAAALGQGETFWVFAAICVLAFLFVSRYLPETKGRDADEI
                     DRALHQRFGSRQ*"
     CDS             4698..6124
                     /protein_domains="PF02781"
                     /protein_domains="PF00479"
                     /protein_domains="TIGR00871"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790828"
                     /pseudo=False
                     /translation="MREDTQYTPFDLERADALVLFGITGDLARKMLLPALYHLTARGDL
                     TVPVVGVASTGWDDAALRAHARQAVVEAVPDADPAVLDRLAGRLSMVSGDITEDATFTR
                     LRTAVDGFGFVAYYLAVPPALFTTVAAALARAGLNREARLVVEKPFGHDSASARELQDE
                     LSRCFDSAHLLRVDHFLGSEAVEGLMVGRFANTLLAPIWHRNYVDNVQITLAESFGVSD
                     RGSFYDAVGCVRDVVQNHMLEILTYLAMEPPGADDTSALGLEKWRVLRATRTMDPADTV
                     RGQYEGYREIEGVAPGSATETYVATRLFVDNWRWSGVPFYLRSGKALAVTATEVVVELR
                     KPPLELFGAKSGGTPPNIIRFRVDGDTGIRAELMLRKPDADGTPVTVPVGIDFERVLGR
                     QQLPYEAVLLGATVGNAEYFAFFPTIMESWRIVDPVLDPPEPPLPYAPGSWGPAEAARL
                     PGLRQWHQPSPRLFGDA*"
     CDS             complement(6148..8390)
                     /protein_domains="PF00069"
                     /protein_domains="PF13360"
                     /protein_domains="PF13360"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790829"
                     /pseudo=False
                     /translation="VSLRGSDPAEIGGYPLEARLGAGGMGTVFLARTSSGRPVAIKLIH
                     QQFAGDEEFRIRFRQEVAAARRVSGAFTAAVVDAAPEAEQPWMATTYIEGETLAEHIAA
                     AGPLDGVELRRLAIGLAEALRDIHRVGVVHRDLKPSNVVLSAEGPRVIDFGISRAADQQ
                     TLTMTGRVIGTPPFMSPEQLQAPRGVGPASDIFSLGTLLVYAATGSGPFDADSPYMTAY
                     QVVHEEPSLGAVPEALRRVVGSCLDKEPAGRPSADDLLVLLRDLPADLGGAGPTGTRAG
                     RTRDVITQHHDALPTPVPTAVAEAGTAETGTAETGTSVGRRLRDRWRPVLAAAVAVAAI
                     AGGVAALQSGDRAGGEGGDKAGNVAEPGASLPEGFTPWHETVAGGRADIPDELRCVARG
                     EALFCGGGGVVAARVDARDGSRAWTAKSPGVPVHGASLVGATDDTVVGYRFAAEDAPQD
                     PRSEVVALDAESGRELWSAPTGAQSTAVTGRNQDAVVSGSAVLMVDAANSRLEARDAHS
                     GEVTWATPFPSGTRCAPVLAGSRPLAMCAPDAELAESKVSDPVVHPLDRASGKLGRPVA
                     VKGPAVVVGDADGALVLLQEHWEGPAITGYDGIARVDPASHEVAYARLKDTYAGTPGMA
                     GGVVHVSGATGRITALDPVTGREKWARQTAVEGASGPTAGEGALYFSSPTGRVVALDSD
                     DGKILWSTDPQADGLTGEQGASPRVTLAGRAVVVAADNNTLFAFDARNPPKPG*"
     CDS             complement(8536..9260)
                     /protein_domains="PF11575"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790830"
                     /pseudo=False
                     /translation="VTGPRAVRLPDAARAPAGAVADALSEVARLGGFFVVRVGGPDQGW
                     QPLTRSYAAGFTDLAEAVARRHRTDEPRVGVSIAQLGHAARLWSPALATAVRHGIVLDL
                     DGLQRADDGPALRLPRAAGWYADARDDLAAPALHAQVTRQLRALAEGLRVKVAPRLLDG
                     NSASALVEAARALLAADPAAREALTALTGRLLATGHLRGTGATTGPALGFRRRSCCLYY
                     RAPNGTKCGDCGLAGTGVP*"
     CDS             complement(9258..9640)
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790831"
                     /pseudo=False
                     /translation="MPADIAPVPPGREPVPCRVVVCRDCCCGTPKITGVDHAAQTARLR
                     ALVPVRVSACLDVCEQANVIVVQPSAEGRAAGARPVWFGLVNDPDATEDIATWALAGGP
                     GVAPLPDILDLYIVTPPRRRTPS*"
     CDS             complement(9788..9984)
                     /SVM_predicted_precursor=True
                     /pseudo=False
                     /translation="MAPDMIGGTEPSDGCQLVPIFPAVSAKVAKAGGPGRSAVPDGRMA
                     RQTGDGGRGSRWKSGAVPPL"
     CDS             complement(9970..10325)
                     /protein_domains="PF13586"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790832"
                     /pseudo=False
                     /translation="MERIRVPQLGPGRPRTTPDSVSADKAYSNRRTRRYLRRRGIRHVI
                     PEKSDQAVNRVRRGRAGGRPPGFDKERYKKRNTVERAINKLKNYRAVSTRYDKRAHVYL
                     GTVTVAATIIWLRT*"
     CDS             11995..12593
                     /protein_domains="PF13305"
                     /protein_domains="PF00440"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790833"
                     /pseudo=False
                     /translation="MARTNAYHHGDLRAACLRAARELLEEDGGAGLSLRAVARRAGVSA
                     TAPYRHYADREALVSAVAAEGYRELAEHLAKAHPAPSTPDELAAVAVAYVRFALDHPAL
                     FRAMFAEPCDPTSEERVAATNAIHKYVRSVVRTTFPGADAEALSTTAWALVHGLAFLHL
                     DGKLDASTPEAVTTQVTAAVHALFDTAPALSPETRR*"
     CDS             12742..12905
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790834"
                     /pseudo=False
                     /translation="MAGPHADRGPVDGRRGVIALRSSGLFPHLATLSPETIGAMLESAA
                     LAPAPETAG*"
     CDS             13116..14251
                     /protein_domains="PF07995"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790835"
                     /pseudo=False
                     /translation="VNVRTRCSAVIGTLCLVASVALATASADEPDTPVQPDAVTLTDVA
                     KAQNPTAGAAGPDDTVWIAERAGTVRVLDGEGLSDPVLDISDQTTTDGERGLLGIAFDE
                     SLAHFYLSYTDLEGTSTVEEFAVENGAVQPDSRRTVLTQEQPYSNHNGGAITFGPDGYL
                     YIALGDGGSGGDPHGNGQNLDTLLGKILRIDPSGGDPYAIPADNPFVDDPEARDEIWAY
                     GLRNPWRFSFDKGTGDLLIGDVGQSDWEEIDWAPADSAGGENYGWSSMEGNHPFRGGTE
                     PANHVPPVHEYDRSGLGCSVTGGYVYRGEALPELQGQYVFSDYCDGTIRTLQIENGEVT
                     GEGDLGVSGGEVISFAESGDGELYVLNIGGEIQRIDPA*"
     CDS             complement(14321..16746)
                     /protein_domains="PF00933"
                     /protein_domains="PF01915"
                     /protein_domains="PF14310"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790836"
                     /pseudo=False
                     /translation="VTANIDNAGTGTPPAATDRPTGPWHDTTLTPEARADALLAAMTLQ
                     EKTAQLVGVWVGASDEGGEVAPFQHDMEEPVDLDALLPHGLGQLTRPFGTAPVDPAVGA
                     LSLARTQERITGANRFGIPALAHEECLAGFATWGATAYPVPLSWGATFHPELVGEMAAA
                     IGRDLRSVGVHQGLAPVLDVVRDARWGRVEETVGEDPYLVGTVATAYVRGLESAGVVAT
                     LKHFAGYSASRAGRNLAPVGMGARERADIILPPFEMAVRESGVRSVMHAYTDTDGIPSA
                     ADGPLLTGLLRDTWGFGGTVVADYFGIAFLKTLHGVAGSYGEAAAAALGAGVDVELPTV
                     KTFGRPLADALAEGLVPEALVDRAVRRVLVQKAQLGLLDAEWSPVPPALAEAEGADPQE
                     LRGTVRLDTEENRAVARRVAEEAVVLLRNDGTLPLAADPPAEAPARIALIGPHADTPTA
                     VLGCYSFPVHVGGRHPGTPLGIALPTLREALAAEFPHSEIVTAPGAELDGPATDGFGEA
                     VALARGADLVIVALGDRAGLFGRGTSGEGCDAEDLELPGVQQQLLDALLDTGTPVVVTL
                     LAGRPYALGRAADEAAAVVQAFFPGEEGTRAVASVLSGRTAPSGRLPVSVPRHPGSQPS
                     TYLAARLGHASEVSHVDPTPAFGFGHGLTYTTFAWSDLVVEREQAPTDGEFALSCTVRN
                     TGGREGTEVVQVYLHDPVASVVQPVRRLIGYVRLDLRPAEAARVRMTVPADLASFTGRD
                     GHRIVEPGALELRLGASSTDTRLAARVTLAGPVRTVDHTRRLHMGFETEVLTDAP*"
     CDS             complement(16744..17564)
                     /protein_domains="PF00528"
                     /SVM_predicted_precursor=False
                     /locus_tag="prodigal_5790837"
                     /pseudo=False
                     /translation="VSKTRPNHLAGFGSLLWLLVVGLPLYVMLVATFQSRPDYAANGPL
                     ALPERFTLDNYLDVLDSGFAQYFLNTLVVTVCVVGIVLLLVPPLAYTIVRSRGRATTTV
                     FRLFLLGLAIPSQAVIVPMFFVISEAGLYDSLIGVILPTAAFAMPVSALILSGVMRDIT
                     PDLYEAMTVDGASPRRVFFQLVLPLSRSGLSTIVVFSALQAWNGFLFPLVLTQSAETKV
                     ITLGLYEFQTEHGVDTPGLLAAVVLSMLPILLVYLFARRSLVQGLMGVGGK*"
ORIGIN
        1 tcacttcttg tcgaggacgt cgacgtacgc gtcgatcgcc tgcgcgcagg agcgggggcc
       61 gccggcgccc cagacccggg cggggaaagc gtgggcgcgg ccttccttga cggccgggat
      121 gctcttccag atcgggttct tgccgagcgc ctcgacgtag ccgccggcgc cctcgtcgtt
      181 ggcgtagaag aggttggcgt caccgacggc ggcgaggccc tcgacgtcgg tctgggcgag
      241 gccgtaggag gggtcgacgc cgccgtcgcc gtggtccttg tcgaccttgg cgtcccaggc
      301 gggcttcatg ccgagttcct tgcctatctc ggtgaagagg gcgccgtcgc tgtaggggcg
      361 gatggtgagg ttgccgccct ggagccagcc gtcgaagaag aggaagtcgc tggtgggcag
      421 gtcggcgtcg gccaccttct gcttcgccgt cgcgaggtgc tcgtcgaact ccttgagcac
      481 ctggtccgcg cgttcggtcc ggccggtggc ctcgccgatc atgctgaaga cctcgcgcat
      541 gttcccgatc gggtccttcg ggtcggcgcc ccgggtcgcc atcaccggga cgccgcgctt
      601 ctcgagcttg gcgatggtct cgtcctcggc gtcgaaggcc tccaccacga tgagatcggg
      661 cttggcggcg tagagggtgt cgaggtcggg ctcctcgcgg gtgccgatgt ccgtcacgcc
      721 gtcgggcagc ttctcggcgc tgacccaggt gctgtacccc ttggcgtcgg agacggcggt
      781 gggggtgacg cagagggtca gggcgtcctc gacctgctgc cattcgagga ccgcgatccg
      841 ctcggcgggc ttgtcgagct tcaccgtgcg gccgacgccg tccttgaggg agacgggccc
      901 ggtcgaggtg gccgtggtgt cgtcggcgca gctcttcgag gcgggcgcgg cgtcggcgcc
      961 cgccgcggcc tcgggctggt cgacgtcggt cgtgccgcag gccgttgcga gcaggagggc
     1021 gagcccggtg gaggctgacg ccgccaggcg acgggcacgg ttcatgggag ggtcctcttt
     1081 cttctgttct ctggcgaagg ggggtggcac gtccgggcgg cgggtgccgc ttcaggagga
     1141 gcgccgcccg atcggatcga tacggaggcg gccggtgcgg aggtcggcgg tgacctcgac
     1201 gcggatgtcg tagacctcgg cgatgttctc ggcggtgagg acctcggcgg gggcgccggc
     1261 ggcgtggacg cgtccggcgc gcatcaggac gaggctgtcc gcgacgcggg aggcgtggtc
     1321 gaggtcgtgc aggaccacgc cgaccgcgat gccgtgctcg tcgacgagtt cgcggatcag
     1381 gtcgagcgtc tcgaactggt agcgcaggtc caggtggttg gtgggctcgt ccagcaggac
     1441 gacgccggtg tcctgggcga ggcaggcggc cagccagacg cgctgcatct cgccgccgct
     1501 cagctccccg acctgccgga cggccatctc ccgtacgccg gtgacgtcca tggcgtggtc
     1561 gacggcggcg cggtcctccg gggtggtgcc gccgaagccc cgccggtagg ggtggcgtcc
     1621 gaaggcgacc acctcgcgga cggacagtcc ctggggcgcg ggccgcgact gggagaagag
     1681 cgtgacctcg cgggcgaact ggcgggagct gagcagggcc gcgtcccgct cgggggctcc
     1741 gtcggcggcg ccgagtgcca cccgtccgct ctccactcgg tggagccggg cgagcgcccg
     1801 cagcagggtg gacttgccgc tgccgttggg gccgaccagg gcggtggcgc ggccgcgttc
     1861 cagggtgagg gagacaccgt gcacgaccgg cgtgcctccg taccgcagca gcaggtcgtg
     1921 gccgtggagg gcggtggccg gtgcggcggg gccggtgccc gggcggtcgg cgcgccggga
     1981 ggggctggtg agcatggcgg ggtccggagg gtcggagggg cgggagagtg cggcaccctc
     2041 cgtccggccg tcaccggccg agccgcggac tcacccgcgc acgggcagca cccggcacgg
     2101 agagcaacaa ctaagggtca cctaactccg agaaggttat attccgcttg ccgtgtcgac
     2161 aatcaggagt tctggacacc cgatacggga ttccggacat gcccgggttg gtcgtcggcc
     2221 ccgccgaaga aggcgccggg cgtggtcccc atgacgcggc ggaaggcggc gatgaaggag
     2281 ctgggctggg cgtagccgag cagctcggag acggtcgtca cctcgtggcc cgcggagagg
     2341 agcagcagcg cctggtgggc gcggaggagc tggcgccacc gggcgaagga gagaccggtc
     2401 gcctggcgga aggcgcgcgt gacggtgcgg tcgctcgtcc ccagctcacg cgcccactcc
     2461 tgaagcgagc ggccgtcacc gggatcgtcg agcagggcct cggcgatcgg gtcgatgcgc
     2521 gggtcgccgg gcagttgcag cgcgaactgg tgctccgagg gctggagcac atcgaagacg
     2581 acggcctccg cccgcgccct ggccgctgcc tccaggtcgg tacgggccag gtgggtcagg
     2641 agcgattcga gcagcggcgt catggtgatc gccaccggtt cccggaacgc gaacggggtg
     2701 cgctccgggg cgaagaaggc gtcgtggaac tccgcacccg ccgtcgcccg gccgccgtgc
     2761 accgttccgg cgggcatcca gagcccgtgc ccctcggaga cggtgaagat ccggtcggcc
     2821 acccgggagg tcagcgtccc tccgcgtacc cagaccagtt cgtggcgcgg gtgggcgtgc
     2881 ggggaccact cggtggggac gcgggggacc tggaactcgg agaggatcac gaagggcgcc
     2941 tgctccggga gggccacggc ccggcgcacc tcggtgcccg cctcgcgccg ccacatcccg
     3001 gggctcgcct ctgcggggga cggaccggcc atgcgtccga gtctatcggc cccggtgccg
     3061 ggagcagcgc cctggcctgc gaggaccctc ggcgaggggc gggcggaggg cgtccggcca
     3121 cgacgccgtc ggcgttagcc cgatccggcc accccgcttt cccccgcgct gcttctgtgg
     3181 tcaggatgcg acccaagggt gtccgagccg actagcgagg gacgggacat ggcacagggc
     3241 ttctcccggg aacccggtac gcacggcccc cttgaggagg tcccgaggcg ggcggcccgg
     3301 aagatcaccc tgtgggccgc cgccatcgcg ctgggcgggt tcctcttcgg cttcgacacc
     3361 ggtgtcatct ccggcgccct gctcttcatc agggaggact tcaccctcag ctccctccag
     3421 cagagcagcg tcgtcagtgt gctgctgatc ggggcggtcg tcggctccat gctgagcggg
     3481 aaactggccg accggatcgg ccggcgccgg accctcggcc tggtcggtct ggtcttcctg
     3541 ggcgggacgg cggtcgtcac cttcgccgac ggcttcctca tgctgctgac cggccggatc
     3601 gtgctgggac tctcggtggg cgccgcctcg gcgacggtgc cggtctacct ctcggagatc
     3661 tcgcccccgg cgatccgcgg acggctgctc accctcaacc agctgatgat caccgtgggc
     3721 atcctcgccg cctacctcgt caacctcgcg ttctccgcca gtgagcagtg gcgggcgatg
     3781 ttcgcggtgg gcgcggtccc cgccgcgctg ctggtcgccg ccacgctctg gctgctgccg
     3841 gagtcgccac agtggctcat cacccacggg cgggccgagg tggcgcaccg gggcatcacc
     3901 gcgctgatcg ggaaggacgc ggccgacgag atcgtcagcc gcgcgcagcg gcgggcggcg
     3961 gaggagcgcg cggcccgcga gaagagcgcc ggccgcaaga agctgctggc gccggacgtc
     4021 cgcccggccc tgatcatcgg cttgaccctc gccgccgtcc agcagctggg cgggatcaac
     4081 acgatcatct actacgcccc caccatcatc gagcagaccg gcctcagctc gtccaactcg
     4141 atcctgtact cggtctgcat cggcgtgatc aacctggtga tgaccctggt ggcgctccgc
     4201 ctggtcgacc gggccgggcg gcgtcccatg gtgctggtct cgctcgccct gatggccgtc
     4261 tcggtcttcc tgctgggcct gtcgttcgtc gtggagctgg gctcggggct gacgctgctc
     4321 ttcatggtgg tgtacatcgc ggcctacgcc ggcggtctgg ggccggtgtt ctggaccctg
     4381 atcggcgaga tcttcccgcc ctccgtgcgc gccgagggat ccagcgtctc caccgccgtc
     4441 aactgggtgt cgaacttcgc ggtcagcctg acgtttctcc ccctggccgc cgctctcggc
     4501 cagggcgaga cgttctgggt cttcgccgcg atctgcgtcc tcgccttcct cttcgtctcc
     4561 aggtacctcc cggagaccaa gggccgcgac gccgacgaga tcgaccgggc cctccaccag
     4621 cgcttcgggt cgcggcagta gcggccgcgg cgtacgggca catcccgcgg gccggacagt
     4681 ggaaggaaga gccccgatgc gagaagacac ccagtacacc ccgttcgacc tggaacgggc
     4741 cgatgccctg gtgctgttcg ggatcaccgg tgacctggcg cgcaagatgc tgctgcccgc
     4801 cctttaccac ctgaccgcgc gaggcgacct caccgtgccg gtcgtcggcg tcgcctccac
     4861 cgggtgggac gacgcggcgc tgcgggcgca cgcccggcag gccgtcgtgg aggccgtccc
     4921 ggacgcggac cccgcggtcc tcgaccggct ggcgggccgg ctctccatgg tctccgggga
     4981 catcacggag gacgccacct tcaccaggct ccgcacggcg gtggacggat tcggcttcgt
     5041 cgcgtactac ctggccgttc cgcccgccct gttcaccacg gtggccgccg cgctggcgcg
     5101 ggccggactc aaccgcgagg cgcgcctcgt cgtcgagaag ccgttcgggc acgactcggc
     5161 ctcggcgcgg gagctccagg acgagctgag ccggtgcttc gacagcgcgc acctgctgcg
     5221 ggtggaccac ttcctcggct ccgaggcggt cgagggcctg atggtgggcc gcttcgccaa
     5281 cacgctgctc gcccccatct ggcaccgcaa ctacgtggac aacgtccaga tcaccctggc
     5341 cgagagtttc ggggtctccg accggggctc gttctacgac gcggtcggct gtgtacgcga
     5401 cgtggtgcag aaccacatgc tggagatcct cacctacctg gcgatggagc cgccgggcgc
     5461 cgacgacacc tccgcgctgg ggctggagaa gtggcgggtg ctgcgcgcca cccgcaccat
     5521 ggaccccgcc gacacggtac gcggccagta cgaggggtac cgggagatcg agggggtggc
     5581 ccccggctcc gccacggaga cgtacgtcgc cacccgcctc ttcgtcgaca actggcgctg
     5641 gtcgggcgtc cccttctacc tgcgcagcgg gaaggcgctc gccgtcaccg ccaccgaggt
     5701 cgtcgtcgaa ctgcgcaagc ccccgctgga gctcttcggc gcgaagagcg gcggcacgcc
     5761 ccccaacatc atccgcttcc gcgtcgacgg cgacaccggc atccgcgcgg agctgatgct
     5821 ccgcaagccg gacgccgacg gcacaccggt gacggtgccc gtcggcatcg acttcgagcg
     5881 ggtgctcggt cgccagcaac tgccctacga ggcggtcctg ctcggcgcca cggtgggcaa
     5941 cgccgagtac ttcgccttct tcccgaccat catggagtcc tggcggatcg tcgaccccgt
     6001 cctggacccg cccgagcccc cgctccccta cgctcccggg agctggggcc cggccgaggc
     6061 agcccgcctc cccggcctgc ggcagtggca ccagccctcc ccgcgcctct tcggcgacgc
     6121 gtgaggcgcg tgcctccggg ggcgcgtcag cccggcttcg gcgggttccg cgcgtcgaag
     6181 gcgaagaggg tgttgttgtc ggcggccacg acgaccgccc gcccggcgag ggtcacgcgg
     6241 gggctcgcgc cctgctcacc ggtgagcccg tcagcctgcg ggtccgtgga ccacaggatc
     6301 ttcccgtcgt ccgagtccag ggccacgacc cggccggtgg gcgagctgaa gtagagcgcc
     6361 ccttccccgg cggtgggccc ggaggcgccc tccaccgccg tctgccgcgc ccacttctcg
     6421 cggccggtca cggggtcgag cgcggtgatc cgcccggtcg ccccgctcac gtggacgacg
     6481 ccgccggcca tcccgggcgt ccccgcgtac gtgtccttga ggcgggcgta cgcgacctcg
     6541 tgggaggccg ggtccacgcg cgcgatcccg tcgtagccgg tgatggccgg gccctcccag
     6601 tgctcctgga ggaggacgag tgcgccgtcc gcgtcgccca ccacgacggc cgggcccttg
     6661 acggcgacgg gccggcccag cttcccggag gcccggtcga gcgggtgcac gacggggtcg
     6721 ctcaccttcg actcggcgag ttccgcgtcg ggggcgcaca tcgcgagggg gcggctcccg
     6781 gccaggacgg gggcgcagcg cgtccccgag gggaacggtg tcgcccaggt gacctcaccg
     6841 ctgtgcgcgt ccctggcctc caggcgggag ttggccgcgt cgaccatgag gacggcggag
     6901 ccggacacga cggcgtcctg gttccggccg gtgaccgccg tggactgggc gccggtcggt
     6961 gcggaccaca gctcgcggcc gctctcggcg tcgagggcga cgacctcgct ccgggggtcc
     7021 tggggggcgt cctcggcggc gaagcggtag ccgaccaccg tgtcgtcggt ggccccgacc
     7081 agggaggcgc cgtgtacggg gacgcccggg ctcttcgccg tccacgcgcg cgagccgtcg
     7141 cgggcgtcga cgcgggccgc gacgacgccg ccgcccccgc agaagagcgc ctcgccccgc
     7201 gcgacgcacc gcagttcgtc ggggatgtcc gcgcggccgc ccgccacggt ctcgtgccac
     7261 ggggtgaagc cctcgggcag ggaggcgccc ggctcggcca cgttcccggc cttgtcgccg
     7321 ccctctcccc cggcccggtc gccggactgg agcgcggcca cgccgccggc gatggccgcc
     7381 accgcgaccg ccgccgcgag gacgggccgc caccggtccc gcagccggcg gccgacggag
     7441 gtgccggtct cggccgtgcc ggtctcggcc gtgccggctt cggccacggc ggtgggcacc
     7501 ggggtgggca gcgcgtcgtg gtgctgggtg atcacgtcgc gggtacgccc cgcccgcgtc
     7561 ccggtgggtc cggctccgcc gaggtccgcc ggcaggtccc gcaggaggac gaggaggtcg
     7621 tcggcggagg ggcggcccgc cggttccttg tccaggcacg acccgacgac cctgcgcagc
     7681 gcctcgggca cggcccccag cgagggctcc tcgtgcacca cctggtacgc cgtcatgtac
     7741 gggctgtccg cgtcgaaggg cccgctgccg gtggccgcgt acaccagcag cgtccccagc
     7801 gagaagatgt cggaggcggg ccccaccccg cgcggcgcct gcaactgctc cggcgacatg
     7861 aaaggcggcg tcccgatgac ccggcccgtc atcgtcaggg tctgctggtc ggcggcgcgc
     7921 gagatgccga agtcgatgac gcgcgggccc tcggccgaga gcacgacgtt ggagggcttc
     7981 aggtcgcggt ggacgacacc gacgcggtgg atgtcgcgca gcgcctccgc cagcccgatg
     8041 gccagcctcc gcagctccac gccgtccagc ggtccggcgg cggcgatgtg ctcggcgagg
     8101 gtctccccct cgatgtacgt cgtcgccatc cacggctgct cggcctcggg ggcggcgtcg
     8161 accacggcgg cggtgaacgc gccgctgacc cgccgcgccg cggccacctc ctgccggaag
     8221 cggatgcgga actcctcgtc ccccgcgaac tgctggtgga tcagcttgat cgcgacgggc
     8281 cgccccgaac tcgtccgggc caggaagacc gtgcccattc cccccgcccc gagccgcgcc
     8341 tcgagcggat agccaccgat ctcggccggg tcacttccgc gcagcgacac tcttccggaa
     8401 ctcccctccc ccgggcatct ctgccatcac ggggccgcgt acctgtctcg ccccaaacta
     8461 gccggagcgc gatccccgcg ggcgacgcgg gtggggcggg gccggctccc ggccctctcg
     8521 ccgagcggtg gaggtcaggg cacgcccgtc cccgcaagcc cgcagtcgcc gcacttcgtg
     8581 ccgttcggcg cgcggtagta caggcagcag ctgcggcggc ggaacccgag ggcggggccg
     8641 gttgtcgcac cggtgcctct caggtgcccg gtggccagca ggcgcccggt gagggcggtg
     8701 agggcctcgc gcgcggcggg gtcggcggcc agcagggcgc gggccgcctc caccagggcc
     8761 gaggcggagt tcccgtccag caggcgcggg gcgaccttga cccgcaggcc ctcggccagc
     8821 gcccggagtt gccgcgtcac ctgcgcgtgc agggcgggtg cggcgaggtc gtcccgcgcg
     8881 tcggcgtacc agccggccgc cctcggcagc cgcagcgccg gtccgtcgtc ggcccgctgg
     8941 aggccgtcga ggtcgagcac gatcccgtgc cggacggcgg tggcgagggc gggggaccag
     9001 aggcgggcgg cgtgaccgag ctgggcgatg gagacgccga cgcgcggctc gtcggtgcgg
     9061 tggcggcgcg cgaccgcctc ggcgaggtcc gtgaagcccg ccgcgtagga acgggtgagc
     9121 ggctgccagc cctggtcggg gccgcccacg cgcaccacga agaagccgcc gaggcgggcc
     9181 acttcggaga gggcgtcggc cacggctccg gccggagcgc gggcggcgtc aggcaggcgt
     9241 acggcacgtg gtccggtcac gacggcgtac gccgtcgcgg gggcgtgacg atgtagaggt
     9301 cgaggatgtc cggcagcgga gcgacgcccg ggccgccggc gagggcccag gtggctatgt
     9361 cctcggtggc gtccgggtcg ttgaccagcc cgaaccagac cggccgggca ccggcggccc
     9421 gcccctcggc cgagggctgg accacgatga cgttggcctg ctcgcacacg tcgaggcagg
     9481 cggagacgcg gaccggcacc agggcgcgca ggcgtgcggt ctgggcggcg tggtcgaccc
     9541 cggtgatctt gggggtgccg cagcagcagt cccggcagac gacgacgcgg cagggcaccg
     9601 gctcgcggcc gggtgggacg ggggcgatgt cggcgggcat gcggcatcgt tcctctctcc
     9661 ggggagatcc gccccggtca accgtcgagg aggcgaccgc gtgagtctcc tggctctcgg
     9721 ctcgccgccc gttccgcgcc ttcccacccg ccgggggcag tggcctgtgc ggaacgtgct
     9781 cgccgatcac agtggcggga ccgcgccgga tttccaccgg cttcctcgtc cgccgtcgcc
     9841 tgtttgccgg gccatccttc catccggcac ggcagaccgg ccagggcccc cggccttcgc
     9901 gaccttggcg gaaacggccg ggaagatggg cacaagttgg cagccgtcac taggttctgt
     9961 cccgccgatc atgtccggag ccagatgatg gtcgctgcga cggtgacagt gcccaggtag
    10021 acgtgtgcgc gcttgtcgta ccgcgtggac acagctcggt agttcttgag tttgttgatc
    10081 gcccgttcca cggtgttgcg cttcttgtac cgctccttgt cgaagccggg tgggcgacct
    10141 cctgcccggc cccggcgtac gcggttcacg gcctggtcgc ttttctcggg gatgacgtgg
    10201 cggatgccgc gtcgccgcag gtagcggcgg gtccggcgat tgctgtacgc cttatcggca
    10261 ctcacgctgt ctggtgtggt tcgcgggcgg cctggcccga gttgaggcac ccggatgcgt
    10321 tccatgactg gctcgaactg cgtgcagtcc gcccgctggc ctgccgtcag taacagtgag
    10381 agcacgcggc aacgtccgtc ggcgctcagg tggatcttgg tggtgaagcc tccccgggag
    10441 cgaccgagcg cctcacctcc tgcaccacct ccgccaggcg ggcgcacaga ttcgcccacg
    10501 gtcttccgcg ctggtgtgcc atcgcggccg ccctttttga tgcggcgggc ggcggagctt
    10561 tccgcgcgcc ggccgcatgc tggtgggcac ggatcgaggt ggagtcaacc gagacgtccc
    10621 agtcgatccc accggcggca tcggcctggg cctgcacctg ttggagcagc cgttcccagg
    10681 ttccgtcggc tgaccagcgc cggtggcgct cgtagacggt ttttccacgg cccgtagcgt
    10741 tcaggcagct cacgccaccg caccccggtt cgcacccggt gcaggatgcc gttgatcacc
    10801 tggcggtgat cgcgccaccg cccgcagcgg cggttgttgc ccgtgggcag gagcggctcc
    10861 agacgtcgcc actccgcctc tgtcagatcc cctcgccccg tcatacaaga gccaacgaac
    10921 cagcgggtga catgggtgcg gtcagcatct gcgatgccac cacgccgact ccgggtcttc
    10981 cgtcggttcg tgatgcgttc gcccgaggag caccgcgtcc aggcgctcga cctgcacccg
    11041 aagttcgccg gcggcccttg gcggaagcat gaacagagcg tcttgcagct tgtcgcgggc
    11101 ccaacccttg ccgcagcaga ggcaggtgaa ttccgcctcc cattgtctcc accggcgtct
    11161 cgtgccgtgg acgcgcacgg accacacgct cagcgccacc gccacgatgc ccggagacaa
    11221 tcgctcccgt tcgagcacac ggacagccgc attcgccgct cccgacagac ctgggacatc
    11281 gcgataccgc acccagggcc taccccagcc gcgttcccgc ggccgaagtg aagctggtgt
    11341 tctacgaggc acggcccctt cggatgcaag tcatgggcgg catcctccca caacccatga
    11401 tcggcgggac aggtcctaat tgacggccct cagcgccgcc agcgccagag tctccgtatc
    11461 gtcaccccgg cagctggtca accggcgccc aactggccgc ccgccaccag cggatgccct
    11521 cccccagctc acagggacgc cacgcccgcc accgctctga gccacaacgt ccgcgttctc
    11581 gcggcacccg gtgcccgtcg cgacgaaatc ctcaccccgg ccgccctcga cttcgtgggc
    11641 cggctgaccg cggccttcgc cgaccgctgg caggcactgc tccgggagtg gcgccggcag
    11701 gcccggcggc tcgccgacgg ggtccccctg gactcccccg tggtcacctc ggcggtccgc
    11761 gccgacccgg cttggcgggt cgccggcccc gctccgggcc tggagaaccg gcgcgtggag
    11821 atcaccggcc cgcctgaccg ccgtaccgcc gtgcaagccc tcaagcccct caagacgacc
    11881 gccccgtgcc gcccggccgc gcgcaggtcg tccgtcgcaa ccgaccgact acgatgtaca
    11941 catcgttcac atcacgaagg gaatgtgaac tctgcacata taaggagcga cccatggcca
    12001 ggaccaacgc ctaccaccac ggcgacctgc gcgccgcctg cctgcgggcc gcgcgcgaac
    12061 tcctggaaga ggacggcggc gccggcctct ccctgcgcgc ggtcgcccgg cgcgcggggg
    12121 tgtcggcgac ggcgccctac cgccactacg cggaccgcga ggcgctggtc tccgccgtcg
    12181 cggccgaggg ctaccgcgaa ctcgccgagc acctggccaa ggcccacccc gctccctcga
    12241 cccccgacga actggccgcg gtcgccgtcg catacgtgcg gttcgcgctg gaccacccgg
    12301 ccctgttccg cgcgatgttc gccgagccct gcgacccgac cagcgaggaa cgggtcgccg
    12361 cgaccaacgc catccacaag tacgtccgct ccgtcgtccg caccaccttc ccgggggccg
    12421 acgcggaggc cctgtccacc acggcctggg cgctcgtcca cggcctcgcc ttcctccacc
    12481 tcgacggcaa actcgacgcc tccacccccg aggccgtcac cacccaggtg acggcggccg
    12541 tccacgccct gttcgacacc gccccggcac tcagccccga gacccggcgg tagccgcggg
    12601 cgggcgagcg ccgggcgagc gccccccggc cgcccggccg acccgcgccc ccatccggta
    12661 accaatgcca ttggtcgatg acatccgttg atgacaacgg cgccccacgg cagaactccc
    12721 accggaagga caccccgcac atggccggcc cgcacgcgga caggggcccc gtcgacggcc
    12781 gccggggcgt catcgccctg cgctccagcg gcctcttccc ccacctggcc accctgagcc
    12841 ccgagacgat cggcgccatg ctggaatccg cggccctggc accggccccg gagaccgccg
    12901 ggtagctccg gcccggcccc tggcgcgccc cgtggggcga cagttgacgg taccgatggt
    12961 ctaggccaaa ccccctccgt ccccctatcc tcaaccgtgg ccagtgaccc accgaccccc
    13021 acccggttgc gtactggctc gggccccacg cacgcagctc ccacccgagc agccaggtga
    13081 actcccccca tgtcgccgcc tccaggaggc cacggtgaac gttcgcacca gatgctccgc
    13141 cgtcatcggc accctctgcc tcgtcgcgtc cgtggccttg gccacggcat cggccgacga
    13201 gcccgacaca ccggtccagc cggacgcggt caccctcacg gatgtggcca aggcacagaa
    13261 tccgaccgcc ggcgccgccg gtccggacga caccgtgtgg atcgcggaac gcgcgggcac
    13321 cgtacgggtc ctggacggtg aagggctgag cgacccggtg ctcgacatct ccgaccagac
    13381 cacgacggac ggcgaacgcg gcctgctggg catcgcgttc gacgagagcc tcgcgcactt
    13441 ctacctctcg tacaccgacc tcgaaggcac cagcaccgtc gaggagttcg ccgtggagaa
    13501 cggcgccgtc cagcccgaca gccggcgcac cgtcctcacc caggaacagc cgtactccaa
    13561 ccacaacggc ggggccatca ccttcggccc cgacggctac ctctacatcg cgctgggcga
    13621 cggcggttcg ggcggtgacc cgcacggcaa cggacagaac ctggacaccc tgctcggcaa
    13681 gatcctgcgg atcgacccga gcggcggcga cccgtacgcg atcccggccg acaacccctt
    13741 cgtggacgat ccggaggccc gggacgagat ctgggcgtac ggactccgca acccctggcg
    13801 gttctccttc gacaagggca cgggcgacct gctgatcggc gatgtcgggc agagcgactg
    13861 ggaggagatc gactgggccc cggccgacag cgcgggcggc gagaactacg gctggtcctc
    13921 gatggagggc aaccacccct tccggggcgg caccgagccc gccaaccacg tcccgccggt
    13981 ccacgagtac gaccgcagcg gcctcggctg ctcggtgacc ggtggctacg tctaccgtgg
    14041 cgaggcgctg ccggaactcc aggggcagta cgtgttcagc gactactgcg acggaacgat
    14101 ccgcaccctg cagatcgaga acggcgaggt gaccggcgag ggcgacctcg gcgtcagcgg
    14161 cggcgaggtc atctcgttcg ccgagtccgg cgacggtgag ctgtacgtcc tcaacatcgg
    14221 cggcgagatc cagcgcatcg accccgcgta ggaccgagcg gcccggcgac tgcccggcgg
    14281 ggaccggagg gaagagctct cccgccggtc cccgccgggc tacggcgcgt ccgtcaggac
    14341 ctccgtctcg aagcccatgt gcagccgccg ggtgtggtcg accgtgcgca ccggcccggc
    14401 cagcgtgacc cgggccgcga ggcgcgtgtc ggtgctcgac gcgccgagcc gcagttcgag
    14461 agcgcccggc tcgacgatcc ggtggccgtc gcggccggtg aaggaggcga gatccgccgg
    14521 gaccgtcatc cgcaccctgg ccgcctccgc cggccggagg tcgagacgta cgtacccgat
    14581 gaggcgccgc accggctgga ccacggaggc gaccgggtcg tgcagataga cctggaccac
    14641 ctccgtcccc tcccgcccgc cggtgttgcg gaccgtgcag gagagggcga actcgccgtc
    14701 ggtgggcgcc tgttctcgct ccacgacgag gtcgctccac gcgaaggtgg tgtacgtcag
    14761 gccgtggccg aagccgaagg ccggggtcgg gtcgacgtgg gacacctcgc tggcgtggcc
    14821 cagccgtgcc gccagatagg tggagggctg ggagccgggg tggcgcggca cgctgacggg
    14881 cagccggccg gagggtgcgg tgcggccgct gagcaccgag gcgacggccc gcgtcccttc
    14941 ctcgccgggg aagaacgcct gcaccacggc ggcggcctcg tccgccgcgc gcccgagggc
    15001 ataggggcga ccggcgagca gggtgacgac gacgggggtg cccgtgtcga gcagggcgtc
    15061 gagcaactgc tgctggacac cggggagttc caggtcctcc gcgtcgcagc cctccccgct
    15121 cgtgccgcgc ccgaagaggc cggcccggtc gccgagtgcg acgatcacga ggtcggcgcc
    15181 tcgggccagt gcgacggcct cgccgaaccc gtcggtggcg gggccgtcga gctccgcgcc
    15241 cggggcggtg acgatctcgc tgtgcgggaa ctcggccgcc agcgcctcgc gcagggtggg
    15301 aagggcgatg ccgagcgggg tgccggggtg ccggcctccc acgtggacgg ggaaggagta
    15361 gcagccgagg acggctgtgg gggtgtcggc gtggggcccg atgagggcga tgcgggcggg
    15421 ggcttcggcg ggcgggtccg ccgccagggg cagggtgccg tcgttgcgca ggaggacgac
    15481 ggcctcttcg gcgacgcggc gggcgaccgc gcggttctcc tcggtgtcga gacggacggt
    15541 gccgcgcagc tcctgcggat cggcgccctc cgcttccgcc agcgccgggg gcaccgggct
    15601 ccactccgcg tccagcagcc cgagctgcgc cttctggacc agtacgcggc gtaccgcacg
    15661 gtccaccagg gcctcgggga cgaggccctc ggcgagcgcg tcggccagcg gacggccgaa
    15721 ggtcttcacg gtcggcagtt ccacgtccac gcccgcgccg agtgcggcgg cggccgcttc
    15781 cccgtagctc ccggccacgc cgtgcagcgt cttcaggaag gcgatgccga agtagtccgc
    15841 caccacggtc cctccgaagc cccaggtgtc gcggagcagg ccggtcagga gcgggccgtc
    15901 ggcggcggag gggatgccgt cggtgtcggt gtaggcgtgc atgacggacc gtacgccgct
    15961 ctcccggacg gccatctcga acgggggcag gatgatgtcg gcccgctccc gcgcgcccat
    16021 gccgacgggg gcgaggttgc ggcccgcgcg ggaggcggag tacccggcga agtgcttgag
    16081 cgtggcgacg accccggccg actccagtcc ccgcacgtag gcggtggcga ccgttcccac
    16141 caggtacggg tcctcgccga ccgtctcctc gacgcggccc caccgggcgt cgcgtacgac
    16201 gtcgaggacg ggggcgagcc cctggtgcac gccgacggag cgcaggtccc ggccgatcgc
    16261 ggcggccatc tccccgacca gctccgggtg gaaggtggcg ccccaggaga gcggcaccgg
    16321 gtaggcggtg gcgccccagg tggcgaagcc cgcgaggcat tcctcgtggg cgagggccgg
    16381 gatgccgaac cggttggcgc cggtgatccg ctcctgggtg cgcgccagcg agagggcgcc
    16441 cacggccggg tcgaccgggg ccgtaccgaa cgggcgggtc agctggccga ggccgtgcgg
    16501 aagcagcgcg tcgaggtcga cgggctcctc catgtcgtgc tggaacgggg cgacttcgcc
    16561 tccctcgtcg gaggcgccca cccagacgcc gacgagctgg gcggtcttct cctggagggt
    16621 catggcggcg agcagggcgt cggccctggc ctcgggggtg agggtggtgt cgtgccaggg
    16681 cccggtcggg cggtccgtgg ccgccggcgg tgtcccggtt ccggcgttgt cgatgttggc
    16741 ggtcactttc ctcctacccc catcagcccc tgcaccaggg accggcgagc gaacaggtag
    16801 acgagcagga tggggagcat ggacaggacg acggcggcga gcaggccggg ggtgtcgacc
    16861 ccgtgttcgg tctggaactc gtagagcccc agggtgatca ccttggtctc ggccgactgc
    16921 gtcaggacga gggggaacag gaagccgttc cacgcctgga gggcggagaa gacgacgatg
    16981 gtcgagaggc cgctccggga cagcggcagc accagctgga agaagacccg gcgcggcgag
    17041 gctccgtcga ccgtcatcgc ctcgtacagg tccggggtga tgtcccgcat cacccccgac
    17101 aggatcaggg cgctgaccgg catggcgaag gcggcggtcg gcaggatgac gccgatgagg
    17161 ctgtcgtaga gaccggcctc gctgatgacg aagaacatcg ggacgatgac ggcctgcgag
    17221 gggatcgcca gccccaggag gaacagccgg aagaccgtgg tggtggcgcg gccccggctc
    17281 ctgacgatgg tgtacgccag cggcgggacg agcaggagga cgatgcccac cacgcagacg
    17341 gtgacgacga gggtgttgag gaagtactgc gcgaaaccgc tgtcgaggac gtcgaggtag
    17401 ttgtcgagcg tgaagcgctc ggggagggcc agcgggccgt tggccgcgta gtcggggcgc
    17461 gactggaacg tggcgacgag catcacgtac agcggcaggc ccacgaccag cagccagagc
    17521 agcgaaccga aaccggcgag gtggttcgga cgggtcttgc tcac
//
