RiPP-TIDE results

Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_groups_2167 335.83 +- 270.37 4 0 3 0 0.11 +- 0.20 4 6

PF07969 (2/4) Amidohydrolase family
PF07859 (2/4) alpha/beta hydrolase fold
PF07729 (2/4) FCD domain
PF02126 (2/4) Phosphotriesterase family
PF00561 (2/4) alpha/beta hydrolase fold
PF00392 (2/4) Bacterial regulatory proteins, gntR family
precursor_groups_68013 42.47 +- 9.53 2 0 1 0 0.07 +- 0.05 2 9

TIGR00641 (2/2) methylmalonyl-CoA mutase N-terminal domain
PF14435 (2/2) SUKH-4 immunity protein
PF03308 (2/2) Methylmalonyl Co-A mutase-associated GTPase MeaB
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02310 (2/2) B12 binding domain
PF01642 (2/2) Methylmalonyl-CoA mutase
PF01321 (2/2) Creatinase/Prolidase N-terminal domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00557 (2/2) Metallopeptidase family M24
precursor_groups_40931 893.37 +- 424.28 2 0 2 0 0.01 +- 0.02 2 24

TIGR01733 (2/2) amino acid adenylation domain
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12802 (2/2) MarR family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01613 (2/2) Flavin reductase like domain
PF01474 (2/2) Class-II DAHP synthetase family
PF00975 (2/2) Thioesterase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_343 103.13 +- 13.39 3 0 0 2 0.12 +- 0.14 3 4

PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
PF02223 (2/3) Thymidylate kinase
PF00293 (2/3) NUDIX domain
precursor_groups_2166 106.97 +- 108.30 3 0 0 0 0.05 +- 0.11 3 6

PF17853 (2/3) GGDEF-like domain
PF14333 (2/3) Domain of unknown function (DUF4389)
PF13556 (2/3) PucR C-terminal helix-turn-helix domain
PF08448 (2/3) PAS fold
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF03492 (2/3) SAM dependent carboxyl methyltransferase
precursor_groups_12041 305.66 +- 186.24 7 0 6 0 0.07 +- 0.21 7 8

TIGR01181 (7/7) dTDP-glucose 4,6-dehydratase
PF17755 (7/7) UvrA DNA-binding domain
PF16363 (7/7) GDP-mannose 4,6 dehydratase
PF13460 (7/7) NAD(P)H-binding
PF05368 (7/7) NmrA-like family
PF03992 (7/7) Antibiotic biosynthesis monooxygenase
PF03559 (7/7) NDP-hexose 2,3-dehydratase
PF00005 (7/7) ABC transporter
precursor_groups_75537 54.17 +- 0.00 2 0 0 0 0.11 +- 0.21 2 6

TIGR01806 (2/2) putative chorismate mutase
PF13808 (2/2) DDE_Tnp_1-associated
PF07730 (2/2) Histidine kinase
PF01817 (2/2) Chorismate mutase type II
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_75535 1498.58 +- 93.92 2 0 2 0 0.01 +- 0.00 2 16

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03795 (2/2) YCII-related domain
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01738 (2/2) Dienelactone hydrolase family
PF00890 (2/2) FAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_74008 412.80 +- 103.20 2 0 2 2 0.01 +- 0.00 2 2

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00069 (2/2) Protein kinase domain
precursor_groups_70010 49.83 +- 15.17 2 0 0 0 0.04 +- 0.05 2 8

PF13481 (2/2) AAA domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF07508 (2/2) Recombinase
PF05713 (2/2) Bacterial mobilisation protein (MobC)
PF03432 (2/2) Relaxase/Mobilisation nuclease domain
PF00772 (2/2) DnaB-like helicase N terminal domain
PF00239 (2/2) Resolvase, N terminal domain
precursor_groups_18375 96.51 +- 36.71 4 0 0 0 0.15 +- 0.14 4 15

TIGR01392 (4/4) homoserine O-acetyltransferase
TIGR01326 (4/4) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF18029 (4/4) Glyoxalase-like domain
PF08007 (4/4) Cupin superfamily protein
PF06999 (4/4) Sucrase/ferredoxin-like
PF03404 (4/4) Mo-co oxidoreductase dimerisation domain
PF01184 (4/4) GPR1/FUN34/yaaH family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00561 (4/4) alpha/beta hydrolase fold
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
TIGR01409 (3/4) Tat (twin-arginine translocation) pathway signal sequence
TIGR02980 (2/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04539 (2/4) Sigma-70 region 3
precursor_groups_25857 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_groups_61625 148.71 +- 51.96 2 0 0 0 0.05 +- 0.05 2 6

PF14279 (2/2) HNH endonuclease
PF13560 (2/2) Helix-turn-helix domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF07508 (2/2) Recombinase
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF00239 (2/2) Resolvase, N terminal domain
precursor_groups_38466 1034.67 +- 3.77 3 0 0 0 0.01 +- 0.00 3 5

PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07690 (3/3) Major Facilitator Superfamily
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_78265 112.97 +- 0.00 2 0 2 0 0.19 +- 0.32 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16864 (2/2) Dimerisation domain
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_56123 69.55 +- 8.45 2 0 0 0 0.04 +- 0.05 2 3

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF00719 (2/2) Inorganic pyrophosphatase
PF00005 (2/2) ABC transporter
precursor_groups_52139 272.88 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR00212 (2/2) hydroxymethylbilane synthase
PF05977 (2/2) Transmembrane secretion effector
PF01379 (2/2) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF03900 (1/2) Porphobilinogen deaminase, C-terminal domain
precursor_groups_12911 39.50 +- 3.50 2 0 2 0 0.24 +- 0.16 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01443 (2/2) intein C-terminal splicing region
PF07591 (2/2) Pretoxin HINT domain
PF01804 (2/2) Penicillin amidase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
PF00501 (1/2) AMP-binding enzyme
precursor_groups_25690 172.67 +- 61.75 3 0 3 0 0.01 +- 0.00 3 3

PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/3) Phosphopantetheine attachment site
precursor_groups_58413 64.48 +- 6.70 2 0 0 0 0.06 +- 0.04 2 3

PF13545 (2/2) Crp-like helix-turn-helix domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_53332 174.34 +- 16.77 2 0 0 0 0.05 +- 0.03 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
precursor_groups_52131 106.50 +- 54.15 2 0 2 0 0.07 +- 0.21 2 10

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF13469 (2/2) Sulfotransferase family
PF12848 (2/2) ABC transporter
PF07883 (2/2) Cupin domain
PF07730 (2/2) Histidine kinase
PF04672 (2/2) S-adenosyl methyltransferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_24984 42.19 +- 25.31 4 0 0 0 0.07 +- 0.04 4 3

PF02386 (4/4) Cation transport protein
PF02254 (4/4) TrkA-N domain
PF02080 (4/4) TrkA-C domain
precursor_groups_59832 20.21 +- 2.07 2 0 0 0 0.15 +- 0.11 2 8

PF18050 (2/2) Cyclophilin-like family
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13359 (2/2) DDE superfamily endonuclease
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_31630 41.63 +- 6.54 4 0 4 0 0.07 +- 0.09 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF00905 (4/4) Penicillin binding protein transpeptidase domain
PF00266 (4/4) Aminotransferase class-V
PF00171 (4/4) Aldehyde dehydrogenase family
PF13472 (2/4) GDSL-like Lipase/Acylhydrolase family
precursor_groups_75436 171.39 +- 0.64 2 0 2 0 0.09 +- 0.25 2 21

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF08659 (2/2) KR domain
PF05199 (2/2) GMC oxidoreductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00732 (2/2) GMC oxidoreductase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_12857 518.00 +- 181.02 3 0 3 0 0.01 +- 0.00 3 3

PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01613 (3/3) Flavin reductase like domain
precursor_groups_17818 129.68 +- 33.50 4 0 0 0 0.12 +- 0.16 4 7

TIGR00996 (4/4) virulence factor Mce family protein
PF13406 (4/4) Transglycosylase SLT domain
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter
PF13577 (3/4) SnoaL-like domain
precursor_groups_60000 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_2368 283.71 +- 432.09 4 0 4 4 0.14 +- 0.23 4 10

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (4/4) Histidine kinase
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR01207 (3/4) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/4) dTDP-glucose 4,6-dehydratase
PF16363 (3/4) GDP-mannose 4,6 dehydratase
PF00483 (3/4) Nucleotidyl transferase
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
precursor_groups_1805 33.92 +- 2.07 4 0 0 0 0.18 +- 0.09 4 7

PF13377 (4/4) Periplasmic binding protein-like domain
PF12831 (4/4) FAD dependent oxidoreductase
PF07859 (4/4) alpha/beta hydrolase fold
PF06808 (4/4) Tripartite ATP-independent periplasmic transporter, DctM component
PF05378 (4/4) Hydantoinase/oxoprolinase N-terminal region
PF01968 (4/4) Hydantoinase/oxoprolinase
PF00356 (4/4) Bacterial regulatory proteins, lacI family
precursor_groups_19371 102.99 +- 16.27 4 0 0 0 0.16 +- 0.25 4 9

TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF13229 (3/4) Right handed beta helix region
PF03476 (3/4) MOSC N-terminal beta barrel domain
PF03473 (3/4) MOSC domain
precursor_groups_18719 303.08 +- 251.76 3 0 2 0 0.09 +- 0.20 3 4

PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF14031 (2/3) Putative serine dehydratase domain
PF01168 (2/3) Alanine racemase, N-terminal domain
precursor_groups_44605 280.61 +- 235.39 2 0 0 0 0.11 +- 0.30 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
PF00067 (2/2) Cytochrome P450
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
precursor_groups_19376 95.66 +- 39.40 5 0 5 5 0.14 +- 0.10 5 12

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (5/5) ABC-2 type transporter
PF00881 (5/5) Nitroreductase family
PF00005 (5/5) ABC transporter
TIGR03605 (3/5) SagB-type dehydrogenase domain
PF03704 (3/5) Bacterial transcriptional activator domain
PF00931 (3/5) NB-ARC domain
PF00486 (3/5) Transcriptional regulatory protein, C terminal
precursor_groups_44607 189.10 +- 128.56 3 0 0 0 0.09 +- 0.22 3 8

PF16884 (3/3) N-terminal domain of oxidoreductase
PF12146 (3/3) Serine aminopeptidase, S33
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/3) Major Facilitator Superfamily
precursor_groups_61925 68.00 +- 18.00 2 0 0 0 0.06 +- 0.04 2 6

PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01206 (2/2) Sulfurtransferase TusA
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00581 (2/2) Rhodanese-like domain
PF00266 (2/2) Aminotransferase class-V
precursor_groups_74313 93.75 +- 3.75 2 0 0 0 0.03 +- 0.03 2 4

TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
PF00106 (2/2) short chain dehydrogenase
precursor_groups_6399 65.80 +- 23.63 11 0 2 0 0.14 +- 0.16 11 9

PF16896 (11/11) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (11/11) Major Facilitator Superfamily
PF03807 (11/11) NADP oxidoreductase coenzyme F420-dependent
PF02733 (11/11) Dak1 domain
PF01261 (11/11) Xylose isomerase-like TIM barrel
PF00121 (11/11) Triosephosphate isomerase
TIGR02133 (10/11) ribose 5-phosphate isomerase
PF02734 (10/11) DAK2 domain
PF02502 (10/11) Ribose/Galactose Isomerase
precursor_groups_3146 8.40 +- 0.17 2 0 0 0 0.24 +- 0.29 2 3

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
PF02104 (1/2) SURF1 family
precursor_groups_1801 678.00 +- 483.00 2 0 1 0 0.01 +- 0.00 2 10

TIGR00055 (1/2) di-trans,poly-cis-decaprenylcistransferase
PF10633 (1/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (1/2) Alpha mannosidase middle domain
PF05977 (1/2) Transmembrane secretion effector
PF01255 (1/2) Putative undecaprenyl diphosphate synthase
PF01074 (1/2) Glycosyl hydrolases family 38 N-terminal domain
PF00704 (1/2) Glycosyl hydrolases family 18
PF00494 (1/2) Squalene/phytoene synthase
PF00348 (1/2) Polyprenyl synthetase
PF00005 (1/2) ABC transporter
precursor_groups_4422 148.18 +- 10.58 2 0 0 0 0.03 +- 0.02 2 6

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13545 (2/2) Crp-like helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_71383 46.14 +- 9.40 2 0 0 0 0.18 +- 0.21 2 17

TIGR00476 (2/2) selenide, water dikinase
TIGR00474 (2/2) L-seryl-tRNA(Sec) selenium transferase
PF13247 (2/2) 4Fe-4S dicluster domain
PF12838 (2/2) 4Fe-4S dicluster domain
PF12390 (2/2) Selenocysteine synthase N terminal
PF09107 (2/2) Elongation factor SelB, winged helix
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03916 (2/2) Polysulphide reductase, NrfD
PF03841 (2/2) L-seryl-tRNA selenium transferase
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00384 (2/2) Molybdopterin oxidoreductase
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF00005 (2/2) ABC transporter
TIGR00475 (1/2) selenocysteine-specific translation elongation factor
precursor_groups_52554 38.27 +- 1.42 2 0 0 0 0.05 +- 0.04 2 2

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_42266 316.69 +- 87.47 3 0 0 0 0.04 +- 0.03 3 10

PF15979 (3/3) Glycosyl hydrolase family 115
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00877 (3/3) NlpC/P60 family
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF17829 (2/3) Gylcosyl hydrolase family 115 C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
precursor_groups_3 86.54 +- 147.97 130 0 105 0 0.15 +- 0.23 130 11

PF03777 (130/130) ChpA-C
TIGR03025 (89/130) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (89/130) Glycosyl transferases group 1
PF13480 (89/130) Acetyltransferase (GNAT) domain
PF13439 (89/130) Glycosyltransferase Family 4
PF04932 (89/130) O-Antigen ligase
PF03023 (89/130) Lipid II flippase MurJ
PF02397 (89/130) Bacterial sugar transferase
PF01522 (89/130) Polysaccharide deacetylase
PF00534 (89/130) Glycosyl transferases group 1
PF00348 (73/130) Polyprenyl synthetase
precursor_groups_2 94.59 +- 140.31 76 0 15 2 0.12 +- 0.23 76 2

PF04149 (74/76) Domain of unknown function (DUF397)
PF13560 (64/76) Helix-turn-helix domain
precursor_groups_1 377.46 +- 891.35 59 0 9 11 0.09 +- 0.16 59 2

PF04149 (57/59) Domain of unknown function (DUF397)
PF13560 (31/59) Helix-turn-helix domain
precursor_groups_12191 236.78 +- 244.03 6 0 6 0 0.11 +- 0.24 6 24

TIGR01733 (6/6) amino acid adenylation domain
TIGR01686 (6/6) FkbH domain
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05977 (6/6) Transmembrane secretion effector
PF03621 (6/6) MbtH-like protein
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (6/6) Periplasmic binding protein
PF01032 (6/6) FecCD transport family
PF00975 (6/6) Thioesterase domain
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00005 (6/6) ABC transporter
PF07690 (5/6) Major Facilitator Superfamily
precursor_groups_12196 48.94 +- 21.31 5 0 0 0 0.18 +- 0.22 5 9

TIGR03718 (5/5) integral membrane protein, TerC family
PF05331 (5/5) Protein of unknown function (DUF742)
PF03741 (5/5) Integral membrane protein TerC family
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF18029 (4/5) Glyoxalase-like domain
PF13407 (4/5) Periplasmic binding protein domain
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_43645 25.15 +- 4.56 2 0 0 0 0.11 +- 0.13 2 4

PF09335 (2/2) SNARE associated Golgi protein
PF00248 (2/2) Aldo/keto reductase family
TIGR03395 (1/2) sphingomyelin phosphodiesterase
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
precursor_groups_5 70.38 +- 92.87 28 0 0 1 0.12 +- 0.22 28 2

PF04149 (27/28) Domain of unknown function (DUF397)
PF13560 (19/28) Helix-turn-helix domain
precursor_groups_4 46.62 +- 63.63 39 0 3 0 0.16 +- 0.24 39 2

PF04149 (38/39) Domain of unknown function (DUF397)
PF13560 (23/39) Helix-turn-helix domain
precursor_groups_30655 328.72 +- 190.80 4 0 0 0 0.02 +- 0.02 4 9

TIGR00167 (4/4) ketose-bisphosphate aldolase
PF17042 (4/4) Nucleotide-binding C-terminal domain
PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (4/4) GntP family permease
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00392 (4/4) Bacterial regulatory proteins, gntR family
precursor_groups_42466 160.63 +- 37.47 2 0 0 0 0.14 +- 0.22 2 20

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13464 (1/2) Domain of unknown function (DUF4115)
PF00271 (1/2) Helicase conserved C-terminal domain
PF00270 (1/2) DEAD/DEAH box helicase
PF00069 (1/2) Protein kinase domain
precursor_groups_2107 463.50 +- 30.17 2 0 1 0 0.04 +- 0.10 2 20

PF16861 (1/2) Carbamoyltransferase C-terminus
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13546 (1/2) DDE superfamily endonuclease
PF13463 (1/2) Winged helix DNA-binding domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07592 (1/2) Rhodopirellula transposase DDE domain
PF07510 (1/2) Protein of unknown function (DUF1524)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02729 (1/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02543 (1/2) Carbamoyltransferase N-terminus
PF01928 (1/2) CYTH domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01565 (1/2) FAD binding domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00224 (1/2) Pyruvate kinase, barrel domain
PF00185 (1/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (1/2) Beta-lactamase
precursor_groups_82867 304.17 +- 54.17 2 0 0 0 0.03 +- 0.04 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_67605 29.88 +- 1.21 2 0 0 0 0.13 +- 0.16 2 3

TIGR01755 (2/2) NAD(P)H:quinone oxidoreductase, type IV
PF08445 (2/2) FR47-like protein
PF03358 (2/2) NADPH-dependent FMN reductase
precursor_groups_18487 38.20 +- 0.50 2 0 0 0 0.10 +- 0.13 2 7

PF12728 (2/2) Helix-turn-helix domain
PF11750 (2/2) Protein of unknown function (DUF3307)
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF05707 (2/2) Zonular occludens toxin (Zot)
PF00589 (2/2) Phage integrase family
PF10935 (1/2) Protein of unknown function (DUF2637)
PF00293 (1/2) NUDIX domain
precursor_groups_26005 57.59 +- 39.16 2 0 0 0 0.10 +- 0.09 2 3

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF00067 (2/2) Cytochrome P450
precursor_groups_44722 55.28 +- 3.51 2 0 2 0 0.18 +- 0.16 2 10

PF18029 (2/2) Glyoxalase-like domain
PF18011 (2/2) C-terminal domain found in long catalases
PF13520 (2/2) Amino acid permease
PF13439 (2/2) Glycosyltransferase Family 4
PF06628 (2/2) Catalase-related immune-responsive
PF04101 (2/2) Glycosyltransferase family 28 C-terminal domain
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF00534 (2/2) Glycosyl transferases group 1
PF00199 (2/2) Catalase
PF00005 (2/2) ABC transporter
precursor_groups_8951 72.06 +- 53.82 7 2 0 0 0.14 +- 0.26 5 8

PF11758 (7/7) Aureocin-like type II bacteriocin
PF03372 (5/7) Endonuclease/Exonuclease/phosphatase family
PF02518 (5/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (5/7) D-alanyl-D-alanine carboxypeptidase
PF00672 (5/7) HAMP domain
PF00512 (5/7) His Kinase A (phospho-acceptor) domain
PF00486 (5/7) Transcriptional regulatory protein, C terminal
PF00072 (5/7) Response regulator receiver domain
precursor_groups_8952 182.98 +- 170.99 10 0 0 0 0.08 +- 0.07 10 7

PF08445 (10/10) FR47-like protein
PF00106 (10/10) short chain dehydrogenase
PF13531 (5/10) Bacterial extracellular solute-binding protein
PF08402 (5/10) TOBE domain
PF00694 (5/10) Aconitase C-terminal domain
PF00528 (5/10) Binding-protein-dependent transport system inner membrane component
PF00005 (5/10) ABC transporter
precursor_groups_8958 25.16 +- 8.72 3 0 0 0 0.14 +- 0.19 3 3

PF13649 (3/3) Methyltransferase domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (3/3) Major Facilitator Superfamily
precursor_groups_3707 1140.08 +- 802.11 20 2 18 20 0.04 +- 0.11 18 8

TIGR03897 (20/20) type 2 lantibiotic biosynthesis protein LanM
PF13575 (20/20) Domain of unknown function (DUF4135)
PF05147 (20/20) Lanthionine synthetase C-like protein
PF03412 (20/20) Peptidase C39 family
PF00664 (20/20) ABC transporter transmembrane region
PF00005 (20/20) ABC transporter
PF14867 (17/20) Lantibiotic alpha
PF12730 (16/20) ABC-2 family transporter protein
precursor_groups_74170 929.22 +- 318.78 2 0 0 0 0.01 +- 0.03 2 10

PF14307 (2/2) Glycosyltransferase WbsX
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01061 (2/2) ABC-2 type transporter
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_3703 26.07 +- 4.08 2 0 0 0 0.21 +- 0.25 2 21

PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
TIGR02434 (1/2) precorrin-6A synthase (deacetylating)
TIGR02257 (1/2) cobaltochelatase, CobN subunit
TIGR00715 (1/2) precorrin-6x reductase
TIGR00313 (1/2) cobyric acid synthase CobQ
TIGR00257 (1/2) uncharacterized protein, YigZ family
PF09186 (1/2) Domain of unknown function (DUF1949)
PF07685 (1/2) CobB/CobQ-like glutamine amidotransferase domain
PF07554 (1/2) FIVAR domain
PF04616 (1/2) Glycosyl hydrolases family 43
PF02571 (1/2) Precorrin-6x reductase CbiJ/CobK
PF02514 (1/2) CobN/Magnesium Chelatase
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01205 (1/2) Uncharacterized protein family UPF0029
PF00590 (1/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00498 (1/2) FHA domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00069 (1/2) Protein kinase domain
precursor_groups_5662 38.17 +- 3.77 2 0 0 0 0.11 +- 0.09 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_25585 20.57 +- 7.41 2 0 2 0 0.19 +- 0.27 2 10

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
TIGR04215 (1/2) choice-of-anchor A domain
PF17802 (1/2) Prealbumin-like fold domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13499 (1/2) EF-hand domain pair
PF05425 (1/2) Copper resistance protein D
PF01522 (1/2) Polysaccharide deacetylase
PF01471 (1/2) Putative peptidoglycan binding domain
precursor_groups_29975 1134.75 +- 490.59 4 0 0 0 0.01 +- 0.01 4 9

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF04686 (4/4) Streptomyces sporulation and cell division protein, SsgA
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_groups_49867 18.91 +- 0.00 2 0 0 0 0.11 +- 0.08 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07681 (2/2) DoxX
precursor_groups_17584 53.23 +- 35.55 6 0 0 0 0.08 +- 0.17 6 4

PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00067 (6/6) Cytochrome P450
precursor_groups_51079 103.84 +- 33.99 2 0 2 0 0.06 +- 0.13 2 14

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_23980 117.38 +- 3.56 2 0 0 0 0.03 +- 0.02 2 7

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13545 (2/2) Crp-like helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF00702 (1/2) haloacid dehalogenase-like hydrolase
precursor_groups_67910 62.67 +- 11.94 2 0 0 0 0.10 +- 0.14 2 7

PF13751 (2/2) Transposase DDE domain
PF12704 (2/2) MacB-like periplasmic core domain
PF05598 (2/2) Transposase domain (DUF772)
PF02687 (2/2) FtsX-like permease family
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_1851 104.27 +- 48.02 6 0 0 0 0.18 +- 0.31 6 25

TIGR03217 (6/6) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (6/6) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (6/6) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (6/6) 3-hydroxyanthranilate 3,4-dioxygenase
TIGR01814 (6/6) kynureninase
PF09290 (6/6) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08309 (6/6) LVIVD repeat
PF07836 (6/6) DmpG-like communication domain
PF06052 (6/6) 3-hydroxyanthranilic acid dioxygenase
PF04909 (6/6) Amidohydrolase
PF01590 (6/6) GAF domain
PF01557 (6/6) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (6/6) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (6/6) Endoribonuclease L-PSP
PF00682 (6/6) HMGL-like
PF00324 (6/6) Amino acid permease
PF00266 (6/6) Aminotransferase class-V
PF00171 (6/6) Aldehyde dehydrogenase family
PF07690 (4/6) Major Facilitator Superfamily
TIGR01728 (3/6) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF13649 (3/6) Methyltransferase domain
PF13379 (3/6) NMT1-like family
PF01903 (3/6) CbiX
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00005 (3/6) ABC transporter
precursor_groups_1857 254.54 +- 155.57 3 0 0 1 0.03 +- 0.04 3 6

PF13560 (3/3) Helix-turn-helix domain
PF00239 (3/3) Resolvase, N terminal domain
PF14279 (2/3) HNH endonuclease
PF13408 (2/3) Recombinase zinc beta ribbon domain
PF07508 (2/3) Recombinase
PF02796 (2/3) Helix-turn-helix domain of resolvase
precursor_groups_22101 111.82 +- 15.07 2 0 2 0 0.22 +- 0.29 2 7

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF03412 (2/2) Peptidase C39 family
PF01436 (2/2) NHL repeat
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_31913 1300.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13474 (2/2) SnoaL-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07729 (2/2) FCD domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_69635 22.49 +- 4.60 2 0 0 0 0.14 +- 0.07 2 5

TIGR02798 (2/2) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF04909 (2/2) Amidohydrolase
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_34434 86.65 +- 5.24 2 0 0 0 0.23 +- 0.31 2 8

TIGR03445 (2/2) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF12698 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF03995 (2/2) Peptidase inhibitor family I36
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_18390 789.47 +- 163.41 5 0 5 5 0.01 +- 0.02 5 9

TIGR04085 (5/5) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF08241 (5/5) Methyltransferase domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF01980 (5/5) tRNA-methyltransferase O
PF01494 (5/5) FAD binding domain
PF17920 (4/5) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/5) Bacterial regulatory proteins, tetR family
precursor_groups_22299 11.52 +- 3.85 3 0 0 0 0.19 +- 0.22 3 5

TIGR00537 (3/3) putative methylase
PF09360 (3/3) Iron-binding zinc finger CDGSH type
PF05175 (3/3) Methyltransferase small domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_groups_7469 389.28 +- 405.50 10 0 9 0 0.02 +- 0.01 10 8

PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01733 (9/10) amino acid adenylation domain
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF00501 (9/10) AMP-binding enzyme
PF12697 (8/10) Alpha/beta hydrolase family
precursor_groups_44042 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_groups_44736 458.00 +- 289.51 3 0 3 3 0.04 +- 0.09 3 10

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF12804 (3/3) MobA-like NTP transferase domain
PF04055 (3/3) Radical SAM superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02310 (3/3) B12 binding domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_63327 1034.00 +- 514.00 2 0 2 0 0.01 +- 0.00 2 11

TIGR01751 (2/2) crotonyl-CoA carboxylase/reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF07730 (1/2) Histidine kinase
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_11533 40.16 +- 13.53 5 0 0 0 0.11 +- 0.11 5 5

PF00877 (5/5) NlpC/P60 family
PF07728 (4/5) AAA domain (dynein-related subfamily)
PF07690 (4/5) Major Facilitator Superfamily
PF03771 (4/5) Domain of unknown function (DUF317)
PF00535 (4/5) Glycosyl transferase family 2
precursor_groups_44044 77.75 +- 5.18 2 0 0 0 0.04 +- 0.02 2 3

PF07883 (2/2) Cupin domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
precursor_groups_81 56.39 +- 26.42 13 0 3 0 0.15 +- 0.21 13

No common domains found
precursor_groups_83750 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_30245 104.39 +- 13.39 2 0 0 0 0.03 +- 0.02 2 7

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_8488 94.89 +- 16.17 10 0 0 0 0.07 +- 0.04 10 10

TIGR03570 (10/10) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03025 (10/10) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF17836 (10/10) PglD N-terminal domain
PF13313 (10/10) Domain of unknown function (DUF4082)
PF13205 (10/10) Bacterial Ig-like domain
PF02397 (10/10) Bacterial sugar transferase
PF01408 (10/10) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (10/10) NAD dependent epimerase/dehydratase family
PF01041 (10/10) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (9/10) Glycosyl transferase family 2
precursor_groups_71206 323.52 +- 31.02 2 0 2 0 0.02 +- 0.01 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
precursor_groups_3369 11.89 +- 1.35 2 0 0 0 0.17 +- 0.09 2 2

PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_3562 136.77 +- 60.08 12 0 0 0 0.18 +- 0.29 12 11

TIGR03177 (12/12) Flp pilus assembly protein CpaB
PF16976 (12/12) Flp pilus assembly protein RcpC/CpaB
PF13400 (12/12) Putative Flp pilus-assembly TadE/G-like
PF07811 (12/12) TadE-like protein
PF07730 (12/12) Histidine kinase
PF00691 (12/12) OmpA family
PF00482 (12/12) Type II secretion system (T2SS), protein F
PF00437 (12/12) Type II/IV secretion system protein
PF00196 (12/12) Bacterial regulatory proteins, luxR family
PF00072 (12/12) Response regulator receiver domain
PF13614 (10/12) AAA domain
precursor_groups_22857 255.55 +- 216.00 5 0 0 0 0.03 +- 0.03 5 4

PF04199 (5/5) Putative cyclase
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF02775 (4/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
precursor_groups_26758 461.93 +- 111.30 3 0 0 0 0.02 +- 0.05 3 10

TIGR01167 (3/3) LPXTG cell wall anchor domain
PF17802 (3/3) Prealbumin-like fold domain
PF16259 (3/3) Domain of unknown function (DUF4913)
PF12307 (3/3) Protein of unknown function (DUF3631)
PF08239 (3/3) Bacterial SH3 domain
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF01638 (3/3) HxlR-like helix-turn-helix
PF01555 (3/3) DNA methylase
PF00746 (2/3) LPXTG cell wall anchor motif
precursor_groups_7602 92.74 +- 70.19 5 0 0 0 0.08 +- 0.16 5 8

PF13244 (5/5) Domain of unknown function (DUF4040)
PF04039 (5/5) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (5/5) Na+/H+ antiporter subunit
PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (5/5) Proton-conducting membrane transporter
PF00106 (5/5) short chain dehydrogenase
PF04066 (4/5) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF01899 (4/5) Na+/H+ ion antiporter subunit
precursor_groups_64986 129.00 +- 0.00 2 0 2 2 0.02 +- 0.01 2 2

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
precursor_groups_80812 122.07 +- 0.00 2 0 0 0 0.09 +- 0.07 2 8

PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03537 (2/2) Glycoside-hydrolase family GH114
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_43733 153.45 +- 58.75 3 0 0 0 0.02 +- 0.02 3 2

PF04326 (3/3) Putative DNA-binding domain
PF00106 (3/3) short chain dehydrogenase
precursor_groups_12534 521.13 +- 304.47 2 0 0 0 0.03 +- 0.03 2 14

TIGR04364 (1/2) methyltransferase, FxLD system
PF13565 (1/2) Homeodomain-like domain
PF13358 (1/2) DDE superfamily endonuclease
PF13333 (1/2) Integrase core domain
PF12146 (1/2) Serine aminopeptidase, S33
PF07859 (1/2) alpha/beta hydrolase fold
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/2) FAD binding domain
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/2) Integrase core domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00144 (1/2) Beta-lactamase
precursor_groups_27751 69.23 +- 1.72 2 0 0 0 0.16 +- 0.27 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF04672 (2/2) S-adenosyl methyltransferase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00501 (2/2) AMP-binding enzyme
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
precursor_groups_66779 47.14 +- 1.61 2 0 0 0 0.04 +- 0.04 2 10

TIGR03351 (2/2) phosphonatase-like hydrolase
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF07702 (2/2) UTRA domain
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_18023 42.09 +- 3.31 3 0 0 0 0.22 +- 0.13 3 8

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13343 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF07690 (2/3) Major Facilitator Superfamily
precursor_groups_26356 129.33 +- 90.98 3 0 3 0 0.02 +- 0.02 3 2

PF00583 (3/3) Acetyltransferase (GNAT) family
PF00067 (3/3) Cytochrome P450
precursor_groups_82678 199.67 +- 32.53 2 0 0 0 0.02 +- 0.01 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_59163 846.72 +- 443.28 2 0 0 0 0.02 +- 0.01 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF07702 (2/2) UTRA domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
precursor_groups_15327 51.21 +- 6.05 3 0 0 0 0.08 +- 0.07 3 5

PF13649 (3/3) Methyltransferase domain
PF11706 (3/3) CGNR zinc finger
PF08445 (3/3) FR47-like protein
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07336 (3/3) Putative stress-induced transcription regulator
precursor_groups_4868 262.34 +- 76.06 15 1 2 0 0.01 +- 0.01 14 4

PF03412 (15/15) Peptidase C39 family
PF00664 (15/15) ABC transporter transmembrane region
PF00005 (15/15) ABC transporter
PF00535 (14/15) Glycosyl transferase family 2
precursor_groups_11338 432.00 +- 121.63 3 0 0 3 0.01 +- 0.00 3 3

TIGR00702 (3/3) YcaO-type kinase domain
PF07812 (3/3) TfuA-like protein
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_83411 102.01 +- 7.46 2 0 0 0 0.04 +- 0.03 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
precursor_groups_61726 22.54 +- 1.10 2 0 2 0 0.18 +- 0.24 2 5

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02525 (2/2) Flavodoxin-like fold
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_36763 52.15 +- 4.37 2 0 0 0 0.08 +- 0.06 2 6

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_22925 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily
precursor_groups_76933 67.88 +- 28.88 2 0 0 0 0.04 +- 0.03 2 4

TIGR00120 (2/2) glutamate N-acetyltransferase/amino-acid acetyltransferase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01960 (2/2) ArgJ family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_4264 56.16 +- 13.04 3 0 0 0 0.18 +- 0.34 3 9

PF13458 (3/3) Periplasmic binding protein
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF00501 (3/3) AMP-binding enzyme
PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF13676 (2/3) TIR domain
PF12399 (2/3) Branched-chain amino acid ATP-binding cassette transporter
PF00400 (2/3) WD domain, G-beta repeat
PF00248 (2/3) Aldo/keto reductase family
PF00005 (2/3) ABC transporter
precursor_groups_41322 451.12 +- 125.20 3 0 2 0 0.03 +- 0.03 3 10

PF14742 (3/3) N-terminal domain of (some) glycogen debranching enzymes
PF10282 (3/3) Lactonase, 7-bladed beta-propeller
PF07883 (3/3) Cupin domain
PF07729 (3/3) FCD domain
PF06202 (3/3) Amylo-alpha-1,6-glucosidase
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF03600 (3/3) Citrate transporter
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_7289 44.11 +- 2.29 7 0 0 0 0.21 +- 0.34 7 10

TIGR03177 (7/7) Flp pilus assembly protein CpaB
PF16976 (7/7) Flp pilus assembly protein RcpC/CpaB
PF13614 (7/7) AAA domain
PF07811 (7/7) TadE-like protein
PF00482 (7/7) Type II secretion system (T2SS), protein F
PF00437 (7/7) Type II/IV secretion system protein
PF00196 (6/7) Bacterial regulatory proteins, luxR family
PF00072 (6/7) Response regulator receiver domain
PF13400 (4/7) Putative Flp pilus-assembly TadE/G-like
PF00691 (4/7) OmpA family
precursor_groups_23434 338.00 +- 182.00 2 0 0 0 0.02 +- 0.06 2 10

PF07291 (2/2) Methylamine utilisation protein MauE
PF00717 (2/2) Peptidase S24-like
PF00005 (2/2) ABC transporter
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10502 (1/2) Signal peptidase, peptidase S26
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (1/2) FAD binding domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00578 (1/2) AhpC/TSA family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_4468 180.60 +- 77.40 2 0 0 0 0.01 +- 0.01 2 2

PF02547 (2/2) Queuosine biosynthesis protein
PF00106 (2/2) short chain dehydrogenase
precursor_groups_1149 91.06 +- 51.04 3 0 0 0 0.04 +- 0.04 3 5

TIGR03619 (2/3) probable F420-dependent oxidoreductase, Rv2161c family
PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF13560 (2/3) Helix-turn-helix domain
PF00296 (2/3) Luciferase-like monooxygenase
PF00106 (2/3) short chain dehydrogenase
precursor_groups_4466 47.20 +- 0.00 2 0 0 0 0.06 +- 0.07 2 7

TIGR00229 (2/2) PAS domain S-box protein
PF14342 (2/2) Domain of unknown function (DUF4396)
PF13426 (2/2) PAS domain
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00857 (2/2) Isochorismatase family
precursor_groups_1631 90.47 +- 60.82 44 0 0 0 0.06 +- 0.04 44 4

PF13738 (44/44) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (44/44) FMN-dependent dehydrogenase
PF00999 (44/44) Sodium/hydrogen exchanger family
PF00067 (44/44) Cytochrome P450
precursor_groups_40638 190.65 +- 2.85 2 0 2 0 0.05 +- 0.03 2 11

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF07993 (2/2) Male sterility protein
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01979 (2/2) Amidohydrolase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01040 (2/2) UbiA prenyltransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase
precursor_groups_15439 102.80 +- 2.15 2 0 0 0 0.04 +- 0.03 2 5

PF16259 (2/2) Domain of unknown function (DUF4913)
PF12696 (2/2) TraM recognition site of TraD and TraG
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01425 (2/2) Amidase
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_44557 158.00 +- 72.96 3 0 0 0 0.02 +- 0.01 3 2

PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF00293 (3/3) NUDIX domain
precursor_groups_81476 1089.14 +- 716.86 2 0 2 0 0.02 +- 0.02 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17874 (2/2) MalT-like TPR region
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
precursor_groups_21208 95.67 +- 9.64 2 0 0 2 0.05 +- 0.03 2 10

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/2) Glutamine amidotransferase domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02195 (2/2) ParB-like nuclease domain
PF00733 (2/2) Asparagine synthase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF00067 (2/2) Cytochrome P450
precursor_groups_65430 35.97 +- 0.14 2 0 0 0 0.08 +- 0.04 2 5

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
precursor_groups_10114 130.83 +- 75.85 4 0 0 0 0.02 +- 0.01 4 2

PF03795 (4/4) YCII-related domain
PF01425 (4/4) Amidase
precursor_groups_69747 172.30 +- 7.18 2 0 0 0 0.05 +- 0.04 2 5

PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04191 (2/2) Phospholipid methyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_15437 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family
precursor_groups_14123 239.74 +- 139.79 3 0 3 3 0.05 +- 0.04 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_2366 440.56 +- 238.32 20 0 0 20 0.03 +- 0.05 20 10

PF14833 (20/20) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (20/20) Glutamine amidotransferase domain
PF13480 (20/20) Acetyltransferase (GNAT) domain
PF07690 (20/20) Major Facilitator Superfamily
PF03641 (20/20) Possible lysine decarboxylase
PF03446 (20/20) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (20/20) N-terminal domain of galactosyltransferase
PF01041 (20/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (20/20) Asparagine synthase
PF00300 (20/20) Histidine phosphatase superfamily (branch 1)
precursor_groups_30889 37.34 +- 3.28 4 0 0 0 0.11 +- 0.13 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02781 (4/4) Glucose-6-phosphate dehydrogenase, C-terminal domain
PF00106 (4/4) short chain dehydrogenase
precursor_groups_9539 26.59 +- 10.34 2 0 0 0 0.23 +- 0.33 2 10

TIGR02094 (2/2) alpha-glucan phosphorylases
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF11897 (2/2) Protein of unknown function (DUF3417)
PF07730 (2/2) Histidine kinase
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00343 (2/2) Carbohydrate phosphorylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_groups_3967 54.93 +- 11.05 15 0 0 0 0.19 +- 0.15 15 6

PF02838 (15/15) Glycosyl hydrolase family 20, domain 2
PF01547 (15/15) Bacterial extracellular solute-binding protein
PF00728 (15/15) Glycosyl hydrolase family 20, catalytic domain
PF00722 (15/15) Glycosyl hydrolases family 16
PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF00942 (14/15) Cellulose binding domain
precursor_groups_27539 12.71 +- 4.49 2 0 0 0 0.18 +- 0.17 2 3

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_3962 20.46 +- 5.91 2 0 0 0 0.17 +- 0.37 2 9

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01694 (2/2) methylthioadenosine phosphorylase
TIGR00220 (2/2) large conductance mechanosensitive channel protein
PF09723 (2/2) Zinc ribbon domain
PF07690 (2/2) Major Facilitator Superfamily
PF01741 (2/2) Large-conductance mechanosensitive channel, MscL
PF01048 (2/2) Phosphorylase superfamily
TIGR01740 (1/2) orotidine 5'-phosphate decarboxylase
PF00215 (1/2) Orotidine 5'-phosphate decarboxylase / HUMPS family
precursor_groups_13873 71.55 +- 21.53 4 0 1 0 0.15 +- 0.17 4 8

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (4/4) virulence factor Mce family protein
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (4/4) Sigma-70, region 4
PF04542 (4/4) Sigma-70 region 2
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter
precursor_groups_762 57.50 +- 6.05 4 0 0 4 0.11 +- 0.12 4 6

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF13565 (4/4) Homeodomain-like domain
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF02954 (4/4) Bacterial regulatory protein, Fis family
PF01590 (4/4) GAF domain
PF00733 (4/4) Asparagine synthase
precursor_groups_765 128.79 +- 111.40 28 0 27 27 0.10 +- 0.22 28 5

TIGR03975 (28/28) ribosomal peptide maturation radical SAM protein 1
PF07690 (28/28) Major Facilitator Superfamily
PF02310 (28/28) B12 binding domain
PF00326 (28/28) Prolyl oligopeptidase family
PF04055 (27/28) Radical SAM superfamily
precursor_groups_59538 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01120 (2/2) Alpha-L-fucosidase
precursor_groups_36499 127.11 +- 87.55 3 0 3 0 0.05 +- 0.04 3 3

TIGR04538 (3/3) cytochrome P450, cyclodipeptide synthase-associated
PF00857 (3/3) Isochorismatase family
PF00067 (3/3) Cytochrome P450
precursor_groups_67176 378.02 +- 316.59 2 0 0 0 0.09 +- 0.25 2 7

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00857 (2/2) Isochorismatase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00144 (2/2) Beta-lactamase
precursor_groups_45170 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_groups_14454 451.50 +- 64.50 2 0 2 1 0.01 +- 0.00 2 8

PF14518 (1/2) Iron-containing redox enzyme
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (1/2) Radical SAM superfamily
PF02353 (1/2) Mycolic acid cyclopropane synthetase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family
precursor_groups_5029 164.28 +- 117.19 6 0 0 0 0.19 +- 0.30 6 11

TIGR03177 (6/6) Flp pilus assembly protein CpaB
PF16976 (6/6) Flp pilus assembly protein RcpC/CpaB
PF07811 (6/6) TadE-like protein
PF00691 (6/6) OmpA family
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
PF13614 (5/6) AAA domain
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF07730 (5/6) Histidine kinase
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain
precursor_groups_40417 351.80 +- 235.05 3 0 3 0 0.07 +- 0.23 3 7

PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF03949 (3/3) Malic enzyme, NAD binding domain
PF00975 (3/3) Thioesterase domain
PF00390 (3/3) Malic enzyme, N-terminal domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_groups_5021 36.02 +- 5.75 6 0 6 0 0.20 +- 0.17 6 8

PF11991 (6/6) Tryptophan dimethylallyltransferase
PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (6/6) Beta-eliminating lyase
PF00664 (5/6) ABC transporter transmembrane region
PF00005 (5/6) ABC transporter
precursor_groups_20297 120.70 +- 72.67 5 0 5 0 0.02 +- 0.01 5 2

PF11575 (5/5) FhuF 2Fe-2S C-terminal domain
PF04616 (5/5) Glycosyl hydrolases family 43
precursor_groups_15057 215.00 +- 71.67 2 0 2 0 0.02 +- 0.02 2 6

TIGR03105 (2/2) glutamine synthetase, type III
PF13522 (2/2) Glutamine amidotransferase domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01493 (2/2) GXGXG motif
PF01266 (2/2) FAD dependent oxidoreductase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_groups_9995 97.26 +- 83.02 8 0 0 0 0.12 +- 0.27 8 6

TIGR03086 (8/8) TIGR03086 family protein
PF14534 (8/8) Domain of unknown function (DUF4440)
PF11716 (8/8) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08002 (8/8) Protein of unknown function (DUF1697)
PF02983 (8/8) Alpha-lytic protease prodomain
PF00089 (8/8) Trypsin
precursor_groups_15051 94.51 +- 57.36 6 0 0 0 0.03 +- 0.02 6 1

PF01833 (6/6) IPT/TIG domain
precursor_groups_37702 54.17 +- 15.06 3 0 0 0 0.17 +- 0.28 3 12

TIGR01581 (3/3) NifC-like ABC-type porter
TIGR00638 (3/3) molybdenum-pterin binding domain
PF12770 (3/3) CHAT domain
PF12728 (3/3) Helix-turn-helix domain
PF10590 (3/3) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF03459 (3/3) TOBE domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01494 (3/3) FAD binding domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
precursor_groups_46601 61.37 +- 13.71 2 0 0 0 0.17 +- 0.33 2 13

TIGR02246 (2/2) conserved hypothetical protein
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF14478 (2/2) Domain of unknown function (DUF4430)
PF13649 (2/2) Methyltransferase domain
PF12822 (2/2) ECF transporter, substrate-specific component
PF04314 (2/2) Copper chaperone PCu(A)C
PF02361 (2/2) Cobalt transport protein
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_groups_9446 96.30 +- 21.23 9 0 9 0 0.13 +- 0.10 9 11

TIGR03860 (9/9) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (9/9) FMN reductase
TIGR00738 (9/9) Rrf2 family protein
PF13743 (9/9) Thioredoxin
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF03358 (9/9) NADPH-dependent FMN reductase
PF02082 (9/9) Transcriptional regulator
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (9/9) Luciferase-like monooxygenase
PF00005 (9/9) ABC transporter
precursor_groups_51372 530.00 +- 10.00 2 0 0 0 0.01 +- 0.01 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_groups_46973 207.00 +- 16.07 3 0 0 0 0.05 +- 0.07 3 16

PF11308 (3/3) Glycosyl hydrolases related to GH101 family, GH129
PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF04185 (3/3) Phosphoesterase family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00171 (3/3) Aldehyde dehydrogenase family
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450
precursor_groups_84428 1264.47 +- 1057.53 2 0 1 0 0.01 +- 0.01 2 20

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
TIGR03438 (1/2) dimethylhistidine N-methyltransferase
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18555 (1/2) MobL relaxases
PF18013 (1/2) Phage tail lysozyme
PF14528 (1/2) LAGLIDADG-like domain
PF12846 (1/2) AAA-like domain
PF12696 (1/2) TraM recognition site of TraD and TraG
PF12642 (1/2) Conjugative transposon protein TcpC
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF07724 (1/2) AAA domain (Cdc48 subfamily)
PF02534 (1/2) Type IV secretory system Conjugative DNA transfer
PF00562 (1/2) RNA polymerase Rpb2, domain 6
PF00216 (1/2) Bacterial DNA-binding protein
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_21905 285.47 +- 50.52 5 0 0 0 0.02 +- 0.03 5 9

TIGR01324 (5/5) cystathionine beta-lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF02786 (5/5) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01053 (5/5) Cys/Met metabolism PLP-dependent enzyme
PF00581 (5/5) Rhodanese-like domain
PF13229 (3/5) Right handed beta helix region
PF02655 (3/5) ATP-grasp domain
precursor_groups_21903 67.32 +- 32.20 5 0 0 0 0.07 +- 0.06 5 8

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12833 (5/5) Helix-turn-helix domain
PF06719 (5/5) AraC-type transcriptional regulator N-terminus
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00171 (5/5) Aldehyde dehydrogenase family
precursor_groups_11780 32.68 +- 0.44 3 0 0 0 0.12 +- 0.14 3 4

PF13701 (3/3) Transposase DDE domain group 1
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01476 (3/3) LysM domain
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_83305 377.27 +- 142.73 2 0 0 0 0.01 +- 0.01 2 6

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16990 (2/2) Carbohydrate binding module (family 35)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03595 (2/2) Voltage-dependent anion channel
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01055 (2/2) Glycosyl hydrolases family 31
precursor_groups_7848 117.23 +- 36.01 6 0 1 0 0.12 +- 0.26 6 14

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF04075 (6/6) F420H(2)-dependent quinone reductase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF01047 (6/6) MarR family
PF00999 (6/6) Sodium/hydrogen exchanger family
PF01613 (5/6) Flavin reductase like domain
PF01494 (5/6) FAD binding domain
PF00289 (4/6) Biotin carboxylase, N-terminal domain
PF02786 (3/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_groups_788 99.55 +- 52.81 5 0 4 0 0.12 +- 0.19 5 10

TIGR03885 (4/5) probable non-F420 flavinoid oxidoreductase
PF18306 (4/5) SLOG cluster4 family
PF16657 (4/5) Maltogenic Amylase, C-terminal domain
PF07690 (4/5) Major Facilitator Superfamily
PF03641 (4/5) Possible lysine decarboxylase
PF03067 (4/5) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (4/5) Polysaccharide deacetylase
PF00553 (4/5) Cellulose binding domain
PF00296 (4/5) Luciferase-like monooxygenase
PF00128 (4/5) Alpha amylase, catalytic domain
precursor_groups_62077 84.67 +- 18.80 2 0 1 0 0.15 +- 0.16 2 14

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF10518 (2/2) TAT (twin-arginine translocation) pathway signal sequence
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_59685 123.80 +- 33.22 2 0 2 2 0.17 +- 0.09 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_37944 36.01 +- 5.05 2 0 2 0 0.11 +- 0.13 2 4

PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00722 (2/2) Glycosyl hydrolases family 16
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_80785 630.67 +- 401.33 2 0 2 0 0.02 +- 0.01 2 5

PF08241 (2/2) Methyltransferase domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03795 (2/2) YCII-related domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (2/2) Condensation domain
precursor_groups_1450 370.18 +- 456.55 10 0 10 9 0.09 +- 0.25 10 6

PF00069 (10/10) Protein kinase domain
PF00005 (10/10) ABC transporter
PF06114 (9/10) IrrE N-terminal-like domain
PF05147 (9/10) Lanthionine synthetase C-like protein
PF02687 (9/10) FtsX-like permease family
PF00082 (9/10) Subtilase family
precursor_groups_4649 19.36 +- 2.27 5 0 5 0 0.16 +- 0.14 5 6

PF03450 (5/5) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (5/5) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (5/5) [2Fe-2S] binding domain
PF01315 (5/5) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (5/5) FAD binding domain in molybdopterin dehydrogenase
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_6719 30.61 +- 17.80 10 0 0 0 0.15 +- 0.22 10 5

PF14016 (10/10) Protein of unknown function (DUF4232)
PF03473 (10/10) MOSC domain
PF01636 (10/10) Phosphotransferase enzyme family
PF13560 (9/10) Helix-turn-helix domain
PF04149 (7/10) Domain of unknown function (DUF397)
precursor_groups_5737 240.22 +- 174.68 2 0 0 0 0.09 +- 0.07 2 13

TIGR03211 (2/2) catechol 2,3 dioxygenase
PF07729 (2/2) FCD domain
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01047 (2/2) MarR family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13672 (1/2) Protein phosphatase 2C
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF00400 (1/2) WD domain, G-beta repeat
precursor_groups_35846 361.61 +- 108.54 3 0 0 0 0.02 +- 0.01 3 8

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF06496 (3/3) Protein of unknown function (DUF1097)
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit
precursor_groups_45774 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_2423 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 5

PF12261 (2/2) Thermostable hemolysin
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_groups_23858 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain
precursor_groups_2424 192.76 +- 130.38 3 0 2 0 0.09 +- 0.20 3

No common domains found
precursor_groups_84821 34.25 +- 15.69 2 0 0 0 0.15 +- 0.31 2 10

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF02872 (2/2) 5'-nucleotidase, C-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
TIGR00838 (1/2) argininosuccinate lyase
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF04343 (1/2) Protein of unknown function, DUF488
PF00206 (1/2) Lyase
precursor_groups_64153 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter
precursor_groups_84823 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_5280 323.50 +- 63.50 2 0 0 0 0.01 +- 0.00 2 4

PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
TIGR00674 (1/2) 4-hydroxy-tetrahydrodipicolinate synthase
PF00701 (1/2) Dihydrodipicolinate synthetase family
precursor_groups_5287 9.28 +- 0.62 4 0 0 0 0.22 +- 0.16 4 3

PF13649 (4/4) Methyltransferase domain
PF07883 (4/4) Cupin domain
PF01381 (4/4) Helix-turn-helix
precursor_groups_38063 21.09 +- 7.73 2 0 0 0 0.17 +- 0.27 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13520 (2/2) Amino acid permease
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01590 (2/2) GAF domain
PF00989 (2/2) PAS fold
PF00741 (2/2) Gas vesicle protein
PF00083 (2/2) Sugar (and other) transporter
PF00005 (2/2) ABC transporter
precursor_groups_70686 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_49010 118.08 +- 8.88 2 0 0 0 0.18 +- 0.32 2 14

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF17853 (2/2) GGDEF-like domain
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF04188 (1/2) Mannosyltransferase (PIG-V)
precursor_groups_46772 133.23 +- 124.77 2 0 0 0 0.12 +- 0.16 2 6

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF07488 (2/2) Glycosyl hydrolase family 67 middle domain
PF07477 (2/2) Glycosyl hydrolase family 67 C-terminus
PF00754 (2/2) F5/8 type C domain
precursor_groups_37010 27.93 +- 1.01 2 0 0 0 0.22 +- 0.23 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_50158 87.43 +- 14.81 2 0 0 0 0.11 +- 0.12 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00069 (2/2) Protein kinase domain
precursor_groups_9663 191.78 +- 19.93 3 0 0 0 0.13 +- 0.24 3 14

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00223 (3/3) aspartate 1-decarboxylase
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02261 (3/3) Aspartate decarboxylase
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
PF14498 (2/3) Glycosyl hydrolase family 65, N-terminal domain
precursor_groups_367 60.63 +- 52.03 2 0 0 0 0.08 +- 0.17 2 18

TIGR00476 (1/2) selenide, water dikinase
TIGR00475 (1/2) selenocysteine-specific translation elongation factor
TIGR00474 (1/2) L-seryl-tRNA(Sec) selenium transferase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF12974 (1/2) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF12390 (1/2) Selenocysteine synthase N terminal
PF09107 (1/2) Elongation factor SelB, winged helix
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03841 (1/2) L-seryl-tRNA selenium transferase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00009 (1/2) Elongation factor Tu GTP binding domain
precursor_groups_360 270.80 +- 445.17 5 0 1 0 0.10 +- 0.25 5

No common domains found
precursor_groups_9667 34.70 +- 1.94 2 0 0 0 0.13 +- 0.14 2 8

PF07730 (2/2) Histidine kinase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00877 (2/2) NlpC/P60 family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF17829 (1/2) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (1/2) Glycosyl hydrolase family 115
precursor_groups_83236 454.06 +- 20.72 2 0 2 0 0.02 +- 0.02 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_28755 53.34 +- 5.07 4 0 0 0 0.21 +- 0.18 4 10

TIGR02429 (4/4) 3-oxoacid CoA-transferase, A subunit
TIGR02428 (4/4) 3-oxoacid CoA-transferase, B subunit
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF07883 (4/4) Cupin domain
PF04909 (4/4) Amidohydrolase
PF04199 (4/4) Putative cyclase
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (4/4) FAD binding domain
PF01144 (4/4) Coenzyme A transferase
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_28754 117.18 +- 80.32 4 0 0 0 0.11 +- 0.21 4 11

PF12833 (4/4) Helix-turn-helix domain
PF02774 (4/4) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (4/4) DJ-1/PfpI family
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00171 (4/4) Aldehyde dehydrogenase family
PF00696 (3/4) Amino acid kinase family
TIGR01296 (2/4) aspartate-semialdehyde dehydrogenase
PF14742 (2/4) N-terminal domain of (some) glycogen debranching enzymes
PF13830 (2/4) Domain of unknown function (DUF4192)
precursor_groups_17383 800.39 +- 557.23 3 0 0 0 0.03 +- 0.12 3 13

TIGR01122 (3/3) branched-chain amino acid aminotransferase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF11583 (3/3) P-aminobenzoate N-oxygenase AurF
PF07690 (3/3) Major Facilitator Superfamily
PF04339 (3/3) Peptidogalycan biosysnthesis/recognition
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF02222 (3/3) ATP-grasp domain
PF01063 (3/3) Amino-transferase class IV
PF01070 (2/3) FMN-dependent dehydrogenase
precursor_groups_4482 147.48 +- 74.59 17 0 1 0 0.02 +- 0.01 17 2

PF08241 (17/17) Methyltransferase domain
PF00067 (17/17) Cytochrome P450
precursor_groups_168 91.23 +- 44.86 3 0 0 0 0.11 +- 0.12 3

No common domains found
precursor_groups_47954 35.33 +- 9.33 2 0 2 0 0.09 +- 0.03 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_165 137.00 +- 192.16 11 0 2 0 0.05 +- 0.04 11 4

PF17074 (8/11) Darcynin, domain of unknown function
PF08021 (8/11) Siderophore-interacting FAD-binding domain
PF04954 (8/11) Siderophore-interacting protein
PF03446 (8/11) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_47950 185.98 +- 50.28 3 0 0 0 0.09 +- 0.07 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF12902 (3/3) Ferritin-like
PF04616 (3/3) Glycosyl hydrolases family 43
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_69336 2680.76 +- 157.24 2 0 2 0 0.01 +- 0.00 2 16

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10067 (2/2) Predicted membrane protein (DUF2306)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01757 (2/2) Acyltransferase family
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00144 (2/2) Beta-lactamase
precursor_groups_160 58.91 +- 34.91 2 0 0 0 0.07 +- 0.04 2 6

PF13602 (2/2) Zinc-binding dehydrogenase
PF08241 (2/2) Methyltransferase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
TIGR01552 (1/2) prevent-host-death family protein
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF02604 (1/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
precursor_groups_5606 71.62 +- 28.48 4 0 1 0 0.06 +- 0.06 4 8

PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00553 (4/4) Cellulose binding domain
TIGR01180 (3/4) putative alpha-1,2-mannosidase
PF17678 (3/4) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/4) Glycosyl hydrolase family 92
PF02518 (3/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/4) HAMP domain
PF00512 (3/4) His Kinase A (phospho-acceptor) domain
precursor_groups_10801 656.39 +- 462.45 5 0 5 0 0.07 +- 0.20 5 5

PF13649 (5/5) Methyltransferase domain
PF12697 (5/5) Alpha/beta hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
PF01593 (3/5) Flavin containing amine oxidoreductase
precursor_groups_2887 1560.00 +- 260.00 2 0 2 0 0.01 +- 0.00 2 17

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01261 (2/2) Xylose isomerase-like TIM barrel
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF12697 (1/2) Alpha/beta hydrolase family
PF07702 (1/2) UTRA domain
PF07690 (1/2) Major Facilitator Superfamily
PF06283 (1/2) Trehalose utilisation
PF01761 (1/2) 3-dehydroquinate synthase
PF01757 (1/2) Acyltransferase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00905 (1/2) Penicillin binding protein transpeptidase domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_groups_63615 13.01 +- 2.18 2 0 0 0 0.19 +- 0.06 2 3

PF00704 (2/2) Glycosyl hydrolases family 18
PF00082 (2/2) Subtilase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_groups_4424 12.41 +- 4.04 4 0 0 0 0.20 +- 0.20 4 6

PF10282 (4/4) Lactonase, 7-bladed beta-propeller
PF07702 (4/4) UTRA domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
TIGR03173 (2/4) xanthine permease
PF00860 (2/4) Permease family
PF00561 (2/4) alpha/beta hydrolase fold
precursor_groups_35939 255.53 +- 31.14 2 0 0 0 0.05 +- 0.11 2 9

PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF08125 (2/2) Mannitol dehydrogenase C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01232 (2/2) Mannitol dehydrogenase Rossmann domain
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_groups_80255 166.53 +- 14.34 2 0 2 0 0.07 +- 0.15 2 10

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF03861 (2/2) ANTAR domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00571 (2/2) CBS domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_2398 891.76 +- 855.62 6 0 6 0 0.04 +- 0.14 6 5

PF13649 (6/6) Methyltransferase domain
PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF12697 (6/6) Alpha/beta hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
precursor_groups_84222 159.00 +- 17.98 2 0 0 0 0.11 +- 0.16 2 21

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13380 (2/2) CoA binding domain
PF09084 (2/2) NMT1/THI5 like
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04016 (2/2) Putative heavy-metal chelation
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13549 (1/2) ATP-grasp domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00285 (1/2) Citrate synthase, C-terminal domain
precursor_groups_13295 17.22 +- 5.22 2 0 0 0 0.13 +- 0.12 2 6

PF13600 (2/2) N-terminal domain of unknown function (DUF4140)
PF13598 (2/2) Domain of unknown function (DUF4139)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain
TIGR02231 (1/2) conserved hypothetical protein
precursor_groups_30538 20.18 +- 2.70 3 0 0 0 0.20 +- 0.15 3 10

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13247 (3/3) 4Fe-4S dicluster domain
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_groups_181 475.68 +- 315.80 7 0 1 0 0.05 +- 0.13 7

No common domains found
precursor_groups_183 131.58 +- 94.35 9 0 8 0 0.03 +- 0.01 9 4

TIGR01509 (8/9) HAD hydrolase, family IA, variant 3
PF03756 (8/9) A-factor biosynthesis hotdog domain
PF00702 (8/9) haloacid dehalogenase-like hydrolase
PF00067 (8/9) Cytochrome P450
precursor_groups_32620 831.24 +- 728.76 2 0 2 2 0.06 +- 0.23 2 8

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF01061 (2/2) ABC-2 type transporter
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00160 (2/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00005 (2/2) ABC transporter
precursor_groups_2393 47.72 +- 21.39 2 0 1 0 0.18 +- 0.15 2 12

PF00005 (2/2) ABC transporter
PF18368 (1/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF17786 (1/2) Mannosidase Ig/CBM-like domain
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF11706 (1/2) CGNR zinc finger
PF07336 (1/2) Putative stress-induced transcription regulator
PF02225 (1/2) PA domain
PF00754 (1/2) F5/8 type C domain
PF00703 (1/2) Glycosyl hydrolases family 2
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family
precursor_groups_39634 47.33 +- 29.24 2 0 0 0 0.18 +- 0.13 2 14

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (2/2) FAD binding domain
PF00480 (2/2) ROK family
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07690 (1/2) Major Facilitator Superfamily
PF06182 (1/2) ABC-2 family transporter protein
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
precursor_groups_2396 896.34 +- 972.37 4 0 0 2 0.02 +- 0.03 4

No common domains found
precursor_groups_59574 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_46807 17.20 +- 4.91 2 0 2 0 0.12 +- 0.06 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_41270 25.24 +- 0.00 2 0 0 0 0.16 +- 0.10 2 5

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
PF13378 (2/2) Enolase C-terminal domain-like
PF02447 (2/2) GntP family permease
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_7188 136.13 +- 130.67 7 0 0 0 0.16 +- 0.21 7 7

PF07705 (6/7) CARDB
PF01547 (6/7) Bacterial extracellular solute-binding protein
PF00754 (6/7) F5/8 type C domain
PF00528 (6/7) Binding-protein-dependent transport system inner membrane component
PF00128 (6/7) Alpha amylase, catalytic domain
PF11941 (5/7) Domain of unknown function (DUF3459)
PF00583 (4/7) Acetyltransferase (GNAT) family
precursor_groups_9061 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_500 91.46 +- 272.54 22 0 1 1 0.17 +- 0.25 22 4

PF01145 (18/22) SPFH domain / Band 7 family
PF03067 (17/22) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00501 (13/22) AMP-binding enzyme
PF13193 (12/22) AMP-binding enzyme C-terminal domain
precursor_groups_504 311.04 +- 329.44 3 0 1 0 0.07 +- 0.13 3 10

PF13545 (2/3) Crp-like helix-turn-helix domain
PF13191 (2/3) AAA ATPase domain
PF07366 (2/3) SnoaL-like polyketide cyclase
PF03176 (2/3) MMPL family
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00899 (2/3) ThiF family
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00211 (2/3) Adenylate and Guanylate cyclase catalytic domain
PF00027 (2/3) Cyclic nucleotide-binding domain
precursor_groups_29576 207.33 +- 73.07 3 0 0 0 0.01 +- 0.01 3 2

PF07859 (3/3) alpha/beta hydrolase fold
PF01569 (3/3) PAP2 superfamily
precursor_groups_71640 551.25 +- 228.75 2 0 0 0 0.03 +- 0.07 2 15

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF04444 (2/2) Catechol dioxygenase N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00501 (2/2) AMP-binding enzyme
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00041 (2/2) Fibronectin type III domain
precursor_groups_17102 5432.92 +- 2546.80 4 0 4 4 0.02 +- 0.10 4 10

PF13732 (4/4) Domain of unknown function (DUF4162)
PF13649 (4/4) Methyltransferase domain
PF12698 (4/4) ABC-2 family transporter protein
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein
precursor_groups_59779 511.00 +- 91.00 2 0 0 0 0.01 +- 0.01 2 8

TIGR01722 (2/2) methylmalonate-semialdehyde dehydrogenase (acylating)
PF11534 (2/2) Hexameric tyrosine-coordinated heme protein (HTHP)
PF07690 (2/2) Major Facilitator Superfamily
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_2991 114.78 +- 35.75 6 0 0 5 0.23 +- 0.08 6 34

TIGR03026 (6/6) nucleotide sugar dehydrogenase
PF13857 (6/6) Ankyrin repeats (many copies)
PF13692 (6/6) Glycosyl transferases group 1
PF13579 (6/6) Glycosyl transferase 4-like domain
PF06628 (6/6) Catalase-related immune-responsive
PF03721 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (6/6) Chain length determinant protein
PF00984 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00199 (6/6) Catalase
TIGR01536 (5/6) asparagine synthase (glutamine-hydrolyzing)
PF16889 (5/6) Heparinase II/III N-terminus
PF16254 (5/6) Domain of unknown function (DUF4910)
PF16221 (5/6) winged helix-turn-helix
PF13537 (5/6) Glutamine amidotransferase domain
PF13489 (5/6) Methyltransferase domain
PF13439 (5/6) Glycosyltransferase Family 4
PF08484 (5/6) C-methyltransferase C-terminal domain
PF08421 (5/6) Putative zinc binding domain
PF07940 (5/6) Heparinase II/III-like protein
PF04230 (5/6) Polysaccharide pyruvyl transferase
PF02585 (5/6) GlcNAc-PI de-N-acetylase
PF01408 (5/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (5/6) NAD dependent epimerase/dehydratase family
PF00908 (5/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (5/6) Asparagine synthase
PF00535 (5/6) Glycosyl transferase family 2
PF00534 (5/6) Glycosyl transferases group 1
PF00202 (5/6) Aminotransferase class-III
PF00107 (5/6) Zinc-binding dehydrogenase
PF13229 (4/6) Right handed beta helix region
TIGR03025 (3/6) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (3/6) CoA-binding domain
PF02397 (3/6) Bacterial sugar transferase
precursor_groups_2774 281.60 +- 201.42 3 0 2 0 0.05 +- 0.07 3 1

PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
precursor_groups_3410 191.33 +- 9.33 2 0 0 0 0.01 +- 0.01 2 3

PF13560 (2/2) Helix-turn-helix domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_2086 93.31 +- 21.31 29 0 0 0 0.14 +- 0.25 29 11

TIGR00229 (29/29) PAS domain S-box protein
PF08795 (29/29) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (29/29) Animal haem peroxidase
PF02585 (29/29) GlcNAc-PI de-N-acetylase
PF01061 (29/29) ABC-2 type transporter
PF00989 (29/29) PAS fold
PF00933 (29/29) Glycosyl hydrolase family 3 N terminal domain
PF00582 (29/29) Universal stress protein family
PF00199 (29/29) Catalase
PF00196 (29/29) Bacterial regulatory proteins, luxR family
PF00005 (29/29) ABC transporter
precursor_groups_47605 632.96 +- 689.98 3 0 0 0 0.09 +- 0.20 3 9

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF05345 (3/3) Putative Ig domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (3/3) Proprotein convertase P-domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00664 (3/3) ABC transporter transmembrane region
PF00656 (3/3) Caspase domain
PF00005 (3/3) ABC transporter
precursor_groups_55169 228.36 +- 13.36 2 0 2 0 0.17 +- 0.30 2 24

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF18369 (1/2) Polyketide synthase dimerisation element domain
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13191 (1/2) AAA ATPase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_2083 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_987 50.17 +- 2.49 3 0 0 0 0.16 +- 0.33 3 7

TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR01550 (3/3) death-on-curing family protein
PF07690 (3/3) Major Facilitator Superfamily
PF05362 (3/3) Lon protease (S16) C-terminal proteolytic domain
PF02661 (3/3) Fic/DOC family
PF00082 (3/3) Subtilase family
PF04851 (2/3) Type III restriction enzyme, res subunit
precursor_groups_60513 120.91 +- 40.81 2 0 2 0 0.17 +- 0.23 2 12

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00704 (2/2) Glycosyl hydrolases family 18
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00722 (1/2) Glycosyl hydrolases family 16
PF00459 (1/2) Inositol monophosphatase family
precursor_groups_212 18.91 +- 0.28 3 0 0 0 0.11 +- 0.10 3 2

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF05685 (3/3) Putative restriction endonuclease
precursor_groups_213 132.57 +- 121.42 15 0 0 1 0.09 +- 0.15 15 2

PF14200 (8/15) Ricin-type beta-trefoil lectin domain-like
PF00652 (8/15) Ricin-type beta-trefoil lectin domain
precursor_groups_24625 782.71 +- 351.28 4 0 0 0 0.03 +- 0.04 4 11

PF18099 (4/4) DUF5010 C-terminal domain
PF13377 (4/4) Periplasmic binding protein-like domain
PF11941 (4/4) Domain of unknown function (DUF3459)
PF10756 (4/4) Bacterial PH domain
PF03663 (4/4) Glycosyl hydrolase family 76
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00128 (4/4) Alpha amylase, catalytic domain
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (3/4) Dehydratase family
precursor_groups_75237 130.01 +- 0.90 2 0 0 0 0.09 +- 0.16 2 8

TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00589 (2/2) Phage integrase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_219 21.94 +- 4.78 16 0 4 16 0.17 +- 0.23 16 5

TIGR04187 (16/16) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (16/16) putative ATP-grasp target RiPP
PF14404 (16/16) Ribosomally synthesized peptide in Streptomyces species
PF08242 (9/16) Methyltransferase domain
PF00903 (9/16) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_17615 655.79 +- 464.04 5 0 5 5 0.04 +- 0.14 5 14

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00630 (5/5) excinuclease ABC subunit A
PF17755 (5/5) UvrA DNA-binding domain
PF07730 (5/5) Histidine kinase
PF07690 (5/5) Major Facilitator Superfamily
PF06722 (5/5) Protein of unknown function (DUF1205)
PF04101 (5/5) Glycosyltransferase family 28 C-terminal domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00881 (5/5) Nitroreductase family
PF00190 (5/5) Cupin
precursor_groups_52633 1501.25 +- 318.75 2 0 2 2 0.01 +- 0.00 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
TIGR00032 (2/2) argininosuccinate synthase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00764 (2/2) Arginosuccinate synthase
PF00733 (2/2) Asparagine synthase
PF00668 (2/2) Condensation domain
PF00581 (2/2) Rhodanese-like domain
PF00578 (2/2) AhpC/TSA family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00206 (2/2) Lyase
PF04299 (1/2) Putative FMN-binding domain
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
precursor_groups_26914 268.55 +- 266.44 3 0 0 0 0.06 +- 0.12 3 5

TIGR03620 (3/3) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF12802 (3/3) MarR family
PF07859 (3/3) alpha/beta hydrolase fold
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_2170 13.36 +- 0.00 2 0 0 0 0.22 +- 0.33 2 8

TIGR02412 (2/2) aminopeptidase N
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13384 (2/2) Homeodomain-like domain
PF11838 (2/2) ERAP1-like C-terminal domain
PF04402 (2/2) Protein of unknown function (DUF541)
PF01433 (2/2) Peptidase family M1 domain
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
precursor_groups_22662 328.72 +- 190.80 4 0 0 0 0.02 +- 0.02 4 9

TIGR00167 (4/4) ketose-bisphosphate aldolase
PF17042 (4/4) Nucleotide-binding C-terminal domain
PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (4/4) GntP family permease
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00392 (4/4) Bacterial regulatory proteins, gntR family
precursor_groups_22661 148.01 +- 74.73 4 0 0 0 0.22 +- 0.28 4 19

TIGR00765 (4/4) YihY family inner membrane protein
TIGR00105 (4/4) ribosomal protein bL31
PF11941 (4/4) Domain of unknown function (DUF3459)
PF05922 (4/4) Peptidase inhibitor I9
PF03631 (4/4) Virulence factor BrkB
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01756 (4/4) Acyl-CoA oxidase
PF01497 (4/4) Periplasmic binding protein
PF01197 (4/4) Ribosomal protein L31
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00128 (4/4) Alpha amylase, catalytic domain
PF00082 (4/4) Subtilase family
PF07705 (3/4) CARDB
PF00754 (3/4) F5/8 type C domain
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF01032 (2/4) FecCD transport family
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00005 (2/4) ABC transporter
precursor_groups_43253 412.46 +- 267.73 3 0 2 0 0.04 +- 0.07 3 9

PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF13377 (2/3) Periplasmic binding protein-like domain
PF10022 (2/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (2/3) DeoR-like helix-turn-helix domain
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF01261 (2/3) Xylose isomerase-like TIM barrel
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_68425 304.14 +- 106.31 2 0 2 0 0.02 +- 0.03 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF04820 (2/2) Tryptophan halogenase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_17570 784.45 +- 536.54 5 0 0 0 0.03 +- 0.02 5 6

PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF08666 (3/5) SAF domain
precursor_groups_57829 277.15 +- 78.93 2 0 0 0 0.04 +- 0.06 2 10

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_groups_65519 181.59 +- 0.00 2 0 0 0 0.06 +- 0.08 2 10

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF13377 (2/2) Periplasmic binding protein-like domain
PF13205 (2/2) Bacterial Ig-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_55681 451.50 +- 193.50 2 0 2 0 0.01 +- 0.00 2 8

PF07883 (2/2) Cupin domain
PF01761 (2/2) 3-dehydroquinate synthase
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_52555 366.83 +- 20.17 2 0 2 0 0.01 +- 0.01 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_30234 43.69 +- 3.22 2 0 0 0 0.09 +- 0.08 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_19541 53.24 +- 23.79 5 0 5 0 0.09 +- 0.06 5 6

TIGR00797 (5/5) MATE efflux family protein
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (5/5) MatE
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
precursor_groups_18361 134.53 +- 90.94 3 0 0 0 0.03 +- 0.04 3 2

PF08877 (3/3) MepB protein
PF00501 (3/3) AMP-binding enzyme
precursor_groups_75018 569.60 +- 92.22 2 0 0 0 0.03 +- 0.02 2 15

TIGR00217 (2/2) 4-alpha-glucanotransferase
PF08323 (2/2) Starch synthase catalytic domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07883 (2/2) Cupin domain
PF06182 (2/2) ABC-2 family transporter protein
PF04321 (2/2) RmlD substrate binding domain
PF02446 (2/2) 4-alpha-glucanotransferase
PF01761 (2/2) 3-dehydroquinate synthase
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR01484 (1/2) HAD hydrolase, family IIB
TIGR00099 (1/2) Cof-like hydrolase
precursor_groups_19819 39.69 +- 13.37 2 0 0 0 0.19 +- 0.32 2 7

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_79477 1102.36 +- 187.64 2 0 0 0 0.02 +- 0.02 2 9

PF03706 (2/2) Lysylphosphatidylglycerol synthase TM region
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF03176 (2/2) MMPL family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01040 (2/2) UbiA prenyltransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00248 (2/2) Aldo/keto reductase family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_25170 191.07 +- 76.21 4 0 0 0 0.01 +- 0.01 4 2

PF13602 (4/4) Zinc-binding dehydrogenase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
precursor_groups_28299 313.28 +- 231.83 4 0 0 0 0.03 +- 0.04 4 6

TIGR01751 (4/4) crotonyl-CoA carboxylase/reductase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF01047 (4/4) MarR family
PF00857 (4/4) Isochorismatase family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_groups_38091 60.75 +- 34.52 3 0 0 0 0.09 +- 0.06 3 5

PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (3/3) Saccharopine dehydrogenase NADP binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01266 (3/3) FAD dependent oxidoreductase
precursor_groups_84559 51.53 +- 29.25 2 0 0 0 0.12 +- 0.20 2 5

PF14435 (2/2) SUKH-4 immunity protein
PF07690 (2/2) Major Facilitator Superfamily
PF01872 (2/2) RibD C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01206 (2/2) Sulfurtransferase TusA
precursor_groups_42674 255.64 +- 55.48 3 0 0 0 0.09 +- 0.22 3 21

TIGR01928 (3/3) o-succinylbenzoate synthase
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (3/3) Enolase C-terminal domain-like
PF12831 (3/3) FAD dependent oxidoreductase
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (3/3) CoA-transferase family III
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF01546 (3/3) Peptidase family M20/M25/M40
PF01381 (3/3) Helix-turn-helix
PF01380 (3/3) SIS domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_groups_25464 62.47 +- 18.15 2 0 0 0 0.05 +- 0.07 2 6

PF14100 (2/2) Methane oxygenase PmoA
PF13229 (2/2) Right handed beta helix region
PF07602 (2/2) Protein of unknown function (DUF1565)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_84552 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
precursor_groups_43390 976.74 +- 313.62 3 0 3 0 0.02 +- 0.03 3 5

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF01593 (3/3) Flavin containing amine oxidoreductase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_17805 31.74 +- 11.90 3 0 3 0 0.19 +- 0.30 3 19

TIGR02350 (3/3) chaperone protein DnaK
PF17765 (3/3) MmyB-like transcription regulator ligand binding domain
PF13560 (3/3) Helix-turn-helix domain
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF01025 (3/3) GrpE
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00067 (3/3) Cytochrome P450
PF00012 (3/3) Hsp70 protein
PF09129 (2/3) Cholesterol oxidase, substrate-binding
PF06386 (2/3) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/3) Gas vesicle synthesis protein GvpO
PF05121 (2/3) Gas vesicle protein K
PF05120 (2/3) Gas vesicle protein G
PF03364 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF02371 (2/3) Transposase IS116/IS110/IS902 family
PF01565 (2/3) FAD binding domain
PF01548 (2/3) Transposase
PF00741 (2/3) Gas vesicle protein
precursor_groups_22592 56.89 +- 19.03 4 0 0 0 0.13 +- 0.16 4 4

TIGR01484 (4/4) HAD hydrolase, family IIB
PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF04149 (4/4) Domain of unknown function (DUF397)
PF00353 (4/4) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_groups_44638 393.40 +- 239.84 3 0 3 0 0.12 +- 0.31 3 20

TIGR02039 (3/3) sulfate adenylyltransferase, small subunit
TIGR02034 (3/3) sulfate adenylyltransferase, large subunit
TIGR00670 (3/3) aspartate carbamoyltransferase
TIGR00455 (3/3) adenylyl-sulfate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01583 (3/3) Adenylylsulphate kinase
PF01507 (3/3) Phosphoadenosine phosphosulfate reductase family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00459 (3/3) Inositol monophosphatase family
PF00326 (3/3) Prolyl oligopeptidase family
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
PF00009 (3/3) Elongation factor Tu GTP binding domain
precursor_groups_22594 246.65 +- 115.26 5 0 4 0 0.08 +- 0.12 5 17

TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00550 (5/5) Phosphopantetheine attachment site
TIGR01746 (4/5) thioester reductase domain
TIGR01733 (4/5) amino acid adenylation domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF07993 (4/5) Male sterility protein
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00668 (4/5) Condensation domain
PF00501 (4/5) AMP-binding enzyme
PF00005 (4/5) ABC transporter
precursor_groups_19388 1067.58 +- 749.15 4 0 0 0 0.01 +- 0.00 4 7

TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
TIGR03919 (4/4) type VII secretion protein EccB
PF06259 (4/4) Alpha/beta hydrolase
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
TIGR03930 (2/4) WXG100 family type VII secretion target
PF06013 (2/4) Proteins of 100 residues with WXG
precursor_groups_76861 81.58 +- 1.73 2 0 0 0 0.17 +- 0.18 2 16

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13847 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
precursor_groups_22598 34.09 +- 15.72 3 0 0 0 0.17 +- 0.24 3 7

PF00082 (3/3) Subtilase family
PF00005 (3/3) ABC transporter
PF17964 (2/3) Bacterial Ig domain
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF03734 (2/3) L,D-transpeptidase catalytic domain
PF02687 (2/3) FtsX-like permease family
PF01152 (2/3) Bacterial-like globin
precursor_groups_2630 627.16 +- 526.35 5 0 5 2 0.03 +- 0.05 5 7

PF13527 (5/5) Acetyltransferase (GNAT) domain
PF07690 (5/5) Major Facilitator Superfamily
PF17668 (3/5) Acetyltransferase (GNAT) domain
PF13530 (3/5) Sterol carrier protein domain
PF00553 (3/5) Cellulose binding domain
PF00457 (3/5) Glycosyl hydrolases family 11
PF00069 (3/5) Protein kinase domain
precursor_groups_2515 339.13 +- 0.00 3 0 0 0 0.03 +- 0.01 3 8

TIGR00574 (3/3) DNA ligase I, ATP-dependent (dnl1)
PF04679 (3/3) ATP dependent DNA ligase C terminal region
PF04675 (3/3) DNA ligase N terminus
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01380 (3/3) SIS domain
PF01068 (3/3) ATP dependent DNA ligase domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_groups_59374 362.16 +- 87.26 2 0 1 2 0.09 +- 0.10 2 29

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF13586 (2/2) Transposase DDE domain
PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF17851 (1/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF14100 (1/2) Methane oxygenase PmoA
PF08279 (1/2) HTH domain
PF05331 (1/2) Protein of unknown function (DUF742)
PF04616 (1/2) Glycosyl hydrolases family 43
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01590 (1/2) GAF domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00723 (1/2) Glycosyl hydrolases family 15
PF00544 (1/2) Pectate lyase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_56660 1186.17 +- 232.83 2 0 2 2 0.01 +- 0.00 2 13

PF13580 (2/2) SIS domain
PF08544 (2/2) GHMP kinases C terminal
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF01761 (2/2) 3-dehydroquinate synthase
PF01555 (2/2) DNA methylase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01087 (2/2) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00288 (2/2) GHMP kinases N terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_42811 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_groups_6259 38.45 +- 2.83 2 0 1 1 0.11 +- 0.21 2 9

PF00069 (2/2) Protein kinase domain
PF14033 (1/2) Protein of unknown function (DUF4246)
PF05199 (1/2) GMC oxidoreductase
PF05147 (1/2) Lanthionine synthetase C-like protein
PF01734 (1/2) Patatin-like phospholipase
PF01590 (1/2) GAF domain
PF01425 (1/2) Amidase
PF00732 (1/2) GMC oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family
precursor_groups_6258 43.66 +- 3.32 5 0 0 0 0.23 +- 0.32 5 12

TIGR03177 (5/5) Flp pilus assembly protein CpaB
PF16976 (5/5) Flp pilus assembly protein RcpC/CpaB
PF13614 (5/5) AAA domain
PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF07730 (5/5) Histidine kinase
PF04964 (5/5) Flp/Fap pilin component
PF00691 (5/5) OmpA family
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
precursor_groups_6708 17.46 +- 8.51 3 0 2 0 0.17 +- 0.21 3 4

PF01061 (3/3) ABC-2 type transporter
PF00498 (3/3) FHA domain
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
precursor_groups_43381 30.89 +- 14.64 2 0 0 0 0.13 +- 0.13 2 4

TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00067 (1/2) Cytochrome P450
precursor_groups_73979 1281.00 +- 525.00 2 0 0 0 0.02 +- 0.02 2 9

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF06889 (2/2) Protein of unknown function (DUF1266)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_6701 382.54 +- 121.74 9 0 7 9 0.01 +- 0.00 9 4

PF07690 (9/9) Major Facilitator Superfamily
PF05711 (9/9) Macrocin-O-methyltransferase (TylF)
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF13649 (8/9) Methyltransferase domain
precursor_groups_78278 55.60 +- 12.20 2 0 2 0 0.17 +- 0.17 2 10

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_5499 156.60 +- 58.07 6 0 0 0 0.08 +- 0.13 6 7

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF07045 (6/6) Domain of unknown function (DUF1330)
PF01738 (6/6) Dienelactone hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00005 (6/6) ABC transporter
precursor_groups_75491 55.28 +- 3.51 2 0 2 0 0.18 +- 0.16 2 10

PF18029 (2/2) Glyoxalase-like domain
PF18011 (2/2) C-terminal domain found in long catalases
PF13520 (2/2) Amino acid permease
PF13439 (2/2) Glycosyltransferase Family 4
PF06628 (2/2) Catalase-related immune-responsive
PF04101 (2/2) Glycosyltransferase family 28 C-terminal domain
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF00534 (2/2) Glycosyl transferases group 1
PF00199 (2/2) Catalase
PF00005 (2/2) ABC transporter
precursor_groups_17972 375.81 +- 126.83 4 0 3 0 0.03 +- 0.04 4 14

TIGR03619 (4/4) probable F420-dependent oxidoreductase, Rv2161c family
PF14864 (4/4) Alkyl sulfatase C-terminal
PF13847 (4/4) Methyltransferase domain
PF07977 (4/4) FabA-like domain
PF03061 (4/4) Thioesterase superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF14863 (3/4) Alkyl sulfatase dimerisation
PF09076 (3/4) Beta/Gamma crystallin
PF00753 (3/4) Metallo-beta-lactamase superfamily
precursor_groups_42498 141.16 +- 40.59 3 0 0 0 0.03 +- 0.01 3 8

PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_8826 297.74 +- 56.52 4 0 0 0 0.10 +- 0.24 4 16

TIGR01902 (4/4) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (4/4) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (4/4) alpha-L-glutamate ligase, RimK family
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13535 (4/4) ATP-grasp domain
PF08443 (4/4) RimK-like ATP-grasp domain
PF07690 (4/4) Major Facilitator Superfamily
PF02779 (4/4) Transketolase, pyrimidine binding domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (4/4) Amino acid kinase family
PF00664 (4/4) ABC transporter transmembrane region
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
PF00005 (4/4) ABC transporter
precursor_groups_55868 774.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 12

TIGR04469 (2/2) CGA synthase-related protein
TIGR04468 (2/2) arginine 2,3-aminomutase
TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (2/2) cytosylglucuronate decarboxylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF12833 (2/2) Helix-turn-helix domain
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00069 (2/2) Protein kinase domain
precursor_groups_10810 164.13 +- 95.58 6 0 4 5 0.02 +- 0.02 6 2

PF00296 (6/6) Luciferase-like monooxygenase
PF05147 (5/6) Lanthionine synthetase C-like protein
precursor_groups_68646 131.16 +- 62.34 2 0 0 0 0.03 +- 0.03 2 4

PF18370 (2/2) Rhamnogalacturonan I lyases beta-sheet domain
PF10503 (2/2) Esterase PHB depolymerase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450
precursor_groups_52 45.71 +- 13.04 11 0 0 0 0.22 +- 0.38 11 6

PF05175 (9/11) Methyltransferase small domain
TIGR00041 (8/11) dTMP kinase
PF12840 (8/11) Helix-turn-helix domain
PF02223 (8/11) Thymidylate kinase
PF01061 (8/11) ABC-2 type transporter
PF00005 (8/11) ABC transporter
precursor_groups_18635 589.17 +- 92.80 2 0 2 0 0.03 +- 0.04 2 17

PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00106 (2/2) short chain dehydrogenase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16864 (1/2) Dimerisation domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF05598 (1/2) Transposase domain (DUF772)
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03704 (1/2) Bacterial transcriptional activator domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01738 (1/2) Dienelactone hydrolase family
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00072 (1/2) Response regulator receiver domain
precursor_groups_18141 83.61 +- 15.11 2 0 0 0 0.19 +- 0.16 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13410 (2/2) Glutathione S-transferase, C-terminal domain
PF08445 (2/2) FR47-like protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_18633 1256.88 +- 765.49 5 0 5 0 0.03 +- 0.10 5 15

TIGR01733 (5/5) amino acid adenylation domain
PF13560 (5/5) Helix-turn-helix domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF06368 (5/5) Methylaspartate mutase E chain (MutE)
PF03621 (5/5) MbtH-like protein
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (5/5) B12 binding domain
PF01648 (5/5) 4'-phosphopantetheinyl transferase superfamily
PF01645 (5/5) Conserved region in glutamate synthase
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00152 (5/5) tRNA synthetases class II (D, K and N)
precursor_groups_83016 2580.00 +- 0.00 2 0 2 2 0.01 +- 0.00 2 6

TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (2/2) ABC-2 type transporter
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
precursor_groups_3774 122.92 +- 7.08 2 0 1 0 0.06 +- 0.12 2 16

TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
TIGR01733 (1/2) amino acid adenylation domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18306 (1/2) SLOG cluster4 family
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF07730 (1/2) Histidine kinase
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01061 (1/2) ABC-2 type transporter
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (1/2) AMP-binding enzyme
PF00156 (1/2) Phosphoribosyl transferase domain
PF00005 (1/2) ABC transporter
precursor_groups_59378 71.47 +- 16.87 2 0 0 0 0.13 +- 0.09 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
precursor_groups_7073 635.55 +- 515.64 10 0 10 10 0.04 +- 0.18 10 7

TIGR03891 (10/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (10/10) Lantibiotic biosynthesis dehydratase C-term
PF05147 (10/10) Lanthionine synthetase C-like protein
PF04738 (10/10) Lantibiotic dehydratase, N terminus
PF00664 (8/10) ABC transporter transmembrane region
PF00005 (8/10) ABC transporter
PF13302 (7/10) Acetyltransferase (GNAT) domain
precursor_groups_49871 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_57463 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR01473 (2/2) protoheme IX farnesyltransferase
PF04261 (2/2) Dyp-type peroxidase family
PF01040 (2/2) UbiA prenyltransferase family
TIGR01413 (1/2) Dyp-type peroxidase family
precursor_groups_44971 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
precursor_groups_11897 174.14 +- 108.66 6 0 5 0 0.02 +- 0.02 6 4

PF10067 (6/6) Predicted membrane protein (DUF2306)
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF00107 (6/6) Zinc-binding dehydrogenase
PF00067 (6/6) Cytochrome P450
precursor_groups_43033 447.68 +- 277.08 3 0 2 0 0.03 +- 0.03 3 6

PF05426 (3/3) Alginate lyase
PF05345 (3/3) Putative Ig domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00295 (3/3) Glycosyl hydrolases family 28
PF00135 (2/3) Carboxylesterase family
precursor_groups_43031 463.67 +- 229.67 2 0 1 0 0.06 +- 0.11 2 12

PF13822 (1/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF03704 (1/2) Bacterial transcriptional activator domain
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (1/2) Phosphotransferase enzyme family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00067 (1/2) Cytochrome P450
precursor_groups_54791 670.50 +- 103.50 2 0 0 0 0.04 +- 0.04 2 7

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF01850 (2/2) PIN domain
PF00361 (2/2) Proton-conducting membrane transporter
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00146 (1/2) NADH dehydrogenase
precursor_groups_82520 33.33 +- 1.07 2 0 0 0 0.06 +- 0.01 2 1

PF00106 (2/2) short chain dehydrogenase
precursor_groups_22284 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily
precursor_groups_14872 56.27 +- 26.59 7 0 7 0 0.14 +- 0.18 7 6

PF11991 (7/7) Tryptophan dimethylallyltransferase
PF01212 (7/7) Beta-eliminating lyase
PF05331 (4/7) Protein of unknown function (DUF742)
PF03259 (4/7) Roadblock/LC7 domain
PF03029 (4/7) Conserved hypothetical ATP binding protein
PF02518 (4/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_11506 129.40 +- 68.70 2 0 0 0 0.10 +- 0.19 2 20

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01494 (2/2) FAD binding domain
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
PF13936 (1/2) Helix-turn-helix domain
PF13683 (1/2) Integrase core domain
PF13006 (1/2) Insertion element 4 transposase N-terminal
PF12900 (1/2) Pyridoxamine 5'-phosphate oxidase
PF12840 (1/2) Helix-turn-helix domain
PF03831 (1/2) PhnA domain
PF01740 (1/2) STAS domain
PF01609 (1/2) Transposase DDE domain
PF01527 (1/2) Transposase
PF00916 (1/2) Sulfate permease family
PF00665 (1/2) Integrase core domain
precursor_groups_34403 32.91 +- 4.54 2 0 2 0 0.19 +- 0.29 2 8

PF13410 (2/2) Glutathione S-transferase, C-terminal domain
PF13409 (2/2) Glutathione S-transferase, N-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF13230 (2/2) Glutamine amidotransferases class-II
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00722 (2/2) Glycosyl hydrolases family 16
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_10589 155.05 +- 102.95 2 0 2 0 0.04 +- 0.06 2 23

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08241 (2/2) Methyltransferase domain
PF07993 (2/2) Male sterility protein
PF01695 (2/2) IstB-like ATP binding protein
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00665 (2/2) Integrase core domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF03358 (1/2) NADPH-dependent FMN reductase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (1/2) Thioesterase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
precursor_groups_30255 87.84 +- 10.44 2 0 0 0 0.05 +- 0.07 2 9

PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF08002 (2/2) Protein of unknown function (DUF1697)
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01323 (2/2) DSBA-like thioredoxin domain
TIGR03086 (1/2) TIGR03086 family protein
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_groups_30257 48.73 +- 19.77 4 0 1 0 0.09 +- 0.09 4 4

PF11512 (4/4) Agrobacterium tumefaciens protein Atu4866
PF07690 (4/4) Major Facilitator Superfamily
PF01979 (4/4) Amidohydrolase family
PF07702 (3/4) UTRA domain
precursor_groups_30256 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 4

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF06325 (2/2) Ribosomal protein L11 methyltransferase (PrmA)
PF04149 (2/2) Domain of unknown function (DUF397)
precursor_groups_27955 63.27 +- 4.03 2 0 0 0 0.10 +- 0.12 2 5

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF02655 (1/2) ATP-grasp domain
precursor_groups_82777 559.00 +- 215.00 2 0 2 0 0.01 +- 0.01 2 10

PF13424 (2/2) Tetratricopeptide repeat
PF13394 (2/2) 4Fe-4S single cluster domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00931 (2/2) NB-ARC domain
PF00478 (2/2) IMP dehydrogenase / GMP reductase domain
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_86570 51.79 +- 15.31 2 0 0 0 0.17 +- 0.20 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_groups_10585 524.78 +- 612.66 9 0 9 0 0.05 +- 0.16 9 11

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
TIGR00652 (9/9) diaminopimelate epimerase
PF18130 (9/9) ATP-grasp N-terminal domain
PF14518 (9/9) Iron-containing redox enzyme
PF13535 (9/9) ATP-grasp domain
PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF10014 (9/9) 2OG-Fe dioxygenase
PF07690 (9/9) Major Facilitator Superfamily
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01678 (9/9) Diaminopimelate epimerase
PF00155 (9/9) Aminotransferase class I and II
precursor_groups_3602 451.91 +- 137.60 5 0 5 5 0.01 +- 0.01 5 6

TIGR04364 (5/5) methyltransferase, FxLD system
TIGR03891 (5/5) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF05147 (5/5) Lanthionine synthetase C-like protein
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF01135 (5/5) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_14082 205.39 +- 158.89 5 0 5 0 0.05 +- 0.04 5 13

PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/5) Acyl transferase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
TIGR04020 (4/5) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/5) amino acid adenylation domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF00668 (4/5) Condensation domain
PF00501 (4/5) AMP-binding enzyme
PF00296 (4/5) Luciferase-like monooxygenase
precursor_groups_28438 134.45 +- 23.20 3 0 3 0 0.08 +- 0.11 3 12

TIGR04498 (3/3) abortive infection protein, AbiV family
PF18728 (3/3) AbiV
PF03711 (3/3) Orn/Lys/Arg decarboxylase, C-terminal domain
PF03709 (3/3) Orn/Lys/Arg decarboxylase, N-terminal domain
PF02371 (3/3) Transposase IS116/IS110/IS902 family
PF01609 (3/3) Transposase DDE domain
PF01548 (3/3) Transposase
PF01276 (3/3) Orn/Lys/Arg decarboxylase, major domain
PF00494 (3/3) Squalene/phytoene synthase
PF00348 (3/3) Polyprenyl synthetase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
precursor_groups_22846 148.56 +- 106.11 5 0 0 5 0.10 +- 0.14 5 16

TIGR04283 (5/5) transferase 2, rSAM/selenodomain-associated
TIGR04282 (5/5) transferase 1, rSAM/selenodomain-associated
PF12850 (5/5) Calcineurin-like phosphoesterase superfamily domain
PF09837 (5/5) Uncharacterized protein conserved in bacteria (DUF2064)
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04055 (5/5) Radical SAM superfamily
PF02852 (5/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF02687 (5/5) FtsX-like permease family
PF01048 (5/5) Phosphorylase superfamily
PF00535 (5/5) Glycosyl transferase family 2
PF00005 (5/5) ABC transporter
PF00672 (4/5) HAMP domain
PF00512 (4/5) His Kinase A (phospho-acceptor) domain
PF00486 (4/5) Transcriptional regulatory protein, C terminal
PF00072 (4/5) Response regulator receiver domain
PF07291 (3/5) Methylamine utilisation protein MauE
precursor_groups_53315 258.43 +- 108.63 2 0 0 0 0.04 +- 0.04 2 7

PF14525 (2/2) AraC-binding-like domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_3594 526.85 +- 513.15 2 0 1 0 0.08 +- 0.16 2 24

TIGR02149 (1/2) glycogen synthase, Corynebacterium family
TIGR02091 (1/2) glucose-1-phosphate adenylyltransferase
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00838 (1/2) argininosuccinate lyase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF13535 (1/2) ATP-grasp domain
PF13439 (1/2) Glycosyltransferase Family 4
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF06276 (1/2) Ferric iron reductase FhuF-like transporter
PF03621 (1/2) MbtH-like protein
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00483 (1/2) Nucleotidyl transferase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00288 (1/2) GHMP kinases N terminal domain
PF00206 (1/2) Lyase
precursor_groups_3597 68.65 +- 72.99 5 0 0 0 0.08 +- 0.09 5 4

PF14200 (5/5) Ricin-type beta-trefoil lectin domain-like
PF09997 (5/5) Predicted membrane protein (DUF2238)
PF05270 (5/5) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (5/5) Glycosyl hydrolases family 43
precursor_groups_29818 650.81 +- 12.62 2 0 0 0 0.01 +- 0.01 2 5

PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_65234 239.03 +- 147.97 2 0 1 0 0.02 +- 0.03 2 3

PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF07690 (2/2) Major Facilitator Superfamily
PF00487 (2/2) Fatty acid desaturase
precursor_groups_44991 1206.67 +- 117.85 3 0 3 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF05114 (3/3) Protein of unknown function (DUF692)
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF06999 (2/3) Sucrase/ferredoxin-like
precursor_groups_71105 777.00 +- 3.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00067 (2/2) Cytochrome P450
precursor_groups_6671 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_12528 119.62 +- 68.02 2 0 0 0 0.05 +- 0.07 2 6

PF14759 (2/2) Reductase C-terminal
PF13459 (2/2) 4Fe-4S single cluster domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01636 (2/2) Phosphotransferase enzyme family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_43727 62.67 +- 21.49 3 0 0 0 0.09 +- 0.12 3 6

PF13378 (3/3) Enolase C-terminal domain-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_23225 93.60 +- 84.83 2 0 0 0 0.15 +- 0.14 2 7

TIGR01048 (2/2) diaminopimelate decarboxylase
PF04616 (2/2) Glycosyl hydrolases family 43
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF17851 (1/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10
precursor_groups_7277 206.03 +- 75.99 7 0 2 5 0.06 +- 0.11 7 4

PF04828 (4/7) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (4/7) Amidinotransferase
PF00999 (4/7) Sodium/hydrogen exchanger family
PF00881 (4/7) Nitroreductase family
precursor_groups_66987 27.36 +- 2.87 2 0 0 0 0.11 +- 0.06 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_4817 283.90 +- 336.53 15 0 0 0 0.09 +- 0.22 15 12

PF03706 (15/15) Lysylphosphatidylglycerol synthase TM region
PF03372 (15/15) Endonuclease/Exonuclease/phosphatase family
PF01370 (15/15) NAD dependent epimerase/dehydratase family
PF01040 (15/15) UbiA prenyltransferase family
PF00535 (15/15) Glycosyl transferase family 2
PF00248 (15/15) Aldo/keto reductase family
PF00202 (15/15) Aminotransferase class-III
PF00196 (15/15) Bacterial regulatory proteins, luxR family
PF11755 (9/15) Protein of unknown function (DUF3311)
PF00583 (9/15) Acetyltransferase (GNAT) family
PF00474 (9/15) Sodium:solute symporter family
PF03176 (8/15) MMPL family
precursor_groups_66981 405.53 +- 129.77 2 0 2 0 0.03 +- 0.04 2 18

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01063 (2/2) Amino-transferase class IV
PF00850 (2/2) Histone deacetylase domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00425 (2/2) chorismate binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_groups_59171 148.71 +- 51.96 2 0 0 0 0.05 +- 0.05 2 6

PF14279 (2/2) HNH endonuclease
PF13560 (2/2) Helix-turn-helix domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF07508 (2/2) Recombinase
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF00239 (2/2) Resolvase, N terminal domain
precursor_groups_15331 127.39 +- 21.46 2 0 0 0 0.12 +- 0.18 2 15

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13407 (2/2) Periplasmic binding protein domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04199 (2/2) Putative cyclase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF00575 (1/2) S1 RNA binding domain
precursor_groups_65298 126.63 +- 34.90 2 0 2 0 0.12 +- 0.15 2 7

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_10742 188.27 +- 75.50 4 0 0 0 0.06 +- 0.04 4 8

PF13416 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00266 (4/4) Aminotransferase class-V
PF17831 (2/4) Pyruvate dehydrogenase E1 component middle domain
PF12697 (2/4) Alpha/beta hydrolase family
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF02467 (2/4) Transcription factor WhiB
PF00456 (2/4) Transketolase, thiamine diphosphate binding domain
precursor_groups_54136 322.67 +- 93.33 2 0 0 0 0.01 +- 0.01 2 4

PF12006 (2/2) Protein of unknown function (DUF3500)
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_61750 532.30 +- 265.64 2 0 2 0 0.12 +- 0.26 2 28

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
TIGR00223 (2/2) aspartate 1-decarboxylase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13847 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF13358 (2/2) DDE superfamily endonuclease
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF02261 (2/2) Aspartate decarboxylase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_9851 126.89 +- 24.86 7 0 4 0 0.03 +- 0.02 7 6

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF07690 (7/7) Major Facilitator Superfamily
PF01238 (7/7) Phosphomannose isomerase type I
PF00282 (7/7) Pyridoxal-dependent decarboxylase conserved domain
PF07729 (4/7) FCD domain
PF00392 (4/7) Bacterial regulatory proteins, gntR family
precursor_groups_9857 630.67 +- 254.09 3 0 0 0 0.03 +- 0.03 3 14

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF02449 (3/3) Beta-galactosidase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00135 (3/3) Carboxylesterase family
PF16499 (2/3) Alpha galactosidase A
PF14508 (2/3) Glycosyl-hydrolase 97 N-terminal
PF06964 (2/3) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/3) Glycosyl hydrolases family 43
precursor_groups_48435 40.66 +- 1.66 2 0 2 0 0.15 +- 0.31 2 9

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_22932 176.42 +- 64.15 5 0 0 0 0.07 +- 0.05 5 8

PF13416 (5/5) Bacterial extracellular solute-binding protein
PF01266 (5/5) FAD dependent oxidoreductase
PF00005 (5/5) ABC transporter
TIGR01428 (4/5) haloacid dehalogenase, type II
PF13419 (4/5) Haloacid dehalogenase-like hydrolase
PF08402 (4/5) TOBE domain
PF00528 (4/5) Binding-protein-dependent transport system inner membrane component
PF00171 (4/5) Aldehyde dehydrogenase family
precursor_groups_70675 410.42 +- 115.12 2 0 0 0 0.03 +- 0.04 2 16

TIGR00872 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14433 (2/2) SUKH-3 immunity protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13401 (2/2) AAA domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF06527 (2/2) TniQ
PF06414 (2/2) Zeta toxin
PF04199 (2/2) Putative cyclase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00665 (2/2) Integrase core domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_59213 364.31 +- 25.69 2 0 0 0 0.01 +- 0.00 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_62249 72.56 +- 4.84 2 0 2 0 0.10 +- 0.21 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_62248 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_13224 75.22 +- 56.18 5 0 5 0 0.06 +- 0.06 5 2

PF00156 (5/5) Phosphoribosyl transferase domain
PF00082 (5/5) Subtilase family
precursor_groups_1607 135.29 +- 122.71 2 0 0 0 0.08 +- 0.11 2 5

PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF01477 (1/2) PLAT/LH2 domain
PF01341 (1/2) Glycosyl hydrolases family 6
PF00106 (1/2) short chain dehydrogenase
precursor_groups_62240 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_1605 17.02 +- 3.24 5 0 0 0 0.17 +- 0.16 5 7

TIGR01840 (3/5) esterase, PHB depolymerase family
PF13701 (3/5) Transposase DDE domain group 1
PF10605 (3/5) 3HB-oligomer hydrolase (3HBOH)
PF10503 (3/5) Esterase PHB depolymerase
PF07519 (3/5) Tannase and feruloyl esterase
PF00144 (3/5) Beta-lactamase
PF00041 (3/5) Fibronectin type III domain
precursor_groups_20752 658.02 +- 501.26 5 0 5 0 0.05 +- 0.17 5 8

TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08242 (5/5) Methyltransferase domain
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
precursor_groups_23358 140.30 +- 117.70 2 0 0 0 0.05 +- 0.07 2 2

PF10056 (2/2) Uncharacterized conserved protein (DUF2293)
PF08592 (2/2) Domain of unknown function (DUF1772)
precursor_groups_64907 595.60 +- 307.40 2 0 0 0 0.03 +- 0.07 2 16

PF18448 (2/2) Carbohydrate binding domain
PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (2/2) Domain of unknown function(DUF4981)
PF15902 (2/2) Sortilin, neurotensin receptor 3,
PF14310 (2/2) Fibronectin type III-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF04616 (2/2) Glycosyl hydrolases family 43
PF03442 (2/2) Carbohydrate binding domain X2
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (2/2) Alpha-L-fucosidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_11764 276.38 +- 115.50 6 0 6 0 0.03 +- 0.13 6 9

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00891 (6/6) O-methyltransferase domain
precursor_groups_11765 22.50 +- 3.18 5 0 0 0 0.18 +- 0.17 5 5

PF13564 (5/5) DoxX-like family
PF11139 (5/5) Sap, sulfolipid-1-addressing protein
PF07690 (5/5) Major Facilitator Superfamily
PF04029 (5/5) 2-phosphosulpholactate phosphatase
PF01494 (5/5) FAD binding domain
precursor_groups_20994 916.95 +- 819.52 3 0 0 0 0.02 +- 0.02 3 11

PF13814 (2/3) Replication-relaxation
PF13406 (2/3) Transglycosylase SLT domain
PF13400 (2/3) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/3) AAA-like domain
PF12642 (2/3) Conjugative transposon protein TcpC
PF08666 (2/3) SAF domain
PF07811 (2/3) TadE-like protein
PF01476 (2/3) LysM domain
PF00877 (2/3) NlpC/P60 family
PF00482 (2/3) Type II secretion system (T2SS), protein F
PF00437 (2/3) Type II/IV secretion system protein
precursor_groups_44568 42.04 +- 0.96 2 0 0 0 0.12 +- 0.12 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02156 (2/2) Glycosyl hydrolase family 26
PF01943 (2/2) Polysaccharide biosynthesis protein
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00005 (2/2) ABC transporter
precursor_groups_90 496.25 +- 1000.57 6 0 2 0 0.10 +- 0.23 6 3

PF04149 (6/6) Domain of unknown function (DUF397)
PF13560 (5/6) Helix-turn-helix domain
PF04672 (5/6) S-adenosyl methyltransferase
precursor_groups_64908 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_82797 107.56 +- 6.94 2 0 2 0 0.13 +- 0.23 2 12

PF13924 (2/2) Lipocalin-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04673 (2/2) Polyketide synthesis cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF17754 (1/2) MftR C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_34577 117.22 +- 27.91 2 0 2 0 0.05 +- 0.06 2 13

TIGR01426 (2/2) glycosyltransferase, MGT family
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00664 (2/2) ABC transporter transmembrane region
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_41719 161.20 +- 98.80 2 0 0 0 0.02 +- 0.04 2 6

PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
PF00069 (2/2) Protein kinase domain
precursor_groups_61193 106.96 +- 34.94 2 0 0 0 0.07 +- 0.03 2 13

PF17645 (2/2) Arylmalonate decarboxylase
PF12697 (2/2) Alpha/beta hydrolase family
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01494 (2/2) FAD binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (2/2) MarR family
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00857 (2/2) Isochorismatase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_41714 186.14 +- 8.86 2 0 0 0 0.03 +- 0.01 2 9

PF13808 (2/2) DDE_Tnp_1-associated
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01609 (2/2) Transposase DDE domain
PF01596 (2/2) O-methyltransferase
PF01494 (2/2) FAD binding domain
PF00581 (2/2) Rhodanese-like domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_14115 18.88 +- 3.69 5 0 0 0 0.22 +- 0.20 5 19

TIGR03346 (5/5) ATP-dependent chaperone protein ClpB
TIGR02350 (5/5) chaperone protein DnaK
TIGR01068 (5/5) thioredoxin
PF17871 (5/5) AAA lid domain
PF13591 (5/5) MerR HTH family regulatory protein
PF13515 (5/5) Fusaric acid resistance protein-like
PF12805 (5/5) FUSC-like inner membrane protein yccS
PF10431 (5/5) C-terminal, D2-small domain, of ClpB protein
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (5/5) AAA domain (Cdc48 subfamily)
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF02148 (5/5) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (5/5) DnaJ C terminal domain
PF01025 (5/5) GrpE
PF00226 (5/5) DnaJ domain
PF00085 (5/5) Thioredoxin
PF00027 (5/5) Cyclic nucleotide-binding domain
PF00012 (5/5) Hsp70 protein
PF00004 (5/5) ATPase family associated with various cellular activities (AAA)
precursor_groups_81684 24.72 +- 1.08 2 0 0 0 0.16 +- 0.23 2 9

TIGR01031 (2/2) ribosomal protein bL32
PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (2/2) Ribosomal L32p protein family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_groups_41712 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_1286 57.33 +- 77.68 7 0 1 0 0.15 +- 0.26 7

No common domains found
precursor_groups_66574 146.17 +- 19.69 2 0 2 0 0.04 +- 0.02 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_49097 107.64 +- 9.63 2 0 2 0 0.09 +- 0.23 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13424 (2/2) Tetratricopeptide repeat
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12770 (2/2) CHAT domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07681 (2/2) DoxX
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13808 (1/2) DDE_Tnp_1-associated
PF13545 (1/2) Crp-like helix-turn-helix domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01609 (1/2) Transposase DDE domain
precursor_groups_1282 174.56 +- 122.08 24 0 24 24 0.05 +- 0.03 24 5

TIGR04451 (24/24) lantipeptide, SCO0268 family
TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (24/24) Lantibiotic biosynthesis dehydratase C-term
PF05147 (24/24) Lanthionine synthetase C-like protein
PF04738 (24/24) Lantibiotic dehydratase, N terminus
precursor_groups_29741 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
precursor_groups_62407 172.67 +- 0.67 2 0 2 0 0.01 +- 0.00 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_10463 746.09 +- 12.83 2 0 0 0 0.02 +- 0.02 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_groups_44961 1544.36 +- 534.84 3 0 3 3 0.01 +- 0.01 3 9

PF12730 (3/3) ABC-2 family transporter protein
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF00465 (2/3) Iron-containing alcohol dehydrogenase
PF00296 (2/3) Luciferase-like monooxygenase
PF00202 (2/3) Aminotransferase class-III
precursor_groups_21578 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family
precursor_groups_45163 14.51 +- 0.00 2 0 0 0 0.21 +- 0.10 2 6

TIGR00342 (2/2) tRNA sulfurtransferase ThiI
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02926 (2/2) THUMP domain
PF02568 (2/2) Thiamine biosynthesis protein (ThiI)
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_29585 1343.28 +- 978.72 2 0 0 0 0.02 +- 0.02 2 13

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/2) AAA-like domain
PF12642 (2/2) Conjugative transposon protein TcpC
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00877 (2/2) NlpC/P60 family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF13560 (1/2) Helix-turn-helix domain
PF13406 (1/2) Transglycosylase SLT domain
PF00691 (1/2) OmpA family
precursor_groups_817 26.89 +- 5.88 7 0 0 0 0.16 +- 0.20 7 5

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF08044 (7/7) Domain of unknown function (DUF1707)
PF07690 (7/7) Major Facilitator Superfamily
PF00440 (7/7) Bacterial regulatory proteins, tetR family
PF00067 (7/7) Cytochrome P450
precursor_groups_15041 299.90 +- 133.27 4 0 0 0 0.06 +- 0.10 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_8102 25.12 +- 7.13 2 0 0 0 0.12 +- 0.19 2 6

PF17935 (1/2) Tetracyclin repressor-like, C-terminal domain
PF06751 (1/2) Ethanolamine ammonia lyase large subunit (EutB)
PF05985 (1/2) Ethanolamine ammonia-lyase light chain (EutC)
PF01636 (1/2) Phosphotransferase enzyme family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_8453 592.38 +- 294.18 3 0 3 0 0.08 +- 0.22 3 5

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF01593 (2/3) Flavin containing amine oxidoreductase
precursor_groups_27417 76.51 +- 41.30 4 0 4 0 0.05 +- 0.06 4 7

PF12728 (4/4) Helix-turn-helix domain
PF07995 (4/4) Glucose / Sorbosone dehydrogenase
PF06283 (4/4) Trehalose utilisation
PF03422 (4/4) Carbohydrate binding module (family 6)
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00801 (4/4) PKD domain
PF00589 (4/4) Phage integrase family
precursor_groups_20192 109.46 +- 5.44 5 0 0 0 0.12 +- 0.30 5 11

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (5/5) argininosuccinate lyase
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF03972 (5/5) MmgE/PrpD family
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01522 (5/5) Polysaccharide deacetylase
PF00596 (5/5) Class II Aldolase and Adducin N-terminal domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_groups_37713 306.94 +- 18.06 2 0 2 0 0.01 +- 0.01 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_15049 1387.76 +- 1182.51 7 0 2 0 0.02 +- 0.02 7 12

PF13535 (7/7) ATP-grasp domain
TIGR01263 (6/7) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (6/7) L-amino acid ligase C-terminal domain 2
PF14696 (6/7) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF05721 (6/7) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (6/7) Prephenate dehydrogenase
PF01613 (6/7) Flavin reductase like domain
PF01070 (6/7) FMN-dependent dehydrogenase
PF00903 (6/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (6/7) Luciferase-like monooxygenase
PF00155 (6/7) Aminotransferase class I and II
PF18130 (5/7) ATP-grasp N-terminal domain
precursor_groups_14066 854.07 +- 451.42 3 0 0 0 0.01 +- 0.00 3 4

PF00082 (3/3) Subtilase family
TIGR03930 (2/3) WXG100 family type VII secretion target
TIGR03921 (2/3) type VII secretion-associated serine protease mycosin
PF06013 (2/3) Proteins of 100 residues with WXG
precursor_groups_51305 16.08 +- 2.16 2 0 0 0 0.22 +- 0.37 2 6

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01694 (2/2) methylthioadenosine phosphorylase
PF09723 (2/2) Zinc ribbon domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01048 (2/2) Phosphorylase superfamily
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_21973 625.39 +- 132.43 5 0 0 0 0.01 +- 0.01 5 6

TIGR03930 (5/5) WXG100 family type VII secretion target
TIGR03921 (5/5) type VII secretion-associated serine protease mycosin
TIGR03919 (5/5) type VII secretion protein EccB
PF06013 (5/5) Proteins of 100 residues with WXG
PF05108 (5/5) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/5) Subtilase family
precursor_groups_53944 42.38 +- 0.62 2 0 0 0 0.09 +- 0.25 2 4

PF16945 (2/2) Putative lactococcus lactis phage r1t holin
PF08924 (2/2) Domain of unknown function (DUF1906)
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_3826 574.71 +- 631.09 10 0 10 0 0.12 +- 0.25 10 16

TIGR01733 (10/10) amino acid adenylation domain
TIGR01720 (10/10) non-ribosomal peptide synthase domain TIGR01720
TIGR01263 (10/10) 4-hydroxyphenylpyruvate dioxygenase
PF14696 (10/10) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF03621 (10/10) MbtH-like protein
PF02668 (10/10) Taurine catabolism dioxygenase TauD, TfdA family
PF02274 (10/10) Amidinotransferase
PF01070 (10/10) FMN-dependent dehydrogenase
PF00975 (10/10) Thioesterase domain
PF00903 (10/10) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF00155 (10/10) Aminotransferase class I and II
PF07690 (8/10) Major Facilitator Superfamily
precursor_groups_58221 645.32 +- 489.88 2 0 0 0 0.07 +- 0.21 2 11

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
precursor_groups_36155 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
precursor_groups_7062 54.96 +- 12.82 3 0 2 0 0.21 +- 0.26 3 11

PF07883 (3/3) Cupin domain
TIGR01409 (2/3) Tat (twin-arginine translocation) pathway signal sequence
PF13478 (2/3) XdhC Rossmann domain
PF03450 (2/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02627 (2/3) Carboxymuconolactone decarboxylase family
PF02625 (2/3) XdhC and CoxI family
PF01799 (2/3) [2Fe-2S] binding domain
PF01315 (2/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_72354 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_groups_10969 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_51037 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_62063 210.26 +- 3.86 2 0 0 0 0.04 +- 0.06 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_17587 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_groups_81851 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 8

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (2/2) GAF domain
PF12450 (2/2) von Willebrand factor
PF12034 (2/2) Domain of unknown function (DUF3520)
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03704 (2/2) Bacterial transcriptional activator domain
PF00092 (2/2) von Willebrand factor type A domain
precursor_groups_61719 1649.38 +- 170.62 2 0 1 0 0.01 +- 0.00 2 12

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF11706 (2/2) CGNR zinc finger
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07336 (2/2) Putative stress-induced transcription regulator
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF04854 (2/2) Protein of unknown function, DUF624
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00532 (2/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_82330 225.00 +- 165.00 2 0 0 2 0.03 +- 0.04 2 5

PF13671 (2/2) AAA domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF04055 (2/2) Radical SAM superfamily
PF01928 (2/2) CYTH domain
PF00293 (2/2) NUDIX domain
precursor_groups_14643 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_14647 25.95 +- 12.19 3 0 0 0 0.12 +- 0.07 3 3

PF01266 (3/3) FAD dependent oxidoreductase
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_groups_21713 270.68 +- 245.32 2 0 2 0 0.08 +- 0.13 2 7

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_13592 146.12 +- 113.88 2 0 1 0 0.14 +- 0.31 2 13

TIGR02103 (2/2) alpha-1,6-glucosidases, pullulanase-type
PF17967 (2/2) Pullulanase N2 domain
PF11852 (2/2) Domain of unknown function (DUF3372)
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (2/2) Alpha amylase, C-terminal all-beta domain
PF00128 (2/2) Alpha amylase, catalytic domain
TIGR01733 (1/2) amino acid adenylation domain
PF13847 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
precursor_groups_13190 299.34 +- 37.85 3 0 0 0 0.05 +- 0.05 3 12

PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08757 (3/3) CotH kinase protein
PF04138 (3/3) GtrA-like protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00672 (3/3) HAMP domain
PF00535 (3/3) Glycosyl transferase family 2
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF16316 (2/3) Domain of unknown function (DUF4956)
PF09359 (2/3) VTC domain
precursor_groups_20284 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_groups_63449 48.63 +- 6.77 2 0 0 0 0.19 +- 0.34 2 13

PF13641 (2/2) Glycosyltransferase like family 2
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12704 (2/2) MacB-like periplasmic core domain
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02687 (2/2) FtsX-like permease family
PF02127 (2/2) Aminopeptidase I zinc metalloprotease (M18)
PF00775 (2/2) Dioxygenase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_groups_70693 140.75 +- 119.25 2 0 0 0 0.05 +- 0.06 2 3

PF02018 (2/2) Carbohydrate binding domain
PF01872 (2/2) RibD C-terminal domain
PF00041 (2/2) Fibronectin type III domain
precursor_groups_85535 174.75 +- 18.75 2 0 0 0 0.01 +- 0.01 2 2

PF09335 (2/2) SNARE associated Golgi protein
PF08241 (2/2) Methyltransferase domain
precursor_groups_9673 88.97 +- 4.84 2 0 2 0 0.04 +- 0.05 2 6

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF01839 (2/2) FG-GAP repeat
precursor_groups_82334 720.96 +- 53.62 2 0 0 0 0.02 +- 0.00 2 11

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01425 (2/2) Amidase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR02713 (1/2) allophanate hydrolase
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF00455 (1/2) DeoR C terminal sensor domain
precursor_groups_373 63.68 +- 48.69 16 0 6 16 0.07 +- 0.12 16 2

PF04055 (16/16) Radical SAM superfamily
PF00583 (16/16) Acetyltransferase (GNAT) family
precursor_groups_20288 42.01 +- 6.74 2 0 0 0 0.10 +- 0.15 2 12

PF12682 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
TIGR01234 (1/2) ribulokinase
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13377 (1/2) Periplasmic binding protein-like domain
PF08022 (1/2) FAD-binding domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02424 (1/2) ApbE family
PF00970 (1/2) Oxidoreductase FAD-binding domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_1193 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like
precursor_groups_1192 94.31 +- 11.27 2 0 0 0 0.11 +- 0.22 2 26

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
TIGR02378 (2/2) nitrite reductase [NAD(P)H], small subunit
TIGR02374 (2/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (2/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (2/2) Rieske-like [2Fe-2S] domain
PF13520 (2/2) Amino acid permease
PF12840 (2/2) Helix-turn-helix domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF08327 (2/2) Activator of Hsp90 ATPase homolog 1-like protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07398 (2/2) MDMPI C-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03460 (2/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (2/2) Nitrite and sulphite reductase 4Fe-4S domain
PF00106 (2/2) short chain dehydrogenase
PF16640 (1/2) Bacterial Ig-like domain (group 3)
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07098 (1/2) Protein of unknown function (DUF1360)
PF06271 (1/2) RDD family
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01810 (1/2) LysE type translocator
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_32012 229.35 +- 53.17 4 0 0 0 0.02 +- 0.01 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF00455 (4/4) DeoR C terminal sensor domain
PF00359 (4/4) Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PF00027 (4/4) Cyclic nucleotide-binding domain
precursor_groups_70854 105.07 +- 2.91 2 0 1 0 0.16 +- 0.26 2 18

PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07729 (2/2) FCD domain
PF05544 (2/2) Proline racemase
PF05195 (2/2) Aminopeptidase P, N-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00557 (2/2) Metallopeptidase family M24
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13808 (1/2) DDE_Tnp_1-associated
precursor_groups_170 309.22 +- 390.64 18 0 2 0 0.07 +- 0.10 18 2

PF13561 (11/18) Enoyl-(Acyl carrier protein) reductase
PF07690 (9/18) Major Facilitator Superfamily
precursor_groups_58160 214.79 +- 47.95 2 0 0 0 0.08 +- 0.07 2 9

TIGR01234 (2/2) ribulokinase
PF13407 (2/2) Periplasmic binding protein domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_177 107.40 +- 82.05 8 0 2 1 0.07 +- 0.11 8 3

TIGR02434 (4/8) precorrin-6A synthase (deacetylating)
PF03745 (4/8) Domain of unknown function (DUF309)
PF00590 (4/8) Tetrapyrrole (Corrin/Porphyrin) Methylases
precursor_groups_13912 20.40 +- 12.10 2 0 0 0 0.15 +- 0.10 2 1

PF05685 (2/2) Putative restriction endonuclease
precursor_groups_79489 36.62 +- 5.24 2 0 0 0 0.20 +- 0.18 2 12

TIGR01234 (2/2) ribulokinase
PF13377 (2/2) Periplasmic binding protein-like domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF03473 (2/2) MOSC domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_2568 12.18 +- 4.03 18 0 0 0 0.18 +- 0.05 18 5

TIGR03802 (18/18) aspartate-alanine antiporter
TIGR03801 (18/18) aspartate 4-decarboxylase
PF06826 (18/18) Predicted Permease Membrane Region
PF02080 (18/18) TrkA-C domain
PF00155 (18/18) Aminotransferase class I and II
precursor_groups_21392 1192.54 +- 713.58 5 0 0 0 0.02 +- 0.02 5 6

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
precursor_groups_21393 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain
precursor_groups_5616 337.77 +- 33.50 2 0 2 0 0.21 +- 0.29 2 29

TIGR02246 (2/2) conserved hypothetical protein
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF12051 (2/2) Protein of unknown function (DUF3533)
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/2) Histidine kinase
PF04673 (2/2) Polyketide synthesis cyclase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00483 (2/2) Nucleotidyl transferase
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
precursor_groups_62118 155.26 +- 134.45 2 0 2 0 0.11 +- 0.28 2 15

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF05977 (1/2) Transmembrane secretion effector
PF03621 (1/2) MbtH-like protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
precursor_groups_46122 52.56 +- 3.75 3 0 0 0 0.08 +- 0.08 3 5

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF10990 (3/3) Protein of unknown function (DUF2809)
PF07681 (3/3) DoxX
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_2562 72.50 +- 7.50 2 0 0 0 0.03 +- 0.03 2 4

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF12840 (2/2) Helix-turn-helix domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_1022 20.61 +- 16.38 9 0 0 0 0.20 +- 0.36 9 6

PF12806 (9/9) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (9/9) Acyl-CoA dehydrogenase N terminal
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF00775 (9/9) Dioxygenase
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF13641 (8/9) Glycosyltransferase like family 2
precursor_groups_68725 58.29 +- 19.11 2 0 0 2 0.17 +- 0.25 2 5

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01425 (2/2) Amidase
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_197 66.29 +- 60.85 9 0 3 0 0.09 +- 0.13 9 1

PF07690 (5/9) Major Facilitator Superfamily
precursor_groups_195 236.10 +- 302.19 7 0 3 1 0.09 +- 0.18 7

No common domains found
precursor_groups_26091 34.16 +- 4.43 2 0 0 0 0.15 +- 0.15 2 8

PF13796 (2/2) Putative sensor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07730 (2/2) Histidine kinase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_192 120.14 +- 113.24 33 0 29 1 0.10 +- 0.19 33 4

PF07690 (33/33) Major Facilitator Superfamily
PF00484 (29/33) Carbonic anhydrase
PF00916 (26/33) Sulfate permease family
PF03756 (25/33) A-factor biosynthesis hotdog domain
precursor_groups_65723 74.02 +- 1.46 2 0 1 0 0.04 +- 0.04 2 5

TIGR04538 (2/2) cytochrome P450, cyclodipeptide synthase-associated
PF13191 (2/2) AAA ATPase domain
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00067 (2/2) Cytochrome P450
precursor_groups_45592 1258.84 +- 54.84 2 0 2 0 0.02 +- 0.05 2 9

TIGR00830 (2/2) PTS system, glucose subfamily, IIA component
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00069 (2/2) Protein kinase domain
precursor_groups_23986 673.65 +- 236.08 4 0 0 0 0.02 +- 0.05 4 16

PF18448 (4/4) Carbohydrate binding domain
PF17851 (4/4) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (4/4) Domain of unknown function(DUF4981)
PF14310 (4/4) Fibronectin type III-like domain
PF04616 (4/4) Glycosyl hydrolases family 43
PF03442 (4/4) Carbohydrate binding domain X2
PF03422 (4/4) Carbohydrate binding module (family 6)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (4/4) Alpha-L-fucosidase
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF15902 (3/4) Sortilin, neurotensin receptor 3,
PF14200 (3/4) Ricin-type beta-trefoil lectin domain-like
precursor_groups_19605 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_33127 51.16 +- 8.06 3 0 3 0 0.17 +- 0.37 3 16

TIGR01490 (3/3) HAD hydrolase, family IB
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF12680 (3/3) SnoaL-like domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF03756 (3/3) A-factor biosynthesis hotdog domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01494 (3/3) FAD binding domain
PF01144 (3/3) Coenzyme A transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_46833 727.66 +- 157.71 3 0 3 3 0.02 +- 0.02 3 15

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01733 (3/3) amino acid adenylation domain
TIGR00778 (3/3) alkylhydroperoxidase AhpD family core domain
PF13454 (3/3) FAD-NAD(P)-binding
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02896 (3/3) PEP-utilising enzyme, TIM barrel domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_groups_36442 226.51 +- 44.39 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_groups_69032 208.94 +- 79.94 2 0 2 0 0.02 +- 0.04 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF14518 (2/2) Iron-containing redox enzyme
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF04820 (2/2) Tryptophan halogenase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_513 198.12 +- 240.41 43 0 9 43 0.07 +- 0.12 43 10

TIGR03859 (43/43) coenzyme PQQ biosynthesis protein PqqD
TIGR02109 (43/43) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (43/43) Iron-sulfur cluster-binding domain
PF05402 (43/43) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (43/43) Radical SAM superfamily
TIGR02111 (42/43) coenzyme PQQ biosynthesis protein C
PF03070 (42/43) TENA/THI-4/PQQC family
PF12706 (39/43) Beta-lactamase superfamily domain
TIGR02107 (36/43) coenzyme PQQ precursor peptide PqqA
PF07995 (35/43) Glucose / Sorbosone dehydrogenase
precursor_groups_512 251.83 +- 229.06 10 0 1 0 0.04 +- 0.05 10 2

PF08007 (10/10) Cupin superfamily protein
PF00248 (10/10) Aldo/keto reductase family
precursor_groups_32701 120.40 +- 34.40 2 0 0 2 0.02 +- 0.02 2 5

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF03995 (2/2) Peptidase inhibitor family I36
PF00733 (2/2) Asparagine synthase
PF00067 (2/2) Cytochrome P450
precursor_groups_33129 23.98 +- 1.54 3 0 0 0 0.19 +- 0.36 3 9

TIGR00485 (3/3) translation elongation factor Tu
PF13828 (3/3) Domain of unknown function (DUF4190)
PF09913 (3/3) Predicted membrane protein (DUF2142)
PF08044 (3/3) Domain of unknown function (DUF1707)
PF03144 (3/3) Elongation factor Tu domain 2
PF03143 (3/3) Elongation factor Tu C-terminal domain
PF00009 (3/3) Elongation factor Tu GTP binding domain
PF04138 (2/3) GtrA-like protein
PF00535 (2/3) Glycosyl transferase family 2
precursor_groups_4749 302.33 +- 44.33 2 0 0 0 0.01 +- 0.01 2 7

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13499 (1/2) EF-hand domain pair
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02378 (1/2) Phosphotransferase system, EIIC
PF01828 (1/2) Peptidase A4 family
PF00367 (1/2) phosphotransferase system, EIIB
PF00089 (1/2) Trypsin
precursor_groups_430 310.09 +- 269.71 4 0 0 0 0.03 +- 0.04 4 8

TIGR01525 (2/4) heavy metal translocating P-type ATPase
PF08007 (2/4) Cupin superfamily protein
PF07371 (2/4) Protein of unknown function (DUF1490)
PF01297 (2/4) Zinc-uptake complex component A periplasmic
PF00950 (2/4) ABC 3 transport family
PF00702 (2/4) haloacid dehalogenase-like hydrolase
PF00122 (2/4) E1-E2 ATPase
PF00005 (2/4) ABC transporter
precursor_groups_24508 78.19 +- 0.44 2 0 0 0 0.10 +- 0.24 2 10

PF17668 (2/2) Acetyltransferase (GNAT) domain
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13530 (2/2) Sterol carrier protein domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12821 (2/2) Threonine/Serine exporter, ThrE
PF09335 (2/2) SNARE associated Golgi protein
PF06738 (2/2) Putative threonine/serine exporter
PF00877 (2/2) NlpC/P60 family
PF00183 (2/2) Hsp90 protein
precursor_groups_17111 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18014 (2/2) Acetyltransferase (GNAT) domain
PF03777 (2/2) ChpA-C
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_18812 97.37 +- 34.76 4 0 0 0 0.17 +- 0.32 4 10

TIGR03177 (4/4) Flp pilus assembly protein CpaB
PF16976 (4/4) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/4) AAA domain
PF13400 (4/4) Putative Flp pilus-assembly TadE/G-like
PF07811 (4/4) TadE-like protein
PF00691 (4/4) OmpA family
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
precursor_groups_59785 350.75 +- 107.92 2 0 0 0 0.01 +- 0.01 2 8

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_4744 828.38 +- 731.62 2 0 0 0 0.05 +- 0.06 2 17

PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR02100 (1/2) glycogen debranching enzyme GlgX
TIGR01186 (1/2) glycine betaine/L-proline transport ATP binding subunit
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13183 (1/2) 4Fe-4S dicluster domain
PF09339 (1/2) IclR helix-turn-helix domain
PF04069 (1/2) Substrate binding domain of ABC-type glycine betaine transport system
PF02922 (1/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02754 (1/2) Cysteine-rich domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (1/2) Bacterial transcriptional regulator
PF01565 (1/2) FAD binding domain
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00480 (1/2) ROK family
PF00005 (1/2) ABC transporter
precursor_groups_67341 447.87 +- 22.41 2 0 0 0 0.04 +- 0.02 2 16

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_47838 57.63 +- 1.91 2 0 2 0 0.03 +- 0.03 2 2

PF13649 (2/2) Methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_2984 86.77 +- 56.59 26 0 0 0 0.03 +- 0.03 26 2

PF01408 (26/26) Oxidoreductase family, NAD-binding Rossmann fold
PF00232 (26/26) Glycosyl hydrolase family 1
precursor_groups_46448 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_39890 343.01 +- 173.37 3 0 3 0 0.07 +- 0.21 3 17

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13578 (3/3) Methyltransferase domain
PF13191 (3/3) AAA ATPase domain
PF05199 (3/3) GMC oxidoreductase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03704 (3/3) Bacterial transcriptional activator domain
PF01266 (3/3) FAD dependent oxidoreductase
PF01061 (3/3) ABC-2 type transporter
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00732 (3/3) GMC oxidoreductase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/3) Acyl transferase domain
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/3) ABC transporter
precursor_groups_2989 87.05 +- 60.96 10 0 10 0 0.04 +- 0.04 10 9

PF16197 (10/10) Ketoacyl-synthetase C-terminal extension
PF14765 (10/10) Polyketide synthase dehydratase
PF08659 (10/10) KR domain
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF00698 (10/10) Acyl transferase domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00107 (10/10) Zinc-binding dehydrogenase
PF08240 (9/10) Alcohol dehydrogenase GroES-like domain
precursor_groups_84495 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_groups_84497 4695.60 +- 0.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12698 (2/2) ABC-2 family transporter protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_groups_39710 774.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

TIGR01473 (2/2) protoheme IX farnesyltransferase
TIGR01413 (2/2) Dyp-type peroxidase family
PF07690 (2/2) Major Facilitator Superfamily
PF04261 (2/2) Dyp-type peroxidase family
PF01040 (2/2) UbiA prenyltransferase family
precursor_groups_2742 157.42 +- 93.51 5 0 0 0 0.04 +- 0.08 5 5

PF06628 (5/5) Catalase-related immune-responsive
PF01475 (5/5) Ferric uptake regulator family
PF00248 (5/5) Aldo/keto reductase family
PF00199 (5/5) Catalase
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
precursor_groups_65610 24.38 +- 8.12 2 0 0 0 0.12 +- 0.08 2 4

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/2) Alpha galactosidase A
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_groups_13130 677.70 +- 428.02 2 0 2 0 0.02 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_47723 324.11 +- 14.51 2 0 2 0 0.02 +- 0.03 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13610 (2/2) DDE domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF02554 (2/2) Carbon starvation protein CstA
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
precursor_groups_39552 29.47 +- 3.47 2 0 0 0 0.10 +- 0.09 2 4

TIGR01412 (2/2) Tat-translocated enzyme
PF09375 (2/2) Imelysin
PF04261 (2/2) Dyp-type peroxidase family
PF04185 (2/2) Phosphoesterase family
precursor_groups_14797 36.92 +- 14.90 5 0 0 0 0.06 +- 0.08 5 3

PF09586 (5/5) Bacterial membrane protein YfhO
PF04138 (5/5) GtrA-like protein
PF00535 (5/5) Glycosyl transferase family 2
precursor_groups_209 114.93 +- 57.15 4 0 1 0 0.04 +- 0.03 4 3

PF13673 (4/4) Acetyltransferase (GNAT) domain
PF07702 (4/4) UTRA domain
PF00392 (3/4) Bacterial regulatory proteins, gntR family
precursor_groups_208 112.45 +- 160.34 4 0 1 0 0.13 +- 0.23 4 3

PF00355 (2/4) Rieske [2Fe-2S] domain
PF00175 (2/4) Oxidoreductase NAD-binding domain
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_9169 21.79 +- 4.26 5 0 0 0 0.09 +- 0.12 5 3

PF14016 (5/5) Protein of unknown function (DUF4232)
PF10604 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF07859 (5/5) alpha/beta hydrolase fold
precursor_groups_28197 561.74 +- 523.38 2 0 2 0 0.11 +- 0.24 2 17

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08892 (2/2) YqcI/YcgG family
PF03621 (2/2) MbtH-like protein
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF01863 (1/2) Protein of unknown function DUF45
precursor_groups_26 99.36 +- 86.34 150 1 59 3 0.16 +- 0.21 149 6

PF00005 (89/150) ABC transporter
PF03412 (87/150) Peptidase C39 family
PF00664 (87/150) ABC transporter transmembrane region
TIGR03796 (86/150) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03797 (85/150) NHLM bacteriocin system ABC transporter, ATP-binding protein
PF13437 (81/150) HlyD family secretion protein
precursor_groups_60022 222.57 +- 67.66 2 0 0 0 0.07 +- 0.04 2 12

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF04952 (1/2) Succinylglutamate desuccinylase / Aspartoacylase family
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III
precursor_groups_22610 71.51 +- 26.10 5 0 5 5 0.07 +- 0.04 5 2

PF04055 (5/5) Radical SAM superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_groups_2188 209.10 +- 104.67 6 0 0 0 0.09 +- 0.18 6 4

PF00171 (5/6) Aldehyde dehydrogenase family
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00067 (3/6) Cytochrome P450
PF00005 (3/6) ABC transporter
precursor_groups_81042 636.32 +- 221.68 2 0 0 0 0.02 +- 0.03 2 3

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_55307 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V
precursor_groups_47051 284.94 +- 150.47 3 0 3 0 0.04 +- 0.04 3 11

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
TIGR00414 (3/3) serine--tRNA ligase
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03972 (3/3) MmgE/PrpD family
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00587 (3/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (3/3) Phosphopantetheine attachment site
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_67751 81.99 +- 26.34 2 0 2 0 0.14 +- 0.19 2 8

PF06889 (2/2) Protein of unknown function (DUF1266)
PF03795 (2/2) YCII-related domain
PF00248 (2/2) Aldo/keto reductase family
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00005 (1/2) ABC transporter
precursor_groups_2182 238.88 +- 175.64 2 0 0 0 0.13 +- 0.27 2 21

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF08241 (2/2) Methyltransferase domain
PF07811 (2/2) TadE-like protein
PF01638 (2/2) HxlR-like helix-turn-helix
PF01580 (2/2) FtsK/SpoIIIE family
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03696 (1/2) RHS repeat-associated core domain
PF15575 (1/2) Immunity protein 49
PF13614 (1/2) AAA domain
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF10609 (1/2) NUBPL iron-transfer P-loop NTPase
PF03534 (1/2) Salmonella virulence plasmid 65kDa B protein
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_56078 58.18 +- 2.13 2 0 0 0 0.15 +- 0.08 2 8

PF07969 (2/2) Amidohydrolase family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF01047 (2/2) MarR family
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_35360 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF17912 (2/2) MalK OB fold domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12899 (2/2) Alkaline and neutral invertase
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_24878 33.15 +- 2.48 3 0 0 0 0.12 +- 0.07 3 7

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_18822 307.75 +- 125.21 4 0 0 0 0.01 +- 0.00 4 2

PF00089 (4/4) Trypsin
PF13517 (3/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
precursor_groups_56564 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_72901 86.33 +- 0.33 2 0 0 0 0.02 +- 0.02 2 2

PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_77624 147.49 +- 19.43 2 0 0 2 0.17 +- 0.22 2 20

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (2/2) formate acetyltransferase
TIGR00886 (2/2) nitrite transporter
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01228 (2/2) Glycine radical
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
TIGR02374 (1/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (1/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (1/2) Rieske-like [2Fe-2S] domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF03460 (1/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (1/2) Nitrite and sulphite reductase 4Fe-4S domain
precursor_groups_45811 187.64 +- 18.76 2 0 0 0 0.05 +- 0.04 2 8

PF14016 (2/2) Protein of unknown function (DUF4232)
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (2/2) Alpha mannosidase middle domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_25675 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_21705 611.83 +- 229.98 5 0 0 0 0.01 +- 0.01 5 11

TIGR01490 (5/5) HAD hydrolase, family IB
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF05655 (4/5) Pseudomonas avirulence D protein (AvrD)
PF01648 (4/5) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/5) Thioesterase domain
PF00550 (4/5) Phosphopantetheine attachment site
precursor_groups_28285 416.77 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04909 (2/2) Amidohydrolase
PF00501 (2/2) AMP-binding enzyme
precursor_groups_16774 192.40 +- 85.37 6 0 0 0 0.02 +- 0.03 6 7

TIGR03930 (6/6) WXG100 family type VII secretion target
TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF06013 (6/6) Proteins of 100 residues with WXG
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/6) YbaB/EbfC DNA-binding family
precursor_groups_2343 222.48 +- 53.07 3 0 0 0 0.01 +- 0.01 3 3

PF04134 (3/3) Protein of unknown function, DUF393
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13560 (2/3) Helix-turn-helix domain
precursor_groups_25479 31.27 +- 6.97 2 0 2 0 0.13 +- 0.25 2 8

PF17871 (2/2) AAA lid domain
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF01546 (2/2) Peptidase family M20/M25/M40
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_24472 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 2

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00069 (2/2) Protein kinase domain
precursor_groups_15997 23.17 +- 6.67 3 0 3 0 0.10 +- 0.11 3 7

PF13407 (3/3) Periplasmic binding protein domain
PF08376 (3/3) Nitrate and nitrite sensing
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF00672 (3/3) HAMP domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_71489 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_1378 451.50 +- 64.50 2 0 2 0 0.01 +- 0.00 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
precursor_groups_31656 201.84 +- 49.19 3 0 0 0 0.12 +- 0.20 3 23

TIGR04037 (3/3) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (3/3) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF17853 (3/3) GGDEF-like domain
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14525 (3/3) AraC-binding-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13191 (3/3) AAA ATPase domain
PF12833 (3/3) Helix-turn-helix domain
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07969 (3/3) Amidohydrolase family
PF07859 (3/3) alpha/beta hydrolase fold
PF07681 (3/3) DoxX
PF03358 (3/3) NADPH-dependent FMN reductase
PF02852 (3/3) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01184 (3/3) GPR1/FUN34/yaaH family
PF00857 (3/3) Isochorismatase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00210 (3/3) Ferritin-like domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_86564 185.29 +- 74.71 2 0 2 0 0.01 +- 0.01 2 3

PF02195 (2/2) ParB-like nuclease domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
precursor_groups_11429 63.39 +- 17.86 2 0 0 0 0.04 +- 0.02 2 5

PF13404 (2/2) AsnC-type helix-turn-helix domain
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_groups_55789 150.11 +- 37.53 2 0 0 0 0.06 +- 0.05 2 6

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00313 (2/2) 'Cold-shock' DNA-binding domain
precursor_groups_19395 208.21 +- 217.64 3 0 0 0 0.05 +- 0.06 3 4

PF13439 (3/3) Glycosyltransferase Family 4
PF06737 (3/3) Transglycosylase-like domain
PF01476 (3/3) LysM domain
PF00534 (3/3) Glycosyl transferases group 1
precursor_groups_58968 137.33 +- 82.04 2 0 2 0 0.04 +- 0.05 2 12

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03936 (2/2) Terpene synthase family, metal binding domain
PF00348 (2/2) Polyprenyl synthetase
PF00067 (2/2) Cytochrome P450
TIGR01534 (1/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02800 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00106 (1/2) short chain dehydrogenase
PF00044 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_39856 89.33 +- 31.49 3 0 0 0 0.19 +- 0.32 3 10

PF18844 (3/3) Bacterial archaeo-eukaryotic release factor family 2
PF13847 (3/3) Methyltransferase domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF11387 (3/3) Protein of unknown function (DUF2795)
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF01569 (3/3) PAP2 superfamily
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_28971 216.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 2

PF06013 (2/2) Proteins of 100 residues with WXG
PF02254 (2/2) TrkA-N domain
precursor_groups_17856 17.54 +- 8.83 4 0 4 0 0.18 +- 0.25 4 14

PF12740 (4/4) Chlorophyllase enzyme
PF12697 (4/4) Alpha/beta hydrolase family
PF06386 (4/4) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (4/4) Gas vesicle synthesis protein GvpO
PF05121 (4/4) Gas vesicle protein K
PF05120 (4/4) Gas vesicle protein G
PF00741 (4/4) Gas vesicle protein
PF00561 (4/4) alpha/beta hydrolase fold
TIGR03086 (2/4) TIGR03086 family protein
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF11716 (2/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11611 (2/4) Domain of unknown function (DUF4352)
PF07690 (2/4) Major Facilitator Superfamily
PF00730 (2/4) HhH-GPD superfamily base excision DNA repair protein
precursor_groups_73414 199.03 +- 100.12 2 0 0 0 0.17 +- 0.30 2 18

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF13518 (1/2) Helix-turn-helix domain
PF13401 (1/2) AAA domain
PF09299 (1/2) Mu transposase, C-terminal
PF08722 (1/2) TnsA endonuclease N terminal
PF06527 (1/2) TniQ
PF00665 (1/2) Integrase core domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_38284 154.57 +- 48.14 2 0 2 0 0.08 +- 0.18 2 15

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF03621 (2/2) MbtH-like protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_74379 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_25018 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450
precursor_groups_38447 20.19 +- 4.93 3 0 0 0 0.17 +- 0.34 3 8

TIGR00762 (3/3) EDD domain protein, DegV family
TIGR00360 (3/3) ComEC/Rec2-related protein
PF12840 (3/3) Helix-turn-helix domain
PF07690 (3/3) Major Facilitator Superfamily
PF03772 (3/3) Competence protein
PF02645 (3/3) Uncharacterised protein, DegV family COG1307
PF00797 (3/3) N-acetyltransferase
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_groups_45055 337.28 +- 59.65 2 0 1 0 0.06 +- 0.08 2 9

PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
TIGR03544 (1/2) DivIVA domain
TIGR01297 (1/2) cation diffusion facilitator family transporter
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF05103 (1/2) DivIVA protein
PF04234 (1/2) CopC domain
PF01545 (1/2) Cation efflux family
PF00581 (1/2) Rhodanese-like domain
precursor_groups_6246 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
precursor_groups_12835 185.41 +- 246.26 7 0 0 0 0.04 +- 0.05 7 2

TIGR03930 (7/7) WXG100 family type VII secretion target
PF06013 (7/7) Proteins of 100 residues with WXG
precursor_groups_690 3950.85 +- 3927.37 2 0 1 1 0.05 +- 0.19 2 22

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02116 (1/2) addiction module toxin, Txe/YoeB family
TIGR01552 (1/2) prevent-host-death family protein
PF18478 (1/2) PIN like domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF12419 (1/2) SNF2 Helicase protein
PF07969 (1/2) Amidohydrolase family
PF06769 (1/2) YoeB-like toxin of bacterial type II toxin-antitoxin system
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04434 (1/2) SWIM zinc finger
PF04255 (1/2) Protein of unknown function (DUF433)
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02604 (1/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01966 (1/2) HD domain
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00271 (1/2) Helicase conserved C-terminal domain
PF00176 (1/2) SNF2 family N-terminal domain
PF00005 (1/2) ABC transporter
precursor_groups_7765 1072.50 +- 214.50 2 0 2 0 0.01 +- 0.01 2 11

PF16861 (2/2) Carbamoyltransferase C-terminus
PF13560 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_2334 256.55 +- 218.63 33 0 0 0 0.03 +- 0.03 33 10

TIGR03930 (33/33) WXG100 family type VII secretion target
TIGR03919 (33/33) type VII secretion protein EccB
PF06013 (33/33) Proteins of 100 residues with WXG
PF05108 (33/33) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (32/33) type VII secretion integral membrane protein EccD
PF08817 (31/33) WXG100 protein secretion system (Wss), protein YukD
PF02575 (31/33) YbaB/EbfC DNA-binding family
PF15644 (23/33) Papain fold toxin 1, glutamine deamidase
PF07179 (22/33) SseB protein N-terminal domain
PF00652 (22/33) Ricin-type beta-trefoil lectin domain
precursor_groups_55899 55.24 +- 28.63 2 0 0 0 0.12 +- 0.21 2 11

PF09861 (2/2) Lactate racemase N-terminal domain
PF07729 (2/2) FCD domain
PF04909 (2/2) Amidohydrolase
PF01969 (2/2) Protein of unknown function DUF111
PF00731 (2/2) AIR carboxylase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
TIGR00299 (1/2) TIGR00299 family protein
TIGR00268 (1/2) TIGR00268 family protein
PF02540 (1/2) NAD synthase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
precursor_groups_67622 62.30 +- 4.94 2 0 0 0 0.15 +- 0.15 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_groups_68106 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 10

TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13238 (2/2) AAA domain
PF04055 (2/2) Radical SAM superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_60110 36.01 +- 8.86 2 0 2 0 0.06 +- 0.08 2 3

PF14019 (2/2) Protein of unknown function (DUF4235)
PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_groups_16236 47.65 +- 40.64 6 0 4 0 0.15 +- 0.29 6 13

PF13977 (6/6) BetI-type transcriptional repressor, C-terminal
PF13607 (6/6) Succinyl-CoA ligase like flavodoxin domain
PF13549 (6/6) ATP-grasp domain
PF13459 (6/6) 4Fe-4S single cluster domain
PF13380 (6/6) CoA binding domain
PF10589 (6/6) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (6/6) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
precursor_groups_36166 422.22 +- 203.82 3 0 3 0 0.03 +- 0.03 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF13350 (3/3) Tyrosine phosphatase family
PF02543 (3/3) Carbamoyltransferase N-terminus
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_groups_6887 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_6888 171.70 +- 129.89 6 0 0 0 0.07 +- 0.15 6 3

PF08445 (6/6) FR47-like protein
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00005 (3/6) ABC transporter
precursor_groups_83681 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase
precursor_groups_67381 304.77 +- 44.77 2 0 0 0 0.02 +- 0.01 2 6

PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01935 (2/2) Helicase HerA, central domain
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_groups_34387 259.33 +- 0.94 3 0 0 0 0.01 +- 0.00 3 3

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00550 (3/3) Phosphopantetheine attachment site
precursor_groups_74203 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_55256 109.67 +- 50.19 2 0 0 0 0.12 +- 0.15 2 16

PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (1/2) FCD domain
PF04909 (1/2) Amidohydrolase
PF01081 (1/2) KDPG and KHG aldolase
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_12066 1002.86 +- 0.00 2 0 2 0 0.02 +- 0.01 2 11

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF03466 (2/2) LysR substrate binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00664 (2/2) ABC transporter transmembrane region
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_6405 17.34 +- 2.16 2 0 0 0 0.16 +- 0.13 2 4

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF08282 (1/2) haloacid dehalogenase-like hydrolase
precursor_groups_54415 183.95 +- 117.50 2 0 0 0 0.09 +- 0.21 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13515 (2/2) Fusaric acid resistance protein-like
PF13454 (2/2) FAD-NAD(P)-binding
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00206 (2/2) Lyase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_54414 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_3163 245.26 +- 121.26 3 0 0 0 0.07 +- 0.20 3 3

PF02782 (2/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_12733 114.15 +- 7.92 2 0 2 0 0.10 +- 0.09 2 16

TIGR01662 (2/2) HAD hydrolase, family IIIA
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13580 (2/2) SIS domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13242 (2/2) HAD-hyrolase-like
PF12028 (2/2) Protein of unknown function (DUF3515)
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01467 (2/2) Cytidylyltransferase-like
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR02199 (1/2) bifunctional protein RfaE, domain II
TIGR00125 (1/2) cytidyltransferase-like domain
precursor_groups_1870 81.90 +- 63.05 29 0 11 29 0.13 +- 0.16 29 5

TIGR03882 (29/29) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (29/29) thiazole/oxazole-forming peptide maturase, SagD family component
PF03704 (29/29) Bacterial transcriptional activator domain
PF02624 (29/29) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (28/29) Transcriptional regulatory protein, C terminal
precursor_groups_70218 15.80 +- 3.70 2 0 0 0 0.21 +- 0.21 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04341 (2/2) Protein of unknown function, DUF485
PF04029 (2/2) 2-phosphosulpholactate phosphatase
PF00474 (2/2) Sodium:solute symporter family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF18029 (1/2) Glyoxalase-like domain
precursor_groups_26113 129.12 +- 80.38 3 0 0 0 0.04 +- 0.05 3 4

PF08223 (3/3) PaaX-like protein C-terminal domain
PF07848 (3/3) PaaX-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF00534 (3/3) Glycosyl transferases group 1
precursor_groups_80587 22.87 +- 1.20 2 0 0 0 0.20 +- 0.17 2 23

TIGR03346 (2/2) ATP-dependent chaperone protein ClpB
TIGR02350 (2/2) chaperone protein DnaK
TIGR01068 (2/2) thioredoxin
PF17871 (2/2) AAA lid domain
PF13591 (2/2) MerR HTH family regulatory protein
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF02148 (2/2) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (2/2) DnaJ C terminal domain
PF01025 (2/2) GrpE
PF00226 (2/2) DnaJ domain
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00012 (2/2) Hsp70 protein
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
TIGR00630 (1/2) excinuclease ABC subunit A
PF17755 (1/2) UvrA DNA-binding domain
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
PF01411 (1/2) tRNA synthetases class II (A)
PF00005 (1/2) ABC transporter
precursor_groups_31428 133.50 +- 84.85 3 0 0 0 0.08 +- 0.20 3 4

PF07690 (3/3) Major Facilitator Superfamily
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_7448 764.63 +- 408.17 4 0 4 4 0.04 +- 0.17 4 8

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF13520 (4/4) Amino acid permease
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
precursor_groups_1878 217.04 +- 228.81 5 0 0 0 0.07 +- 0.15 5 5

PF07690 (5/5) Major Facilitator Superfamily
PF03713 (5/5) Domain of unknown function (DUF305)
PF14342 (3/5) Domain of unknown function (DUF4396)
PF03860 (3/5) Domain of Unknown Function (DUF326)
PF00291 (3/5) Pyridoxal-phosphate dependent enzyme
precursor_groups_61379 554.14 +- 219.86 2 0 2 0 0.02 +- 0.02 2 6

PF16861 (2/2) Carbamoyltransferase C-terminus
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00005 (2/2) ABC transporter
precursor_groups_69347 810.28 +- 423.28 2 0 0 1 0.04 +- 0.15 2 15

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01478 (2/2) Type IV leader peptidase family
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
TIGR00702 (1/2) YcaO-type kinase domain
PF13649 (1/2) Methyltransferase domain
PF07812 (1/2) TfuA-like protein
PF07479 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01210 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
PF00482 (1/2) Type II secretion system (T2SS), protein F
precursor_groups_63906 236.46 +- 153.54 2 0 2 2 0.02 +- 0.03 2 5

TIGR02438 (2/2) catechol 1,2-dioxygenase
PF04444 (2/2) Catechol dioxygenase N terminus
PF01494 (2/2) FAD binding domain
PF00775 (2/2) Dioxygenase
PF00733 (2/2) Asparagine synthase
precursor_groups_34143 45.54 +- 18.30 3 0 0 0 0.10 +- 0.12 3 7

PF04016 (3/3) Putative heavy-metal chelation
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00288 (3/3) GHMP kinases N terminal domain
PF00005 (3/3) ABC transporter
PF05175 (2/3) Methyltransferase small domain
precursor_groups_46484 994.22 +- 94.22 2 0 0 0 0.02 +- 0.02 2 14

TIGR04416 (2/2) group II intron reverse transcriptase/maturase
PF14759 (2/2) Reductase C-terminal
PF08388 (2/2) Group II intron, maturase-specific domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04213 (2/2) Htaa
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00665 (2/2) Integrase core domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00248 (2/2) Aldo/keto reductase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
PF00067 (2/2) Cytochrome P450
precursor_groups_78736 62.24 +- 15.92 2 0 0 0 0.12 +- 0.17 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_groups_32830 262.22 +- 21.70 3 0 3 3 0.14 +- 0.15 3 18

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
TIGR01525 (3/3) heavy metal translocating P-type ATPase
PF13537 (3/3) Glutamine amidotransferase domain
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF06197 (3/3) Protein of unknown function (DUF998)
PF05141 (3/3) Pyoverdine/dityrosine biosynthesis protein
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00733 (3/3) Asparagine synthase
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
precursor_groups_32024 125.03 +- 36.02 3 0 3 0 0.14 +- 0.30 3 21

TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF14765 (2/3) Polyketide synthase dehydratase
PF08990 (2/3) Erythronolide synthase docking
PF08659 (2/3) KR domain
PF08044 (2/3) Domain of unknown function (DUF1707)
precursor_groups_77083 496.76 +- 283.24 2 0 2 0 0.02 +- 0.01 2 15

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_groups_69987 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_59887 70.34 +- 2.22 2 0 0 0 0.23 +- 0.10 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_26733 37.78 +- 1.22 2 0 0 0 0.08 +- 0.06 2 4

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF04616 (2/2) Glycosyl hydrolases family 43
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_66214 144.28 +- 34.15 2 0 0 0 0.07 +- 0.08 2 8

PF13377 (2/2) Periplasmic binding protein-like domain
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_35120 653.79 +- 174.26 3 0 0 0 0.01 +- 0.00 3 9

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF12146 (3/3) Serine aminopeptidase, S33
PF03795 (3/3) YCII-related domain
PF03321 (3/3) GH3 auxin-responsive promoter
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_6662 147.87 +- 24.54 4 0 0 0 0.03 +- 0.04 4 10

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (4/4) benzoate transporter
PF17920 (4/4) Tetracyclin repressor-like, C-terminal domain
PF13454 (4/4) FAD-NAD(P)-binding
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_26609 98.56 +- 110.67 4 0 0 0 0.14 +- 0.30 4 8

PF13183 (4/4) 4Fe-4S dicluster domain
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01565 (4/4) FAD binding domain
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
precursor_groups_6666 29.99 +- 4.41 4 0 0 0 0.16 +- 0.32 4 10

PF17042 (4/4) Nucleotide-binding C-terminal domain
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
TIGR01935 (3/4) RraA family
PF04332 (3/4) Protein of unknown function (DUF475)
PF03737 (3/4) Aldolase/RraA
precursor_groups_11194 227.50 +- 32.50 2 0 2 0 0.01 +- 0.00 2 2

PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
precursor_groups_6668 89.38 +- 40.62 2 0 0 0 0.03 +- 0.01 2 4

PF13466 (2/2) STAS domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02607 (2/2) B12 binding domain
PF02310 (2/2) B12 binding domain
precursor_groups_12881 73.89 +- 8.30 2 0 0 0 0.12 +- 0.25 2 10

PF07811 (2/2) TadE-like protein
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03177 (1/2) Flp pilus assembly protein CpaB
PF16976 (1/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (1/2) AAA domain
PF08241 (1/2) Methyltransferase domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF00005 (1/2) ABC transporter
precursor_groups_12882 304.96 +- 212.94 8 0 0 0 0.04 +- 0.04 8 8

TIGR01821 (8/8) 5-aminolevulinic acid synthase
PF07690 (8/8) Major Facilitator Superfamily
PF06224 (8/8) Winged helix DNA-binding domain
PF03466 (8/8) LysR substrate binding domain
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00155 (8/8) Aminotransferase class I and II
PF00126 (8/8) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_29959 1134.75 +- 490.59 4 0 0 0 0.01 +- 0.01 4 9

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF04686 (4/4) Streptomyces sporulation and cell division protein, SsgA
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_groups_69507 324.00 +- 66.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00491 (2/2) Arginase family
PF01636 (1/2) Phosphotransferase enzyme family
precursor_groups_11352 175.15 +- 104.09 7 0 7 0 0.03 +- 0.03 7 8

TIGR01733 (7/7) amino acid adenylation domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF01494 (7/7) FAD binding domain
PF00975 (7/7) Thioesterase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00106 (7/7) short chain dehydrogenase
precursor_groups_4804 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix
precursor_groups_13697 173.68 +- 35.26 5 0 1 0 0.12 +- 0.17 5 19

PF17853 (5/5) GGDEF-like domain
PF14542 (5/5) GCN5-related N-acetyl-transferase
PF14525 (5/5) AraC-binding-like domain
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13191 (5/5) AAA ATPase domain
PF12833 (5/5) Helix-turn-helix domain
PF12697 (5/5) Alpha/beta hydrolase family
PF07969 (5/5) Amidohydrolase family
PF07859 (5/5) alpha/beta hydrolase fold
PF07681 (5/5) DoxX
PF01547 (5/5) Bacterial extracellular solute-binding protein
PF01184 (5/5) GPR1/FUN34/yaaH family
PF00857 (5/5) Isochorismatase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00210 (5/5) Ferritin-like domain
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF07992 (3/5) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (3/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
precursor_groups_8732 53.79 +- 13.26 5 0 5 0 0.18 +- 0.19 5 24

TIGR00073 (5/5) hydrogenase accessory protein HypB
TIGR00072 (5/5) hydrogenase maturation protease
PF14720 (5/5) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (5/5) Protein of unknown function (DUF4232)
PF07503 (5/5) HypF finger
PF02492 (5/5) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (5/5) Hydrogenase maturation protease
PF01300 (5/5) Telomere recombination
PF01155 (5/5) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (5/5) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (5/5) Acylphosphatase
PF00374 (5/5) Nickel-dependent hydrogenase
TIGR00143 (4/5) carbamoyltransferase HypF
PF17788 (4/5) HypF Kae1-like domain
TIGR02124 (3/5) hydrogenase expression/formation protein HypE
TIGR00075 (3/5) hydrogenase expression/formation protein HypD
TIGR00074 (3/5) hydrogenase assembly chaperone HypC/HupF
PF12833 (3/5) Helix-turn-helix domain
PF12625 (3/5) Arabinose-binding domain of AraC transcription regulator, N-term
PF03583 (3/5) Secretory lipase
PF02769 (3/5) AIR synthase related protein, C-terminal domain
PF01924 (3/5) Hydrogenase formation hypA family
PF01455 (3/5) HupF/HypC family
PF00586 (3/5) AIR synthase related protein, N-terminal domain
precursor_groups_8651 569.88 +- 178.51 3 0 3 3 0.01 +- 0.00 3 4

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (3/3) Radical SAM superfamily
PF00248 (3/3) Aldo/keto reductase family
PF12746 (2/3) GNAT acetyltransferase
precursor_groups_64828 1956.02 +- 301.48 2 0 0 0 0.01 +- 0.00 2 6

PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02449 (2/2) Beta-galactosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_54127 746.09 +- 12.83 2 0 0 0 0.02 +- 0.02 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_groups_8590 42.56 +- 13.89 4 0 0 0 0.09 +- 0.09 4 5

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/4) Major Facilitator Superfamily
PF00107 (4/4) Zinc-binding dehydrogenase
PF01636 (3/4) Phosphotransferase enzyme family
precursor_groups_7915 1600.99 +- 895.71 9 0 9 0 0.01 +- 0.01 9 11

TIGR01733 (9/9) amino acid adenylation domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF13535 (9/9) ATP-grasp domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00975 (9/9) Thioesterase domain
PF00698 (9/9) Acyl transferase domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_26216 134.88 +- 15.76 4 0 0 0 0.20 +- 0.33 4 7

TIGR01915 (4/4) NADPH-dependent F420 reductase
PF13560 (4/4) Helix-turn-helix domain
PF13088 (4/4) BNR repeat-like domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_groups_59201 37.45 +- 0.00 2 0 2 0 0.08 +- 0.05 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF00891 (2/2) O-methyltransferase domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_35953 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
precursor_groups_28511 3085.20 +- 347.42 4 0 4 0 0.01 +- 0.01 4 16

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13560 (4/4) Helix-turn-helix domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13304 (4/4) AAA domain, putative AbiEii toxin, Type IV TA system
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00977 (4/4) Histidine biosynthesis protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00155 (4/4) Aminotransferase class I and II
PF00107 (4/4) Zinc-binding dehydrogenase
PF00005 (4/4) ABC transporter
precursor_groups_4248 664.57 +- 367.43 2 0 2 0 0.02 +- 0.02 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_20766 55.69 +- 1.94 2 0 0 0 0.18 +- 0.23 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13454 (2/2) FAD-NAD(P)-binding
PF02983 (2/2) Alpha-lytic protease prodomain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
PF00005 (2/2) ABC transporter
precursor_groups_80473 388.50 +- 1.50 2 0 0 0 0.01 +- 0.00 2 6

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_1729 51.10 +- 16.01 3 0 0 0 0.13 +- 0.25 3 5

PF13560 (3/3) Helix-turn-helix domain
PF07690 (3/3) Major Facilitator Superfamily
PF04149 (3/3) Domain of unknown function (DUF397)
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_64911 55.71 +- 30.95 2 0 0 0 0.05 +- 0.09 2 2

PF07876 (2/2) Stress responsive A/B Barrel Domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
precursor_groups_34366 1186.67 +- 103.33 2 0 0 0 0.01 +- 0.00 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF14310 (2/2) Fibronectin type III-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_62603 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF11999 (2/2) Protein of unknown function (DUF3494)
PF05199 (2/2) GMC oxidoreductase
PF01833 (2/2) IPT/TIG domain
PF00732 (2/2) GMC oxidoreductase
precursor_groups_4930 143.55 +- 110.11 5 0 0 0 0.09 +- 0.19 5 6

TIGR01180 (5/5) putative alpha-1,2-mannosidase
PF17678 (5/5) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (5/5) Glycosyl hydrolase family 92
PF07488 (5/5) Glycosyl hydrolase family 67 middle domain
PF07477 (5/5) Glycosyl hydrolase family 67 C-terminus
PF00754 (5/5) F5/8 type C domain
precursor_groups_58308 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR02418 (2/2) acetolactate synthase, catabolic
TIGR01252 (2/2) alpha-acetolactate decarboxylase
PF03306 (2/2) Alpha-acetolactate decarboxylase
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_8026 225.75 +- 32.25 2 0 2 2 0.01 +- 0.00 2 4

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_10171 305.69 +- 55.04 8 0 0 0 0.09 +- 0.22 8 16

TIGR03177 (8/8) Flp pilus assembly protein CpaB
PF16976 (8/8) Flp pilus assembly protein RcpC/CpaB
PF15648 (8/8) Restriction endonuclease fold toxin 5
PF13614 (8/8) AAA domain
PF13400 (8/8) Putative Flp pilus-assembly TadE/G-like
PF13231 (8/8) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07811 (8/8) TadE-like protein
PF07730 (8/8) Histidine kinase
PF00691 (8/8) OmpA family
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00496 (8/8) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF00437 (8/8) Type II/IV secretion system protein
PF00196 (8/8) Bacterial regulatory proteins, luxR family
PF00072 (8/8) Response regulator receiver domain
PF00005 (8/8) ABC transporter
precursor_groups_15457 353.47 +- 479.80 3 0 1 2 0.09 +- 0.21 3 4

PF06906 (3/3) Protein of unknown function (DUF1272)
PF13360 (2/3) PQQ-like domain
PF01925 (2/3) Sulfite exporter TauE/SafE
PF01329 (2/3) Pterin 4 alpha carbinolamine dehydratase
precursor_groups_38 134.88 +- 15.76 4 0 0 0 0.20 +- 0.33 4 7

TIGR01915 (4/4) NADPH-dependent F420 reductase
PF13560 (4/4) Helix-turn-helix domain
PF13088 (4/4) BNR repeat-like domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_groups_28603 75.25 +- 32.25 2 0 0 1 0.07 +- 0.13 2 19

TIGR00180 (2/2) ParB/RepB/Spo0J family partition protein
PF13614 (2/2) AAA domain
PF13577 (2/2) SnoaL-like domain
PF02195 (2/2) ParB-like nuclease domain
TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF17929 (1/2) Tetracyclin repressor-like, C-terminal domain
PF17677 (1/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (1/2) Helix-turn-helix domain
PF12852 (1/2) Cupin
PF08535 (1/2) KorB domain
PF07748 (1/2) Glycosyl hydrolases family 38 C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
PF01738 (1/2) Dienelactone hydrolase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family
PF00106 (1/2) short chain dehydrogenase
precursor_groups_1291 266.16 +- 224.48 2 0 1 0 0.04 +- 0.05 2 19

TIGR04444 (1/2) chorismatase, FkbO/Hyg5 family
PF17645 (1/2) Arylmalonate decarboxylase
PF13520 (1/2) Amino acid permease
PF13439 (1/2) Glycosyltransferase Family 4
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF07690 (1/2) Major Facilitator Superfamily
PF06339 (1/2) Ectoine synthase
PF04101 (1/2) Glycosyltransferase family 28 C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02709 (1/2) N-terminal domain of galactosyltransferase
PF01841 (1/2) Transglutaminase-like superfamily
PF01474 (1/2) Class-II DAHP synthetase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_76863 25.84 +- 12.40 2 0 0 0 0.15 +- 0.29 2 6

TIGR00649 (2/2) beta-CASP ribonuclease, RNase J family
PF17770 (2/2) Ribonuclease J C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07521 (2/2) Zn-dependent metallo-hydrolase RNA specificity domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_22580 161.60 +- 98.40 2 0 2 0 0.08 +- 0.25 2 15

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF06094 (2/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF01522 (2/2) Polysaccharide deacetylase
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01039 (1/2) Carboxyl transferase domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_1298 179.29 +- 128.76 17 0 15 17 0.03 +- 0.03 17 3

PF00733 (17/17) Asparagine synthase
PF13302 (16/17) Acetyltransferase (GNAT) domain
PF13471 (15/17) Transglutaminase-like superfamily
precursor_groups_80573 2492.63 +- 2031.37 2 0 0 2 0.03 +- 0.06 2 30

TIGR03812 (2/2) tyrosine decarboxylase MnfA
PF17755 (2/2) UvrA DNA-binding domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF16169 (2/2) Domain of unknown function (DUF4872)
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (2/2) DNA alkylation repair enzyme
PF08241 (2/2) Methyltransferase domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02310 (2/2) B12 binding domain
PF02195 (2/2) ParB-like nuclease domain
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01061 (2/2) ABC-2 type transporter
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00501 (2/2) AMP-binding enzyme
PF00384 (2/2) Molybdopterin oxidoreductase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF12833 (1/2) Helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
precursor_groups_74967 176.61 +- 38.39 2 0 2 0 0.02 +- 0.01 2 3

PF08241 (2/2) Methyltransferase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00348 (2/2) Polyprenyl synthetase
precursor_groups_740 39.67 +- 30.00 4 0 0 0 0.11 +- 0.19 4 9

TIGR03026 (2/4) nucleotide sugar dehydrogenase
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
PF03721 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02156 (2/4) Glycosyl hydrolase family 26
PF00984 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00132 (2/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_17129 22.42 +- 9.83 2 0 0 0 0.11 +- 0.09 2 3

PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01323 (2/2) DSBA-like thioredoxin domain
precursor_groups_1501 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein
precursor_groups_1502 117.58 +- 145.76 14 0 0 0 0.07 +- 0.11 14 2

PF00877 (12/14) NlpC/P60 family
PF11203 (7/14) Putative type VII ESX secretion system translocon, EccE
precursor_groups_4023 16.30 +- 0.43 3 0 0 0 0.25 +- 0.40 3 4

PF13560 (3/3) Helix-turn-helix domain
PF13508 (3/3) Acetyltransferase (GNAT) domain
PF11228 (3/3) Protein of unknown function (DUF3027)
PF04149 (3/3) Domain of unknown function (DUF397)
precursor_groups_1057 198.48 +- 146.27 24 0 23 24 0.04 +- 0.10 24 4

TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF05147 (23/24) Lanthionine synthetase C-like protein
PF14028 (22/24) Lantibiotic biosynthesis dehydratase C-term
PF04738 (21/24) Lantibiotic dehydratase, N terminus
precursor_groups_30846 265.46 +- 77.49 3 0 0 0 0.22 +- 0.21 3 20

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (3/3) FMN reductase
TIGR01728 (3/3) ABC transporter, substrate-binding protein, aliphatic sulfonates family
TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF09084 (3/3) NMT1/THI5 like
PF08445 (3/3) FR47-like protein
PF03358 (3/3) NADPH-dependent FMN reductase
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR00738 (2/3) Rrf2 family protein
PF13410 (2/3) Glutathione S-transferase, C-terminal domain
PF13187 (2/3) 4Fe-4S dicluster domain
PF08028 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02910 (2/3) Fumarate reductase flavoprotein C-term
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/3) Transcriptional regulator
PF00890 (2/3) FAD binding domain
precursor_groups_37819 397.87 +- 89.63 2 0 1 0 0.04 +- 0.10 2 16

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (2/2) Beta-lactamase
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (1/2) amino acid adenylation domain
PF03621 (1/2) MbtH-like protein
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01609 (1/2) Transposase DDE domain
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme
precursor_groups_21565 1183.93 +- 983.27 2 0 2 0 0.07 +- 0.20 2 13

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF03621 (2/2) MbtH-like protein
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (2/2) Aminotransferase class-III
precursor_groups_4029 10.98 +- 0.23 2 0 1 0 0.18 +- 0.18 2 5

PF16697 (2/2) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_37812 27.87 +- 13.97 3 0 0 0 0.10 +- 0.11 3 3

TIGR03696 (3/3) RHS repeat-associated core domain
PF04672 (3/3) S-adenosyl methyltransferase
PF01636 (3/3) Phosphotransferase enzyme family
precursor_groups_80653 225.44 +- 25.27 2 0 0 0 0.04 +- 0.02 2 9

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14310 (2/2) Fibronectin type III-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_49462 126.16 +- 12.76 2 0 2 0 0.17 +- 0.31 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF05534 (2/2) HicB family
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_15071 918.88 +- 398.11 7 0 0 0 0.02 +- 0.01 7 10

PF13407 (7/7) Periplasmic binding protein domain
PF11721 (7/7) Malectin domain
PF10054 (7/7) Predicted periplasmic lipoprotein (DUF2291)
PF07632 (7/7) Protein of unknown function (DUF1593)
PF04198 (7/7) Putative sugar-binding domain
PF03422 (7/7) Carbohydrate binding module (family 6)
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF01261 (7/7) Xylose isomerase-like TIM barrel
PF00801 (7/7) PKD domain
PF00005 (7/7) ABC transporter
precursor_groups_40127 23.19 +- 7.53 3 0 0 0 0.19 +- 0.33 3 12

TIGR02103 (3/3) alpha-1,6-glucosidases, pullulanase-type
PF17967 (3/3) Pullulanase N2 domain
PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF11852 (3/3) Domain of unknown function (DUF3372)
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF03714 (3/3) Bacterial pullanase-associated domain
PF02962 (3/3) 5-carboxymethyl-2-hydroxymuconate isomerase
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02057 (3/3) Glycosyl hydrolase family 59
PF00128 (3/3) Alpha amylase, catalytic domain
PF00072 (3/3) Response regulator receiver domain
precursor_groups_30283 1205.04 +- 76.27 4 0 4 4 0.01 +- 0.00 4 7

TIGR04353 (4/4) PqqD family protein, HPr-rel-A system
TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00005 (4/4) ABC transporter
precursor_groups_60560 1290.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF13242 (2/2) HAD-hyrolase-like
PF06182 (2/2) ABC-2 family transporter protein
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00005 (2/2) ABC transporter
precursor_groups_40278 56.57 +- 48.19 2 0 0 0 0.14 +- 0.10 2 13

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03564 (1/2) F420-dependent oxidoreductase, MSMEG_4879 family
TIGR01392 (1/2) homoserine O-acetyltransferase
TIGR01326 (1/2) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF13671 (1/2) AAA domain
PF07920 (1/2) Protein of unknown function (DUF1684)
PF01638 (1/2) HxlR-like helix-turn-helix
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
precursor_groups_45577 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_44889 21.80 +- 7.09 2 0 2 0 0.10 +- 0.08 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13427 (2/2) Domain of unknown function (DUF4111)
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01909 (2/2) Nucleotidyltransferase domain
precursor_groups_41677 109.47 +- 59.73 3 0 2 0 0.07 +- 0.06 3 4

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF13411 (3/3) MerR HTH family regulatory protein
PF08534 (3/3) Redoxin
PF00701 (3/3) Dihydrodipicolinate synthetase family
precursor_groups_46955 26.26 +- 10.40 3 0 0 0 0.14 +- 0.23 3 3

PF13649 (3/3) Methyltransferase domain
PF00089 (3/3) Trypsin
PF04978 (2/3) Protein of unknown function (DUF664)
precursor_groups_21962 23.69 +- 9.72 5 0 2 0 0.15 +- 0.11 5 5

PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (5/5) BFD-like [2Fe-2S] binding domain
PF02782 (5/5) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00370 (5/5) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_3833 57.86 +- 12.51 2 0 0 0 0.09 +- 0.12 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF08892 (2/2) YqcI/YcgG family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00689 (2/2) Cation transporting ATPase, C-terminus
PF13377 (1/2) Periplasmic binding protein-like domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00122 (1/2) E1-E2 ATPase
precursor_groups_5994 103.17 +- 39.91 6 0 0 0 0.20 +- 0.32 6 11

TIGR03177 (6/6) Flp pilus assembly protein CpaB
PF16976 (6/6) Flp pilus assembly protein RcpC/CpaB
PF08666 (6/6) SAF domain
PF07811 (6/6) TadE-like protein
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF06564 (5/6) Cellulose biosynthesis protein BcsQ
PF00691 (5/6) OmpA family
PF13977 (4/6) BetI-type transcriptional repressor, C-terminal
PF00440 (4/6) Bacterial regulatory proteins, tetR family
precursor_groups_5993 50.05 +- 17.55 2 0 2 0 0.13 +- 0.18 2 27

PF04116 (2/2) Fatty acid hydroxylase superfamily
TIGR01733 (1/2) amino acid adenylation domain
PF17754 (1/2) MftR C-terminal domain
PF16884 (1/2) N-terminal domain of oxidoreductase
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF06386 (1/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (1/2) Gas vesicle synthesis protein GvpO
PF05121 (1/2) Gas vesicle protein K
PF05120 (1/2) Gas vesicle protein G
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00975 (1/2) Thioesterase domain
PF00741 (1/2) Gas vesicle protein
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
precursor_groups_7824 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain
precursor_groups_41225 636.32 +- 221.68 2 0 0 0 0.02 +- 0.03 2 3

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_5193 45.92 +- 25.86 4 0 3 0 0.13 +- 0.13 4 2

PF02031 (4/4) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (4/4) LysE type translocator
precursor_groups_1475 56.36 +- 0.21 3 0 0 0 0.25 +- 0.34 3 9

TIGR00879 (3/3) MFS transporter, sugar porter (SP) family
TIGR00745 (3/3) 2-dehydropantoate 2-reductase
PF08546 (3/3) Ketopantoate reductase PanE/ApbA C terminal
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF02558 (3/3) Ketopantoate reductase PanE/ApbA
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00083 (3/3) Sugar (and other) transporter
precursor_groups_21495 194.83 +- 65.20 3 0 3 3 0.06 +- 0.05 3 6

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_groups_49605 509.69 +- 54.69 2 0 2 0 0.01 +- 0.00 2 9

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
precursor_groups_9242 29.70 +- 3.24 10 0 10 0 0.15 +- 0.15 10 7

PF13620 (10/10) Carboxypeptidase regulatory-like domain
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF11512 (10/10) Agrobacterium tumefaciens protein Atu4866
PF04264 (10/10) YceI-like domain
PF00005 (10/10) ABC transporter
PF04978 (9/10) Protein of unknown function (DUF664)
PF02585 (5/10) GlcNAc-PI de-N-acetylase
precursor_groups_16507 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_7281 37.66 +- 8.65 5 0 2 0 0.14 +- 0.17 5 8

PF17754 (5/5) MftR C-terminal domain
PF08445 (5/5) FR47-like protein
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter
PF13561 (3/5) Enoyl-(Acyl carrier protein) reductase
precursor_groups_14655 29.25 +- 0.75 2 0 2 0 0.12 +- 0.13 2 6

TIGR00377 (2/2) anti-anti-sigma factor
PF13466 (2/2) STAS domain
PF04191 (2/2) Phospholipid methyltransferase
PF02541 (2/2) Ppx/GppA phosphatase family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_2404 152.42 +- 139.42 2 0 1 0 0.08 +- 0.08 2 17

TIGR01733 (1/2) amino acid adenylation domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13649 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08021 (1/2) Siderophore-interacting FAD-binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF04954 (1/2) Siderophore-interacting protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (1/2) Acyl-CoA oxidase
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (1/2) ABC transporter
precursor_groups_2407 66.42 +- 20.13 7 0 0 0 0.04 +- 0.04 7 3

PF18368 (7/7) Exo-beta-D-glucosaminidase Ig-fold domain
PF07166 (7/7) Protein of unknown function (DUF1398)
PF00703 (7/7) Glycosyl hydrolases family 2
precursor_groups_46711 138.06 +- 2.67 2 0 0 0 0.22 +- 0.15 2 12

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00738 (2/2) Rrf2 family protein
PF09084 (2/2) NMT1/THI5 like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/2) Transcriptional regulator
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_groups_6358 258.23 +- 98.52 12 0 0 0 0.03 +- 0.03 12 15

PF17754 (12/12) MftR C-terminal domain
PF14525 (12/12) AraC-binding-like domain
PF12833 (12/12) Helix-turn-helix domain
PF08240 (12/12) Alcohol dehydrogenase GroES-like domain
PF04444 (12/12) Catechol dioxygenase N terminus
PF02776 (12/12) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (12/12) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (12/12) FAD binding domain
PF01425 (12/12) Amidase
PF01047 (12/12) MarR family
PF00775 (12/12) Dioxygenase
PF00465 (12/12) Iron-containing alcohol dehydrogenase
PF00205 (12/12) Thiamine pyrophosphate enzyme, central domain
PF00107 (12/12) Zinc-binding dehydrogenase
PF00106 (12/12) short chain dehydrogenase
precursor_groups_20814 195.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01435 (2/2) Peptidase family M48
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_51956 453.00 +- 63.00 2 0 0 0 0.01 +- 0.00 2 4

PF05853 (2/2) beta-keto acid cleavage enzyme
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_50420 29.66 +- 0.00 2 0 0 0 0.13 +- 0.05 2 5

PF14542 (2/2) GCN5-related N-acetyl-transferase
PF07969 (2/2) Amidohydrolase family
PF07681 (2/2) DoxX
PF06912 (2/2) Protein of unknown function (DUF1275)
PF00857 (2/2) Isochorismatase family
precursor_groups_691 49.30 +- 56.36 3 0 3 0 0.22 +- 0.32 3 11

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01039 (3/3) Carboxyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00364 (3/3) Biotin-requiring enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF16197 (2/3) Ketoacyl-synthetase C-terminal extension
PF14765 (2/3) Polyketide synthase dehydratase
PF13602 (2/3) Zinc-binding dehydrogenase
PF08659 (2/3) KR domain
PF00698 (2/3) Acyl transferase domain
precursor_groups_13454 314.36 +- 46.96 3 0 0 0 0.03 +- 0.05 3 11

PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (2/3) Bacterial extracellular solute-binding protein
PF13229 (2/3) Right handed beta helix region
PF07745 (2/3) Glycosyl hydrolase family 53
PF07532 (2/3) Bacterial Ig-like domain (group 4)
PF04616 (2/3) Glycosyl hydrolases family 43
PF03583 (2/3) Secretory lipase
PF03422 (2/3) Carbohydrate binding module (family 6)
PF01522 (2/3) Polysaccharide deacetylase
PF00754 (2/3) F5/8 type C domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_345 235.26 +- 369.14 60 0 13 2 0.07 +- 0.13 60 12

PF01361 (60/60) Tautomerase enzyme
PF03466 (52/60) LysR substrate binding domain
PF00126 (52/60) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR01524 (33/60) magnesium-translocating P-type ATPase
PF17668 (33/60) Acetyltransferase (GNAT) domain
PF13530 (33/60) Sterol carrier protein domain
PF13527 (33/60) Acetyltransferase (GNAT) domain
PF02308 (33/60) MgtC family
PF00702 (33/60) haloacid dehalogenase-like hydrolase
PF00690 (33/60) Cation transporter/ATPase, N-terminus
PF00689 (33/60) Cation transporting ATPase, C-terminus
PF00122 (33/60) E1-E2 ATPase
precursor_groups_2436 149.68 +- 43.04 4 0 2 0 0.11 +- 0.29 4 23

TIGR01733 (2/4) amino acid adenylation domain
TIGR01141 (2/4) histidinol-phosphate transaminase
TIGR00797 (2/4) MATE efflux family protein
PF14269 (2/4) Arylsulfotransferase (ASST)
PF13649 (2/4) Methyltransferase domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF08545 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (2/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/4) Acyl-CoA dehydrogenase, middle domain
PF02423 (2/4) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/4) MatE
PF01497 (2/4) Periplasmic binding protein
PF00860 (2/4) Permease family
PF00664 (2/4) ABC transporter transmembrane region
PF00652 (2/4) Ricin-type beta-trefoil lectin domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00441 (2/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme
PF00155 (2/4) Aminotransferase class I and II
PF00005 (2/4) ABC transporter
precursor_groups_1188 180.76 +- 121.38 4 0 4 0 0.08 +- 0.16 4 15

TIGR03150 (4/4) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR00517 (4/4) acyl carrier protein
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00171 (4/4) Aldehyde dehydrogenase family
PF00155 (4/4) Aminotransferase class I and II
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1189 226.97 +- 160.03 2 0 0 0 0.12 +- 0.25 2 15

TIGR03005 (1/2) ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA
TIGR03004 (1/2) ectoine/hydroxyectoine ABC transporter, permease protein EhuC
TIGR03003 (1/2) ectoine/hydroxyectoine ABC transporter, permease protein EhuD
TIGR02995 (1/2) ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB
PF17645 (1/2) Arylmalonate decarboxylase
PF09339 (1/2) IclR helix-turn-helix domain
PF04464 (1/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF04138 (1/2) GtrA-like protein
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01614 (1/2) Bacterial transcriptional regulator
PF01425 (1/2) Amidase
PF00535 (1/2) Glycosyl transferase family 2
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (1/2) ABC transporter
precursor_groups_23430 130.76 +- 113.43 4 0 0 0 0.09 +- 0.23 4 4

PF13560 (4/4) Helix-turn-helix domain
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF00069 (4/4) Protein kinase domain
precursor_groups_58150 57.15 +- 11.27 2 0 0 0 0.06 +- 0.08 2 15

TIGR03026 (1/2) nucleotide sugar dehydrogenase
TIGR01208 (1/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (1/2) dTDP-glucose 4,6-dehydratase
PF16363 (1/2) GDP-mannose 4,6 dehydratase
PF13489 (1/2) Methyltransferase domain
PF13384 (1/2) Homeodomain-like domain
PF08484 (1/2) C-methyltransferase C-terminal domain
PF08421 (1/2) Putative zinc binding domain
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03559 (1/2) NDP-hexose 2,3-dehydratase
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (1/2) Glycosyl transferase family 2
PF00483 (1/2) Nucleotidyl transferase
precursor_groups_14259 293.75 +- 130.25 7 0 3 0 0.04 +- 0.16 7 7

TIGR01733 (7/7) amino acid adenylation domain
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF07690 (7/7) Major Facilitator Superfamily
PF00975 (7/7) Thioesterase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
precursor_groups_70666 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_groups_36039 38.01 +- 2.35 2 0 0 0 0.21 +- 0.23 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF01427 (2/2) D-ala-D-ala dipeptidase
precursor_groups_46139 286.45 +- 187.28 3 0 0 0 0.03 +- 0.05 3 12

TIGR00229 (3/3) PAS domain S-box protein
PF17203 (3/3) Single cache domain 3
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01590 (3/3) GAF domain
PF00989 (3/3) PAS fold
PF07969 (2/3) Amidohydrolase family
PF07729 (2/3) FCD domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_groups_76120 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_49114 482.86 +- 37.14 2 0 0 0 0.02 +- 0.01 2 8

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_5370 8.57 +- 0.00 2 0 0 0 0.23 +- 0.31 2 3

TIGR02469 (2/2) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
TIGR01465 (2/2) precorrin-4 C11-methyltransferase
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
precursor_groups_56867 36.90 +- 9.53 2 0 0 0 0.13 +- 0.14 2 12

PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
PF03625 (1/2) Domain of unknown function DUF302
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00027 (1/2) Cyclic nucleotide-binding domain
precursor_groups_17122 216.46 +- 59.99 6 0 0 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (6/6) YbaB/EbfC DNA-binding family
PF04488 (5/6) Glycosyltransferase sugar-binding region containing DXD motif
precursor_groups_24283 3085.20 +- 347.42 4 0 4 0 0.01 +- 0.01 4 16

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13560 (4/4) Helix-turn-helix domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13304 (4/4) AAA domain, putative AbiEii toxin, Type IV TA system
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00977 (4/4) Histidine biosynthesis protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00155 (4/4) Aminotransferase class I and II
PF00107 (4/4) Zinc-binding dehydrogenase
PF00005 (4/4) ABC transporter
precursor_groups_16430 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_24285 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF12802 (2/2) MarR family
PF09335 (2/2) SNARE associated Golgi protein
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain
precursor_groups_29391 48.41 +- 31.27 2 0 1 0 0.16 +- 0.14 2 10

PF17648 (2/2) Family of unknown function (DUF5519)
PF13377 (2/2) Periplasmic binding protein-like domain
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (2/2) Glycosyl hydrolase family 12
PF00553 (2/2) Cellulose binding domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF13569 (1/2) Domain of unknown function (DUF4132)
PF13411 (1/2) MerR HTH family regulatory protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF02767 (1/2) DNA polymerase III beta subunit, central domain
precursor_groups_2575 187.61 +- 144.53 13 0 13 0 0.08 +- 0.17 13 4

PF07690 (13/13) Major Facilitator Superfamily
PF03756 (13/13) A-factor biosynthesis hotdog domain
PF00916 (13/13) Sulfate permease family
PF00484 (13/13) Carbonic anhydrase
precursor_groups_63631 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_2140 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family
precursor_groups_84793 615.47 +- 545.53 2 0 2 0 0.07 +- 0.20 2 14

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF03621 (2/2) MbtH-like protein
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00697 (2/2) N-(5'phosphoribosyl)anthranilate (PRA) isomerase
PF00591 (2/2) Glycosyl transferase family, a/b domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
precursor_groups_63639 136.44 +- 123.56 2 0 0 0 0.08 +- 0.15 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09286 (2/2) Pro-kumamolisin, activation domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF00082 (2/2) Subtilase family
precursor_groups_39099 402.66 +- 235.52 2 0 0 0 0.02 +- 0.02 2 5

PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_53136 200.54 +- 186.46 2 0 0 0 0.07 +- 0.14 2 8

PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF11361 (2/2) Protein of unknown function (DUF3159)
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00667 (1/2) FAD binding domain
PF00258 (1/2) Flavodoxin
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00067 (1/2) Cytochrome P450
precursor_groups_34945 30.60 +- 5.27 3 0 0 0 0.11 +- 0.14 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12806 (3/3) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (3/3) Acyl-CoA dehydrogenase N terminal
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00664 (3/3) ABC transporter transmembrane region
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_33137 43.20 +- 22.07 3 0 1 0 0.10 +- 0.07 3 5

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03919 (3/3) type VII secretion protein EccB
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/3) YbaB/EbfC DNA-binding family
precursor_groups_84800 148.29 +- 74.57 2 0 0 0 0.03 +- 0.02 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_36452 77.19 +- 36.56 2 0 0 0 0.15 +- 0.20 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
precursor_groups_42218 1361.71 +- 233.20 2 0 0 0 0.02 +- 0.00 2 17

TIGR02118 (2/2) conserved hypothetical protein
TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07110 (2/2) EthD domain
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF01636 (2/2) Phosphotransferase enzyme family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00108 (2/2) Thiolase, N-terminal domain
precursor_groups_1223 47.59 +- 37.42 39 0 1 0 0.12 +- 0.11 39 5

PF00561 (38/39) alpha/beta hydrolase fold
TIGR00456 (36/39) arginine--tRNA ligase
PF05746 (36/39) DALR anticodon binding domain
PF03485 (36/39) Arginyl tRNA synthetase N terminal domain
PF00750 (36/39) tRNA synthetases class I (R)
precursor_groups_2976 362.99 +- 177.76 6 0 0 0 0.02 +- 0.01 6 6

PF07690 (6/6) Major Facilitator Superfamily
PF04909 (6/6) Amidohydrolase
PF04444 (6/6) Catechol dioxygenase N terminus
PF01494 (6/6) FAD binding domain
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_groups_14492 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II
precursor_groups_47843 19.22 +- 6.18 3 0 0 0 0.15 +- 0.25 3 4

PF13641 (3/3) Glycosyltransferase like family 2
PF01757 (3/3) Acyltransferase family
PF01522 (3/3) Polysaccharide deacetylase
PF01381 (2/3) Helix-turn-helix
precursor_groups_35422 10.29 +- 0.89 3 0 3 0 0.19 +- 0.39 3 6

TIGR00876 (3/3) transaldolase
PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF01590 (3/3) GAF domain
PF00923 (3/3) Transaldolase/Fructose-6-phosphate aldolase
precursor_groups_24048 111.82 +- 15.07 2 0 2 0 0.22 +- 0.29 2 7

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF03412 (2/2) Peptidase C39 family
PF01436 (2/2) NHL repeat
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_521 40.65 +- 5.03 3 0 0 0 0.09 +- 0.15 3 7

TIGR00924 (2/3) amino acid/peptide transporter (Peptide:H+ symporter)
PF13560 (2/3) Helix-turn-helix domain
PF13520 (2/3) Amino acid permease
PF11716 (2/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07883 (2/3) Cupin domain
PF01266 (2/3) FAD dependent oxidoreductase
PF00854 (2/3) POT family
precursor_groups_11900 107.83 +- 59.26 7 0 0 0 0.04 +- 0.06 7 2

PF01557 (7/7) Fumarylacetoacetate (FAA) hydrolase family
PF00753 (7/7) Metallo-beta-lactamase superfamily
precursor_groups_9451 167.40 +- 12.60 2 0 2 0 0.02 +- 0.01 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF03795 (2/2) YCII-related domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_13207 499.47 +- 326.13 2 0 0 0 0.02 +- 0.03 2 11

PF13333 (1/2) Integrase core domain
PF12146 (1/2) Serine aminopeptidase, S33
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/2) FAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/2) Integrase core domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00106 (1/2) short chain dehydrogenase
precursor_groups_529 320.96 +- 334.05 3 0 0 0 0.08 +- 0.10 3 10

PF00005 (3/3) ABC transporter
PF13646 (2/3) HEAT repeats
PF12838 (2/3) 4Fe-4S dicluster domain
PF09084 (2/3) NMT1/THI5 like
PF07702 (2/3) UTRA domain
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF02910 (2/3) Fumarate reductase flavoprotein C-term
PF00890 (2/3) FAD binding domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_groups_13335 720.73 +- 236.74 7 0 7 7 0.01 +- 0.01 7 12

TIGR00730 (7/7) TIGR00730 family protein
PF14833 (7/7) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (7/7) Glutamine amidotransferase domain
PF13480 (7/7) Acetyltransferase (GNAT) domain
PF07690 (7/7) Major Facilitator Superfamily
PF03641 (7/7) Possible lysine decarboxylase
PF03446 (7/7) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (7/7) N-terminal domain of galactosyltransferase
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (7/7) Asparagine synthase
PF00535 (7/7) Glycosyl transferase family 2
PF00300 (7/7) Histidine phosphatase superfamily (branch 1)
precursor_groups_42234 236.50 +- 30.41 3 0 0 0 0.01 +- 0.00 3 4

PF13631 (3/3) Cytochrome b(N-terminal)/b6/petB
PF13466 (3/3) STAS domain
PF03861 (3/3) ANTAR domain
PF01590 (3/3) GAF domain
precursor_groups_114 339.00 +- 177.59 7 0 1 0 0.08 +- 0.12 7

No common domains found
precursor_groups_2993 18.33 +- 4.51 2 0 2 0 0.19 +- 0.29 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03176 (2/2) MMPL family
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13426 (1/2) PAS domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01590 (1/2) GAF domain
PF00989 (1/2) PAS fold
precursor_groups_26935 275.73 +- 48.75 4 0 0 0 0.03 +- 0.03 4 12

PF13977 (4/4) BetI-type transcriptional repressor, C-terminal
PF13607 (4/4) Succinyl-CoA ligase like flavodoxin domain
PF13549 (4/4) ATP-grasp domain
PF13380 (4/4) CoA binding domain
PF13279 (4/4) Thioesterase-like superfamily
PF07729 (4/4) FCD domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
precursor_groups_46222 441.12 +- 171.82 3 0 0 0 0.05 +- 0.11 3 6

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03919 (3/3) type VII secretion protein EccB
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_groups_84370 488.69 +- 32.58 2 0 0 0 0.05 +- 0.02 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF04341 (2/2) Protein of unknown function, DUF485
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01381 (2/2) Helix-turn-helix
PF01212 (2/2) Beta-eliminating lyase
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00474 (2/2) Sodium:solute symporter family
precursor_groups_25179 241.43 +- 18.57 2 0 0 2 0.01 +- 0.00 2 9

TIGR04276 (2/2) FxsC C-terminal domain
TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13614 (2/2) AAA domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF04055 (2/2) Radical SAM superfamily
PF02522 (2/2) Aminoglycoside 3-N-acetyltransferase
precursor_groups_13078 1024.31 +- 951.63 6 1 1 4 0.04 +- 0.16 5 19

PF03176 (6/6) MMPL family
PF08241 (5/6) Methyltransferase domain
PF00698 (5/6) Acyl transferase domain
PF00550 (5/6) Phosphopantetheine attachment site
PF00202 (5/6) Aminotransferase class-III
PF00196 (5/6) Bacterial regulatory proteins, luxR family
TIGR03605 (4/6) SagB-type dehydrogenase domain
TIGR03604 (4/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/6) Enoyl-(Acyl carrier protein) reductase
PF07993 (4/6) Male sterility protein
PF03364 (4/6) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/6) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01575 (4/6) MaoC like domain
PF00881 (4/6) Nitroreductase family
PF00109 (4/6) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/6) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/6) MOSC domain
PF00675 (3/6) Insulinase (Peptidase family M16)
precursor_groups_25241 15.83 +- 2.49 3 0 0 0 0.19 +- 0.25 3 6

PF09350 (3/3) Domain of unknown function (DUF1992)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
precursor_groups_83810 315.24 +- 11.34 2 0 0 0 0.04 +- 0.04 2 14

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF12307 (2/2) Protein of unknown function (DUF3631)
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF00583 (2/2) Acetyltransferase (GNAT) family
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF17802 (1/2) Prealbumin-like fold domain
PF01555 (1/2) DNA methylase
precursor_groups_83101 199.03 +- 100.12 2 0 0 0 0.17 +- 0.30 2 18

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF13518 (1/2) Helix-turn-helix domain
PF13401 (1/2) AAA domain
PF09299 (1/2) Mu transposase, C-terminal
PF08722 (1/2) TnsA endonuclease N terminal
PF06527 (1/2) TniQ
PF00665 (1/2) Integrase core domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_2756 20.22 +- 8.95 4 0 0 0 0.16 +- 0.22 4 5

TIGR00099 (2/4) Cof-like hydrolase
PF09335 (2/4) SNARE associated Golgi protein
PF08282 (2/4) haloacid dehalogenase-like hydrolase
PF01522 (2/4) Polysaccharide deacetylase
PF00457 (2/4) Glycosyl hydrolases family 11
precursor_groups_2757 125.00 +- 47.00 2 0 0 0 0.03 +- 0.04 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_2977 177.87 +- 109.73 22 0 3 0 0.14 +- 0.17 22 6

PF00528 (22/22) Binding-protein-dependent transport system inner membrane component
PF00005 (22/22) ABC transporter
PF09084 (20/22) NMT1/THI5 like
PF02668 (20/22) Taurine catabolism dioxygenase TauD, TfdA family
TIGR03860 (12/22) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (12/22) Luciferase-like monooxygenase
precursor_groups_80380 98.70 +- 47.55 2 0 0 0 0.18 +- 0.27 2 11

TIGR01762 (2/2) chlorinating enzyme
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR01426 (1/2) glycosyltransferase, MGT family
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00975 (1/2) Thioesterase domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_13700 133.87 +- 64.11 5 0 0 0 0.05 +- 0.15 5 3

PF13343 (5/5) Bacterial extracellular solute-binding protein
PF00561 (5/5) alpha/beta hydrolase fold
PF00485 (5/5) Phosphoribulokinase / Uridine kinase family
precursor_groups_47289 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_groups_35420 69.35 +- 15.97 3 0 0 0 0.19 +- 0.11 3 4

PF07811 (3/3) TadE-like protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF13400 (2/3) Putative Flp pilus-assembly TadE/G-like
precursor_groups_13708 147.14 +- 110.86 2 0 2 0 0.13 +- 0.28 2 17

TIGR01733 (1/2) amino acid adenylation domain
TIGR01179 (1/2) UDP-glucose 4-epimerase GalE
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF13535 (1/2) ATP-grasp domain
PF05977 (1/2) Transmembrane secretion effector
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04030 (1/2) D-arabinono-1,4-lactone oxidase
PF02222 (1/2) ATP-grasp domain
PF01565 (1/2) FAD binding domain
PF01522 (1/2) Polysaccharide deacetylase
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00248 (1/2) Aldo/keto reductase family
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
precursor_groups_38701 18.15 +- 3.82 3 0 0 0 0.18 +- 0.33 3 7

PF17996 (3/3) Carbohydrate esterase 2 N-terminal
PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01012 (3/3) Electron transfer flavoprotein domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
precursor_groups_239 324.14 +- 382.59 69 0 44 15 0.10 +- 0.15 69 12

TIGR01525 (68/69) heavy metal translocating P-type ATPase
PF00702 (68/69) haloacid dehalogenase-like hydrolase
PF00403 (68/69) Heavy-metal-associated domain
PF00122 (68/69) E1-E2 ATPase
PF04314 (67/69) Copper chaperone PCu(A)C
PF01497 (50/69) Periplasmic binding protein
PF01032 (50/69) FecCD transport family
PF00005 (50/69) ABC transporter
PF07690 (48/69) Major Facilitator Superfamily
TIGR02937 (36/69) RNA polymerase sigma factor, sigma-70 family
PF08281 (36/69) Sigma-70, region 4
PF04542 (36/69) Sigma-70 region 2
precursor_groups_53143 20.67 +- 2.10 2 0 0 0 0.10 +- 0.10 2 3

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_47282 57.75 +- 16.78 3 0 0 0 0.04 +- 0.03 3 3

TIGR03561 (3/3) peroxiredoxin, Ohr subfamily
PF02566 (3/3) OsmC-like protein
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_48894 118.75 +- 11.25 2 0 0 0 0.08 +- 0.11 2 7

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_57141 123.37 +- 26.63 2 0 2 0 0.03 +- 0.02 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF11239 (2/2) Protein of unknown function (DUF3040)
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
precursor_groups_53789 59.24 +- 5.76 2 0 2 0 0.14 +- 0.21 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09997 (2/2) Predicted membrane protein (DUF2238)
PF07690 (2/2) Major Facilitator Superfamily
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_16721 952.16 +- 734.28 6 0 0 0 0.04 +- 0.14 6 13

TIGR01726 (6/6) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF17853 (6/6) GGDEF-like domain
PF13556 (6/6) PucR C-terminal helix-turn-helix domain
PF07978 (6/6) NIPSNAP
PF07969 (6/6) Amidohydrolase family
PF02627 (6/6) Carboxymuconolactone decarboxylase family
PF01613 (6/6) Flavin reductase like domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00497 (6/6) Bacterial extracellular solute-binding proteins, family 3
PF00296 (6/6) Luciferase-like monooxygenase
PF00264 (6/6) Common central domain of tyrosinase
PF00171 (6/6) Aldehyde dehydrogenase family
PF00005 (6/6) ABC transporter
precursor_groups_64591 207.91 +- 18.18 2 0 2 0 0.03 +- 0.05 2 8

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07730 (2/2) Histidine kinase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_56948 134.11 +- 4.11 2 0 0 0 0.06 +- 0.09 2 15

TIGR03356 (2/2) beta-galactosidase
PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF02055 (2/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01590 (2/2) GAF domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_837 340.31 +- 402.86 3 0 0 0 0.03 +- 0.09 3

No common domains found
precursor_groups_76582 1295.00 +- 5.00 2 0 0 2 0.01 +- 0.00 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_22609 215.00 +- 43.00 4 0 0 0 0.01 +- 0.00 4 4

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF02894 (4/4) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_groups_81058 85.77 +- 37.61 2 0 0 0 0.12 +- 0.24 2 10

TIGR02815 (2/2) putative sugar isomerase, AgaS family
TIGR02810 (2/2) D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF08013 (2/2) Tagatose 6 phosphate kinase
PF07702 (2/2) UTRA domain
PF01869 (2/2) BadF/BadG/BcrA/BcrD ATPase family
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_2192 715.00 +- 455.00 2 0 2 0 0.01 +- 0.00 2 16

TIGR01733 (1/2) amino acid adenylation domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/2) Enolase C-terminal domain-like
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12146 (1/2) Serine aminopeptidase, S33
PF06863 (1/2) Protein of unknown function (DUF1254)
PF06742 (1/2) Protein of unknown function (DUF1214)
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (1/2) GH3 auxin-responsive promoter
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02656 (1/2) Domain of unknown function (DUF202)
PF00694 (1/2) Aconitase C-terminal domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00330 (1/2) Aconitase family (aconitate hydratase)
precursor_groups_11757 634.33 +- 1003.92 6 0 6 0 0.13 +- 0.25 6 20

TIGR03945 (6/6) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (6/6) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (6/6) amino acid adenylation domain
TIGR01327 (6/6) phosphoglycerate dehydrogenase
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF12697 (6/6) Alpha/beta hydrolase family
PF07977 (6/6) FabA-like domain
PF04073 (6/6) Aminoacyl-tRNA editing domain
PF03621 (6/6) MbtH-like protein
PF02826 (6/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (6/6) Ornithine cyclodeaminase/mu-crystallin family
PF01323 (6/6) DSBA-like thioredoxin domain
PF00975 (6/6) Thioesterase domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_71272 63.98 +- 1.65 2 0 2 0 0.23 +- 0.31 2 11

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13478 (2/2) XdhC Rossmann domain
PF07883 (2/2) Cupin domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_71273 207.91 +- 18.18 2 0 2 0 0.03 +- 0.05 2 8

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07730 (2/2) Histidine kinase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_75568 67.49 +- 26.86 2 0 0 0 0.21 +- 0.05 2 4

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_47063 605.13 +- 492.43 3 0 0 0 0.03 +- 0.05 3 10

PF14310 (3/3) Fibronectin type III-like domain
PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF03636 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (3/3) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (3/3) Glycosyl hydrolase family 65 central catalytic domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
precursor_groups_75565 334.54 +- 310.46 2 0 0 0 0.11 +- 0.22 2 8

PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_75563 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 2

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00069 (2/2) Protein kinase domain
precursor_groups_79452 372.32 +- 128.18 2 0 0 0 0.03 +- 0.03 2 9

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_79108 29.88 +- 1.21 2 0 0 0 0.13 +- 0.16 2 3

TIGR01755 (2/2) NAD(P)H:quinone oxidoreductase, type IV
PF08445 (2/2) FR47-like protein
PF03358 (2/2) NADPH-dependent FMN reductase
precursor_groups_29415 256.01 +- 202.81 3 0 0 0 0.06 +- 0.13 3 3

PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
precursor_groups_18946 33.79 +- 9.21 2 0 0 0 0.06 +- 0.02 2 2

PF13649 (2/2) Methyltransferase domain
PF11139 (2/2) Sap, sulfolipid-1-addressing protein
precursor_groups_43141 51.43 +- 5.90 2 0 0 0 0.04 +- 0.03 2 1

PF00106 (2/2) short chain dehydrogenase
precursor_groups_52143 140.66 +- 30.94 2 0 0 0 0.11 +- 0.11 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12802 (2/2) MarR family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_42658 63.18 +- 10.53 2 0 0 0 0.20 +- 0.21 2 9

PF16262 (2/2) Domain of unknown function (DUF4916)
PF14230 (2/2) Domain of unknown function (DUF4333)
PF04909 (2/2) Amidohydrolase
PF04672 (2/2) S-adenosyl methyltransferase
PF01494 (2/2) FAD binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_2359 12.07 +- 2.79 2 0 2 0 0.17 +- 0.21 2 4

PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF13520 (1/2) Amino acid permease
PF00324 (1/2) Amino acid permease
precursor_groups_51611 96.13 +- 68.66 2 0 1 0 0.11 +- 0.21 2 20

PF13460 (2/2) NAD(P)H-binding
TIGR02957 (1/2) RNA polymerase sigma-70 factor, TIGR02957 family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00027 (1/2) methyltransferase, TIGR00027 family
PF14016 (1/2) Protein of unknown function (DUF4232)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08281 (1/2) Sigma-70, region 4
PF08241 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF04542 (1/2) Sigma-70 region 2
PF04264 (1/2) YceI-like domain
PF04072 (1/2) Leucine carboxyl methyltransferase
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03321 (1/2) GH3 auxin-responsive promoter
PF02910 (1/2) Fumarate reductase flavoprotein C-term
PF02796 (1/2) Helix-turn-helix domain of resolvase
PF01695 (1/2) IstB-like ATP binding protein
PF00890 (1/2) FAD binding domain
PF00665 (1/2) Integrase core domain
PF00483 (1/2) Nucleotidyl transferase
precursor_groups_64041 14.74 +- 0.08 2 0 0 0 0.14 +- 0.13 2 5

PF12950 (2/2) TaqI-like C-terminal specificity domain
PF07669 (2/2) Eco57I restriction-modification methylase
PF04555 (2/2) Restriction endonuclease XhoI
PF02441 (2/2) Flavoprotein
PF00293 (2/2) NUDIX domain
precursor_groups_16658 19.34 +- 2.39 6 0 5 0 0.16 +- 0.05 6 4

TIGR00791 (6/6) transporter, gluconate:H+ symporter (GntP) family
PF13378 (6/6) Enolase C-terminal domain-like
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02447 (6/6) GntP family permease
precursor_groups_67637 3900.00 +- 780.00 2 0 2 2 0.01 +- 0.00 2 10

TIGR04267 (2/2) HEXXH motif domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF13535 (2/2) ATP-grasp domain
PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
precursor_groups_78912 184.36 +- 28.36 2 0 0 0 0.02 +- 0.01 2 5

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_75108 1258.84 +- 54.84 2 0 2 0 0.02 +- 0.05 2 9

TIGR00830 (2/2) PTS system, glucose subfamily, IIA component
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00069 (2/2) Protein kinase domain
precursor_groups_28205 1427.00 +- 223.49 4 0 0 0 0.01 +- 0.00 4 7

PF13480 (4/4) Acetyltransferase (GNAT) domain
PF08892 (4/4) YqcI/YcgG family
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01725 (4/4) Ham1 family
PF00590 (4/4) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_83922 85.68 +- 34.77 2 0 2 0 0.16 +- 0.30 2 14

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR03086 (1/2) TIGR03086 family protein
TIGR00765 (1/2) YihY family inner membrane protein
PF13411 (1/2) MerR HTH family regulatory protein
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03631 (1/2) Virulence factor BrkB
precursor_groups_52368 602.85 +- 47.15 2 0 2 0 0.01 +- 0.01 2 17

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF08242 (2/2) Methyltransferase domain
PF04820 (2/2) Tryptophan halogenase
PF03061 (2/2) Thioesterase superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_22086 26.87 +- 2.68 2 0 2 0 0.11 +- 0.06 2 7

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
precursor_groups_74369 232.44 +- 85.01 2 0 0 0 0.05 +- 0.04 2 19

PF13602 (2/2) Zinc-binding dehydrogenase
PF13546 (2/2) DDE superfamily endonuclease
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00501 (2/2) AMP-binding enzyme
PF00384 (2/2) Molybdopterin oxidoreductase
TIGR04316 (1/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF03358 (1/2) NADPH-dependent FMN reductase
PF01494 (1/2) FAD binding domain
PF01474 (1/2) Class-II DAHP synthetase family
PF00857 (1/2) Isochorismatase family
PF00425 (1/2) chorismate binding enzyme
PF00117 (1/2) Glutamine amidotransferase class-I
PF00106 (1/2) short chain dehydrogenase
precursor_groups_55400 351.00 +- 39.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_59975 56.13 +- 10.60 2 0 0 0 0.09 +- 0.09 2 9

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF12973 (2/2) ChrR Cupin-like domain
PF01909 (2/2) Nucleotidyltransferase domain
PF00144 (2/2) Beta-lactamase
PF07876 (1/2) Stress responsive A/B Barrel Domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_56041 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_74561 46.67 +- 0.00 2 0 1 0 0.09 +- 0.11 2 5

PF12146 (2/2) Serine aminopeptidase, S33
PF11338 (2/2) Protein of unknown function (DUF3140)
PF04909 (2/2) Amidohydrolase
PF04672 (2/2) S-adenosyl methyltransferase
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_10050 314.19 +- 225.10 7 0 1 0 0.03 +- 0.08 7 8

PF13424 (7/7) Tetratricopeptide repeat
PF07690 (7/7) Major Facilitator Superfamily
PF03781 (7/7) Sulfatase-modifying factor enzyme 1
PF03704 (7/7) Bacterial transcriptional activator domain
PF03358 (7/7) NADPH-dependent FMN reductase
PF00931 (7/7) NB-ARC domain
PF00925 (7/7) GTP cyclohydrolase II
PF00400 (7/7) WD domain, G-beta repeat
precursor_groups_42231 33.44 +- 6.56 2 0 0 0 0.12 +- 0.09 2 9

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00689 (2/2) sugar-phosphate isomerase, RpiB/LacA/LacB family
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_22333 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6
precursor_groups_18839 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_3040 774.42 +- 236.12 3 0 0 0 0.04 +- 0.01 3 13

PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (3/3) Fibronectin type III-like domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF02055 (3/3) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (3/3) IPT/TIG domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00754 (3/3) F5/8 type C domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_29018 410.25 +- 124.26 4 0 0 0 0.01 +- 0.01 4 6

PF13599 (4/4) Pentapeptide repeats (9 copies)
PF13489 (4/4) Methyltransferase domain
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF08445 (2/4) FR47-like protein
PF07730 (2/4) Histidine kinase
PF00583 (2/4) Acetyltransferase (GNAT) family
precursor_groups_17917 519.00 +- 261.00 2 0 0 0 0.01 +- 0.00 2 4

PF14478 (2/2) Domain of unknown function (DUF4430)
PF13377 (2/2) Periplasmic binding protein-like domain
PF01301 (2/2) Glycosyl hydrolases family 35
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_70192 81.28 +- 51.51 2 0 0 2 0.08 +- 0.10 2 10

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/2) Glutamine amidotransferase domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02195 (2/2) ParB-like nuclease domain
PF00733 (2/2) Asparagine synthase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF00067 (1/2) Cytochrome P450
precursor_groups_65403 470.31 +- 131.69 2 0 2 0 0.03 +- 0.07 2 12

TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF05199 (2/2) GMC oxidoreductase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00732 (2/2) GMC oxidoreductase
PF00664 (2/2) ABC transporter transmembrane region
PF00483 (2/2) Nucleotidyl transferase
PF00005 (2/2) ABC transporter
precursor_groups_76479 91.64 +- 35.99 2 0 2 0 0.11 +- 0.23 2 23

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13535 (2/2) ATP-grasp domain
PF13444 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13185 (2/2) GAF domain
PF09335 (2/2) SNARE associated Golgi protein
PF08544 (2/2) GHMP kinases C terminal
PF08447 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01553 (2/2) Acyltransferase
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00206 (2/2) Lyase
PF02274 (1/2) Amidinotransferase
precursor_groups_22731 138.78 +- 72.03 2 0 0 0 0.15 +- 0.30 2 23

TIGR01122 (2/2) branched-chain amino acid aminotransferase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07690 (2/2) Major Facilitator Superfamily
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF02222 (2/2) ATP-grasp domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF01063 (2/2) Amino-transferase class IV
PF00069 (2/2) Protein kinase domain
TIGR01060 (1/2) phosphopyruvate hydratase
PF13624 (1/2) SurA N-terminal domain
PF06737 (1/2) Transglycosylase-like domain
PF04977 (1/2) Septum formation initiator
PF03952 (1/2) Enolase, N-terminal domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01476 (1/2) LysM domain
PF00113 (1/2) Enolase, C-terminal TIM barrel domain
PF00067 (1/2) Cytochrome P450
precursor_groups_78438 272.17 +- 18.67 2 0 0 0 0.05 +- 0.07 2 9

PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02633 (2/2) Creatinine amidohydrolase
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF04149 (1/2) Domain of unknown function (DUF397)
precursor_groups_60223 19.31 +- 0.66 2 0 0 0 0.16 +- 0.22 2 7

TIGR00765 (2/2) YihY family inner membrane protein
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03631 (2/2) Virulence factor BrkB
PF01613 (2/2) Flavin reductase like domain
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_groups_19666 312.34 +- 188.17 4 0 2 0 0.08 +- 0.22 4 12

TIGR03841 (4/4) probable F420-dependent oxidoreductase, Rv3093c family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
PF03992 (2/4) Antibiotic biosynthesis monooxygenase
PF02738 (2/4) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/4) [2Fe-2S] binding domain
PF01315 (2/4) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/4) FAD binding domain in molybdopterin dehydrogenase
PF00294 (2/4) pfkB family carbohydrate kinase
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_6879 424.27 +- 220.30 11 0 7 0 0.06 +- 0.03 11 18

PF13561 (11/11) Enoyl-(Acyl carrier protein) reductase
PF08545 (11/11) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (11/11) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (11/11) Beta-ketoacyl synthase, C-terminal domain
PF01144 (11/11) Coenzyme A transferase
PF00378 (11/11) Enoyl-CoA hydratase/isomerase
PF00196 (11/11) Bacterial regulatory proteins, luxR family
PF00109 (11/11) Beta-ketoacyl synthase, N-terminal domain
PF00106 (11/11) short chain dehydrogenase
PF00005 (11/11) ABC transporter
PF12679 (10/11) ABC-2 family transporter protein
TIGR00976 (9/11) hydrolase CocE/NonD family protein
PF13193 (9/11) AMP-binding enzyme C-terminal domain
PF08530 (9/11) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/11) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/11) AMP-binding enzyme
PF04909 (8/11) Amidohydrolase
PF12697 (7/11) Alpha/beta hydrolase family
precursor_groups_74215 64.36 +- 29.46 2 0 0 0 0.16 +- 0.31 2 10

TIGR01788 (2/2) glutamate decarboxylase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13560 (2/2) Helix-turn-helix domain
PF13365 (2/2) Trypsin-like peptidase domain
PF10901 (2/2) Protein of unknown function (DUF2690)
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_74746 126.13 +- 80.27 2 0 2 2 0.11 +- 0.23 2 17

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13471 (2/2) Transglutaminase-like superfamily
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR01373 (1/2) sarcosine oxidase, beta subunit family
PF01266 (1/2) FAD dependent oxidoreductase
PF00464 (1/2) Serine hydroxymethyltransferase
precursor_groups_47622 486.72 +- 0.00 2 0 0 0 0.04 +- 0.02 2 10

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_8904 18.53 +- 4.88 9 0 0 0 0.23 +- 0.36 9 11

TIGR02103 (9/9) alpha-1,6-glucosidases, pullulanase-type
PF17967 (9/9) Pullulanase N2 domain
PF11852 (9/9) Domain of unknown function (DUF3372)
PF07228 (9/9) Stage II sporulation protein E (SpoIIE)
PF03714 (9/9) Bacterial pullanase-associated domain
PF02962 (9/9) 5-carboxymethyl-2-hydroxymuconate isomerase
PF02922 (9/9) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (9/9) Alpha amylase, C-terminal all-beta domain
PF00686 (9/9) Starch binding domain
PF00128 (9/9) Alpha amylase, catalytic domain
PF00072 (9/9) Response regulator receiver domain
precursor_groups_78435 314.71 +- 56.71 2 0 2 0 0.01 +- 0.01 2 6

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08924 (2/2) Domain of unknown function (DUF1906)
PF06737 (2/2) Transglycosylase-like domain
PF01839 (2/2) FG-GAP repeat
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00293 (1/2) NUDIX domain
precursor_groups_37942 245.78 +- 157.19 3 0 0 0 0.08 +- 0.16 3 22

TIGR01552 (3/3) prevent-host-death family protein
TIGR00663 (3/3) DNA polymerase III, beta subunit
PF08031 (3/3) Berberine and berberine like
PF07690 (3/3) Major Facilitator Superfamily
PF05016 (3/3) ParE toxin of type II toxin-antitoxin system, parDE
PF04073 (3/3) Aminoacyl-tRNA editing domain
PF02768 (3/3) DNA polymerase III beta subunit, C-terminal domain
PF02767 (3/3) DNA polymerase III beta subunit, central domain
PF02604 (3/3) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02274 (3/3) Amidinotransferase
PF01565 (3/3) FAD binding domain
PF00712 (3/3) DNA polymerase III beta subunit, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
TIGR00348 (2/3) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/3) SWI2/SNF2 ATPase
PF13476 (2/3) AAA domain
PF13304 (2/3) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (2/3) HsdM N-terminal domain
PF11867 (2/3) Domain of unknown function (DUF3387)
PF04313 (2/3) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/3) N-6 DNA Methylase
PF01420 (2/3) Type I restriction modification DNA specificity domain
precursor_groups_1159 12.43 +- 0.47 2 0 0 0 0.16 +- 0.14 2 6

PF11695 (2/2) Domain of unknown function (DUF3291)
TIGR01764 (1/2) DNA binding domain, excisionase family
PF12728 (1/2) Helix-turn-helix domain
PF12697 (1/2) Alpha/beta hydrolase family
PF00069 (1/2) Protein kinase domain
PF00067 (1/2) Cytochrome P450
precursor_groups_7589 140.36 +- 95.37 6 0 0 0 0.13 +- 0.26 6 10

TIGR01727 (6/6) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01266 (6/6) fumarylacetoacetase
PF12911 (6/6) N-terminal TM domain of oligopeptide transport permease C
PF09298 (6/6) Fumarylacetoacetase N-terminal
PF08352 (6/6) Oligopeptide/dipeptide transporter, C-terminal region
PF04209 (6/6) homogentisate 1,2-dioxygenase
PF01557 (6/6) Fumarylacetoacetate (FAA) hydrolase family
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00496 (6/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (6/6) ABC transporter
precursor_groups_66696 552.65 +- 97.35 2 0 0 0 0.03 +- 0.05 2 11

TIGR03211 (2/2) catechol 2,3 dioxygenase
PF09084 (2/2) NMT1/THI5 like
PF07690 (2/2) Major Facilitator Superfamily
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_3028 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
precursor_groups_55244 65.49 +- 10.34 2 0 0 0 0.19 +- 0.20 2 5

PF14273 (2/2) Domain of unknown function (DUF4360)
PF14016 (2/2) Protein of unknown function (DUF4232)
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01925 (2/2) Sulfite exporter TauE/SafE
precursor_groups_3756 23.96 +- 15.47 5 0 0 0 0.18 +- 0.16 5 4

PF16157 (5/5) Domain of unknown function (DUF4865)
PF02126 (5/5) Phosphotriesterase family
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF07883 (4/5) Cupin domain
precursor_groups_30422 39.31 +- 0.08 2 0 0 0 0.13 +- 0.22 2 9

PF10009 (2/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF02687 (2/2) FtsX-like permease family
PF01063 (2/2) Amino-transferase class IV
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
precursor_groups_71404 26.07 +- 1.02 2 0 0 0 0.15 +- 0.15 2 7

TIGR01048 (2/2) diaminopimelate decarboxylase
TIGR00247 (2/2) conserved hypothetical protein, YceG family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02618 (2/2) YceG-like family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_7584 556.45 +- 133.83 7 0 2 0 0.03 +- 0.15 7 7

PF17914 (7/7) HopA1 effector protein family
PF02441 (7/7) Flavoprotein
PF01636 (7/7) Phosphotransferase enzyme family
PF00296 (7/7) Luciferase-like monooxygenase
PF00005 (5/7) ABC transporter
PF02897 (4/7) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (4/7) Prolyl oligopeptidase family
precursor_groups_6471 670.50 +- 103.50 2 0 0 0 0.04 +- 0.04 2 7

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF01850 (2/2) PIN domain
PF00361 (2/2) Proton-conducting membrane transporter
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00146 (1/2) NADH dehydrogenase
precursor_groups_68592 323.00 +- 193.00 2 0 0 0 0.05 +- 0.07 2 5

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (2/2) MDMPI C-terminal domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04672 (1/2) S-adenosyl methyltransferase
precursor_groups_6474 54.68 +- 39.14 2 0 0 0 0.14 +- 0.24 2 11

TIGR03718 (1/2) integral membrane protein, TerC family
TIGR02891 (1/2) cytochrome c oxidase, subunit I
PF12270 (1/2) Cytochrome c oxidase subunit IV
PF03965 (1/2) Penicillinase repressor
PF03741 (1/2) Integral membrane protein TerC family
PF02515 (1/2) CoA-transferase family III
PF01435 (1/2) Peptidase family M48
PF01297 (1/2) Zinc-uptake complex component A periplasmic
PF00950 (1/2) ABC 3 transport family
PF00877 (1/2) NlpC/P60 family
PF00115 (1/2) Cytochrome C and Quinol oxidase polypeptide I
precursor_groups_68599 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_12721 277.10 +- 11.81 3 0 0 0 0.09 +- 0.15 3 3

PF01425 (3/3) Amidase
PF13340 (2/3) Putative transposase of IS4/5 family (DUF4096)
PF00378 (2/3) Enoyl-CoA hydratase/isomerase
precursor_groups_31418 68.11 +- 7.93 3 0 3 0 0.19 +- 0.30 3 20

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (3/3) amino acid adenylation domain
TIGR01327 (3/3) phosphoglycerate dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF05977 (3/3) Transmembrane secretion effector
PF04073 (3/3) Aminoacyl-tRNA editing domain
PF03176 (3/3) MMPL family
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01022 (3/3) Bacterial regulatory protein, arsR family
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (3/3) Beta-lactamase
precursor_groups_69379 635.18 +- 36.82 2 0 2 0 0.08 +- 0.22 2 17

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (2/2) Beta-lactamase superfamily domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03621 (2/2) MbtH-like protein
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (2/2) ParB-like nuclease domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
precursor_groups_67921 142.34 +- 115.66 2 0 2 0 0.04 +- 0.05 2 2

PF11806 (2/2) Domain of unknown function (DUF3327)
PF00756 (2/2) Putative esterase
precursor_groups_65315 713.00 +- 197.00 2 0 0 2 0.01 +- 0.00 2 10

TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13238 (2/2) AAA domain
PF04055 (2/2) Radical SAM superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_68754 381.16 +- 102.59 2 0 0 0 0.02 +- 0.02 2 4

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_groups_23954 666.50 +- 508.70 3 0 3 0 0.04 +- 0.12 3 12

TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_16088 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_groups_16089 158.14 +- 170.69 6 0 6 0 0.11 +- 0.20 6 6

PF08484 (6/6) C-methyltransferase C-terminal domain
PF08421 (6/6) Putative zinc binding domain
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF01061 (6/6) ABC-2 type transporter
PF00908 (6/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00005 (6/6) ABC transporter
precursor_groups_22138 163.22 +- 148.78 2 0 0 0 0.11 +- 0.26 2 4

TIGR00813 (2/2) transporter, solute:sodium symporter (SSS) family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00485 (2/2) Phosphoribulokinase / Uridine kinase family
PF00474 (2/2) Sodium:solute symporter family
precursor_groups_82645 322.50 +- 223.27 2 0 2 0 0.06 +- 0.21 2 18

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01035 (2/2) glutamyl-tRNA reductase
PF17645 (2/2) Arylmalonate decarboxylase
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13549 (2/2) ATP-grasp domain
PF13380 (2/2) CoA binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF05201 (2/2) Glutamyl-tRNAGlu reductase, N-terminal domain
PF03795 (2/2) YCII-related domain
PF03466 (2/2) LysR substrate binding domain
PF01494 (2/2) FAD binding domain
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00892 (2/2) EamA-like transporter family
PF00745 (2/2) Glutamyl-tRNAGlu reductase, dimerisation domain
PF00490 (2/2) Delta-aminolevulinic acid dehydratase
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_45962 146.25 +- 113.75 2 0 0 0 0.03 +- 0.05 2 2

PF10056 (2/2) Uncharacterized conserved protein (DUF2293)
PF08592 (2/2) Domain of unknown function (DUF1772)
precursor_groups_78723 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_3330 330.05 +- 259.77 14 0 0 13 0.04 +- 0.06 14 7

TIGR03882 (13/14) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/14) thiazole/oxazole-forming peptide maturase, SagD family component
PF06738 (13/14) Putative threonine/serine exporter
PF02624 (13/14) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (13/14) Nitroreductase family
PF00664 (13/14) ABC transporter transmembrane region
PF00005 (13/14) ABC transporter
precursor_groups_60591 618.82 +- 525.18 2 0 2 0 0.06 +- 0.20 2 21

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01553 (2/2) Acyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00975 (2/2) Thioesterase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01575 (1/2) MaoC like domain
precursor_groups_12463 50.00 +- 13.87 8 0 0 0 0.13 +- 0.09 8 5

PF07729 (8/8) FCD domain
PF03067 (8/8) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (8/8) Glycosyl hydrolase family 12
PF00553 (8/8) Cellulose binding domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
precursor_groups_23391 69.35 +- 20.90 5 0 5 0 0.06 +- 0.05 5 10

TIGR01613 (5/5) phage/plasmid primase, P4 family, C-terminal domain
TIGR00778 (5/5) alkylhydroperoxidase AhpD family core domain
PF13454 (5/5) FAD-NAD(P)-binding
PF09250 (5/5) Bifunctional DNA primase/polymerase, N-terminal
PF08706 (5/5) D5 N terminal like
PF03288 (5/5) Poxvirus D5 protein-like
PF02896 (5/5) PEP-utilising enzyme, TIM barrel domain
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00391 (5/5) PEP-utilising enzyme, mobile domain
PF01717 (4/5) Cobalamin-independent synthase, Catalytic domain
precursor_groups_54202 181.87 +- 22.82 2 0 0 0 0.18 +- 0.23 2 17

TIGR03356 (2/2) beta-galactosidase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF02983 (2/2) Alpha-lytic protease prodomain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00005 (2/2) ABC transporter
PF03160 (1/2) Calx-beta domain
PF00089 (1/2) Trypsin
precursor_groups_69979 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_groups_29832 497.39 +- 308.50 3 0 3 0 0.03 +- 0.04 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_22555 606.68 +- 103.68 5 0 1 0 0.01 +- 0.01 5 6

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
precursor_groups_71121 325.00 +- 65.00 2 0 2 2 0.01 +- 0.00 2 5

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00067 (1/2) Cytochrome P450
precursor_groups_71122 133.90 +- 28.60 2 0 0 0 0.06 +- 0.07 2 4

PF13309 (2/2) HTH domain
PF08348 (2/2) YheO-like PAS domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_6699 18.80 +- 4.95 3 0 0 0 0.11 +- 0.12 3 5

PF13489 (3/3) Methyltransferase domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
PF00204 (3/3) DNA gyrase B
precursor_groups_7053 190.08 +- 61.70 7 0 7 7 0.01 +- 0.00 7 4

TIGR03891 (7/7) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF05147 (7/7) Lanthionine synthetase C-like protein
PF04738 (7/7) Lantibiotic dehydratase, N terminus
precursor_groups_67816 20.83 +- 0.83 2 0 0 0 0.19 +- 0.14 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF00144 (2/2) Beta-lactamase
PF00041 (2/2) Fibronectin type III domain
precursor_groups_26632 305.62 +- 233.24 3 0 3 0 0.03 +- 0.04 3 9

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF08659 (3/3) KR domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_7058 33.73 +- 9.33 8 0 8 0 0.21 +- 0.20 8 8

PF11991 (8/8) Tryptophan dimethylallyltransferase
PF05331 (8/8) Protein of unknown function (DUF742)
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF02518 (8/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (8/8) Beta-eliminating lyase
PF00664 (8/8) ABC transporter transmembrane region
PF00005 (8/8) ABC transporter
precursor_groups_6693 382.39 +- 158.19 4 0 0 0 0.04 +- 0.01 4 5

PF13407 (4/4) Periplasmic binding protein domain
PF02653 (4/4) Branched-chain amino acid transport system / permease component
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF00005 (4/4) ABC transporter
precursor_groups_290 43.63 +- 45.33 3 0 0 0 0.20 +- 0.23 3 8

PF12728 (3/3) Helix-turn-helix domain
PF10935 (3/3) Protein of unknown function (DUF2637)
PF05122 (3/3) Mobile element transfer protein
PF01580 (3/3) FtsK/SpoIIIE family
PF00589 (3/3) Phage integrase family
TIGR01764 (2/3) DNA binding domain, excisionase family
PF07702 (2/3) UTRA domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_groups_64853 92.55 +- 24.72 2 0 2 0 0.05 +- 0.03 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08241 (2/2) Methyltransferase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
precursor_groups_64854 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_4414 84.93 +- 58.51 3 0 0 0 0.16 +- 0.17 3 9

TIGR00996 (3/3) virulence factor Mce family protein
PF13814 (3/3) Replication-relaxation
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
precursor_groups_73621 147.49 +- 19.43 2 0 0 2 0.17 +- 0.22 2 20

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (2/2) formate acetyltransferase
TIGR00886 (2/2) nitrite transporter
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01228 (2/2) Glycine radical
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
TIGR02374 (1/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (1/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (1/2) Rieske-like [2Fe-2S] domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF03460 (1/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (1/2) Nitrite and sulphite reductase 4Fe-4S domain
precursor_groups_16885 35.11 +- 9.73 6 0 0 0 0.12 +- 0.16 6 4

PF07690 (6/6) Major Facilitator Superfamily
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (6/6) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (6/6) Acetyltransferase (GNAT) family
precursor_groups_83749 419.50 +- 204.50 2 0 0 0 0.02 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
PF13546 (1/2) DDE superfamily endonuclease
precursor_groups_49495 192.31 +- 70.43 2 0 0 0 0.08 +- 0.07 2 11

PF13407 (2/2) Periplasmic binding protein domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02610 (2/2) L-arabinose isomerase
PF00005 (2/2) ABC transporter
TIGR01234 (1/2) ribulokinase
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01263 (1/2) Aldose 1-epimerase
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
precursor_groups_77189 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_13328 1428.62 +- 998.05 7 0 7 0 0.02 +- 0.07 7 11

PF13622 (7/7) Thioesterase-like superfamily
PF07690 (7/7) Major Facilitator Superfamily
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00487 (7/7) Fatty acid desaturase
PF00301 (7/7) Rubredoxin
PF00067 (7/7) Cytochrome P450
PF12679 (5/7) ABC-2 family transporter protein
PF00005 (5/7) ABC transporter
PF12146 (4/7) Serine aminopeptidase, S33
PF00392 (4/7) Bacterial regulatory proteins, gntR family
precursor_groups_3246 85.03 +- 2.59 2 0 0 0 0.20 +- 0.27 2 14

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13378 (2/2) Enolase C-terminal domain-like
PF09723 (2/2) Zinc ribbon domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00802 (1/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF03824 (1/2) High-affinity nickel-transport protein
precursor_groups_58843 870.07 +- 299.53 2 0 2 0 0.04 +- 0.03 2 25

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13187 (2/2) 4Fe-4S dicluster domain
PF08659 (2/2) KR domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (2/2) Major Facilitator Superfamily
PF04432 (2/2) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (2/2) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (2/2) FMN-dependent dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_58332 181.00 +- 77.00 2 0 0 0 0.01 +- 0.01 2 2

PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_10496 2014.89 +- 824.36 9 0 1 0 0.01 +- 0.01 9 12

PF13560 (9/9) Helix-turn-helix domain
PF13393 (9/9) Histidyl-tRNA synthetase
PF03721 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01370 (9/9) NAD dependent epimerase/dehydratase family
PF01061 (9/9) ABC-2 type transporter
PF00984 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00005 (9/9) ABC transporter
PF17874 (8/9) MalT-like TPR region
PF05193 (8/9) Peptidase M16 inactive domain
PF00675 (8/9) Insulinase (Peptidase family M16)
precursor_groups_36734 518.00 +- 181.02 3 0 3 0 0.01 +- 0.00 3 3

PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01613 (3/3) Flavin reductase like domain
precursor_groups_61775 1203.43 +- 200.57 2 0 0 0 0.02 +- 0.02 2 6

PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_21556 832.00 +- 254.75 5 0 0 5 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02441 (5/5) Flavoprotein
precursor_groups_22952 226.48 +- 96.16 5 0 0 0 0.01 +- 0.01 5 3

TIGR01426 (5/5) glycosyltransferase, MGT family
PF03372 (5/5) Endonuclease/Exonuclease/phosphatase family
PF00201 (5/5) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_11384 74.03 +- 22.04 3 0 0 0 0.05 +- 0.07 3 9

PF13091 (3/3) PLD-like domain
PF03176 (3/3) MMPL family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01569 (3/3) PAP2 superfamily
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00144 (3/3) Beta-lactamase
PF00072 (3/3) Response regulator receiver domain
precursor_groups_11380 77.74 +- 21.24 7 0 0 0 0.03 +- 0.04 7 6

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (7/7) FAD binding domain
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
PF13669 (4/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_65339 40.50 +- 1.11 2 0 2 0 0.22 +- 0.35 2 15

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03061 (2/2) Thioesterase superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_7125 75.72 +- 40.35 4 0 0 0 0.05 +- 0.05 4 1

PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_7126 110.00 +- 19.00 2 0 0 0 0.21 +- 0.28 2 17

PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00594 (1/2) DNA polymerase III, alpha subunit
PF17657 (1/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (1/2) Helix-hairpin-helix motif
PF11799 (1/2) impB/mucB/samB family C-terminal domain
PF07733 (1/2) Bacterial DNA polymerase III alpha NTPase domain
PF02811 (1/2) PHP domain
PF01145 (1/2) SPFH domain / Band 7 family
PF00817 (1/2) impB/mucB/samB family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
precursor_groups_16868 1399.34 +- 29.58 2 0 2 2 0.02 +- 0.02 2 7

PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF15567 (2/2) Immunity protein 35
PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (2/2) Peptidase family M20/M25/M40
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
precursor_groups_47322 20.32 +- 2.96 3 0 1 0 0.15 +- 0.06 3 4

TIGR00791 (3/3) transporter, gluconate:H+ symporter (GntP) family
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02447 (3/3) GntP family permease
precursor_groups_69152 118.89 +- 102.25 2 0 2 0 0.06 +- 0.18 2 4

PF17195 (2/2) Protein of unknown function (DUF5132)
PF12697 (2/2) Alpha/beta hydrolase family
PF05960 (2/2) Bacterial protein of unknown function (DUF885)
PF00975 (2/2) Thioesterase domain
precursor_groups_14931 285.71 +- 10.10 3 0 3 3 0.02 +- 0.00 3 5

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07690 (3/3) Major Facilitator Superfamily
PF00881 (3/3) Nitroreductase family
precursor_groups_26701 94.87 +- 115.35 3 0 0 0 0.10 +- 0.11 3 3

PF07702 (3/3) UTRA domain
PF04672 (3/3) S-adenosyl methyltransferase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_34356 108.44 +- 22.50 2 0 0 0 0.09 +- 0.14 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00893 (2/2) Small Multidrug Resistance protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_80912 1334.20 +- 95.80 2 0 0 0 0.02 +- 0.01 2 9

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF12698 (2/2) ABC-2 family transporter protein
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13732 (1/2) Domain of unknown function (DUF4162)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_20603 2728.16 +- 778.76 5 0 5 0 0.01 +- 0.01 5 16

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
PF13649 (5/5) Methyltransferase domain
PF13560 (5/5) Helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07993 (5/5) Male sterility protein
PF00977 (5/5) Histidine biosynthesis protein
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00107 (5/5) Zinc-binding dehydrogenase
PF13304 (4/5) AAA domain, putative AbiEii toxin, Type IV TA system
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00005 (4/5) ABC transporter
precursor_groups_69159 294.61 +- 0.00 2 0 2 0 0.04 +- 0.10 2 16

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02254 (2/2) TrkA-N domain
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01323 (2/2) DSBA-like thioredoxin domain
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_groups_34604 327.90 +- 26.85 2 0 2 2 0.01 +- 0.01 2 11

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF14518 (2/2) Iron-containing redox enzyme
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01048 (2/2) Phosphorylase superfamily
precursor_groups_34600 110.30 +- 63.03 2 0 0 0 0.03 +- 0.02 2 5

PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
precursor_groups_31806 757.17 +- 285.55 3 0 3 0 0.01 +- 0.00 3 11

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02566 (3/3) OsmC-like protein
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_groups_21458 157.94 +- 73.03 5 0 0 0 0.05 +- 0.04 5 8

PF14864 (5/5) Alkyl sulfatase C-terminal
PF14863 (5/5) Alkyl sulfatase dimerisation
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_9504 116.33 +- 15.55 9 0 0 0 0.08 +- 0.19 9 13

PF14117 (9/9) Domain of unknown function (DUF4287)
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF06197 (9/9) Protein of unknown function (DUF998)
PF02771 (9/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF01979 (9/9) Amidohydrolase family
PF01575 (9/9) MaoC like domain
PF00501 (9/9) AMP-binding enzyme
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (9/9) Aminotransferase class I and II
PF00132 (9/9) Bacterial transferase hexapeptide (six repeats)
precursor_groups_38877 218.94 +- 121.49 3 0 3 0 0.04 +- 0.02 3 16

TIGR03947 (3/3) capreomycidine synthase
TIGR03946 (3/3) arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependent
TIGR01733 (3/3) amino acid adenylation domain
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00535 (3/3) Glycosyl transferase family 2
PF00501 (3/3) AMP-binding enzyme
PF00155 (3/3) Aminotransferase class I and II
PF01370 (2/3) NAD dependent epimerase/dehydratase family
PF00583 (2/3) Acetyltransferase (GNAT) family
precursor_groups_27623 60.11 +- 9.38 4 0 0 0 0.07 +- 0.05 4 12

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18130 (4/4) ATP-grasp N-terminal domain
PF17802 (4/4) Prealbumin-like fold domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF01555 (4/4) DNA methylase
PF01068 (4/4) ATP dependent DNA ligase domain
precursor_groups_11943 318.16 +- 71.84 2 0 2 0 0.03 +- 0.03 2 10

TIGR01733 (2/2) amino acid adenylation domain
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_66516 135.74 +- 37.59 2 0 0 0 0.04 +- 0.03 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF01596 (2/2) O-methyltransferase
PF01402 (2/2) Ribbon-helix-helix protein, copG family
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00072 (2/2) Response regulator receiver domain
TIGR00027 (1/2) methyltransferase, TIGR00027 family
PF04072 (1/2) Leucine carboxyl methyltransferase
precursor_groups_751 114.45 +- 68.58 11 0 0 0 0.11 +- 0.27 11 2

PF02600 (11/11) Disulfide bond formation protein DsbB
PF03807 (7/11) NADP oxidoreductase coenzyme F420-dependent
precursor_groups_1264 324.00 +- 66.00 2 0 0 0 0.01 +- 0.00 2 3

PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_45293 553.90 +- 184.40 3 0 0 0 0.03 +- 0.02 3 12

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12833 (3/3) Helix-turn-helix domain
PF12625 (3/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06821 (3/3) Serine hydrolase
PF05853 (3/3) beta-keto acid cleavage enzyme
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (3/3) AMP-binding enzyme
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_45295 355.55 +- 289.45 2 0 0 0 0.05 +- 0.11 2 5

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF12802 (2/2) MarR family
PF07859 (2/2) alpha/beta hydrolase fold
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_71872 19.83 +- 2.27 2 0 0 0 0.20 +- 0.36 2 7

TIGR00754 (2/2) bacterioferritin
PF09130 (2/2) Domain of unknown function (DUF1932)
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF00210 (2/2) Ferritin-like domain
PF10400 (1/2) Virulence activator alpha C-term
PF08922 (1/2) Domain of unknown function (DUF1905)
PF03551 (1/2) Transcriptional regulator PadR-like family
precursor_groups_29764 107.92 +- 55.70 3 0 0 0 0.06 +- 0.05 3 4

PF13377 (3/3) Periplasmic binding protein-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF01301 (3/3) Glycosyl hydrolases family 35
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_35881 28.09 +- 0.23 2 0 0 0 0.11 +- 0.12 2 6

PF13183 (2/2) 4Fe-4S dicluster domain
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01565 (2/2) FAD binding domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_4588 73.41 +- 64.19 2 0 0 0 0.13 +- 0.16 2 11

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (2/2) Cytochrome P450
TIGR00765 (1/2) YihY family inner membrane protein
PF14019 (1/2) Protein of unknown function (DUF4235)
PF13810 (1/2) Domain of unknown function (DUF4185)
PF12277 (1/2) Protein of unknown function (DUF3618)
PF07332 (1/2) Putative Actinobacterial Holin-X, holin superfamily III
PF03631 (1/2) Virulence factor BrkB
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01569 (1/2) PAP2 superfamily
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_57593 1632.40 +- 187.60 2 0 2 2 0.01 +- 0.00 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_30053 38.82 +- 4.76 4 0 0 0 0.06 +- 0.04 4 1

PF03771 (4/4) Domain of unknown function (DUF317)
precursor_groups_45105 1062.71 +- 71.11 3 0 3 0 0.01 +- 0.00 3 21

TIGR04170 (3/3) ribonucleoside-diphosphate reductase, class 1b, alpha subunit
PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF08343 (3/3) Ribonucleotide reductase N-terminal
PF05977 (3/3) Transmembrane secretion effector
PF04167 (3/3) Protein of unknown function (DUF402)
PF02867 (3/3) Ribonucleotide reductase, barrel domain
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00857 (3/3) Isochorismatase family
PF00317 (3/3) Ribonucleotide reductase, all-alpha domain
TIGR04171 (2/3) ribonucleoside-diphosphate reductase, class 1b, beta subunit
TIGR02124 (2/3) hydrogenase expression/formation protein HypE
TIGR00143 (2/3) carbamoyltransferase HypF
PF17788 (2/3) HypF Kae1-like domain
PF07690 (2/3) Major Facilitator Superfamily
PF07503 (2/3) HypF finger
PF02769 (2/3) AIR synthase related protein, C-terminal domain
PF01408 (2/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01300 (2/3) Telomere recombination
PF00708 (2/3) Acylphosphatase
PF00586 (2/3) AIR synthase related protein, N-terminal domain
PF00268 (2/3) Ribonucleotide reductase, small chain
precursor_groups_48679 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_4581 262.75 +- 598.03 14 0 0 14 0.09 +- 0.26 14 7

PF14518 (14/14) Iron-containing redox enzyme
PF04055 (14/14) Radical SAM superfamily
PF03704 (13/14) Bacterial transcriptional activator domain
PF02687 (12/14) FtsX-like permease family
PF00486 (12/14) Transcriptional regulatory protein, C terminal
PF00005 (12/14) ABC transporter
PF12704 (10/14) MacB-like periplasmic core domain
precursor_groups_79072 758.33 +- 411.67 2 0 0 2 0.03 +- 0.08 2 10

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08007 (2/2) Cupin superfamily protein
PF06182 (2/2) ABC-2 family transporter protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02373 (2/2) JmjC domain, hydroxylase
PF00491 (2/2) Arginase family
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
PF18029 (1/2) Glyoxalase-like domain
precursor_groups_1663 81.29 +- 50.04 43 0 0 0 0.07 +- 0.04 43 4

PF13738 (43/43) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (43/43) FMN-dependent dehydrogenase
PF00999 (43/43) Sodium/hydrogen exchanger family
PF00067 (43/43) Cytochrome P450
precursor_groups_40552 66.37 +- 10.89 3 0 0 0 0.17 +- 0.07 3 5

PF04909 (3/3) Amidohydrolase
PF04199 (3/3) Putative cyclase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_8477 39.81 +- 4.76 2 0 0 0 0.23 +- 0.33 2 11

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF07729 (2/2) FCD domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02777 (2/2) Iron/manganese superoxide dismutases, C-terminal domain
PF01839 (2/2) FG-GAP repeat
PF01636 (2/2) Phosphotransferase enzyme family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00081 (2/2) Iron/manganese superoxide dismutases, alpha-hairpin domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_11013 220.91 +- 66.73 9 0 0 0 0.05 +- 0.05 9 6

TIGR03930 (9/9) WXG100 family type VII secretion target
TIGR03921 (9/9) type VII secretion-associated serine protease mycosin
TIGR03919 (9/9) type VII secretion protein EccB
PF06013 (9/9) Proteins of 100 residues with WXG
PF05108 (9/9) Type VII secretion system ESX-1, transport TM domain B
PF00082 (9/9) Subtilase family
precursor_groups_11010 83.50 +- 14.90 4 0 0 0 0.21 +- 0.06 4 7

TIGR03860 (4/4) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (4/4) NMT1/THI5 like
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00480 (4/4) ROK family
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
precursor_groups_10546 144.33 +- 115.67 2 0 0 0 0.04 +- 0.05 2 2

PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_61081 473.57 +- 83.57 2 0 0 0 0.02 +- 0.01 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_10542 16.59 +- 1.41 3 0 0 0 0.18 +- 0.22 3 10

TIGR00630 (3/3) excinuclease ABC subunit A
PF17755 (3/3) UvrA DNA-binding domain
PF14759 (3/3) Reductase C-terminal
PF13499 (3/3) EF-hand domain pair
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07045 (3/3) Domain of unknown function (DUF1330)
PF04471 (3/3) Restriction endonuclease
PF02342 (3/3) TerD domain
PF00005 (3/3) ABC transporter
precursor_groups_33257 134.23 +- 12.02 2 0 2 0 0.03 +- 0.03 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03109 (2/2) ABC1 family
PF00487 (2/2) Fatty acid desaturase
precursor_groups_46923 1146.00 +- 338.46 3 0 0 0 0.01 +- 0.01 3 11

TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF14518 (3/3) Iron-containing redox enzyme
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00069 (3/3) Protein kinase domain
precursor_groups_79071 35.46 +- 0.40 2 0 0 0 0.11 +- 0.18 2 5

PF11239 (2/2) Protein of unknown function (DUF3040)
PF07690 (2/2) Major Facilitator Superfamily
PF04203 (2/2) Sortase domain
PF02610 (2/2) L-arabinose isomerase
PF00999 (2/2) Sodium/hydrogen exchanger family
precursor_groups_14006 102.27 +- 3.04 2 0 2 0 0.08 +- 0.03 2 14

PF16901 (2/2) C-terminal domain of alpha-glycerophosphate oxidase
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF04978 (2/2) Protein of unknown function (DUF664)
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
precursor_groups_51322 28.92 +- 7.25 2 0 0 0 0.15 +- 0.23 2 8

TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14404 (2/2) Ribosomally synthesized peptide in Streptomyces species
PF13449 (2/2) Esterase-like activity of phytase
PF12796 (2/2) Ankyrin repeats (3 copies)
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_72571 1956.02 +- 301.48 2 0 0 0 0.01 +- 0.00 2 6

PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02449 (2/2) Beta-galactosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_8346 24.89 +- 11.62 2 0 0 0 0.15 +- 0.17 2 5

TIGR03356 (2/2) beta-galactosidase
PF07690 (2/2) Major Facilitator Superfamily
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_21951 115.89 +- 85.45 4 0 0 0 0.06 +- 0.07 4 2

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF01872 (4/4) RibD C-terminal domain
precursor_groups_7835 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF06737 (2/2) Transglycosylase-like domain
PF05257 (2/2) CHAP domain
precursor_groups_23606 148.63 +- 64.84 5 0 0 0 0.12 +- 0.19 5 11

PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF05544 (5/5) Proline racemase
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF00005 (5/5) ABC transporter
PF13510 (4/5) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/5) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (4/5) BFD-like [2Fe-2S] binding domain
PF01266 (4/5) FAD dependent oxidoreductase
PF00701 (4/5) Dihydrodipicolinate synthetase family
precursor_groups_4699 464.29 +- 204.29 2 0 2 0 0.02 +- 0.01 2 8

TIGR00808 (2/2) malonate transporter, MadM subunit
TIGR00807 (2/2) malonate transporter, MadL subunit
PF17408 (2/2) Malonyl-CoA decarboxylase N-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05292 (2/2) Malonyl-CoA decarboxylase C-terminal domain
PF03818 (2/2) Malonate/sodium symporter MadM subunit
PF03817 (2/2) Malonate transporter MadL subunit
PF00501 (2/2) AMP-binding enzyme
precursor_groups_71908 6286.90 +- 4033.10 2 0 2 2 0.02 +- 0.07 2 21

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12698 (2/2) ABC-2 family transporter protein
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_1405 29.54 +- 15.29 6 0 4 0 0.13 +- 0.15 6 9

PF14361 (6/6) RsbT co-antagonist protein rsbRD N-terminal domain
PF13581 (6/6) Histidine kinase-like ATPase domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF06348 (6/6) Protein of unknown function (DUF1059)
PF04545 (6/6) Sigma-70, region 4
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (6/6) STAS domain
PF00512 (6/6) His Kinase A (phospho-acceptor) domain
PF00072 (6/6) Response regulator receiver domain
precursor_groups_4164 541.67 +- 151.67 2 0 2 0 0.02 +- 0.03 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01123 (2/2) branched-chain amino acid aminotransferase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03621 (2/2) MbtH-like protein
PF02310 (2/2) B12 binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01425 (2/2) Amidase
PF01063 (2/2) Amino-transferase class IV
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00152 (2/2) tRNA synthetases class II (D, K and N)
precursor_groups_1407 41.59 +- 6.30 3 0 0 3 0.12 +- 0.23 3 15

TIGR04339 (3/3) PQQ system protein
TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR03075 (3/3) PQQ-dependent dehydrogenase, methanol/ethanol family
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
TIGR02107 (3/3) coenzyme PQQ precursor peptide PqqA
TIGR00198 (3/3) catalase/peroxidase HPI
PF13360 (3/3) PQQ-like domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08042 (3/3) PqqA family
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04397 (3/3) LytTr DNA-binding domain
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
PF00141 (3/3) Peroxidase
precursor_groups_10943 77.43 +- 25.99 9 0 9 9 0.06 +- 0.07 9 5

PF13471 (9/9) Transglutaminase-like superfamily
PF05402 (9/9) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (9/9) Asparagine synthase
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
precursor_groups_5743 81.12 +- 35.01 11 0 0 0 0.18 +- 0.14 11 7

PF14498 (11/11) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (11/11) Bacterial extracellular solute-binding protein
PF08533 (11/11) Beta-galactosidase C-terminal domain
PF08532 (11/11) Beta-galactosidase trimerisation domain
PF02449 (11/11) Beta-galactosidase
PF01670 (11/11) Glycosyl hydrolase family 12
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
precursor_groups_5741 82.44 +- 33.64 6 0 6 0 0.19 +- 0.31 6 19

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF10604 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF07690 (6/6) Major Facilitator Superfamily
PF04673 (6/6) Polyketide synthesis cyclase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF01494 (6/6) FAD binding domain
PF01039 (6/6) Carboxyl transferase domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00106 (6/6) short chain dehydrogenase
PF13822 (5/6) Acyl-CoA carboxylase epsilon subunit
PF14027 (4/6) Questin oxidase-like
PF00364 (4/6) Biotin-requiring enzyme
PF07732 (3/6) Multicopper oxidase
PF07731 (3/6) Multicopper oxidase
PF02786 (3/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/6) Biotin carboxylase C-terminal domain
PF00394 (3/6) Multicopper oxidase
precursor_groups_67526 414.64 +- 27.64 2 0 0 0 0.01 +- 0.00 2 3

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase
precursor_groups_36198 44.75 +- 8.66 3 0 0 0 0.07 +- 0.04 3 6

PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_62683 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_39474 62.94 +- 7.17 3 0 0 0 0.16 +- 0.12 3 7

PF13601 (3/3) Winged helix DNA-binding domain
PF12698 (3/3) ABC-2 family transporter protein
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00135 (3/3) Carboxylesterase family
PF00005 (3/3) ABC transporter
PF01497 (2/3) Periplasmic binding protein
PF01032 (2/3) FecCD transport family
precursor_groups_62192 439.24 +- 91.93 2 0 0 0 0.02 +- 0.01 2 9

PF16884 (2/2) N-terminal domain of oxidoreductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_20800 50.71 +- 7.85 2 0 0 0 0.21 +- 0.25 2 24

PF09364 (2/2) XFP N-terminal domain
PF09363 (2/2) XFP C-terminal domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03894 (2/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00667 (2/2) FAD binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
TIGR03557 (1/2) F420-dependent oxidoreductase, G6PDH family
PF13535 (1/2) ATP-grasp domain
PF13244 (1/2) Domain of unknown function (DUF4040)
PF07690 (1/2) Major Facilitator Superfamily
PF06276 (1/2) Ferric iron reductase FhuF-like transporter
PF04183 (1/2) IucA / IucC family
PF04066 (1/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (1/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/2) Proton-conducting membrane transporter
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
precursor_groups_12687 24.90 +- 4.45 7 0 0 0 0.12 +- 0.10 7 3

PF04909 (7/7) Amidohydrolase
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF00248 (7/7) Aldo/keto reductase family
precursor_groups_51439 293.18 +- 35.18 2 0 0 0 0.01 +- 0.00 2 9

TIGR02170 (2/2) thymidylate synthase, flavin-dependent
TIGR00730 (2/2) TIGR00730 family protein
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (2/2) ATP-grasp domain
PF03641 (2/2) Possible lysine decarboxylase
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02511 (2/2) Thymidylate synthase complementing protein
PF00860 (2/2) Permease family
precursor_groups_30814 217.53 +- 93.33 4 0 0 0 0.09 +- 0.17 4 9

TIGR01726 (4/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01428 (4/4) haloacid dehalogenase, type II
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00497 (4/4) Bacterial extracellular solute-binding proteins, family 3
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
precursor_groups_41110 816.86 +- 486.69 3 0 0 0 0.03 +- 0.06 3 9

TIGR03168 (3/3) hexose kinase, 1-phosphofructokinase family
TIGR00167 (3/3) ketose-bisphosphate aldolase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01301 (3/3) Glycosyl hydrolases family 35
PF01116 (3/3) Fructose-bisphosphate aldolase class-II
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00480 (3/3) ROK family
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_groups_50126 157.48 +- 132.77 2 0 0 0 0.07 +- 0.13 2 4

TIGR03666 (2/2) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07690 (2/2) Major Facilitator Superfamily
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_36514 118.50 +- 53.50 2 0 2 0 0.02 +- 0.02 2 2

PF05990 (2/2) Alpha/beta hydrolase of unknown function (DUF900)
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_351 74.56 +- 86.65 9 0 1 0 0.06 +- 0.07 9 2

PF00171 (9/9) Aldehyde dehydrogenase family
PF00724 (8/9) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_353 581.06 +- 630.26 30 0 26 3 0.03 +- 0.08 30 6

PF13193 (27/30) AMP-binding enzyme C-terminal domain
PF00501 (27/30) AMP-binding enzyme
TIGR03892 (24/30) thiazolylpeptide-type bacteriocin precursor
PF01959 (24/30) 3-dehydroquinate synthase II
PF01791 (24/30) DeoC/LacD family aldolase
PF01494 (24/30) FAD binding domain
precursor_groups_17283 65.84 +- 31.58 2 0 0 0 0.20 +- 0.30 2 7

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF07884 (2/2) Vitamin K epoxide reductase family
PF03777 (2/2) ChpA-C
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF07987 (1/2) Domain of unkown function (DUF1775)
PF04542 (1/2) Sigma-70 region 2
precursor_groups_359 264.49 +- 553.92 9 0 5 1 0.12 +- 0.24 9 9

TIGR01733 (5/9) amino acid adenylation domain
TIGR01720 (5/9) non-ribosomal peptide synthase domain TIGR01720
PF13193 (5/9) AMP-binding enzyme C-terminal domain
PF03621 (5/9) MbtH-like protein
PF02274 (5/9) Amidinotransferase
PF00975 (5/9) Thioesterase domain
PF00668 (5/9) Condensation domain
PF00550 (5/9) Phosphopantetheine attachment site
PF00501 (5/9) AMP-binding enzyme
precursor_groups_358 82.90 +- 44.68 2 0 0 0 0.15 +- 0.22 2 13

PF13358 (2/2) DDE superfamily endonuclease
TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
TIGR03919 (1/2) type VII secretion protein EccB
PF13592 (1/2) Winged helix-turn helix
PF13551 (1/2) Winged helix-turn helix
PF13276 (1/2) HTH-like domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain
PF00082 (1/2) Subtilase family
PF00067 (1/2) Cytochrome P450
precursor_groups_3312 132.60 +- 55.87 3 0 0 0 0.09 +- 0.20 3 5

PF12728 (3/3) Helix-turn-helix domain
PF10935 (2/3) Protein of unknown function (DUF2637)
PF09250 (2/3) Bifunctional DNA primase/polymerase, N-terminal
PF00589 (2/3) Phage integrase family
PF00293 (2/3) NUDIX domain
precursor_groups_1310 60.98 +- 18.63 18 0 0 0 0.19 +- 0.31 18 10

TIGR03177 (18/18) Flp pilus assembly protein CpaB
PF16976 (18/18) Flp pilus assembly protein RcpC/CpaB
PF07811 (18/18) TadE-like protein
PF00482 (18/18) Type II secretion system (T2SS), protein F
PF00437 (18/18) Type II/IV secretion system protein
PF13614 (17/18) AAA domain
PF07730 (14/18) Histidine kinase
PF00196 (14/18) Bacterial regulatory proteins, luxR family
PF00072 (14/18) Response regulator receiver domain
PF00691 (13/18) OmpA family
precursor_groups_64456 348.30 +- 38.70 2 0 2 0 0.01 +- 0.00 2 3

PF06339 (2/2) Ectoine synthase
PF01425 (2/2) Amidase
PF00668 (2/2) Condensation domain
precursor_groups_16403 59.95 +- 15.55 5 0 0 0 0.18 +- 0.14 5 7

PF14498 (5/5) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (5/5) Bacterial extracellular solute-binding protein
PF08533 (5/5) Beta-galactosidase C-terminal domain
PF08532 (5/5) Beta-galactosidase trimerisation domain
PF02449 (5/5) Beta-galactosidase
PF01670 (5/5) Glycosyl hydrolase family 12
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
precursor_groups_31252 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
precursor_groups_14536 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF13185 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_46454 138.08 +- 52.89 3 0 3 0 0.10 +- 0.26 3 19

TIGR03026 (3/3) nucleotide sugar dehydrogenase
TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF07730 (3/3) Histidine kinase
PF07690 (3/3) Major Facilitator Superfamily
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF01266 (3/3) FAD dependent oxidoreductase
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF08990 (2/3) Erythronolide synthase docking
precursor_groups_3287 76.99 +- 36.20 11 0 9 0 0.19 +- 0.13 11 11

PF13385 (11/11) Concanavalin A-like lectin/glucanases superfamily
PF08386 (11/11) TAP-like protein
PF07691 (11/11) PA14 domain
PF02837 (11/11) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (11/11) Glycosyl hydrolases family 2
PF00561 (11/11) alpha/beta hydrolase fold
PF13407 (10/11) Periplasmic binding protein domain
PF02653 (10/11) Branched-chain amino acid transport system / permease component
PF00005 (10/11) ABC transporter
PF13377 (9/11) Periplasmic binding protein-like domain
PF00356 (9/11) Bacterial regulatory proteins, lacI family
precursor_groups_41338 790.12 +- 159.63 3 0 3 0 0.01 +- 0.01 3 11

TIGR01490 (3/3) HAD hydrolase, family IB
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF05655 (3/3) Pseudomonas avirulence D protein (AvrD)
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00975 (3/3) Thioesterase domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_31093 371.43 +- 148.57 2 0 0 0 0.02 +- 0.03 2 8

TIGR03168 (2/2) hexose kinase, 1-phosphofructokinase family
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00167 (1/2) ketose-bisphosphate aldolase
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
precursor_groups_33102 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_36463 923.66 +- 883.19 3 0 3 0 0.06 +- 0.17 3 13

PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01746 (2/3) thioester reductase domain
TIGR01733 (2/3) amino acid adenylation domain
TIGR01720 (2/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF07993 (2/3) Male sterility protein
PF03621 (2/3) MbtH-like protein
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00202 (2/3) Aminotransferase class-III
precursor_groups_36467 18.76 +- 2.15 3 0 0 0 0.14 +- 0.18 3 6

TIGR02601 (3/3) autotransporter-associated beta strand repeat
PF12951 (3/3) Passenger-associated-transport-repeat
PF02366 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF01569 (3/3) PAP2 superfamily
PF01418 (3/3) Helix-turn-helix domain, rpiR family
PF01380 (2/3) SIS domain
precursor_groups_59520 22.15 +- 0.95 2 0 0 0 0.14 +- 0.16 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_groups_21738 18.77 +- 0.34 4 0 0 0 0.21 +- 0.39 4 12

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
TIGR00209 (4/4) galactose-1-phosphate uridylyltransferase
TIGR00131 (4/4) galactokinase
PF14099 (4/4) Polysaccharide lyase
PF10509 (4/4) Galactokinase galactose-binding signature
PF08544 (4/4) GHMP kinases C terminal
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF02744 (4/4) Galactose-1-phosphate uridyl transferase, C-terminal domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01087 (4/4) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF00455 (4/4) DeoR C terminal sensor domain
PF00288 (4/4) GHMP kinases N terminal domain
precursor_groups_37061 57.21 +- 7.97 2 0 0 0 0.10 +- 0.10 2 12

TIGR03217 (2/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/2) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (2/2) DmpG-like communication domain
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00296 (2/2) Luciferase-like monooxygenase
PF07690 (1/2) Major Facilitator Superfamily
PF00083 (1/2) Sugar (and other) transporter
precursor_groups_66337 137.60 +- 34.40 2 0 0 0 0.02 +- 0.01 2 3

PF13401 (2/2) AAA domain
PF08808 (2/2) RES domain
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_531 60.05 +- 25.20 13 0 0 0 0.07 +- 0.13 13 5

PF16259 (11/13) Domain of unknown function (DUF4913)
PF12696 (11/13) TraM recognition site of TraD and TraG
PF01425 (11/13) Amidase
PF02882 (7/13) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (7/13) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_1084 9.95 +- 1.74 3 0 2 0 0.21 +- 0.14 3 4

PF12697 (3/3) Alpha/beta hydrolase family
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02133 (3/3) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01070 (3/3) FMN-dependent dehydrogenase
precursor_groups_1087 66.59 +- 15.58 15 0 0 0 0.19 +- 0.19 15 7

TIGR03860 (15/15) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (15/15) NMT1/THI5 like
PF02668 (15/15) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF00480 (15/15) ROK family
PF00296 (15/15) Luciferase-like monooxygenase
PF00005 (15/15) ABC transporter
precursor_groups_47855 164.86 +- 47.86 2 0 0 0 0.04 +- 0.02 2 5

TIGR00784 (2/2) citrate transporter
PF18435 (2/2) Esterase Ig-like N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF03600 (2/2) Citrate transporter
PF00135 (2/2) Carboxylesterase family
precursor_groups_534 51.61 +- 18.47 9 0 0 0 0.16 +- 0.26 9 6

PF09594 (9/9) Glycosyltransferase family 87
PF03088 (9/9) Strictosidine synthase
PF12840 (8/9) Helix-turn-helix domain
PF07745 (7/9) Glycosyl hydrolase family 53
TIGR00494 (6/9) protein CrcB
PF02537 (6/9) CrcB-like protein, Camphor Resistance (CrcB)
precursor_groups_1083 76.14 +- 63.31 12 0 1 0 0.20 +- 0.26 12 8

PF00296 (12/12) Luciferase-like monooxygenase
PF13454 (11/12) FAD-NAD(P)-binding
TIGR03860 (10/12) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07920 (9/12) Protein of unknown function (DUF1684)
PF02983 (9/12) Alpha-lytic protease prodomain
PF00089 (9/12) Trypsin
PF00528 (6/12) Binding-protein-dependent transport system inner membrane component
PF00005 (6/12) ABC transporter
precursor_groups_56850 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_71616 195.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_25259 651.38 +- 451.61 3 0 0 0 0.02 +- 0.01 3 6

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF00581 (3/3) Rhodanese-like domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
precursor_groups_43159 32.88 +- 17.35 3 0 0 0 0.11 +- 0.11 3 7

PF18448 (3/3) Carbohydrate binding domain
PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF03442 (3/3) Carbohydrate binding domain X2
PF03330 (3/3) Lytic transglycolase
PF02065 (3/3) Melibiase
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_groups_2214 172.33 +- 85.67 2 0 0 0 0.02 +- 0.01 2 2

PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00920 (2/2) Dehydratase family
precursor_groups_5973 36.20 +- 4.24 2 0 0 0 0.20 +- 0.22 2 8

PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00027 (2/2) Cyclic nucleotide-binding domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
precursor_groups_85766 41.78 +- 18.92 2 0 0 0 0.12 +- 0.09 2 5

TIGR00504 (2/2) pyroglutamyl-peptidase I
PF11199 (2/2) Protein of unknown function (DUF2891)
PF06166 (2/2) Protein of unknown function (DUF979)
PF06149 (2/2) Protein of unknown function (DUF969)
PF01470 (2/2) Pyroglutamyl peptidase
precursor_groups_16719 141.10 +- 76.57 6 0 0 0 0.05 +- 0.04 6 8

PF14864 (6/6) Alkyl sulfatase C-terminal
PF14863 (6/6) Alkyl sulfatase dimerisation
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF00753 (6/6) Metallo-beta-lactamase superfamily
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_30470 138.01 +- 32.19 3 0 0 0 0.22 +- 0.32 3 11

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_30473 43.34 +- 13.14 2 0 0 0 0.18 +- 0.34 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF02687 (2/2) FtsX-like permease family
PF01526 (2/2) Tn3 transposase DDE domain
PF01494 (2/2) FAD binding domain
PF00005 (2/2) ABC transporter
PF13700 (1/2) Domain of unknown function (DUF4158)
precursor_groups_30472 29.05 +- 9.01 2 0 0 0 0.17 +- 0.33 2 5

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00082 (2/2) Subtilase family
PF05368 (1/2) NmrA-like family
PF01965 (1/2) DJ-1/PfpI family
precursor_groups_2190 16.19 +- 0.13 4 0 4 0 0.19 +- 0.30 4 4

PF10935 (4/4) Protein of unknown function (DUF2637)
PF05331 (4/4) Protein of unknown function (DUF742)
PF03259 (4/4) Roadblock/LC7 domain
PF03029 (4/4) Conserved hypothetical ATP binding protein
precursor_groups_73961 54.83 +- 10.17 2 0 2 0 0.06 +- 0.03 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_13151 20.13 +- 3.02 3 0 0 0 0.10 +- 0.09 3 2

PF13508 (3/3) Acetyltransferase (GNAT) domain
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_groups_85165 44.72 +- 0.49 2 0 0 0 0.13 +- 0.21 2 2

PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
precursor_groups_13156 30.65 +- 2.87 4 0 0 0 0.20 +- 0.25 4 7

PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF05544 (4/4) Proline racemase
PF04324 (4/4) BFD-like [2Fe-2S] binding domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01266 (4/4) FAD dependent oxidoreductase
PF00701 (4/4) Dihydrodipicolinate synthetase family
precursor_groups_2691 112.50 +- 22.18 2 0 0 0 0.19 +- 0.31 2 8

TIGR03445 (2/2) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF12698 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00005 (2/2) ABC transporter
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_60914 1750.00 +- 450.00 2 0 2 0 0.01 +- 0.00 2 13

TIGR02320 (2/2) phosphoenolpyruvate mutase
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01566 (2/2) Natural resistance-associated macrophage protein
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00202 (2/2) Aminotransferase class-III
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_228 37.01 +- 28.17 2 0 0 0 0.15 +- 0.29 2 15

TIGR00753 (1/2) undecaprenyl-diphosphatase UppP
PF13560 (1/2) Helix-turn-helix domain
PF08974 (1/2) Domain of unknown function (DUF1877)
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF02673 (1/2) Bacitracin resistance protein BacA
PF01638 (1/2) HxlR-like helix-turn-helix
PF01551 (1/2) Peptidase family M23
PF01494 (1/2) FAD binding domain
PF01297 (1/2) Zinc-uptake complex component A periplasmic
PF00950 (1/2) ABC 3 transport family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00271 (1/2) Helicase conserved C-terminal domain
PF00270 (1/2) DEAD/DEAH box helicase
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter
precursor_groups_60910 525.27 +- 248.73 2 0 0 0 0.02 +- 0.07 2 7

PF08241 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF13359 (1/2) DDE superfamily endonuclease
PF02585 (1/2) GlcNAc-PI de-N-acetylase
precursor_groups_224 243.58 +- 271.49 3 0 0 0 0.15 +- 0.15 3 4

PF07702 (3/3) UTRA domain
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF13546 (2/3) DDE superfamily endonuclease
PF00583 (2/3) Acetyltransferase (GNAT) family
precursor_groups_6137 650.17 +- 232.99 7 0 0 0 0.03 +- 0.02 7 7

PF17914 (7/7) HopA1 effector protein family
PF13649 (7/7) Methyltransferase domain
PF05193 (7/7) Peptidase M16 inactive domain
PF00675 (7/7) Insulinase (Peptidase family M16)
PF00296 (7/7) Luciferase-like monooxygenase
PF00005 (7/7) ABC transporter
PF02441 (6/7) Flavoprotein
precursor_groups_35565 588.49 +- 181.86 3 0 3 2 0.02 +- 0.02 3 17

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02195 (3/3) ParB-like nuclease domain
PF01266 (3/3) FAD dependent oxidoreductase
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/3) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/3) Glutamine amidotransferase domain
PF07690 (2/3) Major Facilitator Superfamily
PF00733 (2/3) Asparagine synthase
PF00067 (2/3) Cytochrome P450
precursor_groups_223 297.42 +- 278.10 5 0 1 1 0.07 +- 0.18 5

No common domains found
precursor_groups_21861 147.66 +- 61.72 5 0 1 0 0.15 +- 0.14 5 16

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13407 (5/5) Periplasmic binding protein domain
PF13378 (5/5) Enolase C-terminal domain-like
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07729 (5/5) FCD domain
PF05025 (5/5) RbsD / FucU transport protein family
PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF01081 (5/5) KDPG and KHG aldolase
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00248 (5/5) Aldo/keto reductase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter
TIGR01182 (4/5) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF04909 (4/5) Amidohydrolase
precursor_groups_71722 36.86 +- 0.44 2 0 0 0 0.16 +- 0.20 2 3

PF07519 (2/2) Tannase and feruloyl esterase
PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
precursor_groups_17629 120.24 +- 21.84 4 0 3 0 0.18 +- 0.13 4 11

PF13407 (4/4) Periplasmic binding protein domain
PF13385 (4/4) Concanavalin A-like lectin/glucanases superfamily
PF08386 (4/4) TAP-like protein
PF07691 (4/4) PA14 domain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02653 (4/4) Branched-chain amino acid transport system / permease component
PF00703 (4/4) Glycosyl hydrolases family 2
PF00561 (4/4) alpha/beta hydrolase fold
PF00005 (4/4) ABC transporter
PF13377 (3/4) Periplasmic binding protein-like domain
PF00356 (3/4) Bacterial regulatory proteins, lacI family
precursor_groups_79191 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_28177 48.50 +- 11.46 4 0 0 0 0.07 +- 0.07 4 6

PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (4/4) Alpha galactosidase A
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF04616 (3/4) Glycosyl hydrolases family 43
PF01794 (3/4) Ferric reductase like transmembrane component
PF00175 (3/4) Oxidoreductase NAD-binding domain
precursor_groups_24679 22.21 +- 3.79 2 0 0 0 0.14 +- 0.22 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_5566 126.97 +- 53.63 2 0 0 0 0.11 +- 0.22 2 19

TIGR02822 (1/2) zinc-binding alcohol dehydrogenase family protein
TIGR00223 (1/2) aspartate 1-decarboxylase
PF17871 (1/2) AAA lid domain
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF11139 (1/2) Sap, sulfolipid-1-addressing protein
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF06863 (1/2) Protein of unknown function (DUF1254)
PF06742 (1/2) Protein of unknown function (DUF1214)
PF06736 (1/2) Protein of unknown function (DUF1211)
PF05175 (1/2) Methyltransferase small domain
PF03631 (1/2) Virulence factor BrkB
PF02261 (1/2) Aspartate decarboxylase
PF01740 (1/2) STAS domain
PF00916 (1/2) Sulfate permease family
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00248 (1/2) Aldo/keto reductase family
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_28170 258.50 +- 0.87 4 0 0 0 0.01 +- 0.00 4 6

PF17390 (4/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (4/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (4/4) Alpha-L-rhamnosidase N-terminal domain
PF05592 (4/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00355 (4/4) Rieske [2Fe-2S] domain
precursor_groups_5565 207.93 +- 80.20 6 0 2 0 0.17 +- 0.26 6 11

PF11975 (6/6) Family 4 glycosyl hydrolase C-terminal domain
PF08376 (6/6) Nitrate and nitrite sensing
PF07690 (6/6) Major Facilitator Superfamily
PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02056 (6/6) Family 4 glycosyl hydrolase
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00294 (6/6) pfkB family carbohydrate kinase
PF03537 (4/6) Glycoside-hydrolase family GH114
precursor_groups_827 87.27 +- 75.23 2 0 1 0 0.13 +- 0.26 2 13

TIGR02246 (1/2) conserved hypothetical protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08332 (1/2) Calcium/calmodulin dependent protein kinase II association domain
PF07690 (1/2) Major Facilitator Superfamily
PF03702 (1/2) Anhydro-N-acetylmuramic acid kinase
PF00857 (1/2) Isochorismatase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00144 (1/2) Beta-lactamase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (1/2) Sugar (and other) transporter
PF00067 (1/2) Cytochrome P450
precursor_groups_16338 140.81 +- 51.87 5 0 4 0 0.08 +- 0.20 5 8

PF07690 (5/5) Major Facilitator Superfamily
TIGR01821 (4/5) 5-aminolevulinic acid synthase
PF16884 (4/5) N-terminal domain of oxidoreductase
PF08545 (4/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02668 (4/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (4/5) Aminotransferase class I and II
PF00107 (4/5) Zinc-binding dehydrogenase
precursor_groups_17724 24.39 +- 5.96 2 0 0 0 0.09 +- 0.11 2 5

TIGR00099 (2/2) Cof-like hydrolase
PF12161 (2/2) HsdM N-terminal domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_groups_27612 175.19 +- 59.86 4 0 0 0 0.06 +- 0.05 4 5

PF05426 (4/4) Alginate lyase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00295 (4/4) Glycosyl hydrolases family 28
TIGR01409 (3/4) Tat (twin-arginine translocation) pathway signal sequence
PF13416 (3/4) Bacterial extracellular solute-binding protein
precursor_groups_39461 362.20 +- 37.21 3 0 0 0 0.01 +- 0.00 3 6

PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02803 (3/3) Thiolase, C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00108 (3/3) Thiolase, N-terminal domain
precursor_groups_19004 47.18 +- 29.58 2 0 0 0 0.21 +- 0.24 2 29

TIGR03558 (1/2) luciferase family oxidoreductase, group 1
TIGR03086 (1/2) TIGR03086 family protein
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
TIGR01031 (1/2) ribosomal protein bL32
PF17874 (1/2) MalT-like TPR region
PF14100 (1/2) Methane oxygenase PmoA
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF12706 (1/2) Beta-lactamase superfamily domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08031 (1/2) Berberine and berberine like
PF07729 (1/2) FCD domain
PF07683 (1/2) Cobalamin synthesis protein cobW C-terminal domain
PF04616 (1/2) Glycosyl hydrolases family 43
PF04341 (1/2) Protein of unknown function, DUF485
PF02492 (1/2) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (1/2) Ribosomal L32p protein family
PF01565 (1/2) FAD binding domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01095 (1/2) Pectinesterase
PF00920 (1/2) Dehydratase family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00544 (1/2) Pectate lyase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00474 (1/2) Sodium:solute symporter family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_75777 1216.73 +- 96.73 2 0 0 0 0.01 +- 0.01 2 9

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF03466 (2/2) LysR substrate binding domain
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_18939 344.79 +- 140.15 5 0 0 0 0.03 +- 0.04 5 20

PF17853 (5/5) GGDEF-like domain
PF16483 (5/5) Beta-1,3-glucanase
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12077 (5/5) Transmembrane protein of unknown function (DUF3556)
PF06314 (5/5) Acetoacetate decarboxylase (ADC)
PF03466 (5/5) LysR substrate binding domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02737 (5/5) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (5/5) CoA-transferase family III
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00754 (5/5) F5/8 type C domain
PF00725 (5/5) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (5/5) Enoyl-CoA hydratase/isomerase
PF00324 (5/5) Amino acid permease
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_39464 292.40 +- 51.60 2 0 0 0 0.03 +- 0.04 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_71265 285.84 +- 53.64 2 0 0 0 0.03 +- 0.01 2 13

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13229 (2/2) Right handed beta helix region
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07745 (2/2) Glycosyl hydrolase family 53
PF07224 (2/2) Chlorophyllase
PF04616 (2/2) Glycosyl hydrolases family 43
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF02371 (1/2) Transposase IS116/IS110/IS902 family
PF01548 (1/2) Transposase
precursor_groups_22572 473.90 +- 383.28 4 0 4 0 0.06 +- 0.20 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13632 (4/4) Glycosyl transferase family group 2
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13191 (4/4) AAA ATPase domain
PF12710 (4/4) haloacid dehalogenase-like hydrolase
PF07690 (4/4) Major Facilitator Superfamily
PF04321 (4/4) RmlD substrate binding domain
PF01979 (4/4) Amidohydrolase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00459 (4/4) Inositol monophosphatase family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
TIGR00178 (3/4) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/4) Monomeric isocitrate dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_72961 278.28 +- 28.60 2 0 0 0 0.07 +- 0.05 2 12

PF13231 (2/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08757 (2/2) CotH kinase protein
PF04138 (2/2) GtrA-like protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00672 (2/2) HAMP domain
PF00535 (2/2) Glycosyl transferase family 2
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF16316 (1/2) Domain of unknown function (DUF4956)
PF09359 (1/2) VTC domain
precursor_groups_33818 117.78 +- 28.47 2 0 2 0 0.02 +- 0.02 2 6

PF18741 (2/2) REase_MTES_1575
PF13545 (2/2) Crp-like helix-turn-helix domain
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02342 (2/2) TerD domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_70050 145.65 +- 73.09 2 0 1 1 0.07 +- 0.11 2 17

PF00296 (2/2) Luciferase-like monooxygenase
TIGR01728 (1/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF18029 (1/2) Glyoxalase-like domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF09084 (1/2) NMT1/THI5 like
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02927 (1/2) Cellulase N-terminal ig-like domain
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02018 (1/2) Carbohydrate binding domain
PF01565 (1/2) FAD binding domain
PF01435 (1/2) Peptidase family M48
PF00881 (1/2) Nitroreductase family
PF00759 (1/2) Glycosyl hydrolase family 9
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
precursor_groups_53779 454.23 +- 0.00 2 0 2 0 0.11 +- 0.19 2 23

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01361 (2/2) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (2/2) DAHP synthase ferredoxin-like domain
PF13592 (2/2) Winged helix-turn helix
PF13551 (2/2) Winged helix-turn helix
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13191 (2/2) AAA ATPase domain
PF08242 (2/2) Methyltransferase domain
PF04820 (2/2) Tryptophan halogenase
PF03621 (2/2) MbtH-like protein
PF02195 (2/2) ParB-like nuclease domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00793 (2/2) DAHP synthetase I family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_75576 326.89 +- 3.11 2 0 0 0 0.11 +- 0.27 2 12

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13088 (2/2) BNR repeat-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02446 (2/2) 4-alpha-glucanotransferase
PF01120 (2/2) Alpha-L-fucosidase
PF00884 (2/2) Sulfatase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
precursor_groups_56273 531.52 +- 141.52 2 0 2 2 0.02 +- 0.02 2 8

PF13471 (2/2) Transglutaminase-like superfamily
PF13401 (2/2) AAA domain
PF08722 (2/2) TnsA endonuclease N terminal
PF06527 (2/2) TniQ
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (2/2) Peptidase family M20/M25/M40
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
precursor_groups_19484 194.60 +- 87.59 4 0 4 0 0.08 +- 0.20 4 14

TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01245 (4/4) anthranilate phosphoribosyltransferase
TIGR00566 (4/4) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF13432 (4/4) Tetratricopeptide repeat
PF13424 (4/4) Tetratricopeptide repeat
PF04715 (4/4) Anthranilate synthase component I, N terminal region
PF03704 (4/4) Bacterial transcriptional activator domain
PF02885 (4/4) Glycosyl transferase family, helical bundle domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF00931 (4/4) NB-ARC domain
PF00591 (4/4) Glycosyl transferase family, a/b domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00425 (4/4) chorismate binding enzyme
PF00117 (4/4) Glutamine amidotransferase class-I
precursor_groups_77609 265.88 +- 185.62 2 0 0 2 0.03 +- 0.05 2 4

PF13649 (2/2) Methyltransferase domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
precursor_groups_79448 1683.00 +- 123.00 2 0 0 0 0.01 +- 0.00 2 3

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
PF02515 (1/2) CoA-transferase family III
precursor_groups_77605 230.67 +- 116.00 2 0 0 0 0.02 +- 0.03 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_24702 58.19 +- 22.03 3 0 3 0 0.06 +- 0.10 3 6

TIGR02426 (3/3) 3-carboxy-cis,cis-muconate cycloisomerase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13454 (3/3) FAD-NAD(P)-binding
PF10397 (3/3) Adenylosuccinate lyase C-terminus
PF01474 (3/3) Class-II DAHP synthetase family
PF00206 (3/3) Lyase
precursor_groups_85980 228.36 +- 13.36 2 0 2 0 0.17 +- 0.30 2 24

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF18369 (1/2) Polyketide synthase dimerisation element domain
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13191 (1/2) AAA ATPase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_25386 123.98 +- 106.19 2 0 2 0 0.10 +- 0.21 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02195 (2/2) ParB-like nuclease domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08242 (1/2) Methyltransferase domain
PF04820 (1/2) Tryptophan halogenase
PF03621 (1/2) MbtH-like protein
PF00999 (1/2) Sodium/hydrogen exchanger family
PF00975 (1/2) Thioesterase domain
PF00067 (1/2) Cytochrome P450
precursor_groups_38593 158.26 +- 16.25 3 0 0 0 0.08 +- 0.07 3 19

PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF06831 (3/3) Formamidopyrimidine-DNA glycosylase H2TH domain
PF06827 (3/3) Zinc finger found in FPG and IleRS
PF05425 (3/3) Copper resistance protein D
PF04234 (3/3) CopC domain
PF02449 (3/3) Beta-galactosidase
PF02342 (3/3) TerD domain
PF02065 (3/3) Melibiase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01149 (3/3) Formamidopyrimidine-DNA glycosylase N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00440 (3/3) Bacterial regulatory proteins, tetR family
TIGR00229 (2/3) PAS domain S-box protein
PF13581 (2/3) Histidine kinase-like ATPase domain
PF08448 (2/3) PAS fold
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF01590 (2/3) GAF domain
PF00989 (2/3) PAS fold
precursor_groups_38590 903.00 +- 0.00 3 0 3 0 0.01 +- 0.00 3 9

PF12680 (3/3) SnoaL-like domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF07366 (3/3) SnoaL-like polyketide cyclase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00171 (3/3) Aldehyde dehydrogenase family
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_77552 31.52 +- 6.94 2 0 0 0 0.19 +- 0.22 2 10

TIGR00630 (2/2) excinuclease ABC subunit A
PF17755 (2/2) UvrA DNA-binding domain
PF14759 (2/2) Reductase C-terminal
PF13499 (2/2) EF-hand domain pair
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_2320 85.45 +- 86.32 7 0 0 0 0.11 +- 0.16 7 3

PF02515 (7/7) CoA-transferase family III
PF00082 (7/7) Subtilase family
PF05425 (6/7) Copper resistance protein D
precursor_groups_42645 4130.91 +- 755.96 3 0 0 0 0.01 +- 0.01 3 10

PF13814 (3/3) Replication-relaxation
PF13406 (3/3) Transglycosylase SLT domain
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF01476 (2/3) LysM domain
precursor_groups_5419 1038.26 +- 232.64 15 0 7 15 0.01 +- 0.01 15 6

TIGR04085 (15/15) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (15/15) Iron-sulfur cluster-binding domain
PF05402 (15/15) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (15/15) Radical SAM superfamily
PF01061 (15/15) ABC-2 type transporter
PF00005 (15/15) ABC transporter
precursor_groups_67644 55.71 +- 0.00 2 0 0 0 0.05 +- 0.06 2 4

TIGR01950 (2/2) redox-sensitive transcriptional activator SoxR
PF13411 (2/2) MerR HTH family regulatory protein
PF00877 (2/2) NlpC/P60 family
PF00069 (2/2) Protein kinase domain
precursor_groups_43192 1146.00 +- 338.46 3 0 0 0 0.01 +- 0.01 3 11

TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF14518 (3/3) Iron-containing redox enzyme
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00069 (3/3) Protein kinase domain
precursor_groups_52197 147.59 +- 112.41 2 0 0 0 0.03 +- 0.05 2 2

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
precursor_groups_39153 454.23 +- 0.00 2 0 2 0 0.11 +- 0.19 2 23

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01361 (2/2) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (2/2) DAHP synthase ferredoxin-like domain
PF13592 (2/2) Winged helix-turn helix
PF13551 (2/2) Winged helix-turn helix
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13191 (2/2) AAA ATPase domain
PF08242 (2/2) Methyltransferase domain
PF04820 (2/2) Tryptophan halogenase
PF03621 (2/2) MbtH-like protein
PF02195 (2/2) ParB-like nuclease domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00793 (2/2) DAHP synthetase I family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_24923 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_26658 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_74513 459.34 +- 58.01 2 0 1 1 0.06 +- 0.20 2 11

PF13649 (2/2) Methyltransferase domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13006 (2/2) Insertion element 4 transposase N-terminal
PF12730 (2/2) ABC-2 family transporter protein
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_78882 130.78 +- 92.08 2 0 0 0 0.05 +- 0.09 2 3

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01596 (2/2) O-methyltransferase
PF01474 (2/2) Class-II DAHP synthetase family
precursor_groups_78224 496.85 +- 117.44 2 0 2 2 0.02 +- 0.02 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13471 (2/2) Transglutaminase-like superfamily
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF00733 (2/2) Asparagine synthase
precursor_groups_31904 106.18 +- 2.15 2 0 2 0 0.05 +- 0.00 2 9

TIGR01060 (2/2) phosphopyruvate hydratase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF03952 (2/2) Enolase, N-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00113 (2/2) Enolase, C-terminal TIM barrel domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_19133 331.31 +- 98.19 4 0 4 0 0.01 +- 0.01 4 6

PF13459 (4/4) 4Fe-4S single cluster domain
PF10589 (4/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (4/4) TAP-like protein
PF03640 (4/4) Secreted repeat of unknown function
PF01512 (4/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (4/4) alpha/beta hydrolase fold
precursor_groups_52517 23.46 +- 3.14 2 0 0 2 0.17 +- 0.33 2 5

PF04972 (2/2) BON domain
PF00881 (2/2) Nitroreductase family
PF00571 (2/2) CBS domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_59943 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_19139 61.56 +- 8.87 3 0 0 0 0.20 +- 0.09 3 19

TIGR01810 (3/3) choline dehydrogenase
TIGR01374 (3/3) sarcosine oxidase, delta subunit family
TIGR01373 (3/3) sarcosine oxidase, beta subunit family
TIGR01186 (3/3) glycine betaine/L-proline transport ATP binding subunit
PF17806 (3/3) Sarcosine oxidase A3 domain
PF16350 (3/3) FAD dependent oxidoreductase central domain
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (3/3) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF05199 (3/3) GMC oxidoreductase
PF04268 (3/3) Sarcosine oxidase, gamma subunit family
PF04267 (3/3) Sarcosine oxidase, delta subunit family
PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (3/3) Aminomethyltransferase folate-binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00732 (3/3) GMC oxidoreductase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_groups_42734 20.73 +- 3.96 3 0 3 0 0.10 +- 0.10 3 4

PF13489 (3/3) Methyltransferase domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
precursor_groups_6261 118.60 +- 67.91 2 0 0 0 0.15 +- 0.19 2 10

PF13407 (2/2) Periplasmic binding protein domain
PF03060 (2/2) Nitronate monooxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_groups_12158 1912.00 +- 818.07 8 0 0 0 0.01 +- 0.01 8 12

PF17874 (8/8) MalT-like TPR region
PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00005 (8/8) ABC transporter
PF05193 (7/8) Peptidase M16 inactive domain
PF00675 (7/8) Insulinase (Peptidase family M16)
precursor_groups_43359 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_30613 10.38 +- 1.09 2 0 1 0 0.20 +- 0.02 2 12

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13478 (2/2) XdhC Rossmann domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
precursor_groups_9284 111.91 +- 99.69 2 0 0 0 0.11 +- 0.24 2 18

PF12728 (2/2) Helix-turn-helix domain
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF01580 (2/2) FtsK/SpoIIIE family
TIGR01764 (1/2) DNA binding domain, excisionase family
TIGR01613 (1/2) phage/plasmid primase, P4 family, C-terminal domain
PF17912 (1/2) MalK OB fold domain
PF12307 (1/2) Protein of unknown function (DUF3631)
PF11750 (1/2) Protein of unknown function (DUF3307)
PF10935 (1/2) Protein of unknown function (DUF2637)
PF08706 (1/2) D5 N terminal like
PF07702 (1/2) UTRA domain
PF03459 (1/2) TOBE domain
PF03288 (1/2) Poxvirus D5 protein-like
PF00589 (1/2) Phage integrase family
PF00483 (1/2) Nucleotidyl transferase
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00005 (1/2) ABC transporter
precursor_groups_17920 472.70 +- 171.61 5 0 3 0 0.02 +- 0.01 5 8

PF13416 (5/5) Bacterial extracellular solute-binding protein
PF09339 (5/5) IclR helix-turn-helix domain
PF05199 (5/5) GMC oxidoreductase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00732 (5/5) GMC oxidoreductase
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00480 (5/5) ROK family
PF00383 (5/5) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_42738 172.33 +- 60.58 3 0 1 0 0.02 +- 0.02 3 2

PF04299 (3/3) Putative FMN-binding domain
PF01494 (3/3) FAD binding domain
precursor_groups_82290 11.59 +- 1.76 2 0 0 0 0.18 +- 0.03 2 12

TIGR03424 (2/2) urea carboxylase-associated protein 1
TIGR02713 (2/2) allophanate hydrolase
TIGR02712 (2/2) urea carboxylase
PF09347 (2/2) Domain of unknown function (DUF1989)
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (2/2) Biotin carboxylase C-terminal domain
PF02682 (2/2) Carboxyltransferase domain, subdomain C and D
PF02626 (2/2) Carboxyltransferase domain, subdomain A and B
PF01425 (2/2) Amidase
PF00364 (2/2) Biotin-requiring enzyme
PF00289 (2/2) Biotin carboxylase, N-terminal domain
TIGR03425 (1/2) urea carboxylase-associated protein 2
precursor_groups_16250 12.53 +- 0.69 6 0 0 0 0.24 +- 0.03 6 5

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF04909 (6/6) Amidohydrolase
PF01575 (6/6) MaoC like domain
PF00501 (6/6) AMP-binding enzyme
precursor_groups_69364 2387.67 +- 710.67 2 0 0 0 0.01 +- 0.00 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00673 (2/2) cyanase
PF13379 (2/2) NMT1-like family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02566 (2/2) OsmC-like protein
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01613 (2/2) Flavin reductase like domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_63923 208.79 +- 51.21 2 0 2 0 0.05 +- 0.09 2 9

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07920 (2/2) Protein of unknown function (DUF1684)
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02655 (2/2) ATP-grasp domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (2/2) ABC transporter
precursor_groups_70236 146.83 +- 113.17 2 0 0 0 0.05 +- 0.08 2 7

PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00561 (2/2) alpha/beta hydrolase fold
PF08386 (1/2) TAP-like protein
precursor_groups_16256 94.48 +- 13.27 6 0 0 0 0.10 +- 0.05 6 8

PF16353 (6/6) Domain of unknown function(DUF4981)
PF13416 (6/6) Bacterial extracellular solute-binding protein
PF02929 (6/6) Beta galactosidase small chain
PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (6/6) Glycosyl hydrolases family 2
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_groups_74220 91.20 +- 16.95 2 0 0 0 0.12 +- 0.11 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01638 (2/2) HxlR-like helix-turn-helix
PF01613 (2/2) Flavin reductase like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_73502 188.42 +- 112.58 2 0 2 0 0.10 +- 0.25 2 13

TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF08241 (2/2) Methyltransferase domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_74223 272.52 +- 22.34 2 0 0 0 0.03 +- 0.04 2 7

TIGR01324 (2/2) cystathionine beta-lyase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00581 (2/2) Rhodanese-like domain
precursor_groups_73507 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_3038 245.85 +- 155.72 12 1 11 0 0.03 +- 0.06 11 8

PF13649 (12/12) Methyltransferase domain
PF00664 (12/12) ABC transporter transmembrane region
PF00005 (12/12) ABC transporter
PF12697 (11/12) Alpha/beta hydrolase family
PF13450 (10/12) NAD(P)-binding Rossmann-like domain
PF12821 (8/12) Threonine/Serine exporter, ThrE
PF06738 (8/12) Putative threonine/serine exporter
PF13518 (7/12) Helix-turn-helix domain
precursor_groups_22097 119.25 +- 51.04 5 0 1 0 0.09 +- 0.14 5 15

TIGR03026 (5/5) nucleotide sugar dehydrogenase
TIGR00696 (5/5) glycosyltransferase, WecB/TagA/CpsF family
PF14602 (5/5) Hexapeptide repeat of succinyl-transferase
PF13440 (5/5) Polysaccharide biosynthesis protein
PF03808 (5/5) Glycosyl transferase WecB/TagA/CpsF family
PF03721 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02350 (5/5) UDP-N-acetylglucosamine 2-epimerase
PF00984 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (5/5) Glycosyl transferase family 2
PF00132 (5/5) Bacterial transferase hexapeptide (six repeats)
TIGR00236 (4/5) UDP-N-acetylglucosamine 2-epimerase
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
PF01614 (3/5) Bacterial transcriptional regulator
PF00107 (3/5) Zinc-binding dehydrogenase
precursor_groups_6514 312.45 +- 238.56 5 0 1 1 0.06 +- 0.06 5 13

PF08352 (5/5) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00496 (5/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
TIGR03860 (4/5) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF02771 (4/5) Acyl-CoA dehydrogenase, N-terminal domain
TIGR03564 (3/5) F420-dependent oxidoreductase, MSMEG_4879 family
PF18029 (3/5) Glyoxalase-like domain
PF14226 (3/5) non-haem dioxygenase in morphine synthesis N-terminal
PF08028 (3/5) Acyl-CoA dehydrogenase, C-terminal domain
PF07920 (3/5) Protein of unknown function (DUF1684)
PF03171 (3/5) 2OG-Fe(II) oxygenase superfamily
precursor_groups_58006 406.57 +- 109.43 2 0 2 0 0.01 +- 0.00 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_3745 92.55 +- 24.72 2 0 2 0 0.05 +- 0.03 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08241 (2/2) Methyltransferase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
precursor_groups_6043 114.33 +- 17.12 5 0 0 0 0.11 +- 0.06 5 10

TIGR01382 (5/5) intracellular protease, PfpI family
PF13823 (5/5) Alcohol dehydrogenase GroES-associated
PF09123 (5/5) Domain of unknown function (DUF1931)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF01965 (5/5) DJ-1/PfpI family
PF00248 (5/5) Aldo/keto reductase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF13515 (4/5) Fusaric acid resistance protein-like
PF12805 (4/5) FUSC-like inner membrane protein yccS
precursor_groups_42821 125.90 +- 35.46 2 0 2 0 0.18 +- 0.28 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01123 (2/2) branched-chain amino acid aminotransferase
PF13560 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF08242 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03621 (2/2) MbtH-like protein
PF02310 (2/2) B12 binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01129 (2/2) NAD:arginine ADP-ribosyltransferase
PF01063 (2/2) Amino-transferase class IV
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
precursor_groups_71286 680.00 +- 35.00 2 0 1 0 0.01 +- 0.02 2 9

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF01636 (2/2) Phosphotransferase enzyme family
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_groups_71289 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
precursor_groups_25722 129.98 +- 56.91 4 0 0 0 0.06 +- 0.18 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13535 (4/4) ATP-grasp domain
PF13434 (4/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (4/4) tRNA synthetases class I (M)
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02274 (4/4) Amidinotransferase
PF01266 (4/4) FAD dependent oxidoreductase
PF00999 (4/4) Sodium/hydrogen exchanger family
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF04073 (3/4) Aminoacyl-tRNA editing domain
PF03738 (2/4) Glutathionylspermidine synthase preATP-grasp
precursor_groups_12716 559.21 +- 113.53 5 0 0 0 0.03 +- 0.02 5 5

PF13407 (5/5) Periplasmic binding protein domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00652 (5/5) Ricin-type beta-trefoil lectin domain
PF00005 (5/5) ABC transporter
precursor_groups_26139 154.04 +- 26.04 3 0 0 0 0.22 +- 0.32 3 11

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_28845 28.15 +- 5.04 2 0 0 0 0.11 +- 0.07 2 3

PF13489 (2/2) Methyltransferase domain
PF05685 (2/2) Putative restriction endonuclease
PF02082 (2/2) Transcriptional regulator
precursor_groups_1892 56.36 +- 0.21 3 0 0 0 0.25 +- 0.34 3 9

TIGR00879 (3/3) MFS transporter, sugar porter (SP) family
TIGR00745 (3/3) 2-dehydropantoate 2-reductase
PF08546 (3/3) Ketopantoate reductase PanE/ApbA C terminal
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF02558 (3/3) Ketopantoate reductase PanE/ApbA
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00083 (3/3) Sugar (and other) transporter
precursor_groups_18064 757.69 +- 655.20 5 0 5 0 0.04 +- 0.14 5 13

TIGR01733 (5/5) amino acid adenylation domain
TIGR00652 (5/5) diaminopimelate epimerase
PF14518 (5/5) Iron-containing redox enzyme
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10014 (5/5) 2OG-Fe dioxygenase
PF05977 (5/5) Transmembrane secretion effector
PF01678 (5/5) Diaminopimelate epimerase
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF03621 (4/5) MbtH-like protein
precursor_groups_14279 333.45 +- 164.95 6 0 1 0 0.02 +- 0.03 6 5

PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF16859 (5/6) Tetracyclin repressor-like, C-terminal domain
PF03992 (5/6) Antibiotic biosynthesis monooxygenase
PF01243 (5/6) Pyridoxamine 5'-phosphate oxidase
PF00111 (5/6) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_3326 233.04 +- 195.01 7 0 6 0 0.05 +- 0.06 7 7

PF12728 (7/7) Helix-turn-helix domain
PF08402 (7/7) TOBE domain
PF03459 (7/7) TOBE domain
PF00005 (7/7) ABC transporter
PF13343 (6/7) Bacterial extracellular solute-binding protein
PF00528 (6/7) Binding-protein-dependent transport system inner membrane component
PF06236 (5/7) Tyrosinase co-factor MelC1
precursor_groups_3635 29.57 +- 2.68 2 0 2 0 0.10 +- 0.21 2 6

TIGR00040 (2/2) phosphodiesterase, MJ0936 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12850 (2/2) Calcineurin-like phosphoesterase superfamily domain
PF12802 (2/2) MarR family
PF05257 (2/2) CHAP domain
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_12974 482.02 +- 29.43 3 0 0 0 0.02 +- 0.03 3 10

PF12833 (3/3) Helix-turn-helix domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02311 (3/3) AraC-like ligand binding domain
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00664 (3/3) ABC transporter transmembrane region
PF00561 (3/3) alpha/beta hydrolase fold
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_groups_7338 71.91 +- 29.46 9 0 9 0 0.03 +- 0.03 9 3

TIGR03083 (9/9) uncharacterized Actinobacterial protein TIGR03083
PF11716 (9/9) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02627 (9/9) Carboxymuconolactone decarboxylase family
precursor_groups_12978 17.86 +- 6.20 4 0 0 0 0.19 +- 0.20 4 4

PF01757 (4/4) Acyltransferase family
PF00571 (4/4) CBS domain
PF03471 (3/4) Transporter associated domain
PF01595 (3/4) Cyclin M transmembrane N-terminal domain
precursor_groups_54749 24.36 +- 1.42 2 0 2 0 0.12 +- 0.27 2 4

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF00501 (2/2) AMP-binding enzyme
PF00067 (2/2) Cytochrome P450
precursor_groups_72586 1036.00 +- 4.00 2 0 0 0 0.01 +- 0.00 2 6

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_48714 117.68 +- 11.32 2 0 0 0 0.03 +- 0.00 2 7

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF14310 (2/2) Fibronectin type III-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_68926 101.11 +- 6.89 2 0 0 0 0.12 +- 0.22 2 7

PF12679 (2/2) ABC-2 family transporter protein
PF07883 (2/2) Cupin domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
precursor_groups_31885 40.07 +- 16.21 3 0 0 0 0.09 +- 0.07 3 6

PF09206 (3/3) Alpha-L-arabinofuranosidase B, catalytic
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF06283 (3/3) Trehalose utilisation
PF03422 (3/3) Carbohydrate binding module (family 6)
PF00801 (3/3) PKD domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_groups_71138 334.62 +- 22.62 2 0 2 0 0.03 +- 0.01 2 6

PF13560 (2/2) Helix-turn-helix domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_43774 691.01 +- 84.49 3 0 3 0 0.07 +- 0.18 3 17

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/3) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/3) Beta-lactamase superfamily domain
PF12697 (3/3) Alpha/beta hydrolase family
PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/3) ParB-like nuclease domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
precursor_groups_83774 32.50 +- 0.00 2 0 0 0 0.12 +- 0.10 2 8

TIGR01695 (2/2) murein biosynthesis integral membrane protein MurJ
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03023 (2/2) Lipid II flippase MurJ
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_groups_41937 915.56 +- 502.62 2 0 0 0 0.01 +- 0.01 2 8

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_11372 68.67 +- 12.26 3 0 0 0 0.04 +- 0.05 3 7

PF14435 (3/3) SUKH-4 immunity protein
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_9191 53.26 +- 10.52 4 0 0 0 0.18 +- 0.12 4 7

PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF08533 (3/4) Beta-galactosidase C-terminal domain
precursor_groups_11374 198.26 +- 30.71 4 0 0 0 0.02 +- 0.01 4 6

PF12740 (4/4) Chlorophyllase enzyme
PF08223 (4/4) PaaX-like protein C-terminal domain
PF07848 (4/4) PaaX-like protein
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF00069 (4/4) Protein kinase domain
PF17765 (2/4) MmyB-like transcription regulator ligand binding domain
precursor_groups_3924 61.57 +- 45.93 2 0 1 0 0.06 +- 0.06 2 9

TIGR00157 (1/2) ribosome small subunit-dependent GTPase A
PF13649 (1/2) Methyltransferase domain
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF08241 (1/2) Methyltransferase domain
PF03193 (1/2) RsgA GTPase
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00005 (1/2) ABC transporter
precursor_groups_70424 285.15 +- 1.52 2 0 2 2 0.03 +- 0.03 2 4

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
PF03771 (1/2) Domain of unknown function (DUF317)
precursor_groups_61964 561.39 +- 83.61 2 0 0 0 0.02 +- 0.03 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_82185 1309.55 +- 19.55 2 0 0 0 0.01 +- 0.00 2 10

PF13560 (2/2) Helix-turn-helix domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13144 (1/2) Chaperone for flagella basal body P-ring formation
PF08666 (1/2) SAF domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
precursor_groups_36721 86.41 +- 4.85 2 0 0 0 0.19 +- 0.33 2 8

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF10609 (2/2) NUBPL iron-transfer P-loop NTPase
PF07811 (2/2) TadE-like protein
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_9986 501.04 +- 237.72 9 0 9 9 0.03 +- 0.02 9 8

TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF05147 (9/9) Lanthionine synthetase C-like protein
PF05139 (9/9) Erythromycin esterase
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF00296 (9/9) Luciferase-like monooxygenase
PF00196 (9/9) Bacterial regulatory proteins, luxR family
PF00005 (9/9) ABC transporter
precursor_groups_16875 51.61 +- 16.49 6 0 0 0 0.10 +- 0.09 6 5

TIGR00456 (6/6) arginine--tRNA ligase
PF05746 (6/6) DALR anticodon binding domain
PF03485 (6/6) Arginyl tRNA synthetase N terminal domain
PF00750 (6/6) tRNA synthetases class I (R)
PF00561 (6/6) alpha/beta hydrolase fold
precursor_groups_4223 323.50 +- 63.50 2 0 0 0 0.01 +- 0.00 2 2

PF02515 (2/2) CoA-transferase family III
PF00082 (2/2) Subtilase family
precursor_groups_28574 274.58 +- 189.71 2 0 2 0 0.03 +- 0.05 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_43103 21.96 +- 12.28 3 0 0 0 0.18 +- 0.18 3 4

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00501 (3/3) AMP-binding enzyme
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF01145 (2/3) SPFH domain / Band 7 family
precursor_groups_32562 31.52 +- 8.48 2 0 0 0 0.11 +- 0.10 2 5

PF13377 (2/2) Periplasmic binding protein-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF02515 (1/2) CoA-transferase family III
precursor_groups_16878 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF06912 (2/2) Protein of unknown function (DUF1275)
PF00293 (2/2) NUDIX domain
precursor_groups_55831 57.11 +- 1.39 2 0 2 0 0.05 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05675 (2/2) Protein of unknown function (DUF817)
PF01810 (2/2) LysE type translocator
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_8685 11.03 +- 3.58 3 0 0 0 0.22 +- 0.18 3 5

PF02803 (3/3) Thiolase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_groups_23546 339.67 +- 75.22 2 0 0 0 0.07 +- 0.06 2 18

PF13672 (2/2) Protein phosphatase 2C
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01047 (2/2) MarR family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
TIGR03211 (1/2) catechol 2,3 dioxygenase
PF13796 (1/2) Putative sensor
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF00400 (1/2) WD domain, G-beta repeat
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
precursor_groups_80928 121.33 +- 34.67 2 0 2 2 0.02 +- 0.01 2 2

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
precursor_groups_51085 35.34 +- 0.78 2 0 2 0 0.08 +- 0.10 2 4

PF13712 (2/2) Glycosyltransferase like family
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00483 (2/2) Nucleotidyl transferase
precursor_groups_4914 155.37 +- 59.58 4 0 0 0 0.03 +- 0.05 4 8

PF07728 (4/4) AAA domain (dynein-related subfamily)
PF07690 (4/4) Major Facilitator Superfamily
PF00535 (4/4) Glycosyl transferase family 2
PF12696 (3/4) TraM recognition site of TraD and TraG
PF03771 (3/4) Domain of unknown function (DUF317)
PF02899 (3/4) Phage integrase, N-terminal SAM-like domain
PF00772 (3/4) DnaB-like helicase N terminal domain
PF00145 (3/4) C-5 cytosine-specific DNA methylase
precursor_groups_8043 114.25 +- 80.75 2 0 0 0 0.07 +- 0.11 2 10

PF13649 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03601 (1/2) Conserved hypothetical protein 698
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01527 (1/2) Transposase
PF01494 (1/2) FAD binding domain
PF00665 (1/2) Integrase core domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_69784 333.38 +- 53.62 2 0 0 0 0.09 +- 0.04 2 9

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
precursor_groups_26270 387.13 +- 245.71 4 0 0 0 0.05 +- 0.05 4 8

TIGR01821 (4/4) 5-aminolevulinic acid synthase
PF07690 (4/4) Major Facilitator Superfamily
PF06224 (4/4) Winged helix DNA-binding domain
PF03466 (4/4) LysR substrate binding domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00155 (4/4) Aminotransferase class I and II
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_1278 192.82 +- 232.12 3 0 1 0 0.11 +- 0.22 3

No common domains found
precursor_groups_41586 130.81 +- 22.43 3 0 0 0 0.07 +- 0.04 3 5

PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_4357 37.32 +- 36.01 10 0 0 0 0.10 +- 0.06 10 3

PF13480 (10/10) Acetyltransferase (GNAT) domain
PF01522 (10/10) Polysaccharide deacetylase
PF00535 (10/10) Glycosyl transferase family 2
precursor_groups_23762 64.68 +- 17.93 3 0 0 0 0.05 +- 0.03 3 5

TIGR00842 (3/3) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02386 (3/3) Cation transport protein
PF02254 (3/3) TrkA-N domain
PF02080 (3/3) TrkA-C domain
PF02028 (3/3) BCCT, betaine/carnitine/choline family transporter
precursor_groups_1270 186.57 +- 110.92 37 0 37 0 0.04 +- 0.02 37 3

PF11991 (37/37) Tryptophan dimethylallyltransferase
PF07690 (37/37) Major Facilitator Superfamily
PF00155 (37/37) Aminotransferase class I and II
precursor_groups_15497 1363.59 +- 571.41 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_62458 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_80671 1749.12 +- 1506.53 2 0 2 0 0.08 +- 0.25 2 37

PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00999 (2/2) Sodium/hydrogen exchanger family
TIGR02039 (1/2) sulfate adenylyltransferase, small subunit
TIGR02034 (1/2) sulfate adenylyltransferase, large subunit
TIGR01762 (1/2) chlorinating enzyme
TIGR01733 (1/2) amino acid adenylation domain
TIGR00670 (1/2) aspartate carbamoyltransferase
TIGR00455 (1/2) adenylyl-sulfate kinase
TIGR00157 (1/2) ribosome small subunit-dependent GTPase A
PF17837 (1/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13714 (1/2) Phosphoenolpyruvate phosphomutase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12900 (1/2) Pyridoxamine 5'-phosphate oxidase
PF08242 (1/2) Methyltransferase domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03621 (1/2) MbtH-like protein
PF03193 (1/2) RsgA GTPase
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02729 (1/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01583 (1/2) Adenylylsulphate kinase
PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00459 (1/2) Inositol monophosphatase family
PF00326 (1/2) Prolyl oligopeptidase family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00185 (1/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II
PF00009 (1/2) Elongation factor Tu GTP binding domain
precursor_groups_4592 36.98 +- 6.02 2 0 0 0 0.07 +- 0.04 2 6

PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07730 (2/2) Histidine kinase
PF00890 (2/2) FAD binding domain
PF00083 (2/2) Sugar (and other) transporter
PF00106 (1/2) short chain dehydrogenase
precursor_groups_1073 1282.73 +- 753.60 4 0 0 0 0.02 +- 0.08 4 9

TIGR03930 (4/4) WXG100 family type VII secretion target
PF06259 (4/4) Alpha/beta hydrolase
PF06013 (4/4) Proteins of 100 residues with WXG
TIGR03921 (3/4) type VII secretion-associated serine protease mycosin
TIGR03920 (3/4) type VII secretion integral membrane protein EccD
TIGR03919 (3/4) type VII secretion protein EccB
PF08817 (3/4) WXG100 protein secretion system (Wss), protein YukD
PF05108 (3/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/4) Subtilase family
precursor_groups_4594 14.22 +- 0.78 2 0 0 0 0.21 +- 0.20 2 3

PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF01554 (1/2) MatE
precursor_groups_30827 232.92 +- 168.42 2 0 2 0 0.04 +- 0.05 2 7

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (2/2) CoA-transferase family III
PF01494 (2/2) FAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_15499 18.05 +- 3.85 2 0 1 0 0.14 +- 0.11 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF11991 (1/2) Tryptophan dimethylallyltransferase
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_37580 10.28 +- 0.64 3 0 3 0 0.20 +- 0.34 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03621 (3/3) MbtH-like protein
PF00501 (3/3) AMP-binding enzyme
precursor_groups_1673 541.74 +- 490.47 30 0 29 29 0.05 +- 0.12 30 6

PF00664 (30/30) ABC transporter transmembrane region
PF00326 (30/30) Prolyl oligopeptidase family
PF00005 (30/30) ABC transporter
PF05147 (29/30) Lanthionine synthetase C-like protein
PF00069 (29/30) Protein kinase domain
PF04672 (28/30) S-adenosyl methyltransferase
precursor_groups_73316 369.47 +- 215.53 2 0 0 0 0.05 +- 0.09 2 8

PF14592 (2/2) Chondroitinase B
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01120 (2/2) Alpha-L-fucosidase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR03804 (1/2) parallel beta-helix repeat
PF05899 (1/2) Protein of unknown function (DUF861)
precursor_groups_30919 256.07 +- 76.34 4 0 0 0 0.02 +- 0.01 4 2

PF01757 (4/4) Acyltransferase family
PF01522 (4/4) Polysaccharide deacetylase
precursor_groups_73867 135.29 +- 122.71 2 0 0 0 0.08 +- 0.11 2 2

PF13458 (2/2) Periplasmic binding protein
PF00069 (2/2) Protein kinase domain
precursor_groups_1678 208.56 +- 192.77 2 0 1 0 0.07 +- 0.10 2 20

PF08022 (2/2) FAD-binding domain
PF04205 (2/2) FMN-binding domain
PF02424 (2/2) ApbE family
PF01794 (2/2) Ferric reductase like transmembrane component
PF00175 (2/2) Oxidoreductase NAD-binding domain
TIGR01426 (1/2) glycosyltransferase, MGT family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF03060 (1/2) Nitronate monooxygenase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (1/2) Acyl transferase domain
PF00664 (1/2) ABC transporter transmembrane region
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter
precursor_groups_8460 21.38 +- 15.59 4 0 0 0 0.17 +- 0.11 4 6

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF04909 (4/4) Amidohydrolase
PF01575 (4/4) MaoC like domain
PF00501 (4/4) AMP-binding enzyme
TIGR01923 (3/4) O-succinylbenzoate-CoA ligase
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
precursor_groups_44208 26.35 +- 4.85 2 0 0 0 0.15 +- 0.26 2 8

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF07690 (2/2) Major Facilitator Superfamily
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF05437 (1/2) Branched-chain amino acid transport protein (AzlD)
PF03591 (1/2) AzlC protein
precursor_groups_61097 16.82 +- 0.21 2 0 0 0 0.24 +- 0.33 2 9

PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00741 (2/2) Gas vesicle protein
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_9401 220.64 +- 131.76 10 0 0 0 0.02 +- 0.03 10 3

PF01145 (10/10) SPFH domain / Band 7 family
PF00877 (10/10) NlpC/P60 family
PF00196 (10/10) Bacterial regulatory proteins, luxR family
precursor_groups_20494 73.71 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR01472 (2/2) GDP-mannose 4,6-dehydratase
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13641 (2/2) Glycosyltransferase like family 2
PF05050 (2/2) Methyltransferase FkbM domain
PF04932 (2/2) O-Antigen ligase
precursor_groups_69133 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
precursor_groups_53977 579.66 +- 12.06 2 0 0 0 0.02 +- 0.03 2 8

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF08007 (2/2) Cupin superfamily protein
PF07371 (2/2) Protein of unknown function (DUF1490)
PF01297 (2/2) Zinc-uptake complex component A periplasmic
PF00950 (2/2) ABC 3 transport family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_groups_70734 174.69 +- 44.69 2 0 0 0 0.06 +- 0.02 2 4

PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_82293 171.87 +- 30.05 2 0 0 0 0.04 +- 0.03 2 8

TIGR00842 (2/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF16951 (2/2) Putative methionine and alanine importer, small subunit
PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF02028 (2/2) BCCT, betaine/carnitine/choline family transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF00209 (2/2) Sodium:neurotransmitter symporter family
PF00085 (2/2) Thioredoxin
precursor_groups_21947 466.20 +- 126.85 5 0 5 0 0.01 +- 0.00 5 6

PF03412 (5/5) Peptidase C39 family
PF00668 (5/5) Condensation domain
PF00664 (5/5) ABC transporter transmembrane region
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00005 (5/5) ABC transporter
precursor_groups_38423 136.50 +- 19.50 2 0 0 0 0.03 +- 0.01 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF09339 (2/2) IclR helix-turn-helix domain
PF02525 (2/2) Flavodoxin-like fold
PF01614 (2/2) Bacterial transcriptional regulator
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF01494 (1/2) FAD binding domain
precursor_groups_3742 58.80 +- 18.26 7 0 0 0 0.21 +- 0.17 7 7

TIGR03860 (7/7) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (7/7) NMT1/THI5 like
PF02668 (7/7) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00480 (7/7) ROK family
PF00296 (7/7) Luciferase-like monooxygenase
PF00005 (7/7) ABC transporter
precursor_groups_62523 601.71 +- 122.57 2 0 0 2 0.01 +- 0.00 2 11

PF16864 (2/2) Dimerisation domain
PF13649 (2/2) Methyltransferase domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00891 (2/2) O-methyltransferase domain
PF00670 (2/2) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
precursor_groups_1416 234.79 +- 200.58 2 0 0 2 0.05 +- 0.14 2 6

PF13599 (2/2) Pentapeptide repeats (9 copies)
PF04055 (2/2) Radical SAM superfamily
PF13560 (1/2) Helix-turn-helix domain
PF08241 (1/2) Methyltransferase domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_20127 320.43 +- 63.17 3 0 3 0 0.03 +- 0.06 3 14

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13183 (3/3) 4Fe-4S dicluster domain
PF10370 (3/3) Domain of unknown function (DUF2437)
PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01565 (3/3) FAD binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_62034 25.03 +- 0.62 2 0 0 0 0.20 +- 0.24 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04909 (2/2) Amidohydrolase
PF01575 (2/2) MaoC like domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_67007 518.00 +- 2.00 2 0 0 0 0.01 +- 0.00 2 6

PF13469 (2/2) Sulfotransferase family
PF05977 (2/2) Transmembrane secretion effector
PF02274 (2/2) Amidinotransferase
PF02065 (2/2) Melibiase
PF01583 (2/2) Adenylylsulphate kinase
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_73409 130.62 +- 30.62 2 0 0 2 0.04 +- 0.07 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF12840 (1/2) Helix-turn-helix domain
precursor_groups_80071 269.33 +- 73.11 2 0 0 0 0.07 +- 0.05 2 7

PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (2/2) Alpha mannosidase middle domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_15727 297.39 +- 131.92 6 0 1 0 0.02 +- 0.02 6 5

PF13404 (6/6) AsnC-type helix-turn-helix domain
PF07969 (6/6) Amidohydrolase family
PF02133 (6/6) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01037 (6/6) Lrp/AsnC ligand binding domain
PF00583 (6/6) Acetyltransferase (GNAT) family
precursor_groups_36186 36.46 +- 1.28 2 0 0 0 0.08 +- 0.06 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01569 (2/2) PAP2 superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_14634 62.70 +- 28.47 4 0 3 0 0.15 +- 0.20 4 6

PF05331 (4/4) Protein of unknown function (DUF742)
PF03259 (4/4) Roadblock/LC7 domain
PF03029 (4/4) Conserved hypothetical ATP binding protein
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF11991 (3/4) Tryptophan dimethylallyltransferase
PF01212 (3/4) Beta-eliminating lyase
precursor_groups_65938 49.12 +- 1.36 2 0 0 0 0.12 +- 0.12 2 5

TIGR00456 (2/2) arginine--tRNA ligase
PF05746 (2/2) DALR anticodon binding domain
PF03485 (2/2) Arginyl tRNA synthetase N terminal domain
PF00750 (2/2) tRNA synthetases class I (R)
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_84004 52.52 +- 39.62 2 0 0 0 0.13 +- 0.27 2 10

TIGR01167 (2/2) LPXTG cell wall anchor domain
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01872 (2/2) RibD C-terminal domain
PF01590 (2/2) GAF domain
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00989 (2/2) PAS fold
PF00465 (2/2) Iron-containing alcohol dehydrogenase
precursor_groups_21544 75.17 +- 52.09 3 0 1 2 0.07 +- 0.07 3 5

TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/3) Glutamine amidotransferase domain
PF05141 (2/3) Pyoverdine/dityrosine biosynthesis protein
PF00733 (2/3) Asparagine synthase
PF00067 (2/3) Cytochrome P450
precursor_groups_20834 20.35 +- 6.27 5 0 0 0 0.13 +- 0.09 5 4

PF17801 (5/5) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (5/5) Alpha galactosidase A
PF09206 (5/5) Alpha-L-arabinofuranosidase B, catalytic
PF00652 (5/5) Ricin-type beta-trefoil lectin domain
precursor_groups_15121 709.66 +- 544.71 6 0 6 0 0.03 +- 0.12 6 25

TIGR01821 (6/6) 5-aminolevulinic acid synthase
PF08545 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05977 (6/6) Transmembrane secretion effector
PF03704 (6/6) Bacterial transcriptional activator domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF02655 (6/6) ATP-grasp domain
PF00931 (6/6) NB-ARC domain
PF00155 (6/6) Aminotransferase class I and II
TIGR01733 (5/6) amino acid adenylation domain
PF18603 (5/6) L-amino acid ligase C-terminal domain 2
PF18130 (5/6) ATP-grasp N-terminal domain
PF13535 (5/6) ATP-grasp domain
PF13424 (5/6) Tetratricopeptide repeat
PF13193 (5/6) AMP-binding enzyme C-terminal domain
PF07690 (5/6) Major Facilitator Superfamily
PF01212 (5/6) Beta-eliminating lyase
PF00975 (5/6) Thioesterase domain
PF00668 (5/6) Condensation domain
PF00550 (5/6) Phosphopantetheine attachment site
PF00501 (5/6) AMP-binding enzyme
PF00487 (5/6) Fatty acid desaturase
PF00291 (5/6) Pyridoxal-phosphate dependent enzyme
PF00288 (5/6) GHMP kinases N terminal domain
PF00206 (5/6) Lyase
precursor_groups_46733 246.26 +- 120.66 3 0 0 0 0.14 +- 0.13 3 21

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF04909 (3/3) Amidohydrolase
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00248 (3/3) Aldo/keto reductase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
PF09084 (2/3) NMT1/THI5 like
PF05025 (2/3) RbsD / FucU transport protein family
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00175 (2/3) Oxidoreductase NAD-binding domain
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_199 16.97 +- 4.28 4 0 1 0 0.13 +- 0.05 4 4

TIGR01810 (3/4) choline dehydrogenase
PF05199 (3/4) GMC oxidoreductase
PF02219 (3/4) Methylenetetrahydrofolate reductase
PF00732 (3/4) GMC oxidoreductase
precursor_groups_15659 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
precursor_groups_9313 709.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 8

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF17132 (2/2) alpha-L-rhamnosidase
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02057 (2/2) Glycosyl hydrolase family 59
precursor_groups_321 125.84 +- 131.68 3 0 0 0 0.04 +- 0.03 3 2

PF08007 (3/3) Cupin superfamily protein
PF00248 (2/3) Aldo/keto reductase family
precursor_groups_33021 78.36 +- 10.26 2 0 0 0 0.15 +- 0.11 2 20

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01186 (2/2) glycine betaine/L-proline transport ATP binding subunit
PF16350 (2/2) FAD dependent oxidoreductase central domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF17829 (1/2) Gylcosyl hydrolase family 115 C-terminal domain
PF17806 (1/2) Sarcosine oxidase A3 domain
PF15979 (1/2) Glycosyl hydrolase family 115
PF14099 (1/2) Polysaccharide lyase
PF13460 (1/2) NAD(P)H-binding
PF04268 (1/2) Sarcosine oxidase, gamma subunit family
precursor_groups_323 71.11 +- 60.56 5 0 0 0 0.07 +- 0.08 5 4

TIGR00008 (3/5) translation initiation factor IF-1
PF13673 (3/5) Acetyltransferase (GNAT) domain
PF03992 (3/5) Antibiotic biosynthesis monooxygenase
PF01176 (3/5) Translation initiation factor 1A / IF-1
precursor_groups_21833 269.86 +- 86.45 5 0 5 0 0.02 +- 0.01 5 8

TIGR00517 (5/5) acyl carrier protein
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_73195 390.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03589 (2/2) UDP-N-acetylglucosamine 4,6-dehydratase (inverting)
TIGR02246 (2/2) conserved hypothetical protein
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF02719 (2/2) Polysaccharide biosynthesis protein
PF01425 (2/2) Amidase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_5886 274.31 +- 221.84 2 0 1 1 0.03 +- 0.05 2 12

PF18143 (1/2) HAD domain in Swiss Army Knife RNA repair proteins
PF13649 (1/2) Methyltransferase domain
PF13333 (1/2) Integrase core domain
PF13276 (1/2) HTH-like domain
PF04055 (1/2) Radical SAM superfamily
PF02223 (1/2) Thymidylate kinase
PF01636 (1/2) Phosphotransferase enzyme family
PF01527 (1/2) Transposase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00884 (1/2) Sulfatase
PF00665 (1/2) Integrase core domain
PF00293 (1/2) NUDIX domain
precursor_groups_328 36.03 +- 8.66 4 0 2 0 0.08 +- 0.09 4

No common domains found
precursor_groups_5888 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_groups_61549 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_59406 242.62 +- 47.62 2 0 0 0 0.01 +- 0.01 2 3

PF01738 (2/2) Dienelactone hydrolase family
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_groups_59402 101.74 +- 2.23 2 0 0 0 0.09 +- 0.15 2 10

PF12840 (2/2) Helix-turn-helix domain
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00582 (2/2) Universal stress protein family
PF00571 (2/2) CBS domain
PF00374 (2/2) Nickel-dependent hydrogenase
PF00361 (2/2) Proton-conducting membrane transporter
PF00346 (2/2) Respiratory-chain NADH dehydrogenase, 49 Kd subunit
PF00329 (2/2) Respiratory-chain NADH dehydrogenase, 30 Kd subunit
PF00146 (2/2) NADH dehydrogenase
precursor_groups_79616 412.94 +- 0.00 2 0 0 0 0.03 +- 0.02 2 11

PF13407 (2/2) Periplasmic binding protein domain
PF07729 (2/2) FCD domain
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01979 (2/2) Amidohydrolase family
PF01968 (2/2) Hydantoinase/oxoprolinase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
precursor_groups_1303 182.76 +- 33.91 2 0 0 0 0.02 +- 0.01 2 7

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
TIGR01451 (2/2) conserved repeat domain
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13489 (2/2) Methyltransferase domain
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF01345 (2/2) Domain of unknown function DUF11
precursor_groups_24061 88.83 +- 6.73 2 0 0 0 0.04 +- 0.05 2 2

PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_54348 40.78 +- 2.56 2 0 0 0 0.10 +- 0.15 2 4

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_groups_56845 502.18 +- 50.68 2 0 0 0 0.01 +- 0.00 2 4

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
precursor_groups_10840 246.68 +- 140.32 2 0 2 0 0.02 +- 0.02 2 4

PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_67318 140.32 +- 82.54 2 0 0 0 0.07 +- 0.19 2 12

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06684 (2/2) Amino acid synthesis
PF01361 (2/2) Tautomerase enzyme
PF00668 (2/2) Condensation domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_58681 53.08 +- 4.70 2 0 0 0 0.08 +- 0.08 2 4

TIGR02547 (2/2) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
PF13649 (2/2) Methyltransferase domain
PF09481 (2/2) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_groups_24069 328.45 +- 257.44 4 0 0 0 0.03 +- 0.02 4 16

TIGR03804 (4/4) parallel beta-helix repeat
TIGR03641 (4/4) CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP
TIGR02593 (4/4) CRISPR-associated protein Cas5
TIGR02585 (4/4) CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP
TIGR01877 (4/4) CRISPR-associated endoribonuclease Cas6
TIGR01596 (4/4) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (4/4) CRISPR-associated helicase Cas3
TIGR01573 (4/4) CRISPR-associated endonuclease Cas2
PF18019 (4/4) HD domain
PF13229 (4/4) Right handed beta helix region
PF09827 (4/4) CRISPR associated protein Cas2
PF09704 (4/4) CRISPR-associated protein (Cas_Cas5)
PF01930 (4/4) Domain of unknown function DUF83
PF01881 (4/4) CRISPR associated protein Cas6
PF01867 (4/4) CRISPR associated protein Cas1
PF00270 (4/4) DEAD/DEAH box helicase
precursor_groups_37223 344.00 +- 121.62 3 0 0 0 0.01 +- 0.00 3 5

PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF03551 (3/3) Transcriptional regulator PadR-like family
PF00884 (3/3) Sulfatase
precursor_groups_14525 813.33 +- 308.97 6 0 6 0 0.01 +- 0.00 6 16

PF03621 (6/6) MbtH-like protein
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
TIGR04020 (5/6) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (5/6) amino acid adenylation domain
TIGR01720 (5/6) non-ribosomal peptide synthase domain TIGR01720
PF18563 (5/6) TubC N-terminal docking domain
PF16197 (5/6) Ketoacyl-synthetase C-terminal extension
PF13193 (5/6) AMP-binding enzyme C-terminal domain
PF08242 (5/6) Methyltransferase domain
PF02801 (5/6) Beta-ketoacyl synthase, C-terminal domain
PF02668 (5/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (5/6) Acyl transferase domain
PF00668 (5/6) Condensation domain
PF00296 (5/6) Luciferase-like monooxygenase
PF00109 (5/6) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_14524 92.15 +- 47.08 3 0 2 0 0.04 +- 0.06 3 4

PF13191 (3/3) AAA ATPase domain
PF00067 (3/3) Cytochrome P450
PF17829 (2/3) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (2/3) Glycosyl hydrolase family 115
precursor_groups_41327 518.00 +- 2.00 2 0 0 2 0.01 +- 0.00 2 9

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF05977 (2/2) Transmembrane secretion effector
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_groups_46115 140.60 +- 64.81 3 0 0 0 0.03 +- 0.04 3 5

PF13564 (3/3) DoxX-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (3/3) NADPH-dependent FMN reductase
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_40662 119.28 +- 22.53 2 0 0 0 0.02 +- 0.02 2 3

PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
PF08877 (1/2) MepB protein
precursor_groups_33752 211.48 +- 69.43 3 0 1 0 0.03 +- 0.04 3 6

PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
TIGR00212 (2/3) hydroxymethylbilane synthase
PF03900 (2/3) Porphobilinogen deaminase, C-terminal domain
PF01636 (2/3) Phosphotransferase enzyme family
PF01379 (2/3) Porphobilinogen deaminase, dipyromethane cofactor binding domain
precursor_groups_9139 7843.20 +- 6508.80 2 0 2 2 0.05 +- 0.15 2 21

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_groups_10141 21.71 +- 2.22 3 0 0 0 0.19 +- 0.13 3 10

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13247 (3/3) 4Fe-4S dicluster domain
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_groups_21723 136.40 +- 32.63 3 0 3 0 0.10 +- 0.18 3 10

TIGR03885 (3/3) probable non-F420 flavinoid oxidoreductase
PF18306 (3/3) SLOG cluster4 family
PF16657 (3/3) Maltogenic Amylase, C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03641 (3/3) Possible lysine decarboxylase
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (3/3) Polysaccharide deacetylase
PF00553 (3/3) Cellulose binding domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00128 (3/3) Alpha amylase, catalytic domain
precursor_groups_184 88.98 +- 82.54 4 0 1 0 0.10 +- 0.16 4 4

PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF05988 (2/4) Bacterial protein of unknown function (DUF899)
PF03266 (2/4) NTPase
PF00501 (2/4) AMP-binding enzyme
precursor_groups_47519 246.55 +- 29.88 2 0 0 2 0.02 +- 0.00 2 5

PF13847 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
precursor_groups_32192 365.31 +- 284.69 2 0 0 0 0.03 +- 0.05 2 3

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase
precursor_groups_70951 379.29 +- 20.56 2 0 0 0 0.04 +- 0.09 2 15

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF14657 (2/2) Arm DNA-binding domain
PF13612 (2/2) Transposase DDE domain
PF13520 (2/2) Amino acid permease
PF13424 (2/2) Tetratricopeptide repeat
PF01636 (2/2) Phosphotransferase enzyme family
PF01381 (2/2) Helix-turn-helix
PF01225 (2/2) Mur ligase family, catalytic domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00589 (2/2) Phage integrase family
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00005 (2/2) ABC transporter
precursor_groups_73285 60.31 +- 29.11 2 0 0 0 0.15 +- 0.20 2 6

TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_groups_46844 124.66 +- 0.85 2 0 0 0 0.05 +- 0.06 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF04542 (2/2) Sigma-70 region 2
PF04264 (2/2) YceI-like domain
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF00890 (1/2) FAD binding domain
precursor_groups_77295 403.00 +- 247.00 2 0 0 0 0.02 +- 0.02 2 8

PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF01451 (1/2) Low molecular weight phosphotyrosine protein phosphatase
precursor_groups_66307 47.21 +- 8.51 2 0 2 0 0.04 +- 0.03 2 5

TIGR02601 (2/2) autotransporter-associated beta strand repeat
PF12951 (2/2) Passenger-associated-transport-repeat
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF01569 (2/2) PAP2 superfamily
PF01565 (2/2) FAD binding domain
precursor_groups_53018 332.22 +- 72.22 2 0 0 0 0.01 +- 0.00 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF03746 (2/2) LamB/YcsF family
PF02682 (2/2) Carboxyltransferase domain, subdomain C and D
PF02626 (2/2) Carboxyltransferase domain, subdomain A and B
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_57001 456.07 +- 52.62 2 0 0 0 0.01 +- 0.01 2 15

TIGR00364 (2/2) queuosine biosynthesis protein QueC
PF13692 (2/2) Glycosyl transferases group 1
PF13439 (2/2) Glycosyltransferase Family 4
PF13394 (2/2) 4Fe-4S single cluster domain
PF13242 (2/2) HAD-hyrolase-like
PF08889 (2/2) WbqC-like protein family
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF02739 (2/2) 5'-3' exonuclease, N-terminal resolvase-like domain
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01367 (2/2) 5'-3' exonuclease, C-terminal SAM fold
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00534 (2/2) Glycosyl transferases group 1
PF00156 (2/2) Phosphoribosyl transferase domain
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
precursor_groups_5224 994.22 +- 94.22 2 0 0 0 0.02 +- 0.02 2 14

TIGR04416 (2/2) group II intron reverse transcriptase/maturase
PF14759 (2/2) Reductase C-terminal
PF08388 (2/2) Group II intron, maturase-specific domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04213 (2/2) Htaa
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00665 (2/2) Integrase core domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00248 (2/2) Aldo/keto reductase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
PF00067 (2/2) Cytochrome P450
precursor_groups_76073 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 8

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_2208 205.86 +- 9.16 2 0 2 0 0.13 +- 0.25 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF13560 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF05977 (2/2) Transmembrane secretion effector
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/2) B12 binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00229 (1/2) PAS domain S-box protein
PF12802 (1/2) MarR family
PF08448 (1/2) PAS fold
PF07690 (1/2) Major Facilitator Superfamily
PF02274 (1/2) Amidinotransferase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_7811 197.04 +- 161.98 4 0 2 0 0.06 +- 0.15 4 8

PF18765 (2/4) Polymerase beta, Nucleotidyltransferase
PF09848 (2/4) Uncharacterized conserved protein (DUF2075)
PF07728 (2/4) AAA domain (dynein-related subfamily)
PF06236 (2/4) Tyrosinase co-factor MelC1
PF00857 (2/4) Isochorismatase family
PF00296 (2/4) Luciferase-like monooxygenase
PF00293 (2/4) NUDIX domain
PF00264 (2/4) Common central domain of tyrosinase
precursor_groups_21050 200.05 +- 54.78 5 0 5 0 0.02 +- 0.01 5 8

PF11639 (5/5) REDY-like protein HapK
PF03704 (5/5) Bacterial transcriptional activator domain
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_21053 211.11 +- 198.77 3 0 0 0 0.10 +- 0.12 3 5

PF14534 (3/3) Domain of unknown function (DUF4440)
PF08002 (3/3) Protein of unknown function (DUF1697)
PF01323 (3/3) DSBA-like thioredoxin domain
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_19969 631.52 +- 314.74 4 0 0 0 0.02 +- 0.01 4 5

PF08666 (4/4) SAF domain
PF07811 (4/4) TadE-like protein
PF01935 (4/4) Helicase HerA, central domain
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
precursor_groups_2202 40.24 +- 11.36 2 0 0 0 0.06 +- 0.08 2 8

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF16656 (2/2) Purple acid Phosphatase, N-terminal domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07971 (2/2) Glycosyl hydrolase family 92
PF01638 (2/2) HxlR-like helix-turn-helix
PF00149 (2/2) Calcineurin-like phosphoesterase
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
precursor_groups_57875 226.75 +- 33.25 2 0 0 0 0.01 +- 0.00 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13365 (2/2) Trypsin-like peptidase domain
PF13191 (2/2) AAA ATPase domain
PF10503 (2/2) Esterase PHB depolymerase
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_84352 2404.29 +- 175.71 2 0 2 0 0.01 +- 0.00 2 5

PF13463 (2/2) Winged helix DNA-binding domain
PF09084 (2/2) NMT1/THI5 like
PF04909 (2/2) Amidohydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_30449 331.75 +- 90.93 4 0 0 0 0.04 +- 0.04 4 14

TIGR02138 (4/4) phosphate ABC transporter, permease protein PstC
TIGR01076 (4/4) sortase
TIGR00974 (4/4) phosphate ABC transporter, permease protein PstA
TIGR00972 (4/4) phosphate ABC transporter, ATP-binding protein
PF18431 (4/4) Bacterial CdiA-CT RNAse A domain
PF16640 (4/4) Bacterial Ig-like domain (group 3)
PF12849 (4/4) PBP superfamily domain
PF06013 (4/4) Proteins of 100 residues with WXG
PF05908 (4/4) Poly-gamma-glutamate hydrolase
PF04203 (4/4) Sortase domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00005 (4/4) ABC transporter
PF18593 (3/4) CdiI immunity protein
PF00041 (3/4) Fibronectin type III domain
precursor_groups_3029 214.96 +- 102.76 4 0 4 0 0.04 +- 0.04 4 5

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01946 (3/4) Thi4 family
precursor_groups_33394 390.00 +- 130.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR03571 (2/2) luciferase-type oxidoreductase, BA3436 family
PF01613 (2/2) Flavin reductase like domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_65647 245.55 +- 107.80 2 0 0 0 0.04 +- 0.08 2 8

PF06722 (2/2) Protein of unknown function (DUF1205)
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01804 (2/2) Penicillin amidase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_30440 28.83 +- 7.08 3 0 0 0 0.16 +- 0.19 3 7

PF04016 (3/3) Putative heavy-metal chelation
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00288 (3/3) GHMP kinases N terminal domain
PF00005 (3/3) ABC transporter
PF00425 (2/3) chorismate binding enzyme
precursor_groups_30441 251.45 +- 195.83 4 0 0 0 0.03 +- 0.07 4 6

PF00082 (4/4) Subtilase family
TIGR03930 (3/4) WXG100 family type VII secretion target
PF06013 (3/4) Proteins of 100 residues with WXG
TIGR03921 (2/4) type VII secretion-associated serine protease mycosin
TIGR03919 (2/4) type VII secretion protein EccB
PF05108 (2/4) Type VII secretion system ESX-1, transport TM domain B
precursor_groups_36505 30.66 +- 3.29 2 0 0 2 0.13 +- 0.06 2 6

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05141 (2/2) Pyoverdine/dityrosine biosynthesis protein
PF00733 (2/2) Asparagine synthase
PF00067 (2/2) Cytochrome P450
precursor_groups_1122 339.24 +- 280.12 59 0 0 0 0.04 +- 0.02 59 11

TIGR01733 (59/59) amino acid adenylation domain
PF07859 (59/59) alpha/beta hydrolase fold
PF00583 (59/59) Acetyltransferase (GNAT) family
PF00501 (59/59) AMP-binding enzyme
PF11695 (57/59) Domain of unknown function (DUF3291)
PF09334 (57/59) tRNA synthetases class I (M)
PF07883 (57/59) Cupin domain
PF01494 (57/59) FAD binding domain
PF00581 (57/59) Rhodanese-like domain
PF01266 (55/59) FAD dependent oxidoreductase
PF13434 (54/59) L-lysine 6-monooxygenase (NADPH-requiring)
precursor_groups_2680 65.37 +- 39.59 3 0 3 0 0.20 +- 0.36 3 8

TIGR01051 (2/3) DNA topoisomerase I
PF13368 (2/3) Topoisomerase C-terminal repeat
PF07730 (2/3) Histidine kinase
PF01751 (2/3) Toprim domain
PF01131 (2/3) DNA topoisomerase
PF00561 (2/3) alpha/beta hydrolase fold
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
precursor_groups_56999 54.92 +- 12.70 2 0 0 0 0.08 +- 0.05 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF04828 (2/2) Glutathione-dependent formaldehyde-activating enzyme
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
precursor_groups_57460 85.97 +- 19.08 2 0 2 0 0.12 +- 0.20 2 9

TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13304 (2/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF08241 (2/2) Methyltransferase domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (2/2) ABC transporter
TIGR01426 (1/2) glycosyltransferase, MGT family
precursor_groups_19924 163.06 +- 52.11 3 0 0 0 0.13 +- 0.21 3 17

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF13796 (3/3) Putative sensor
PF12730 (3/3) ABC-2 family transporter protein
PF07730 (3/3) Histidine kinase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04444 (3/3) Catechol dioxygenase N terminus
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00775 (3/3) Dioxygenase
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_groups_30764 49.23 +- 20.12 3 0 0 0 0.11 +- 0.09 3 5

PF08220 (3/3) DeoR-like helix-turn-helix domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (3/3) DeoR C terminal sensor domain
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_250 52.32 +- 55.08 13 0 0 0 0.10 +- 0.13 13 6

PF13828 (13/13) Domain of unknown function (DUF4190)
PF09995 (12/13) Uncharacterized protein conserved in bacteria (DUF2236)
PF01738 (12/13) Dienelactone hydrolase family
TIGR00879 (11/13) MFS transporter, sugar porter (SP) family
PF05721 (11/13) Phytanoyl-CoA dioxygenase (PhyH)
PF00083 (11/13) Sugar (and other) transporter
precursor_groups_251 52.04 +- 66.64 4 0 1 0 0.15 +- 0.20 4 5

TIGR03802 (2/4) aspartate-alanine antiporter
TIGR03801 (2/4) aspartate 4-decarboxylase
PF06826 (2/4) Predicted Permease Membrane Region
PF02080 (2/4) TrkA-C domain
PF00155 (2/4) Aminotransferase class I and II
precursor_groups_13095 280.59 +- 151.56 3 0 0 0 0.07 +- 0.06 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF17851 (2/3) Beta xylosidase C-terminal Concanavalin A-like domain
precursor_groups_13764 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family
precursor_groups_257 185.72 +- 297.20 7 0 0 1 0.17 +- 0.23 7 1

PF00005 (4/7) ABC transporter
precursor_groups_29445 148.89 +- 70.74 3 0 3 0 0.07 +- 0.10 3 17

TIGR03217 (3/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (3/3) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (3/3) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (3/3) 3-hydroxyanthranilate 3,4-dioxygenase
TIGR01814 (3/3) kynureninase
PF09290 (3/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08309 (3/3) LVIVD repeat
PF07836 (3/3) DmpG-like communication domain
PF06052 (3/3) 3-hydroxyanthranilic acid dioxygenase
PF04909 (3/3) Amidohydrolase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (3/3) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (3/3) Endoribonuclease L-PSP
PF00682 (3/3) HMGL-like
PF00324 (3/3) Amino acid permease
PF00266 (3/3) Aminotransferase class-V
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_72006 113.76 +- 24.10 2 0 0 0 0.18 +- 0.31 2 5

PF05995 (2/2) Cysteine dioxygenase type I
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_812 93.82 +- 51.13 3 0 2 0 0.05 +- 0.09 3 8

PF13564 (2/3) DoxX-like family
PF12680 (2/3) SnoaL-like domain
PF08843 (2/3) Nucleotidyl transferase AbiEii toxin, Type IV TA system
PF06441 (2/3) Epoxide hydrolase N terminus
PF03413 (2/3) Peptidase propeptide and YPEB domain
PF01810 (2/3) LysE type translocator
PF00561 (2/3) alpha/beta hydrolase fold
PF00067 (2/3) Cytochrome P450
precursor_groups_74840 42.17 +- 14.56 2 0 2 0 0.11 +- 0.20 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF05834 (2/2) Lycopene cyclase protein
PF02082 (2/2) Transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
precursor_groups_810 160.96 +- 99.04 2 0 1 0 0.04 +- 0.06 2 10

TIGR03559 (1/2) probable F420-dependent oxidoreductase, Rv3520c family
TIGR00876 (1/2) transaldolase
TIGR00232 (1/2) transketolase
PF18313 (1/2) Thiolase-like protein type 1 additional C-terminal domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_17734 166.55 +- 19.12 5 0 2 0 0.04 +- 0.02 5 4

PF13377 (5/5) Periplasmic binding protein-like domain
PF05199 (5/5) GMC oxidoreductase
PF00732 (5/5) GMC oxidoreductase
PF00356 (5/5) Bacterial regulatory proteins, lacI family
precursor_groups_75740 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_groups_29141 1164.00 +- 4.24 3 0 3 0 0.01 +- 0.00 3 5

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_groups_819 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_groups_75746 113.94 +- 23.94 2 0 0 0 0.04 +- 0.02 2 7

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF00698 (1/2) Acyl transferase domain
precursor_groups_19588 95.56 +- 47.30 3 0 0 0 0.03 +- 0.04 3 3

PF02515 (3/3) CoA-transferase family III
PF00082 (3/3) Subtilase family
PF05425 (2/3) Copper resistance protein D
precursor_groups_19589 54.24 +- 26.38 2 0 0 0 0.06 +- 0.05 2 6

TIGR00369 (2/2) uncharacterized domain 1
PF03061 (2/2) Thioesterase superfamily
PF00857 (1/2) Isochorismatase family
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_66343 132.74 +- 40.60 2 0 2 0 0.04 +- 0.05 2 8

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (2/2) benzoate transporter
PF13454 (2/2) FAD-NAD(P)-binding
PF03594 (2/2) Benzoate membrane transport protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_53747 730.56 +- 559.44 2 0 1 0 0.07 +- 0.16 2 16

TIGR04458 (2/2) 4-nitrotryptophan synthase
TIGR00730 (2/2) TIGR00730 family protein
PF13649 (2/2) Methyltransferase domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF02898 (2/2) Nitric oxide synthase, oxygenase domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01745 (2/2) Isopentenyl transferase
PF01565 (2/2) FAD binding domain
PF00872 (2/2) Transposase, Mutator family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_52691 175.99 +- 57.04 2 0 2 2 0.09 +- 0.18 2 22

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF11188 (2/2) Protein of unknown function (DUF2975)
PF08592 (2/2) Domain of unknown function (DUF1772)
PF07883 (2/2) Cupin domain
PF04673 (2/2) Polyketide synthesis cyclase
PF04672 (2/2) S-adenosyl methyltransferase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03704 (2/2) Bacterial transcriptional activator domain
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01850 (2/2) PIN domain
PF00931 (2/2) NB-ARC domain
PF00854 (2/2) POT family
PF00733 (2/2) Asparagine synthase
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_19856 533.76 +- 91.96 5 0 5 0 0.01 +- 0.00 5 6

PF13640 (5/5) 2OG-Fe(II) oxygenase superfamily
PF13350 (5/5) Tyrosine phosphatase family
PF07690 (5/5) Major Facilitator Superfamily
PF01142 (5/5) tRNA pseudouridine synthase D (TruD)
PF00275 (5/5) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00106 (5/5) short chain dehydrogenase
precursor_groups_9062 21.67 +- 6.75 9 0 9 0 0.17 +- 0.05 9 3

PF17851 (9/9) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (9/9) Glycosyl hydrolases family 43
PF00106 (9/9) short chain dehydrogenase
precursor_groups_13163 1326.22 +- 281.32 2 0 0 0 0.01 +- 0.01 2 15

TIGR02960 (2/2) RNA polymerase sigma-70 factor, TIGR02960 family
PF14330 (2/2) Domain of unknown function (DUF4387)
PF08281 (2/2) Sigma-70, region 4
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF07287 (2/2) Acyclic terpene utilisation family protein AtuA
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01872 (2/2) RibD C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_460 1330.00 +- 1250.00 2 0 1 1 0.02 +- 0.02 2 8

PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF05139 (1/2) Erythromycin esterase
PF02384 (1/2) N-6 DNA Methylase
PF01420 (1/2) Type I restriction modification DNA specificity domain
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00089 (1/2) Trypsin
precursor_groups_52761 142.41 +- 72.76 2 0 2 0 0.06 +- 0.04 2 5

PF13833 (2/2) EF-hand domain pair
PF13499 (2/2) EF-hand domain pair
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07969 (2/2) Amidohydrolase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_24868 22.40 +- 8.07 2 0 0 0 0.12 +- 0.16 2 4

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF00501 (1/2) AMP-binding enzyme
precursor_groups_38581 2382.31 +- 1144.08 3 0 0 0 0.03 +- 0.10 3 20

TIGR01179 (3/3) UDP-glucose 4-epimerase GalE
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13692 (3/3) Glycosyl transferases group 1
PF13489 (3/3) Methyltransferase domain
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF12708 (3/3) Pectate lyase superfamily protein
PF07883 (3/3) Cupin domain
PF04101 (3/3) Glycosyltransferase family 28 C-terminal domain
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02566 (3/3) OsmC-like protein
PF01979 (3/3) Amidohydrolase family
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00664 (3/3) ABC transporter transmembrane region
PF00155 (3/3) Aminotransferase class I and II
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
PF13641 (2/3) Glycosyltransferase like family 2
PF03704 (2/3) Bacterial transcriptional activator domain
PF00486 (2/3) Transcriptional regulatory protein, C terminal
precursor_groups_39821 454.71 +- 299.58 3 0 1 0 0.06 +- 0.12 3 18

PF17677 (3/3) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (3/3) Alpha mannosidase middle domain
PF07748 (3/3) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (3/3) Trehalose utilisation
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (3/3) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF13412 (2/3) Winged helix-turn-helix DNA-binding
PF12840 (2/3) Helix-turn-helix domain
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/3) Acyl transferase domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00480 (2/3) ROK family
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1267 32.73 +- 13.49 28 0 26 0 0.15 +- 0.19 28 9

PF03450 (27/28) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (27/28) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (27/28) [2Fe-2S] binding domain
PF01315 (27/28) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (27/28) FAD binding domain in molybdopterin dehydrogenase
PF00111 (27/28) 2Fe-2S iron-sulfur cluster binding domain
PF09856 (15/28) Predicted transcriptional regulator (DUF2083)
PF06114 (15/28) IrrE N-terminal-like domain
PF01381 (15/28) Helix-turn-helix
precursor_groups_35757 569.52 +- 70.04 3 0 3 3 0.01 +- 0.01 3 5

PF13454 (3/3) FAD-NAD(P)-binding
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_35755 55.61 +- 3.48 2 0 2 0 0.22 +- 0.39 2 10

PF13407 (2/2) Periplasmic binding protein domain
PF12802 (2/2) MarR family
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00550 (2/2) Phosphopantetheine attachment site
PF00480 (2/2) ROK family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_2333 152.65 +- 97.27 3 0 2 0 0.09 +- 0.28 3

No common domains found
precursor_groups_65794 223.33 +- 136.67 2 0 1 0 0.02 +- 0.01 2 5

TIGR00345 (2/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF02554 (2/2) Carbon starvation protein CstA
PF02374 (2/2) Anion-transporting ATPase
PF04672 (1/2) S-adenosyl methyltransferase
precursor_groups_38038 523.88 +- 323.32 3 0 2 0 0.03 +- 0.02 3 10

PF13450 (2/3) NAD(P)-binding Rossmann-like domain
PF07730 (2/3) Histidine kinase
PF07690 (2/3) Major Facilitator Superfamily
PF05721 (2/3) Phytanoyl-CoA dioxygenase (PhyH)
PF03936 (2/3) Terpene synthase family, metal binding domain
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02401 (2/3) LytB protein
PF00348 (2/3) Polyprenyl synthetase
PF00106 (2/3) short chain dehydrogenase
PF00067 (2/3) Cytochrome P450
precursor_groups_22715 214.88 +- 32.48 3 0 2 0 0.11 +- 0.30 3 11

TIGR01733 (2/3) amino acid adenylation domain
PF13649 (2/3) Methyltransferase domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_18459 556.36 +- 312.83 6 0 0 0 0.03 +- 0.10 6 7

PF13185 (6/6) GAF domain
PF12833 (6/6) Helix-turn-helix domain
PF09056 (6/6) Prokaryotic phospholipase A2
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF01965 (6/6) DJ-1/PfpI family
PF01483 (6/6) Proprotein convertase P-domain
PF00082 (6/6) Subtilase family
precursor_groups_39526 282.67 +- 79.50 3 0 2 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01180 (3/3) Dihydroorotate dehydrogenase
precursor_groups_85407 1529.06 +- 164.06 2 0 2 2 0.01 +- 0.00 2 12

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04072 (2/2) Leucine carboxyl methyltransferase
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02441 (2/2) Flavoprotein
PF02195 (2/2) ParB-like nuclease domain
PF00881 (2/2) Nitroreductase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF06779 (1/2) Uncharacterised MFS-type transporter YbfB
precursor_groups_13616 412.80 +- 103.20 2 0 2 2 0.01 +- 0.00 2 2

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00069 (2/2) Protein kinase domain
precursor_groups_18456 298.54 +- 60.97 6 0 0 0 0.03 +- 0.02 6 7

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF08666 (6/6) SAF domain
PF07811 (6/6) TadE-like protein
PF03704 (6/6) Bacterial transcriptional activator domain
PF01476 (6/6) LysM domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_groups_12386 161.77 +- 52.50 8 0 0 0 0.07 +- 0.08 8 6

PF09362 (8/8) Domain of unknown function (DUF1996)
PF03713 (8/8) Domain of unknown function (DUF305)
PF02861 (8/8) Clp amino terminal domain, pathogenicity island component
PF01061 (8/8) ABC-2 type transporter
PF00005 (8/8) ABC transporter
PF00754 (6/8) F5/8 type C domain
precursor_groups_22719 194.17 +- 27.47 4 0 4 0 0.15 +- 0.29 4 27

TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01426 (4/4) glycosyltransferase, MGT family
TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (4/4) Domain of unknown function (DUF4162)
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF12697 (4/4) Alpha/beta hydrolase family
PF07977 (4/4) FabA-like domain
PF03109 (4/4) ABC1 family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02635 (4/4) DsrE/DsrF-like family
PF01593 (4/4) Flavin containing amine oxidoreductase
PF01323 (4/4) DSBA-like thioredoxin domain
PF01061 (4/4) ABC-2 type transporter
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
TIGR01720 (3/4) non-ribosomal peptide synthase domain TIGR01720
TIGR00747 (3/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (3/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
precursor_groups_42690 78.76 +- 24.44 2 0 2 0 0.06 +- 0.05 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13361 (2/2) UvrD-like helicase C-terminal domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00069 (2/2) Protein kinase domain
precursor_groups_24931 256.07 +- 76.34 4 0 0 0 0.02 +- 0.01 4 2

PF01757 (4/4) Acyltransferase family
PF01522 (4/4) Polysaccharide deacetylase
precursor_groups_42695 171.89 +- 62.82 3 0 3 0 0.11 +- 0.23 3 11

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13822 (3/3) Acyl-CoA carboxylase epsilon subunit
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00072 (3/3) Response regulator receiver domain
precursor_groups_83901 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_62442 62.70 +- 14.83 2 0 0 1 0.22 +- 0.33 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
PF13360 (1/2) PQQ-like domain
precursor_groups_18291 16.70 +- 2.04 4 0 0 4 0.20 +- 0.12 4 3

PF13360 (4/4) PQQ-like domain
PF11575 (4/4) FhuF 2Fe-2S C-terminal domain
PF00069 (4/4) Protein kinase domain
precursor_groups_77396 130.00 +- 0.00 2 0 2 0 0.02 +- 0.00 2 3

PF16864 (2/2) Dimerisation domain
PF00891 (2/2) O-methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_73425 72.50 +- 12.83 2 0 0 0 0.17 +- 0.30 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00630 (2/2) excinuclease ABC subunit A
PF17760 (2/2) UvrA interaction domain
PF17755 (2/2) UvrA DNA-binding domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13280 (2/2) WYL domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF00140 (2/2) Sigma-70 factor, region 1.2
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_groups_28925 217.92 +- 132.08 2 0 0 0 0.04 +- 0.09 2 9

PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07681 (2/2) DoxX
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_77707 72.19 +- 21.63 2 0 0 0 0.17 +- 0.28 2 17

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03567 (2/2) FMN reductase
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03358 (2/2) NADPH-dependent FMN reductase
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00483 (2/2) Nucleotidyl transferase
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_61894 113.18 +- 42.82 2 0 0 0 0.06 +- 0.06 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF05141 (2/2) Pyoverdine/dityrosine biosynthesis protein
PF00067 (2/2) Cytochrome P450
PF12833 (1/2) Helix-turn-helix domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_18859 9.92 +- 0.40 2 0 0 0 0.20 +- 0.28 2 2

PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_25534 16.27 +- 0.21 3 0 0 0 0.25 +- 0.38 3 7

TIGR01525 (3/3) heavy metal translocating P-type ATPase
PF12697 (3/3) Alpha/beta hydrolase family
PF03965 (3/3) Penicillinase repressor
PF01435 (3/3) Peptidase family M48
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
precursor_groups_38922 308.15 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

PF18631 (2/2) Cucumopine synthase C-terminal helical bundle domain
PF13546 (2/2) DDE superfamily endonuclease
PF02195 (2/2) ParB-like nuclease domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_52507 134.01 +- 78.72 2 0 2 2 0.06 +- 0.05 2 9

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat
precursor_groups_42215 42.86 +- 0.47 2 0 0 0 0.07 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF07730 (2/2) Histidine kinase
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
PF00072 (2/2) Response regulator receiver domain
precursor_groups_66914 315.51 +- 38.59 2 0 0 0 0.22 +- 0.22 2 20

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (2/2) FMN reductase
TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00738 (2/2) Rrf2 family protein
PF13410 (2/2) Glutathione S-transferase, C-terminal domain
PF13187 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF08445 (2/2) FR47-like protein
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02082 (2/2) Transcriptional regulator
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_43613 30.51 +- 6.01 3 0 0 0 0.07 +- 0.04 3 2

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (3/3) Luciferase-like monooxygenase
precursor_groups_12417 207.27 +- 160.94 7 0 7 0 0.13 +- 0.25 7 19

TIGR02980 (7/7) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
TIGR01733 (7/7) amino acid adenylation domain
TIGR01720 (7/7) non-ribosomal peptide synthase domain TIGR01720
PF17196 (7/7) Protein of unknown function (DUF5133)
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12401 (7/7) Protein of unknown function (DUF2662)
PF04545 (7/7) Sigma-70, region 4
PF04542 (7/7) Sigma-70 region 2
PF04539 (7/7) Sigma-70 region 3
PF02518 (7/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01061 (7/7) ABC-2 type transporter
PF00672 (7/7) HAMP domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00512 (7/7) His Kinase A (phospho-acceptor) domain
PF00501 (7/7) AMP-binding enzyme
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00072 (7/7) Response regulator receiver domain
PF00005 (7/7) ABC transporter
precursor_groups_2029 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_10680 39.13 +- 21.93 2 0 0 0 0.15 +- 0.16 2 9

PF00583 (2/2) Acetyltransferase (GNAT) family
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13671 (1/2) AAA domain
PF03404 (1/2) Mo-co oxidoreductase dimerisation domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00174 (1/2) Oxidoreductase molybdopterin binding domain
PF00005 (1/2) ABC transporter
precursor_groups_20092 694.36 +- 239.48 4 0 4 0 0.03 +- 0.03 4 26

TIGR01733 (4/4) amino acid adenylation domain
PF18563 (4/4) TubC N-terminal docking domain
PF16653 (4/4) Saccharopine dehydrogenase C-terminal domain
PF14518 (4/4) Iron-containing redox enzyme
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF13535 (4/4) ATP-grasp domain
PF13434 (4/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF09334 (4/4) tRNA synthetases class I (M)
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF05222 (4/4) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (4/4) Saccharopine dehydrogenase NADP binding domain
PF03417 (4/4) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01266 (4/4) FAD dependent oxidoreductase
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (3/4) Cytochrome P450
precursor_groups_10528 271.27 +- 101.13 8 0 0 0 0.04 +- 0.08 8 7

PF13649 (8/8) Methyltransferase domain
PF13520 (8/8) Amino acid permease
PF02668 (8/8) Taurine catabolism dioxygenase TauD, TfdA family
PF01636 (8/8) Phosphotransferase enzyme family
PF00293 (8/8) NUDIX domain
PF00120 (8/8) Glutamine synthetase, catalytic domain
PF00005 (8/8) ABC transporter
precursor_groups_81224 48.24 +- 18.38 2 0 0 0 0.16 +- 0.08 2 8

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13692 (2/2) Glycosyl transferases group 1
PF12138 (2/2) Spherulation-specific family 4
PF11997 (2/2) Domain of unknown function (DUF3492)
PF03537 (2/2) Glycoside-hydrolase family GH114
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00483 (2/2) Nucleotidyl transferase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_16266 47.86 +- 30.14 2 0 0 0 0.10 +- 0.18 2 5

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF03606 (2/2) C4-dicarboxylate anaerobic carrier
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_266 209.11 +- 180.89 2 0 1 0 0.13 +- 0.14 2 14

TIGR01891 (1/2) amidohydrolase
PF16952 (1/2) Glutamine synthetase N-terminal domain
PF16262 (1/2) Domain of unknown function (DUF4916)
PF13185 (1/2) GAF domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05231 (1/2) MASE1
PF05199 (1/2) GMC oxidoreductase
PF04909 (1/2) Amidohydrolase
PF04672 (1/2) S-adenosyl methyltransferase
PF03988 (1/2) Repeat of Unknown Function (DUF347)
PF01546 (1/2) Peptidase family M20/M25/M40
PF00732 (1/2) GMC oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00120 (1/2) Glutamine synthetase, catalytic domain
precursor_groups_60206 60.31 +- 19.69 2 0 0 0 0.07 +- 0.04 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_groups_74234 35.12 +- 3.90 2 0 0 0 0.20 +- 0.33 2 13

TIGR02133 (2/2) ribose 5-phosphate isomerase
TIGR00232 (2/2) transketolase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00121 (2/2) Triosephosphate isomerase
precursor_groups_74230 93.40 +- 12.15 2 0 0 0 0.03 +- 0.05 2 6

TIGR03510 (2/2) XapX domain
PF12802 (2/2) MarR family
PF07883 (2/2) Cupin domain
PF07859 (2/2) alpha/beta hydrolase fold
PF07235 (2/2) Protein of unknown function (DUF1427)
PF04909 (2/2) Amidohydrolase
precursor_groups_3003 138.20 +- 111.30 2 0 1 0 0.17 +- 0.19 2 18

TIGR01728 (1/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF16347 (1/2) Domain of unknown function (DUF4976)
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF13203 (1/2) Putative metallopeptidase domain
PF11991 (1/2) Tryptophan dimethylallyltransferase
PF09967 (1/2) VWA-like domain (DUF2201)
PF09084 (1/2) NMT1/THI5 like
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF05331 (1/2) Protein of unknown function (DUF742)
PF04909 (1/2) Amidohydrolase
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF01212 (1/2) Beta-eliminating lyase
PF00884 (1/2) Sulfatase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00480 (1/2) ROK family
PF00005 (1/2) ABC transporter
precursor_groups_6030 96.06 +- 65.98 8 0 0 0 0.03 +- 0.03 8 3

PF01068 (8/8) ATP dependent DNA ligase domain
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00106 (8/8) short chain dehydrogenase
precursor_groups_78418 670.50 +- 103.50 2 0 0 0 0.04 +- 0.04 2 7

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF01850 (2/2) PIN domain
PF00361 (2/2) Proton-conducting membrane transporter
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00146 (1/2) NADH dehydrogenase
precursor_groups_2049 1036.00 +- 4.00 2 0 0 0 0.01 +- 0.00 2 6

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_17100 342.72 +- 122.82 4 0 0 0 0.03 +- 0.03 4 8

PF14525 (4/4) AraC-binding-like domain
PF12833 (4/4) Helix-turn-helix domain
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF02909 (4/4) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_groups_18189 647.50 +- 2.50 6 0 6 0 0.01 +- 0.00 6 11

PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02812 (6/6) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00856 (6/6) SET domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00208 (6/6) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_52435 1163.94 +- 693.66 2 0 0 0 0.02 +- 0.01 2 18

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_42362 2762.67 +- 988.06 3 0 3 0 0.01 +- 0.00 3 13

TIGR03297 (3/3) phosphonopyruvate decarboxylase
TIGR00045 (3/3) glycerate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF02595 (3/3) Glycerate kinase family
PF01061 (3/3) ABC-2 type transporter
PF00696 (3/3) Amino acid kinase family
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00266 (3/3) Aminotransferase class-V
PF00005 (3/3) ABC transporter
precursor_groups_55427 120.74 +- 20.74 2 0 0 0 0.08 +- 0.11 2 14

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF13613 (1/2) Helix-turn-helix of DDE superfamily endonuclease
PF04828 (1/2) Glutathione-dependent formaldehyde-activating enzyme
PF01609 (1/2) Transposase DDE domain
precursor_groups_6328 168.44 +- 128.63 10 0 2 0 0.15 +- 0.08 10 18

PF14310 (10/10) Fibronectin type III-like domain
PF13377 (10/10) Periplasmic binding protein-like domain
PF09084 (10/10) NMT1/THI5 like
PF01915 (10/10) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF00933 (10/10) Glycosyl hydrolase family 3 N terminal domain
PF00753 (10/10) Metallo-beta-lactamase superfamily
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00356 (10/10) Bacterial regulatory proteins, lacI family
PF00150 (10/10) Cellulase (glycosyl hydrolase family 5)
PF00135 (10/10) Carboxylesterase family
PF00005 (10/10) ABC transporter
PF16197 (7/10) Ketoacyl-synthetase C-terminal extension
PF02801 (7/10) Beta-ketoacyl synthase, C-terminal domain
PF01370 (7/10) NAD dependent epimerase/dehydratase family
PF00155 (7/10) Aminotransferase class I and II
PF00109 (7/10) Beta-ketoacyl synthase, N-terminal domain
PF00067 (7/10) Cytochrome P450
precursor_groups_6459 366.73 +- 1.84 2 0 0 0 0.03 +- 0.02 2 12

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF05977 (2/2) Transmembrane secretion effector
PF05199 (2/2) GMC oxidoreductase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF14013 (1/2) MT0933-like antitoxin protein
PF03707 (1/2) Bacterial signalling protein N terminal repeat
PF00135 (1/2) Carboxylesterase family
precursor_groups_6456 45.03 +- 12.22 2 0 0 0 0.10 +- 0.07 2 11

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13361 (2/2) UvrD-like helicase C-terminal domain
PF13245 (2/2) AAA domain
PF12833 (2/2) Helix-turn-helix domain
PF05593 (2/2) RHS Repeat
PF04264 (2/2) YceI-like domain
PF03527 (2/2) RHS protein
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00069 (2/2) Protein kinase domain
precursor_groups_68571 24.72 +- 1.08 2 0 0 0 0.08 +- 0.08 2 4

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
precursor_groups_67782 182.00 +- 52.00 2 0 0 0 0.02 +- 0.01 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF03928 (2/2) Haem-degrading
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_68779 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_406 718.71 +- 571.29 2 0 0 0 0.04 +- 0.04 2 16

PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
TIGR02089 (1/2) tartrate dehydrogenase
TIGR01428 (1/2) haloacid dehalogenase, type II
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF08402 (1/2) TOBE domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03466 (1/2) LysR substrate binding domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF01494 (1/2) FAD binding domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01042 (1/2) Endoribonuclease L-PSP
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_22155 411.72 +- 250.74 3 0 0 0 0.03 +- 0.12 3 8

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF03319 (3/3) Ethanolamine utilisation protein EutN/carboxysome
PF01636 (3/3) Phosphotransferase enzyme family
PF00936 (3/3) BMC domain
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
PF07702 (2/3) UTRA domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_groups_22154 1661.04 +- 262.74 4 0 2 4 0.01 +- 0.01 4 11

TIGR00702 (4/4) YcaO-type kinase domain
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF08007 (4/4) Cupin superfamily protein
PF07812 (4/4) TfuA-like protein
PF07690 (4/4) Major Facilitator Superfamily
PF05193 (4/4) Peptidase M16 inactive domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (4/4) Aminoglycoside 3-N-acetyltransferase
PF00675 (4/4) Insulinase (Peptidase family M16)
PF00326 (4/4) Prolyl oligopeptidase family
PF13349 (2/4) Putative adhesin
precursor_groups_1646 73.81 +- 58.18 13 0 0 0 0.12 +- 0.12 13 4

PF08007 (13/13) Cupin superfamily protein
PF06999 (13/13) Sucrase/ferredoxin-like
PF01184 (10/13) GPR1/FUN34/yaaH family
PF18029 (7/13) Glyoxalase-like domain
precursor_groups_16066 376.50 +- 233.17 4 0 4 0 0.03 +- 0.04 4 5

TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
PF01757 (4/4) Acyltransferase family
PF01061 (4/4) ABC-2 type transporter
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_groups_16067 490.44 +- 25.62 6 0 6 6 0.01 +- 0.00 6 6

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00685 (6/6) Sulfotransferase domain
PF00005 (6/6) ABC transporter
precursor_groups_16063 579.93 +- 757.51 3 0 3 1 0.03 +- 0.04 3 9

TIGR01733 (3/3) amino acid adenylation domain
TIGR00709 (3/3) 2,4-diaminobutyrate 4-transaminase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00202 (3/3) Aminotransferase class-III
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_groups_45903 249.94 +- 61.67 3 0 0 0 0.05 +- 0.12 3 10

PF13641 (3/3) Glycosyltransferase like family 2
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF00925 (3/3) GTP cyclohydrolase II
PF13802 (2/3) Galactose mutarotase-like
PF13570 (2/3) PQQ-like domain
PF06182 (2/3) ABC-2 family transporter protein
PF01055 (2/3) Glycosyl hydrolases family 31
PF00400 (2/3) WD domain, G-beta repeat
PF00356 (2/3) Bacterial regulatory proteins, lacI family
PF00005 (2/3) ABC transporter
precursor_groups_34524 598.93 +- 46.07 2 0 0 0 0.04 +- 0.01 2 5

PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
precursor_groups_3483 24.89 +- 12.22 6 0 0 0 0.15 +- 0.24 6 7

TIGR03696 (6/6) RHS repeat-associated core domain
TIGR01643 (6/6) YD repeat (two copies)
PF15657 (6/6) HNH/Endo VII superfamily nuclease toxins
PF13641 (6/6) Glycosyltransferase like family 2
PF05593 (6/6) RHS Repeat
PF01757 (6/6) Acyltransferase family
PF01522 (6/6) Polysaccharide deacetylase
precursor_groups_10707 221.77 +- 79.53 9 0 0 0 0.05 +- 0.04 9 10

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_groups_61513 23.32 +- 3.77 2 0 0 0 0.18 +- 0.13 2 7

TIGR01048 (2/2) diaminopimelate decarboxylase
TIGR00247 (2/2) conserved hypothetical protein, YceG family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02618 (2/2) YceG-like family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_10708 124.35 +- 31.34 3 0 0 0 0.19 +- 0.26 3 19

TIGR03356 (3/3) beta-galactosidase
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13527 (3/3) Acetyltransferase (GNAT) domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF12911 (3/3) N-terminal TM domain of oligopeptide transport permease C
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (3/3) Carbohydrate binding domain (family 11)
PF02983 (3/3) Alpha-lytic protease prodomain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00232 (3/3) Glycosyl hydrolase family 1
PF00005 (3/3) ABC transporter
TIGR00977 (2/3) citramalate synthase
PF08502 (2/3) LeuA allosteric (dimerisation) domain
PF03160 (2/3) Calx-beta domain
PF00682 (2/3) HMGL-like
precursor_groups_78704 387.00 +- 129.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR00654 (2/2) phenazine biosynthesis protein, PhzF family
PF02567 (2/2) Phenazine biosynthesis-like protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
precursor_groups_66785 3900.00 +- 780.00 2 0 2 2 0.01 +- 0.00 2 10

TIGR04267 (2/2) HEXXH motif domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF13535 (2/2) ATP-grasp domain
PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
precursor_groups_1381 195.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF13191 (2/2) AAA ATPase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_111 60.71 +- 42.79 54 0 6 4 0.10 +- 0.21 54

No common domains found
precursor_groups_7499 47.93 +- 14.79 3 0 0 0 0.17 +- 0.29 3 10

TIGR01361 (3/3) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (3/3) DAHP synthase ferredoxin-like domain
PF08031 (3/3) Berberine and berberine like
PF07883 (3/3) Cupin domain
PF01565 (3/3) FAD binding domain
PF01494 (3/3) FAD binding domain
PF00793 (3/3) DAHP synthetase I family
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF07690 (2/3) Major Facilitator Superfamily
precursor_groups_3311 209.31 +- 177.69 2 0 0 0 0.12 +- 0.25 2 11

PF00999 (2/2) Sodium/hydrogen exchanger family
PF00583 (2/2) Acetyltransferase (GNAT) family
TIGR01048 (1/2) diaminopimelate decarboxylase
PF13833 (1/2) EF-hand domain pair
PF13499 (1/2) EF-hand domain pair
PF10127 (1/2) RNA repair pathway DNA polymerase beta family
PF08281 (1/2) Sigma-70, region 4
PF06108 (1/2) Protein of unknown function (DUF952)
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00122 (1/2) E1-E2 ATPase
precursor_groups_3024 72.56 +- 23.85 2 0 2 0 0.25 +- 0.29 2 9

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF07350 (1/2) Protein of unknown function (DUF1479)
PF00278 (1/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
precursor_groups_69950 411.41 +- 362.59 2 0 0 0 0.07 +- 0.17 2 11

TIGR00673 (2/2) cyanase
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF09587 (2/2) Bacterial capsule synthesis protein PGA_cap
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01565 (2/2) FAD binding domain
PF00899 (2/2) ThiF family
PF00206 (2/2) Lyase
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_groups_7325 89.96 +- 17.78 3 0 0 0 0.03 +- 0.02 3 3

TIGR01428 (3/3) haloacid dehalogenase, type II
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF01266 (3/3) FAD dependent oxidoreductase
precursor_groups_7320 53.91 +- 8.85 7 0 0 0 0.19 +- 0.14 7 13

PF16353 (7/7) Domain of unknown function(DUF4981)
PF04030 (7/7) D-arabinono-1,4-lactone oxidase
PF02929 (7/7) Beta galactosidase small chain
PF02837 (7/7) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (7/7) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (7/7) FAD binding domain
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00480 (7/7) ROK family
PF13412 (6/7) Winged helix-turn-helix DNA-binding
PF13305 (5/7) Tetracyclin repressor-like, C-terminal domain
PF01547 (5/7) Bacterial extracellular solute-binding protein
PF01419 (5/7) Jacalin-like lectin domain
PF00440 (5/7) Bacterial regulatory proteins, tetR family
precursor_groups_11149 38.23 +- 32.58 4 0 0 0 0.08 +- 0.12 4 5

TIGR00546 (4/4) apolipoprotein N-acyltransferase
PF13577 (4/4) SnoaL-like domain
PF01794 (4/4) Ferric reductase like transmembrane component
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00582 (4/4) Universal stress protein family
precursor_groups_71148 958.83 +- 86.57 2 0 0 0 0.07 +- 0.20 2 29

PF18565 (2/2) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (2/2) Domain of unknown function (DUF4982)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13229 (2/2) Right handed beta helix region
PF12740 (2/2) Chlorophyllase enzyme
PF07859 (2/2) alpha/beta hydrolase fold
PF07745 (2/2) Glycosyl hydrolase family 53
PF07730 (2/2) Histidine kinase
PF07532 (2/2) Bacterial Ig-like domain (group 4)
PF04616 (2/2) Glycosyl hydrolases family 43
PF03737 (2/2) Aldolase/RraA
PF03422 (2/2) Carbohydrate binding module (family 6)
PF03176 (2/2) MMPL family
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01558 (2/2) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_29716 142.42 +- 22.33 4 0 4 0 0.06 +- 0.17 4 19

TIGR02412 (4/4) aminopeptidase N
TIGR01686 (4/4) FkbH domain
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13535 (4/4) ATP-grasp domain
PF13434 (4/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (4/4) ERAP1-like C-terminal domain
PF09334 (4/4) tRNA synthetases class I (M)
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF02274 (4/4) Amidinotransferase
PF02195 (4/4) ParB-like nuclease domain
PF01433 (4/4) Peptidase family M1 domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00999 (4/4) Sodium/hydrogen exchanger family
PF00550 (4/4) Phosphopantetheine attachment site
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_groups_12360 25.34 +- 6.76 6 0 0 0 0.16 +- 0.12 6 18

TIGR03346 (6/6) ATP-dependent chaperone protein ClpB
TIGR02350 (6/6) chaperone protein DnaK
PF17871 (6/6) AAA lid domain
PF10431 (6/6) C-terminal, D2-small domain, of ClpB protein
PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (6/6) AAA domain (Cdc48 subfamily)
PF02861 (6/6) Clp amino terminal domain, pathogenicity island component
PF02148 (6/6) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (6/6) DnaJ C terminal domain
PF01025 (6/6) GrpE
PF00226 (6/6) DnaJ domain
PF00085 (6/6) Thioredoxin
PF00027 (6/6) Cyclic nucleotide-binding domain
PF00012 (6/6) Hsp70 protein
PF00004 (6/6) ATPase family associated with various cellular activities (AAA)
TIGR01068 (5/6) thioredoxin
PF13591 (5/6) MerR HTH family regulatory protein
PF00011 (5/6) Hsp20/alpha crystallin family
precursor_groups_31875 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_68315 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_1938 16.13 +- 3.55 2 0 0 0 0.20 +- 0.09 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_3023 118.85 +- 181.45 11 0 0 0 0.12 +- 0.14 11 2

PF01145 (11/11) SPFH domain / Band 7 family
PF03067 (10/11) Lytic polysaccharide mono-oxygenase, cellulose-degrading
precursor_groups_49075 116.24 +- 12.76 2 0 0 0 0.12 +- 0.18 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
PF13577 (1/2) SnoaL-like domain
precursor_groups_862 89.91 +- 56.10 3 0 1 0 0.10 +- 0.13 3

No common domains found
precursor_groups_27701 9.88 +- 1.70 3 0 0 0 0.21 +- 0.25 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_22780 960.29 +- 332.05 5 0 0 0 0.02 +- 0.01 5 9

PF13649 (5/5) Methyltransferase domain
PF12698 (5/5) ABC-2 family transporter protein
PF02441 (5/5) Flavoprotein
PF00005 (5/5) ABC transporter
PF17914 (4/5) HopA1 effector protein family
PF01636 (4/5) Phosphotransferase enzyme family
PF00664 (4/5) ABC transporter transmembrane region
PF13732 (3/5) Domain of unknown function (DUF4162)
PF00196 (3/5) Bacterial regulatory proteins, luxR family
precursor_groups_41827 1399.34 +- 29.58 2 0 2 2 0.02 +- 0.02 2 7

PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF15567 (2/2) Immunity protein 35
PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (2/2) Peptidase family M20/M25/M40
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
precursor_groups_58071 236.84 +- 33.16 2 0 0 0 0.08 +- 0.09 2 6

PF14534 (2/2) Domain of unknown function (DUF4440)
PF08002 (2/2) Protein of unknown function (DUF1697)
PF05922 (2/2) Peptidase inhibitor I9
PF00664 (2/2) ABC transporter transmembrane region
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
precursor_groups_41825 89.22 +- 38.28 3 0 0 0 0.14 +- 0.16 3 8

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF01613 (3/3) Flavin reductase like domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00480 (3/3) ROK family
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
PF00248 (2/3) Aldo/keto reductase family
precursor_groups_41828 335.62 +- 129.52 2 0 0 2 0.11 +- 0.10 2 9

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
precursor_groups_23281 84.15 +- 89.10 5 0 4 0 0.06 +- 0.07 5 2

PF01510 (5/5) N-acetylmuramoyl-L-alanine amidase
PF01183 (5/5) Glycosyl hydrolases family 25
precursor_groups_56385 128.60 +- 0.40 2 0 0 0 0.16 +- 0.33 2 15

PF13473 (2/2) Cupredoxin-like domain
PF13462 (2/2) Thioredoxin
PF13386 (2/2) Cytochrome C biogenesis protein transmembrane region
PF11303 (2/2) Protein of unknown function (DUF3105)
PF11292 (2/2) Protein of unknown function (DUF3093)
PF09678 (2/2) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF09490 (2/2) Probable cobalt transporter subunit (CbtA)
PF09489 (2/2) Probable cobalt transporter subunit (CbtB)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF00484 (2/2) Carbonic anhydrase
PF00403 (2/2) Heavy-metal-associated domain
precursor_groups_3304 1684.33 +- 867.88 25 0 25 25 0.04 +- 0.06 25 11

TIGR01208 (25/25) glucose-1-phosphate thymidylyltransferase
PF13649 (25/25) Methyltransferase domain
PF05147 (25/25) Lanthionine synthetase C-like protein
PF00535 (25/25) Glycosyl transferase family 2
PF00483 (25/25) Nucleotidyl transferase
PF00465 (25/25) Iron-containing alcohol dehydrogenase
PF00296 (25/25) Luciferase-like monooxygenase
PF00202 (25/25) Aminotransferase class-III
PF00132 (25/25) Bacterial transferase hexapeptide (six repeats)
PF00069 (25/25) Protein kinase domain
PF00005 (25/25) ABC transporter
precursor_groups_82658 82.79 +- 2.04 2 0 2 0 0.08 +- 0.02 2 13

PF17645 (2/2) Arylmalonate decarboxylase
PF12697 (2/2) Alpha/beta hydrolase family
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01494 (2/2) FAD binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (2/2) MarR family
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00857 (2/2) Isochorismatase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_22971 305.85 +- 81.15 2 0 0 0 0.03 +- 0.02 2 9

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF12724 (2/2) Flavodoxin domain
PF12679 (2/2) ABC-2 family transporter protein
PF08962 (2/2) Domain of unknown function (DUF1876)
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00690 (2/2) Cation transporter/ATPase, N-terminus
PF00689 (2/2) Cation transporting ATPase, C-terminus
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_groups_7149 77.22 +- 52.18 5 0 0 0 0.08 +- 0.03 5 10

PF17801 (5/5) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (5/5) Alpha galactosidase A
PF07995 (5/5) Glucose / Sorbosone dehydrogenase
PF07470 (5/5) Glycosyl Hydrolase Family 88
PF03422 (5/5) Carbohydrate binding module (family 6)
PF01120 (5/5) Alpha-L-fucosidase
PF00754 (5/5) F5/8 type C domain
PF14099 (4/5) Polysaccharide lyase
PF00704 (4/5) Glycosyl hydrolases family 18
PF00041 (4/5) Fibronectin type III domain
precursor_groups_22977 3093.32 +- 1059.07 5 0 5 5 0.01 +- 0.02 5 8

PF13649 (5/5) Methyltransferase domain
PF12730 (5/5) ABC-2 family transporter protein
PF05147 (5/5) Lanthionine synthetase C-like protein
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00296 (5/5) Luciferase-like monooxygenase
PF00202 (5/5) Aminotransferase class-III
PF00069 (5/5) Protein kinase domain
PF00005 (5/5) ABC transporter
precursor_groups_40190 137.66 +- 36.57 3 0 2 0 0.10 +- 0.27 3 14

TIGR00223 (3/3) aspartate 1-decarboxylase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02261 (3/3) Aspartate decarboxylase
PF01613 (3/3) Flavin reductase like domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00107 (3/3) Zinc-binding dehydrogenase
PF00561 (2/3) alpha/beta hydrolase fold
precursor_groups_26474 363.20 +- 37.90 3 0 0 3 0.01 +- 0.00 3 5

TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF13537 (3/3) Glutamine amidotransferase domain
PF01474 (3/3) Class-II DAHP synthetase family
PF00733 (3/3) Asparagine synthase
PF00221 (3/3) Aromatic amino acid lyase
precursor_groups_11811 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_groups_16286 366.86 +- 225.21 5 0 5 5 0.06 +- 0.09 5 5

PF13302 (5/5) Acetyltransferase (GNAT) domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF00069 (5/5) Protein kinase domain
PF00294 (4/5) pfkB family carbohydrate kinase
PF02653 (3/5) Branched-chain amino acid transport system / permease component
precursor_groups_68952 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_groups_7069 331.15 +- 170.70 3 0 0 0 0.05 +- 0.06 3 3

PF08007 (3/3) Cupin superfamily protein
PF00248 (3/3) Aldo/keto reductase family
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_53738 2291.55 +- 1062.45 2 0 0 0 0.01 +- 0.01 2 14

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF12146 (2/2) Serine aminopeptidase, S33
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (2/2) GH3 auxin-responsive promoter
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)
precursor_groups_8675 24.49 +- 4.96 4 0 0 0 0.08 +- 0.06 4 2

PF08445 (4/4) FR47-like protein
PF01810 (4/4) LysE type translocator
precursor_groups_23575 213.71 +- 68.52 5 0 5 0 0.02 +- 0.01 5 4

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF04673 (5/5) Polyketide synthesis cyclase
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF00067 (5/5) Cytochrome P450
precursor_groups_34622 441.25 +- 288.15 3 0 0 0 0.09 +- 0.20 3 11

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13490 (3/3) Putative zinc-finger
PF12697 (3/3) Alpha/beta hydrolase family
PF10099 (3/3) Anti-sigma-K factor rskA
PF08281 (3/3) Sigma-70, region 4
PF07103 (3/3) Protein of unknown function (DUF1365)
PF06966 (3/3) Protein of unknown function (DUF1295)
PF04542 (3/3) Sigma-70 region 2
PF02353 (3/3) Mycolic acid cyclopropane synthetase
PF01593 (3/3) Flavin containing amine oxidoreductase
precursor_groups_15261 81.71 +- 21.70 3 0 0 0 0.08 +- 0.19 3 13

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13607 (3/3) Succinyl-CoA ligase like flavodoxin domain
PF13549 (3/3) ATP-grasp domain
PF13459 (3/3) 4Fe-4S single cluster domain
PF13380 (3/3) CoA binding domain
PF10589 (3/3) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (3/3) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_3792 333.38 +- 53.62 2 0 0 0 0.09 +- 0.04 2 9

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
precursor_groups_11727 201.85 +- 66.84 7 0 5 0 0.15 +- 0.21 7 11

TIGR03797 (7/7) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (7/7) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF10604 (7/7) Polyketide cyclase / dehydrase and lipid transport
PF07690 (7/7) Major Facilitator Superfamily
PF03412 (7/7) Peptidase C39 family
PF00664 (7/7) ABC transporter transmembrane region
PF00440 (7/7) Bacterial regulatory proteins, tetR family
PF00005 (7/7) ABC transporter
PF13437 (6/7) HlyD family secretion protein
PF03055 (6/7) Retinal pigment epithelial membrane protein
PF05013 (5/7) N-formylglutamate amidohydrolase
precursor_groups_44522 76.17 +- 27.03 2 0 2 0 0.03 +- 0.03 2 6

PF14525 (2/2) AraC-binding-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12833 (2/2) Helix-turn-helix domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_51525 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_73777 149.12 +- 39.59 2 0 0 0 0.06 +- 0.02 2 7

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_75735 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_8075 271.40 +- 269.29 6 0 0 0 0.10 +- 0.20 6 11

PF00535 (6/6) Glycosyl transferase family 2
PF00082 (6/6) Subtilase family
TIGR01426 (5/6) glycosyltransferase, MGT family
PF00201 (5/6) UDP-glucoronosyl and UDP-glucosyl transferase
PF00089 (4/6) Trypsin
PF13546 (3/6) DDE superfamily endonuclease
PF13385 (3/6) Concanavalin A-like lectin/glucanases superfamily
PF07591 (3/6) Pretoxin HINT domain
PF04471 (3/6) Restriction endonuclease
PF03752 (3/6) Short repeats of unknown function
PF03009 (3/6) Glycerophosphoryl diester phosphodiesterase family
precursor_groups_3798 156.12 +- 90.96 12 0 12 0 0.03 +- 0.04 12 8

PF13649 (12/12) Methyltransferase domain
PF13450 (12/12) NAD(P)-binding Rossmann-like domain
PF12697 (12/12) Alpha/beta hydrolase family
PF07730 (12/12) Histidine kinase
PF00664 (12/12) ABC transporter transmembrane region
PF00005 (12/12) ABC transporter
PF00196 (6/12) Bacterial regulatory proteins, luxR family
PF00072 (6/12) Response regulator receiver domain
precursor_groups_10146 144.48 +- 52.90 5 0 0 0 0.03 +- 0.02 5 9

TIGR00557 (5/5) 4-hydroxythreonine-4-phosphate dehydrogenase PdxA
PF17042 (5/5) Nucleotide-binding C-terminal domain
PF13396 (5/5) Phospholipase_D-nuclease N-terminal
PF09851 (5/5) Short C-terminal domain
PF08220 (5/5) DeoR-like helix-turn-helix domain
PF07690 (5/5) Major Facilitator Superfamily
PF07005 (5/5) Sugar-binding N-terminal domain
PF04166 (5/5) Pyridoxal phosphate biosynthetic protein PdxA
PF00455 (5/5) DeoR C terminal sensor domain
precursor_groups_9782 37.02 +- 9.98 5 0 0 0 0.14 +- 0.26 5 10

PF14542 (5/5) GCN5-related N-acetyl-transferase
PF12802 (5/5) MarR family
PF07690 (5/5) Major Facilitator Superfamily
PF05726 (5/5) Pirin C-terminal cupin domain
PF02678 (5/5) Pirin
PF01326 (5/5) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00089 (5/5) Trypsin
TIGR04036 (4/5) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF14559 (4/5) Tetratricopeptide repeat
PF00296 (4/5) Luciferase-like monooxygenase
precursor_groups_1798 106.33 +- 42.78 4 0 0 0 0.04 +- 0.04 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF00027 (4/4) Cyclic nucleotide-binding domain
PF13581 (2/4) Histidine kinase-like ATPase domain
PF08448 (2/4) PAS fold
PF01590 (2/4) GAF domain
precursor_groups_36665 536.25 +- 243.75 2 0 1 0 0.01 +- 0.01 2 12

PF13377 (2/2) Periplasmic binding protein-like domain
PF00756 (2/2) Putative esterase
PF00501 (2/2) AMP-binding enzyme
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00550 (1/2) Phosphopantetheine attachment site
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_83377 46.80 +- 0.00 2 0 2 0 0.06 +- 0.07 2 5

TIGR00842 (2/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF13309 (2/2) HTH domain
PF08348 (2/2) YheO-like PAS domain
PF02028 (2/2) BCCT, betaine/carnitine/choline family transporter
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_1795 493.74 +- 248.56 36 0 36 36 0.05 +- 0.03 36 9

TIGR03891 (36/36) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (36/36) Lantibiotic biosynthesis dehydratase C-term
PF05147 (36/36) Lanthionine synthetase C-like protein
PF04738 (36/36) Lantibiotic dehydratase, N terminus
PF00392 (36/36) Bacterial regulatory proteins, gntR family
PF00196 (36/36) Bacterial regulatory proteins, luxR family
PF05139 (35/36) Erythromycin esterase
PF00296 (35/36) Luciferase-like monooxygenase
PF00005 (35/36) ABC transporter
precursor_groups_11925 73.66 +- 35.41 5 0 0 0 0.11 +- 0.14 5 4

PF08241 (5/5) Methyltransferase domain
PF00293 (5/5) NUDIX domain
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00005 (5/5) ABC transporter
precursor_groups_23026 215.15 +- 18.71 5 0 0 5 0.03 +- 0.01 5 5

PF13480 (5/5) Acetyltransferase (GNAT) domain
PF08282 (5/5) haloacid dehalogenase-like hydrolase
PF04339 (5/5) Peptidogalycan biosysnthesis/recognition
PF04055 (5/5) Radical SAM superfamily
PF00303 (5/5) Thymidylate synthase
precursor_groups_59709 44.20 +- 4.17 2 0 0 0 0.07 +- 0.06 2 5

PF02945 (2/2) Recombination endonuclease VII
PF00950 (2/2) ABC 3 transport family
PF00891 (2/2) O-methyltransferase domain
PF00351 (2/2) Biopterin-dependent aromatic amino acid hydroxylase
PF00005 (2/2) ABC transporter
precursor_groups_8091 28.46 +- 0.00 2 0 0 0 0.21 +- 0.18 2 5

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02687 (2/2) FtsX-like permease family
PF01152 (2/2) Bacterial-like globin
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
precursor_groups_29708 86.99 +- 43.01 2 0 0 0 0.05 +- 0.08 2 5

PF14078 (2/2) Domain of unknown function (DUF4259)
PF13649 (2/2) Methyltransferase domain
PF03780 (2/2) Asp23 family, cell envelope-related function
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF06902 (1/2) Divergent 4Fe-4S mono-cluster
precursor_groups_20007 153.33 +- 63.33 2 0 0 0 0.04 +- 0.03 2 11

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00775 (2/2) Dioxygenase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_8099 329.74 +- 323.40 9 0 9 0 0.11 +- 0.27 9 10

TIGR03025 (9/9) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (9/9) Glycosyl transferases group 1
PF13480 (9/9) Acetyltransferase (GNAT) domain
PF13439 (9/9) Glycosyltransferase Family 4
PF04932 (9/9) O-Antigen ligase
PF03777 (9/9) ChpA-C
PF03023 (9/9) Lipid II flippase MurJ
PF02397 (9/9) Bacterial sugar transferase
PF01522 (9/9) Polysaccharide deacetylase
PF00534 (9/9) Glycosyl transferases group 1
precursor_groups_27052 69.21 +- 27.54 2 0 0 0 0.07 +- 0.07 2 3

PF13489 (2/2) Methyltransferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_28088 19.54 +- 2.52 4 0 0 0 0.19 +- 0.29 4 8

TIGR02980 (4/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14087 (4/4) Domain of unknown function (DUF4267)
PF13649 (4/4) Methyltransferase domain
PF04545 (4/4) Sigma-70, region 4
PF04542 (4/4) Sigma-70 region 2
PF04539 (4/4) Sigma-70 region 3
PF01590 (4/4) GAF domain
PF00583 (3/4) Acetyltransferase (GNAT) family
precursor_groups_10529 55.73 +- 16.93 8 0 0 0 0.14 +- 0.18 8 7

TIGR00996 (8/8) virulence factor Mce family protein
PF13406 (8/8) Transglycosylase SLT domain
PF11887 (8/8) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (8/8) MlaD protein
PF02405 (8/8) Permease MlaE
PF00005 (8/8) ABC transporter
PF13577 (5/8) SnoaL-like domain
precursor_groups_12642 194.17 +- 42.63 5 0 3 0 0.01 +- 0.00 5 5

TIGR02276 (5/5) 40-residue YVTN family beta-propeller repeat
PF16640 (5/5) Bacterial Ig-like domain (group 3)
PF14378 (5/5) PAP2 superfamily
PF09594 (5/5) Glycosyltransferase family 87
PF01833 (5/5) IPT/TIG domain
precursor_groups_51638 193.28 +- 26.44 2 0 0 0 0.11 +- 0.08 2 5

PF05426 (2/2) Alginate lyase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00295 (2/2) Glycosyl hydrolases family 28
PF00135 (1/2) Carboxylesterase family
precursor_groups_16085 130.43 +- 37.89 4 0 0 0 0.18 +- 0.31 4 9

TIGR03177 (4/4) Flp pilus assembly protein CpaB
PF16976 (4/4) Flp pilus assembly protein RcpC/CpaB
PF13400 (4/4) Putative Flp pilus-assembly TadE/G-like
PF08666 (4/4) SAF domain
PF07811 (4/4) TadE-like protein
PF00691 (4/4) OmpA family
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF13614 (3/4) AAA domain
precursor_groups_37596 26.09 +- 2.18 2 0 0 0 0.15 +- 0.26 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00135 (2/2) Carboxylesterase family
precursor_groups_48189 114.99 +- 57.07 2 0 0 0 0.13 +- 0.07 2 5

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF02254 (2/2) TrkA-N domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_groups_6183 529.41 +- 70.59 2 0 2 2 0.01 +- 0.01 2 8

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05368 (2/2) NmrA-like family
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03995 (2/2) Peptidase inhibitor family I36
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_10527 26.83 +- 5.46 6 0 0 0 0.08 +- 0.04 6 2

PF02734 (6/6) DAK2 domain
PF02733 (6/6) Dak1 domain
precursor_groups_15006 77.49 +- 30.09 7 0 0 0 0.12 +- 0.16 7 7

TIGR00996 (7/7) virulence factor Mce family protein
PF11887 (7/7) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (7/7) MlaD protein
PF02405 (7/7) Permease MlaE
PF00005 (7/7) ABC transporter
PF13406 (6/7) Transglycosylase SLT domain
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
precursor_groups_22134 345.07 +- 214.66 5 0 5 0 0.02 +- 0.01 5 15

TIGR01733 (5/5) amino acid adenylation domain
TIGR01188 (5/5) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00838 (5/5) argininosuccinate lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF11495 (5/5) Archaeal transcriptional regulator TrmB
PF03767 (5/5) HAD superfamily, subfamily IIIB (Acid phosphatase)
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_groups_9417 214.98 +- 91.02 10 0 0 0 0.02 +- 0.01 10 6

TIGR03930 (10/10) WXG100 family type VII secretion target
TIGR03921 (10/10) type VII secretion-associated serine protease mycosin
TIGR03919 (10/10) type VII secretion protein EccB
PF06013 (10/10) Proteins of 100 residues with WXG
PF05108 (10/10) Type VII secretion system ESX-1, transport TM domain B
PF00082 (10/10) Subtilase family
precursor_groups_9415 9.58 +- 1.75 4 0 0 0 0.21 +- 0.06 4 5

PF07676 (4/4) WD40-like Beta Propeller Repeat
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01979 (4/4) Amidohydrolase family
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_77079 317.93 +- 51.48 2 0 0 0 0.05 +- 0.07 2 7

PF13649 (2/2) Methyltransferase domain
PF08242 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01411 (2/2) tRNA synthetases class II (A)
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_70727 111.52 +- 3.19 2 0 0 0 0.03 +- 0.03 2 4

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF02566 (2/2) OsmC-like protein
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_53901 497.18 +- 7.60 2 0 0 0 0.06 +- 0.15 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF13473 (2/2) Cupredoxin-like domain
PF12698 (2/2) ABC-2 family transporter protein
PF11666 (2/2) Protein of unknown function (DUF2933)
PF07690 (2/2) Major Facilitator Superfamily
PF04945 (2/2) YHS domain
PF04191 (2/2) Phospholipid methyltransferase
PF04012 (2/2) PspA/IM30 family
PF03713 (2/2) Domain of unknown function (DUF305)
PF01435 (2/2) Peptidase family M48
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_groups_1546 148.78 +- 104.60 7 0 6 0 0.03 +- 0.02 7 3

PF09924 (7/7) Uncharacterised conserved protein (DUF2156)
PF07690 (7/7) Major Facilitator Superfamily
PF00487 (7/7) Fatty acid desaturase
precursor_groups_23621 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
precursor_groups_5168 114.27 +- 17.27 3 0 3 0 0.06 +- 0.13 3 8

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
TIGR01534 (2/3) glyceraldehyde-3-phosphate dehydrogenase, type I
PF13450 (2/3) NAD(P)-binding Rossmann-like domain
PF02800 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_13055 119.89 +- 53.23 3 0 0 0 0.02 +- 0.01 3 5

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_52985 91.60 +- 0.33 2 0 2 0 0.10 +- 0.29 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_52984 944.76 +- 201.90 2 0 0 0 0.01 +- 0.01 2 14

PF18565 (2/2) Glycoside hydrolase family 2 C-terminal domain 5
PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF14310 (2/2) Fibronectin type III-like domain
PF13546 (2/2) DDE superfamily endonuclease
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_66228 256.29 +- 219.14 2 0 0 0 0.07 +- 0.13 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_8327 96.64 +- 82.42 7 0 0 0 0.06 +- 0.08 7 3

PF02515 (7/7) CoA-transferase family III
PF00082 (7/7) Subtilase family
PF05425 (4/7) Copper resistance protein D
precursor_groups_18543 200.98 +- 25.48 2 0 0 0 0.06 +- 0.03 2 8

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF03466 (2/2) LysR substrate binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00722 (2/2) Glycosyl hydrolases family 16
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_50588 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_40537 86.26 +- 17.46 2 0 0 0 0.19 +- 0.11 2 5

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_23915 21.98 +- 5.92 3 0 0 0 0.10 +- 0.06 3 5

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_65929 76.18 +- 52.82 2 0 2 0 0.13 +- 0.25 2 9

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03567 (2/2) FMN reductase
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF03358 (2/2) NADPH-dependent FMN reductase
PF01494 (2/2) FAD binding domain
PF00483 (2/2) Nucleotidyl transferase
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_45012 286.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF05729 (1/2) NACHT domain
precursor_groups_67019 967.50 +- 193.50 2 0 0 0 0.01 +- 0.00 2 7

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06259 (2/2) Alpha/beta hydrolase
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
TIGR03930 (1/2) WXG100 family type VII secretion target
PF06013 (1/2) Proteins of 100 residues with WXG
precursor_groups_50921 50.89 +- 7.89 2 0 2 0 0.09 +- 0.13 2 7

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF18844 (2/2) Bacterial archaeo-eukaryotic release factor family 2
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00384 (2/2) Molybdopterin oxidoreductase
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10990 (1/2) Protein of unknown function (DUF2809)
PF00795 (1/2) Carbon-nitrogen hydrolase
precursor_groups_40334 1659.14 +- 53.80 2 0 2 0 0.01 +- 0.01 2 10

PF13622 (2/2) Thioesterase-like superfamily
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00301 (2/2) Rubredoxin
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
precursor_groups_8527 112.82 +- 35.81 3 0 0 0 0.06 +- 0.09 3 5

TIGR01979 (3/3) cysteine desulfurase, SufS family
PF03466 (3/3) LysR substrate binding domain
PF00266 (3/3) Aminotransferase class-V
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00027 (3/3) Cyclic nucleotide-binding domain
precursor_groups_8521 123.62 +- 97.58 3 0 0 0 0.03 +- 0.03 3 3

PF07702 (3/3) UTRA domain
PF00668 (3/3) Condensation domain
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_15130 106.88 +- 99.20 6 0 6 0 0.06 +- 0.06 6 5

PF07690 (6/6) Major Facilitator Superfamily
PF05893 (6/6) Acyl-CoA reductase (LuxC)
PF04443 (6/6) Acyl-protein synthetase, LuxE
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00501 (6/6) AMP-binding enzyme
precursor_groups_21535 217.74 +- 45.15 4 0 3 4 0.01 +- 0.00 4 4

TIGR01444 (4/4) methyltransferase, FkbM family
PF05050 (4/4) Methyltransferase FkbM domain
PF04055 (4/4) Radical SAM superfamily
PF02310 (4/4) B12 binding domain
precursor_groups_27294 145.93 +- 80.58 4 0 0 0 0.05 +- 0.04 4 12

TIGR01167 (4/4) LPXTG cell wall anchor domain
PF18130 (4/4) ATP-grasp N-terminal domain
PF17802 (4/4) Prealbumin-like fold domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF04828 (4/4) Glutathione-dependent formaldehyde-activating enzyme
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF00583 (4/4) Acetyltransferase (GNAT) family
PF01555 (3/4) DNA methylase
precursor_groups_20824 734.63 +- 744.78 5 0 5 0 0.07 +- 0.13 5 25

PF03929 (5/5) PepSY-associated TM region
TIGR01525 (4/5) heavy metal translocating P-type ATPase
PF04314 (4/5) Copper chaperone PCu(A)C
PF01965 (4/5) DJ-1/PfpI family
PF01794 (4/5) Ferric reductase like transmembrane component
PF00702 (4/5) haloacid dehalogenase-like hydrolase
PF00403 (4/5) Heavy-metal-associated domain
PF00122 (4/5) E1-E2 ATPase
TIGR01746 (3/5) thioester reductase domain
TIGR01733 (3/5) amino acid adenylation domain
TIGR00747 (3/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/5) AMP-binding enzyme C-terminal domain
PF10862 (3/5) FcoT-like thioesterase domain
PF08545 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (3/5) Male sterility protein
PF07690 (3/5) Major Facilitator Superfamily
PF05118 (3/5) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/5) Periplasmic binding protein
PF01032 (3/5) FecCD transport family
PF00668 (3/5) Condensation domain
PF00550 (3/5) Phosphopantetheine attachment site
PF00501 (3/5) AMP-binding enzyme
PF00005 (3/5) ABC transporter
precursor_groups_10459 98.12 +- 43.92 8 0 8 0 0.11 +- 0.18 8 20

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (8/8) amino acid adenylation domain
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF03067 (8/8) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF02127 (8/8) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (8/8) Thioesterase domain
PF00877 (8/8) NlpC/P60 family
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00296 (8/8) Luciferase-like monooxygenase
PF00202 (8/8) Aminotransferase class-III
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF01145 (6/8) SPFH domain / Band 7 family
PF12158 (5/8) Protein of unknown function (DUF3592)
precursor_groups_8528 22.76 +- 0.00 2 0 0 0 0.09 +- 0.10 2 6

TIGR02608 (2/2) delta-60 repeat domain
TIGR01451 (2/2) conserved repeat domain
PF17164 (2/2) Domain of unknown function (DUF5122) beta-propeller
PF02811 (2/2) PHP domain
PF01345 (2/2) Domain of unknown function DUF11
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_groups_37828 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_groups_333 190.48 +- 77.47 3 0 1 0 0.05 +- 0.04 3 1

PF07690 (2/3) Major Facilitator Superfamily
precursor_groups_335 36.36 +- 51.72 96 0 11 0 0.17 +- 0.11 96 3

PF00355 (95/96) Rieske [2Fe-2S] domain
PF00111 (95/96) 2Fe-2S iron-sulfur cluster binding domain
PF00175 (88/96) Oxidoreductase NAD-binding domain
precursor_groups_5898 158.95 +- 206.43 8 0 5 0 0.07 +- 0.11 8 6

PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (8/8) BFD-like [2Fe-2S] binding domain
PF02782 (8/8) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (8/8) FAD dependent oxidoreductase
PF00370 (8/8) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (5/8) NUDIX domain
precursor_groups_14285 296.32 +- 198.22 5 0 1 0 0.05 +- 0.05 5 10

PF16259 (5/5) Domain of unknown function (DUF4913)
PF07690 (5/5) Major Facilitator Superfamily
PF03771 (5/5) Domain of unknown function (DUF317)
PF01638 (5/5) HxlR-like helix-turn-helix
TIGR01167 (4/5) LPXTG cell wall anchor domain
PF17802 (4/5) Prealbumin-like fold domain
PF13535 (4/5) ATP-grasp domain
PF08239 (4/5) Bacterial SH3 domain
PF01555 (4/5) DNA methylase
PF00583 (4/5) Acetyltransferase (GNAT) family
precursor_groups_32575 115.44 +- 5.97 2 0 0 0 0.03 +- 0.04 2 5

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_39375 308.00 +- 111.72 3 0 3 0 0.01 +- 0.01 3 3

PF05401 (3/3) Nodulation protein S (NodS)
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_71637 595.22 +- 87.28 2 0 0 0 0.03 +- 0.03 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_39995 327.62 +- 23.17 3 0 0 0 0.01 +- 0.01 3 6

PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF03466 (3/3) LysR substrate binding domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00884 (3/3) Sulfatase
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_72164 263.12 +- 19.07 2 0 0 0 0.05 +- 0.06 2 11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF13237 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01061 (2/2) ABC-2 type transporter
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_4785 116.98 +- 50.55 3 0 0 0 0.04 +- 0.05 3 3

PF07702 (3/3) UTRA domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_58690 387.50 +- 257.50 2 0 2 0 0.02 +- 0.01 2 5

PF13523 (2/2) Acetyltransferase (GNAT) domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF04183 (2/2) IucA / IucC family
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
precursor_groups_60599 413.29 +- 144.17 2 0 2 0 0.06 +- 0.18 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02153 (2/2) Prephenate dehydrogenase
PF01070 (2/2) FMN-dependent dehydrogenase
PF00672 (2/2) HAMP domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
precursor_groups_10856 107.82 +- 38.90 5 0 5 0 0.18 +- 0.14 5 12

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13672 (5/5) Protein phosphatase 2C
PF13411 (5/5) MerR HTH family regulatory protein
PF09335 (5/5) SNARE associated Golgi protein
PF07944 (5/5) Beta-L-arabinofuranosidase, GH127
PF07730 (5/5) Histidine kinase
PF05448 (5/5) Acetyl xylan esterase (AXE1)
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
PF00005 (5/5) ABC transporter
precursor_groups_16462 72.37 +- 12.06 2 0 0 0 0.06 +- 0.01 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13535 (2/2) ATP-grasp domain
PF13394 (2/2) 4Fe-4S single cluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00355 (2/2) Rieske [2Fe-2S] domain
precursor_groups_46472 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
precursor_groups_2839 47.56 +- 24.22 16 0 0 0 0.10 +- 0.10 16 4

TIGR03860 (16/16) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (16/16) Major Facilitator Superfamily
PF00296 (16/16) Luciferase-like monooxygenase
PF00106 (14/16) short chain dehydrogenase
precursor_groups_41316 308.86 +- 188.86 3 0 3 0 0.12 +- 0.27 3 19

PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02153 (3/3) Prephenate dehydrogenase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00672 (3/3) HAMP domain
PF00664 (3/3) ABC transporter transmembrane region
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
TIGR01733 (2/3) amino acid adenylation domain
TIGR01720 (2/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF00668 (2/3) Condensation domain
PF00561 (2/3) alpha/beta hydrolase fold
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
precursor_groups_36081 305.62 +- 233.24 3 0 3 0 0.03 +- 0.04 3 9

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF08659 (3/3) KR domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_2836 335.00 +- 185.00 2 0 0 0 0.02 +- 0.01 2 12

TIGR02089 (1/2) tartrate dehydrogenase
PF14330 (1/2) Domain of unknown function (DUF4387)
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF07690 (1/2) Major Facilitator Superfamily
PF07287 (1/2) Acyclic terpene utilisation family protein AtuA
PF03358 (1/2) NADPH-dependent FMN reductase
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01321 (1/2) Creatinase/Prolidase N-terminal domain
PF00557 (1/2) Metallopeptidase family M24
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
precursor_groups_69087 85.66 +- 58.78 2 0 0 0 0.07 +- 0.17 2 6

PF13545 (2/2) Crp-like helix-turn-helix domain
PF11575 (2/2) FhuF 2Fe-2S C-terminal domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00005 (2/2) ABC transporter
precursor_groups_84500 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF16864 (2/2) Dimerisation domain
PF00891 (2/2) O-methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_46053 95.94 +- 24.92 3 0 0 0 0.03 +- 0.02 3 4

PF13649 (3/3) Methyltransferase domain
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
precursor_groups_82367 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_50079 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF07538 (2/2) Clostridial hydrophobic W
PF07179 (2/2) SseB protein N-terminal domain
PF04198 (2/2) Putative sugar-binding domain
PF03692 (2/2) Putative zinc- or iron-chelating domain
precursor_groups_5764 172.74 +- 127.94 3 0 1 0 0.04 +- 0.09 3 11

TIGR00557 (2/3) 4-hydroxythreonine-4-phosphate dehydrogenase PdxA
PF17203 (2/3) Single cache domain 3
PF17042 (2/3) Nucleotide-binding C-terminal domain
PF13581 (2/3) Histidine kinase-like ATPase domain
PF13185 (2/3) GAF domain
PF08220 (2/3) DeoR-like helix-turn-helix domain
PF07690 (2/3) Major Facilitator Superfamily
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF07005 (2/3) Sugar-binding N-terminal domain
PF04166 (2/3) Pyridoxal phosphate biosynthetic protein PdxA
PF00455 (2/3) DeoR C terminal sensor domain
precursor_groups_21286 78.20 +- 29.31 4 0 4 0 0.19 +- 0.20 4 20

TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00566 (4/4) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (4/4) aminodeoxychorismate synthase, component I
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF04715 (4/4) Anthranilate synthase component I, N terminal region
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01061 (4/4) ABC-2 type transporter
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00425 (4/4) chorismate binding enzyme
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_groups_48382 644.06 +- 387.94 2 0 2 0 0.04 +- 0.14 2 26

TIGR03081 (2/2) methylmalonyl-CoA epimerase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01194 (2/2) cyclic peptide transporter
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (2/2) ParB-like nuclease domain
PF01804 (2/2) Penicillin amidase
PF01066 (2/2) CDP-alcohol phosphatidyltransferase
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_63001 105.74 +- 24.26 2 0 0 0 0.03 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_5098 22.97 +- 9.28 2 0 0 0 0.12 +- 0.08 2 9

PF17868 (1/2) AAA lid domain
PF09957 (1/2) Bacterial antitoxin of type II TA system, VapB
PF08534 (1/2) Redoxin
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF01850 (1/2) PIN domain
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00376 (1/2) MerR family regulatory protein
PF00171 (1/2) Aldehyde dehydrogenase family
PF00106 (1/2) short chain dehydrogenase
precursor_groups_59507 60.28 +- 4.67 2 0 0 0 0.13 +- 0.30 2 4

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03780 (2/2) Asp23 family, cell envelope-related function
precursor_groups_77287 476.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 3

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_28035 133.74 +- 6.33 3 0 0 0 0.13 +- 0.29 3 12

PF16925 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14534 (3/3) Domain of unknown function (DUF4440)
PF13602 (3/3) Zinc-binding dehydrogenase
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13160 (3/3) Protein of unknown function (DUF3995)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF05195 (3/3) Aminopeptidase P, N-terminal domain
PF04951 (3/3) D-aminopeptidase
PF00557 (3/3) Metallopeptidase family M24
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_66314 262.96 +- 124.04 2 0 2 0 0.04 +- 0.07 2 14

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF12680 (2/2) SnoaL-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF00975 (1/2) Thioesterase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_13393 41.95 +- 36.10 5 0 0 0 0.11 +- 0.13 5 2

PF13649 (5/5) Methyltransferase domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_47870 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_groups_5234 140.33 +- 77.44 4 0 0 0 0.02 +- 0.02 4 3

PF14099 (4/4) Polysaccharide lyase
PF01120 (4/4) Alpha-L-fucosidase
PF00754 (4/4) F5/8 type C domain
precursor_groups_35696 158.77 +- 13.23 2 0 0 0 0.08 +- 0.05 2 7

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_76005 69.12 +- 27.63 2 0 0 0 0.05 +- 0.07 2 9

TIGR02115 (2/2) K+-transporting ATPase, F subunit
PF13493 (2/2) Domain of unknown function (DUF4118)
PF12746 (2/2) GNAT acetyltransferase
PF09604 (2/2) F subunit of K+-transporting ATPase (Potass_KdpF)
PF02702 (2/2) Osmosensitive K+ channel His kinase sensor domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00582 (2/2) Universal stress protein family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_2232 99.92 +- 60.75 3 0 1 1 0.09 +- 0.15 3

No common domains found
precursor_groups_39195 475.33 +- 60.36 3 0 0 3 0.01 +- 0.00 3 7

TIGR04267 (3/3) HEXXH motif domain
PF07690 (3/3) Major Facilitator Superfamily
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01523 (3/3) Putative modulator of DNA gyrase
PF00899 (3/3) ThiF family
TIGR03891 (2/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/3) Lantibiotic biosynthesis dehydratase C-term
precursor_groups_73941 42.67 +- 14.67 2 0 0 0 0.11 +- 0.18 2 5

PF16670 (2/2) Phosphoinositide phospholipase C, Ca2+-dependent
PF13751 (2/2) Transposase DDE domain
PF13655 (2/2) N-terminal domain of reverse transcriptase
PF03795 (2/2) YCII-related domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_groups_15863 367.65 +- 174.15 2 0 0 0 0.02 +- 0.02 2 10

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07366 (2/2) SnoaL-like polyketide cyclase
PF04978 (2/2) Protein of unknown function (DUF664)
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF12146 (1/2) Serine aminopeptidase, S33
precursor_groups_13370 365.50 +- 21.50 2 0 0 0 0.06 +- 0.09 2 15

PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF03422 (1/2) Carbohydrate binding module (family 6)
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_groups_36889 1326.22 +- 281.32 2 0 0 0 0.01 +- 0.01 2 15

TIGR02960 (2/2) RNA polymerase sigma-70 factor, TIGR02960 family
PF14330 (2/2) Domain of unknown function (DUF4387)
PF08281 (2/2) Sigma-70, region 4
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF07287 (2/2) Acyclic terpene utilisation family protein AtuA
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01872 (2/2) RibD C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_32561 46.49 +- 20.71 3 0 0 0 0.08 +- 0.08 3 5

PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09335 (3/3) SNARE associated Golgi protein
PF07532 (3/3) Bacterial Ig-like domain (group 4)
PF04616 (3/3) Glycosyl hydrolases family 43
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_39200 624.08 +- 220.36 2 0 1 0 0.05 +- 0.11 2 29

PF17677 (2/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF12840 (2/2) Helix-turn-helix domain
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (2/2) Alpha mannosidase middle domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (2/2) Trehalose utilisation
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01686 (1/2) FkbH domain
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00067 (1/2) Cytochrome P450
precursor_groups_2781 11.37 +- 2.70 2 0 0 0 0.19 +- 0.32 2 11

PF13649 (2/2) Methyltransferase domain
TIGR01389 (1/2) ATP-dependent DNA helicase RecQ
PF16124 (1/2) RecQ zinc-binding
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13426 (1/2) PAS domain
PF09382 (1/2) RQC domain
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00570 (1/2) HRDC domain
PF00271 (1/2) Helicase conserved C-terminal domain
PF00270 (1/2) DEAD/DEAH box helicase
precursor_groups_19730 23.27 +- 3.11 3 0 0 0 0.09 +- 0.08 3 3

PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00457 (3/3) Glycosyl hydrolases family 11
PF00331 (3/3) Glycosyl hydrolase family 10
precursor_groups_15869 16.83 +- 0.00 2 0 2 0 0.18 +- 0.22 2 5

TIGR00738 (2/2) Rrf2 family protein
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF05532 (2/2) CsbD-like
PF02082 (2/2) Transcriptional regulator
PF01979 (2/2) Amidohydrolase family
precursor_groups_32566 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_74864 354.97 +- 8.87 2 0 0 0 0.03 +- 0.01 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_76733 780.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF12802 (2/2) MarR family
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
precursor_groups_19934 760.91 +- 1297.46 5 0 0 0 0.02 +- 0.02 5 5

PF01494 (5/5) FAD binding domain
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF09339 (4/5) IclR helix-turn-helix domain
PF01614 (4/5) Bacterial transcriptional regulator
PF01557 (4/5) Fumarylacetoacetate (FAA) hydrolase family
precursor_groups_43171 84.43 +- 51.74 3 0 3 0 0.07 +- 0.11 3 8

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13521 (3/3) AAA domain
PF12680 (3/3) SnoaL-like domain
PF11468 (3/3) Aromatic prenyltransferase Orf2
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05655 (3/3) Pseudomonas avirulence D protein (AvrD)
PF03358 (3/3) NADPH-dependent FMN reductase
precursor_groups_243 195.21 +- 102.92 11 0 1 0 0.13 +- 0.29 11 12

PF02446 (11/11) 4-alpha-glucanotransferase
PF01120 (10/11) Alpha-L-fucosidase
TIGR01727 (9/11) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13385 (9/11) Concanavalin A-like lectin/glucanases superfamily
PF13088 (9/11) BNR repeat-like domain
PF12911 (9/11) N-terminal TM domain of oligopeptide transport permease C
PF08352 (9/11) Oligopeptide/dipeptide transporter, C-terminal region
PF00884 (9/11) Sulfatase
PF00701 (9/11) Dihydrodipicolinate synthetase family
PF00528 (9/11) Binding-protein-dependent transport system inner membrane component
PF00496 (9/11) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (9/11) ABC transporter
precursor_groups_241 91.09 +- 98.26 4 0 0 4 0.08 +- 0.12 4 12

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
TIGR04268 (3/4) FXSXX-COOH protein
PF02522 (3/4) Aminoglycoside 3-N-acetyltransferase
PF00931 (3/4) NB-ARC domain
PF13614 (2/4) AAA domain
PF13374 (2/4) Tetratricopeptide repeat
PF01656 (2/4) CobQ/CobB/MinD/ParA nucleotide binding domain
precursor_groups_58383 199.98 +- 2.74 2 0 0 0 0.06 +- 0.09 2 11

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF13377 (2/2) Periplasmic binding protein-like domain
PF13205 (2/2) Bacterial Ig-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_36319 72.62 +- 9.82 2 0 1 0 0.18 +- 0.09 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF07690 (2/2) Major Facilitator Superfamily
PF04016 (2/2) Putative heavy-metal chelation
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
precursor_groups_80744 695.43 +- 594.57 2 0 1 0 0.05 +- 0.13 2 14

PF07690 (2/2) Major Facilitator Superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR01379 (1/2) thiamine-phosphate kinase
PF13520 (1/2) Amino acid permease
PF12704 (1/2) MacB-like periplasmic core domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF02687 (1/2) FtsX-like permease family
PF02224 (1/2) Cytidylate kinase
PF01471 (1/2) Putative peptidoglycan binding domain
PF01435 (1/2) Peptidase family M48
PF01230 (1/2) HIT domain
PF00704 (1/2) Glycosyl hydrolases family 18
PF00586 (1/2) AIR synthase related protein, N-terminal domain
precursor_groups_77457 48.55 +- 5.83 2 0 0 0 0.06 +- 0.06 2 11

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
precursor_groups_5782 38.01 +- 2.35 2 0 0 0 0.21 +- 0.23 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF01427 (2/2) D-ala-D-ala dipeptidase
precursor_groups_57299 2038.78 +- 843.83 2 0 2 0 0.01 +- 0.01 2 23

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF13826 (1/2) Domain of unknown function (DUF4188)
PF13622 (1/2) Thioesterase-like superfamily
PF13279 (1/2) Thioesterase-like superfamily
PF12697 (1/2) Alpha/beta hydrolase family
PF12146 (1/2) Serine aminopeptidase, S33
PF07508 (1/2) Recombinase
PF00668 (1/2) Condensation domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_24657 54.61 +- 10.39 2 0 2 0 0.04 +- 0.06 2 10

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF13354 (2/2) Beta-lactamase enzyme family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF03621 (2/2) MbtH-like protein
PF03588 (2/2) Leucyl/phenylalanyl-tRNA protein transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_2306 248.89 +- 81.63 3 0 1 0 0.05 +- 0.04 3 15

TIGR01727 (2/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13581 (2/3) Histidine kinase-like ATPase domain
PF13377 (2/3) Periplasmic binding protein-like domain
PF12911 (2/3) N-terminal TM domain of oligopeptide transport permease C
PF08448 (2/3) PAS fold
PF08352 (2/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08244 (2/3) Glycosyl hydrolases family 32 C terminal
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF01590 (2/3) GAF domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00496 (2/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/3) Bacterial regulatory proteins, lacI family
PF00251 (2/3) Glycosyl hydrolases family 32 N-terminal domain
PF00248 (2/3) Aldo/keto reductase family
PF00005 (2/3) ABC transporter
precursor_groups_62837 75.00 +- 3.00 2 0 0 0 0.08 +- 0.15 2 4

PF13520 (2/2) Amino acid permease
PF01636 (2/2) Phosphotransferase enzyme family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_groups_27291 142.15 +- 116.47 4 0 0 0 0.07 +- 0.13 4 7

PF16353 (4/4) Domain of unknown function(DUF4981)
PF13385 (4/4) Concanavalin A-like lectin/glucanases superfamily
PF09995 (4/4) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/4) Glycosyl hydrolases family 2
precursor_groups_68877 182.28 +- 67.22 2 0 0 0 0.09 +- 0.06 2 10

TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF16347 (2/2) Domain of unknown function (DUF4976)
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF09084 (2/2) NMT1/THI5 like
PF04909 (2/2) Amidohydrolase
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00005 (2/2) ABC transporter
precursor_groups_801 114.90 +- 117.58 6 0 1 0 0.14 +- 0.20 6 2

PF00553 (6/6) Cellulose binding domain
PF00150 (3/6) Cellulase (glycosyl hydrolase family 5)
precursor_groups_75287 971.25 +- 3.75 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_10458 204.09 +- 95.16 6 0 2 0 0.06 +- 0.02 6 10

PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00378 (6/6) Enoyl-CoA hydratase/isomerase
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00005 (6/6) ABC transporter
PF13561 (5/6) Enoyl-(Acyl carrier protein) reductase
PF08545 (5/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01144 (5/6) Coenzyme A transferase
PF00106 (5/6) short chain dehydrogenase
precursor_groups_19841 355.83 +- 229.17 2 0 0 0 0.03 +- 0.04 2 11

TIGR01296 (2/2) aspartate-semialdehyde dehydrogenase
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03466 (2/2) LysR substrate binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/2) B12 binding domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00892 (2/2) EamA-like transporter family
PF00696 (2/2) Amino acid kinase family
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_46378 105.30 +- 22.13 3 0 0 0 0.06 +- 0.02 3 4

PF03466 (3/3) LysR substrate binding domain
PF01979 (3/3) Amidohydrolase family
PF00756 (3/3) Putative esterase
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_41137 24.63 +- 5.72 2 0 0 0 0.09 +- 0.06 2 5

PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_groups_33831 264.25 +- 23.13 3 0 0 0 0.03 +- 0.02 3 7

PF13814 (3/3) Replication-relaxation
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_groups_12117 67.51 +- 6.49 6 0 6 0 0.12 +- 0.12 6 22

TIGR01733 (6/6) amino acid adenylation domain
TIGR01048 (6/6) diaminopimelate decarboxylase
PF16884 (6/6) N-terminal domain of oxidoreductase
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF14765 (6/6) Polyketide synthase dehydratase
PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08659 (6/6) KR domain
PF07690 (6/6) Major Facilitator Superfamily
PF04116 (6/6) Fatty acid hydroxylase superfamily
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02784 (6/6) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01593 (6/6) Flavin containing amine oxidoreductase
PF01266 (6/6) FAD dependent oxidoreductase
PF00975 (6/6) Thioesterase domain
PF00698 (6/6) Acyl transferase domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00107 (6/6) Zinc-binding dehydrogenase
PF00067 (6/6) Cytochrome P450
precursor_groups_58677 15.41 +- 2.73 2 0 0 0 0.13 +- 0.13 2 5

PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_groups_68007 220.60 +- 101.90 2 0 0 0 0.02 +- 0.02 2 6

PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00857 (2/2) Isochorismatase family
PF08448 (1/2) PAS fold
PF00582 (1/2) Universal stress protein family
precursor_groups_150 68.71 +- 48.53 256 0 41 256 0.17 +- 0.11 256 8

PF08530 (256/256) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (256/256) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR00976 (255/256) hydrolase CocE/NonD family protein
PF02129 (255/256) X-Pro dipeptidyl-peptidase (S15 family)
PF00005 (255/256) ABC transporter
PF01032 (251/256) FecCD transport family
PF01497 (248/256) Periplasmic binding protein
PF00664 (229/256) ABC transporter transmembrane region
precursor_groups_79421 112.24 +- 3.04 2 0 0 0 0.03 +- 0.03 2 6

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07519 (2/2) Tannase and feruloyl esterase
PF05685 (2/2) Putative restriction endonuclease
PF00589 (2/2) Phage integrase family
PF00501 (2/2) AMP-binding enzyme
precursor_groups_75352 1089.14 +- 716.86 2 0 2 0 0.02 +- 0.02 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17874 (2/2) MalT-like TPR region
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
precursor_groups_24236 40.45 +- 19.08 2 0 0 0 0.10 +- 0.16 2 6

TIGR00157 (2/2) ribosome small subunit-dependent GTPase A
PF13649 (2/2) Methyltransferase domain
PF07592 (2/2) Rhodopirellula transposase DDE domain
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF03193 (2/2) RsgA GTPase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_53351 129.59 +- 3.20 2 0 2 0 0.04 +- 0.04 2 17

TIGR01426 (2/2) glycosyltransferase, MGT family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13560 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08659 (2/2) KR domain
PF03060 (2/2) Nitronate monooxygenase
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_53031 53.08 +- 4.70 2 0 0 0 0.08 +- 0.08 2 4

TIGR02547 (2/2) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
PF13649 (2/2) Methyltransferase domain
PF09481 (2/2) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_groups_58474 518.00 +- 2.00 2 0 0 2 0.01 +- 0.00 2 5

TIGR03930 (2/2) WXG100 family type VII secretion target
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
precursor_groups_32118 570.07 +- 368.19 4 0 4 0 0.05 +- 0.03 4 25

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_5432 99.89 +- 23.99 6 0 1 0 0.23 +- 0.33 6 9

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF07811 (6/6) TadE-like protein
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
TIGR03177 (5/6) Flp pilus assembly protein CpaB
PF16976 (5/6) Flp pilus assembly protein RcpC/CpaB
PF13614 (5/6) AAA domain
PF00691 (5/6) OmpA family
PF02040 (4/6) Arsenical pump membrane protein
precursor_groups_22763 293.65 +- 226.35 2 0 0 0 0.03 +- 0.04 2 4

PF04199 (2/2) Putative cyclase
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_30630 15.79 +- 2.01 3 0 0 0 0.19 +- 0.22 3 3

PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00348 (3/3) Polyprenyl synthetase
precursor_groups_30634 148.59 +- 34.70 4 0 4 0 0.09 +- 0.18 4 12

PF13641 (4/4) Glycosyltransferase like family 2
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00925 (4/4) GTP cyclohydrolase II
PF00400 (4/4) WD domain, G-beta repeat
PF10823 (3/4) Protein of unknown function (DUF2568)
PF09335 (3/4) SNARE associated Golgi protein
PF01810 (3/4) LysE type translocator
PF00583 (3/4) Acetyltransferase (GNAT) family
PF00067 (3/4) Cytochrome P450
precursor_groups_8896 1102.46 +- 294.80 8 0 8 0 0.01 +- 0.00 8 8

TIGR01733 (8/8) amino acid adenylation domain
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF00975 (8/8) Thioesterase domain
PF00668 (8/8) Condensation domain
PF00561 (8/8) alpha/beta hydrolase fold
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00326 (8/8) Prolyl oligopeptidase family
precursor_groups_29822 501.48 +- 176.56 3 0 3 3 0.02 +- 0.01 3 7

PF16861 (3/3) Carbamoyltransferase C-terminus
PF12840 (3/3) Helix-turn-helix domain
PF04055 (3/3) Radical SAM superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
PF01546 (3/3) Peptidase family M20/M25/M40
PF00891 (3/3) O-methyltransferase domain
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_7056 415.04 +- 100.96 2 0 0 0 0.03 +- 0.04 2 16

TIGR02133 (1/2) ribose 5-phosphate isomerase
TIGR00791 (1/2) transporter, gluconate:H+ symporter (GntP) family
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13560 (1/2) Helix-turn-helix domain
PF12770 (1/2) CHAT domain
PF08007 (1/2) Cupin superfamily protein
PF07729 (1/2) FCD domain
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02734 (1/2) DAK2 domain
PF02733 (1/2) Dak1 domain
PF02502 (1/2) Ribose/Galactose Isomerase
PF02447 (1/2) GntP family permease
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_4022 83.35 +- 50.47 2 0 1 0 0.10 +- 0.23 2 17

TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (1/2) aminodeoxychorismate synthase, component I
PF13809 (1/2) Tubulin like
PF13545 (1/2) Crp-like helix-turn-helix domain
PF13452 (1/2) N-terminal half of MaoC dehydratase
PF11583 (1/2) P-aminobenzoate N-oxygenase AurF
PF04715 (1/2) Anthranilate synthase component I, N terminal region
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01575 (1/2) MaoC like domain
PF01063 (1/2) Amino-transferase class IV
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00425 (1/2) chorismate binding enzyme
PF00364 (1/2) Biotin-requiring enzyme
PF00117 (1/2) Glutamine amidotransferase class-I
PF00092 (1/2) von Willebrand factor type A domain
PF00027 (1/2) Cyclic nucleotide-binding domain
precursor_groups_24901 104.16 +- 31.25 4 0 0 0 0.03 +- 0.03 4 8

PF12697 (4/4) Alpha/beta hydrolase family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF00667 (4/4) FAD binding domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00258 (4/4) Flavodoxin
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00107 (4/4) Zinc-binding dehydrogenase
PF00067 (4/4) Cytochrome P450
precursor_groups_38000 59.58 +- 26.33 3 0 3 0 0.04 +- 0.03 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12840 (3/3) Helix-turn-helix domain
PF00501 (3/3) AMP-binding enzyme
precursor_groups_919 1524.55 +- 1127.40 3 0 0 0 0.01 +- 0.07 3 3

PF10145 (3/3) Phage-related minor tail protein
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
PF05133 (2/3) Phage portal protein, SPP1 Gp6-like
precursor_groups_42689 1292.60 +- 296.28 2 0 2 2 0.03 +- 0.02 2 9

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (2/2) Lantibiotic alpha
PF13575 (2/2) Domain of unknown function (DUF4135)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
precursor_groups_72835 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_44123 17.27 +- 3.94 2 0 0 0 0.18 +- 0.16 2 6

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09286 (2/2) Pro-kumamolisin, activation domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF02540 (2/2) NAD synthase
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00082 (2/2) Subtilase family
precursor_groups_42682 127.43 +- 19.00 3 0 0 3 0.13 +- 0.18 3 9

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF01494 (3/3) FAD binding domain
PF00881 (3/3) Nitroreductase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_42599 458.00 +- 289.51 3 0 3 3 0.04 +- 0.09 3 10

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF12804 (3/3) MobA-like NTP transferase domain
PF04055 (3/3) Radical SAM superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02310 (3/3) B12 binding domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_38484 31.25 +- 2.89 3 0 0 0 0.10 +- 0.06 3 7

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
precursor_groups_25834 139.20 +- 9.20 2 0 0 0 0.16 +- 0.28 2 11

TIGR01777 (2/2) TIGR01777 family protein
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13671 (2/2) AAA domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08338 (2/2) Domain of unknown function (DUF1731)
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_17418 1206.79 +- 1250.85 5 0 1 0 0.02 +- 0.03 5 13

PF17189 (5/5) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (5/5) Fibronectin type III-like domain
PF13416 (5/5) Bacterial extracellular solute-binding protein
PF13377 (5/5) Periplasmic binding protein-like domain
PF08244 (5/5) Glycosyl hydrolases family 32 C terminal
PF02055 (5/5) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (5/5) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (5/5) IPT/TIG domain
PF00933 (5/5) Glycosyl hydrolase family 3 N terminal domain
PF00754 (5/5) F5/8 type C domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00251 (5/5) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_42201 72.47 +- 33.08 2 0 0 0 0.05 +- 0.04 2 6

PF12802 (2/2) MarR family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05368 (2/2) NmrA-like family
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF08332 (1/2) Calcium/calmodulin dependent protein kinase II association domain
precursor_groups_42755 100.33 +- 20.27 3 0 0 0 0.02 +- 0.02 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme
precursor_groups_29282 2130.63 +- 486.38 4 0 3 0 0.01 +- 0.02 4 11

PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00535 (4/4) Glycosyl transferase family 2
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
TIGR01207 (2/4) glucose-1-phosphate thymidylyltransferase
PF00908 (2/4) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00483 (2/4) Nucleotidyl transferase
precursor_groups_40844 27.85 +- 4.40 2 0 0 0 0.11 +- 0.13 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF08751 (2/2) TrwC relaxase
PF03466 (2/2) LysR substrate binding domain
PF00872 (2/2) Transposase, Mutator family
PF00293 (2/2) NUDIX domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_12543 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_61335 164.67 +- 95.33 2 0 2 0 0.02 +- 0.03 2 3

PF02350 (2/2) UDP-N-acetylglucosamine 2-epimerase
PF00069 (2/2) Protein kinase domain
TIGR00236 (1/2) UDP-N-acetylglucosamine 2-epimerase
precursor_groups_63943 391.19 +- 95.33 2 0 0 0 0.03 +- 0.05 2 10

TIGR03356 (2/2) beta-galactosidase
PF13802 (2/2) Galactose mutarotase-like
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF02449 (2/2) Beta-galactosidase
PF01670 (2/2) Glycosyl hydrolase family 12
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_43081 68.38 +- 51.62 2 0 0 0 0.11 +- 0.15 2 12

PF05621 (2/2) Bacterial TniB protein
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13407 (1/2) Periplasmic binding protein domain
PF07729 (1/2) FCD domain
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (1/2) Glycosyl hydrolases family 43
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF01120 (1/2) Alpha-L-fucosidase
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00005 (1/2) ABC transporter
precursor_groups_61688 388.50 +- 1.50 2 0 0 2 0.01 +- 0.00 2 3

PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01266 (2/2) FAD dependent oxidoreductase
PF00881 (2/2) Nitroreductase family
precursor_groups_12285 387.67 +- 181.96 3 0 3 0 0.01 +- 0.00 3 4

PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00696 (3/3) Amino acid kinase family
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_61339 71.97 +- 1.42 2 0 0 0 0.14 +- 0.16 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_18888 41.86 +- 7.00 3 0 0 0 0.05 +- 0.04 3 5

PF16259 (3/3) Domain of unknown function (DUF4913)
PF12696 (3/3) TraM recognition site of TraD and TraG
PF02882 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01425 (3/3) Amidase
PF00763 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_18645 36.77 +- 3.68 2 0 0 0 0.19 +- 0.17 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_groups_74711 97.11 +- 11.53 2 0 0 0 0.17 +- 0.23 2 22

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02065 (2/2) Melibiase
PF01799 (2/2) [2Fe-2S] binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01081 (2/2) KDPG and KHG aldolase
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_31952 130.39 +- 74.88 4 0 0 0 0.03 +- 0.03 4 5

PF09130 (4/4) Domain of unknown function (DUF1932)
PF01471 (4/4) Putative peptidoglycan binding domain
PF12704 (3/4) MacB-like periplasmic core domain
PF02687 (3/4) FtsX-like permease family
PF00005 (3/4) ABC transporter
precursor_groups_6027 23.06 +- 27.39 11 0 3 0 0.16 +- 0.12 11 5

PF05331 (11/11) Protein of unknown function (DUF742)
PF03259 (11/11) Roadblock/LC7 domain
PF03029 (11/11) Conserved hypothetical ATP binding protein
PF00672 (11/11) HAMP domain
PF02518 (9/11) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_39994 455.00 +- 322.83 3 0 0 0 0.01 +- 0.00 3 2

PF12277 (3/3) Protein of unknown function (DUF3618)
PF07332 (3/3) Putative Actinobacterial Holin-X, holin superfamily III
precursor_groups_7055 302.42 +- 284.69 9 0 0 0 0.03 +- 0.06 9 5

TIGR03930 (9/9) WXG100 family type VII secretion target
PF06013 (9/9) Proteins of 100 residues with WXG
TIGR03921 (8/9) type VII secretion-associated serine protease mycosin
PF00082 (8/9) Subtilase family
PF05108 (7/9) Type VII secretion system ESX-1, transport TM domain B
precursor_groups_17891 347.40 +- 221.09 3 0 0 0 0.05 +- 0.18 3 9

TIGR02170 (3/3) thymidylate synthase, flavin-dependent
TIGR00730 (3/3) TIGR00730 family protein
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (3/3) ATP-grasp domain
PF03641 (3/3) Possible lysine decarboxylase
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02511 (3/3) Thymidylate synthase complementing protein
PF00106 (3/3) short chain dehydrogenase
precursor_groups_22369 69.46 +- 44.83 2 0 0 0 0.10 +- 0.07 2 12

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF18130 (2/2) ATP-grasp N-terminal domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF17802 (1/2) Prealbumin-like fold domain
precursor_groups_22028 15.09 +- 4.84 4 0 0 0 0.16 +- 0.16 4 3

PF08546 (4/4) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (4/4) Ketopantoate reductase PanE/ApbA
PF01568 (4/4) Molydopterin dinucleotide binding domain
precursor_groups_6442 227.62 +- 140.95 2 0 0 0 0.07 +- 0.07 2 7

PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF09848 (1/2) Uncharacterized conserved protein (DUF2075)
PF07690 (1/2) Major Facilitator Superfamily
PF01526 (1/2) Tn3 transposase DDE domain
PF01494 (1/2) FAD binding domain
PF00135 (1/2) Carboxylesterase family
precursor_groups_42374 212.96 +- 84.74 2 0 2 0 0.05 +- 0.07 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01510 (2/2) pantetheine-phosphate adenylyltransferase
PF13646 (2/2) HEAT repeats
PF13411 (2/2) MerR HTH family regulatory protein
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02310 (2/2) B12 binding domain
PF01467 (2/2) Cytidylyltransferase-like
PF00857 (2/2) Isochorismatase family
PF02607 (1/2) B12 binding domain
precursor_groups_6445 169.66 +- 73.88 7 1 0 1 0.14 +- 0.19 6 11

PF00005 (7/7) ABC transporter
TIGR02937 (6/7) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (6/7) virulence factor Mce family protein
PF13406 (6/7) Transglycosylase SLT domain
PF11887 (6/7) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (6/7) Sigma-70, region 4
PF04542 (6/7) Sigma-70 region 2
PF02470 (6/7) MlaD protein
PF02405 (6/7) Permease MlaE
PF16859 (5/7) Tetracyclin repressor-like, C-terminal domain
PF00440 (5/7) Bacterial regulatory proteins, tetR family
precursor_groups_54903 50.95 +- 2.43 2 0 0 0 0.21 +- 0.21 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF02777 (1/2) Iron/manganese superoxide dismutases, C-terminal domain
PF00081 (1/2) Iron/manganese superoxide dismutases, alpha-hairpin domain
precursor_groups_19204 38.53 +- 12.20 2 0 0 0 0.12 +- 0.10 2 9

PF18448 (2/2) Carbohydrate binding domain
PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF03442 (2/2) Carbohydrate binding domain X2
PF02449 (2/2) Beta-galactosidase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_22161 757.46 +- 843.88 3 0 0 0 0.09 +- 0.19 3 15

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00248 (3/3) Aldo/keto reductase family
PF00005 (3/3) ABC transporter
PF07920 (2/3) Protein of unknown function (DUF1684)
PF07690 (2/3) Major Facilitator Superfamily
PF05922 (2/3) Peptidase inhibitor I9
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00082 (2/3) Subtilase family
precursor_groups_22163 501.31 +- 144.56 3 0 0 0 0.02 +- 0.08 3 12

TIGR01554 (2/3) phage major capsid protein, HK97 family
TIGR01543 (2/3) phage prohead protease, HK97 family
TIGR01537 (2/3) phage portal protein, HK97 family
PF12307 (2/3) Protein of unknown function (DUF3631)
PF09250 (2/3) Bifunctional DNA primase/polymerase, N-terminal
PF05065 (2/3) Phage capsid family
PF04860 (2/3) Phage portal protein
PF04851 (2/3) Type III restriction enzyme, res subunit
PF04586 (2/3) Caudovirus prohead serine protease
PF01844 (2/3) HNH endonuclease
PF01510 (2/3) N-acetylmuramoyl-L-alanine amidase
PF00271 (2/3) Helicase conserved C-terminal domain
precursor_groups_49124 21.48 +- 7.72 2 0 0 0 0.12 +- 0.13 2 5

PF09335 (2/2) SNARE associated Golgi protein
PF07730 (2/2) Histidine kinase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_82617 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF05534 (2/2) HicB family
precursor_groups_43886 208.00 +- 159.49 3 0 0 0 0.03 +- 0.06 3 6

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01569 (3/3) PAP2 superfamily
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00282 (3/3) Pyridoxal-dependent decarboxylase conserved domain
PF00072 (3/3) Response regulator receiver domain
precursor_groups_82611 31.47 +- 5.98 2 0 0 0 0.08 +- 0.08 2 6

PF17269 (2/2) Family of unknown function (DUF5335)
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF00753 (2/2) Metallo-beta-lactamase superfamily
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_45933 595.10 +- 400.19 3 0 0 0 0.02 +- 0.02 3 8

TIGR00127 (3/3) isocitrate dehydrogenase, NADP-dependent
PF13343 (3/3) Bacterial extracellular solute-binding protein
PF12728 (3/3) Helix-turn-helix domain
PF08402 (3/3) TOBE domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00285 (3/3) Citrate synthase, C-terminal domain
PF00180 (3/3) Isocitrate/isopropylmalate dehydrogenase
PF00005 (3/3) ABC transporter
precursor_groups_3300 1684.33 +- 867.88 25 0 25 25 0.04 +- 0.06 25 11

TIGR01208 (25/25) glucose-1-phosphate thymidylyltransferase
PF13649 (25/25) Methyltransferase domain
PF05147 (25/25) Lanthionine synthetase C-like protein
PF00535 (25/25) Glycosyl transferase family 2
PF00483 (25/25) Nucleotidyl transferase
PF00465 (25/25) Iron-containing alcohol dehydrogenase
PF00296 (25/25) Luciferase-like monooxygenase
PF00202 (25/25) Aminotransferase class-III
PF00132 (25/25) Bacterial transferase hexapeptide (six repeats)
PF00069 (25/25) Protein kinase domain
PF00005 (25/25) ABC transporter
precursor_groups_3302 9.00 +- 0.00 2 0 0 0 0.22 +- 0.13 2 4

PF03471 (2/2) Transporter associated domain
PF01595 (2/2) Cyclin M transmembrane N-terminal domain
PF00582 (2/2) Universal stress protein family
PF00571 (2/2) CBS domain
precursor_groups_23369 48.88 +- 7.63 3 0 0 3 0.06 +- 0.06 3 3

PF10935 (3/3) Protein of unknown function (DUF2637)
PF07690 (3/3) Major Facilitator Superfamily
PF00881 (3/3) Nitroreductase family
precursor_groups_66790 82.62 +- 10.06 2 0 0 0 0.20 +- 0.08 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_3658 268.12 +- 209.09 17 0 17 0 0.15 +- 0.28 17 20

TIGR04462 (17/17) enduracididine biosynthesis enzyme MppP
TIGR04460 (17/17) enduracididine biosynthesis enzyme MppR
TIGR01733 (17/17) amino acid adenylation domain
TIGR01720 (17/17) non-ribosomal peptide synthase domain TIGR01720
PF13193 (17/17) AMP-binding enzyme C-terminal domain
PF12840 (17/17) Helix-turn-helix domain
PF07730 (17/17) Histidine kinase
PF06314 (17/17) Acetoacetate decarboxylase (ADC)
PF05977 (17/17) Transmembrane secretion effector
PF03621 (17/17) MbtH-like protein
PF02668 (17/17) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (17/17) Condensation domain
PF00550 (17/17) Phosphopantetheine attachment site
PF00501 (17/17) AMP-binding enzyme
PF00196 (17/17) Bacterial regulatory proteins, luxR family
PF00155 (17/17) Aminotransferase class I and II
PF00144 (17/17) Beta-lactamase
PF00072 (17/17) Response regulator receiver domain
PF00005 (17/17) ABC transporter
PF12698 (15/17) ABC-2 family transporter protein
precursor_groups_5305 485.05 +- 244.53 10 0 0 0 0.03 +- 0.03 10 10

TIGR03930 (10/10) WXG100 family type VII secretion target
TIGR03920 (10/10) type VII secretion integral membrane protein EccD
TIGR03919 (10/10) type VII secretion protein EccB
PF08817 (10/10) WXG100 protein secretion system (Wss), protein YukD
PF07179 (10/10) SseB protein N-terminal domain
PF06013 (10/10) Proteins of 100 residues with WXG
PF05108 (10/10) Type VII secretion system ESX-1, transport TM domain B
PF02575 (10/10) YbaB/EbfC DNA-binding family
PF00652 (10/10) Ricin-type beta-trefoil lectin domain
PF15644 (8/10) Papain fold toxin 1, glutamine deamidase
precursor_groups_72757 74.66 +- 5.34 2 0 1 0 0.08 +- 0.06 2 7

PF00857 (2/2) Isochorismatase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF14759 (1/2) Reductase C-terminal
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF00561 (1/2) alpha/beta hydrolase fold
PF00067 (1/2) Cytochrome P450
precursor_groups_22188 42.67 +- 9.06 5 0 0 0 0.07 +- 0.05 5 9

PF03450 (5/5) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (5/5) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (5/5) [2Fe-2S] binding domain
PF01315 (5/5) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (5/5) FAD binding domain in molybdopterin dehydrogenase
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF13478 (4/5) XdhC Rossmann domain
PF09339 (4/5) IclR helix-turn-helix domain
PF02625 (4/5) XdhC and CoxI family
precursor_groups_6537 39.00 +- 0.00 2 0 0 0 0.05 +- 0.03 2 2

PF05532 (2/2) CsbD-like
PF00106 (2/2) short chain dehydrogenase
precursor_groups_7009 26.92 +- 8.63 10 0 0 0 0.14 +- 0.14 10 5

PF16157 (10/10) Domain of unknown function (DUF4865)
PF07883 (10/10) Cupin domain
PF02126 (10/10) Phosphotriesterase family
PF00440 (10/10) Bacterial regulatory proteins, tetR family
PF13977 (6/10) BetI-type transcriptional repressor, C-terminal
precursor_groups_1921 704.86 +- 904.46 4 0 2 0 0.01 +- 0.02 4 10

TIGR03026 (2/4) nucleotide sugar dehydrogenase
PF13669 (2/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13641 (2/4) Glycosyltransferase like family 2
PF13520 (2/4) Amino acid permease
PF13088 (2/4) BNR repeat-like domain
PF04237 (2/4) YjbR
PF03721 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (2/4) Glycosyl transferase family 2
precursor_groups_11480 324.25 +- 46.50 3 0 3 0 0.01 +- 0.00 3 7

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_12604 148.65 +- 68.02 2 0 0 0 0.05 +- 0.05 2 10

TIGR04364 (1/2) methyltransferase, FxLD system
PF13565 (1/2) Homeodomain-like domain
PF13358 (1/2) DDE superfamily endonuclease
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF08244 (1/2) Glycosyl hydrolases family 32 C terminal
PF07859 (1/2) alpha/beta hydrolase fold
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00294 (1/2) pfkB family carbohydrate kinase
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_11482 764.63 +- 408.17 4 0 4 4 0.04 +- 0.17 4 8

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF13520 (4/4) Amino acid permease
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
precursor_groups_29995 104.14 +- 47.99 3 0 0 0 0.11 +- 0.09 3 7

PF12746 (3/3) GNAT acetyltransferase
PF11975 (3/3) Family 4 glycosyl hydrolase C-terminal domain
PF02056 (3/3) Family 4 glycosyl hydrolase
PF01833 (3/3) IPT/TIG domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_groups_26643 9.21 +- 0.68 3 0 0 0 0.22 +- 0.02 3 5

TIGR03802 (3/3) aspartate-alanine antiporter
TIGR03801 (3/3) aspartate 4-decarboxylase
PF06826 (3/3) Predicted Permease Membrane Region
PF02080 (3/3) TrkA-C domain
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_7799 947.35 +- 1001.55 3 0 0 0 0.04 +- 0.11 3 10

PF13814 (3/3) Replication-relaxation
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_groups_16466 273.59 +- 115.10 6 0 0 0 0.03 +- 0.01 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_groups_69237 22.81 +- 5.24 2 0 0 0 0.14 +- 0.12 2 5

PF08241 (2/2) Methyltransferase domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_groups_31516 110.74 +- 20.91 4 0 0 0 0.07 +- 0.04 4 12

TIGR03570 (4/4) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03025 (4/4) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF17836 (4/4) PglD N-terminal domain
PF13313 (4/4) Domain of unknown function (DUF4082)
PF13205 (4/4) Bacterial Ig-like domain
PF02397 (4/4) Bacterial sugar transferase
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (4/4) Glycosyl transferase family 2
PF03404 (3/4) Mo-co oxidoreductase dimerisation domain
PF00132 (3/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_52644 72.29 +- 2.49 2 0 0 0 0.14 +- 0.30 2 11

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF16864 (2/2) Dimerisation domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF07690 (2/2) Major Facilitator Superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_34033 61.08 +- 9.71 2 0 0 0 0.15 +- 0.29 2 9

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_34744 289.97 +- 226.03 2 0 0 0 0.06 +- 0.08 2 7

PF04961 (2/2) Formiminotransferase-cyclodeaminase
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01885 (2/2) RNA 2'-phosphotransferase, Tpt1 / KptA family
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF13586 (1/2) Transposase DDE domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF00561 (1/2) alpha/beta hydrolase fold
precursor_groups_41831 445.71 +- 74.29 2 0 2 0 0.01 +- 0.00 2 8

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_groups_3279 719.48 +- 312.52 2 0 2 0 0.02 +- 0.01 2 8

PF13452 (2/2) N-terminal half of MaoC dehydratase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF01575 (2/2) MaoC like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00890 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_27595 460.22 +- 221.87 3 0 0 0 0.02 +- 0.01 3 8

PF14759 (3/3) Reductase C-terminal
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00866 (3/3) Ring hydroxylating beta subunit
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00106 (3/3) short chain dehydrogenase
precursor_groups_27598 182.92 +- 27.92 3 0 3 0 0.17 +- 0.34 3 11

PF13424 (3/3) Tetratricopeptide repeat
PF06259 (3/3) Alpha/beta hydrolase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01757 (3/3) Acyltransferase family
PF01177 (3/3) Asp/Glu/Hydantoin racemase
PF01061 (3/3) ABC-2 type transporter
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_54112 435.50 +- 84.50 2 0 0 0 0.02 +- 0.02 2 5

PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03640 (2/2) Secreted repeat of unknown function
PF14246 (1/2) AefR-like transcriptional repressor, C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_28559 104.04 +- 12.83 3 0 0 0 0.03 +- 0.02 3 6

PF12697 (3/3) Alpha/beta hydrolase family
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF01494 (3/3) FAD binding domain
PF01262 (3/3) Alanine dehydrogenase/PNT, C-terminal domain
PF02909 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_23442 18.87 +- 6.29 2 0 0 0 0.24 +- 0.19 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF03664 (2/2) Glycosyl hydrolase family 62
PF01341 (2/2) Glycosyl hydrolases family 6
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_7770 13.41 +- 3.79 2 0 0 0 0.16 +- 0.31 2 3

TIGR01179 (2/2) UDP-glucose 4-epimerase GalE
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_82754 172.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 2

PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF03713 (2/2) Domain of unknown function (DUF305)
precursor_groups_8792 14.30 +- 1.07 8 0 3 0 0.21 +- 0.04 8 6

PF13247 (8/8) 4Fe-4S dicluster domain
PF04879 (8/8) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (8/8) Molydopterin dinucleotide binding domain
PF00384 (8/8) Molybdopterin oxidoreductase
PF00355 (8/8) Rieske [2Fe-2S] domain
PF00037 (8/8) 4Fe-4S binding domain
precursor_groups_9975 27.19 +- 1.79 3 0 0 0 0.22 +- 0.23 3 5

PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00005 (3/3) ABC transporter
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF01152 (2/3) Bacterial-like globin
precursor_groups_4204 458.64 +- 410.17 12 0 0 0 0.04 +- 0.08 12 15

PF18565 (12/12) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (12/12) Domain of unknown function (DUF4982)
PF14310 (12/12) Fibronectin type III-like domain
PF07859 (12/12) alpha/beta hydrolase fold
PF02837 (12/12) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (12/12) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (12/12) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (12/12) Glycosyl hydrolase family 3 N terminal domain
PF00703 (12/12) Glycosyl hydrolases family 2
PF00135 (12/12) Carboxylesterase family
PF00106 (12/12) short chain dehydrogenase
PF17390 (11/12) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (11/12) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (11/12) Alpha-L-rhamnosidase N-terminal domain
PF05592 (11/12) Bacterial alpha-L-rhamnosidase concanavalin-like domain
precursor_groups_77026 664.57 +- 367.43 2 0 2 0 0.02 +- 0.02 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_32548 133.55 +- 28.95 2 0 0 0 0.09 +- 0.12 2 8

PF11758 (2/2) Aureocin-like type II bacteriocin
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
precursor_groups_69944 37.32 +- 9.95 2 0 2 0 0.12 +- 0.09 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator
precursor_groups_22210 20.85 +- 0.07 2 0 0 0 0.19 +- 0.35 2 7

PF17996 (2/2) Carbohydrate esterase 2 N-terminal
PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01012 (2/2) Electron transfer flavoprotein domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
precursor_groups_40050 58.50 +- 1.38 3 0 3 0 0.15 +- 0.34 3 9

PF17926 (3/3) Tetracyclin repressor-like, C-terminal domain
PF13822 (3/3) Acyl-CoA carboxylase epsilon subunit
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13411 (3/3) MerR HTH family regulatory protein
PF09278 (3/3) MerR, DNA binding
PF07690 (3/3) Major Facilitator Superfamily
PF01361 (3/3) Tautomerase enzyme
PF01039 (3/3) Carboxyl transferase domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_23561 667.24 +- 335.44 5 0 5 0 0.03 +- 0.06 5 14

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12832 (5/5) MFS_1 like family
PF01212 (5/5) Beta-eliminating lyase
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00156 (5/5) Phosphoribosyl transferase domain
PF00067 (5/5) Cytochrome P450
TIGR00229 (3/5) PAS domain S-box protein
PF08448 (3/5) PAS fold
PF07228 (3/5) Stage II sporulation protein E (SpoIIE)
PF01814 (3/5) Hemerythrin HHE cation binding domain
PF01590 (3/5) GAF domain
PF00989 (3/5) PAS fold
precursor_groups_26262 126.63 +- 34.90 2 0 2 0 0.12 +- 0.15 2 7

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_21748 452.75 +- 127.75 2 0 0 2 0.01 +- 0.00 2 7

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF10014 (2/2) 2OG-Fe dioxygenase
PF07690 (2/2) Major Facilitator Superfamily
PF04828 (2/2) Glutathione-dependent formaldehyde-activating enzyme
PF04055 (2/2) Radical SAM superfamily
PF00487 (2/2) Fatty acid desaturase
precursor_groups_27600 129.88 +- 18.32 4 0 0 0 0.10 +- 0.07 4 16

PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
TIGR01182 (3/4) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (3/4) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (3/4) Alpha galactosidase A
precursor_groups_81410 1580.73 +- 635.73 2 0 2 0 0.02 +- 0.04 2 14

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
precursor_groups_59052 53.35 +- 6.08 2 0 2 2 0.08 +- 0.06 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF00704 (2/2) Glycosyl hydrolases family 18
PF00553 (2/2) Cellulose binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00041 (2/2) Fibronectin type III domain
precursor_groups_37109 63.30 +- 31.37 3 0 0 0 0.15 +- 0.29 3 6

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13302 (2/3) Acetyltransferase (GNAT) domain
PF07690 (2/3) Major Facilitator Superfamily
PF03435 (2/3) Saccharopine dehydrogenase NADP binding domain
PF00313 (2/3) 'Cold-shock' DNA-binding domain
PF00204 (2/3) DNA gyrase B
precursor_groups_11734 43.50 +- 23.93 5 0 0 0 0.19 +- 0.19 5 9

TIGR00505 (5/5) GTP cyclohydrolase II
PF03706 (5/5) Lysylphosphatidylglycerol synthase TM region
PF01242 (5/5) 6-pyruvoyl tetrahydropterin synthase
PF00925 (5/5) GTP cyclohydrolase II
PF00534 (5/5) Glycosyl transferases group 1
PF16653 (4/5) Saccharopine dehydrogenase C-terminal domain
PF05222 (4/5) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (4/5) Saccharopine dehydrogenase NADP binding domain
PF01266 (4/5) FAD dependent oxidoreductase
precursor_groups_45801 36.03 +- 2.32 3 0 3 0 0.14 +- 0.25 3 6

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04030 (3/3) D-arabinono-1,4-lactone oxidase
PF01565 (3/3) FAD binding domain
PF01522 (3/3) Polysaccharide deacetylase
PF00248 (3/3) Aldo/keto reductase family
PF00106 (3/3) short chain dehydrogenase
precursor_groups_11739 9.00 +- 0.00 2 0 0 0 0.22 +- 0.15 2 2

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
precursor_groups_3787 54.58 +- 12.68 10 0 0 0 0.19 +- 0.15 10 8

TIGR01509 (10/10) HAD hydrolase, family IA, variant 3
PF13419 (10/10) Haloacid dehalogenase-like hydrolase
PF13343 (10/10) Bacterial extracellular solute-binding protein
PF08402 (10/10) TOBE domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00005 (10/10) ABC transporter
PF03372 (9/10) Endonuclease/Exonuclease/phosphatase family
PF07690 (7/10) Major Facilitator Superfamily
precursor_groups_10606 3604.65 +- 2056.65 2 0 1 0 0.01 +- 0.01 2 28

TIGR03618 (1/2) PPOX class probable F420-dependent enzyme
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF17914 (1/2) HopA1 effector protein family
PF17837 (1/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12698 (1/2) ABC-2 family transporter protein
PF07977 (1/2) FabA-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02441 (1/2) Flavoprotein
PF02384 (1/2) N-6 DNA Methylase
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (1/2) Phosphotransferase enzyme family
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00891 (1/2) O-methyltransferase domain
PF00698 (1/2) Acyl transferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00296 (1/2) Luciferase-like monooxygenase
PF00293 (1/2) NUDIX domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00005 (1/2) ABC transporter
precursor_groups_41557 47.40 +- 14.45 2 0 0 0 0.12 +- 0.27 2 6

TIGR01179 (2/2) UDP-glucose 4-epimerase GalE
PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00535 (2/2) Glycosyl transferase family 2
PF00005 (2/2) ABC transporter
precursor_groups_37139 81.02 +- 28.93 3 0 3 0 0.13 +- 0.23 3 12

PF13924 (3/3) Lipocalin-like domain
PF12697 (3/3) Alpha/beta hydrolase family
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF04673 (3/3) Polyketide synthesis cyclase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00106 (3/3) short chain dehydrogenase
PF00072 (3/3) Response regulator receiver domain
precursor_groups_50268 390.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 6

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_33543 150.03 +- 21.03 2 0 1 0 0.03 +- 0.01 2 6

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_28440 466.31 +- 283.25 3 0 0 0 0.10 +- 0.26 3 14

TIGR01850 (3/3) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (3/3) alpha-L-glutamate ligase, RimK family
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08443 (3/3) RimK-like ATP-grasp domain
PF02812 (3/3) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (3/3) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (3/3) Amino acid kinase family
PF00682 (3/3) HMGL-like
PF00501 (3/3) AMP-binding enzyme
PF00208 (3/3) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00155 (3/3) Aminotransferase class I and II
PF00117 (3/3) Glutamine amidotransferase class-I
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_64027 23.69 +- 4.82 2 0 0 0 0.21 +- 0.35 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00178 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF03971 (2/2) Monomeric isocitrate dehydrogenase
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00248 (2/2) Aldo/keto reductase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF07690 (1/2) Major Facilitator Superfamily
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_23740 211.91 +- 0.82 2 0 0 0 0.03 +- 0.03 2 3

PF08241 (2/2) Methyltransferase domain
PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
precursor_groups_10195 200.24 +- 59.56 8 0 0 8 0.03 +- 0.01 8 5

PF08282 (8/8) haloacid dehalogenase-like hydrolase
PF04339 (8/8) Peptidogalycan biosysnthesis/recognition
PF04055 (8/8) Radical SAM superfamily
PF00303 (8/8) Thymidylate synthase
PF13480 (6/8) Acetyltransferase (GNAT) domain
precursor_groups_4372 51.38 +- 30.25 3 0 0 0 0.16 +- 0.29 3 8

TIGR01788 (2/3) glutamate decarboxylase
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13560 (2/3) Helix-turn-helix domain
PF13365 (2/3) Trypsin-like peptidase domain
PF10901 (2/3) Protein of unknown function (DUF2690)
PF07690 (2/3) Major Facilitator Superfamily
PF03358 (2/3) NADPH-dependent FMN reductase
PF00282 (2/3) Pyridoxal-dependent decarboxylase conserved domain
precursor_groups_694 203.25 +- 449.84 10 0 0 0 0.14 +- 0.18 10

No common domains found
precursor_groups_4379 266.09 +- 253.91 2 0 1 0 0.09 +- 0.25 2 18

TIGR00879 (1/2) MFS transporter, sugar porter (SP) family
TIGR00745 (1/2) 2-dehydropantoate 2-reductase
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal
PF08242 (1/2) Methyltransferase domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF01471 (1/2) Putative peptidoglycan binding domain
PF00698 (1/2) Acyl transferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00171 (1/2) Aldehyde dehydrogenase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00083 (1/2) Sugar (and other) transporter
PF00067 (1/2) Cytochrome P450
precursor_groups_82849 16.99 +- 7.20 2 0 0 0 0.14 +- 0.08 2 4

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_8409 9.43 +- 0.38 2 0 2 0 0.21 +- 0.01 2 5

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
precursor_groups_10280 49.83 +- 25.11 4 0 0 0 0.18 +- 0.20 4 8

TIGR03718 (4/4) integral membrane protein, TerC family
PF13407 (4/4) Periplasmic binding protein domain
PF05331 (4/4) Protein of unknown function (DUF742)
PF03741 (4/4) Integral membrane protein TerC family
PF03259 (4/4) Roadblock/LC7 domain
PF03029 (4/4) Conserved hypothetical ATP binding protein
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF18029 (2/4) Glyoxalase-like domain
precursor_groups_70943 701.46 +- 219.97 2 0 0 2 0.02 +- 0.02 2 8

TIGR04267 (2/2) HEXXH motif domain
TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF04055 (2/2) Radical SAM superfamily
PF02223 (2/2) Thymidylate kinase
PF00293 (2/2) NUDIX domain
PF00248 (2/2) Aldo/keto reductase family
PF00144 (2/2) Beta-lactamase
PF00069 (2/2) Protein kinase domain
precursor_groups_69053 111.59 +- 1.41 2 0 0 0 0.18 +- 0.31 2 10

PF18844 (2/2) Bacterial archaeo-eukaryotic release factor family 2
PF13847 (2/2) Methyltransferase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF11387 (2/2) Protein of unknown function (DUF2795)
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF01569 (2/2) PAP2 superfamily
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_81708 258.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 3

PF13649 (2/2) Methyltransferase domain
PF13460 (2/2) NAD(P)H-binding
PF01494 (2/2) FAD binding domain
precursor_groups_37210 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_81706 490.20 +- 25.80 2 0 0 0 0.02 +- 0.02 2 18

TIGR03086 (1/2) TIGR03086 family protein
TIGR02960 (1/2) RNA polymerase sigma-70 factor, TIGR02960 family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14310 (1/2) Fibronectin type III-like domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF12680 (1/2) SnoaL-like domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08281 (1/2) Sigma-70, region 4
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF06271 (1/2) RDD family
PF04892 (1/2) VanZ like family
PF04542 (1/2) Sigma-70 region 2
PF02698 (1/2) DUF218 domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00106 (1/2) short chain dehydrogenase
precursor_groups_45338 2338.97 +- 241.03 2 0 0 0 0.01 +- 0.02 2 10

PF12680 (2/2) SnoaL-like domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00005 (2/2) ABC transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01494 (1/2) FAD binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_86350 1342.00 +- 1238.00 2 0 2 0 0.07 +- 0.23 2 19

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00083 (2/2) Sugar (and other) transporter
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01751 (1/2) crotonyl-CoA carboxylase/reductase
PF16864 (1/2) Dimerisation domain
PF08241 (1/2) Methyltransferase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00668 (1/2) Condensation domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_31621 93.21 +- 39.02 4 0 0 0 0.04 +- 0.05 4 3

PF08028 (3/4) Acyl-CoA dehydrogenase, C-terminal domain
PF04229 (3/4) GrpB protein
PF01979 (3/4) Amidohydrolase family
precursor_groups_3873 382.91 +- 195.96 3 0 0 0 0.03 +- 0.04 3 9

PF09339 (3/3) IclR helix-turn-helix domain
PF03466 (3/3) LysR substrate binding domain
PF01614 (3/3) Bacterial transcriptional regulator
PF01522 (3/3) Polysaccharide deacetylase
PF00561 (3/3) alpha/beta hydrolase fold
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family
PF02776 (2/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
precursor_groups_28482 81.71 +- 56.95 2 0 0 0 0.10 +- 0.11 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF11239 (2/2) Protein of unknown function (DUF3040)
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_15038 42.27 +- 12.04 2 0 0 0 0.10 +- 0.11 2 5

PF13546 (2/2) DDE superfamily endonuclease
PF13361 (2/2) UvrD-like helicase C-terminal domain
PF13245 (2/2) AAA domain
PF04264 (2/2) YceI-like domain
PF00069 (2/2) Protein kinase domain
precursor_groups_3877 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF04321 (2/2) RmlD substrate binding domain
PF02719 (2/2) Polysaccharide biosynthesis protein
PF00069 (2/2) Protein kinase domain
precursor_groups_14035 122.14 +- 7.98 3 0 1 0 0.23 +- 0.32 3 9

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF02040 (2/3) Arsenical pump membrane protein
PF00691 (2/3) OmpA family
precursor_groups_47551 311.06 +- 166.74 3 0 0 0 0.02 +- 0.01 3 10

PF16349 (3/3) Domain of unknown function (DUF4978)
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF14100 (3/3) Methane oxygenase PmoA
PF13377 (3/3) Periplasmic binding protein-like domain
PF13338 (3/3) Transcriptional regulator, AbiEi antitoxin
PF07883 (3/3) Cupin domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_14294 661.60 +- 631.16 7 0 7 0 0.04 +- 0.11 7 11

TIGR01509 (7/7) HAD hydrolase, family IA, variant 3
TIGR00652 (7/7) diaminopimelate epimerase
PF18130 (7/7) ATP-grasp N-terminal domain
PF14518 (7/7) Iron-containing redox enzyme
PF13535 (7/7) ATP-grasp domain
PF13419 (7/7) Haloacid dehalogenase-like hydrolase
PF10014 (7/7) 2OG-Fe dioxygenase
PF07690 (7/7) Major Facilitator Superfamily
PF02585 (7/7) GlcNAc-PI de-N-acetylase
PF01678 (7/7) Diaminopimelate epimerase
PF00155 (7/7) Aminotransferase class I and II
precursor_groups_67772 70.56 +- 11.54 2 0 0 0 0.15 +- 0.14 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF02342 (2/2) TerD domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_23638 39.11 +- 4.63 3 0 3 0 0.13 +- 0.22 3 9

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_23635 518.00 +- 2.00 4 0 0 0 0.01 +- 0.00 4 7

PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF05141 (4/4) Pyoverdine/dityrosine biosynthesis protein
PF04820 (4/4) Tryptophan halogenase
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01565 (4/4) FAD binding domain
TIGR01509 (3/4) HAD hydrolase, family IA, variant 3
precursor_groups_73375 66.14 +- 25.62 2 0 0 0 0.11 +- 0.13 2 6

PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_46683 1573.84 +- 732.99 2 0 2 0 0.02 +- 0.03 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01214 (2/2) dTDP-4-dehydrorhamnose reductase
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16861 (2/2) Carbamoyltransferase C-terminus
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF08484 (2/2) C-methyltransferase C-terminal domain
PF08421 (2/2) Putative zinc binding domain
PF06722 (2/2) Protein of unknown function (DUF1205)
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04321 (2/2) RmlD substrate binding domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02195 (2/2) ParB-like nuclease domain
PF02153 (2/2) Prephenate dehydrogenase
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_groups_1431 59.40 +- 51.72 6 0 1 0 0.11 +- 0.21 6 4

PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain
PF07730 (4/6) Histidine kinase
PF13649 (3/6) Methyltransferase domain
precursor_groups_1432 29.64 +- 5.15 4 0 1 0 0.17 +- 0.19 4 11

PF13478 (4/4) XdhC Rossmann domain
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF06240 (4/4) Carbon monoxide dehydrogenase subunit G (CoxG)
PF05762 (4/4) VWA domain containing CoxE-like protein
PF03450 (4/4) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (4/4) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (4/4) XdhC and CoxI family
PF01799 (4/4) [2Fe-2S] binding domain
PF01315 (4/4) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (4/4) FAD binding domain in molybdopterin dehydrogenase
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_67061 68.53 +- 4.03 2 0 0 0 0.04 +- 0.03 2 5

PF17479 (2/2) Protein of unknown function (DUF3048) C-terminal domain
PF13411 (2/2) MerR HTH family regulatory protein
PF11258 (2/2) Protein of unknown function (DUF3048) N-terminal domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_20101 302.67 +- 130.67 2 0 2 2 0.02 +- 0.02 2 5

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF00067 (2/2) Cytochrome P450
PF02310 (1/2) B12 binding domain
precursor_groups_21455 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_50863 9.08 +- 0.06 2 0 2 0 0.22 +- 0.39 2 4

PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
PF00089 (2/2) Trypsin
precursor_groups_8330 171.31 +- 108.82 6 0 6 0 0.17 +- 0.22 6 14

TIGR01733 (6/6) amino acid adenylation domain
TIGR01720 (6/6) non-ribosomal peptide synthase domain TIGR01720
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF07690 (6/6) Major Facilitator Superfamily
PF01382 (6/6) Avidin family
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00106 (6/6) short chain dehydrogenase
TIGR01727 (3/6) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (3/6) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00496 (3/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/6) ABC transporter
precursor_groups_20109 213.18 +- 122.47 4 0 0 0 0.01 +- 0.01 4 3

PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF01120 (4/4) Alpha-L-fucosidase
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
precursor_groups_63015 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_31727 44.01 +- 3.88 2 0 2 0 0.09 +- 0.18 2 4

TIGR00377 (2/2) anti-anti-sigma factor
PF01740 (2/2) STAS domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_27852 369.14 +- 281.83 4 0 0 0 0.09 +- 0.19 4 11

TIGR01426 (4/4) glycosyltransferase, MGT family
PF00535 (4/4) Glycosyl transferase family 2
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00089 (4/4) Trypsin
PF00082 (4/4) Subtilase family
PF13546 (3/4) DDE superfamily endonuclease
PF13385 (3/4) Concanavalin A-like lectin/glucanases superfamily
PF07591 (3/4) Pretoxin HINT domain
PF04471 (3/4) Restriction endonuclease
PF03752 (3/4) Short repeats of unknown function
PF03009 (3/4) Glycerophosphoryl diester phosphodiesterase family
precursor_groups_50774 1057.64 +- 490.36 2 0 2 2 0.01 +- 0.02 2 9

TIGR04353 (2/2) PqqD family protein, HPr-rel-A system
PF13646 (2/2) HEAT repeats
PF13471 (2/2) Transglutaminase-like superfamily
PF13411 (2/2) MerR HTH family regulatory protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_15102 265.18 +- 68.33 6 0 0 0 0.06 +- 0.06 6 7

PF17851 (6/6) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF04616 (6/6) Glycosyl hydrolases family 43
PF02826 (6/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
precursor_groups_20859 88.43 +- 21.02 2 0 0 0 0.03 +- 0.04 2 9

TIGR01840 (2/2) esterase, PHB depolymerase family
PF18143 (2/2) HAD domain in Swiss Army Knife RNA repair proteins
PF13279 (2/2) Thioesterase-like superfamily
PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF09362 (2/2) Domain of unknown function (DUF1996)
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF03713 (2/2) Domain of unknown function (DUF305)
precursor_groups_33358 483.60 +- 137.88 3 0 0 0 0.05 +- 0.05 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_groups_10466 65.82 +- 0.00 2 0 0 0 0.15 +- 0.17 2 9

TIGR03723 (2/2) tRNA threonylcarbamoyl adenosine modification protein TsaD
TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02272 (2/2) DHHA1 domain
PF01475 (2/2) Ferric uptake regulator family
PF01411 (2/2) tRNA synthetases class II (A)
PF00814 (2/2) Glycoprotease family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_8247 69.31 +- 24.13 5 0 0 0 0.03 +- 0.02 5 2

PF00106 (5/5) short chain dehydrogenase
PF01757 (4/5) Acyltransferase family
precursor_groups_8249 126.29 +- 59.43 2 0 0 0 0.05 +- 0.08 2 9

PF10935 (2/2) Protein of unknown function (DUF2637)
PF07702 (2/2) UTRA domain
PF01580 (2/2) FtsK/SpoIIIE family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13148 (1/2) Protein of unknown function (DUF3987)
PF12728 (1/2) Helix-turn-helix domain
PF11750 (1/2) Protein of unknown function (DUF3307)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF00589 (1/2) Phage integrase family
precursor_groups_83493 194.50 +- 65.50 2 0 0 0 0.01 +- 0.00 2 5

TIGR03026 (2/2) nucleotide sugar dehydrogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_50912 1272.69 +- 677.31 2 0 1 0 0.01 +- 0.01 2 10

PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01569 (2/2) PAP2 superfamily
PF01061 (2/2) ABC-2 type transporter
PF00550 (2/2) Phosphopantetheine attachment site
PF00005 (2/2) ABC transporter
TIGR01179 (1/2) UDP-glucose 4-epimerase GalE
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00534 (1/2) Glycosyl transferases group 1
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_9334 93.20 +- 26.88 6 0 1 0 0.04 +- 0.02 6 6

PF12697 (6/6) Alpha/beta hydrolase family
PF07729 (6/6) FCD domain
PF06684 (6/6) Amino acid synthesis
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF00296 (6/6) Luciferase-like monooxygenase
PF00171 (6/6) Aldehyde dehydrogenase family
precursor_groups_16355 405.84 +- 161.12 6 0 1 6 0.01 +- 0.03 6 7

TIGR00702 (6/6) YcaO-type kinase domain
PF13489 (6/6) Methyltransferase domain
PF07812 (6/6) TfuA-like protein
PF07690 (6/6) Major Facilitator Superfamily
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF18029 (5/6) Glyoxalase-like domain
PF13231 (5/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
precursor_groups_657 12.34 +- 0.24 2 0 0 0 0.21 +- 0.23 2 4

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13439 (2/2) Glycosyltransferase Family 4
PF00534 (2/2) Glycosyl transferases group 1
PF01494 (1/2) FAD binding domain
precursor_groups_19 232.87 +- 202.51 2 0 0 1 0.07 +- 0.23 2 10

PF04149 (2/2) Domain of unknown function (DUF397)
PF13599 (1/2) Pentapeptide repeats (9 copies)
PF13560 (1/2) Helix-turn-helix domain
PF13354 (1/2) Beta-lactamase enzyme family
PF08241 (1/2) Methyltransferase domain
PF07702 (1/2) UTRA domain
PF05576 (1/2) PS-10 peptidase S37
PF04055 (1/2) Radical SAM superfamily
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
precursor_groups_18 275.02 +- 539.09 40 0 2 3 0.12 +- 0.25 40 1

PF00005 (25/40) ABC transporter
precursor_groups_57594 287.38 +- 128.62 2 0 2 0 0.02 +- 0.02 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF07730 (2/2) Histidine kinase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00122 (2/2) E1-E2 ATPase
PF00072 (2/2) Response regulator receiver domain
precursor_groups_13 161.42 +- 172.65 23 0 4 1 0.09 +- 0.21 23 2

PF13560 (21/23) Helix-turn-helix domain
PF04149 (21/23) Domain of unknown function (DUF397)
precursor_groups_12 111.95 +- 198.77 31 0 2 1 0.09 +- 0.18 31

No common domains found
precursor_groups_11 69.56 +- 56.37 8 0 3 0 0.16 +- 0.27 8 1

PF00313 (8/8) 'Cold-shock' DNA-binding domain
precursor_groups_1327 22.25 +- 12.92 3 0 0 0 0.19 +- 0.21 3 6

PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/3) Enolase C-terminal domain-like
PF13304 (2/3) AAA domain, putative AbiEii toxin, Type IV TA system
PF02746 (2/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (2/3) Fumarylacetoacetate (FAA) hydrolase family
PF00248 (2/3) Aldo/keto reductase family
precursor_groups_4792 156.67 +- 72.92 6 0 0 6 0.07 +- 0.18 6 10

TIGR04276 (6/6) FxsC C-terminal domain
TIGR04269 (6/6) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (6/6) FXSXX-COOH protein
TIGR04267 (6/6) HEXXH motif domain
PF13676 (6/6) TIR domain
PF13424 (6/6) Tetratricopeptide repeat
PF04055 (6/6) Radical SAM superfamily
PF01656 (6/6) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (6/6) NB-ARC domain
PF13374 (4/6) Tetratricopeptide repeat
precursor_groups_16 23.48 +- 4.68 2 0 1 0 0.19 +- 0.32 2 20

PF00313 (2/2) 'Cold-shock' DNA-binding domain
TIGR02258 (1/2) 2'-5' RNA ligase
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13714 (1/2) Phosphoenolpyruvate phosphomutase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12840 (1/2) Helix-turn-helix domain
PF08327 (1/2) Activator of Hsp90 ATPase homolog 1-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF04244 (1/2) Deoxyribodipyrimidine photo-lyase-related protein
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02898 (1/2) Nitric oxide synthase, oxygenase domain
PF02834 (1/2) LigT like Phosphoesterase
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02146 (1/2) Sir2 family
PF00970 (1/2) Oxidoreductase FAD-binding domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00042 (1/2) Globin
precursor_groups_15 293.10 +- 440.73 396 0 386 0 0.11 +- 0.23 396 7

PF03621 (395/396) MbtH-like protein
PF00550 (339/396) Phosphopantetheine attachment site
PF00501 (337/396) AMP-binding enzyme
TIGR01733 (332/396) amino acid adenylation domain
PF13193 (330/396) AMP-binding enzyme C-terminal domain
PF00668 (320/396) Condensation domain
PF00975 (253/396) Thioesterase domain
precursor_groups_45664 396.67 +- 119.33 2 0 2 0 0.01 +- 0.00 2 8

TIGR00052 (2/2) nudix-type nucleoside diphosphatase, YffH/AdpP family
PF13855 (2/2) Leucine rich repeat
PF13516 (2/2) Leucine Rich repeat
PF07690 (2/2) Major Facilitator Superfamily
PF02641 (2/2) Uncharacterized ACR, COG1993
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
precursor_groups_16470 129.00 +- 83.47 2 0 0 0 0.08 +- 0.09 2 9

TIGR01428 (2/2) haloacid dehalogenase, type II
PF12973 (2/2) ChrR Cupin-like domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF07690 (2/2) Major Facilitator Superfamily
PF01909 (2/2) Nucleotidyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00144 (2/2) Beta-lactamase
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_26888 39.76 +- 24.43 4 0 0 0 0.15 +- 0.25 4 5

PF11127 (4/4) Protein of unknown function (DUF2892)
PF01925 (4/4) Sulfite exporter TauE/SafE
PF00753 (4/4) Metallo-beta-lactamase superfamily
PF00581 (4/4) Rhodanese-like domain
PF02583 (3/4) Metal-sensitive transcriptional repressor
precursor_groups_5331 81.70 +- 47.30 2 0 0 0 0.03 +- 0.03 2 7

PF17342 (1/2) Family of unknown function (DUF5372)
PF13408 (1/2) Recombinase zinc beta ribbon domain
PF07508 (1/2) Recombinase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF06925 (1/2) Monogalactosyldiacylglycerol (MGDG) synthase
PF01522 (1/2) Polysaccharide deacetylase
PF00239 (1/2) Resolvase, N terminal domain
precursor_groups_73848 10.41 +- 2.17 2 0 2 0 0.20 +- 0.09 2 4

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13489 (2/2) Methyltransferase domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_39050 85.16 +- 50.82 3 0 0 0 0.11 +- 0.25 3 14

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14525 (3/3) AraC-binding-like domain
PF13458 (3/3) Periplasmic binding protein
PF12840 (3/3) Helix-turn-helix domain
PF12833 (3/3) Helix-turn-helix domain
PF11774 (3/3) Lsr2
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit
PF01425 (3/3) Amidase
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_groups_11661 784.78 +- 333.12 8 0 0 0 0.02 +- 0.01 8 9

PF17765 (8/8) MmyB-like transcription regulator ligand binding domain
PF13560 (8/8) Helix-turn-helix domain
PF10935 (8/8) Protein of unknown function (DUF2637)
PF08666 (8/8) SAF domain
PF07811 (8/8) TadE-like protein
PF01476 (8/8) LysM domain
PF00753 (8/8) Metallo-beta-lactamase superfamily
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF00437 (8/8) Type II/IV secretion system protein
precursor_groups_32080 136.23 +- 2.56 2 0 1 0 0.12 +- 0.19 2 15

PF14592 (2/2) Chondroitinase B
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13378 (2/2) Enolase C-terminal domain-like
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07729 (2/2) FCD domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01120 (2/2) Alpha-L-fucosidase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_5848 689.30 +- 494.85 4 0 4 4 0.06 +- 0.18 4 3

PF05147 (4/4) Lanthionine synthetase C-like protein
PF00069 (4/4) Protein kinase domain
PF04055 (3/4) Radical SAM superfamily
precursor_groups_5339 115.24 +- 34.84 5 0 0 0 0.07 +- 0.07 5 8

TIGR01484 (5/5) HAD hydrolase, family IIB
PF13309 (5/5) HTH domain
PF08348 (5/5) YheO-like PAS domain
PF08282 (5/5) haloacid dehalogenase-like hydrolase
PF04655 (5/5) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04075 (5/5) F420H(2)-dependent quinone reductase
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
precursor_groups_2821 311.63 +- 162.30 6 0 0 0 0.02 +- 0.03 6 2

PF06737 (6/6) Transglycosylase-like domain
PF01476 (6/6) LysM domain
precursor_groups_46044 35.25 +- 5.48 2 0 0 0 0.06 +- 0.06 2 4

PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_32179 128.07 +- 50.53 3 0 3 3 0.13 +- 0.13 3 12

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF03704 (3/3) Bacterial transcriptional activator domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (3/3) ABC-2 type transporter
PF00931 (3/3) NB-ARC domain
PF00881 (3/3) Nitroreductase family
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
precursor_groups_33170 177.11 +- 82.89 2 0 2 0 0.09 +- 0.13 2 13

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_50001 580.50 +- 0.00 2 0 0 0 0.02 +- 0.00 2 4

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04909 (2/2) Amidohydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_50007 40.06 +- 1.82 2 0 1 0 0.13 +- 0.06 2 14

TIGR01375 (2/2) sarcosine oxidase, gamma subunit family
TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_21294 234.03 +- 30.26 5 0 5 5 0.01 +- 0.00 5 7

TIGR03975 (5/5) ribosomal peptide maturation radical SAM protein 1
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF08241 (4/5) Methyltransferase domain
PF13424 (3/5) Tetratricopeptide repeat
PF03704 (3/5) Bacterial transcriptional activator domain
PF00931 (3/5) NB-ARC domain
precursor_groups_83142 39.09 +- 3.91 2 0 0 0 0.08 +- 0.01 2 5

PF16884 (2/2) N-terminal domain of oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_59518 540.00 +- 110.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
PF13649 (2/2) Methyltransferase domain
PF01380 (2/2) SIS domain
PF01263 (2/2) Aldose 1-epimerase
PF00550 (2/2) Phosphopantetheine attachment site
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
precursor_groups_37483 147.65 +- 42.12 3 0 0 0 0.03 +- 0.03 3 8

PF16951 (3/3) Putative methionine and alanine importer, small subunit
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
PF00209 (3/3) Sodium:neurotransmitter symporter family
TIGR00842 (2/3) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02028 (2/3) BCCT, betaine/carnitine/choline family transporter
PF00085 (2/3) Thioredoxin
precursor_groups_78427 86.61 +- 19.01 2 0 2 0 0.17 +- 0.27 2 22

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02222 (2/2) ATP-grasp domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_21277 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_groups_53291 32.16 +- 19.16 2 0 0 0 0.14 +- 0.29 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_groups_35685 105.30 +- 22.13 3 0 0 0 0.06 +- 0.02 3 4

PF03466 (3/3) LysR substrate binding domain
PF01979 (3/3) Amidohydrolase family
PF00756 (3/3) Putative esterase
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_35684 142.79 +- 50.71 3 0 0 0 0.14 +- 0.14 3 6

PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF01337 (3/3) Barstar (barnase inhibitor)
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_groups_60891 723.18 +- 136.82 2 0 2 0 0.01 +- 0.01 2 20

TIGR02814 (2/2) PfaD family protein
PF18328 (2/2) Fatty acid synthase subunit PfaD N-terminal domain
PF14765 (2/2) Polyketide synthase dehydratase
PF12833 (2/2) Helix-turn-helix domain
PF08659 (2/2) KR domain
PF07977 (2/2) FabA-like domain
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02311 (2/2) AraC-like ligand binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR02813 (1/2) polyketide-type polyunsaturated fatty acid synthase PfaA
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
precursor_groups_17678 121.57 +- 18.59 3 0 0 0 0.02 +- 0.01 3 5

TIGR00180 (3/3) ParB/RepB/Spo0J family partition protein
PF13614 (3/3) AAA domain
PF03417 (3/3) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02195 (3/3) ParB-like nuclease domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_groups_2226 40.92 +- 38.99 4 0 0 0 0.18 +- 0.22 4 10

PF12728 (4/4) Helix-turn-helix domain
PF10935 (4/4) Protein of unknown function (DUF2637)
PF05122 (4/4) Mobile element transfer protein
PF01580 (4/4) FtsK/SpoIIIE family
PF00589 (4/4) Phage integrase family
PF07690 (3/4) Major Facilitator Superfamily
PF00440 (3/4) Bacterial regulatory proteins, tetR family
PF13185 (2/4) GAF domain
PF08448 (2/4) PAS fold
PF07228 (2/4) Stage II sporulation protein E (SpoIIE)
precursor_groups_21070 95.84 +- 32.40 4 0 0 0 0.09 +- 0.16 4 15

PF03098 (4/4) Animal haem peroxidase
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01565 (4/4) FAD binding domain
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00067 (4/4) Cytochrome P450
TIGR01297 (3/4) cation diffusion facilitator family transporter
TIGR01048 (3/4) diaminopimelate decarboxylase
PF16916 (3/4) Dimerisation domain of Zinc Transporter
PF02784 (3/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01764 (3/4) Lipase (class 3)
PF01545 (3/4) Cation efflux family
PF01494 (3/4) FAD binding domain
PF08241 (2/4) Methyltransferase domain
precursor_groups_21077 1036.41 +- 903.21 4 0 4 0 0.06 +- 0.21 4 24

TIGR03297 (4/4) phosphonopyruvate decarboxylase
TIGR02315 (4/4) phosphonate ABC transporter, ATP-binding protein
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR01098 (4/4) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (4/4) phosphonate ABC transporter, permease protein PhnE
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF12974 (4/4) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01676 (4/4) Metalloenzyme superfamily
PF00698 (4/4) Acyl transferase domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (4/4) Glutamine amidotransferase class-I
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00106 (4/4) short chain dehydrogenase
PF00005 (4/4) ABC transporter
PF00550 (3/4) Phosphopantetheine attachment site
precursor_groups_21074 22.72 +- 3.64 3 0 0 0 0.09 +- 0.08 3 4

PF12840 (3/3) Helix-turn-helix domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF04616 (3/3) Glycosyl hydrolases family 43
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_groups_73955 93.82 +- 0.00 2 0 2 0 0.09 +- 0.04 2 12

TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (2/2) Amino acid kinase family
PF00682 (2/2) HMGL-like
PF00501 (2/2) AMP-binding enzyme
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_groups_66678 965.25 +- 464.75 2 0 0 0 0.01 +- 0.02 2 8

PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
precursor_groups_36305 449.33 +- 47.14 3 0 0 0 0.01 +- 0.00 3 6

PF17939 (3/3) Tetracyclin repressor-like, C-terminal domain
PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07859 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_475 66.06 +- 37.25 9 0 0 0 0.06 +- 0.06 9 5

PF13563 (9/9) 2'-5' RNA ligase superfamily
PF07690 (9/9) Major Facilitator Superfamily
PF06831 (9/9) Formamidopyrimidine-DNA glycosylase H2TH domain
PF01243 (9/9) Pyridoxamine 5'-phosphate oxidase
PF01149 (9/9) Formamidopyrimidine-DNA glycosylase N-terminal domain
precursor_groups_477 98.19 +- 78.90 4 0 0 0 0.07 +- 0.17 4 13

PF13458 (4/4) Periplasmic binding protein
PF13443 (4/4) Cro/C1-type HTH DNA-binding domain
PF11188 (4/4) Protein of unknown function (DUF2975)
PF01494 (4/4) FAD binding domain
PF01474 (4/4) Class-II DAHP synthetase family
TIGR00034 (3/4) 3-deoxy-7-phosphoheptulonate synthase
PF13193 (3/4) AMP-binding enzyme C-terminal domain
PF07732 (3/4) Multicopper oxidase
PF07731 (3/4) Multicopper oxidase
PF00793 (3/4) DAHP synthetase I family
PF00501 (3/4) AMP-binding enzyme
PF13191 (2/4) AAA ATPase domain
PF00196 (2/4) Bacterial regulatory proteins, luxR family
precursor_groups_50713 873.00 +- 288.00 2 0 0 0 0.01 +- 0.00 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13382 (2/2) Adenine deaminase C-terminal domain
PF08402 (2/2) TOBE domain
PF01979 (2/2) Amidohydrolase family
PF01156 (2/2) Inosine-uridine preferring nucleoside hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_473 138.21 +- 87.51 3 0 3 3 0.12 +- 0.24 3 12

TIGR04188 (3/3) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (3/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (3/3) putative ATP-grasp target RiPP
PF14408 (3/3) Ribosomally synthesised peptide in actinomycetes
PF13581 (3/3) Histidine kinase-like ATPase domain
PF07969 (3/3) Amidohydrolase family
PF07702 (3/3) UTRA domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01032 (3/3) FecCD transport family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
precursor_groups_478 60.38 +- 38.60 43 0 3 43 0.07 +- 0.05 43 4

PF13575 (43/43) Domain of unknown function (DUF4135)
PF08007 (43/43) Cupin superfamily protein
PF05147 (43/43) Lanthionine synthetase C-like protein
PF06189 (40/43) 5'-nucleotidase
precursor_groups_36308 1276.00 +- 925.97 3 0 3 3 0.01 +- 0.01 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF05139 (3/3) Erythromycin esterase
PF00733 (3/3) Asparagine synthase
precursor_groups_276 140.37 +- 160.76 6 0 1 0 0.08 +- 0.16 6 2

PF13193 (3/6) AMP-binding enzyme C-terminal domain
PF00501 (3/6) AMP-binding enzyme
precursor_groups_277 155.59 +- 91.77 3 0 1 0 0.13 +- 0.18 3

No common domains found
precursor_groups_274 433.99 +- 447.56 7 0 0 0 0.06 +- 0.09 7

No common domains found
precursor_groups_47791 404.62 +- 121.82 3 0 0 0 0.05 +- 0.02 3 13

PF16353 (3/3) Domain of unknown function(DUF4981)
PF07748 (3/3) Glycosyl hydrolases family 38 C-terminal domain
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01381 (3/3) Helix-turn-helix
PF01212 (3/3) Beta-eliminating lyase
PF01074 (3/3) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF04341 (2/3) Protein of unknown function, DUF485
PF00474 (2/3) Sodium:solute symporter family
precursor_groups_273 193.79 +- 163.78 5 0 0 2 0.11 +- 0.17 5 2

PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00005 (3/5) ABC transporter
precursor_groups_38837 134.45 +- 23.20 3 0 3 0 0.08 +- 0.11 3 12

TIGR04498 (3/3) abortive infection protein, AbiV family
PF18728 (3/3) AbiV
PF03711 (3/3) Orn/Lys/Arg decarboxylase, C-terminal domain
PF03709 (3/3) Orn/Lys/Arg decarboxylase, N-terminal domain
PF02371 (3/3) Transposase IS116/IS110/IS902 family
PF01609 (3/3) Transposase DDE domain
PF01548 (3/3) Transposase
PF01276 (3/3) Orn/Lys/Arg decarboxylase, major domain
PF00494 (3/3) Squalene/phytoene synthase
PF00348 (3/3) Polyprenyl synthetase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
precursor_groups_271 68.38 +- 79.34 36 0 4 2 0.12 +- 0.19 36 3

PF14019 (36/36) Protein of unknown function (DUF4235)
PF12277 (31/36) Protein of unknown function (DUF3618)
PF07332 (31/36) Putative Actinobacterial Holin-X, holin superfamily III
precursor_groups_37153 26.42 +- 6.75 2 0 0 0 0.12 +- 0.10 2 4

PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_48852 2680.76 +- 157.24 2 0 2 0 0.01 +- 0.00 2 16

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10067 (2/2) Predicted membrane protein (DUF2306)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01757 (2/2) Acyltransferase family
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00144 (2/2) Beta-lactamase
precursor_groups_13748 100.26 +- 53.04 6 0 6 0 0.07 +- 0.04 6 11

TIGR01733 (6/6) amino acid adenylation domain
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00698 (6/6) Acyl transferase domain
PF00668 (6/6) Condensation domain
PF00551 (6/6) Formyl transferase
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00067 (6/6) Cytochrome P450
precursor_groups_48856 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
precursor_groups_279 60.98 +- 40.78 26 0 0 0 0.18 +- 0.22 26 9

PF00296 (26/26) Luciferase-like monooxygenase
TIGR03860 (24/26) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07920 (24/26) Protein of unknown function (DUF1684)
PF13454 (23/26) FAD-NAD(P)-binding
PF02983 (22/26) Alpha-lytic protease prodomain
PF00089 (22/26) Trypsin
TIGR01726 (16/26) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (15/26) Binding-protein-dependent transport system inner membrane component
PF00005 (15/26) ABC transporter
precursor_groups_84202 337.77 +- 33.50 2 0 2 0 0.21 +- 0.29 2 29

TIGR02246 (2/2) conserved hypothetical protein
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF12051 (2/2) Protein of unknown function (DUF3533)
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/2) Histidine kinase
PF04673 (2/2) Polyketide synthesis cyclase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00483 (2/2) Nucleotidyl transferase
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
precursor_groups_2314 2928.34 +- 1803.37 5 0 4 1 0.01 +- 0.01 5 7

PF13649 (5/5) Methyltransferase domain
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00296 (5/5) Luciferase-like monooxygenase
PF00202 (5/5) Aminotransferase class-III
PF00005 (5/5) ABC transporter
PF00069 (4/5) Protein kinase domain
PF14588 (3/5) YjgF/chorismate_mutase-like, putative endoribonuclease
precursor_groups_19691 47.14 +- 1.98 4 0 0 4 0.10 +- 0.08 4 5

PF13360 (4/4) PQQ-like domain
PF00069 (4/4) Protein kinase domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
PF04185 (3/4) Phosphoesterase family
precursor_groups_2316 404.59 +- 369.41 2 0 1 1 0.11 +- 0.28 2 11

PF12811 (2/2) Bax inhibitor 1 like
TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07479 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF04055 (1/2) Radical SAM superfamily
PF01210 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_2317 237.15 +- 129.48 2 0 2 0 0.06 +- 0.19 2 22

PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR00977 (1/2) citramalate synthase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13459 (1/2) 4Fe-4S single cluster domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08502 (1/2) LeuA allosteric (dimerisation) domain
PF08031 (1/2) Berberine and berberine like
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01039 (1/2) Carboxyl transferase domain
PF00698 (1/2) Acyl transferase domain
PF00682 (1/2) HMGL-like
PF00668 (1/2) Condensation domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00067 (1/2) Cytochrome P450
precursor_groups_2318 520.00 +- 260.00 2 0 0 1 0.01 +- 0.00 2 6

PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08007 (1/2) Cupin superfamily protein
PF04055 (1/2) Radical SAM superfamily
PF01636 (1/2) Phosphotransferase enzyme family
PF00293 (1/2) NUDIX domain
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_65183 256.55 +- 33.70 2 0 0 0 0.02 +- 0.03 2 6

TIGR00212 (2/2) hydroxymethylbilane synthase
PF03900 (2/2) Porphobilinogen deaminase, C-terminal domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01379 (2/2) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_47227 401.61 +- 29.35 3 0 3 0 0.02 +- 0.01 3 11

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF03795 (3/3) YCII-related domain
PF02310 (3/3) B12 binding domain
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_25192 10.58 +- 0.26 2 0 0 0 0.19 +- 0.25 2 3

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
precursor_groups_28251 1513.29 +- 1279.53 4 0 1 0 0.02 +- 0.02 4 14

TIGR00217 (4/4) 4-alpha-glucanotransferase
PF13692 (4/4) Glycosyl transferases group 1
PF08323 (4/4) Starch synthase catalytic domain
PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF07883 (4/4) Cupin domain
PF06182 (4/4) ABC-2 family transporter protein
PF04321 (4/4) RmlD substrate binding domain
PF02446 (4/4) 4-alpha-glucanotransferase
PF01761 (4/4) 3-dehydroquinate synthase
PF00483 (4/4) Nucleotidyl transferase
PF00480 (4/4) ROK family
PF00202 (4/4) Aminotransferase class-III
PF00005 (4/4) ABC transporter
PF01636 (3/4) Phosphotransferase enzyme family
precursor_groups_18508 157.91 +- 24.09 2 0 0 0 0.03 +- 0.03 2 12

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14016 (2/2) Protein of unknown function (DUF4232)
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00775 (2/2) Dioxygenase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_35331 101.18 +- 78.70 3 0 0 0 0.10 +- 0.10 3 7

TIGR01428 (3/3) haloacid dehalogenase, type II
PF12973 (3/3) ChrR Cupin-like domain
PF07876 (3/3) Stress responsive A/B Barrel Domain
PF07690 (3/3) Major Facilitator Superfamily
PF01909 (3/3) Nucleotidyltransferase domain
PF00144 (3/3) Beta-lactamase
PF00702 (2/3) haloacid dehalogenase-like hydrolase
precursor_groups_27158 327.62 +- 23.17 3 0 0 0 0.01 +- 0.00 3 5

PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF07366 (3/3) SnoaL-like polyketide cyclase
PF05223 (3/3) NTF2-like N-terminal transpeptidase domain
PF00905 (3/3) Penicillin binding protein transpeptidase domain
precursor_groups_18504 1015.29 +- 590.98 5 0 0 0 0.01 +- 0.01 5 5

PF08666 (5/5) SAF domain
PF07811 (5/5) TadE-like protein
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF01476 (4/5) LysM domain
precursor_groups_56880 16.02 +- 0.10 2 0 0 0 0.12 +- 0.08 2 4

TIGR01695 (2/2) murein biosynthesis integral membrane protein MurJ
PF03023 (2/2) Lipid II flippase MurJ
PF01810 (2/2) LysE type translocator
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_58642 238.98 +- 117.11 2 0 1 0 0.05 +- 0.04 2 10

PF17387 (2/2) Glycosyl hydrolase family 59 central domain
PF13407 (2/2) Periplasmic binding protein domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02057 (2/2) Glycosyl hydrolase family 59
PF00703 (2/2) Glycosyl hydrolases family 2
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
PF03466 (1/2) LysR substrate binding domain
precursor_groups_79383 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 8

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_56888 6609.65 +- 614.35 2 0 0 0 0.01 +- 0.00 2 11

PF17914 (2/2) HopA1 effector protein family
PF13732 (2/2) Domain of unknown function (DUF4162)
PF12698 (2/2) ABC-2 family transporter protein
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00891 (2/2) O-methyltransferase domain
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_54476 20.95 +- 1.83 2 0 0 0 0.19 +- 0.38 2 8

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
TIGR01341 (2/2) aconitate hydratase 1
PF00704 (2/2) Glycosyl hydrolases family 18
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)
TIGR03851 (1/2) carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_groups_79389 14.41 +- 0.48 2 0 2 0 0.14 +- 0.01 2 4

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02633 (2/2) Creatinine amidohydrolase
PF01042 (2/2) Endoribonuclease L-PSP
precursor_groups_64647 9.44 +- 0.47 2 0 0 0 0.21 +- 0.25 2 6

PF13599 (2/2) Pentapeptide repeats (9 copies)
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF04185 (2/2) Phosphoesterase family
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
TIGR03396 (1/2) phospholipase C, phosphocholine-specific
PF05506 (1/2) Domain of unknown function (DUF756)
precursor_groups_25605 89.79 +- 16.34 2 0 0 0 0.18 +- 0.11 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_5445 41.42 +- 16.41 9 0 0 0 0.12 +- 0.24 9 5

PF03450 (9/9) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (9/9) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (9/9) [2Fe-2S] binding domain
PF01315 (9/9) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (9/9) FAD binding domain in molybdopterin dehydrogenase
precursor_groups_52749 1354.09 +- 64.09 2 0 0 0 0.01 +- 0.00 2 10

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF14832 (2/2) Putative oxalocrotonate tautomerase enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF00892 (2/2) EamA-like transporter family
PF00857 (2/2) Isochorismatase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_24738 98.67 +- 16.10 3 0 0 0 0.18 +- 0.28 3 11

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/3) AAA domain
PF07811 (3/3) TadE-like protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
PF07730 (2/3) Histidine kinase
PF00691 (2/3) OmpA family
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
precursor_groups_906 264.39 +- 292.10 3 0 1 3 0.03 +- 0.08 3 9

TIGR04269 (3/3) radical SAM/SPASM domain protein, FxsB family
PF13676 (3/3) TIR domain
PF13424 (3/3) Tetratricopeptide repeat
PF13374 (3/3) Tetratricopeptide repeat
PF04055 (3/3) Radical SAM superfamily
TIGR04268 (2/3) FXSXX-COOH protein
TIGR04267 (2/3) HEXXH motif domain
PF13365 (2/3) Trypsin-like peptidase domain
PF07728 (2/3) AAA domain (dynein-related subfamily)
precursor_groups_12161 295.05 +- 123.18 5 0 4 0 0.02 +- 0.06 5 5

TIGR01426 (5/5) glycosyltransferase, MGT family
PF02441 (5/5) Flavoprotein
PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00201 (5/5) UDP-glucoronosyl and UDP-glucosyl transferase
PF03559 (3/5) NDP-hexose 2,3-dehydratase
precursor_groups_611 104.67 +- 76.82 2 0 2 0 0.11 +- 0.22 2 27

PF03966 (2/2) Trm112p-like protein
TIGR00924 (1/2) amino acid/peptide transporter (Peptide:H+ symporter)
TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (1/2) aminodeoxychorismate synthase, component I
PF16864 (1/2) Dimerisation domain
PF13671 (1/2) AAA domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13439 (1/2) Glycosyltransferase Family 4
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF11847 (1/2) Alpha-(1->3)-arabinofuranosyltransferase
PF11271 (1/2) Porin PorA
PF08241 (1/2) Methyltransferase domain
PF05653 (1/2) Magnesium transporter NIPA
PF05199 (1/2) GMC oxidoreductase
PF04715 (1/2) Anthranilate synthase component I, N terminal region
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00891 (1/2) O-methyltransferase domain
PF00854 (1/2) POT family
PF00698 (1/2) Acyl transferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00535 (1/2) Glycosyl transferase family 2
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00425 (1/2) chorismate binding enzyme
PF00117 (1/2) Glutamine amidotransferase class-I
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_85390 603.67 +- 170.33 2 0 0 2 0.01 +- 0.00 2 5

PF13847 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
precursor_groups_71380 35.83 +- 7.17 2 0 0 0 0.06 +- 0.05 2 3

PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_13344 106.59 +- 14.82 2 0 0 0 0.08 +- 0.07 2 8

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF13602 (2/2) Zinc-binding dehydrogenase
PF08281 (2/2) Sigma-70, region 4
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04542 (2/2) Sigma-70 region 2
PF01425 (2/2) Amidase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_68154 408.72 +- 371.28 2 0 2 0 0.08 +- 0.24 2 9

TIGR02262 (2/2) benzoate-CoA ligase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08031 (2/2) Berberine and berberine like
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_56404 209.75 +- 177.25 2 0 2 0 0.05 +- 0.04 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_83967 603.67 +- 170.33 2 0 0 2 0.01 +- 0.00 2 5

PF13847 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
precursor_groups_70396 37.25 +- 3.10 2 0 2 0 0.08 +- 0.01 2 3

PF00550 (2/2) Phosphopantetheine attachment site
PF00268 (2/2) Ribonucleotide reductase, small chain
PF00067 (2/2) Cytochrome P450
precursor_groups_53438 153.97 +- 23.06 2 0 2 0 0.09 +- 0.08 2 14

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13489 (2/2) Methyltransferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF08659 (2/2) KR domain
PF07859 (2/2) alpha/beta hydrolase fold
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_19875 38.89 +- 9.46 4 0 0 0 0.08 +- 0.09 4 6

TIGR03696 (4/4) RHS repeat-associated core domain
TIGR01643 (4/4) YD repeat (two copies)
TIGR00778 (4/4) alkylhydroperoxidase AhpD family core domain
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF05593 (4/4) RHS Repeat
PF02627 (4/4) Carboxymuconolactone decarboxylase family
precursor_groups_38124 572.95 +- 56.52 3 0 2 2 0.01 +- 0.01 3 4

TIGR03882 (2/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
TIGR03604 (2/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (2/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_19870 62.04 +- 7.30 2 0 0 0 0.07 +- 0.07 2 4

PF13411 (2/2) MerR HTH family regulatory protein
PF01425 (2/2) Amidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00069 (2/2) Protein kinase domain
precursor_groups_55996 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 6

PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF02310 (2/2) B12 binding domain
PF01613 (2/2) Flavin reductase like domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_12456 61.84 +- 50.92 8 0 8 0 0.07 +- 0.04 8 3

PF00550 (8/8) Phosphopantetheine attachment site
PF00268 (8/8) Ribonucleotide reductase, small chain
PF00067 (8/8) Cytochrome P450
precursor_groups_38944 125.03 +- 36.02 3 0 3 0 0.14 +- 0.30 3 21

TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF14765 (2/3) Polyketide synthase dehydratase
PF08990 (2/3) Erythronolide synthase docking
PF08659 (2/3) KR domain
PF08044 (2/3) Domain of unknown function (DUF1707)
precursor_groups_30481 130.03 +- 70.54 2 0 0 0 0.14 +- 0.09 2 5

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF06259 (2/2) Alpha/beta hydrolase
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_71548 880.52 +- 76.75 2 0 2 0 0.01 +- 0.00 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_4827 104.33 +- 24.67 2 0 0 0 0.17 +- 0.20 2 11

PF07478 (2/2) D-ala D-ala ligase C-terminus
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF00583 (2/2) Acetyltransferase (GNAT) family
TIGR02605 (1/2) putative regulatory protein, FmdB family
PF14325 (1/2) Domain of unknown function (DUF4383)
PF13378 (1/2) Enolase C-terminal domain-like
PF09723 (1/2) Zinc ribbon domain
PF07729 (1/2) FCD domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
precursor_groups_40836 144.15 +- 36.04 2 0 0 0 0.06 +- 0.04 2 9

PF13671 (2/2) AAA domain
PF13649 (2/2) Methyltransferase domain
PF09364 (2/2) XFP N-terminal domain
PF09363 (2/2) XFP C-terminal domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (2/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01427 (2/2) D-ala-D-ala dipeptidase
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_2001 19.78 +- 1.72 2 0 1 0 0.15 +- 0.21 2 4

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00293 (1/2) NUDIX domain
precursor_groups_40834 115.75 +- 50.85 2 0 2 0 0.17 +- 0.24 2 14

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF17137 (2/2) Domain of unknown function (DUF5110)
PF13802 (2/2) Galactose mutarotase-like
PF13437 (2/2) HlyD family secretion protein
PF03412 (2/2) Peptidase C39 family
PF01055 (2/2) Glycosyl hydrolases family 31
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13424 (1/2) Tetratricopeptide repeat
PF13374 (1/2) Tetratricopeptide repeat
PF13365 (1/2) Trypsin-like peptidase domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF00501 (1/2) AMP-binding enzyme
precursor_groups_74093 174.15 +- 19.35 2 0 2 0 0.02 +- 0.01 2 6

TIGR03026 (2/2) nucleotide sugar dehydrogenase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_61850 8.51 +- 0.39 2 0 1 0 0.23 +- 0.20 2 5

PF13569 (2/2) Domain of unknown function (DUF4132)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00155 (2/2) Aminotransferase class I and II
PF05762 (1/2) VWA domain containing CoxE-like protein
PF00392 (1/2) Bacterial regulatory proteins, gntR family
precursor_groups_82811 25.37 +- 8.92 2 0 1 0 0.13 +- 0.26 2 9

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF13377 (2/2) Periplasmic binding protein-like domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04314 (2/2) Copper chaperone PCu(A)C
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00155 (2/2) Aminotransferase class I and II
PF00122 (2/2) E1-E2 ATPase
precursor_groups_1261 60.12 +- 4.83 2 0 0 0 0.10 +- 0.11 2 12

TIGR01525 (1/2) heavy metal translocating P-type ATPase
PF08751 (1/2) TrwC relaxase
PF08007 (1/2) Cupin superfamily protein
PF07371 (1/2) Protein of unknown function (DUF1490)
PF04672 (1/2) S-adenosyl methyltransferase
PF01297 (1/2) Zinc-uptake complex component A periplasmic
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00950 (1/2) ABC 3 transport family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00248 (1/2) Aldo/keto reductase family
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter
precursor_groups_75650 305.00 +- 215.00 2 0 0 0 0.02 +- 0.01 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00171 (2/2) Aldehyde dehydrogenase family
PF08031 (1/2) Berberine and berberine like
PF01565 (1/2) FAD binding domain
precursor_groups_249 17.26 +- 5.07 2 0 0 0 0.21 +- 0.28 2 12

PF11387 (2/2) Protein of unknown function (DUF2795)
TIGR02891 (1/2) cytochrome c oxidase, subunit I
PF16861 (1/2) Carbamoyltransferase C-terminus
PF14907 (1/2) Uncharacterised nucleotidyltransferase
PF12270 (1/2) Cytochrome c oxidase subunit IV
PF02543 (1/2) Carbamoyltransferase N-terminus
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00384 (1/2) Molybdopterin oxidoreductase
PF00149 (1/2) Calcineurin-like phosphoesterase
PF00115 (1/2) Cytochrome C and Quinol oxidase polypeptide I
PF00106 (1/2) short chain dehydrogenase
precursor_groups_38301 296.41 +- 256.09 2 0 0 0 0.18 +- 0.09 2 13

PF13377 (2/2) Periplasmic binding protein-like domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00135 (2/2) Carboxylesterase family
PF14310 (1/2) Fibronectin type III-like domain
PF09084 (1/2) NMT1/THI5 like
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
precursor_groups_83812 98.26 +- 57.40 2 0 0 0 0.10 +- 0.07 2 13

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13202 (2/2) EF hand
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF13411 (1/2) MerR HTH family regulatory protein
PF01370 (1/2) NAD dependent epimerase/dehydratase family
precursor_groups_73572 5109.05 +- 2040.95 2 0 2 2 0.01 +- 0.01 2 9

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF12698 (2/2) ABC-2 family transporter protein
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_groups_18656 12.90 +- 0.99 5 0 0 0 0.23 +- 0.04 5 5

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF04909 (5/5) Amidohydrolase
PF01575 (5/5) MaoC like domain
PF00501 (5/5) AMP-binding enzyme
precursor_groups_6781 14.17 +- 3.10 4 0 0 0 0.14 +- 0.10 4 2

PF07995 (4/4) Glucose / Sorbosone dehydrogenase
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
precursor_groups_43965 136.90 +- 130.86 3 0 2 0 0.03 +- 0.03 3 3

PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF13560 (2/3) Helix-turn-helix domain
PF00106 (2/3) short chain dehydrogenase
precursor_groups_2930 39.48 +- 9.71 2 0 0 0 0.09 +- 0.12 2 8

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05593 (2/2) RHS Repeat
PF00668 (2/2) Condensation domain
PF15657 (1/2) HNH/Endo VII superfamily nuclease toxins
PF07179 (1/2) SseB protein N-terminal domain
precursor_groups_42494 237.30 +- 29.18 3 0 3 0 0.01 +- 0.00 3 6

TIGR01926 (3/3) uncharacterized peroxidase-related enzyme
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF07690 (3/3) Major Facilitator Superfamily
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00106 (3/3) short chain dehydrogenase
precursor_groups_1662 708.41 +- 344.45 35 20 15 35 0.02 +- 0.06 15 7

TIGR03891 (35/35) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (35/35) Lantibiotic biosynthesis dehydratase C-term
PF05147 (35/35) Lanthionine synthetase C-like protein
PF04738 (35/35) Lantibiotic dehydratase, N terminus
PF00005 (35/35) ABC transporter
TIGR03731 (34/35) lantibiotic, gallidermin/nisin family
PF02052 (29/35) Gallidermin
precursor_groups_17881 181.70 +- 78.30 2 0 0 0 0.04 +- 0.05 2 9

PF14552 (2/2) Tautomerase enzyme
PF13546 (2/2) DDE superfamily endonuclease
PF12706 (2/2) Beta-lactamase superfamily domain
PF07859 (2/2) alpha/beta hydrolase fold
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01361 (2/2) Tautomerase enzyme
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_17885 148.05 +- 46.29 4 0 0 4 0.14 +- 0.10 4 8

TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
precursor_groups_1997 480.08 +- 238.08 3 0 0 0 0.07 +- 0.14 3 11

TIGR01426 (3/3) glycosyltransferase, MGT family
PF13546 (3/3) DDE superfamily endonuclease
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (3/3) Pretoxin HINT domain
PF04471 (3/3) Restriction endonuclease
PF03752 (3/3) Short repeats of unknown function
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF00535 (3/3) Glycosyl transferase family 2
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00089 (3/3) Trypsin
PF00082 (3/3) Subtilase family
precursor_groups_60976 109.86 +- 0.00 2 0 0 0 0.09 +- 0.00 2 8

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00005 (2/2) ABC transporter
precursor_groups_22371 338.62 +- 48.38 2 0 0 0 0.01 +- 0.00 2 2

PF07690 (2/2) Major Facilitator Superfamily
PF07519 (2/2) Tannase and feruloyl esterase
precursor_groups_6306 257.74 +- 131.52 2 0 0 0 0.02 +- 0.10 2 15

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13560 (1/2) Helix-turn-helix domain
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF01580 (1/2) FtsK/SpoIIIE family
PF00436 (1/2) Single-strand binding protein family
precursor_groups_76754 17.37 +- 1.74 2 0 0 0 0.12 +- 0.08 2 2

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF04616 (2/2) Glycosyl hydrolases family 43
precursor_groups_29180 263.91 +- 86.58 4 0 4 0 0.02 +- 0.01 4 14

TIGR01733 (4/4) amino acid adenylation domain
PF18014 (4/4) Acetyltransferase (GNAT) domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF05199 (4/4) GMC oxidoreductase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00975 (4/4) Thioesterase domain
PF00732 (4/4) GMC oxidoreductase
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_71098 140.33 +- 50.33 2 0 2 0 0.07 +- 0.18 2 16

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF16864 (1/2) Dimerisation domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF03621 (1/2) MbtH-like protein
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01937 (1/2) Protein of unknown function DUF89
PF00975 (1/2) Thioesterase domain
PF00891 (1/2) O-methyltransferase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_18497 95.56 +- 0.00 2 0 0 0 0.04 +- 0.05 2 3

PF13560 (2/2) Helix-turn-helix domain
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_71092 417.11 +- 145.80 2 0 0 0 0.02 +- 0.02 2 5

PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF00857 (2/2) Isochorismatase family
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_39350 462.27 +- 130.14 3 0 0 0 0.01 +- 0.01 3 9

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF00487 (3/3) Fatty acid desaturase
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_22176 2193.23 +- 1659.28 5 0 5 5 0.04 +- 0.10 5 10

TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF04072 (5/5) Leucine carboxyl methyltransferase
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (5/5) CPBP intramembrane metalloprotease
PF01061 (5/5) ABC-2 type transporter
PF00881 (5/5) Nitroreductase family
PF00005 (5/5) ABC transporter
TIGR00027 (4/5) methyltransferase, TIGR00027 family
PF00149 (4/5) Calcineurin-like phosphoesterase
precursor_groups_71096 285.17 +- 3.72 2 0 0 0 0.03 +- 0.03 2 5

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF01425 (2/2) Amidase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13546 (1/2) DDE superfamily endonuclease
PF01526 (1/2) Tn3 transposase DDE domain
precursor_groups_6493 388.50 +- 1.50 2 0 0 2 0.01 +- 0.00 2 6

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
precursor_groups_60310 73.15 +- 4.85 2 0 0 0 0.04 +- 0.03 2 4

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_19855 204.73 +- 99.57 4 0 2 0 0.08 +- 0.07 4 22

TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08713 (4/4) DNA alkylation repair enzyme
PF08659 (4/4) KR domain
PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01494 (4/4) FAD binding domain
PF00975 (4/4) Thioesterase domain
PF00850 (4/4) Histone deacetylase domain
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (4/4) Acyl transferase domain
PF00551 (4/4) Formyl transferase
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00155 (4/4) Aminotransferase class I and II
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF18029 (2/4) Glyoxalase-like domain
PF07478 (2/4) D-ala D-ala ligase C-terminus
PF01820 (2/4) D-ala D-ala ligase N-terminus
precursor_groups_81551 18.08 +- 0.35 2 0 2 2 0.17 +- 0.33 2 6

PF17885 (2/2) Styrene monooxygenase A putative substrate binding domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00494 (2/2) Squalene/phytoene synthase
PF00069 (2/2) Protein kinase domain
precursor_groups_3469 106.71 +- 58.24 10 0 0 0 0.16 +- 0.29 10 11

TIGR03177 (10/10) Flp pilus assembly protein CpaB
PF16976 (10/10) Flp pilus assembly protein RcpC/CpaB
PF07811 (10/10) TadE-like protein
PF00482 (10/10) Type II secretion system (T2SS), protein F
PF00437 (10/10) Type II/IV secretion system protein
PF13614 (9/10) AAA domain
PF07730 (9/10) Histidine kinase
PF00691 (9/10) OmpA family
PF00196 (9/10) Bacterial regulatory proteins, luxR family
PF00072 (9/10) Response regulator receiver domain
PF13400 (5/10) Putative Flp pilus-assembly TadE/G-like
precursor_groups_6496 76.72 +- 70.53 4 0 0 0 0.13 +- 0.27 4 8

TIGR00236 (4/4) UDP-N-acetylglucosamine 2-epimerase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13517 (4/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08031 (4/4) Berberine and berberine like
PF07690 (4/4) Major Facilitator Superfamily
PF02350 (4/4) UDP-N-acetylglucosamine 2-epimerase
PF01757 (4/4) Acyltransferase family
PF01565 (4/4) FAD binding domain
precursor_groups_55173 18.14 +- 6.05 2 0 0 0 0.14 +- 0.07 2 4

PF14759 (2/2) Reductase C-terminal
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
precursor_groups_43893 110.74 +- 12.19 3 0 0 0 0.15 +- 0.17 3 9

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_groups_78762 13.16 +- 3.61 2 0 0 0 0.16 +- 0.29 2 5

TIGR03707 (2/2) polyphosphate kinase 2
PF12724 (2/2) Flavodoxin domain
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_27859 47.05 +- 11.67 3 0 0 0 0.20 +- 0.37 3 12

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (3/3) YD repeat (two copies)
TIGR00613 (3/3) DNA repair protein RecO
TIGR00055 (3/3) di-trans,poly-cis-decaprenylcistransferase
PF13560 (3/3) Helix-turn-helix domain
PF11967 (3/3) Recombination protein O N terminal
PF05593 (3/3) RHS Repeat
PF04149 (3/3) Domain of unknown function (DUF397)
PF02565 (3/3) Recombination protein O C terminal
PF01255 (3/3) Putative undecaprenyl diphosphate synthase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00106 (3/3) short chain dehydrogenase
precursor_groups_40492 61.45 +- 41.75 2 0 1 0 0.09 +- 0.12 2 9

PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13535 (1/2) ATP-grasp domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00293 (1/2) NUDIX domain
precursor_groups_32882 62.67 +- 11.94 2 0 0 0 0.10 +- 0.14 2 7

PF13751 (2/2) Transposase DDE domain
PF12704 (2/2) MacB-like periplasmic core domain
PF05598 (2/2) Transposase domain (DUF772)
PF02687 (2/2) FtsX-like permease family
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_6162 100.87 +- 71.79 8 0 0 0 0.21 +- 0.28 8 17

TIGR00105 (8/8) ribosomal protein bL31
PF01756 (8/8) Acyl-CoA oxidase
PF01497 (8/8) Periplasmic binding protein
PF01197 (8/8) Ribosomal protein L31
PF00583 (8/8) Acetyltransferase (GNAT) family
TIGR00765 (7/8) YihY family inner membrane protein
PF05922 (7/8) Peptidase inhibitor I9
PF03631 (7/8) Virulence factor BrkB
PF02770 (7/8) Acyl-CoA dehydrogenase, middle domain
PF00294 (7/8) pfkB family carbohydrate kinase
PF00082 (7/8) Subtilase family
PF11941 (6/8) Domain of unknown function (DUF3459)
PF07705 (6/8) CARDB
PF00754 (6/8) F5/8 type C domain
PF00128 (6/8) Alpha amylase, catalytic domain
PF01032 (4/8) FecCD transport family
PF00005 (4/8) ABC transporter
precursor_groups_86048 71.97 +- 1.42 2 0 0 0 0.14 +- 0.16 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_55375 28.46 +- 0.27 2 0 0 0 0.25 +- 0.31 2 13

TIGR02133 (2/2) ribose 5-phosphate isomerase
TIGR00232 (2/2) transketolase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00121 (2/2) Triosephosphate isomerase
precursor_groups_30856 361.00 +- 86.99 4 0 4 0 0.12 +- 0.25 4 33

TIGR01902 (4/4) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (4/4) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR00768 (4/4) alpha-L-glutamate ligase, RimK family
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF13602 (4/4) Zinc-binding dehydrogenase
PF13535 (4/4) ATP-grasp domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08990 (4/4) Erythronolide synthase docking
PF08659 (4/4) KR domain
PF08443 (4/4) RimK-like ATP-grasp domain
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02779 (4/4) Transketolase, pyrimidine binding domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (4/4) Thioesterase domain
PF00857 (4/4) Isochorismatase family
PF00698 (4/4) Acyl transferase domain
PF00696 (4/4) Amino acid kinase family
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_12900 486.75 +- 211.32 3 0 3 0 0.01 +- 0.01 3 4

PF11706 (3/3) CGNR zinc finger
PF01713 (3/3) Smr domain
PF01596 (3/3) O-methyltransferase
PF01494 (3/3) FAD binding domain
precursor_groups_244 108.10 +- 152.63 10 0 3 0 0.13 +- 0.26 10 3

PF00196 (7/10) Bacterial regulatory proteins, luxR family
PF07730 (5/10) Histidine kinase
PF00072 (5/10) Response regulator receiver domain
precursor_groups_23354 66.14 +- 7.57 2 0 2 0 0.18 +- 0.26 2 10

PF13560 (2/2) Helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07883 (2/2) Cupin domain
PF03466 (2/2) LysR substrate binding domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (2/2) ABC transporter
precursor_groups_6543 58.11 +- 27.96 2 0 2 2 0.17 +- 0.33 2 10

PF07730 (2/2) Histidine kinase
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03793 (2/2) PASTA domain
PF00664 (2/2) ABC transporter transmembrane region
PF00326 (2/2) Prolyl oligopeptidase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_13906 58.29 +- 19.11 2 0 0 2 0.17 +- 0.25 2 5

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01425 (2/2) Amidase
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_71362 169.53 +- 20.58 2 0 0 2 0.08 +- 0.14 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05726 (2/2) Pirin C-terminal cupin domain
PF04055 (2/2) Radical SAM superfamily
PF02678 (2/2) Pirin
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_1916 164.86 +- 47.86 2 0 0 0 0.04 +- 0.02 2 5

TIGR00784 (2/2) citrate transporter
PF18435 (2/2) Esterase Ig-like N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF03600 (2/2) Citrate transporter
PF00135 (2/2) Carboxylesterase family
precursor_groups_8275 99.95 +- 29.05 2 0 0 0 0.02 +- 0.02 2 5

PF17866 (2/2) AAA lid domain
PF13229 (2/2) Right handed beta helix region
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_26074 915.58 +- 610.36 3 0 3 0 0.09 +- 0.22 3 15

TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF04339 (3/3) Peptidogalycan biosysnthesis/recognition
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01061 (3/3) ABC-2 type transporter
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_12611 51.74 +- 22.21 7 0 0 0 0.16 +- 0.17 7 5

TIGR00996 (7/7) virulence factor Mce family protein
PF11887 (7/7) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (7/7) MlaD protein
PF02405 (7/7) Permease MlaE
PF00005 (7/7) ABC transporter
precursor_groups_7543 72.46 +- 24.45 3 0 3 0 0.14 +- 0.12 3 8

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13377 (3/3) Periplasmic binding protein-like domain
PF08220 (3/3) DeoR-like helix-turn-helix domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (3/3) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_7540 236.73 +- 79.23 5 0 0 0 0.08 +- 0.16 5 16

PF13649 (5/5) Methyltransferase domain
PF13394 (5/5) 4Fe-4S single cluster domain
PF10977 (5/5) Protein of unknown function (DUF2797)
PF05331 (5/5) Protein of unknown function (DUF742)
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02223 (5/5) Thymidylate kinase
PF01590 (5/5) GAF domain
PF01242 (5/5) 6-pyruvoyl tetrahydropterin synthase
PF01227 (5/5) GTP cyclohydrolase I
PF00723 (5/5) Glycosyl hydrolases family 15
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (5/5) NUDIX domain
precursor_groups_12340 41.66 +- 0.48 4 0 0 0 0.22 +- 0.14 4 8

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08533 (4/4) Beta-galactosidase C-terminal domain
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_groups_34009 431.52 +- 139.52 3 0 0 0 0.01 +- 0.01 3 9

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF07202 (3/3) T-complex protein 10 C-terminus
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
precursor_groups_59977 258.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_70373 320.94 +- 35.15 2 0 0 0 0.06 +- 0.05 2 9

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/2) Alpha galactosidase A
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF01120 (2/2) Alpha-L-fucosidase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_groups_43784 80.45 +- 41.36 3 0 2 0 0.16 +- 0.12 3 4

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF10091 (3/3) Putative glucoamylase
PF01229 (3/3) Glycosyl hydrolases family 39
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_31523 39.22 +- 0.31 3 0 0 0 0.23 +- 0.36 3 8

TIGR01891 (3/3) amidohydrolase
TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13649 (3/3) Methyltransferase domain
PF07687 (3/3) Peptidase dimerisation domain
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00005 (3/3) ABC transporter
precursor_groups_61212 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_groups_12582 283.77 +- 98.70 3 0 1 0 0.07 +- 0.11 3 7

PF05426 (3/3) Alginate lyase
PF05345 (3/3) Putative Ig domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00295 (3/3) Glycosyl hydrolases family 28
PF00135 (3/3) Carboxylesterase family
TIGR01409 (2/3) Tat (twin-arginine translocation) pathway signal sequence
PF01547 (2/3) Bacterial extracellular solute-binding protein
precursor_groups_3209 54.64 +- 39.23 11 0 1 0 0.10 +- 0.15 11 3

PF01292 (11/11) Prokaryotic cytochrome b561
PF00174 (11/11) Oxidoreductase molybdopterin binding domain
PF07519 (10/11) Tannase and feruloyl esterase
precursor_groups_4176 36.49 +- 24.16 18 0 1 0 0.10 +- 0.14 18 3

PF13649 (18/18) Methyltransferase domain
PF00484 (18/18) Carbonic anhydrase
PF00916 (13/18) Sulfate permease family
precursor_groups_95 64.95 +- 43.57 5 0 2 0 0.23 +- 0.20 5 9

PF14659 (5/5) Phage integrase, N-terminal SAM-like domain
PF12728 (5/5) Helix-turn-helix domain
PF10935 (5/5) Protein of unknown function (DUF2637)
PF05122 (5/5) Mobile element transfer protein
PF01580 (5/5) FtsK/SpoIIIE family
PF00589 (5/5) Phage integrase family
TIGR01764 (4/5) DNA binding domain, excisionase family
PF07702 (4/5) UTRA domain
PF00392 (4/5) Bacterial regulatory proteins, gntR family
precursor_groups_65372 55.98 +- 0.00 2 0 0 0 0.20 +- 0.37 2 13

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
TIGR00544 (2/2) prolipoprotein diacylglyceryl transferase
PF13462 (2/2) Thioredoxin
PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01988 (2/2) VIT family
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF01790 (2/2) Prolipoprotein diacylglyceryl transferase
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00067 (2/2) Cytochrome P450
precursor_groups_45810 84.88 +- 11.43 3 0 0 0 0.10 +- 0.07 3 8

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13564 (3/3) DoxX-like family
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_groups_37682 204.18 +- 77.53 3 0 0 0 0.01 +- 0.01 3 1

PF01833 (3/3) IPT/TIG domain
precursor_groups_41801 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_3207 44.57 +- 18.71 8 0 0 0 0.18 +- 0.19 8 8

TIGR03718 (8/8) integral membrane protein, TerC family
PF05331 (8/8) Protein of unknown function (DUF742)
PF03741 (8/8) Integral membrane protein TerC family
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF00378 (7/8) Enoyl-CoA hydratase/isomerase
PF00067 (7/8) Cytochrome P450
PF18029 (4/8) Glyoxalase-like domain
precursor_groups_58805 141.30 +- 118.70 2 0 0 0 0.05 +- 0.05 2 4

PF02018 (2/2) Carbohydrate binding domain
PF00756 (2/2) Putative esterase
PF00704 (2/2) Glycosyl hydrolases family 18
PF00041 (2/2) Fibronectin type III domain
precursor_groups_11838 485.44 +- 338.34 8 0 0 0 0.04 +- 0.08 8 6

TIGR03930 (8/8) WXG100 family type VII secretion target
PF06013 (8/8) Proteins of 100 residues with WXG
PF05108 (8/8) Type VII secretion system ESX-1, transport TM domain B
PF00082 (8/8) Subtilase family
TIGR03921 (7/8) type VII secretion-associated serine protease mycosin
TIGR03919 (5/8) type VII secretion protein EccB
precursor_groups_7943 42.96 +- 9.04 2 0 0 0 0.05 +- 0.04 2 3

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13783 (2/2) Domain of unknown function (DUF4177)
PF01120 (2/2) Alpha-L-fucosidase
precursor_groups_26695 468.39 +- 129.56 3 0 0 0 0.02 +- 0.01 3 7

TIGR02798 (3/3) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12697 (3/3) Alpha/beta hydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF03737 (3/3) Aldolase/RraA
PF02426 (3/3) Muconolactone delta-isomerase
PF02585 (2/3) GlcNAc-PI de-N-acetylase
precursor_groups_84190 53.33 +- 11.17 2 0 0 0 0.11 +- 0.16 2 15

PF14871 (2/2) Hypothetical glycosyl hydrolase 6
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13602 (2/2) Zinc-binding dehydrogenase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08448 (2/2) PAS fold
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00989 (2/2) PAS fold
PF00457 (2/2) Glycosyl hydrolases family 11
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF03664 (1/2) Glycosyl hydrolase family 62
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_groups_49475 16.73 +- 0.60 2 0 0 0 0.12 +- 0.03 2 3

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF04616 (2/2) Glycosyl hydrolases family 43
precursor_groups_11832 25.75 +- 12.88 2 0 0 0 0.16 +- 0.26 2 14

PF12728 (2/2) Helix-turn-helix domain
PF00589 (2/2) Phage integrase family
TIGR01764 (1/2) DNA binding domain, excisionase family
TIGR00589 (1/2) methylated-DNA--[protein]-cysteine S-methyltransferase
TIGR00254 (1/2) diguanylate cyclase (GGDEF) domain
PF17912 (1/2) MalK OB fold domain
PF13532 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13520 (1/2) Amino acid permease
PF04461 (1/2) Protein of unknown function (DUF520)
PF03459 (1/2) TOBE domain
PF02870 (1/2) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00990 (1/2) Diguanylate cyclase, GGDEF domain
PF00005 (1/2) ABC transporter
precursor_groups_11833 1269.58 +- 59.24 6 0 6 0 0.01 +- 0.00 6 8

TIGR01733 (6/6) amino acid adenylation domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF00975 (6/6) Thioesterase domain
PF00668 (6/6) Condensation domain
PF00561 (6/6) alpha/beta hydrolase fold
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00326 (6/6) Prolyl oligopeptidase family
precursor_groups_16827 103.82 +- 41.92 4 0 0 0 0.02 +- 0.02 4 2

PF07336 (4/4) Putative stress-induced transcription regulator
PF00069 (4/4) Protein kinase domain
precursor_groups_4896 140.60 +- 60.77 2 0 1 0 0.08 +- 0.14 2 14

PF17939 (1/2) Tetracyclin repressor-like, C-terminal domain
PF14759 (1/2) Reductase C-terminal
PF13649 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF13411 (1/2) MerR HTH family regulatory protein
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08044 (1/2) Domain of unknown function (DUF1707)
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF05050 (1/2) Methyltransferase FkbM domain
PF00501 (1/2) AMP-binding enzyme
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00072 (1/2) Response regulator receiver domain
PF00067 (1/2) Cytochrome P450
precursor_groups_34483 941.38 +- 0.00 2 0 0 0 0.03 +- 0.01 2 13

PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF02055 (2/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (2/2) IPT/TIG domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_11589 698.38 +- 267.94 8 0 0 8 0.01 +- 0.00 8 4

PF07690 (8/8) Major Facilitator Superfamily
PF04055 (8/8) Radical SAM superfamily
PF02441 (8/8) Flavoprotein
PF02310 (4/8) B12 binding domain
precursor_groups_69938 81.42 +- 18.09 2 0 2 0 0.12 +- 0.06 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13377 (2/2) Periplasmic binding protein-like domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_22209 574.95 +- 497.55 2 0 0 0 0.03 +- 0.04 2 15

TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF14310 (1/2) Fibronectin type III-like domain
PF13649 (1/2) Methyltransferase domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05729 (1/2) NACHT domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01872 (1/2) RibD C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00480 (1/2) ROK family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00005 (1/2) ABC transporter
precursor_groups_11233 1225.93 +- 2199.23 8 0 8 0 0.06 +- 0.22 8 13

PF17914 (8/8) HopA1 effector protein family
PF00296 (8/8) Luciferase-like monooxygenase
TIGR01099 (6/8) UTP--glucose-1-phosphate uridylyltransferase
PF13546 (6/8) DDE superfamily endonuclease
PF08240 (6/8) Alcohol dehydrogenase GroES-like domain
PF08028 (6/8) Acyl-CoA dehydrogenase, C-terminal domain
PF02195 (6/8) ParB-like nuclease domain
PF01613 (6/8) Flavin reductase like domain
PF00982 (6/8) Glycosyltransferase family 20
PF00483 (6/8) Nucleotidyl transferase
PF02894 (5/8) Oxidoreductase family, C-terminal alpha/beta domain
PF02771 (5/8) Acyl-CoA dehydrogenase, N-terminal domain
PF01636 (4/8) Phosphotransferase enzyme family
precursor_groups_16910 55.76 +- 2.01 2 0 2 0 0.16 +- 0.21 2 8

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF14310 (1/2) Fibronectin type III-like domain
PF09362 (1/2) Domain of unknown function (DUF1996)
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00754 (1/2) F5/8 type C domain
precursor_groups_59045 218.91 +- 125.09 2 0 0 0 0.03 +- 0.02 2 7

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_37118 4130.91 +- 755.96 3 0 0 0 0.01 +- 0.01 3 10

PF13814 (3/3) Replication-relaxation
PF13406 (3/3) Transglycosylase SLT domain
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF01476 (2/3) LysM domain
precursor_groups_34310 127.43 +- 19.00 3 0 0 3 0.13 +- 0.18 3 9

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF01494 (3/3) FAD binding domain
PF00881 (3/3) Nitroreductase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_20939 126.98 +- 47.10 3 0 1 0 0.06 +- 0.04 3 5

TIGR04538 (3/3) cytochrome P450, cyclodipeptide synthase-associated
PF09339 (3/3) IclR helix-turn-helix domain
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF01614 (3/3) Bacterial transcriptional regulator
PF00067 (3/3) Cytochrome P450
precursor_groups_60406 135.10 +- 124.90 2 0 0 0 0.10 +- 0.16 2 1

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_36386 23.31 +- 0.88 2 0 0 0 0.17 +- 0.09 2 2

PF11575 (2/2) FhuF 2Fe-2S C-terminal domain
PF01794 (2/2) Ferric reductase like transmembrane component
precursor_groups_6070 79.19 +- 52.54 9 0 0 0 0.17 +- 0.32 9 18

PF17863 (9/9) AAA lid domain
PF13519 (9/9) von Willebrand factor type A domain
PF13365 (9/9) Trypsin-like peptidase domain
PF07726 (9/9) ATPase family associated with various cellular activities (AAA)
PF07584 (9/9) Aerotolerance regulator N-terminal
PF02518 (9/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01882 (9/9) Protein of unknown function DUF58
PF00672 (9/9) HAMP domain
PF00512 (9/9) His Kinase A (phospho-acceptor) domain
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00072 (9/9) Response regulator receiver domain
TIGR00838 (8/9) argininosuccinate lyase
TIGR00785 (8/9) transporter, divalent anion:Na+ symporter (DASS) family
TIGR00032 (8/9) argininosuccinate synthase
PF14698 (8/9) Argininosuccinate lyase C-terminal
PF00939 (8/9) Sodium:sulfate symporter transmembrane region
PF00764 (8/9) Arginosuccinate synthase
PF00206 (8/9) Lyase
precursor_groups_53920 731.71 +- 592.69 2 0 2 0 0.06 +- 0.06 2 16

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10862 (2/2) FcoT-like thioesterase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_3510 28.06 +- 9.39 23 0 2 0 0.14 +- 0.06 23 4

TIGR03328 (23/23) methylthioribulose-1-phosphate dehydratase
TIGR01691 (23/23) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (23/23) ARD/ARD' family
PF00596 (23/23) Class II Aldolase and Adducin N-terminal domain
precursor_groups_3512 1001.02 +- 960.60 4 0 4 0 0.07 +- 0.21 4 11

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF00005 (4/4) ABC transporter
PF13450 (3/4) NAD(P)-binding Rossmann-like domain
PF12698 (2/4) ABC-2 family transporter protein
PF05719 (2/4) Golgi phosphoprotein 3 (GPP34)
PF02771 (2/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/4) Acyl-CoA dehydrogenase, middle domain
PF00664 (2/4) ABC transporter transmembrane region
PF00550 (2/4) Phosphopantetheine attachment site
PF00441 (2/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_70709 36.89 +- 13.11 2 0 0 0 0.09 +- 0.09 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_groups_4300 10.42 +- 1.63 8 0 8 0 0.20 +- 0.29 8 7

TIGR00589 (8/8) methylated-DNA--[protein]-cysteine S-methyltransferase
PF12833 (8/8) Helix-turn-helix domain
PF09859 (8/8) Oxygenase, catalysing oxidative methylation of damaged DNA
PF06029 (8/8) AlkA N-terminal domain
PF02805 (8/8) Metal binding domain of Ada
PF01035 (8/8) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF02870 (5/8) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
precursor_groups_26522 62.58 +- 37.42 2 0 0 0 0.06 +- 0.04 2 7

PF00756 (2/2) Putative esterase
PF00583 (2/2) Acetyltransferase (GNAT) family
TIGR00842 (1/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF05199 (1/2) GMC oxidoreductase
PF02028 (1/2) BCCT, betaine/carnitine/choline family transporter
PF00732 (1/2) GMC oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family
precursor_groups_29232 27.87 +- 5.97 2 0 0 0 0.15 +- 0.11 2 7

TIGR02286 (2/2) phenylacetic acid degradation protein PaaD
PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF17754 (1/2) MftR C-terminal domain
precursor_groups_49035 54.58 +- 0.35 2 0 0 0 0.20 +- 0.34 2 13

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13578 (2/2) Methyltransferase domain
PF13185 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05199 (2/2) GMC oxidoreductase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
precursor_groups_11902 153.91 +- 63.52 6 0 6 0 0.15 +- 0.27 6 21

PF13578 (6/6) Methyltransferase domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF10604 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF08028 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (6/6) Major Facilitator Superfamily
PF04673 (6/6) Polyketide synthesis cyclase
PF03992 (6/6) Antibiotic biosynthesis monooxygenase
PF03358 (6/6) NADPH-dependent FMN reductase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF01494 (6/6) FAD binding domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00106 (6/6) short chain dehydrogenase
PF00072 (6/6) Response regulator receiver domain
PF01648 (5/6) 4'-phosphopantetheinyl transferase superfamily
TIGR00128 (4/6) malonyl CoA-acyl carrier protein transacylase
PF13822 (4/6) Acyl-CoA carboxylase epsilon subunit
PF01039 (4/6) Carboxyl transferase domain
PF00698 (4/6) Acyl transferase domain
precursor_groups_1226 285.09 +- 257.43 2 0 0 0 0.10 +- 0.22 2 24

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
TIGR01494 (1/2) HAD ATPase, P-type, family IC
TIGR00773 (1/2) Na+/H+ antiporter NhaA
PF13560 (1/2) Helix-turn-helix domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12900 (1/2) Pyridoxamine 5'-phosphate oxidase
PF12724 (1/2) Flavodoxin domain
PF12679 (1/2) ABC-2 family transporter protein
PF08962 (1/2) Domain of unknown function (DUF1876)
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF06965 (1/2) Na+/H+ antiporter 1
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF02254 (1/2) TrkA-N domain
PF02013 (1/2) Cellulose or protein binding domain
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00690 (1/2) Cation transporter/ATPase, N-terminus
PF00689 (1/2) Cation transporting ATPase, C-terminus
PF00582 (1/2) Universal stress protein family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00122 (1/2) E1-E2 ATPase
PF00107 (1/2) Zinc-binding dehydrogenase
PF00005 (1/2) ABC transporter
precursor_groups_1229 1568.12 +- 968.40 40 0 37 31 0.04 +- 0.07 40 11

PF00465 (40/40) Iron-containing alcohol dehydrogenase
PF00202 (40/40) Aminotransferase class-III
PF00069 (40/40) Protein kinase domain
PF00005 (40/40) ABC transporter
PF13649 (39/40) Methyltransferase domain
PF00296 (39/40) Luciferase-like monooxygenase
PF05147 (31/40) Lanthionine synthetase C-like protein
PF00535 (29/40) Glycosyl transferase family 2
PF00483 (28/40) Nucleotidyl transferase
TIGR01208 (27/40) glucose-1-phosphate thymidylyltransferase
PF00132 (25/40) Bacterial transferase hexapeptide (six repeats)
precursor_groups_1228 11.67 +- 4.21 28 0 1 28 0.21 +- 0.11 28 3

PF13360 (28/28) PQQ-like domain
PF11575 (28/28) FhuF 2Fe-2S C-terminal domain
PF00069 (28/28) Protein kinase domain
precursor_groups_2302 78.41 +- 22.70 2 0 2 0 0.04 +- 0.05 2 6

PF17926 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14219 (2/2) Domain of unknown function (DUF4328)
PF13354 (2/2) Beta-lactamase enzyme family
PF08044 (2/2) Domain of unknown function (DUF1707)
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_groups_10997 208.79 +- 64.06 5 0 0 0 0.02 +- 0.01 5 4

PF13454 (5/5) FAD-NAD(P)-binding
PF07969 (5/5) Amidohydrolase family
PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
precursor_groups_81779 160.86 +- 68.07 2 0 2 0 0.11 +- 0.28 2 18

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16911 (2/2) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF09339 (2/2) IclR helix-turn-helix domain
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/2) CoA-transferase family III
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (2/2) Bacterial transcriptional regulator
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_23132 28.90 +- 3.70 3 0 0 0 0.18 +- 0.17 3 1

PF00082 (3/3) Subtilase family
precursor_groups_14003 225.99 +- 29.58 4 0 0 4 0.13 +- 0.11 4 14

TIGR03696 (4/4) RHS repeat-associated core domain
TIGR01643 (4/4) YD repeat (two copies)
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF13517 (4/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13385 (4/4) Concanavalin A-like lectin/glucanases superfamily
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07591 (4/4) Pretoxin HINT domain
PF05593 (4/4) RHS Repeat
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
precursor_groups_20733 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
precursor_groups_69069 466.40 +- 53.60 2 0 0 0 0.01 +- 0.00 2 4

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_51612 139.87 +- 7.56 2 0 0 0 0.04 +- 0.06 2 7

TIGR04364 (2/2) methyltransferase, FxLD system
PF08242 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
precursor_groups_20734 60.74 +- 9.60 4 0 4 0 0.07 +- 0.03 4 10

TIGR01733 (4/4) amino acid adenylation domain
PF14681 (4/4) Uracil phosphoribosyltransferase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF04227 (4/4) Indigoidine synthase A like protein
PF01361 (4/4) Tautomerase enzyme
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
TIGR01549 (3/4) HAD hydrolase, family IA, variant 1
precursor_groups_10503 130.08 +- 54.20 2 0 0 0 0.02 +- 0.02 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09084 (2/2) NMT1/THI5 like
PF07555 (2/2) beta-N-acetylglucosaminidase
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
precursor_groups_15022 32.76 +- 5.45 5 0 0 0 0.16 +- 0.09 5 7

PF07690 (5/5) Major Facilitator Superfamily
PF04131 (5/5) Putative N-acetylmannosamine-6-phosphate epimerase
PF02909 (5/5) Tetracyclin repressor-like, C-terminal domain
PF01494 (5/5) FAD binding domain
PF00701 (5/5) Dihydrodipicolinate synthetase family
PF00480 (5/5) ROK family
PF00440 (5/5) Bacterial regulatory proteins, tetR family
precursor_groups_30923 166.14 +- 91.86 2 0 0 0 0.02 +- 0.01 2 3

PF07702 (2/2) UTRA domain
PF01590 (2/2) GAF domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_8432 37.97 +- 11.97 2 0 0 0 0.20 +- 0.23 2 13

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13602 (2/2) Zinc-binding dehydrogenase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01546 (2/2) Peptidase family M20/M25/M40
PF00672 (2/2) HAMP domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
TIGR04037 (1/2) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (1/2) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF03358 (1/2) NADPH-dependent FMN reductase
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_15024 16.48 +- 0.00 2 0 0 0 0.18 +- 0.21 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF01513 (2/2) ATP-NAD kinase
PF01145 (2/2) SPFH domain / Band 7 family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_51896 211.09 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05593 (2/2) RHS Repeat
PF03527 (2/2) RHS protein
precursor_groups_10509 122.11 +- 71.18 6 0 0 0 0.22 +- 0.28 6 17

TIGR00765 (6/6) YihY family inner membrane protein
TIGR00105 (6/6) ribosomal protein bL31
PF11941 (6/6) Domain of unknown function (DUF3459)
PF05922 (6/6) Peptidase inhibitor I9
PF03631 (6/6) Virulence factor BrkB
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF01756 (6/6) Acyl-CoA oxidase
PF01497 (6/6) Periplasmic binding protein
PF01197 (6/6) Ribosomal protein L31
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00294 (6/6) pfkB family carbohydrate kinase
PF00128 (6/6) Alpha amylase, catalytic domain
PF00082 (6/6) Subtilase family
PF07705 (5/6) CARDB
PF00754 (5/6) F5/8 type C domain
PF01032 (3/6) FecCD transport family
PF00005 (3/6) ABC transporter
precursor_groups_10508 148.12 +- 97.30 7 0 0 0 0.11 +- 0.20 7 12

TIGR01764 (7/7) DNA binding domain, excisionase family
PF13245 (7/7) AAA domain
PF12728 (7/7) Helix-turn-helix domain
PF12697 (7/7) Alpha/beta hydrolase family
PF12679 (7/7) ABC-2 family transporter protein
PF03033 (7/7) Glycosyltransferase family 28 N-terminal domain
PF01551 (7/7) Peptidase family M23
PF00392 (7/7) Bacterial regulatory proteins, gntR family
PF00005 (7/7) ABC transporter
PF13673 (4/7) Acetyltransferase (GNAT) domain
PF13411 (4/7) MerR HTH family regulatory protein
PF07739 (4/7) TipAS antibiotic-recognition domain
precursor_groups_72534 580.50 +- 0.00 2 0 0 0 0.02 +- 0.00 2 7

TIGR01767 (2/2) S-methyl-5-thioribose kinase
TIGR00512 (2/2) S-methyl-5-thioribose-1-phosphate isomerase
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01008 (2/2) Initiation factor 2 subunit family
PF00005 (2/2) ABC transporter
precursor_groups_35217 1505.26 +- 0.00 2 0 0 2 0.01 +- 0.02 2 11

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00702 (2/2) YcaO-type kinase domain
PF13649 (2/2) Methyltransferase domain
PF08281 (2/2) Sigma-70, region 4
PF08241 (2/2) Methyltransferase domain
PF07812 (2/2) TfuA-like protein
PF07479 (2/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF04542 (2/2) Sigma-70 region 2
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01614 (2/2) Bacterial transcriptional regulator
PF01210 (2/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
precursor_groups_23648 187.66 +- 22.33 4 0 1 0 0.06 +- 0.02 4 9

TIGR01187 (4/4) polyamine ABC transporter, ATP-binding protein
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08402 (4/4) TOBE domain
PF01593 (4/4) Flavin containing amine oxidoreductase
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00005 (4/4) ABC transporter
PF00171 (3/4) Aldehyde dehydrogenase family
precursor_groups_49680 36.86 +- 0.00 2 0 2 0 0.05 +- 0.08 2 2

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_66249 334.62 +- 22.62 2 0 2 0 0.03 +- 0.01 2 6

PF13560 (2/2) Helix-turn-helix domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_1134 36.19 +- 0.00 2 0 0 0 0.25 +- 0.16 2 6

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF12708 (2/2) Pectate lyase superfamily protein
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_1137 203.30 +- 256.64 4 0 0 0 0.04 +- 0.05 4 2

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase
precursor_groups_482 66.21 +- 58.08 4 0 4 0 0.21 +- 0.24 4 15

PF02541 (4/4) Ppx/GppA phosphatase family
TIGR00711 (3/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00537 (3/4) putative methylase
PF14518 (3/4) Iron-containing redox enzyme
PF07690 (3/4) Major Facilitator Superfamily
PF05175 (3/4) Methyltransferase small domain
TIGR03797 (2/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR00377 (2/4) anti-anti-sigma factor
PF13466 (2/4) STAS domain
PF13437 (2/4) HlyD family secretion protein
PF09360 (2/4) Iron-binding zinc finger CDGSH type
PF03412 (2/4) Peptidase C39 family
PF00664 (2/4) ABC transporter transmembrane region
PF00005 (2/4) ABC transporter
precursor_groups_23646 330.70 +- 247.05 5 0 0 0 0.05 +- 0.04 5 8

TIGR01821 (5/5) 5-aminolevulinic acid synthase
PF07690 (5/5) Major Facilitator Superfamily
PF06224 (5/5) Winged helix DNA-binding domain
PF03466 (5/5) LysR substrate binding domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00155 (5/5) Aminotransferase class I and II
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_484 226.39 +- 191.36 9 0 1 0 0.12 +- 0.25 9 2

PF01135 (9/9) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13560 (5/9) Helix-turn-helix domain
precursor_groups_67071 285.17 +- 3.72 2 0 0 0 0.03 +- 0.03 2 5

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF01425 (2/2) Amidase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13546 (1/2) DDE superfamily endonuclease
PF01526 (1/2) Tn3 transposase DDE domain
precursor_groups_40558 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_groups_5147 157.94 +- 93.38 3 0 0 0 0.06 +- 0.13 3 2

PF10824 (3/3) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (3/3) Proteins of 100 residues with WXG
precursor_groups_2309 36.02 +- 16.76 2 0 0 0 0.08 +- 0.08 2 4

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF09243 (1/2) Mitochondrial small ribosomal subunit Rsm22
PF08877 (1/2) MepB protein
PF03009 (1/2) Glycerophosphoryl diester phosphodiesterase family
precursor_groups_27322 30.04 +- 9.45 4 0 4 0 0.11 +- 0.18 4 5

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12697 (4/4) Alpha/beta hydrolase family
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF00069 (4/4) Protein kinase domain
precursor_groups_6004 221.57 +- 119.32 10 0 0 0 0.04 +- 0.05 10 13

PF18130 (10/10) ATP-grasp N-terminal domain
PF16259 (10/10) Domain of unknown function (DUF4913)
PF13535 (10/10) ATP-grasp domain
PF07690 (10/10) Major Facilitator Superfamily
PF03771 (10/10) Domain of unknown function (DUF317)
PF01638 (10/10) HxlR-like helix-turn-helix
PF08239 (9/10) Bacterial SH3 domain
PF00583 (9/10) Acetyltransferase (GNAT) family
PF18603 (8/10) L-amino acid ligase C-terminal domain 2
PF12307 (8/10) Protein of unknown function (DUF3631)
PF01555 (8/10) DNA methylase
PF17802 (7/10) Prealbumin-like fold domain
TIGR01167 (6/10) LPXTG cell wall anchor domain
precursor_groups_8342 202.33 +- 316.65 6 0 0 0 0.15 +- 0.33 6 8

PF14029 (6/6) Protein of unknown function (DUF4244)
PF00482 (6/6) Type II secretion system (T2SS), protein F
TIGR03819 (5/6) helicase/secretion neighborhood ATPase
TIGR03816 (5/6) helicase/secretion neighborhood TadE-like protein
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF00437 (5/6) Type II/IV secretion system protein
TIGR03815 (4/6) helicase/secretion neighborhood CpaE-like protein
PF01656 (3/6) CobQ/CobB/MinD/ParA nucleotide binding domain
precursor_groups_15756 211.18 +- 96.47 5 0 5 0 0.02 +- 0.01 5 3

TIGR03930 (5/5) WXG100 family type VII secretion target
PF06013 (5/5) Proteins of 100 residues with WXG
PF00082 (5/5) Subtilase family
precursor_groups_60625 152.46 +- 41.04 2 0 2 0 0.01 +- 0.01 2 2

PF13810 (2/2) Domain of unknown function (DUF4185)
PF08310 (2/2) LGFP repeat
precursor_groups_8501 13.66 +- 4.77 2 0 2 0 0.17 +- 0.16 2 1

PF00756 (2/2) Putative esterase
precursor_groups_63640 282.30 +- 147.70 2 0 1 0 0.04 +- 0.06 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF02633 (2/2) Creatinine amidohydrolase
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00459 (1/2) Inositol monophosphatase family
precursor_groups_4094 163.90 +- 101.63 2 0 0 0 0.10 +- 0.14 2 11

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF13460 (1/2) NAD(P)H-binding
PF12697 (1/2) Alpha/beta hydrolase family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (1/2) FAD binding domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00106 (1/2) short chain dehydrogenase
PF00072 (1/2) Response regulator receiver domain
PF00027 (1/2) Cyclic nucleotide-binding domain
precursor_groups_10478 58.62 +- 20.32 8 0 0 0 0.20 +- 0.07 8 13

PF18603 (8/8) L-amino acid ligase C-terminal domain 2
PF18130 (8/8) ATP-grasp N-terminal domain
PF13535 (8/8) ATP-grasp domain
PF04016 (8/8) Putative heavy-metal chelation
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF13649 (7/8) Methyltransferase domain
PF13378 (7/8) Enolase C-terminal domain-like
PF07690 (7/8) Major Facilitator Superfamily
PF02746 (7/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (7/8) Binding-protein-dependent transport system inner membrane component
PF00496 (7/8) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (7/8) ABC transporter
PF08352 (5/8) Oligopeptide/dipeptide transporter, C-terminal region
precursor_groups_33360 106.97 +- 28.68 3 0 0 0 0.12 +- 0.15 3 10

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
precursor_groups_36242 209.81 +- 69.57 3 0 0 0 0.02 +- 0.03 3 4

TIGR01926 (3/3) uncharacterized peroxidase-related enzyme
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
precursor_groups_50676 280.92 +- 239.08 2 0 2 0 0.05 +- 0.14 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13621 (2/2) Cupin-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_15113 407.14 +- 213.85 7 0 0 0 0.01 +- 0.00 7 6

PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF13535 (7/7) ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02955 (7/7) Prokaryotic glutathione synthetase, ATP-grasp domain
PF02222 (7/7) ATP-grasp domain
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
precursor_groups_50672 238.97 +- 31.03 2 0 2 0 0.04 +- 0.05 2 14

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF12680 (2/2) SnoaL-like domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03704 (2/2) Bacterial transcriptional activator domain
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_20597 296.34 +- 213.33 5 0 2 0 0.07 +- 0.22 5 26

TIGR02100 (5/5) glycogen debranching enzyme GlgX
TIGR01515 (5/5) 1,4-alpha-glucan branching enzyme
TIGR00377 (5/5) anti-anti-sigma factor
PF18085 (5/5) Maltokinase N-terminal cap domain
PF17124 (5/5) ThiJ/PfpI family-like
PF13614 (5/5) AAA domain
PF13581 (5/5) Histidine kinase-like ATPase domain
PF13546 (5/5) DDE superfamily endonuclease
PF13466 (5/5) STAS domain
PF13460 (5/5) NAD(P)H-binding
PF13380 (5/5) CoA binding domain
PF11896 (5/5) Domain of unknown function (DUF3416)
PF07690 (5/5) Major Facilitator Superfamily
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF07221 (5/5) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (5/5) EthD domain
PF02922 (5/5) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (5/5) DJ-1/PfpI family
PF01740 (5/5) STAS domain
PF00483 (5/5) Nucleotidyl transferase
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF00128 (5/5) Alpha amylase, catalytic domain
PF02806 (4/5) Alpha amylase, C-terminal all-beta domain
PF00132 (4/5) Bacterial transferase hexapeptide (six repeats)
precursor_groups_14750 207.41 +- 9.31 2 0 0 0 0.09 +- 0.16 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01120 (2/2) Alpha-L-fucosidase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
PF17754 (1/2) MftR C-terminal domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF10518 (1/2) TAT (twin-arginine translocation) pathway signal sequence
PF07859 (1/2) alpha/beta hydrolase fold
PF00754 (1/2) F5/8 type C domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_28584 555.59 +- 532.35 4 0 0 0 0.02 +- 0.02 4 10

PF07729 (4/4) FCD domain
PF07690 (4/4) Major Facilitator Superfamily
PF05378 (4/4) Hydantoinase/oxoprolinase N-terminal region
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02538 (4/4) Hydantoinase B/oxoprolinase
PF01968 (4/4) Hydantoinase/oxoprolinase
PF01558 (4/4) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF00857 (4/4) Isochorismatase family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00155 (4/4) Aminotransferase class I and II
precursor_groups_66484 172.58 +- 20.92 2 0 2 0 0.03 +- 0.04 2 8

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13521 (2/2) AAA domain
PF12680 (2/2) SnoaL-like domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05655 (2/2) Pseudomonas avirulence D protein (AvrD)
PF03358 (2/2) NADPH-dependent FMN reductase
precursor_groups_61591 306.43 +- 83.57 2 0 2 0 0.01 +- 0.00 2 7

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_312 42.67 +- 14.67 2 0 0 0 0.11 +- 0.18 2 5

PF16670 (2/2) Phosphoinositide phospholipase C, Ca2+-dependent
PF13751 (2/2) Transposase DDE domain
PF13655 (2/2) N-terminal domain of reverse transcriptase
PF03795 (2/2) YCII-related domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_groups_9329 147.43 +- 110.57 2 0 0 0 0.03 +- 0.05 2 3

PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00107 (2/2) Zinc-binding dehydrogenase
PF14667 (1/2) Polysaccharide biosynthesis C-terminal domain
precursor_groups_317 53.14 +- 8.71 3 0 0 0 0.04 +- 0.02 3 3

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_groups_12331 148.02 +- 180.88 3 0 1 0 0.09 +- 0.12 3 7

PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF06439 (3/3) Domain of Unknown Function (DUF1080)
PF06283 (3/3) Trehalose utilisation
PF03422 (3/3) Carbohydrate binding module (family 6)
PF00801 (3/3) PKD domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00348 (2/3) Polyprenyl synthetase
precursor_groups_45473 144.24 +- 21.37 3 0 0 0 0.02 +- 0.02 3 4

PF13560 (3/3) Helix-turn-helix domain
PF08241 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
precursor_groups_72143 371.43 +- 148.57 2 0 0 0 0.02 +- 0.03 2 8

TIGR03168 (2/2) hexose kinase, 1-phosphofructokinase family
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00167 (1/2) ketose-bisphosphate aldolase
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
precursor_groups_72141 173.00 +- 87.00 2 0 0 0 0.02 +- 0.03 2 4

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_24037 22.78 +- 1.41 2 0 2 0 0.20 +- 0.14 2 12

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00106 (1/2) short chain dehydrogenase
precursor_groups_1355 181.21 +- 64.64 3 0 0 0 0.06 +- 0.07 3 1

PF00067 (3/3) Cytochrome P450
precursor_groups_23731 606.97 +- 393.72 5 0 5 0 0.08 +- 0.11 5 28

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (5/5) Male sterility protein
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (5/5) Copper chaperone PCu(A)C
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (5/5) DJ-1/PfpI family
PF01497 (5/5) Periplasmic binding protein
PF01032 (5/5) FecCD transport family
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00005 (5/5) ABC transporter
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (4/5) heavy metal translocating P-type ATPase
PF08281 (4/5) Sigma-70, region 4
PF04542 (4/5) Sigma-70 region 2
PF03929 (4/5) PepSY-associated TM region
PF01794 (4/5) Ferric reductase like transmembrane component
PF00702 (4/5) haloacid dehalogenase-like hydrolase
PF00403 (4/5) Heavy-metal-associated domain
PF00122 (4/5) E1-E2 ATPase
precursor_groups_2818 199.11 +- 60.89 2 0 0 0 0.03 +- 0.05 2 10

PF00932 (2/2) Lamin Tail Domain
TIGR03668 (1/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family
PF12697 (1/2) Alpha/beta hydrolase family
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01565 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_9108 117.34 +- 48.52 2 0 2 0 0.03 +- 0.04 2 4

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_5853 157.50 +- 102.52 6 0 0 0 0.03 +- 0.05 6 2

PF06737 (6/6) Transglycosylase-like domain
PF01476 (6/6) LysM domain
precursor_groups_63374 259.00 +- 1.00 2 0 0 2 0.01 +- 0.00 2 4

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
precursor_groups_16445 103.19 +- 52.98 4 0 0 0 0.02 +- 0.03 4 2

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF01243 (4/4) Pyridoxamine 5'-phosphate oxidase
precursor_groups_46410 16.84 +- 1.44 2 0 0 0 0.18 +- 0.17 2 9

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF14525 (2/2) AraC-binding-like domain
PF14273 (2/2) Domain of unknown function (DUF4360)
PF12833 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00089 (2/2) Trypsin
precursor_groups_2815 269.94 +- 159.80 29 0 29 0 0.03 +- 0.10 29 13

TIGR00709 (29/29) 2,4-diaminobutyrate 4-transaminase
PF07690 (29/29) Major Facilitator Superfamily
PF00696 (29/29) Amino acid kinase family
PF00202 (29/29) Aminotransferase class-III
TIGR00657 (28/29) aspartate kinase
PF13434 (28/29) L-lysine 6-monooxygenase (NADPH-requiring)
PF04204 (28/29) Homoserine O-succinyltransferase
PF00668 (26/29) Condensation domain
PF00501 (26/29) AMP-binding enzyme
TIGR01733 (25/29) amino acid adenylation domain
PF13193 (25/29) AMP-binding enzyme C-terminal domain
PF00975 (25/29) Thioesterase domain
PF00550 (25/29) Phosphopantetheine attachment site
precursor_groups_28066 15.72 +- 2.87 3 0 0 0 0.20 +- 0.18 3 5

PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02057 (3/3) Glycosyl hydrolase family 59
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_10987 157.77 +- 152.42 5 0 0 0 0.09 +- 0.14 5 3

PF00082 (5/5) Subtilase family
PF05425 (4/5) Copper resistance protein D
PF02515 (4/5) CoA-transferase family III
precursor_groups_50876 252.33 +- 137.67 2 0 0 0 0.02 +- 0.04 2 4

PF04203 (2/2) Sortase domain
PF01590 (2/2) GAF domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_61662 280.41 +- 130.12 2 0 0 0 0.07 +- 0.12 2 12

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_groups_32165 271.79 +- 83.75 3 0 0 0 0.14 +- 0.20 3 17

PF13508 (3/3) Acetyltransferase (GNAT) domain
PF11941 (3/3) Domain of unknown function (DUF3459)
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07705 (3/3) CARDB
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01756 (3/3) Acyl-CoA oxidase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00754 (3/3) F5/8 type C domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
PF00128 (3/3) Alpha amylase, catalytic domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_70965 72.61 +- 20.72 2 0 0 0 0.20 +- 0.31 2 13

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF03869 (1/2) Arc-like DNA binding domain
precursor_groups_57859 614.31 +- 165.69 2 0 0 0 0.02 +- 0.07 2 13

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF13649 (2/2) Methyltransferase domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07398 (2/2) MDMPI C-terminal domain
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00303 (2/2) Thymidylate synthase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (1/2) Acyl-CoA oxidase
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00106 (1/2) short chain dehydrogenase
precursor_groups_36424 1877.33 +- 808.40 3 0 0 0 0.01 +- 0.01 3 28

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
TIGR00481 (3/3) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF14765 (3/3) Polyketide synthase dehydratase
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF12697 (3/3) Alpha/beta hydrolase family
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF08659 (3/3) KR domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF06684 (3/3) Amino acid synthesis
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01614 (3/3) Bacterial transcriptional regulator
PF01554 (3/3) MatE
PF01494 (3/3) FAD binding domain
PF01161 (3/3) Phosphatidylethanolamine-binding protein
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_46897 160.60 +- 97.40 2 0 0 0 0.10 +- 0.28 2 4

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_19183 73.52 +- 37.13 5 0 5 5 0.07 +- 0.06 5 5

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (5/5) Asparagine synthase
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
precursor_groups_61469 40.98 +- 4.64 2 0 1 0 0.10 +- 0.08 2 8

TIGR01234 (2/2) ribulokinase
PF13377 (2/2) Periplasmic binding protein-like domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_2495 23.42 +- 15.64 3 0 0 0 0.15 +- 0.14 3 3

TIGR01356 (3/3) 3-phosphoshikimate 1-carboxyvinyltransferase
PF00275 (3/3) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF13302 (2/3) Acetyltransferase (GNAT) domain
precursor_groups_79714 2072.00 +- 8.00 2 0 0 0 0.01 +- 0.00 2 7

PF08386 (2/2) TAP-like protein
PF07702 (2/2) UTRA domain
PF01380 (2/2) SIS domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_5218 17.00 +- 3.31 2 0 0 0 0.21 +- 0.25 2 7

PF13439 (2/2) Glycosyltransferase Family 4
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
PF00534 (2/2) Glycosyl transferases group 1
PF11720 (1/2) Peptidase inhibitor I78 family
precursor_groups_17666 32.91 +- 17.84 5 0 5 5 0.13 +- 0.11 5 6

PF14518 (5/5) Iron-containing redox enzyme
PF13191 (5/5) AAA ATPase domain
PF13185 (5/5) GAF domain
PF04055 (5/5) Radical SAM superfamily
PF00211 (5/5) Adenylate and Guanylate cyclase catalytic domain
PF00082 (5/5) Subtilase family
precursor_groups_72030 177.75 +- 80.25 2 0 1 0 0.01 +- 0.01 2 3

PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
precursor_groups_21249 356.58 +- 209.63 4 0 3 0 0.03 +- 0.06 4 6

PF17827 (4/4) PrmC N-terminal domain
PF13649 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01266 (4/4) FAD dependent oxidoreductase
PF00440 (3/4) Bacterial regulatory proteins, tetR family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
precursor_groups_63202 2858.53 +- 2313.20 2 0 2 0 0.03 +- 0.15 2 27

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13579 (2/2) Glycosyl transferase 4-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04909 (2/2) Amidohydrolase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02449 (2/2) Beta-galactosidase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01180 (2/2) Dihydroorotate dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_groups_2253 25.59 +- 0.41 2 0 0 0 0.08 +- 0.07 2 5

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13641 (2/2) Glycosyltransferase like family 2
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF01522 (2/2) Polysaccharide deacetylase
PF01266 (2/2) FAD dependent oxidoreductase
precursor_groups_46251 22.97 +- 12.22 2 0 2 0 0.13 +- 0.14 2 3

PF06236 (2/2) Tyrosinase co-factor MelC1
PF00264 (2/2) Common central domain of tyrosinase
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
precursor_groups_46520 1206.67 +- 117.85 3 0 3 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF05114 (3/3) Protein of unknown function (DUF692)
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF06999 (2/3) Sucrase/ferredoxin-like
precursor_groups_15808 44.47 +- 16.06 3 0 3 0 0.19 +- 0.21 3 8

PF05988 (3/3) Bacterial protein of unknown function (DUF899)
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF14310 (2/3) Fibronectin type III-like domain
PF09362 (2/3) Domain of unknown function (DUF1996)
PF02836 (2/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/3) Glycosyl hydrolase family 3 N terminal domain
PF00754 (2/3) F5/8 type C domain
precursor_groups_46259 217.51 +- 111.53 3 0 3 0 0.08 +- 0.21 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_57128 1340.26 +- 160.83 2 0 0 0 0.01 +- 0.01 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_50706 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
precursor_groups_463 90.96 +- 79.46 3 0 1 0 0.10 +- 0.16 3 6

PF02416 (3/3) mttA/Hcf106 family
PF12833 (2/3) Helix-turn-helix domain
PF12625 (2/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF00743 (2/3) Flavin-binding monooxygenase-like
PF00171 (2/3) Aldehyde dehydrogenase family
PF00106 (2/3) short chain dehydrogenase
precursor_groups_462 511.46 +- 450.93 68 0 40 1 0.06 +- 0.18 68 15

TIGR01850 (66/68) N-acetyl-gamma-glutamyl-phosphate reductase
PF01118 (66/68) Semialdehyde dehydrogenase, NAD binding domain
PF08443 (63/68) RimK-like ATP-grasp domain
PF02779 (58/68) Transketolase, pyrimidine binding domain
PF00456 (58/68) Transketolase, thiamine diphosphate binding domain
TIGR00768 (57/68) alpha-L-glutamate ligase, RimK family
PF00696 (52/68) Amino acid kinase family
PF01546 (50/68) Peptidase family M20/M25/M40
TIGR01902 (48/68) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01041 (42/68) DegT/DnrJ/EryC1/StrS aminotransferase family
PF07690 (38/68) Major Facilitator Superfamily
PF13535 (36/68) ATP-grasp domain
PF18603 (35/68) L-amino acid ligase C-terminal domain 2
PF18130 (34/68) ATP-grasp N-terminal domain
PF00501 (34/68) AMP-binding enzyme
precursor_groups_46039 398.33 +- 178.68 3 0 0 0 0.02 +- 0.01 3 8

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_57432 65.67 +- 46.13 2 0 0 0 0.21 +- 0.23 2 11

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03767 (2/2) HAD superfamily, subfamily IIIB (Acid phosphatase)
PF01872 (2/2) RibD C-terminal domain
TIGR00057 (1/2) tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family
PF13191 (1/2) AAA ATPase domain
PF04237 (1/2) YjbR
PF01300 (1/2) Telomere recombination
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter
precursor_groups_57121 541.21 +- 462.12 2 0 2 0 0.08 +- 0.25 2 8

PF13732 (2/2) Domain of unknown function (DUF4162)
PF01061 (2/2) ABC-2 type transporter
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF01134 (1/2) Glucose inhibited division protein A
PF00561 (1/2) alpha/beta hydrolase fold
precursor_groups_32305 64.76 +- 3.28 2 0 1 0 0.23 +- 0.22 2 18

TIGR00839 (2/2) aspartate ammonia-lyase
PF10415 (2/2) Fumarase C C-terminus
PF07729 (2/2) FCD domain
PF06089 (2/2) L-asparaginase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF00206 (2/2) Lyase
PF18631 (1/2) Cucumopine synthase C-terminal helical bundle domain
PF17203 (1/2) Single cache domain 3
PF14689 (1/2) Sensor_kinase_SpoOB-type, alpha-helical domain
PF09339 (1/2) IclR helix-turn-helix domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01266 (1/2) FAD dependent oxidoreductase
PF00989 (1/2) PAS fold
PF00501 (1/2) AMP-binding enzyme
PF00171 (1/2) Aldehyde dehydrogenase family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_57435 192.32 +- 7.43 2 0 2 0 0.12 +- 0.31 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_262 168.57 +- 128.57 2 0 0 0 0.11 +- 0.09 2 17

TIGR02133 (1/2) ribose 5-phosphate isomerase
TIGR01552 (1/2) prevent-host-death family protein
PF16896 (1/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12647 (1/2) RNHCP domain
PF07690 (1/2) Major Facilitator Superfamily
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04389 (1/2) Peptidase family M28
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02734 (1/2) DAK2 domain
PF02733 (1/2) Dak1 domain
PF02604 (1/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02502 (1/2) Ribose/Galactose Isomerase
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00501 (1/2) AMP-binding enzyme
PF00121 (1/2) Triosephosphate isomerase
precursor_groups_265 117.80 +- 40.83 3 0 1 0 0.06 +- 0.09 3 9

TIGR02983 (2/3) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/3) Bacterial Ig domain
PF13411 (2/3) MerR HTH family regulatory protein
PF08281 (2/3) Sigma-70, region 4
PF07739 (2/3) TipAS antibiotic-recognition domain
PF04542 (2/3) Sigma-70 region 2
PF03734 (2/3) L,D-transpeptidase catalytic domain
PF03033 (2/3) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_47784 180.22 +- 13.28 2 0 0 0 0.18 +- 0.24 2 10

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
PF03055 (1/2) Retinal pigment epithelial membrane protein
precursor_groups_46348 82.76 +- 8.47 2 0 0 0 0.07 +- 0.12 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
TIGR03930 (1/2) WXG100 family type VII secretion target
PF06013 (1/2) Proteins of 100 residues with WXG
precursor_groups_29478 309.60 +- 206.40 2 0 2 0 0.01 +- 0.01 2 2

PF07722 (2/2) Peptidase C26
PF02627 (2/2) Carboxymuconolactone decarboxylase family
precursor_groups_16592 26.75 +- 3.45 5 0 0 0 0.08 +- 0.14 5 14

TIGR02680 (5/5) TIGR02680 family protein
TIGR02678 (5/5) TIGR02678 family protein
TIGR02677 (5/5) TIGR02677 family protein
TIGR00484 (5/5) translation elongation factor G
PF14492 (5/5) Elongation Factor G, domain II
PF13558 (5/5) Putative exonuclease SbcCD, C subunit
PF10127 (5/5) RNA repair pathway DNA polymerase beta family
PF09983 (5/5) Uncharacterized protein conserved in bacteria C-term(DUF2220)
PF09661 (5/5) Protein of unknown function (DUF2398)
PF09660 (5/5) Protein of unknown function (DUF2397)
PF03764 (5/5) Elongation factor G, domain IV
PF03144 (5/5) Elongation factor Tu domain 2
PF00679 (5/5) Elongation factor G C-terminus
PF00009 (5/5) Elongation factor Tu GTP binding domain
precursor_groups_1364 161.20 +- 33.80 2 0 0 1 0.06 +- 0.04 2 16

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF13701 (1/2) Transposase DDE domain group 1
PF13649 (1/2) Methyltransferase domain
PF13360 (1/2) PQQ-like domain
PF08281 (1/2) Sigma-70, region 4
PF05336 (1/2) L-rhamnose mutarotase
PF05175 (1/2) Methyltransferase small domain
PF04909 (1/2) Amidohydrolase
PF01636 (1/2) Phosphotransferase enzyme family
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00293 (1/2) NUDIX domain
PF00005 (1/2) ABC transporter
precursor_groups_71761 8.39 +- 0.14 2 0 0 0 0.24 +- 0.08 2 2

PF01341 (2/2) Glycosyl hydrolases family 6
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_29473 75.06 +- 30.73 3 0 3 0 0.14 +- 0.19 3 8

PF12833 (3/3) Helix-turn-helix domain
PF03259 (3/3) Roadblock/LC7 domain
PF01965 (3/3) DJ-1/PfpI family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (3/3) Aldehyde dehydrogenase family
PF04237 (2/3) YjbR
precursor_groups_4638 1058.04 +- 888.53 15 0 12 0 0.05 +- 0.18 15 18

TIGR01307 (15/15) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13535 (15/15) ATP-grasp domain
PF13480 (15/15) Acetyltransferase (GNAT) domain
PF13115 (15/15) YtkA-like
PF04389 (15/15) Peptidase family M28
PF02627 (15/15) Carboxymuconolactone decarboxylase family
PF01676 (15/15) Metalloenzyme superfamily
PF00664 (15/15) ABC transporter transmembrane region
PF00403 (15/15) Heavy-metal-associated domain
PF00275 (15/15) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (15/15) Aminotransferase class I and II
PF00117 (15/15) Glutamine amidotransferase class-I
PF00005 (15/15) ABC transporter
TIGR01525 (14/15) heavy metal translocating P-type ATPase
TIGR01356 (14/15) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13549 (14/15) ATP-grasp domain
PF00702 (14/15) haloacid dehalogenase-like hydrolase
PF00122 (14/15) E1-E2 ATPase
precursor_groups_35830 10.59 +- 0.34 3 0 0 0 0.19 +- 0.09 3 5

TIGR02306 (3/3) RNA ligase
PF13602 (3/3) Zinc-binding dehydrogenase
PF09414 (3/3) RNA ligase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (2/3) Zinc-binding dehydrogenase
precursor_groups_27203 906.50 +- 3.50 4 0 4 4 0.01 +- 0.00 4 11

TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
TIGR00027 (4/4) methyltransferase, TIGR00027 family
PF13537 (4/4) Glutamine amidotransferase domain
PF12146 (4/4) Serine aminopeptidase, S33
PF11066 (4/4) Protein of unknown function (DUF2867)
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07366 (4/4) SnoaL-like polyketide cyclase
PF04072 (4/4) Leucine carboxyl methyltransferase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF00733 (4/4) Asparagine synthase
PF00155 (4/4) Aminotransferase class I and II
precursor_groups_16626 146.83 +- 113.17 2 0 0 0 0.03 +- 0.06 2 2

PF01872 (2/2) RibD C-terminal domain
PF01738 (2/2) Dienelactone hydrolase family
precursor_groups_42175 212.25 +- 174.75 2 0 0 0 0.05 +- 0.08 2 9

TIGR01995 (2/2) PTS system, beta-glucoside-specific IIABC component
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00232 (2/2) Glycosyl hydrolase family 1
PF13751 (1/2) Transposase DDE domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
precursor_groups_82974 30.77 +- 0.22 2 0 0 0 0.19 +- 0.36 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_groups_860 139.87 +- 14.51 2 0 2 0 0.19 +- 0.23 2 39

TIGR03494 (2/2) salicylate synthase
TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00581 (2/2) Rhodanese-like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
TIGR01300 (1/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (1/2) Domain of unknown function (DUF4040)
PF07690 (1/2) Major Facilitator Superfamily
PF05331 (1/2) Protein of unknown function (DUF742)
PF04237 (1/2) YjbR
PF04066 (1/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (1/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03466 (1/2) LysR substrate binding domain
PF03334 (1/2) Na+/H+ antiporter subunit
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF01899 (1/2) Na+/H+ ion antiporter subunit
PF01590 (1/2) GAF domain
PF00662 (1/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/2) Proton-conducting membrane transporter
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_15931 380.73 +- 115.42 2 0 0 2 0.03 +- 0.03 2 8

PF14099 (2/2) Polysaccharide lyase
PF13377 (2/2) Periplasmic binding protein-like domain
PF13360 (2/2) PQQ-like domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF06283 (1/2) Trehalose utilisation
precursor_groups_45860 63.98 +- 1.65 2 0 2 0 0.23 +- 0.31 2 11

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13478 (2/2) XdhC Rossmann domain
PF07883 (2/2) Cupin domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_9254 110.55 +- 29.77 10 0 0 0 0.13 +- 0.26 10 10

PF08795 (10/10) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (10/10) Animal haem peroxidase
PF02585 (10/10) GlcNAc-PI de-N-acetylase
PF01061 (10/10) ABC-2 type transporter
PF00933 (10/10) Glycosyl hydrolase family 3 N terminal domain
PF00582 (10/10) Universal stress protein family
PF00199 (10/10) Catalase
PF00005 (10/10) ABC transporter
TIGR00229 (7/10) PAS domain S-box protein
PF00196 (7/10) Bacterial regulatory proteins, luxR family
precursor_groups_24694 125.26 +- 77.54 3 0 0 0 0.04 +- 0.08 3 3

PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF04266 (3/3) ASCH domain
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_groups_39316 193.01 +- 38.01 3 0 3 0 0.09 +- 0.20 3 25

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF13649 (3/3) Methyltransferase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08281 (3/3) Sigma-70, region 4
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF03824 (3/3) High-affinity nickel-transport protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
precursor_groups_16275 1231.81 +- 798.15 4 0 4 0 0.04 +- 0.12 4 12

TIGR03947 (4/4) capreomycidine synthase
TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03621 (4/4) MbtH-like protein
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00266 (4/4) Aminotransferase class-V
PF00155 (4/4) Aminotransferase class I and II
precursor_groups_32433 353.86 +- 232.14 3 0 0 0 0.06 +- 0.10 3 3

PF11338 (3/3) Protein of unknown function (DUF3140)
PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF00857 (3/3) Isochorismatase family
precursor_groups_32542 637.66 +- 461.28 3 0 3 3 0.02 +- 0.02 3 15

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF17837 (3/3) 4'-phosphopantetheinyl transferase N-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12146 (3/3) Serine aminopeptidase, S33
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF05138 (3/3) Phenylacetic acid catabolic protein
PF04055 (3/3) Radical SAM superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_27973 129.50 +- 0.50 2 0 2 0 0.02 +- 0.01 2 5

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_17490 1234.12 +- 1365.60 6 0 0 0 0.02 +- 0.02 6 6

TIGR03930 (6/6) WXG100 family type VII secretion target
TIGR03921 (6/6) type VII secretion-associated serine protease mycosin
TIGR03919 (6/6) type VII secretion protein EccB
PF06013 (6/6) Proteins of 100 residues with WXG
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF00082 (6/6) Subtilase family
precursor_groups_56899 141.49 +- 102.26 2 0 0 0 0.13 +- 0.28 2 6

PF14742 (2/2) N-terminal domain of (some) glycogen debranching enzymes
PF11941 (2/2) Domain of unknown function (DUF3459)
PF06202 (2/2) Amylo-alpha-1,6-glucosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_35230 453.00 +- 63.00 2 0 2 2 0.01 +- 0.01 2 5

PF13454 (2/2) FAD-NAD(P)-binding
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_56231 118.43 +- 0.00 2 0 0 0 0.07 +- 0.10 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_51165 42.13 +- 0.00 2 0 2 0 0.21 +- 0.34 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13649 (2/2) Methyltransferase domain
PF13602 (2/2) Zinc-binding dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01039 (2/2) Carboxyl transferase domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_32238 370.50 +- 19.50 2 0 0 0 0.01 +- 0.00 2 6

PF13671 (2/2) AAA domain
PF13483 (2/2) Beta-lactamase superfamily domain
PF12697 (2/2) Alpha/beta hydrolase family
PF09037 (2/2) Stf0 sulphotransferase
PF07690 (2/2) Major Facilitator Superfamily
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_58650 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_groups_24743 104.00 +- 0.00 2 0 0 0 0.02 +- 0.01 2 4

PF13602 (2/2) Zinc-binding dehydrogenase
PF11706 (2/2) CGNR zinc finger
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07336 (2/2) Putative stress-induced transcription regulator
precursor_groups_5459 205.04 +- 64.88 9 0 1 0 0.03 +- 0.08 9 7

TIGR03920 (9/9) type VII secretion integral membrane protein EccD
TIGR03919 (9/9) type VII secretion protein EccB
PF08817 (9/9) WXG100 protein secretion system (Wss), protein YukD
PF05108 (9/9) Type VII secretion system ESX-1, transport TM domain B
PF04488 (9/9) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (9/9) YbaB/EbfC DNA-binding family
PF07179 (8/9) SseB protein N-terminal domain
precursor_groups_5968 303.47 +- 370.04 3 0 0 0 0.07 +- 0.20 3 6

PF13462 (2/3) Thioredoxin
PF11292 (2/3) Protein of unknown function (DUF3093)
PF09678 (2/3) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF05425 (2/3) Copper resistance protein D
PF04234 (2/3) CopC domain
PF00484 (2/3) Carbonic anhydrase
precursor_groups_5453 240.36 +- 39.78 11 0 11 11 0.01 +- 0.00 11 4

TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
precursor_groups_31031 268.55 +- 266.44 3 0 0 0 0.06 +- 0.12 3 5

TIGR03620 (3/3) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF12802 (3/3) MarR family
PF07859 (3/3) alpha/beta hydrolase fold
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_5454 257.28 +- 277.71 3 0 2 0 0.02 +- 0.02 3 3

PF02894 (2/3) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (2/3) alpha/beta hydrolase fold
precursor_groups_76737 453.84 +- 326.16 2 0 0 0 0.03 +- 0.10 2 15

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF17866 (2/2) AAA lid domain
PF13229 (2/2) Right handed beta helix region
PF13191 (2/2) AAA ATPase domain
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF01580 (2/2) FtsK/SpoIIIE family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_43313 691.01 +- 84.49 3 0 3 0 0.07 +- 0.18 3 17

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/3) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/3) Beta-lactamase superfamily domain
PF12697 (3/3) Alpha/beta hydrolase family
PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/3) ParB-like nuclease domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
precursor_groups_913 60.36 +- 8.06 2 0 1 0 0.16 +- 0.27 2 5

PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF13499 (1/2) EF-hand domain pair
PF05425 (1/2) Copper resistance protein D
PF01522 (1/2) Polysaccharide deacetylase
precursor_groups_43317 208.61 +- 126.14 3 0 3 0 0.05 +- 0.09 3 6

TIGR03930 (3/3) WXG100 family type VII secretion target
PF06013 (3/3) Proteins of 100 residues with WXG
PF00082 (3/3) Subtilase family
TIGR03921 (2/3) type VII secretion-associated serine protease mycosin
TIGR03919 (2/3) type VII secretion protein EccB
PF05108 (2/3) Type VII secretion system ESX-1, transport TM domain B
precursor_groups_56304 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00534 (2/2) Glycosyl transferases group 1
precursor_groups_85472 390.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_22741 3540.14 +- 3032.69 3 0 1 3 0.01 +- 0.03 3 26

TIGR01762 (3/3) chlorinating enzyme
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14805 (3/3) Tetrahydrodipicolinate N-succinyltransferase N-terminal
PF14602 (3/3) Hexapeptide repeat of succinyl-transferase
PF13535 (3/3) ATP-grasp domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF05199 (3/3) GMC oxidoreductase
PF04909 (3/3) Amidohydrolase
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00733 (3/3) Asparagine synthase
PF00732 (3/3) GMC oxidoreductase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00278 (3/3) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00155 (3/3) Aminotransferase class I and II
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF18130 (2/3) ATP-grasp N-terminal domain
PF13537 (2/3) Glutamine amidotransferase domain
PF05960 (2/3) Bacterial protein of unknown function (DUF885)
precursor_groups_71395 15.00 +- 0.92 2 0 0 0 0.13 +- 0.01 2 5

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00455 (2/2) DeoR C terminal sensor domain
precursor_groups_918 131.38 +- 135.09 49 0 16 49 0.06 +- 0.16 49 4

PF04055 (49/49) Radical SAM superfamily
PF07690 (47/49) Major Facilitator Superfamily
PF02897 (46/49) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (46/49) Prolyl oligopeptidase family
precursor_groups_61915 488.91 +- 421.09 2 0 0 0 0.06 +- 0.23 2 12

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11136 (2/2) Protein of unknown function (DUF2889)
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00384 (2/2) Molybdopterin oxidoreductase
PF00106 (2/2) short chain dehydrogenase
TIGR01915 (1/2) NADPH-dependent F420 reductase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
precursor_groups_56411 24.96 +- 11.46 2 0 0 0 0.11 +- 0.11 2 3

PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF00877 (2/2) NlpC/P60 family
PF00535 (1/2) Glycosyl transferase family 2
precursor_groups_56410 77.83 +- 6.99 2 0 2 0 0.21 +- 0.32 2 22

TIGR01686 (2/2) FkbH domain
PF18605 (2/2) Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF11700 (2/2) Vacuole effluxer Atg22 like
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF03466 (2/2) LysR substrate binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_67591 424.72 +- 114.31 2 0 2 0 0.02 +- 0.01 2 12

PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07690 (2/2) Major Facilitator Superfamily
PF03060 (2/2) Nitronate monooxygenase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_78374 304.77 +- 44.77 2 0 0 0 0.02 +- 0.01 2 6

PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01935 (2/2) Helicase HerA, central domain
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_groups_18409 159.99 +- 133.11 4 0 0 0 0.08 +- 0.18 4 4

TIGR04267 (4/4) HEXXH motif domain
PF14016 (4/4) Protein of unknown function (DUF4232)
PF08962 (4/4) Domain of unknown function (DUF1876)
PF00156 (4/4) Phosphoribosyl transferase domain
precursor_groups_14993 127.88 +- 75.05 7 0 7 7 0.06 +- 0.05 7 6

PF13471 (7/7) Transglutaminase-like superfamily
PF05402 (7/7) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (7/7) Asparagine synthase
PF00664 (7/7) ABC transporter transmembrane region
PF00005 (7/7) ABC transporter
PF00196 (6/7) Bacterial regulatory proteins, luxR family
precursor_groups_35657 218.58 +- 5.07 3 0 3 0 0.02 +- 0.01 3 8

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13577 (3/3) SnoaL-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06902 (3/3) Divergent 4Fe-4S mono-cluster
PF04673 (3/3) Polyketide synthesis cyclase
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450
precursor_groups_19860 701.00 +- 339.95 3 0 0 0 0.04 +- 0.01 3 13

PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (3/3) Fibronectin type III-like domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF02055 (3/3) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (3/3) IPT/TIG domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00754 (3/3) F5/8 type C domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_26684 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_groups_19869 11.78 +- 2.49 3 0 0 0 0.17 +- 0.25 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (3/3) Cellulose binding domain
precursor_groups_40889 372.71 +- 103.15 3 0 0 0 0.08 +- 0.06 3 10

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
precursor_groups_42571 182.55 +- 49.54 3 0 3 0 0.07 +- 0.09 3 10

PF16864 (3/3) Dimerisation domain
PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF04672 (3/3) S-adenosyl methyltransferase
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00891 (3/3) O-methyltransferase domain
PF00664 (3/3) ABC transporter transmembrane region
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
precursor_groups_12802 121.29 +- 102.40 7 0 0 0 0.04 +- 0.05 7 4

PF02838 (7/7) Glycosyl hydrolase family 20, domain 2
PF01120 (7/7) Alpha-L-fucosidase
PF00728 (7/7) Glycosyl hydrolase family 20, catalytic domain
PF00144 (7/7) Beta-lactamase
precursor_groups_64749 62.86 +- 0.00 2 0 2 0 0.19 +- 0.28 2 8

TIGR03571 (2/2) luciferase-type oxidoreductase, BA3436 family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (2/2) SnoaL-like domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03928 (2/2) Haem-degrading
PF00857 (2/2) Isochorismatase family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_2079 124.61 +- 109.42 3 0 0 0 0.06 +- 0.13 3

No common domains found
precursor_groups_40828 34.67 +- 0.00 2 0 2 0 0.06 +- 0.03 2 2

PF03745 (2/2) Domain of unknown function (DUF309)
PF01636 (2/2) Phosphotransferase enzyme family
precursor_groups_38977 78.80 +- 44.78 2 0 2 0 0.20 +- 0.34 2 17

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03061 (2/2) Thioesterase superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF02057 (1/2) Glycosyl hydrolase family 59
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_26971 97.88 +- 0.75 2 0 0 2 0.24 +- 0.31 2 12

TIGR03699 (2/2) dehypoxanthine futalosine cyclase
TIGR01934 (2/2) ubiquinone/menaquinone biosynthesis methyltransferase
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF13240 (2/2) zinc-ribbon domain
PF07811 (2/2) TadE-like protein
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF01478 (2/2) Type IV leader peptidase family
PF01209 (2/2) ubiE/COQ5 methyltransferase family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_groups_10339 92.06 +- 16.78 4 0 4 0 0.18 +- 0.25 4 9

TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/4) HlyD family secretion protein
PF13424 (4/4) Tetratricopeptide repeat
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00348 (4/4) Polyprenyl synthetase
PF00005 (4/4) ABC transporter
PF07719 (2/4) Tetratricopeptide repeat
precursor_groups_2070 93.34 +- 74.16 3 0 0 0 0.20 +- 0.29 3 10

PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
TIGR03177 (2/3) Flp pilus assembly protein CpaB
PF16976 (2/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/3) AAA domain
PF07811 (2/3) TadE-like protein
PF00437 (2/3) Type II/IV secretion system protein
precursor_groups_2073 354.53 +- 457.18 3 0 0 0 0.08 +- 0.09 3

No common domains found
precursor_groups_14303 257.25 +- 146.57 5 0 0 0 0.06 +- 0.10 5 9

TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (5/5) Tetracyclin repressor-like, C-terminal domain
PF14224 (5/5) Domain of unknown function (DUF4331)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF00925 (5/5) GTP cyclohydrolase II
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00107 (5/5) Zinc-binding dehydrogenase
PF00082 (3/5) Subtilase family
precursor_groups_30490 382.58 +- 240.92 4 0 4 0 0.02 +- 0.02 4 4

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF02441 (4/4) Flavoprotein
PF00005 (4/4) ABC transporter
precursor_groups_79589 16.67 +- 5.46 2 0 0 0 0.18 +- 0.01 2 5

TIGR03802 (2/2) aspartate-alanine antiporter
TIGR03801 (2/2) aspartate 4-decarboxylase
PF06826 (2/2) Predicted Permease Membrane Region
PF02080 (2/2) TrkA-C domain
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_74067 580.50 +- 193.50 2 0 2 0 0.01 +- 0.00 2 6

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
precursor_groups_1050 128.86 +- 78.32 15 0 15 15 0.06 +- 0.11 15 2

PF13575 (15/15) Domain of unknown function (DUF4135)
PF05147 (15/15) Lanthionine synthetase C-like protein
precursor_groups_12807 321.97 +- 199.60 8 0 5 0 0.02 +- 0.04 8 4

PF02515 (8/8) CoA-transferase family III
PF00465 (8/8) Iron-containing alcohol dehydrogenase
PF00248 (8/8) Aldo/keto reductase family
PF00067 (8/8) Cytochrome P450
precursor_groups_18313 321.88 +- 288.71 5 0 4 5 0.03 +- 0.11 5 5

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF05114 (4/5) Protein of unknown function (DUF692)
PF08007 (3/5) Cupin superfamily protein
precursor_groups_34125 645.32 +- 489.88 2 0 0 0 0.07 +- 0.21 2 11

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
precursor_groups_25791 685.57 +- 53.59 4 0 3 0 0.07 +- 0.22 4 19

TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (4/4) ATP-grasp domain
PF13535 (4/4) ATP-grasp domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF13115 (4/4) YtkA-like
PF04389 (4/4) Peptidase family M28
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01676 (4/4) Metalloenzyme superfamily
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00664 (4/4) ABC transporter transmembrane region
PF00403 (4/4) Heavy-metal-associated domain
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (4/4) Aminotransferase class I and II
PF00122 (4/4) E1-E2 ATPase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00005 (4/4) ABC transporter
PF02222 (2/4) ATP-grasp domain
precursor_groups_17988 108.16 +- 66.81 3 0 0 0 0.06 +- 0.08 3 2

PF02515 (3/3) CoA-transferase family III
PF01636 (3/3) Phosphotransferase enzyme family
precursor_groups_82563 85.65 +- 22.12 2 0 2 0 0.15 +- 0.11 2 13

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF08281 (2/2) Sigma-70, region 4
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF04542 (2/2) Sigma-70 region 2
PF04188 (2/2) Mannosyltransferase (PIG-V)
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00455 (2/2) DeoR C terminal sensor domain
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
precursor_groups_6826 186.15 +- 57.91 3 0 0 0 0.05 +- 0.12 3 3

PF07859 (2/3) alpha/beta hydrolase fold
PF07690 (2/3) Major Facilitator Superfamily
PF01494 (2/3) FAD binding domain
precursor_groups_50127 595.22 +- 87.28 2 0 0 0 0.03 +- 0.03 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_2793 328.45 +- 257.44 4 0 0 0 0.03 +- 0.02 4 16

TIGR03804 (4/4) parallel beta-helix repeat
TIGR03641 (4/4) CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP
TIGR02593 (4/4) CRISPR-associated protein Cas5
TIGR02585 (4/4) CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP
TIGR01877 (4/4) CRISPR-associated endoribonuclease Cas6
TIGR01596 (4/4) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (4/4) CRISPR-associated helicase Cas3
TIGR01573 (4/4) CRISPR-associated endonuclease Cas2
PF18019 (4/4) HD domain
PF13229 (4/4) Right handed beta helix region
PF09827 (4/4) CRISPR associated protein Cas2
PF09704 (4/4) CRISPR-associated protein (Cas_Cas5)
PF01930 (4/4) Domain of unknown function DUF83
PF01881 (4/4) CRISPR associated protein Cas6
PF01867 (4/4) CRISPR associated protein Cas1
PF00270 (4/4) DEAD/DEAH box helicase
precursor_groups_43953 84.76 +- 7.49 3 0 0 0 0.14 +- 0.19 3 12

TIGR01187 (3/3) polyamine ABC transporter, ATP-binding protein
TIGR00212 (3/3) hydroxymethylbilane synthase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF03900 (3/3) Porphobilinogen deaminase, C-terminal domain
PF01593 (3/3) Flavin containing amine oxidoreductase
PF01379 (3/3) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_groups_74262 18.84 +- 0.27 2 0 1 0 0.21 +- 0.32 2 5

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF03060 (2/2) Nitronate monooxygenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02467 (2/2) Transcription factor WhiB
precursor_groups_76511 40.60 +- 11.40 2 0 0 0 0.09 +- 0.07 2 5

PF13460 (2/2) NAD(P)H-binding
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00561 (2/2) alpha/beta hydrolase fold
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_groups_18791 118.82 +- 83.09 2 0 1 0 0.10 +- 0.24 2 6

PF13649 (2/2) Methyltransferase domain
PF13349 (2/2) Putative adhesin
PF07592 (2/2) Rhodopirellula transposase DDE domain
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_22347 353.86 +- 232.14 3 0 0 0 0.06 +- 0.10 3 3

PF11338 (3/3) Protein of unknown function (DUF3140)
PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF00857 (3/3) Isochorismatase family
precursor_groups_2105 815.16 +- 1026.38 6 0 4 0 0.06 +- 0.21 6 13

TIGR01733 (4/6) amino acid adenylation domain
PF13193 (4/6) AMP-binding enzyme C-terminal domain
PF00975 (4/6) Thioesterase domain
PF00668 (4/6) Condensation domain
PF00550 (4/6) Phosphopantetheine attachment site
PF00501 (4/6) AMP-binding enzyme
PF16197 (3/6) Ketoacyl-synthetase C-terminal extension
PF05995 (3/6) Cysteine dioxygenase type I
PF03621 (3/6) MbtH-like protein
PF02801 (3/6) Beta-ketoacyl synthase, C-terminal domain
PF02668 (3/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (3/6) Acyl transferase domain
PF00109 (3/6) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_6316 307.12 +- 213.54 11 0 3 0 0.11 +- 0.21 11 14

TIGR00711 (11/11) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (11/11) Major Facilitator Superfamily
PF01814 (11/11) Hemerythrin HHE cation binding domain
TIGR00928 (10/11) adenylosuccinate lyase
PF13673 (10/11) Acetyltransferase (GNAT) domain
PF01425 (10/11) Amidase
PF00486 (10/11) Transcriptional regulatory protein, C terminal
PF00206 (10/11) Lyase
PF00120 (10/11) Glutamine synthetase, catalytic domain
PF00072 (10/11) Response regulator receiver domain
PF12800 (9/11) 4Fe-4S binding domain
PF13460 (7/11) NAD(P)H-binding
PF01494 (7/11) FAD binding domain
PF00561 (7/11) alpha/beta hydrolase fold
precursor_groups_21256 21.44 +- 5.42 5 0 0 0 0.15 +- 0.06 5 5

TIGR02089 (5/5) tartrate dehydrogenase
PF03466 (5/5) LysR substrate binding domain
PF00202 (5/5) Aminotransferase class-III
PF00180 (5/5) Isocitrate/isopropylmalate dehydrogenase
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_2103 51.59 +- 30.51 2 0 0 0 0.17 +- 0.30 2 13

TIGR03535 (1/2) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
PF17940 (1/2) Tetracyclin repressor-like, C-terminal domain
PF14789 (1/2) Tetrahydrodipicolinate N-succinyltransferase middle
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF14019 (1/2) Protein of unknown function (DUF4235)
PF13641 (1/2) Glycosyltransferase like family 2
PF12277 (1/2) Protein of unknown function (DUF3618)
PF07332 (1/2) Putative Actinobacterial Holin-X, holin superfamily III
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01757 (1/2) Acyltransferase family
PF01522 (1/2) Polysaccharide deacetylase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00149 (1/2) Calcineurin-like phosphoesterase
precursor_groups_27927 280.00 +- 36.96 4 0 0 0 0.01 +- 0.00 4 4

PF13404 (4/4) AsnC-type helix-turn-helix domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF01037 (4/4) Lrp/AsnC ligand binding domain
PF00501 (4/4) AMP-binding enzyme
precursor_groups_2109 158.66 +- 45.79 2 0 0 0 0.06 +- 0.04 2 8

TIGR01821 (2/2) 5-aminolevulinic acid synthase
PF07690 (2/2) Major Facilitator Superfamily
PF06224 (2/2) Winged helix DNA-binding domain
PF03466 (2/2) LysR substrate binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00155 (2/2) Aminotransferase class I and II
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_12020 26.03 +- 8.37 2 0 0 0 0.23 +- 0.28 2 11

TIGR00045 (2/2) glycerate kinase
PF07690 (2/2) Major Facilitator Superfamily
PF02595 (2/2) Glycerate kinase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (2/2) Sodium:sulfate symporter transmembrane region
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00144 (2/2) Beta-lactamase
PF00072 (2/2) Response regulator receiver domain
PF12867 (1/2) DinB superfamily
precursor_groups_38207 556.00 +- 402.80 3 0 0 0 0.03 +- 0.06 3 12

TIGR01409 (3/3) Tat (twin-arginine translocation) pathway signal sequence
PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (3/3) Major Facilitator Superfamily
PF04616 (3/3) Glycosyl hydrolases family 43
PF02449 (3/3) Beta-galactosidase
PF00801 (3/3) PKD domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00005 (3/3) ABC transporter
precursor_groups_6958 21.51 +- 9.89 9 0 3 0 0.14 +- 0.11 9 5

PF04324 (9/9) BFD-like [2Fe-2S] binding domain
PF02782 (9/9) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (9/9) FAD dependent oxidoreductase
PF00370 (9/9) FGGY family of carbohydrate kinases, N-terminal domain
PF07992 (7/9) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_83733 4608.81 +- 2021.19 2 0 2 0 0.02 +- 0.03 2 16

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain
precursor_groups_6267 78.21 +- 33.74 4 0 2 0 0.10 +- 0.13 4 15

PF13520 (3/4) Amino acid permease
TIGR02353 (2/4) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (2/4) amino acid adenylation domain
TIGR01350 (2/4) dihydrolipoyl dehydrogenase
PF17900 (2/4) Peptidase M1 N-terminal domain
PF13578 (2/4) Methyltransferase domain
PF10009 (2/4) Uncharacterized protein conserved in bacteria (DUF2252)
PF09557 (2/4) Domain of unknown function (DUF2382)
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF05239 (2/4) PRC-barrel domain
PF02852 (2/4) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01433 (2/4) Peptidase family M1 domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00132 (2/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_83739 74.07 +- 0.00 2 0 0 0 0.19 +- 0.07 2 5

PF04909 (2/2) Amidohydrolase
PF04199 (2/2) Putative cyclase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_27993 243.67 +- 142.46 4 0 0 0 0.05 +- 0.06 4 5

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (4/4) Major Facilitator Superfamily
PF01553 (4/4) Acyltransferase
PF01148 (4/4) Cytidylyltransferase family
PF01066 (4/4) CDP-alcohol phosphatidyltransferase
precursor_groups_3678 15.71 +- 0.54 2 0 1 0 0.13 +- 0.14 2 5

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00331 (2/2) Glycosyl hydrolase family 10
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_groups_72703 12.19 +- 0.00 2 0 2 0 0.25 +- 0.32 2 4

PF07730 (2/2) Histidine kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
precursor_groups_32897 691.01 +- 84.49 3 0 3 0 0.07 +- 0.18 3 17

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/3) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/3) Beta-lactamase superfamily domain
PF12697 (3/3) Alpha/beta hydrolase family
PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/3) ParB-like nuclease domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
precursor_groups_7579 595.93 +- 375.41 11 0 11 0 0.03 +- 0.10 11 31

TIGR02087 (11/11) 3-isopropylmalate dehydratase, small subunit
TIGR01733 (11/11) amino acid adenylation domain
TIGR00566 (11/11) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (11/11) aminodeoxychorismate synthase, component I
PF16197 (11/11) Ketoacyl-synthetase C-terminal extension
PF14765 (11/11) Polyketide synthase dehydratase
PF13673 (11/11) Acetyltransferase (GNAT) domain
PF13649 (11/11) Methyltransferase domain
PF13480 (11/11) Acetyltransferase (GNAT) domain
PF13193 (11/11) AMP-binding enzyme C-terminal domain
PF08659 (11/11) KR domain
PF07690 (11/11) Major Facilitator Superfamily
PF04715 (11/11) Anthranilate synthase component I, N terminal region
PF02801 (11/11) Beta-ketoacyl synthase, C-terminal domain
PF01817 (11/11) Chorismate mutase type II
PF01474 (11/11) Class-II DAHP synthetase family
PF01063 (11/11) Amino-transferase class IV
PF00850 (11/11) Histone deacetylase domain
PF00698 (11/11) Acyl transferase domain
PF00694 (11/11) Aconitase C-terminal domain
PF00682 (11/11) HMGL-like
PF00668 (11/11) Condensation domain
PF00550 (11/11) Phosphopantetheine attachment site
PF00501 (11/11) AMP-binding enzyme
PF00425 (11/11) chorismate binding enzyme
PF00330 (11/11) Aconitase family (aconitate hydratase)
PF00180 (11/11) Isocitrate/isopropylmalate dehydrogenase
PF00117 (11/11) Glutamine amidotransferase class-I
PF00109 (11/11) Beta-ketoacyl synthase, N-terminal domain
PF05977 (10/11) Transmembrane secretion effector
PF00975 (10/11) Thioesterase domain
precursor_groups_6003 224.28 +- 198.91 3 0 1 0 0.04 +- 0.05 3 4

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF02638 (3/3) Glycosyl hydrolase-like 10
PF01471 (3/3) Putative peptidoglycan binding domain
precursor_groups_1908 177.38 +- 80.62 2 0 1 0 0.01 +- 0.01 2 5

PF16952 (1/2) Glutamine synthetase N-terminal domain
PF04909 (1/2) Amidohydrolase
PF02195 (1/2) ParB-like nuclease domain
PF01494 (1/2) FAD binding domain
PF00120 (1/2) Glutamine synthetase, catalytic domain
precursor_groups_11182 61.30 +- 7.50 2 0 1 0 0.06 +- 0.09 2 8

PF14042 (1/2) Domain of unknown function (DUF4247)
PF13359 (1/2) DDE superfamily endonuclease
PF10936 (1/2) Protein of unknown function DUF2617
PF08241 (1/2) Methyltransferase domain
PF03994 (1/2) Domain of Unknown Function (DUF350)
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01564 (1/2) Spermine/spermidine synthase domain
PF00293 (1/2) NUDIX domain
precursor_groups_42955 263.92 +- 28.11 3 0 0 0 0.07 +- 0.13 3 15

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13468 (3/3) Glyoxalase-like domain
PF13247 (3/3) 4Fe-4S dicluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF04909 (3/3) Amidohydrolase
PF03595 (3/3) Voltage-dependent anion channel
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF01494 (3/3) FAD binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_groups_42402 174.91 +- 6.68 2 0 0 0 0.06 +- 0.05 2 11

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_groups_43421 432.73 +- 22.27 2 0 0 2 0.03 +- 0.04 2 12

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (2/2) Glutamine amidotransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00962 (2/2) Adenosine/AMP deaminase
PF00733 (2/2) Asparagine synthase
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00535 (1/2) Glycosyl transferase family 2
precursor_groups_1907 193.31 +- 107.17 32 0 32 0 0.04 +- 0.02 32 3

PF11991 (32/32) Tryptophan dimethylallyltransferase
PF07690 (32/32) Major Facilitator Superfamily
PF00155 (32/32) Aminotransferase class I and II
precursor_groups_1902 127.43 +- 19.00 3 0 0 3 0.13 +- 0.18 3 9

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF01494 (3/3) FAD binding domain
PF00881 (3/3) Nitroreductase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_groups_64830 32.14 +- 5.91 2 0 0 0 0.10 +- 0.16 2 6

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF05977 (2/2) Transmembrane secretion effector
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00082 (2/2) Subtilase family
precursor_groups_11135 519.99 +- 158.48 8 0 8 0 0.02 +- 0.01 8 13

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (8/8) amino acid adenylation domain
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF02655 (8/8) ATP-grasp domain
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00296 (8/8) Luciferase-like monooxygenase
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_722 120.53 +- 86.43 5 0 0 0 0.07 +- 0.12 5 6

PF03795 (5/5) YCII-related domain
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/5) Sigma-70, region 4
PF06108 (4/5) Protein of unknown function (DUF952)
PF04542 (4/5) Sigma-70 region 2
PF01872 (3/5) RibD C-terminal domain
precursor_groups_81385 2404.29 +- 175.71 2 0 2 0 0.01 +- 0.00 2 5

PF13463 (2/2) Winged helix DNA-binding domain
PF09084 (2/2) NMT1/THI5 like
PF04909 (2/2) Amidohydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_61264 193.50 +- 0.00 2 0 2 0 0.03 +- 0.01 2 5

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_31848 1683.00 +- 123.00 2 0 0 0 0.01 +- 0.00 2 3

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
PF02515 (1/2) CoA-transferase family III
precursor_groups_10660 180.30 +- 87.44 2 0 0 0 0.07 +- 0.14 2 12

PF07730 (2/2) Histidine kinase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF03008 (2/2) Archaea bacterial proteins of unknown function
PF02687 (2/2) FtsX-like permease family
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF13424 (1/2) Tetratricopeptide repeat
PF13176 (1/2) Tetratricopeptide repeat
PF00931 (1/2) NB-ARC domain
precursor_groups_51288 10.22 +- 1.00 2 0 0 0 0.20 +- 0.07 2 2

PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
precursor_groups_35030 215.00 +- 60.81 3 0 3 0 0.01 +- 0.01 3 3

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_45864 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_51283 22.24 +- 1.04 2 0 0 0 0.18 +- 0.12 2 3

PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_66270 292.50 +- 97.50 2 0 2 0 0.01 +- 0.00 2 3

PF03928 (2/2) Haem-degrading
PF03795 (2/2) YCII-related domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_3211 244.20 +- 95.41 23 0 0 0 0.05 +- 0.06 23 6

TIGR03930 (23/23) WXG100 family type VII secretion target
TIGR03921 (23/23) type VII secretion-associated serine protease mycosin
TIGR03919 (23/23) type VII secretion protein EccB
PF06013 (23/23) Proteins of 100 residues with WXG
PF05108 (23/23) Type VII secretion system ESX-1, transport TM domain B
PF00082 (23/23) Subtilase family
precursor_groups_3214 1684.33 +- 867.88 25 0 25 25 0.04 +- 0.06 25 11

TIGR01208 (25/25) glucose-1-phosphate thymidylyltransferase
PF13649 (25/25) Methyltransferase domain
PF05147 (25/25) Lanthionine synthetase C-like protein
PF00535 (25/25) Glycosyl transferase family 2
PF00483 (25/25) Nucleotidyl transferase
PF00465 (25/25) Iron-containing alcohol dehydrogenase
PF00296 (25/25) Luciferase-like monooxygenase
PF00202 (25/25) Aminotransferase class-III
PF00132 (25/25) Bacterial transferase hexapeptide (six repeats)
PF00069 (25/25) Protein kinase domain
PF00005 (25/25) ABC transporter
precursor_groups_54635 28.28 +- 15.05 2 0 0 0 0.17 +- 0.11 2 3

PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF07690 (1/2) Major Facilitator Superfamily
PF04185 (1/2) Phosphoesterase family
precursor_groups_52031 37.05 +- 2.65 2 0 0 0 0.11 +- 0.13 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
PF00082 (2/2) Subtilase family
precursor_groups_54637 69.96 +- 24.43 2 0 0 2 0.05 +- 0.09 2 11

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain
precursor_groups_12804 175.33 +- 70.33 8 0 0 0 0.11 +- 0.11 8 17

TIGR01409 (8/8) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (8/8) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (8/8) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (8/8) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (8/8) Alpha galactosidase A
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13378 (8/8) Enolase C-terminal domain-like
PF08450 (8/8) SMP-30/Gluconolactonase/LRE-like region
PF07729 (8/8) FCD domain
PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (8/8) Melibiase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01081 (8/8) KDPG and KHG aldolase
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
precursor_groups_7754 126.36 +- 82.01 6 0 6 0 0.11 +- 0.21 6 8

TIGR01733 (6/6) amino acid adenylation domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF07690 (6/6) Major Facilitator Superfamily
PF03621 (6/6) MbtH-like protein
PF00975 (6/6) Thioesterase domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
precursor_groups_26208 416.77 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04909 (2/2) Amidohydrolase
PF00501 (2/2) AMP-binding enzyme
precursor_groups_11599 20.26 +- 1.65 2 0 0 0 0.15 +- 0.23 2 5

PF13377 (2/2) Periplasmic binding protein-like domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (2/2) Cellulose binding domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_7376 49.55 +- 24.60 10 0 0 0 0.05 +- 0.03 10 3

PF00150 (10/10) Cellulase (glycosyl hydrolase family 5)
PF09130 (9/10) Domain of unknown function (DUF1932)
PF03446 (7/10) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_44025 395.42 +- 37.92 2 0 2 0 0.05 +- 0.03 2 18

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12849 (2/2) PBP superfamily domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF01022 (1/2) Bacterial regulatory protein, arsR family
precursor_groups_44795 347.40 +- 221.09 3 0 0 0 0.05 +- 0.18 3 9

TIGR02170 (3/3) thymidylate synthase, flavin-dependent
TIGR00730 (3/3) TIGR00730 family protein
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (3/3) ATP-grasp domain
PF03641 (3/3) Possible lysine decarboxylase
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02511 (3/3) Thymidylate synthase complementing protein
PF00106 (3/3) short chain dehydrogenase
precursor_groups_59071 360.33 +- 159.67 2 0 0 0 0.01 +- 0.02 2 6

PF13560 (2/2) Helix-turn-helix domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF09851 (2/2) Short C-terminal domain
PF07731 (2/2) Multicopper oxidase
PF04972 (2/2) BON domain
PF00571 (2/2) CBS domain
precursor_groups_72065 520.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03551 (2/2) Transcriptional regulator PadR-like family
PF03070 (2/2) TENA/THI-4/PQQC family
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_groups_4951 11.79 +- 3.07 14 0 0 0 0.18 +- 0.37 14 4

TIGR00737 (14/14) putative TIM-barrel protein, nifR3 family
PF06386 (14/14) Gas vesicle synthesis protein GvpL/GvpF
PF03364 (14/14) Polyketide cyclase / dehydrase and lipid transport
PF01207 (14/14) Dihydrouridine synthase (Dus)
precursor_groups_4954 687.48 +- 741.12 14 0 10 3 0.01 +- 0.01 14 4

PF04324 (14/14) BFD-like [2Fe-2S] binding domain
PF00334 (13/14) Nucleoside diphosphate kinase
PF00551 (11/14) Formyl transferase
PF00202 (11/14) Aminotransferase class-III
precursor_groups_20902 109.55 +- 102.16 5 0 4 0 0.05 +- 0.02 5 12

PF13640 (5/5) 2OG-Fe(II) oxygenase superfamily
PF00501 (5/5) AMP-binding enzyme
TIGR01746 (4/5) thioester reductase domain
TIGR01733 (4/5) amino acid adenylation domain
PF18130 (4/5) ATP-grasp N-terminal domain
PF13535 (4/5) ATP-grasp domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF07993 (4/5) Male sterility protein
PF05118 (4/5) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (4/5) Condensation domain
PF00550 (4/5) Phosphopantetheine attachment site
PF00106 (4/5) short chain dehydrogenase
precursor_groups_60437 422.57 +- 201.43 2 0 2 0 0.02 +- 0.02 2 9

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF08659 (2/2) KR domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_70772 2338.97 +- 241.03 2 0 0 0 0.01 +- 0.02 2 10

PF12680 (2/2) SnoaL-like domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00005 (2/2) ABC transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01494 (1/2) FAD binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_54039 16.01 +- 2.56 2 0 0 0 0.19 +- 0.29 2 7

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF04149 (2/2) Domain of unknown function (DUF397)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00754 (2/2) F5/8 type C domain
precursor_groups_3857 17.50 +- 0.34 5 0 0 0 0.17 +- 0.23 5 4

PF13722 (5/5) 5TM C-terminal transporter carbon starvation CstA
PF04328 (5/5) Selenoprotein, putative
PF02554 (5/5) Carbon starvation protein CstA
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_groups_50244 212.87 +- 45.13 2 0 0 0 0.02 +- 0.03 2 11

TIGR00773 (2/2) Na+/H+ antiporter NhaA
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13462 (2/2) Thioredoxin
PF12831 (2/2) FAD dependent oxidoreductase
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF06965 (2/2) Na+/H+ antiporter 1
PF02515 (2/2) CoA-transferase family III
PF01381 (2/2) Helix-turn-helix
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_3859 12.28 +- 2.75 7 0 0 0 0.17 +- 0.11 7 6

PF14542 (7/7) GCN5-related N-acetyl-transferase
PF08220 (7/7) DeoR-like helix-turn-helix domain
PF02782 (7/7) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (7/7) DeoR C terminal sensor domain
PF00370 (7/7) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (7/7) Histidine phosphatase superfamily (branch 1)
precursor_groups_36655 40.84 +- 20.91 3 0 0 0 0.09 +- 0.11 3 6

TIGR01552 (3/3) prevent-host-death family protein
PF12277 (3/3) Protein of unknown function (DUF3618)
PF07332 (3/3) Putative Actinobacterial Holin-X, holin superfamily III
PF02604 (3/3) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01850 (3/3) PIN domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_36654 1314.09 +- 375.91 2 0 0 0 0.01 +- 0.00 2 11

PF12399 (2/2) Branched-chain amino acid ATP-binding cassette transporter
PF04909 (2/2) Amidohydrolase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00005 (2/2) ABC transporter
PF13458 (1/2) Periplasmic binding protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (1/2) CoA-transferase family III
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00171 (1/2) Aldehyde dehydrogenase family
precursor_groups_11916 54.13 +- 9.39 6 0 0 6 0.18 +- 0.34 6 12

TIGR04276 (6/6) FxsC C-terminal domain
TIGR04269 (6/6) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (6/6) HEXXH motif domain
PF13676 (6/6) TIR domain
PF13424 (6/6) Tetratricopeptide repeat
PF13407 (6/6) Periplasmic binding protein domain
PF13374 (6/6) Tetratricopeptide repeat
PF04055 (6/6) Radical SAM superfamily
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF02522 (6/6) Aminoglycoside 3-N-acetyltransferase
PF00931 (6/6) NB-ARC domain
PF00005 (6/6) ABC transporter
precursor_groups_34870 698.29 +- 358.70 3 0 0 0 0.02 +- 0.03 3 7

PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF03704 (3/3) Bacterial transcriptional activator domain
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_groups_23015 30.48 +- 1.52 4 0 0 0 0.13 +- 0.14 4 7

PF14031 (4/4) Putative serine dehydratase domain
PF13309 (4/4) HTH domain
PF08348 (4/4) YheO-like PAS domain
PF07077 (4/4) Protein of unknown function (DUF1345)
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01168 (4/4) Alanine racemase, N-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_1239 186.59 +- 153.00 13 0 0 0 0.02 +- 0.02 13 4

PF13649 (13/13) Methyltransferase domain
PF13280 (13/13) WYL domain
PF00300 (13/13) Histidine phosphatase superfamily (branch 1)
PF08279 (11/13) HTH domain
precursor_groups_20699 85.33 +- 49.96 5 0 5 0 0.11 +- 0.19 5 8

PF12704 (5/5) MacB-like periplasmic core domain
PF02687 (5/5) FtsX-like permease family
PF02153 (5/5) Prephenate dehydrogenase
PF01471 (5/5) Putative peptidoglycan binding domain
PF01243 (5/5) Pyridoxamine 5'-phosphate oxidase
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
TIGR03618 (4/5) PPOX class probable F420-dependent enzyme
precursor_groups_26335 319.40 +- 14.24 4 0 0 0 0.01 +- 0.00 4 6

PF07690 (4/4) Major Facilitator Superfamily
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00899 (4/4) ThiF family
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_11820 27.10 +- 9.02 3 0 3 0 0.19 +- 0.30 3 8

PF13410 (3/3) Glutathione S-transferase, C-terminal domain
PF13409 (3/3) Glutathione S-transferase, N-terminal domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF03422 (3/3) Carbohydrate binding module (family 6)
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00722 (3/3) Glycosyl hydrolases family 16
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF13230 (2/3) Glutamine amidotransferases class-II
precursor_groups_27130 28.89 +- 0.00 2 0 2 0 0.07 +- 0.04 2 4

PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01565 (2/2) FAD binding domain
precursor_groups_15344 65.82 +- 0.00 2 0 0 0 0.15 +- 0.17 2 9

TIGR03723 (2/2) tRNA threonylcarbamoyl adenosine modification protein TsaD
TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02272 (2/2) DHHA1 domain
PF01475 (2/2) Ferric uptake regulator family
PF01411 (2/2) tRNA synthetases class II (A)
PF00814 (2/2) Glycoprotease family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_7196 16.96 +- 1.51 7 0 7 0 0.17 +- 0.19 7 7

PF17765 (7/7) MmyB-like transcription regulator ligand binding domain
PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF13560 (7/7) Helix-turn-helix domain
PF01243 (7/7) Pyridoxamine 5'-phosphate oxidase
PF02797 (6/7) Chalcone and stilbene synthases, C-terminal domain
PF00195 (6/7) Chalcone and stilbene synthases, N-terminal domain
PF00067 (6/7) Cytochrome P450
precursor_groups_69072 234.51 +- 98.07 2 0 2 0 0.08 +- 0.05 2 17

TIGR03494 (2/2) salicylate synthase
TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_44246 631.53 +- 248.09 3 0 3 0 0.02 +- 0.01 3 9

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06259 (3/3) Alpha/beta hydrolase
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_groups_77002 94.50 +- 34.50 2 0 0 0 0.04 +- 0.04 2 6

PF13492 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00005 (2/2) ABC transporter
precursor_groups_75898 426.24 +- 257.68 2 0 2 0 0.05 +- 0.19 2 17

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13460 (2/2) NAD(P)H-binding
PF13454 (2/2) FAD-NAD(P)-binding
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF07690 (2/2) Major Facilitator Superfamily
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR01796 (1/2) chorismate mutase
TIGR01358 (1/2) 3-deoxy-7-phosphoheptulonate synthase
PF07736 (1/2) Chorismate mutase type I
PF02153 (1/2) Prephenate dehydrogenase
PF01474 (1/2) Class-II DAHP synthetase family
precursor_groups_48157 307.65 +- 79.35 2 0 0 0 0.06 +- 0.06 2 9

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14494 (2/2) Domain of unknown function (DUF4436)
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04371 (2/2) Porphyromonas-type peptidyl-arginine deiminase
PF01590 (2/2) GAF domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_4407 92.80 +- 28.43 4 0 0 0 0.19 +- 0.30 4 11

PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
TIGR03177 (3/4) Flp pilus assembly protein CpaB
PF16976 (3/4) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/4) AAA domain
PF07811 (3/4) TadE-like protein
PF07730 (3/4) Histidine kinase
PF00691 (3/4) OmpA family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
PF08666 (2/4) SAF domain
precursor_groups_1697 76.32 +- 102.71 12 0 0 0 0.10 +- 0.23 12 4

TIGR04267 (12/12) HEXXH motif domain
PF14016 (10/12) Protein of unknown function (DUF4232)
PF08962 (10/12) Domain of unknown function (DUF1876)
PF00156 (10/12) Phosphoribosyl transferase domain
precursor_groups_1690 749.97 +- 986.36 40 3 37 37 0.05 +- 0.16 37 8

PF03412 (38/40) Peptidase C39 family
PF00664 (38/40) ABC transporter transmembrane region
PF00005 (38/40) ABC transporter
TIGR03897 (37/40) type 2 lantibiotic biosynthesis protein LanM
PF13575 (37/40) Domain of unknown function (DUF4135)
PF05147 (37/40) Lanthionine synthetase C-like protein
PF14867 (35/40) Lantibiotic alpha
PF00296 (29/40) Luciferase-like monooxygenase
precursor_groups_9850 12.36 +- 0.48 7 0 0 0 0.24 +- 0.38 7 5

TIGR01549 (7/7) HAD hydrolase, family IA, variant 1
PF17197 (7/7) Domain of unknown function (DUF5134)
PF01569 (7/7) PAP2 superfamily
PF01435 (7/7) Peptidase family M48
PF00702 (7/7) haloacid dehalogenase-like hydrolase
precursor_groups_20470 812.16 +- 80.91 2 0 2 0 0.02 +- 0.04 2 10

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03412 (2/2) Peptidase C39 family
PF01636 (2/2) Phosphotransferase enzyme family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_29661 709.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 8

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF17132 (2/2) alpha-L-rhamnosidase
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02057 (2/2) Glycosyl hydrolase family 59
precursor_groups_10081 323.50 +- 63.50 2 0 0 0 0.02 +- 0.01 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00293 (2/2) NUDIX domain
precursor_groups_46664 4088.23 +- 3977.66 2 0 0 0 0.01 +- 0.01 2 19

PF13377 (1/2) Periplasmic binding protein-like domain
PF12697 (1/2) Alpha/beta hydrolase family
PF12006 (1/2) Protein of unknown function (DUF3500)
PF10282 (1/2) Lactonase, 7-bladed beta-propeller
PF09084 (1/2) NMT1/THI5 like
PF07729 (1/2) FCD domain
PF06240 (1/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF04909 (1/2) Amidohydrolase
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02219 (1/2) Methylenetetrahydrofolate reductase
PF01571 (1/2) Aminomethyltransferase folate-binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00135 (1/2) Carboxylesterase family
PF00005 (1/2) ABC transporter
precursor_groups_80705 10.87 +- 0.95 2 0 0 0 0.19 +- 0.05 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_59812 417.11 +- 145.80 2 0 0 0 0.02 +- 0.02 2 5

PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF00857 (2/2) Isochorismatase family
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_37654 155.71 +- 58.32 3 0 0 0 0.04 +- 0.04 3 8

PF07690 (3/3) Major Facilitator Superfamily
PF01596 (3/3) O-methyltransferase
PF01402 (3/3) Ribbon-helix-helix protein, copG family
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00072 (3/3) Response regulator receiver domain
TIGR00027 (2/3) methyltransferase, TIGR00027 family
PF04072 (2/3) Leucine carboxyl methyltransferase
precursor_groups_83541 137.83 +- 64.11 2 0 0 0 0.12 +- 0.10 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13523 (2/2) Acetyltransferase (GNAT) domain
PF06172 (2/2) Cupin superfamily (DUF985)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF01804 (2/2) Penicillin amidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_848 56.04 +- 29.53 58 0 0 0 0.15 +- 0.17 58 6

TIGR00996 (58/58) virulence factor Mce family protein
PF11887 (58/58) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (58/58) MlaD protein
PF02405 (58/58) Permease MlaE
PF00005 (58/58) ABC transporter
PF13406 (50/58) Transglycosylase SLT domain
precursor_groups_50390 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_54038 145.35 +- 20.51 2 0 0 0 0.06 +- 0.10 2 16

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13466 (2/2) STAS domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00108 (2/2) Thiolase, N-terminal domain
precursor_groups_8510 277.25 +- 92.05 5 0 2 4 0.01 +- 0.01 5 4

PF07690 (4/5) Major Facilitator Superfamily
PF04055 (4/5) Radical SAM superfamily
PF02897 (4/5) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (4/5) Prolyl oligopeptidase family
precursor_groups_50645 117.28 +- 1.18 2 0 0 0 0.08 +- 0.03 2 5

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_21504 133.90 +- 28.60 2 0 0 0 0.06 +- 0.07 2 4

PF13309 (2/2) HTH domain
PF08348 (2/2) YheO-like PAS domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_41140 87.56 +- 21.14 3 0 0 0 0.04 +- 0.01 3 6

TIGR03356 (3/3) beta-galactosidase
PF08329 (3/3) Chitinase A, N-terminal domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00376 (3/3) MerR family regulatory protein
PF00331 (3/3) Glycosyl hydrolase family 10
PF00232 (3/3) Glycosyl hydrolase family 1
precursor_groups_9354 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_41147 200.11 +- 58.80 3 0 0 0 0.04 +- 0.03 3 12

TIGR01167 (3/3) LPXTG cell wall anchor domain
PF18130 (3/3) ATP-grasp N-terminal domain
PF17802 (3/3) Prealbumin-like fold domain
PF16259 (3/3) Domain of unknown function (DUF4913)
PF13535 (3/3) ATP-grasp domain
PF12307 (3/3) Protein of unknown function (DUF3631)
PF08239 (3/3) Bacterial SH3 domain
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF02899 (3/3) Phage integrase, N-terminal SAM-like domain
PF01638 (3/3) HxlR-like helix-turn-helix
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_groups_16294 101.95 +- 0.39 3 0 3 3 0.15 +- 0.25 3 13

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF12704 (3/3) MacB-like periplasmic core domain
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF03704 (3/3) Bacterial transcriptional activator domain
PF02687 (3/3) FtsX-like permease family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (3/3) ABC-2 type transporter
PF00931 (3/3) NB-ARC domain
PF00881 (3/3) Nitroreductase family
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
precursor_groups_671 416.77 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04909 (2/2) Amidohydrolase
PF00501 (2/2) AMP-binding enzyme
precursor_groups_37092 30.43 +- 1.57 2 0 2 0 0.13 +- 0.13 2 7

PF11991 (2/2) Tryptophan dimethylallyltransferase
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (2/2) Beta-eliminating lyase
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_33379 129.47 +- 98.14 3 0 0 0 0.04 +- 0.06 3 1

PF01810 (3/3) LysE type translocator
precursor_groups_39 87.51 +- 72.64 10 0 2 2 0.09 +- 0.16 10

No common domains found
precursor_groups_585 72.12 +- 31.18 3 0 0 0 0.05 +- 0.08 3 5

PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF03575 (2/3) Peptidase family S51
PF02852 (2/3) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
precursor_groups_37891 329.15 +- 57.85 2 0 2 0 0.01 +- 0.02 2 9

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
TIGR03930 (1/2) WXG100 family type VII secretion target
PF07179 (1/2) SseB protein N-terminal domain
precursor_groups_46790 42.59 +- 22.93 2 0 0 0 0.13 +- 0.23 2 6

PF10011 (2/2) Predicted membrane protein (DUF2254)
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_groups_24021 26.65 +- 9.96 2 0 0 0 0.19 +- 0.35 2 8

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR01550 (2/2) death-on-curing family protein
PF07690 (2/2) Major Facilitator Superfamily
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02661 (2/2) Fic/DOC family
PF00082 (2/2) Subtilase family
PF09339 (1/2) IclR helix-turn-helix domain
PF05362 (1/2) Lon protease (S16) C-terminal proteolytic domain
precursor_groups_31 163.44 +- 93.91 4 0 0 0 0.13 +- 0.17 4 23

TIGR03707 (4/4) polyphosphate kinase 2
PF03976 (4/4) Polyphosphate kinase 2 (PPK2)
PF01384 (4/4) Phosphate transporter family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
TIGR02315 (2/4) phosphonate ABC transporter, ATP-binding protein
TIGR01182 (2/4) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
TIGR01098 (2/4) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (2/4) phosphonate ABC transporter, permease protein PhnE
PF17801 (2/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/4) Alpha galactosidase A
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/4) Enolase C-terminal domain-like
PF12974 (2/4) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF07729 (2/4) FCD domain
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/4) Melibiase
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF01081 (2/4) KDPG and KHG aldolase
PF00392 (2/4) Bacterial regulatory proteins, gntR family
PF00294 (2/4) pfkB family carbohydrate kinase
PF00005 (2/4) ABC transporter
precursor_groups_1347 1323.86 +- 937.25 49 0 7 0 0.01 +- 0.02 49 5

PF00482 (49/49) Type II secretion system (T2SS), protein F
PF07811 (48/49) TadE-like protein
PF00437 (47/49) Type II/IV secretion system protein
PF08666 (46/49) SAF domain
PF01476 (40/49) LysM domain
precursor_groups_33 93.34 +- 88.28 14 0 9 2 0.16 +- 0.23 14 2

PF07690 (12/14) Major Facilitator Superfamily
PF13653 (7/14) Glycerophosphoryl diester phosphodiesterase family
precursor_groups_70676 74.81 +- 28.39 2 0 2 2 0.06 +- 0.04 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_5862 277.35 +- 238.65 2 0 0 0 0.03 +- 0.05 2 2

PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
precursor_groups_49171 86.67 +- 43.33 2 0 0 2 0.05 +- 0.00 2 15

TIGR04046 (2/2) flavin-dependent oxidoreductase, MSMEG_0569 family
TIGR04044 (2/2) MSMEG_0572 family protein
TIGR04043 (2/2) radical SAM protein, MSMEG_0568 family
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04909 (2/2) Amidohydrolase
PF04055 (2/2) Radical SAM superfamily
TIGR04050 (1/2) AIR synthase-related protein, MSMEG_0567 C-terminal family
TIGR04047 (1/2) glycosyltransferase, MSMEG_0565 family
TIGR04045 (1/2) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family
PF13439 (1/2) Glycosyltransferase Family 4
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00534 (1/2) Glycosyl transferases group 1
precursor_groups_10887 157.25 +- 62.23 4 0 2 0 0.07 +- 0.19 4 9

PF13191 (4/4) AAA ATPase domain
PF10502 (4/4) Signal peptidase, peptidase S26
PF07291 (4/4) Methylamine utilisation protein MauE
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
PF02254 (3/4) TrkA-N domain
PF01242 (3/4) 6-pyruvoyl tetrahydropterin synthase
PF00664 (3/4) ABC transporter transmembrane region
PF13181 (2/4) Tetratricopeptide repeat
precursor_groups_9177 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_2151 256.01 +- 202.81 3 0 0 0 0.06 +- 0.13 3 3

PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
precursor_groups_9777 17.97 +- 2.84 6 0 0 0 0.18 +- 0.36 6 9

TIGR00229 (6/6) PAS domain S-box protein
PF13581 (6/6) Histidine kinase-like ATPase domain
PF12840 (6/6) Helix-turn-helix domain
PF08448 (6/6) PAS fold
PF07702 (6/6) UTRA domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00989 (6/6) PAS fold
PF00392 (6/6) Bacterial regulatory proteins, gntR family
precursor_groups_55170 21.74 +- 2.70 2 0 0 0 0.14 +- 0.16 2 5

TIGR03356 (2/2) beta-galactosidase
PF08445 (2/2) FR47-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF06030 (2/2) Bacterial protein of unknown function (DUF916)
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_61672 53.53 +- 30.08 2 0 0 0 0.08 +- 0.10 2 6

PF08241 (2/2) Methyltransferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF11706 (1/2) CGNR zinc finger
PF07336 (1/2) Putative stress-induced transcription regulator
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_45048 53.36 +- 3.25 2 0 0 0 0.11 +- 0.12 2 12

TIGR01660 (2/2) nitrate reductase, beta subunit
TIGR01580 (2/2) nitrate reductase, alpha subunit
TIGR00684 (2/2) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (2/2) respiratory nitrate reductase, gamma subunit
PF14711 (2/2) Respiratory nitrate reductase beta C-terminal
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF02665 (2/2) Nitrate reductase gamma subunit
PF02613 (2/2) Nitrate reductase delta subunit
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_groups_16766 227.53 +- 174.07 3 0 0 0 0.06 +- 0.13 3 4

TIGR01382 (3/3) intracellular protease, PfpI family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03928 (3/3) Haem-degrading
PF01965 (3/3) DJ-1/PfpI family
precursor_groups_122 209.23 +- 232.03 10 0 1 2 0.10 +- 0.19 10 2

PF13560 (6/10) Helix-turn-helix domain
PF04149 (5/10) Domain of unknown function (DUF397)
precursor_groups_57735 281.67 +- 108.33 2 0 1 0 0.01 +- 0.01 2 6

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
PF13535 (2/2) ATP-grasp domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_groups_28047 85.31 +- 12.19 2 0 0 0 0.04 +- 0.02 2 7

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF17831 (1/2) Pyruvate dehydrogenase E1 component middle domain
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00406 (1/2) Adenylate kinase
PF00293 (1/2) NUDIX domain
precursor_groups_2480 94.18 +- 46.75 17 0 14 0 0.11 +- 0.09 17 8

PF13377 (17/17) Periplasmic binding protein-like domain
PF08220 (17/17) DeoR-like helix-turn-helix domain
PF02826 (17/17) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (17/17) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (17/17) Bacterial extracellular solute-binding protein
PF00528 (17/17) Binding-protein-dependent transport system inner membrane component
TIGR01509 (16/17) HAD hydrolase, family IA, variant 3
PF13419 (16/17) Haloacid dehalogenase-like hydrolase
precursor_groups_72043 1305.99 +- 644.01 2 0 2 0 0.02 +- 0.04 2 14

TIGR01733 (2/2) amino acid adenylation domain
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05175 (2/2) Methyltransferase small domain
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00117 (2/2) Glutamine amidotransferase class-I
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_24112 216.50 +- 18.04 2 0 2 0 0.03 +- 0.03 2 8

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12821 (2/2) Threonine/Serine exporter, ThrE
PF12697 (2/2) Alpha/beta hydrolase family
PF06738 (2/2) Putative threonine/serine exporter
PF01527 (2/2) Transposase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_48835 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_63214 88.74 +- 14.46 2 0 0 0 0.02 +- 0.02 2 2

PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_5262 265.06 +- 306.81 8 0 2 0 0.05 +- 0.11 8 2

PF10935 (6/8) Protein of unknown function (DUF2637)
PF00239 (6/8) Resolvase, N terminal domain
precursor_groups_5265 2176.88 +- 2360.36 4 0 4 4 0.01 +- 0.01 4 8

TIGR03897 (4/4) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/4) Lantibiotic alpha
PF13575 (4/4) Domain of unknown function (DUF4135)
PF05147 (4/4) Lanthionine synthetase C-like protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF00296 (3/4) Luciferase-like monooxygenase
precursor_groups_2242 75.71 +- 85.11 4 0 2 0 0.14 +- 0.27 4 1

PF07690 (3/4) Major Facilitator Superfamily
precursor_groups_2243 40.28 +- 10.21 32 0 0 0 0.11 +- 0.10 32 5

TIGR00456 (32/32) arginine--tRNA ligase
PF05746 (32/32) DALR anticodon binding domain
PF03485 (32/32) Arginyl tRNA synthetase N terminal domain
PF00750 (32/32) tRNA synthetases class I (R)
PF00561 (32/32) alpha/beta hydrolase fold
precursor_groups_2240 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_21098 25.67 +- 0.72 3 0 0 0 0.12 +- 0.11 3 5

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07702 (3/3) UTRA domain
PF01872 (3/3) RibD C-terminal domain
PF00535 (3/3) Glycosyl transferase family 2
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_2244 198.78 +- 6.94 5 0 0 0 0.04 +- 0.13 5 16

PF16945 (5/5) Putative lactococcus lactis phage r1t holin
TIGR01558 (4/5) putative phage terminase, small subunit, P27 family
TIGR01554 (4/5) phage major capsid protein, HK97 family
TIGR01543 (4/5) phage prohead protease, HK97 family
TIGR01537 (4/5) phage portal protein, HK97 family
PF13229 (4/5) Right handed beta helix region
PF10145 (4/5) Phage-related minor tail protein
PF05119 (4/5) Phage terminase, small subunit
PF05065 (4/5) Phage capsid family
PF04860 (4/5) Phage portal protein
PF04586 (4/5) Caudovirus prohead serine protease
PF03354 (4/5) Phage Terminase
PF01510 (4/5) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/5) LysM domain
PF01464 (4/5) Transglycosylase SLT domain
PF01381 (4/5) Helix-turn-helix
precursor_groups_2248 99.38 +- 16.84 2 0 0 0 0.10 +- 0.24 2 24

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR02009 (2/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (2/2) Glyoxalase-like domain
PF17866 (2/2) AAA lid domain
PF14436 (2/2) Bacterial EndoU nuclease
PF13560 (2/2) Helix-turn-helix domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF13229 (2/2) Right handed beta helix region
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (2/2) Cupin domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03636 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_39145 78.19 +- 0.44 2 0 0 0 0.10 +- 0.24 2 10

PF17668 (2/2) Acetyltransferase (GNAT) domain
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13530 (2/2) Sterol carrier protein domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12821 (2/2) Threonine/Serine exporter, ThrE
PF09335 (2/2) SNARE associated Golgi protein
PF06738 (2/2) Putative threonine/serine exporter
PF00877 (2/2) NlpC/P60 family
PF00183 (2/2) Hsp90 protein
precursor_groups_13324 30.65 +- 8.98 5 0 0 0 0.14 +- 0.23 5 7

TIGR03696 (5/5) RHS repeat-associated core domain
TIGR01643 (5/5) YD repeat (two copies)
PF13641 (5/5) Glycosyltransferase like family 2
PF05593 (5/5) RHS Repeat
PF01757 (5/5) Acyltransferase family
PF01522 (5/5) Polysaccharide deacetylase
PF15657 (4/5) HNH/Endo VII superfamily nuclease toxins
precursor_groups_66296 61.81 +- 9.42 2 0 1 0 0.15 +- 0.34 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
PF13581 (1/2) Histidine kinase-like ATPase domain
PF04952 (1/2) Succinylglutamate desuccinylase / Aspartoacylase family
precursor_groups_450 31.46 +- 57.04 110 0 10 0 0.13 +- 0.13 110 5

PF04066 (110/110) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF00420 (110/110) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (110/110) Proton-conducting membrane transporter
PF13244 (109/110) Domain of unknown function (DUF4040)
PF04039 (109/110) Domain related to MnhB subunit of Na+/H+ antiporter
precursor_groups_39031 730.56 +- 559.44 2 0 1 0 0.07 +- 0.16 2 16

TIGR04458 (2/2) 4-nitrotryptophan synthase
TIGR00730 (2/2) TIGR00730 family protein
PF13649 (2/2) Methyltransferase domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF02898 (2/2) Nitric oxide synthase, oxygenase domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01745 (2/2) Isopentenyl transferase
PF01565 (2/2) FAD binding domain
PF00872 (2/2) Transposase, Mutator family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_108 105.17 +- 153.11 53 0 3 0 0.16 +- 0.21 53 19

PF00528 (44/53) Binding-protein-dependent transport system inner membrane component
PF10022 (43/53) Uncharacterized protein conserved in bacteria (DUF2264)
PF02826 (43/53) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF06628 (42/53) Catalase-related immune-responsive
PF00199 (42/53) Catalase
PF18011 (41/53) C-terminal domain found in long catalases
PF13377 (41/53) Periplasmic binding protein-like domain
PF08220 (41/53) DeoR-like helix-turn-helix domain
PF01547 (41/53) Bacterial extracellular solute-binding protein
PF06386 (40/53) Gas vesicle synthesis protein GvpL/GvpF
PF05121 (40/53) Gas vesicle protein K
PF05120 (40/53) Gas vesicle protein G
PF03364 (40/53) Polyketide cyclase / dehydrase and lipid transport
PF00741 (40/53) Gas vesicle protein
PF05800 (39/53) Gas vesicle synthesis protein GvpO
PF13649 (31/53) Methyltransferase domain
PF00106 (29/53) short chain dehydrogenase
PF16859 (27/53) Tetracyclin repressor-like, C-terminal domain
PF00440 (27/53) Bacterial regulatory proteins, tetR family
precursor_groups_2801 22.05 +- 6.49 22 0 6 0 0.19 +- 0.08 22 8

PF13377 (22/22) Periplasmic binding protein-like domain
PF12831 (22/22) FAD dependent oxidoreductase
PF07859 (22/22) alpha/beta hydrolase fold
PF06808 (22/22) Tripartite ATP-independent periplasmic transporter, DctM component
PF05378 (22/22) Hydantoinase/oxoprolinase N-terminal region
PF01968 (22/22) Hydantoinase/oxoprolinase
PF00356 (22/22) Bacterial regulatory proteins, lacI family
PF01636 (13/22) Phosphotransferase enzyme family
precursor_groups_29845 160.09 +- 88.59 2 0 0 0 0.14 +- 0.12 2 19

PF16353 (2/2) Domain of unknown function(DUF4981)
PF06182 (2/2) ABC-2 family transporter protein
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (2/2) FAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00005 (2/2) ABC transporter
PF14587 (1/2) O-Glycosyl hydrolase family 30
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF13377 (1/2) Periplasmic binding protein-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_104 181.06 +- 84.15 20 0 1 0 0.10 +- 0.16 20 3

PF13545 (12/20) Crp-like helix-turn-helix domain
PF07228 (12/20) Stage II sporulation protein E (SpoIIE)
PF00027 (12/20) Cyclic nucleotide-binding domain
precursor_groups_107 72.20 +- 43.11 5 0 1 0 0.12 +- 0.20 5 1

PF07690 (3/5) Major Facilitator Superfamily
precursor_groups_100 507.53 +- 610.86 67 0 52 67 0.06 +- 0.13 67 8

TIGR03891 (67/67) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (67/67) Lantibiotic biosynthesis dehydratase C-term
PF05147 (67/67) Lanthionine synthetase C-like protein
PF04738 (67/67) Lantibiotic dehydratase, N terminus
TIGR04364 (65/67) methyltransferase, FxLD system
PF01135 (65/67) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
TIGR04363 (64/67) FxLD family lantipeptide
PF00005 (42/67) ABC transporter
precursor_groups_27234 37.34 +- 3.28 4 0 0 0 0.11 +- 0.13 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02781 (4/4) Glucose-6-phosphate dehydrogenase, C-terminal domain
PF00106 (4/4) short chain dehydrogenase
precursor_groups_35539 35.94 +- 24.36 3 0 0 0 0.14 +- 0.08 3 5

PF12833 (3/3) Helix-turn-helix domain
PF12697 (3/3) Alpha/beta hydrolase family
PF05141 (3/3) Pyoverdine/dityrosine biosynthesis protein
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00067 (3/3) Cytochrome P450
precursor_groups_17039 361.14 +- 262.86 2 0 0 0 0.03 +- 0.02 2 4

PF13546 (2/2) DDE superfamily endonuclease
PF07702 (2/2) UTRA domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_298 168.84 +- 175.08 16 0 0 0 0.09 +- 0.20 16 7

PF07690 (15/16) Major Facilitator Superfamily
PF07228 (15/16) Stage II sporulation protein E (SpoIIE)
PF01551 (13/16) Peptidase family M23
PF00291 (12/16) Pyridoxal-phosphate dependent enzyme
PF07739 (11/16) TipAS antibiotic-recognition domain
PF13411 (10/16) MerR HTH family regulatory protein
PF00248 (8/16) Aldo/keto reductase family
precursor_groups_294 295.08 +- 364.67 6 0 1 0 0.07 +- 0.13 6 1

PF00106 (3/6) short chain dehydrogenase
precursor_groups_4561 120.34 +- 103.15 3 0 0 0 0.07 +- 0.21 3 7

TIGR00498 (3/3) repressor LexA
PF11799 (3/3) impB/mucB/samB family C-terminal domain
PF01726 (3/3) LexA DNA binding domain
PF00717 (3/3) Peptidase S24-like
PF17657 (2/3) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/3) Helix-hairpin-helix motif
PF07733 (2/3) Bacterial DNA polymerase III alpha NTPase domain
precursor_groups_296 2734.16 +- 2725.84 2 0 1 1 0.07 +- 0.22 2 14

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00020 (1/2) peptide chain release factor 2
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/2) Helix-turn-helix domain
PF04464 (1/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF04149 (1/2) Domain of unknown function (DUF397)
PF03462 (1/2) PCRF domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/2) Nitroreductase family
PF00535 (1/2) Glycosyl transferase family 2
PF00472 (1/2) RF-1 domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_38817 65.11 +- 20.89 2 0 2 0 0.13 +- 0.24 2 9

PF18029 (2/2) Glyoxalase-like domain
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05401 (2/2) Nodulation protein S (NodS)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00107 (2/2) Zinc-binding dehydrogenase
PF01276 (1/2) Orn/Lys/Arg decarboxylase, major domain
precursor_groups_12981 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
precursor_groups_15908 171.39 +- 0.64 2 0 2 0 0.09 +- 0.25 2 21

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF08659 (2/2) KR domain
PF05199 (2/2) GMC oxidoreductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00732 (2/2) GMC oxidoreductase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_5466 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_60984 72.50 +- 12.83 2 0 0 0 0.17 +- 0.30 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00630 (2/2) excinuclease ABC subunit A
PF17760 (2/2) UvrA interaction domain
PF17755 (2/2) UvrA DNA-binding domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13280 (2/2) WYL domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF00140 (2/2) Sigma-70 factor, region 1.2
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_groups_60988 260.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_71417 291.65 +- 224.35 2 0 0 0 0.03 +- 0.06 2 4

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_71412 50.30 +- 3.87 2 0 2 2 0.08 +- 0.05 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_856 222.38 +- 224.29 58 0 9 0 0.07 +- 0.07 58 13

TIGR01850 (57/58) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (57/58) alpha-L-glutamate ligase, RimK family
PF08443 (57/58) RimK-like ATP-grasp domain
PF02812 (57/58) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (57/58) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (57/58) Amino acid kinase family
PF00682 (57/58) HMGL-like
PF00501 (57/58) AMP-binding enzyme
PF00208 (57/58) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00117 (57/58) Glutamine amidotransferase class-I
PF13193 (56/58) AMP-binding enzyme C-terminal domain
PF00155 (50/58) Aminotransferase class I and II
PF02774 (37/58) Semialdehyde dehydrogenase, dimerisation domain
precursor_groups_38786 678.69 +- 611.31 2 0 0 0 0.08 +- 0.25 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00480 (2/2) ROK family
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
precursor_groups_30795 106.42 +- 47.85 4 0 0 0 0.02 +- 0.01 4 2

TIGR03930 (4/4) WXG100 family type VII secretion target
PF06013 (4/4) Proteins of 100 residues with WXG
precursor_groups_65596 175.06 +- 37.41 2 0 0 0 0.03 +- 0.04 2 9

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_39494 203.96 +- 84.80 3 0 0 0 0.07 +- 0.09 3 9

TIGR01972 (3/3) proton-translocating NADH-quinone oxidoreductase, chain M
PF07732 (3/3) Multicopper oxidase
PF07731 (3/3) Multicopper oxidase
PF00507 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00394 (3/3) Multicopper oxidase
PF00361 (3/3) Proton-conducting membrane transporter
PF00146 (3/3) NADH dehydrogenase
precursor_groups_39496 67.92 +- 14.39 2 0 0 0 0.18 +- 0.35 2 9

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03815 (2/2) helicase/secretion neighborhood CpaE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03816 (1/2) helicase/secretion neighborhood TadE-like protein
PF07811 (1/2) TadE-like protein
precursor_groups_39365 2433.09 +- 685.07 3 0 3 3 0.01 +- 0.01 3 14

TIGR01733 (3/3) amino acid adenylation domain
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF18130 (3/3) ATP-grasp N-terminal domain
PF13537 (3/3) Glutamine amidotransferase domain
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03547 (3/3) Membrane transport protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01063 (3/3) Amino-transferase class IV
PF00733 (3/3) Asparagine synthase
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00144 (3/3) Beta-lactamase
precursor_groups_72197 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_11767 65.63 +- 87.48 6 0 6 0 0.17 +- 0.36 6 6

PF11236 (6/6) Protein of unknown function (DUF3037)
PF00067 (6/6) Cytochrome P450
TIGR01751 (5/6) crotonyl-CoA carboxylase/reductase
PF08240 (5/6) Alcohol dehydrogenase GroES-like domain
PF05721 (5/6) Phytanoyl-CoA dioxygenase (PhyH)
PF00107 (5/6) Zinc-binding dehydrogenase
precursor_groups_67533 223.36 +- 10.64 2 0 0 0 0.04 +- 0.04 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF08532 (1/2) Beta-galactosidase trimerisation domain
PF02449 (1/2) Beta-galactosidase
precursor_groups_5660 79.61 +- 20.42 12 0 0 0 0.17 +- 0.06 12 16

TIGR03356 (12/12) beta-galactosidase
TIGR01727 (12/12) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13377 (12/12) Periplasmic binding protein-like domain
PF12911 (12/12) N-terminal TM domain of oligopeptide transport permease C
PF08352 (12/12) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (12/12) Binding-protein-dependent transport system inner membrane component
PF00496 (12/12) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (12/12) Bacterial regulatory proteins, lacI family
PF00232 (12/12) Glycosyl hydrolase family 1
PF00005 (12/12) ABC transporter
PF03425 (10/12) Carbohydrate binding domain (family 11)
PF03160 (10/12) Calx-beta domain
PF01915 (10/12) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (10/12) Glycosyl hydrolase family 3 N terminal domain
PF00754 (9/12) F5/8 type C domain
PF00722 (9/12) Glycosyl hydrolases family 16
precursor_groups_10425 38.24 +- 1.45 2 0 1 0 0.15 +- 0.12 2 10

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF12138 (2/2) Spherulation-specific family 4
PF11997 (2/2) Domain of unknown function (DUF3492)
PF03537 (2/2) Glycoside-hydrolase family GH114
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00534 (2/2) Glycosyl transferases group 1
PF00483 (2/2) Nucleotidyl transferase
PF07690 (1/2) Major Facilitator Superfamily
PF01494 (1/2) FAD binding domain
PF00383 (1/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_31021 39.79 +- 9.21 3 0 3 0 0.13 +- 0.20 3 11

PF13478 (3/3) XdhC Rossmann domain
PF07728 (3/3) AAA domain (dynein-related subfamily)
PF06240 (3/3) Carbon monoxide dehydrogenase subunit G (CoxG)
PF05762 (3/3) VWA domain containing CoxE-like protein
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_28215 32.67 +- 14.24 2 0 0 0 0.11 +- 0.19 2 10

PF07690 (2/2) Major Facilitator Superfamily
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00108 (2/2) Thiolase, N-terminal domain
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF07591 (1/2) Pretoxin HINT domain
precursor_groups_47110 26.57 +- 7.84 2 0 0 0 0.12 +- 0.08 2 6

PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13411 (2/2) MerR HTH family regulatory protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_43300 64.76 +- 3.28 2 0 1 0 0.23 +- 0.22 2 18

TIGR00839 (2/2) aspartate ammonia-lyase
PF10415 (2/2) Fumarase C C-terminus
PF07729 (2/2) FCD domain
PF06089 (2/2) L-asparaginase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF00206 (2/2) Lyase
PF18631 (1/2) Cucumopine synthase C-terminal helical bundle domain
PF17203 (1/2) Single cache domain 3
PF14689 (1/2) Sensor_kinase_SpoOB-type, alpha-helical domain
PF09339 (1/2) IclR helix-turn-helix domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01266 (1/2) FAD dependent oxidoreductase
PF00989 (1/2) PAS fold
PF00501 (1/2) AMP-binding enzyme
PF00171 (1/2) Aldehyde dehydrogenase family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_49943 347.93 +- 153.74 2 0 2 2 0.05 +- 0.08 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_926 667.99 +- 630.34 2 0 1 2 0.03 +- 0.03 2 13

PF01348 (2/2) Type II intron maturase
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04149 (1/2) Domain of unknown function (DUF397)
PF04055 (1/2) Radical SAM superfamily
PF01610 (1/2) Transposase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_12109 150.50 +- 136.83 4 0 0 0 0.03 +- 0.02 4 3

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)
precursor_groups_17468 329.78 +- 46.39 6 0 6 0 0.02 +- 0.02 6 12

TIGR01458 (6/6) HAD hydrolase, TIGR01458 family
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF13535 (6/6) ATP-grasp domain
PF13344 (6/6) Haloacid dehalogenase-like hydrolase
PF13242 (6/6) HAD-hyrolase-like
PF07690 (6/6) Major Facilitator Superfamily
PF03364 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF01663 (6/6) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01326 (6/6) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00391 (6/6) PEP-utilising enzyme, mobile domain
PF00149 (6/6) Calcineurin-like phosphoesterase
precursor_groups_72635 104.00 +- 0.00 2 0 0 0 0.04 +- 0.02 2 3

PF08445 (2/2) FR47-like protein
PF04326 (2/2) Putative DNA-binding domain
PF03235 (2/2) Protein of unknown function DUF262
precursor_groups_33975 38.21 +- 6.71 3 0 3 0 0.05 +- 0.05 3 3

TIGR02353 (3/3) non-ribosomal peptide synthetase terminal domain of unknown function
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
precursor_groups_83943 389.00 +- 131.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF08031 (2/2) Berberine and berberine like
PF07366 (2/2) SnoaL-like polyketide cyclase
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01565 (2/2) FAD binding domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_61909 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_83945 216.00 +- 44.00 2 0 2 0 0.01 +- 0.00 2 5

TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_42835 21.72 +- 3.21 3 0 0 0 0.14 +- 0.06 3 6

PF13183 (3/3) 4Fe-4S dicluster domain
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF01565 (3/3) FAD binding domain
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_53704 511.20 +- 498.94 2 0 1 0 0.06 +- 0.18 2 30

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
TIGR01733 (1/2) amino acid adenylation domain
TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (1/2) aminodeoxychorismate synthase, component I
PF16363 (1/2) GDP-mannose 4,6 dehydratase
PF13579 (1/2) Glycosyl transferase 4-like domain
PF13489 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12848 (1/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF05014 (1/2) Nucleoside 2-deoxyribosyltransferase
PF04978 (1/2) Protein of unknown function (DUF664)
PF04715 (1/2) Anthranilate synthase component I, N terminal region
PF03559 (1/2) NDP-hexose 2,3-dehydratase
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01063 (1/2) Amino-transferase class IV
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00550 (1/2) Phosphopantetheine attachment site
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00483 (1/2) Nucleotidyl transferase
PF00464 (1/2) Serine hydroxymethyltransferase
PF00425 (1/2) chorismate binding enzyme
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter
precursor_groups_42549 506.10 +- 273.90 2 0 0 0 0.01 +- 0.00 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
PF12146 (1/2) Serine aminopeptidase, S33
PF00561 (1/2) alpha/beta hydrolase fold
precursor_groups_1411 14.95 +- 2.90 9 0 0 0 0.19 +- 0.16 9 6

PF13378 (9/9) Enolase C-terminal domain-like
PF02746 (9/9) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00294 (9/9) pfkB family carbohydrate kinase
TIGR02605 (7/9) putative regulatory protein, FmdB family
PF14325 (7/9) Domain of unknown function (DUF4383)
PF09723 (7/9) Zinc ribbon domain
precursor_groups_35315 582.00 +- 192.00 2 0 0 0 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_groups_42093 279.92 +- 107.08 2 0 2 0 0.05 +- 0.04 2 10

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_80550 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region
precursor_groups_42544 166.12 +- 93.88 2 0 0 0 0.02 +- 0.02 2 4

TIGR03666 (2/2) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07335 (2/2) Fungal chitosanase of glycosyl hydrolase group 75
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00144 (2/2) Beta-lactamase
precursor_groups_2069 130.81 +- 128.20 23 0 23 0 0.10 +- 0.20 23 4

PF07690 (23/23) Major Facilitator Superfamily
PF03756 (23/23) A-factor biosynthesis hotdog domain
PF00484 (23/23) Carbonic anhydrase
PF00916 (21/23) Sulfate permease family
precursor_groups_31150 80.99 +- 11.14 2 0 2 0 0.11 +- 0.28 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_84407 129.59 +- 16.48 2 0 0 0 0.17 +- 0.16 2 8

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_84405 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_16122 67.88 +- 54.90 4 0 0 0 0.10 +- 0.10 4 8

PF12697 (4/4) Alpha/beta hydrolase family
PF07045 (4/4) Domain of unknown function (DUF1330)
PF02036 (4/4) SCP-2 sterol transfer family
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (4/4) short chain dehydrogenase
PF00037 (4/4) 4Fe-4S binding domain
PF00970 (2/4) Oxidoreductase FAD-binding domain
precursor_groups_82830 1354.09 +- 64.09 2 0 0 0 0.01 +- 0.00 2 10

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF14832 (2/2) Putative oxalocrotonate tautomerase enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF00892 (2/2) EamA-like transporter family
PF00857 (2/2) Isochorismatase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_67985 83.01 +- 1.06 2 0 0 0 0.14 +- 0.07 2 14

TIGR03356 (2/2) beta-galactosidase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00005 (2/2) ABC transporter
precursor_groups_23939 3050.28 +- 2074.67 4 0 4 4 0.01 +- 0.00 4 10

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00005 (4/4) ABC transporter
PF12679 (2/4) ABC-2 family transporter protein
precursor_groups_19252 171.74 +- 86.26 2 0 0 0 0.06 +- 0.06 2 14

PF13564 (2/2) DoxX-like family
TIGR01494 (1/2) HAD ATPase, P-type, family IC
TIGR01217 (1/2) acetoacetate-CoA ligase
PF16177 (1/2) Acetyl-coenzyme A synthetase N-terminus
PF13246 (1/2) Cation transport ATPase (P-type)
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00690 (1/2) Cation transporter/ATPase, N-terminus
PF00689 (1/2) Cation transporting ATPase, C-terminus
PF00501 (1/2) AMP-binding enzyme
PF00122 (1/2) E1-E2 ATPase
precursor_groups_5985 1449.80 +- 996.72 5 0 1 0 0.02 +- 0.03 5 4

PF07811 (4/5) TadE-like protein
PF00482 (4/5) Type II secretion system (T2SS), protein F
PF00437 (4/5) Type II/IV secretion system protein
PF08666 (3/5) SAF domain
precursor_groups_23936 1163.00 +- 222.30 4 0 1 0 0.01 +- 0.00 4 5

PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF07690 (4/4) Major Facilitator Superfamily
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00535 (3/4) Glycosyl transferase family 2
precursor_groups_34573 13.49 +- 3.93 3 0 0 0 0.16 +- 0.09 3 2

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF04616 (3/3) Glycosyl hydrolases family 43
precursor_groups_85282 144.57 +- 0.26 2 0 2 0 0.13 +- 0.25 2 21

PF13602 (2/2) Zinc-binding dehydrogenase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF13358 (1/2) DDE superfamily endonuclease
PF05977 (1/2) Transmembrane secretion effector
PF01039 (1/2) Carboxyl transferase domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_52076 139.98 +- 39.33 2 0 0 0 0.04 +- 0.04 2 6

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_41867 259.33 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
precursor_groups_66878 39.62 +- 13.44 2 0 0 0 0.19 +- 0.30 2 7

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_33495 239.74 +- 139.79 3 0 3 3 0.05 +- 0.04 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_30959 461.13 +- 364.31 4 0 0 0 0.08 +- 0.19 4 18

TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01428 (4/4) haloacid dehalogenase, type II
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (4/4) FCD domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00005 (4/4) ABC transporter
TIGR01297 (3/4) cation diffusion facilitator family transporter
PF16916 (3/4) Dimerisation domain of Zinc Transporter
PF01545 (3/4) Cation efflux family
PF00171 (3/4) Aldehyde dehydrogenase family
PF17189 (2/4) Glycosyl hydrolase family 30 beta sandwich domain
PF12840 (2/4) Helix-turn-helix domain
PF07690 (2/4) Major Facilitator Superfamily
PF00581 (2/4) Rhodanese-like domain
precursor_groups_18784 98.56 +- 110.67 4 0 0 0 0.14 +- 0.30 4 8

PF13183 (4/4) 4Fe-4S dicluster domain
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01565 (4/4) FAD binding domain
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
precursor_groups_78567 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_groups_36866 332.14 +- 118.84 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family
precursor_groups_65576 692.30 +- 210.70 2 0 0 0 0.01 +- 0.00 2 10

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (2/2) Methyltransferase domain
PF13570 (2/2) PQQ-like domain
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
precursor_groups_85041 203.61 +- 44.72 2 0 0 0 0.06 +- 0.01 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_groups_17518 47.44 +- 14.97 6 0 0 6 0.08 +- 0.10 6 6

TIGR01536 (6/6) asparagine synthase (glutamine-hydrolyzing)
PF13622 (6/6) Thioesterase-like superfamily
PF13537 (6/6) Glutamine amidotransferase domain
PF07690 (6/6) Major Facilitator Superfamily
PF01425 (6/6) Amidase
PF00733 (6/6) Asparagine synthase
precursor_groups_12742 191.19 +- 28.66 7 0 7 0 0.02 +- 0.01 7 6

PF13378 (7/7) Enolase C-terminal domain-like
PF05336 (7/7) L-rhamnose mutarotase
PF04909 (7/7) Amidohydrolase
PF02746 (7/7) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (7/7) Bacterial extracellular solute-binding protein
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
precursor_groups_76435 2103.65 +- 1040.54 2 0 0 2 0.02 +- 0.05 2 23

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (2/2) Asparagine synthase
PF00550 (2/2) Phosphopantetheine attachment site
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00293 (2/2) NUDIX domain
PF00155 (2/2) Aminotransferase class I and II
PF13527 (1/2) Acetyltransferase (GNAT) domain
PF07690 (1/2) Major Facilitator Superfamily
PF04828 (1/2) Glutathione-dependent formaldehyde-activating enzyme
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_12745 41.87 +- 25.41 4 0 0 0 0.07 +- 0.03 4 2

PF06751 (4/4) Ethanolamine ammonia lyase large subunit (EutB)
PF05985 (4/4) Ethanolamine ammonia-lyase light chain (EutC)
precursor_groups_22358 19.85 +- 5.46 5 0 0 0 0.11 +- 0.11 5 2

PF11203 (5/5) Putative type VII ESX secretion system translocon, EccE
PF00877 (5/5) NlpC/P60 family
precursor_groups_3199 1927.84 +- 1009.74 6 0 6 6 0.03 +- 0.14 6 5

PF05147 (6/6) Lanthionine synthetase C-like protein
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
PF02441 (5/6) Flavoprotein
PF00069 (5/6) Protein kinase domain
precursor_groups_40544 28.81 +- 8.01 2 0 0 0 0.15 +- 0.26 2 6

PF09981 (2/2) Uncharacterized protein conserved in bacteria (DUF2218)
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_groups_16390 129.00 +- 0.00 6 0 6 0 0.02 +- 0.00 6 2

PF03972 (6/6) MmgE/PrpD family
PF00781 (6/6) Diacylglycerol kinase catalytic domain
precursor_groups_6960 113.62 +- 60.94 3 0 0 0 0.04 +- 0.02 3 4

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF01613 (3/3) Flavin reductase like domain
PF00501 (3/3) AMP-binding enzyme
precursor_groups_76322 740.63 +- 220.63 2 0 0 0 0.02 +- 0.03 2 14

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07859 (2/2) alpha/beta hydrolase fold
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
TIGR00229 (1/2) PAS domain S-box protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF08448 (1/2) PAS fold
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04213 (1/2) Htaa
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
precursor_groups_6962 62.17 +- 24.07 4 0 0 0 0.17 +- 0.15 4 19

TIGR01374 (4/4) sarcosine oxidase, delta subunit family
TIGR01373 (4/4) sarcosine oxidase, beta subunit family
PF16350 (4/4) FAD dependent oxidoreductase central domain
PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (4/4) Glycine cleavage T-protein C-terminal barrel domain
PF04267 (4/4) Sarcosine oxidase, delta subunit family
PF04069 (4/4) Substrate binding domain of ABC-type glycine betaine transport system
PF02882 (4/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (4/4) Aminomethyltransferase folate-binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00763 (4/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
TIGR01186 (3/4) glycine betaine/L-proline transport ATP binding subunit
PF17806 (3/4) Sarcosine oxidase A3 domain
PF07992 (3/4) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (3/4) Sarcosine oxidase, gamma subunit family
PF00171 (3/4) Aldehyde dehydrogenase family
PF00005 (3/4) ABC transporter
TIGR01372 (2/4) sarcosine oxidase, alpha subunit family
precursor_groups_74613 35.29 +- 4.71 2 0 0 0 0.06 +- 0.02 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07859 (2/2) alpha/beta hydrolase fold
precursor_groups_41968 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_6967 13.82 +- 0.84 2 0 2 0 0.22 +- 0.12 2 6

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF05853 (2/2) beta-keto acid cleavage enzyme
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_81571 58.29 +- 19.11 2 0 0 2 0.17 +- 0.25 2 5

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01425 (2/2) Amidase
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_6965 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_3196 68.60 +- 35.38 5 0 0 0 0.17 +- 0.26 5 5

PF02983 (5/5) Alpha-lytic protease prodomain
PF00089 (5/5) Trypsin
PF13454 (3/5) FAD-NAD(P)-binding
PF07920 (3/5) Protein of unknown function (DUF1684)
PF00296 (3/5) Luciferase-like monooxygenase
precursor_groups_6108 254.17 +- 186.48 12 0 12 12 0.06 +- 0.15 12 12

PF05147 (12/12) Lanthionine synthetase C-like protein
TIGR03891 (11/12) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/12) Lantibiotic biosynthesis dehydratase C-term
PF04738 (11/12) Lantibiotic dehydratase, N terminus
PF00296 (11/12) Luciferase-like monooxygenase
PF00196 (11/12) Bacterial regulatory proteins, luxR family
PF00072 (11/12) Response regulator receiver domain
PF00005 (11/12) ABC transporter
PF13649 (9/12) Methyltransferase domain
PF01292 (6/12) Prokaryotic cytochrome b561
PF00188 (6/12) Cysteine-rich secretory protein family
PF00174 (6/12) Oxidoreductase molybdopterin binding domain
precursor_groups_49090 258.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 3

PF13649 (2/2) Methyltransferase domain
PF13460 (2/2) NAD(P)H-binding
PF01494 (2/2) FAD binding domain
precursor_groups_55398 103.66 +- 11.52 2 0 0 0 0.04 +- 0.07 2 10

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF01614 (2/2) Bacterial transcriptional regulator
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00501 (1/2) AMP-binding enzyme
PF00175 (1/2) Oxidoreductase NAD-binding domain
precursor_groups_72735 51.86 +- 4.58 2 0 2 0 0.08 +- 0.10 2 8

TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01794 (2/2) Ferric reductase like transmembrane component
PF01590 (2/2) GAF domain
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF00494 (2/2) Squalene/phytoene synthase
PF00005 (2/2) ABC transporter
precursor_groups_55397 174.11 +- 32.29 2 0 0 2 0.02 +- 0.03 2 6

PF13023 (2/2) HD domain
PF12671 (2/2) Putative amidase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF01634 (2/2) ATP phosphoribosyltransferase
precursor_groups_72732 461.05 +- 11.67 2 0 0 0 0.04 +- 0.01 2 17

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
precursor_groups_29094 798.47 +- 421.16 3 0 3 0 0.03 +- 0.02 3 24

TIGR01733 (3/3) amino acid adenylation domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14518 (3/3) Iron-containing redox enzyme
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09334 (3/3) tRNA synthetases class I (M)
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (3/3) Saccharopine dehydrogenase NADP binding domain
PF03417 (3/3) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_77816 2340.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 11

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_71347 1013.89 +- 362.11 2 0 0 0 0.01 +- 0.01 2 9

PF13483 (2/2) Beta-lactamase superfamily domain
PF09084 (2/2) NMT1/THI5 like
PF03972 (2/2) MmgE/PrpD family
PF03466 (2/2) LysR substrate binding domain
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF01361 (2/2) Tautomerase enzyme
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (2/2) ABC transporter
precursor_groups_43124 48.09 +- 17.09 3 0 0 0 0.20 +- 0.30 3 4

PF05336 (2/3) L-rhamnose mutarotase
PF02983 (2/3) Alpha-lytic protease prodomain
PF00754 (2/3) F5/8 type C domain
PF00722 (2/3) Glycosyl hydrolases family 16
precursor_groups_26057 662.17 +- 72.93 4 0 4 0 0.01 +- 0.00 4 17

TIGR01679 (4/4) FAD-linked oxidoreductase
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01122 (4/4) branched-chain amino acid aminotransferase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08666 (4/4) SAF domain
PF04321 (4/4) RmlD substrate binding domain
PF04030 (4/4) D-arabinono-1,4-lactone oxidase
PF03737 (4/4) Aldolase/RraA
PF03102 (4/4) NeuB family
PF02780 (4/4) Transketolase, C-terminal domain
PF02779 (4/4) Transketolase, pyrimidine binding domain
PF01565 (4/4) FAD binding domain
PF01063 (4/4) Amino-transferase class IV
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
TIGR00473 (3/4) CDP-diacylglycerol-serine O-phosphatidyltransferase
PF01066 (3/4) CDP-alcohol phosphatidyltransferase
precursor_groups_85313 173.33 +- 86.67 2 0 0 0 0.02 +- 0.01 2 2

PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_groups_14960 26.42 +- 6.37 2 0 2 0 0.20 +- 0.11 2 11

TIGR04316 (2/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
TIGR02275 (2/2) (2,3-dihydroxybenzoyl)adenylate synthase
TIGR00543 (2/2) isochorismate synthase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07497 (2/2) Rho termination factor, RNA-binding domain
PF00857 (2/2) Isochorismatase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00006 (2/2) ATP synthase alpha/beta family, nucleotide-binding domain
precursor_groups_22535 37.81 +- 13.01 4 0 0 0 0.06 +- 0.02 4 2

PF03780 (4/4) Asp23 family, cell envelope-related function
PF00795 (4/4) Carbon-nitrogen hydrolase
precursor_groups_16339 52.54 +- 1.04 3 0 0 0 0.19 +- 0.29 3 8

TIGR03814 (3/3) glutaminase A
TIGR00494 (3/3) protein CrcB
PF12840 (3/3) Helix-turn-helix domain
PF09594 (3/3) Glycosyltransferase family 87
PF07745 (3/3) Glycosyl hydrolase family 53
PF04960 (3/3) Glutaminase
PF03088 (3/3) Strictosidine synthase
PF02537 (3/3) CrcB-like protein, Camphor Resistance (CrcB)
precursor_groups_19328 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_groups_36096 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_groups_44302 232.51 +- 39.34 3 0 0 0 0.05 +- 0.09 3 11

TIGR00326 (3/3) riboflavin biosynthesis protein RibD
PF12894 (3/3) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (3/3) Major Facilitator Superfamily
PF07676 (3/3) WD40-like Beta Propeller Repeat
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (3/3) RibD C-terminal domain
PF00925 (3/3) GTP cyclohydrolase II
PF00400 (3/3) WD domain, G-beta repeat
PF00383 (3/3) Cytidine and deoxycytidylate deaminase zinc-binding region
TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13641 (2/3) Glycosyltransferase like family 2
precursor_groups_73733 65.89 +- 10.21 2 0 0 0 0.19 +- 0.28 2 13

PF13378 (2/2) Enolase C-terminal domain-like
PF13229 (2/2) Right handed beta helix region
PF13183 (2/2) 4Fe-4S dicluster domain
PF11870 (2/2) Domain of unknown function (DUF3390)
PF07859 (2/2) alpha/beta hydrolase fold
PF07729 (2/2) FCD domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02589 (2/2) LUD domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_76283 316.67 +- 30.00 2 0 2 2 0.01 +- 0.01 2 6

TIGR04451 (2/2) lantipeptide, SCO0268 family
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00144 (2/2) Beta-lactamase
precursor_groups_6581 95.83 +- 26.45 5 0 0 0 0.02 +- 0.02 5 5

PF13649 (5/5) Methyltransferase domain
PF07504 (5/5) Fungalysin/Thermolysin Propeptide Motif
PF02868 (5/5) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (5/5) Proprotein convertase P-domain
PF01447 (5/5) Thermolysin metallopeptidase, catalytic domain
precursor_groups_60420 78.41 +- 20.21 2 0 0 0 0.14 +- 0.20 2 11

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04978 (2/2) Protein of unknown function (DUF664)
PF01590 (2/2) GAF domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF18029 (1/2) Glyoxalase-like domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00872 (1/2) Transposase, Mutator family
precursor_groups_48159 812.16 +- 80.91 2 0 2 0 0.02 +- 0.04 2 10

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03412 (2/2) Peptidase C39 family
PF01636 (2/2) Phosphotransferase enzyme family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_61117 328.50 +- 58.50 2 0 0 0 0.01 +- 0.00 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
precursor_groups_547 29.11 +- 7.58 3 0 0 0 0.15 +- 0.22 3 1

PF00132 (2/3) Bacterial transferase hexapeptide (six repeats)
precursor_groups_3223 1072.06 +- 648.71 24 0 2 0 0.02 +- 0.01 24 6

PF07811 (24/24) TadE-like protein
PF01476 (24/24) LysM domain
PF00482 (24/24) Type II secretion system (T2SS), protein F
PF00437 (24/24) Type II/IV secretion system protein
PF08666 (22/24) SAF domain
PF13400 (21/24) Putative Flp pilus-assembly TadE/G-like
precursor_groups_68668 38.91 +- 7.53 2 0 0 0 0.08 +- 0.05 2 4

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_groups_3999 13.82 +- 3.33 12 0 1 0 0.16 +- 0.12 12 5

PF05331 (12/12) Protein of unknown function (DUF742)
PF03259 (12/12) Roadblock/LC7 domain
PF03029 (12/12) Conserved hypothetical ATP binding protein
PF00672 (12/12) HAMP domain
PF02518 (11/12) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_7741 324.88 +- 45.69 11 0 2 0 0.09 +- 0.23 11 19

PF07690 (11/11) Major Facilitator Superfamily
TIGR01902 (10/11) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (10/11) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (10/11) alpha-L-glutamate ligase, RimK family
PF18603 (10/11) L-amino acid ligase C-terminal domain 2
PF18130 (10/11) ATP-grasp N-terminal domain
PF13535 (10/11) ATP-grasp domain
PF08443 (10/11) RimK-like ATP-grasp domain
PF02779 (10/11) Transketolase, pyrimidine binding domain
PF01546 (10/11) Peptidase family M20/M25/M40
PF01118 (10/11) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (10/11) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (10/11) Amino acid kinase family
PF00456 (10/11) Transketolase, thiamine diphosphate binding domain
PF00664 (9/11) ABC transporter transmembrane region
PF00005 (9/11) ABC transporter
PF13560 (8/11) Helix-turn-helix domain
PF10901 (8/11) Protein of unknown function (DUF2690)
PF01471 (8/11) Putative peptidoglycan binding domain
precursor_groups_23240 65.45 +- 73.71 5 0 5 0 0.11 +- 0.20 5 6

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00501 (5/5) AMP-binding enzyme
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF00171 (5/5) Aldehyde dehydrogenase family
precursor_groups_7743 488.44 +- 38.97 3 0 3 3 0.01 +- 0.00 3 7

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (3/3) luciferase family oxidoreductase, group 1
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
precursor_groups_7362 65.11 +- 20.89 2 0 2 0 0.13 +- 0.24 2 9

PF18029 (2/2) Glyoxalase-like domain
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05401 (2/2) Nodulation protein S (NodS)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00107 (2/2) Zinc-binding dehydrogenase
PF01276 (1/2) Orn/Lys/Arg decarboxylase, major domain
precursor_groups_68448 130.62 +- 30.62 2 0 0 2 0.04 +- 0.07 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF12840 (1/2) Helix-turn-helix domain
precursor_groups_62305 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_29899 776.00 +- 2.83 3 0 0 0 0.01 +- 0.00 3 5

TIGR01473 (3/3) protoheme IX farnesyltransferase
PF04261 (3/3) Dyp-type peroxidase family
PF01040 (3/3) UbiA prenyltransferase family
TIGR01413 (2/3) Dyp-type peroxidase family
PF07690 (2/3) Major Facilitator Superfamily
precursor_groups_86061 645.00 +- 129.00 2 0 2 0 0.01 +- 0.01 2 12

PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00866 (2/2) Ring hydroxylating beta subunit
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_69669 1340.26 +- 160.83 2 0 0 0 0.01 +- 0.01 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_69915 72.38 +- 43.72 2 0 2 1 0.18 +- 0.18 2 21

TIGR02050 (2/2) carboxylate-amine ligase, YbdK family
TIGR01382 (2/2) intracellular protease, PfpI family
PF17196 (2/2) Protein of unknown function (DUF5133)
PF13828 (2/2) Domain of unknown function (DUF4190)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF08768 (2/2) Domain of unknown function (DUF1794)
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04954 (2/2) Siderophore-interacting protein
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF03621 (2/2) MbtH-like protein
PF01965 (2/2) DJ-1/PfpI family
PF01594 (2/2) AI-2E family transporter
PF00037 (2/2) 4Fe-4S binding domain
TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF13360 (1/2) PQQ-like domain
PF05406 (1/2) WGR domain
PF03707 (1/2) Bacterial signalling protein N terminal repeat
PF01341 (1/2) Glycosyl hydrolases family 6
PF00942 (1/2) Cellulose binding domain
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_7368 53.59 +- 27.70 9 0 2 0 0.15 +- 0.25 9 15

PF02894 (8/9) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/9) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (8/9) Xylose isomerase-like TIM barrel
TIGR04382 (7/9) 5-dehydro-2-deoxygluconokinase
TIGR04377 (7/9) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
PF02776 (7/9) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/9) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00294 (7/9) pfkB family carbohydrate kinase
PF00205 (7/9) Thiamine pyrophosphate enzyme, central domain
TIGR04378 (6/9) 5-deoxy-glucuronate isomerase
TIGR01722 (6/9) methylmalonate-semialdehyde dehydrogenase (acylating)
PF04962 (6/9) KduI/IolB family
PF00171 (6/9) Aldehyde dehydrogenase family
TIGR00879 (5/9) MFS transporter, sugar porter (SP) family
PF00083 (5/9) Sugar (and other) transporter
precursor_groups_81281 1672.51 +- 687.25 2 0 0 0 0.01 +- 0.01 2 13

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF14239 (1/2) RRXRR protein
PF13814 (1/2) Replication-relaxation
PF12846 (1/2) AAA-like domain
PF12642 (1/2) Conjugative transposon protein TcpC
PF01844 (1/2) HNH endonuclease
PF00877 (1/2) NlpC/P60 family
PF00691 (1/2) OmpA family
precursor_groups_12258 64.85 +- 0.11 3 0 0 0 0.25 +- 0.30 3 12

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF18029 (3/3) Glyoxalase-like domain
PF12704 (3/3) MacB-like periplasmic core domain
PF12697 (3/3) Alpha/beta hydrolase family
PF08281 (3/3) Sigma-70, region 4
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07730 (3/3) Histidine kinase
PF04542 (3/3) Sigma-70 region 2
PF02687 (3/3) FtsX-like permease family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_groups_11216 222.99 +- 150.96 4 0 0 0 0.06 +- 0.11 4 4

TIGR01382 (4/4) intracellular protease, PfpI family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF01965 (4/4) DJ-1/PfpI family
PF03928 (3/4) Haem-degrading
precursor_groups_18125 242.84 +- 37.96 2 0 1 0 0.04 +- 0.02 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF07532 (1/2) Bacterial Ig-like domain (group 4)
PF00754 (1/2) F5/8 type C domain
precursor_groups_80972 2399.40 +- 696.60 2 0 0 0 0.01 +- 0.00 2 12

PF17914 (2/2) HopA1 effector protein family
PF09335 (2/2) SNARE associated Golgi protein
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00891 (2/2) O-methyltransferase domain
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_5132 60.23 +- 18.22 4 0 0 0 0.04 +- 0.02 4 3

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (4/4) MDMPI C-terminal domain
precursor_groups_64989 183.91 +- 13.29 2 0 0 0 0.08 +- 0.06 2 18

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_groups_8637 137.58 +- 46.53 6 0 3 0 0.09 +- 0.21 6 19

PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF00561 (6/6) alpha/beta hydrolase fold
PF00202 (6/6) Aminotransferase class-III
PF00171 (6/6) Aldehyde dehydrogenase family
PF00107 (6/6) Zinc-binding dehydrogenase
PF13581 (5/6) Histidine kinase-like ATPase domain
PF13561 (5/6) Enoyl-(Acyl carrier protein) reductase
PF13450 (5/6) NAD(P)-binding Rossmann-like domain
PF13193 (5/6) AMP-binding enzyme C-terminal domain
PF07228 (5/6) Stage II sporulation protein E (SpoIIE)
PF05721 (5/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain
PF01636 (5/6) Phosphotransferase enzyme family
PF00501 (5/6) AMP-binding enzyme
PF00474 (5/6) Sodium:solute symporter family
PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain
PF01590 (4/6) GAF domain
PF01593 (3/6) Flavin containing amine oxidoreductase
precursor_groups_66610 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00464 (2/2) Serine hydroxymethyltransferase
precursor_groups_64987 314.08 +- 75.92 2 0 0 0 0.01 +- 0.02 2 7

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF00296 (2/2) Luciferase-like monooxygenase
PF01494 (1/2) FAD binding domain
precursor_groups_54048 150.82 +- 10.42 2 0 0 0 0.06 +- 0.02 2 8

PF16353 (2/2) Domain of unknown function(DUF4981)
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_37792 1233.71 +- 550.62 3 0 0 0 0.01 +- 0.00 3 4

PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_groups_72513 36.07 +- 2.63 2 0 0 0 0.08 +- 0.06 2 8

PF13493 (2/2) Domain of unknown function (DUF4118)
PF06304 (2/2) Protein of unknown function (DUF1048)
PF03551 (2/2) Transcriptional regulator PadR-like family
PF02702 (2/2) Osmosensitive K+ channel His kinase sensor domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02254 (2/2) TrkA-N domain
PF00582 (2/2) Universal stress protein family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
precursor_groups_9908 114.33 +- 17.12 5 0 0 0 0.11 +- 0.06 5 10

TIGR01382 (5/5) intracellular protease, PfpI family
PF13823 (5/5) Alcohol dehydrogenase GroES-associated
PF09123 (5/5) Domain of unknown function (DUF1931)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF01965 (5/5) DJ-1/PfpI family
PF00248 (5/5) Aldo/keto reductase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF13515 (4/5) Fusaric acid resistance protein-like
PF12805 (4/5) FUSC-like inner membrane protein yccS
precursor_groups_28453 234.00 +- 26.00 2 0 0 2 0.01 +- 0.01 2 5

TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
precursor_groups_65221 266.60 +- 8.60 2 0 0 0 0.03 +- 0.03 2 5

PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04191 (2/2) Phospholipid methyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_23791 204.23 +- 0.06 2 0 0 2 0.10 +- 0.29 2 11

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR01343 (2/2) homoaconitate hydratase family protein
TIGR00049 (2/2) iron-sulfur cluster assembly accessory protein
PF08241 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF01521 (2/2) Iron-sulphur cluster biosynthesis
PF01106 (2/2) NifU-like domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_1204 81.78 +- 24.38 26 0 0 0 0.20 +- 0.32 26 11

TIGR03177 (26/26) Flp pilus assembly protein CpaB
PF16976 (26/26) Flp pilus assembly protein RcpC/CpaB
PF07811 (26/26) TadE-like protein
PF00691 (26/26) OmpA family
PF00482 (26/26) Type II secretion system (T2SS), protein F
PF00437 (26/26) Type II/IV secretion system protein
PF13614 (25/26) AAA domain
PF13400 (22/26) Putative Flp pilus-assembly TadE/G-like
PF00196 (21/26) Bacterial regulatory proteins, luxR family
PF00072 (21/26) Response regulator receiver domain
PF07730 (20/26) Histidine kinase
precursor_groups_23796 60.41 +- 43.59 2 0 2 1 0.13 +- 0.20 2 9

TIGR00842 (1/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF13411 (1/2) MerR HTH family regulatory protein
PF08534 (1/2) Redoxin
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02028 (1/2) BCCT, betaine/carnitine/choline family transporter
PF00722 (1/2) Glycosyl hydrolases family 16
PF00106 (1/2) short chain dehydrogenase
PF00069 (1/2) Protein kinase domain
precursor_groups_23065 519.03 +- 169.70 5 0 5 0 0.02 +- 0.02 5 16

TIGR02151 (5/5) isopentenyl-diphosphate delta-isomerase, type 2
TIGR01835 (5/5) hydroxymethylglutaryl-CoA synthase
TIGR01240 (5/5) diphosphomevalonate decarboxylase
TIGR01220 (5/5) phosphomevalonate kinase
TIGR00549 (5/5) mevalonate kinase
PF18376 (5/5) Mevalonate 5-diphosphate decarboxylase C-terminal domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08544 (5/5) GHMP kinases C terminal
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08540 (5/5) Hydroxymethylglutaryl-coenzyme A synthase C terminal
PF01593 (5/5) Flavin containing amine oxidoreductase
PF01154 (5/5) Hydroxymethylglutaryl-coenzyme A synthase N terminal
PF01070 (5/5) FMN-dependent dehydrogenase
PF00368 (5/5) Hydroxymethylglutaryl-coenzyme A reductase
PF00348 (5/5) Polyprenyl synthetase
PF00288 (5/5) GHMP kinases N terminal domain
precursor_groups_11674 89.07 +- 17.09 8 0 8 0 0.03 +- 0.04 8 3

PF01965 (8/8) DJ-1/PfpI family
PF00248 (8/8) Aldo/keto reductase family
PF00106 (8/8) short chain dehydrogenase
precursor_groups_26303 145.53 +- 112.47 2 0 0 0 0.05 +- 0.18 2 13

PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14588 (2/2) YjgF/chorismate_mutase-like, putative endoribonuclease
PF14336 (2/2) Domain of unknown function (DUF4392)
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07005 (2/2) Sugar-binding N-terminal domain
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF17203 (1/2) Single cache domain 3
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13188 (1/2) PAS domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01590 (1/2) GAF domain
precursor_groups_86395 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_86397 61.09 +- 32.05 2 0 0 2 0.12 +- 0.18 2 12

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF08962 (2/2) Domain of unknown function (DUF1876)
PF08940 (2/2) Domain of unknown function (DUF1918)
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF00881 (2/2) Nitroreductase family
PF17203 (1/2) Single cache domain 3
PF13581 (1/2) Histidine kinase-like ATPase domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01590 (1/2) GAF domain
precursor_groups_69002 2858.53 +- 2313.20 2 0 2 0 0.03 +- 0.15 2 27

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13579 (2/2) Glycosyl transferase 4-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04909 (2/2) Amidohydrolase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02449 (2/2) Beta-galactosidase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01180 (2/2) Dihydroorotate dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_groups_8746 140.66 +- 30.94 2 0 0 0 0.11 +- 0.11 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12802 (2/2) MarR family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_35243 65.49 +- 10.34 2 0 0 0 0.19 +- 0.20 2 5

PF14273 (2/2) Domain of unknown function (DUF4360)
PF14016 (2/2) Protein of unknown function (DUF4232)
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01925 (2/2) Sulfite exporter TauE/SafE
precursor_groups_81598 176.62 +- 9.09 2 0 0 0 0.11 +- 0.04 2 6

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_15352 201.33 +- 81.56 3 0 0 0 0.01 +- 0.01 3 4

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF00092 (3/3) von Willebrand factor type A domain
precursor_groups_61068 180.30 +- 87.44 2 0 0 0 0.07 +- 0.14 2 12

PF07730 (2/2) Histidine kinase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF03008 (2/2) Archaea bacterial proteins of unknown function
PF02687 (2/2) FtsX-like permease family
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF13424 (1/2) Tetratricopeptide repeat
PF13176 (1/2) Tetratricopeptide repeat
PF00931 (1/2) NB-ARC domain
precursor_groups_99 474.13 +- 408.65 3 0 0 0 0.02 +- 0.03 3 1

PF00135 (2/3) Carboxylesterase family
precursor_groups_44270 87.00 +- 33.00 2 0 1 0 0.11 +- 0.12 2 14

PF13183 (2/2) 4Fe-4S dicluster domain
PF07063 (2/2) Domain of unknown function (DUF1338)
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF04471 (2/2) Restriction endonuclease
PF04191 (2/2) Phospholipid methyltransferase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02754 (2/2) Cysteine-rich domain
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01968 (2/2) Hydantoinase/oxoprolinase
PF01565 (2/2) FAD binding domain
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
precursor_groups_11072 31.98 +- 4.01 4 0 0 0 0.13 +- 0.07 4 10

TIGR01217 (4/4) acetoacetate-CoA ligase
PF16177 (4/4) Acetyl-coenzyme A synthetase N-terminus
PF13564 (4/4) DoxX-like family
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (4/4) FAD binding domain
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (4/4) AMP-binding enzyme
PF13613 (2/4) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (2/4) DDE superfamily endonuclease
precursor_groups_81753 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
precursor_groups_15593 212.77 +- 130.96 3 0 0 0 0.08 +- 0.11 3 19

TIGR03668 (3/3) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (3/3) probable F420-dependent oxidoreductase, Rv2161c family
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13529 (3/3) Peptidase_C39 like family
PF03547 (3/3) Membrane transport protein
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
TIGR02980 (2/3) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF12697 (2/3) Alpha/beta hydrolase family
PF07729 (2/3) FCD domain
PF06684 (2/3) Amino acid synthesis
PF04545 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
PF04539 (2/3) Sigma-70 region 3
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00171 (2/3) Aldehyde dehydrogenase family
precursor_groups_10071 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
precursor_groups_60518 91.96 +- 41.21 2 0 2 0 0.08 +- 0.21 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF00484 (2/2) Carbonic anhydrase
PF00916 (1/2) Sulfate permease family
precursor_groups_10077 193.83 +- 19.72 3 0 1 0 0.05 +- 0.03 3 5

PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_81759 24.96 +- 6.24 2 0 0 0 0.18 +- 0.33 2 4

PF06259 (2/2) Alpha/beta hydrolase
PF01569 (2/2) PAP2 superfamily
PF01464 (2/2) Transglycosylase SLT domain
PF00877 (2/2) NlpC/P60 family
precursor_groups_10075 25.41 +- 6.29 2 0 0 0 0.08 +- 0.08 2 5

TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF04978 (2/2) Protein of unknown function (DUF664)
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
precursor_groups_73123 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_666 74.48 +- 19.04 5 0 0 0 0.13 +- 0.22 5 8

TIGR01217 (3/5) acetoacetate-CoA ligase
PF16177 (3/5) Acetyl-coenzyme A synthetase N-terminus
PF13564 (3/5) DoxX-like family
PF13193 (3/5) AMP-binding enzyme C-terminal domain
PF01557 (3/5) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/5) FAD binding domain
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (3/5) AMP-binding enzyme
precursor_groups_33094 14.88 +- 0.00 2 0 0 0 0.20 +- 0.05 2 6

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF03466 (2/2) LysR substrate binding domain
PF02803 (2/2) Thiolase, C-terminal domain
PF01575 (2/2) MaoC like domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00108 (2/2) Thiolase, N-terminal domain
precursor_groups_44872 645.00 +- 0.00 3 0 3 0 0.01 +- 0.00 3 10

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF04101 (3/3) Glycosyltransferase family 28 C-terminal domain
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03023 (3/3) Lipid II flippase MurJ
PF02397 (3/3) Bacterial sugar transferase
PF01522 (3/3) Polysaccharide deacetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_66261 56.96 +- 8.04 2 0 0 0 0.22 +- 0.22 2 11

TIGR00797 (2/2) MATE efflux family protein
PF13407 (2/2) Periplasmic binding protein domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
PF00156 (1/2) Phosphoribosyl transferase domain
precursor_groups_1110 647.20 +- 775.68 45 6 39 45 0.07 +- 0.21 39 12

PF13471 (45/45) Transglutaminase-like superfamily
PF05402 (45/45) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (45/45) Asparagine synthase
PF00005 (43/45) ABC transporter
PF01061 (39/45) ABC-2 type transporter
PF12730 (34/45) ABC-2 family transporter protein
PF13462 (33/45) Thioredoxin
PF09587 (31/45) Bacterial capsule synthesis protein PGA_cap
PF07730 (27/45) Histidine kinase
PF07291 (27/45) Methylamine utilisation protein MauE
PF00196 (25/45) Bacterial regulatory proteins, luxR family
PF00072 (25/45) Response regulator receiver domain
precursor_groups_10870 161.01 +- 33.93 3 0 3 0 0.03 +- 0.04 3 8

PF13649 (3/3) Methyltransferase domain
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF07730 (2/3) Histidine kinase
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
precursor_groups_8167 203.37 +- 116.35 8 0 6 8 0.06 +- 0.15 8 9

PF04055 (8/8) Radical SAM superfamily
PF07690 (6/8) Major Facilitator Superfamily
PF00069 (6/8) Protein kinase domain
PF02627 (5/8) Carboxymuconolactone decarboxylase family
PF00583 (5/8) Acetyltransferase (GNAT) family
PF00144 (5/8) Beta-lactamase
PF13472 (4/8) GDSL-like Lipase/Acylhydrolase family
PF06094 (4/8) Gamma-glutamyl cyclotransferase, AIG2-like
PF01113 (4/8) Dihydrodipicolinate reductase, N-terminus
precursor_groups_29676 675.26 +- 414.40 4 0 4 0 0.03 +- 0.12 4 20

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01198 (4/4) 6-phosphogluconolactonase
PF17668 (4/4) Acetyltransferase (GNAT) domain
PF13530 (4/4) Sterol carrier protein domain
PF13527 (4/4) Acetyltransferase (GNAT) domain
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08544 (4/4) GHMP kinases C terminal
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF02709 (4/4) N-terminal domain of galactosyltransferase
PF01761 (4/4) 3-dehydroquinate synthase
PF01182 (4/4) Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00834 (4/4) Ribulose-phosphate 3 epimerase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00293 (4/4) NUDIX domain
PF00288 (4/4) GHMP kinases N terminal domain
PF07676 (3/4) WD40-like Beta Propeller Repeat
PF01979 (3/4) Amidohydrolase family
precursor_groups_62573 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_20466 1035.36 +- 778.90 4 0 4 0 0.03 +- 0.13 4 18

TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_39120 107.61 +- 33.61 3 0 0 0 0.03 +- 0.01 3 4

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
precursor_groups_4180 112.26 +- 31.29 8 0 0 0 0.17 +- 0.09 8 4

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF10091 (8/8) Putative glucoamylase
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00232 (8/8) Glycosyl hydrolase family 1
precursor_groups_5560 18.85 +- 1.99 2 0 1 0 0.19 +- 0.15 2 16

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR01722 (1/2) methylmalonate-semialdehyde dehydrogenase (acylating)
TIGR01692 (1/2) 3-hydroxyisobutyrate dehydrogenase
PF16113 (1/2) Enoyl-CoA hydratase/isomerase
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14478 (1/2) Domain of unknown function (DUF4430)
PF12323 (1/2) Helix-turn-helix domain
PF07282 (1/2) Putative transposase DNA-binding domain
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF01638 (1/2) HxlR-like helix-turn-helix
PF01385 (1/2) Probable transposase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00005 (1/2) ABC transporter
precursor_groups_27300 54.52 +- 20.40 4 0 0 0 0.04 +- 0.02 4 3

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF00501 (4/4) AMP-binding enzyme
PF00221 (4/4) Aromatic amino acid lyase
precursor_groups_34844 24.55 +- 3.14 3 0 0 0 0.17 +- 0.15 3 8

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF17801 (3/3) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (3/3) Alpha galactosidase A
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF07944 (3/3) Beta-L-arabinofuranosidase, GH127
PF05270 (3/3) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03664 (3/3) Glycosyl hydrolase family 62
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_groups_9583 375.66 +- 254.28 4 0 0 0 0.04 +- 0.16 4 4

PF17914 (4/4) HopA1 effector protein family
PF13649 (4/4) Methyltransferase domain
PF02441 (4/4) Flavoprotein
PF01636 (2/4) Phosphotransferase enzyme family
precursor_groups_625 68.03 +- 43.74 3 0 1 0 0.08 +- 0.22 3

No common domains found
precursor_groups_8293 57.50 +- 6.05 4 0 0 4 0.11 +- 0.12 4 6

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF13565 (4/4) Homeodomain-like domain
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF02954 (4/4) Bacterial regulatory protein, Fis family
PF01590 (4/4) GAF domain
PF00733 (4/4) Asparagine synthase
precursor_groups_10413 209.52 +- 69.97 3 0 0 0 0.01 +- 0.01 3 3

TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF04072 (3/3) Leucine carboxyl methyltransferase
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_34848 54.12 +- 15.76 2 0 2 0 0.19 +- 0.31 2 15

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1592 272.42 +- 178.97 19 0 4 0 0.04 +- 0.12 19 4

PF00005 (19/19) ABC transporter
PF00717 (18/19) Peptidase S24-like
PF07291 (16/19) Methylamine utilisation protein MauE
PF00578 (11/19) AhpC/TSA family
precursor_groups_34519 256.85 +- 68.15 2 0 0 0 0.04 +- 0.05 2 5

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_20867 24.24 +- 7.21 4 0 0 0 0.22 +- 0.08 4 8

TIGR01234 (4/4) ribulokinase
PF13377 (4/4) Periplasmic binding protein-like domain
PF11762 (4/4) L-arabinose isomerase C-terminal domain
PF02782 (4/4) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (4/4) L-arabinose isomerase
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain
precursor_groups_14774 49.23 +- 20.12 3 0 0 0 0.11 +- 0.09 3 5

PF08220 (3/3) DeoR-like helix-turn-helix domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (3/3) DeoR C terminal sensor domain
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_77109 21.30 +- 0.66 2 0 0 0 0.09 +- 0.13 2 5

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_groups_14776 21.00 +- 4.97 3 0 2 0 0.10 +- 0.09 3 3

PF13564 (3/3) DoxX-like family
PF07883 (3/3) Cupin domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_groups_83443 79.47 +- 31.10 2 0 0 0 0.04 +- 0.03 2 4

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (2/2) UTRA domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_31674 148.57 +- 74.71 4 0 0 0 0.02 +- 0.04 4 6

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03919 (4/4) type VII secretion protein EccB
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (3/4) type VII secretion integral membrane protein EccD
PF08817 (3/4) WXG100 protein secretion system (Wss), protein YukD
precursor_groups_4056 126.26 +- 39.60 2 0 0 0 0.02 +- 0.01 2 3

PF05995 (2/2) Cysteine dioxygenase type I
PF00581 (2/2) Rhodanese-like domain
PF06094 (1/2) Gamma-glutamyl cyclotransferase, AIG2-like
precursor_groups_597 111.01 +- 32.01 2 0 0 0 0.10 +- 0.25 2 42

TIGR02241 (2/2) conserved hypothetical phage tail region protein
PF17482 (2/2) Phage tail sheath C-terminal domain
PF09684 (2/2) Phage tail protein (Tail_P2_I)
PF06841 (2/2) T4-like virus tail tube protein gp19
PF05488 (2/2) PAAR motif
PF04984 (2/2) Phage tail sheath protein subtilisin-like domain
PF04965 (2/2) Gene 25-like lysozyme
TIGR02243 (1/2) putative baseplate assembly protein
TIGR02242 (1/2) phage tail protein domain
TIGR01910 (1/2) peptidase, ArgE/DapE family
TIGR01828 (1/2) pyruvate, phosphate dikinase
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF14427 (1/2) Pput_2613-like deaminase
PF14065 (1/2) Protein of unknown function (DUF4255)
PF13699 (1/2) Domain of unknown function (DUF4157)
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13378 (1/2) Enolase C-terminal domain-like
PF08962 (1/2) Domain of unknown function (DUF1876)
PF07729 (1/2) FCD domain
PF05954 (1/2) Phage late control gene D protein (GPD)
PF04865 (1/2) Baseplate J-like protein
PF03995 (1/2) Peptidase inhibitor family I36
PF03447 (1/2) Homoserine dehydrogenase, NAD binding domain
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01476 (1/2) LysM domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01321 (1/2) Creatinase/Prolidase N-terminal domain
PF01042 (1/2) Endoribonuclease L-PSP
PF01025 (1/2) GrpE
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00742 (1/2) Homoserine dehydrogenase
PF00557 (1/2) Metallopeptidase family M24
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00012 (1/2) Hsp70 protein
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_1573 302.48 +- 82.04 14 0 14 14 0.01 +- 0.01 14 3

PF13471 (14/14) Transglutaminase-like superfamily
PF13302 (14/14) Acetyltransferase (GNAT) domain
PF00733 (14/14) Asparagine synthase
precursor_groups_13688 551.25 +- 228.75 2 0 0 0 0.03 +- 0.07 2 15

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF04444 (2/2) Catechol dioxygenase N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00501 (2/2) AMP-binding enzyme
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00041 (2/2) Fibronectin type III domain
precursor_groups_20263 344.00 +- 121.62 3 0 0 0 0.01 +- 0.01 3 6

TIGR01356 (3/3) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01141 (3/3) histidinol-phosphate transaminase
PF01613 (3/3) Flavin reductase like domain
PF00275 (3/3) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_17191 142.35 +- 168.39 6 0 0 6 0.03 +- 0.01 6 4

PF13480 (6/6) Acetyltransferase (GNAT) domain
PF04055 (6/6) Radical SAM superfamily
PF02492 (6/6) CobW/HypB/UreG, nucleotide-binding domain
PF13847 (5/6) Methyltransferase domain
precursor_groups_23 106.10 +- 193.75 28 0 4 1 0.14 +- 0.28 28 3

PF00403 (26/28) Heavy-metal-associated domain
PF03965 (17/28) Penicillinase repressor
PF01435 (17/28) Peptidase family M48
precursor_groups_20 77.74 +- 44.16 12 0 0 0 0.15 +- 0.28 12 14

PF13354 (9/12) Beta-lactamase enzyme family
PF09423 (9/12) PhoD-like phosphatase
PF08402 (9/12) TOBE domain
PF02826 (9/12) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00005 (9/12) ABC transporter
TIGR03083 (8/12) uncharacterized Actinobacterial protein TIGR03083
PF13581 (8/12) Histidine kinase-like ATPase domain
PF09339 (8/12) IclR helix-turn-helix domain
PF02894 (8/12) Oxidoreductase family, C-terminal alpha/beta domain
PF01614 (8/12) Bacterial transcriptional regulator
PF01408 (8/12) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (8/12) Binding-protein-dependent transport system inner membrane component
PF01547 (6/12) Bacterial extracellular solute-binding protein
PF01370 (6/12) NAD dependent epimerase/dehydratase family
precursor_groups_2735 65.30 +- 30.67 29 0 29 0 0.10 +- 0.09 29 5

PF07690 (29/29) Major Facilitator Superfamily
PF02826 (29/29) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (29/29) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (29/29) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (29/29) Histidine phosphatase superfamily (branch 1)
precursor_groups_64438 432.28 +- 0.00 2 0 2 0 0.05 +- 0.12 2 20

TIGR01733 (2/2) amino acid adenylation domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF05050 (2/2) Methyltransferase FkbM domain
PF03621 (2/2) MbtH-like protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_63744 354.22 +- 42.22 2 0 0 0 0.05 +- 0.07 2 22

TIGR01552 (2/2) prevent-host-death family protein
TIGR00663 (2/2) DNA polymerase III, beta subunit
TIGR00348 (2/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/2) SWI2/SNF2 ATPase
PF13476 (2/2) AAA domain
PF13304 (2/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (2/2) HsdM N-terminal domain
PF11867 (2/2) Domain of unknown function (DUF3387)
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF05016 (2/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF04073 (2/2) Aminoacyl-tRNA editing domain
PF02768 (2/2) DNA polymerase III beta subunit, C-terminal domain
PF02767 (2/2) DNA polymerase III beta subunit, central domain
PF02604 (2/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02384 (2/2) N-6 DNA Methylase
PF02274 (2/2) Amidinotransferase
PF01565 (2/2) FAD binding domain
PF01420 (2/2) Type I restriction modification DNA specificity domain
PF00712 (2/2) DNA polymerase III beta subunit, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_64434 18.30 +- 0.96 2 0 0 0 0.19 +- 0.05 2 12

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13478 (2/2) XdhC Rossmann domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_groups_49418 271.23 +- 126.83 2 0 2 0 0.13 +- 0.29 2 23

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF14759 (2/2) Reductase C-terminal
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08241 (2/2) Methyltransferase domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07977 (2/2) FabA-like domain
PF04073 (2/2) Aminoacyl-tRNA editing domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01323 (2/2) DSBA-like thioredoxin domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
precursor_groups_5695 22.01 +- 5.59 6 0 5 0 0.17 +- 0.21 6 7

PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF11991 (5/6) Tryptophan dimethylallyltransferase
PF01212 (5/6) Beta-eliminating lyase
PF00383 (5/6) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_1379 94.10 +- 71.16 2 0 1 1 0.11 +- 0.16 2 17

TIGR02243 (1/2) putative baseplate assembly protein
TIGR02241 (1/2) conserved hypothetical phage tail region protein
PF17482 (1/2) Phage tail sheath C-terminal domain
PF14065 (1/2) Protein of unknown function (DUF4255)
PF13699 (1/2) Domain of unknown function (DUF4157)
PF09335 (1/2) SNARE associated Golgi protein
PF06841 (1/2) T4-like virus tail tube protein gp19
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04984 (1/2) Phage tail sheath protein subtilisin-like domain
PF04965 (1/2) Gene 25-like lysozyme
PF04865 (1/2) Baseplate J-like protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00664 (1/2) ABC transporter transmembrane region
PF00248 (1/2) Aldo/keto reductase family
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_5697 156.45 +- 78.58 10 0 0 0 0.10 +- 0.14 10 11

PF00583 (10/10) Acetyltransferase (GNAT) family
TIGR01726 (9/10) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF01244 (9/10) Membrane dipeptidase (Peptidase family M19)
PF00528 (9/10) Binding-protein-dependent transport system inner membrane component
PF00497 (9/10) Bacterial extracellular solute-binding proteins, family 3
PF00005 (9/10) ABC transporter
TIGR00976 (8/10) hydrolase CocE/NonD family protein
PF08530 (8/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/10) X-Pro dipeptidyl-peptidase (S15 family)
PF00296 (7/10) Luciferase-like monooxygenase
PF07690 (5/10) Major Facilitator Superfamily
precursor_groups_59389 61.28 +- 3.22 2 0 0 0 0.05 +- 0.03 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_82223 156.47 +- 81.68 2 0 1 0 0.05 +- 0.11 2 8

PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF13586 (1/2) Transposase DDE domain
PF02899 (1/2) Phage integrase, N-terminal SAM-like domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00589 (1/2) Phage integrase family
PF00152 (1/2) tRNA synthetases class II (D, K and N)
precursor_groups_84589 1418.40 +- 661.60 2 0 0 0 0.01 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_12123 297.07 +- 55.19 2 0 2 0 0.03 +- 0.03 2 12

TIGR01733 (1/2) amino acid adenylation domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF11066 (1/2) Protein of unknown function (DUF2867)
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01494 (1/2) FAD binding domain
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00106 (1/2) short chain dehydrogenase
precursor_groups_32144 17.66 +- 2.35 3 0 0 0 0.12 +- 0.15 3 3

PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01427 (3/3) D-ala-D-ala dipeptidase
PF00795 (3/3) Carbon-nitrogen hydrolase
precursor_groups_13515 271.96 +- 284.05 3 0 2 0 0.05 +- 0.07 3 7

TIGR04539 (2/3) tRNA-dependent cyclodipeptide synthase
TIGR00654 (2/3) phenazine biosynthesis protein, PhzF family
PF16715 (2/3) Cyclodipeptide synthase
PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family
PF02567 (2/3) Phenazine biosynthesis-like protein
PF00144 (2/3) Beta-lactamase
PF00067 (2/3) Cytochrome P450
precursor_groups_941 56.09 +- 86.01 11 0 0 0 0.14 +- 0.23 11 1

PF00583 (11/11) Acetyltransferase (GNAT) family
precursor_groups_85503 25.20 +- 1.80 2 0 0 0 0.12 +- 0.09 2 4

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08534 (2/2) Redoxin
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
precursor_groups_21229 1128.80 +- 378.64 5 0 0 0 0.01 +- 0.00 5 9

PF14525 (5/5) AraC-binding-like domain
PF12833 (5/5) Helix-turn-helix domain
PF11716 (5/5) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF01613 (5/5) Flavin reductase like domain
PF00296 (5/5) Luciferase-like monooxygenase
PF12680 (4/5) SnoaL-like domain
PF02653 (4/5) Branched-chain amino acid transport system / permease component
PF00005 (4/5) ABC transporter
precursor_groups_48827 390.00 +- 130.00 2 0 2 0 0.02 +- 0.01 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00106 (2/2) short chain dehydrogenase
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF06249 (1/2) Ethanolamine utilisation protein EutQ
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (1/2) Flavin reductase like domain
PF01425 (1/2) Amidase
precursor_groups_64500 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_63224 59.40 +- 33.21 2 0 2 0 0.10 +- 0.17 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_groups_21227 70.91 +- 55.01 3 0 0 0 0.13 +- 0.16 3 9

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12697 (2/3) Alpha/beta hydrolase family
PF07690 (2/3) Major Facilitator Superfamily
PF03625 (2/3) Domain of unknown function DUF302
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00106 (2/3) short chain dehydrogenase
PF00072 (2/3) Response regulator receiver domain
PF00027 (2/3) Cyclic nucleotide-binding domain
precursor_groups_17682 104.90 +- 45.10 2 0 1 0 0.09 +- 0.23 2 14

PF00501 (2/2) AMP-binding enzyme
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
PF14696 (1/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF03621 (1/2) MbtH-like protein
PF01614 (1/2) Bacterial transcriptional regulator
PF01144 (1/2) Coenzyme A transferase
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00550 (1/2) Phosphopantetheine attachment site
PF00155 (1/2) Aminotransferase class I and II
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
precursor_groups_33636 44.72 +- 0.49 2 0 0 0 0.13 +- 0.21 2 2

PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
precursor_groups_84877 1148.36 +- 915.64 2 0 2 0 0.04 +- 0.17 2 21

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_85110 73.50 +- 30.50 2 0 0 0 0.06 +- 0.05 2 3

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_2276 448.45 +- 358.44 2 0 0 0 0.13 +- 0.23 2 27

TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00193 (1/2) urease, gamma subunit
TIGR00192 (1/2) urease, beta subunit
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13460 (1/2) NAD(P)H-binding
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF04954 (1/2) Siderophore-interacting protein
PF04371 (1/2) Porphyromonas-type peptidyl-arginine deiminase
PF03704 (1/2) Bacterial transcriptional activator domain
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01979 (1/2) Amidohydrolase family
PF01638 (1/2) HxlR-like helix-turn-helix
PF01425 (1/2) Amidase
PF01037 (1/2) Lrp/AsnC ligand binding domain
PF00699 (1/2) Urease beta subunit
PF00547 (1/2) Urease, gamma subunit
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00449 (1/2) Urease alpha-subunit, N-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00135 (1/2) Carboxylesterase family
PF00005 (1/2) ABC transporter
precursor_groups_2906 679.88 +- 674.03 5 0 0 5 0.02 +- 0.02 5 6

TIGR00702 (5/5) YcaO-type kinase domain
PF07812 (5/5) TfuA-like protein
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF13649 (4/5) Methyltransferase domain
PF07479 (4/5) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF01210 (4/5) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
precursor_groups_39151 56.49 +- 37.65 2 0 0 0 0.08 +- 0.11 2 5

PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08357 (2/2) SEFIR domain
PF00348 (2/2) Polyprenyl synthetase
PF13676 (1/2) TIR domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
precursor_groups_2272 260.57 +- 295.83 11 0 11 11 0.06 +- 0.13 11 9

TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
PF07690 (10/11) Major Facilitator Superfamily
PF02873 (10/11) UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
PF01565 (10/11) FAD binding domain
PF02826 (7/11) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01070 (7/11) FMN-dependent dehydrogenase
precursor_groups_84878 82.79 +- 47.21 2 0 2 0 0.04 +- 0.02 2 4

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (2/2) FMN-dependent dehydrogenase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00067 (2/2) Cytochrome P450
precursor_groups_39152 55.87 +- 1.39 3 0 0 0 0.18 +- 0.13 3 10

PF13646 (3/3) HEAT repeats
PF12838 (3/3) 4Fe-4S dicluster domain
PF09084 (3/3) NMT1/THI5 like
PF07702 (3/3) UTRA domain
PF02910 (3/3) Fumarate reductase flavoprotein C-term
PF01797 (3/3) Transposase IS200 like
PF00890 (3/3) FAD binding domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
precursor_groups_449 114.27 +- 17.27 3 0 3 0 0.06 +- 0.13 3 8

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
TIGR01534 (2/3) glyceraldehyde-3-phosphate dehydrogenase, type I
PF13450 (2/3) NAD(P)-binding Rossmann-like domain
PF02800 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_67680 143.83 +- 48.57 2 0 2 0 0.12 +- 0.22 2 28

TIGR01733 (2/2) amino acid adenylation domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12704 (2/2) MacB-like periplasmic core domain
PF03621 (2/2) MbtH-like protein
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF13191 (1/2) AAA ATPase domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02797 (1/2) Chalcone and stilbene synthases, C-terminal domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02195 (1/2) ParB-like nuclease domain
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00195 (1/2) Chalcone and stilbene synthases, N-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00072 (1/2) Response regulator receiver domain
PF00067 (1/2) Cytochrome P450
precursor_groups_119 46.84 +- 21.17 15 0 0 2 0.11 +- 0.17 15

No common domains found
precursor_groups_118 121.24 +- 94.51 14 0 4 0 0.18 +- 0.25 14 11

PF07690 (14/14) Major Facilitator Superfamily
PF11975 (10/14) Family 4 glycosyl hydrolase C-terminal domain
PF08376 (10/14) Nitrate and nitrite sensing
PF05331 (10/14) Protein of unknown function (DUF742)
PF03259 (10/14) Roadblock/LC7 domain
PF02518 (10/14) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02056 (10/14) Family 4 glycosyl hydrolase
PF01547 (10/14) Bacterial extracellular solute-binding protein
PF00528 (10/14) Binding-protein-dependent transport system inner membrane component
PF00294 (10/14) pfkB family carbohydrate kinase
PF03537 (8/14) Glycoside-hydrolase family GH114
precursor_groups_117 85.78 +- 177.02 123 0 3 0 0.17 +- 0.32 123 7

PF14029 (123/123) Protein of unknown function (DUF4244)
PF00482 (123/123) Type II secretion system (T2SS), protein F
PF00437 (89/123) Type II/IV secretion system protein
TIGR03819 (87/123) helicase/secretion neighborhood ATPase
TIGR03815 (86/123) helicase/secretion neighborhood CpaE-like protein
TIGR03816 (81/123) helicase/secretion neighborhood TadE-like protein
PF13400 (66/123) Putative Flp pilus-assembly TadE/G-like
precursor_groups_444 62.01 +- 10.45 6 0 0 0 0.12 +- 0.21 6 5

PF17964 (6/6) Bacterial Ig domain
PF03734 (6/6) L,D-transpeptidase catalytic domain
PF02687 (6/6) FtsX-like permease family
PF00082 (6/6) Subtilase family
PF00005 (6/6) ABC transporter
precursor_groups_36350 597.28 +- 327.05 3 0 0 0 0.03 +- 0.03 3 17

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (3/3) tRNA synthetases class I (M)
PF08031 (3/3) Berberine and berberine like
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07883 (3/3) Cupin domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02274 (3/3) Amidinotransferase
PF01613 (3/3) Flavin reductase like domain
PF01565 (3/3) FAD binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF07690 (2/3) Major Facilitator Superfamily
PF05425 (2/3) Copper resistance protein D
PF04234 (2/3) CopC domain
precursor_groups_446 1815.67 +- 1879.27 73 0 12 0 0.02 +- 0.08 73 9

PF17914 (73/73) HopA1 effector protein family
PF02441 (72/73) Flavoprotein
PF00675 (72/73) Insulinase (Peptidase family M16)
PF05193 (70/73) Peptidase M16 inactive domain
PF00296 (68/73) Luciferase-like monooxygenase
PF00005 (66/73) ABC transporter
PF00664 (46/73) ABC transporter transmembrane region
PF01636 (39/73) Phosphotransferase enzyme family
PF00891 (37/73) O-methyltransferase domain
precursor_groups_36356 47.85 +- 3.82 3 0 0 0 0.18 +- 0.28 3 10

TIGR03328 (3/3) methylthioribulose-1-phosphate dehydratase
TIGR01691 (3/3) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF09754 (3/3) PAC2 family
PF03079 (3/3) ARD/ARD' family
PF01979 (3/3) Amidohydrolase family
PF01048 (3/3) Phosphorylase superfamily
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF00082 (3/3) Subtilase family
precursor_groups_57389 68.84 +- 20.47 2 0 0 0 0.05 +- 0.06 2 4

TIGR03382 (2/2) Myxococcales GC_trans_RRR domain
PF13285 (2/2) Domain of unknown function (DUF4073)
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_groups_47435 145.36 +- 40.36 2 0 0 0 0.07 +- 0.10 2 9

PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR00218 (1/2) mannose-6-phosphate isomerase, class I
PF03425 (1/2) Carbohydrate binding domain (family 11)
precursor_groups_110 95.39 +- 92.06 5 0 1 0 0.09 +- 0.16 5

No common domains found
precursor_groups_4613 30.88 +- 5.39 2 0 0 0 0.08 +- 0.09 2 10

PF18029 (1/2) Glyoxalase-like domain
PF13546 (1/2) DDE superfamily endonuclease
PF13520 (1/2) Amino acid permease
PF13358 (1/2) DDE superfamily endonuclease
PF04978 (1/2) Protein of unknown function (DUF664)
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00293 (1/2) NUDIX domain
precursor_groups_59657 333.38 +- 53.62 2 0 0 0 0.09 +- 0.04 2 9

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
precursor_groups_39806 181.52 +- 36.96 3 0 1 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_groups_1840 74.98 +- 50.77 10 0 1 0 0.05 +- 0.04 10 2

PF07702 (10/10) UTRA domain
PF13673 (9/10) Acetyltransferase (GNAT) domain
precursor_groups_72298 804.48 +- 177.91 2 0 0 0 0.03 +- 0.03 2 17

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (2/2) tRNA synthetases class I (M)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02274 (2/2) Amidinotransferase
PF01613 (2/2) Flavin reductase like domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
precursor_groups_283 42.23 +- 12.62 22 0 14 0 0.19 +- 0.29 22 5

PF17964 (22/22) Bacterial Ig domain
PF13499 (22/22) EF-hand domain pair
PF03734 (22/22) L,D-transpeptidase catalytic domain
PF01522 (21/22) Polysaccharide deacetylase
PF05425 (14/22) Copper resistance protein D
precursor_groups_26089 65.43 +- 21.35 3 0 0 0 0.05 +- 0.07 3 5

PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF07729 (3/3) FCD domain
PF05448 (3/3) Acetyl xylan esterase (AXE1)
PF01494 (3/3) FAD binding domain
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_280 161.47 +- 132.16 42 0 0 0 0.05 +- 0.10 42 2

PF06737 (42/42) Transglycosylase-like domain
PF01476 (42/42) LysM domain
precursor_groups_85707 99.38 +- 16.84 2 0 0 0 0.10 +- 0.24 2 24

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR02009 (2/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (2/2) Glyoxalase-like domain
PF17866 (2/2) AAA lid domain
PF14436 (2/2) Bacterial EndoU nuclease
PF13560 (2/2) Helix-turn-helix domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF13229 (2/2) Right handed beta helix region
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (2/2) Cupin domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03636 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_21134 18.53 +- 2.74 2 0 1 0 0.13 +- 0.08 2 5

PF04264 (1/2) YceI-like domain
PF03713 (1/2) Domain of unknown function (DUF305)
PF03422 (1/2) Carbohydrate binding module (family 6)
PF01872 (1/2) RibD C-terminal domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_68244 80.32 +- 35.78 2 0 0 0 0.14 +- 0.11 2 4

PF13649 (2/2) Methyltransferase domain
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00872 (1/2) Transposase, Mutator family
precursor_groups_53391 476.58 +- 25.08 2 0 0 0 0.01 +- 0.02 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF01614 (2/2) Bacterial transcriptional regulator
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_59863 839.62 +- 720.38 2 0 2 0 0.06 +- 0.20 2 11

TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (2/2) dihydroorotate dehydrogenase family protein
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF09084 (2/2) NMT1/THI5 like
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF00589 (1/2) Phage integrase family
precursor_groups_30546 19.59 +- 0.00 3 0 0 0 0.15 +- 0.17 3 5

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF04542 (3/3) Sigma-70 region 2
PF04264 (3/3) YceI-like domain
PF01471 (3/3) Putative peptidoglycan binding domain
PF00413 (3/3) Matrixin
precursor_groups_53398 711.64 +- 133.36 2 0 0 0 0.01 +- 0.01 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF10935 (2/2) Protein of unknown function (DUF2637)
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_840 40.82 +- 1.02 2 0 1 0 0.12 +- 0.27 2 10

PF00171 (2/2) Aldehyde dehydrogenase family
PF10935 (1/2) Protein of unknown function (DUF2637)
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF04978 (1/2) Protein of unknown function (DUF664)
PF03928 (1/2) Haem-degrading
PF00668 (1/2) Condensation domain
PF00264 (1/2) Common central domain of tyrosinase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_38778 260.00 +- 0.00 3 0 0 0 0.01 +- 0.00 3 2

PF01738 (3/3) Dienelactone hydrolase family
PF00069 (3/3) Protein kinase domain
precursor_groups_56384 204.45 +- 60.34 2 0 0 0 0.07 +- 0.04 2 11

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF07690 (2/2) Major Facilitator Superfamily
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00146 (2/2) NADH dehydrogenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_45444 151.24 +- 56.75 3 0 3 0 0.03 +- 0.02 3 14

TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF09335 (3/3) SNARE associated Golgi protein
PF08659 (3/3) KR domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_57892 749.45 +- 101.45 2 0 0 0 0.03 +- 0.04 2 11

PF18099 (2/2) DUF5010 C-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF10756 (2/2) Bacterial PH domain
PF03663 (2/2) Glycosyl hydrolase family 76
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00920 (2/2) Dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_38772 451.12 +- 125.20 3 0 2 0 0.03 +- 0.03 3 10

PF14742 (3/3) N-terminal domain of (some) glycogen debranching enzymes
PF10282 (3/3) Lactonase, 7-bladed beta-propeller
PF07883 (3/3) Cupin domain
PF07729 (3/3) FCD domain
PF06202 (3/3) Amylo-alpha-1,6-glucosidase
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF03600 (3/3) Citrate transporter
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_12406 30.93 +- 23.54 6 0 0 0 0.11 +- 0.06 6 4

PF03992 (6/6) Antibiotic biosynthesis monooxygenase
PF00294 (6/6) pfkB family carbohydrate kinase
PF08244 (4/6) Glycosyl hydrolases family 32 C terminal
PF00251 (4/6) Glycosyl hydrolases family 32 N-terminal domain
precursor_groups_30784 150.39 +- 117.30 2 0 0 0 0.12 +- 0.17 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00296 (2/2) Luciferase-like monooxygenase
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (1/2) Major Facilitator Superfamily
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter
precursor_groups_39799 26.74 +- 5.51 2 0 0 0 0.12 +- 0.18 2 6

TIGR03567 (2/2) FMN reductase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF00962 (2/2) Adenosine/AMP deaminase
PF00720 (2/2) Subtilisin inhibitor-like
precursor_groups_79378 58.81 +- 15.48 2 0 2 0 0.18 +- 0.08 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_40542 247.43 +- 142.46 3 0 3 0 0.06 +- 0.16 3 11

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
TIGR01830 (2/3) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/3) Serine aminopeptidase, S33
PF07977 (2/3) FabA-like domain
PF02786 (2/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/3) DSBA-like thioredoxin domain
PF00698 (2/3) Acyl transferase domain
precursor_groups_39970 10.58 +- 0.26 2 0 0 0 0.19 +- 0.06 2 4

TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13202 (2/2) EF hand
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
precursor_groups_47697 67.53 +- 10.99 3 0 0 0 0.12 +- 0.12 3 7

PF18050 (3/3) Cyclophilin-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
precursor_groups_16483 158.04 +- 59.38 3 0 1 0 0.13 +- 0.27 3 26

PF03737 (3/3) Aldolase/RraA
TIGR03221 (2/3) muconolactone delta-isomerase
TIGR02438 (2/3) catechol 1,2-dioxygenase
PF13577 (2/3) SnoaL-like domain
PF13532 (2/3) 2OG-Fe(II) oxygenase superfamily
PF13378 (2/3) Enolase C-terminal domain-like
PF12891 (2/3) Glycoside hydrolase family 44
PF09339 (2/3) IclR helix-turn-helix domain
PF07745 (2/3) Glycosyl hydrolase family 53
PF07690 (2/3) Major Facilitator Superfamily
PF04444 (2/3) Catechol dioxygenase N terminus
PF03466 (2/3) LysR substrate binding domain
PF02746 (2/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02426 (2/3) Muconolactone delta-isomerase
PF01614 (2/3) Bacterial transcriptional regulator
PF01494 (2/3) FAD binding domain
PF01425 (2/3) Amidase
PF00866 (2/3) Ring hydroxylating beta subunit
PF00848 (2/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00775 (2/3) Dioxygenase
PF00553 (2/3) Cellulose binding domain
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00126 (2/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (2/3) short chain dehydrogenase
PF00041 (2/3) Fibronectin type III domain
precursor_groups_29301 64.02 +- 2.74 4 0 0 0 0.12 +- 0.12 4 10

PF13586 (4/4) Transposase DDE domain
PF12802 (4/4) MarR family
PF07690 (4/4) Major Facilitator Superfamily
PF01327 (4/4) Polypeptide deformylase
PF00857 (4/4) Isochorismatase family
PF00106 (4/4) short chain dehydrogenase
TIGR02957 (3/4) RNA polymerase sigma-70 factor, TIGR02957 family
PF12680 (3/4) SnoaL-like domain
PF08281 (3/4) Sigma-70, region 4
PF04542 (3/4) Sigma-70 region 2
precursor_groups_35254 4130.91 +- 755.96 3 0 0 0 0.01 +- 0.01 3 10

PF13814 (3/3) Replication-relaxation
PF13406 (3/3) Transglycosylase SLT domain
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF01476 (2/3) LysM domain
precursor_groups_52867 260.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
precursor_groups_52863 22.89 +- 3.64 2 0 0 0 0.20 +- 0.37 2 7

PF13365 (2/2) Trypsin-like peptidase domain
PF05685 (2/2) Putative restriction endonuclease
PF01569 (2/2) PAP2 superfamily
PF01464 (2/2) Transglycosylase SLT domain
PF00877 (2/2) NlpC/P60 family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF00069 (1/2) Protein kinase domain
precursor_groups_5679 40.83 +- 0.34 2 0 0 0 0.24 +- 0.23 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
PF00005 (2/2) ABC transporter
precursor_groups_25093 120.32 +- 107.16 3 0 0 0 0.06 +- 0.08 3 4

TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03919 (3/3) type VII secretion protein EccB
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_groups_45762 170.38 +- 98.08 2 0 0 0 0.22 +- 0.28 2 19

TIGR00765 (2/2) YihY family inner membrane protein
TIGR00105 (2/2) ribosomal protein bL31
PF11941 (2/2) Domain of unknown function (DUF3459)
PF07705 (2/2) CARDB
PF05922 (2/2) Peptidase inhibitor I9
PF03631 (2/2) Virulence factor BrkB
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (2/2) Acyl-CoA oxidase
PF01497 (2/2) Periplasmic binding protein
PF01197 (2/2) Ribosomal protein L31
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00128 (2/2) Alpha amylase, catalytic domain
PF00082 (2/2) Subtilase family
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01032 (1/2) FecCD transport family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
precursor_groups_17458 96.75 +- 37.21 2 0 0 0 0.05 +- 0.05 2 13

PF17851 (1/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10503 (1/2) Esterase PHB depolymerase
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF04616 (1/2) Glycosyl hydrolases family 43
PF03664 (1/2) Glycosyl hydrolase family 62
PF01120 (1/2) Alpha-L-fucosidase
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00501 (1/2) AMP-binding enzyme
precursor_groups_22265 275.25 +- 71.07 4 0 4 0 0.01 +- 0.00 4 9

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF12680 (4/4) SnoaL-like domain
PF08242 (4/4) Methyltransferase domain
PF07883 (4/4) Cupin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
precursor_groups_39773 182.92 +- 27.92 3 0 3 0 0.17 +- 0.34 3 11

PF13424 (3/3) Tetratricopeptide repeat
PF06259 (3/3) Alpha/beta hydrolase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01757 (3/3) Acyltransferase family
PF01177 (3/3) Asp/Glu/Hydantoin racemase
PF01061 (3/3) ABC-2 type transporter
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_62905 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
precursor_groups_19401 361.87 +- 329.39 4 0 0 0 0.09 +- 0.12 4 7

PF14759 (4/4) Reductase C-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF01047 (4/4) MarR family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
precursor_groups_18428 357.44 +- 206.94 2 0 0 0 0.04 +- 0.05 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF00293 (2/2) NUDIX domain
PF13649 (1/2) Methyltransferase domain
PF08242 (1/2) Methyltransferase domain
PF08241 (1/2) Methyltransferase domain
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF00005 (1/2) ABC transporter
precursor_groups_24025 23.44 +- 7.52 2 0 0 0 0.17 +- 0.16 2 8

PF17754 (2/2) MftR C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08445 (2/2) FR47-like protein
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00005 (1/2) ABC transporter
precursor_groups_53408 45.07 +- 5.68 2 0 0 0 0.10 +- 0.10 2 7

TIGR00879 (2/2) MFS transporter, sugar porter (SP) family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01910 (2/2) Thiamine-binding protein
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
PF06114 (1/2) IrrE N-terminal-like domain
precursor_groups_56167 61.91 +- 6.59 2 0 2 0 0.16 +- 0.10 2 8

TIGR03356 (2/2) beta-galactosidase
PF13802 (2/2) Galactose mutarotase-like
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_78352 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_18420 72.45 +- 38.08 3 0 0 0 0.04 +- 0.05 3 3

PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
precursor_groups_79198 6286.90 +- 4033.10 2 0 2 2 0.02 +- 0.07 2 21

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12698 (2/2) ABC-2 family transporter protein
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_38514 67.53 +- 10.99 3 0 0 0 0.12 +- 0.12 3 7

PF18050 (3/3) Cyclophilin-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
precursor_groups_24302 24.22 +- 3.14 2 0 0 0 0.10 +- 0.05 2 10

PF14759 (2/2) Reductase C-terminal
PF13459 (2/2) 4Fe-4S single cluster domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00067 (2/2) Cytochrome P450
TIGR00229 (1/2) PAS domain S-box protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01590 (1/2) GAF domain
PF00989 (1/2) PAS fold
precursor_groups_55941 62.30 +- 11.98 2 0 0 0 0.07 +- 0.04 2 11

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00108 (2/2) Thiolase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_55947 334.90 +- 12.40 2 0 0 0 0.01 +- 0.02 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01241 (2/2) ATP-dependent metallopeptidase HflB
TIGR00374 (2/2) TIGR00374 family protein
PF17862 (2/2) AAA+ lid domain
PF13649 (2/2) Methyltransferase domain
PF13473 (2/2) Cupredoxin-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06480 (2/2) FtsH Extracellular
PF04945 (2/2) YHS domain
PF03706 (2/2) Lysylphosphatidylglycerol synthase TM region
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01434 (2/2) Peptidase family M41
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00122 (2/2) E1-E2 ATPase
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_17703 890.35 +- 1194.77 3 0 0 0 0.11 +- 0.25 3 5

PF13641 (2/3) Glycosyltransferase like family 2
PF03466 (2/3) LysR substrate binding domain
PF01757 (2/3) Acyltransferase family
PF01522 (2/3) Polysaccharide deacetylase
PF00126 (2/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_62660 902.29 +- 527.71 2 0 1 2 0.04 +- 0.06 2 16

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF04055 (2/2) Radical SAM superfamily
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF01061 (2/2) ABC-2 type transporter
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00160 (2/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00005 (2/2) ABC transporter
PF12006 (1/2) Protein of unknown function (DUF3500)
PF07690 (1/2) Major Facilitator Superfamily
PF06912 (1/2) Protein of unknown function (DUF1275)
PF03737 (1/2) Aldolase/RraA
PF01494 (1/2) FAD binding domain
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_2291 18.72 +- 6.44 2 0 0 0 0.16 +- 0.28 2 12

TIGR01460 (1/2) HAD hydrolase, family IIA
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF13344 (1/2) Haloacid dehalogenase-like hydrolase
PF13242 (1/2) HAD-hyrolase-like
PF12158 (1/2) Protein of unknown function (DUF3592)
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF04203 (1/2) Sortase domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (1/2) SPFH domain / Band 7 family
PF00877 (1/2) NlpC/P60 family
PF00480 (1/2) ROK family
PF00067 (1/2) Cytochrome P450
precursor_groups_11252 123.21 +- 132.14 3 0 3 0 0.06 +- 0.11 3 5

PF13649 (3/3) Methyltransferase domain
PF06276 (3/3) Ferric iron reductase FhuF-like transporter
PF04183 (3/3) IucA / IucC family
PF18616 (2/3) CDI immunity proteins
PF18029 (2/3) Glyoxalase-like domain
precursor_groups_29244 53.78 +- 16.02 3 0 0 0 0.15 +- 0.19 3 6

TIGR00996 (3/3) virulence factor Mce family protein
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
PF13577 (2/3) SnoaL-like domain
precursor_groups_2298 20.00 +- 0.00 2 0 0 0 0.20 +- 0.13 2 9

PF17964 (2/2) Bacterial Ig domain
PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01614 (2/2) Bacterial transcriptional regulator
PF00722 (2/2) Glycosyl hydrolases family 16
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_18339 925.13 +- 606.88 5 0 0 0 0.03 +- 0.05 5 9

TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (5/5) Tetracyclin repressor-like, C-terminal domain
PF14224 (5/5) Domain of unknown function (DUF4331)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF00925 (5/5) GTP cyclohydrolase II
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00107 (5/5) Zinc-binding dehydrogenase
PF04686 (4/5) Streptomyces sporulation and cell division protein, SsgA
precursor_groups_19241 148.40 +- 67.91 5 0 0 0 0.02 +- 0.02 5 3

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_75061 181.17 +- 52.17 2 0 0 0 0.03 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF07179 (1/2) SseB protein N-terminal domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_groups_16037 242.88 +- 28.52 4 0 0 0 0.01 +- 0.00 4 5

TIGR01549 (4/4) HAD hydrolase, family IA, variant 1
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00155 (4/4) Aminotransferase class I and II
precursor_groups_18330 227.00 +- 56.01 4 0 4 0 0.01 +- 0.01 4 2

PF03301 (4/4) Tryptophan 2,3-dioxygenase
PF00891 (4/4) O-methyltransferase domain
precursor_groups_85297 335.57 +- 179.23 2 0 0 0 0.06 +- 0.12 2 14

PF13378 (2/2) Enolase C-terminal domain-like
PF13229 (2/2) Right handed beta helix region
PF05336 (2/2) L-rhamnose mutarotase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02368 (2/2) Bacterial Ig-like domain (group 2)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
PF13551 (1/2) Winged helix-turn helix
PF12708 (1/2) Pectate lyase superfamily protein
PF07729 (1/2) FCD domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00295 (1/2) Glycosyl hydrolases family 28
precursor_groups_10170 100.43 +- 33.38 5 0 0 0 0.06 +- 0.09 5 11

PF18130 (5/5) ATP-grasp N-terminal domain
PF16259 (5/5) Domain of unknown function (DUF4913)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF03771 (5/5) Domain of unknown function (DUF317)
PF01638 (5/5) HxlR-like helix-turn-helix
PF01555 (5/5) DNA methylase
PF17802 (4/5) Prealbumin-like fold domain
TIGR01509 (3/5) HAD hydrolase, family IA, variant 3
PF18603 (3/5) L-amino acid ligase C-terminal domain 2
PF08239 (3/5) Bacterial SH3 domain
precursor_groups_14881 45.88 +- 12.90 3 0 0 0 0.11 +- 0.07 3 8

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_groups_38422 60.28 +- 4.67 2 0 0 0 0.13 +- 0.30 2 4

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03780 (2/2) Asp23 family, cell envelope-related function
precursor_groups_14887 1198.81 +- 944.30 4 0 2 3 0.07 +- 0.15 4 15

TIGR01208 (4/4) glucose-1-phosphate thymidylyltransferase
TIGR01181 (4/4) dTDP-glucose 4,6-dehydratase
PF16363 (4/4) GDP-mannose 4,6 dehydratase
PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00535 (4/4) Glycosyl transferase family 2
PF00483 (4/4) Nucleotidyl transferase
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein
PF13305 (2/4) Tetracyclin repressor-like, C-terminal domain
PF01381 (2/4) Helix-turn-helix
precursor_groups_18685 38.59 +- 7.63 2 0 0 0 0.08 +- 0.05 2 5

TIGR00638 (2/2) molybdenum-pterin binding domain
PF03459 (2/2) TOBE domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF12802 (1/2) MarR family
PF00480 (1/2) ROK family
precursor_groups_10205 260.42 +- 92.40 7 0 0 7 0.04 +- 0.10 7 4

PF04828 (7/7) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (7/7) Amidinotransferase
PF00999 (7/7) Sodium/hydrogen exchanger family
PF00881 (7/7) Nitroreductase family
precursor_groups_32958 56.60 +- 20.75 3 0 0 0 0.12 +- 0.07 3 8

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_5417 635.56 +- 525.44 2 0 1 0 0.04 +- 0.05 2 21

PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF14759 (1/2) Reductase C-terminal
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF05199 (1/2) GMC oxidoreductase
PF04909 (1/2) Amidohydrolase
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00732 (1/2) GMC oxidoreductase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00288 (1/2) GHMP kinases N terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
precursor_groups_17850 45.78 +- 8.17 3 0 0 0 0.04 +- 0.01 3 2

PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
precursor_groups_25413 50.58 +- 19.79 4 0 4 0 0.15 +- 0.30 4 9

TIGR02406 (4/4) diaminobutyrate acetyltransferase
TIGR00556 (4/4) phosphopantetheine--protein transferase domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF06339 (4/4) Ectoine synthase
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
precursor_groups_30765 87.31 +- 0.99 2 0 2 0 0.21 +- 0.36 2 15

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_2122 67.02 +- 20.38 31 0 0 0 0.11 +- 0.06 31 14

PF13561 (31/31) Enoyl-(Acyl carrier protein) reductase
PF12697 (31/31) Alpha/beta hydrolase family
PF07883 (31/31) Cupin domain
PF03447 (31/31) Homoserine dehydrogenase, NAD binding domain
PF02776 (31/31) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (31/31) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01958 (31/31) Domain of unknown function DUF108
PF01042 (31/31) Endoribonuclease L-PSP
PF00903 (31/31) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00355 (31/31) Rieske [2Fe-2S] domain
PF00205 (31/31) Thiamine pyrophosphate enzyme, central domain
PF00175 (31/31) Oxidoreductase NAD-binding domain
PF00171 (31/31) Aldehyde dehydrogenase family
PF00111 (31/31) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_65567 396.06 +- 136.06 2 0 0 0 0.02 +- 0.02 2 9

TIGR00784 (2/2) citrate transporter
PF17874 (2/2) MalT-like TPR region
PF13649 (2/2) Methyltransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03600 (2/2) Citrate transporter
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
precursor_groups_64675 84.21 +- 4.14 2 0 0 0 0.12 +- 0.30 2 8

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00005 (2/2) ABC transporter
precursor_groups_42885 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
precursor_groups_40979 517.33 +- 1.89 3 0 3 3 0.01 +- 0.00 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter
precursor_groups_33892 381.94 +- 45.60 3 0 0 0 0.01 +- 0.01 3 8

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF07690 (3/3) Major Facilitator Superfamily
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_17521 76.28 +- 56.48 3 0 0 0 0.12 +- 0.23 3 12

TIGR01792 (3/3) urease, alpha subunit
TIGR00193 (3/3) urease, gamma subunit
TIGR00192 (3/3) urease, beta subunit
TIGR00101 (3/3) urease accessory protein UreG
PF15531 (3/3) Bacterial toxin 27
PF02492 (3/3) CobW/HypB/UreG, nucleotide-binding domain
PF01979 (3/3) Amidohydrolase family
PF01774 (3/3) UreD urease accessory protein
PF01730 (3/3) UreF
PF00699 (3/3) Urease beta subunit
PF00547 (3/3) Urease, gamma subunit
PF00449 (3/3) Urease alpha-subunit, N-terminal domain
precursor_groups_19089 486.75 +- 211.32 3 0 3 0 0.01 +- 0.01 3 4

PF11706 (3/3) CGNR zinc finger
PF01713 (3/3) Smr domain
PF01596 (3/3) O-methyltransferase
PF01494 (3/3) FAD binding domain
precursor_groups_42527 148.15 +- 33.85 2 0 0 0 0.07 +- 0.03 2 5

PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
precursor_groups_69270 115.86 +- 101.92 2 0 2 0 0.15 +- 0.19 2 15

PF05834 (2/2) Lycopene cyclase protein
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01209 (2/2) ubiE/COQ5 methyltransferase family
PF17677 (1/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF12802 (1/2) MarR family
PF10022 (1/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (1/2) Alpha mannosidase middle domain
PF07748 (1/2) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (1/2) Trehalose utilisation
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (1/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00480 (1/2) ROK family
precursor_groups_38222 37.85 +- 16.33 2 0 0 0 0.18 +- 0.33 2 20

TIGR01484 (2/2) HAD hydrolase, family IIB
PF14378 (2/2) PAP2 superfamily
PF13309 (2/2) HTH domain
PF09957 (2/2) Bacterial antitoxin of type II TA system, VapB
PF08348 (2/2) YheO-like PAS domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF01850 (2/2) PIN domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF13560 (1/2) Helix-turn-helix domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF12972 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF11941 (1/2) Domain of unknown function (DUF3459)
PF06224 (1/2) Winged helix DNA-binding domain
PF05089 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00128 (1/2) Alpha amylase, catalytic domain
PF00072 (1/2) Response regulator receiver domain
precursor_groups_3189 420.14 +- 379.58 7 0 7 0 0.05 +- 0.15 7 4

PF13649 (7/7) Methyltransferase domain
PF12697 (7/7) Alpha/beta hydrolase family
PF00664 (7/7) ABC transporter transmembrane region
PF00005 (7/7) ABC transporter
precursor_groups_38229 149.78 +- 122.74 3 0 3 0 0.06 +- 0.05 3 7

PF13563 (3/3) 2'-5' RNA ligase superfamily
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00535 (3/3) Glycosyl transferase family 2
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_groups_27807 718.71 +- 55.29 2 0 2 2 0.01 +- 0.00 2 6

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_18208 16.83 +- 7.66 3 0 0 0 0.16 +- 0.22 3 3

PF13641 (2/3) Glycosyltransferase like family 2
PF01757 (2/3) Acyltransferase family
PF01522 (2/3) Polysaccharide deacetylase
precursor_groups_18209 318.92 +- 254.42 2 0 0 0 0.03 +- 0.04 2 6

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
PF05922 (2/2) Peptidase inhibitor I9
PF00296 (2/2) Luciferase-like monooxygenase
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
PF00501 (1/2) AMP-binding enzyme
precursor_groups_81565 232.20 +- 77.40 2 0 0 0 0.01 +- 0.01 2 4

PF04266 (2/2) ASCH domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_6119 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF03640 (2/2) Secreted repeat of unknown function
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
precursor_groups_74622 128.36 +- 2.85 2 0 2 0 0.14 +- 0.12 2 6

PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00293 (2/2) NUDIX domain
precursor_groups_72723 440.60 +- 79.40 2 0 0 0 0.01 +- 0.01 2 10

PF16864 (2/2) Dimerisation domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF05423 (2/2) Mycobacterium membrane protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF16655 (1/2) PhoD-like phosphatase, N-terminal domain
PF09423 (1/2) PhoD-like phosphatase
precursor_groups_6113 60.84 +- 66.48 12 0 1 0 0.11 +- 0.15 12 7

TIGR03930 (12/12) WXG100 family type VII secretion target
PF06013 (12/12) Proteins of 100 residues with WXG
PF05108 (12/12) Type VII secretion system ESX-1, transport TM domain B
TIGR03919 (11/12) type VII secretion protein EccB
TIGR03920 (10/12) type VII secretion integral membrane protein EccD
PF08817 (10/12) WXG100 protein secretion system (Wss), protein YukD
PF02575 (8/12) YbaB/EbfC DNA-binding family
precursor_groups_6578 190.07 +- 17.63 3 0 0 0 0.02 +- 0.03 3 6

TIGR03696 (2/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
PF15605 (2/3) Bacterial toxin 28
PF07179 (2/3) SseB protein N-terminal domain
PF05593 (2/3) RHS Repeat
PF04149 (2/3) Domain of unknown function (DUF397)
precursor_groups_22781 213.77 +- 76.76 5 0 0 0 0.02 +- 0.01 5 4

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01713 (5/5) Smr domain
PF00501 (5/5) AMP-binding enzyme
precursor_groups_3048 36.66 +- 20.14 5 0 0 0 0.19 +- 0.27 5 11

TIGR00045 (5/5) glycerate kinase
PF02595 (5/5) Glycerate kinase family
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (5/5) Sodium:sulfate symporter transmembrane region
PF00672 (5/5) HAMP domain
PF00512 (5/5) His Kinase A (phospho-acceptor) domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00072 (5/5) Response regulator receiver domain
PF12867 (4/5) DinB superfamily
PF07690 (4/5) Major Facilitator Superfamily
PF00144 (4/5) Beta-lactamase
precursor_groups_43934 46.64 +- 4.19 2 0 0 0 0.22 +- 0.34 2 5

PF05995 (2/2) Cysteine dioxygenase type I
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_42425 48.87 +- 0.00 2 0 0 0 0.20 +- 0.39 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (2/2) argininosuccinate lyase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07905 (2/2) Purine catabolism regulatory protein-like family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00491 (2/2) Arginase family
PF00206 (2/2) Lyase
PF00005 (2/2) ABC transporter
precursor_groups_378 104.07 +- 111.65 121 0 0 9 0.17 +- 0.15 121 4

PF07811 (121/121) TadE-like protein
PF00482 (121/121) Type II secretion system (T2SS), protein F
PF00437 (121/121) Type II/IV secretion system protein
PF13400 (120/121) Putative Flp pilus-assembly TadE/G-like
precursor_groups_3057 38.48 +- 24.58 26 0 0 0 0.08 +- 0.07 26 3

PF04464 (26/26) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (26/26) Glycosyl transferase family 2
PF00534 (26/26) Glycosyl transferases group 1
precursor_groups_7511 53.79 +- 13.26 5 0 5 0 0.18 +- 0.19 5 24

TIGR00073 (5/5) hydrogenase accessory protein HypB
TIGR00072 (5/5) hydrogenase maturation protease
PF14720 (5/5) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (5/5) Protein of unknown function (DUF4232)
PF07503 (5/5) HypF finger
PF02492 (5/5) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (5/5) Hydrogenase maturation protease
PF01300 (5/5) Telomere recombination
PF01155 (5/5) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (5/5) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (5/5) Acylphosphatase
PF00374 (5/5) Nickel-dependent hydrogenase
TIGR00143 (4/5) carbamoyltransferase HypF
PF17788 (4/5) HypF Kae1-like domain
TIGR02124 (3/5) hydrogenase expression/formation protein HypE
TIGR00075 (3/5) hydrogenase expression/formation protein HypD
TIGR00074 (3/5) hydrogenase assembly chaperone HypC/HupF
PF12833 (3/5) Helix-turn-helix domain
PF12625 (3/5) Arabinose-binding domain of AraC transcription regulator, N-term
PF03583 (3/5) Secretory lipase
PF02769 (3/5) AIR synthase related protein, C-terminal domain
PF01924 (3/5) Hydrogenase formation hypA family
PF01455 (3/5) HupF/HypC family
PF00586 (3/5) AIR synthase related protein, N-terminal domain
precursor_groups_31823 79.96 +- 22.76 2 0 0 1 0.17 +- 0.18 2 8

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03699 (1/2) dehypoxanthine futalosine cyclase
PF04055 (1/2) Radical SAM superfamily
PF03704 (1/2) Bacterial transcriptional activator domain
PF01478 (1/2) Type IV leader peptidase family
precursor_groups_12647 15.20 +- 5.33 2 0 2 0 0.15 +- 0.16 2 3

TIGR02434 (2/2) precorrin-6A synthase (deacetylating)
PF03745 (2/2) Domain of unknown function (DUF309)
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
precursor_groups_12312 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_12648 195.65 +- 110.73 8 0 8 8 0.04 +- 0.14 8 5

TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term
PF05147 (8/8) Lanthionine synthetase C-like protein
PF04738 (8/8) Lantibiotic dehydratase, N terminus
PF00005 (7/8) ABC transporter
precursor_groups_64198 18.21 +- 8.46 2 0 0 0 0.15 +- 0.25 2 6

PF13406 (1/2) Transglycosylase SLT domain
PF03965 (1/2) Penicillinase repressor
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF01436 (1/2) NHL repeat
PF01435 (1/2) Peptidase family M48
PF00877 (1/2) NlpC/P60 family
precursor_groups_11440 97.75 +- 5.00 3 0 0 0 0.03 +- 0.02 3 7

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00916 (3/3) Sulfate permease family
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00484 (3/3) Carbonic anhydrase
PF00072 (3/3) Response regulator receiver domain
precursor_groups_71193 61.17 +- 3.83 2 0 0 0 0.03 +- 0.02 2 3

PF14031 (2/2) Putative serine dehydratase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01168 (2/2) Alanine racemase, N-terminal domain
precursor_groups_10641 2837.50 +- 2622.50 2 0 1 1 0.05 +- 0.09 2 26

TIGR04380 (1/2) inositol 2-dehydrogenase
TIGR04377 (1/2) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13520 (1/2) Amino acid permease
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF05378 (1/2) Hydantoinase/oxoprolinase N-terminal region
PF02954 (1/2) Bacterial regulatory protein, Fis family
PF02894 (1/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02538 (1/2) Hydantoinase B/oxoprolinase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01968 (1/2) Hydantoinase/oxoprolinase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01497 (1/2) Periplasmic binding protein
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01032 (1/2) FecCD transport family
PF00664 (1/2) ABC transporter transmembrane region
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00202 (1/2) Aminotransferase class-III
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
precursor_groups_6598 51.71 +- 28.64 5 0 5 0 0.17 +- 0.12 5 22

PF04116 (5/5) Fatty acid hydroxylase superfamily
TIGR01733 (4/5) amino acid adenylation domain
PF16884 (4/5) N-terminal domain of oxidoreductase
PF16197 (4/5) Ketoacyl-synthetase C-terminal extension
PF14765 (4/5) Polyketide synthase dehydratase
PF13450 (4/5) NAD(P)-binding Rossmann-like domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF08659 (4/5) KR domain
PF07690 (4/5) Major Facilitator Superfamily
PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain
PF01593 (4/5) Flavin containing amine oxidoreductase
PF00975 (4/5) Thioesterase domain
PF00698 (4/5) Acyl transferase domain
PF00668 (4/5) Condensation domain
PF00550 (4/5) Phosphopantetheine attachment site
PF00501 (4/5) AMP-binding enzyme
PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain
PF00107 (4/5) Zinc-binding dehydrogenase
PF17754 (3/5) MftR C-terminal domain
PF13561 (3/5) Enoyl-(Acyl carrier protein) reductase
PF00440 (3/5) Bacterial regulatory proteins, tetR family
PF00067 (3/5) Cytochrome P450
precursor_groups_7229 69.39 +- 8.93 7 0 0 0 0.15 +- 0.06 7 6

PF13416 (7/7) Bacterial extracellular solute-binding protein
PF13377 (7/7) Periplasmic binding protein-like domain
PF01204 (7/7) Trehalase
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00356 (7/7) Bacterial regulatory proteins, lacI family
PF13649 (6/7) Methyltransferase domain
precursor_groups_72342 13.34 +- 0.00 2 0 0 0 0.15 +- 0.18 2 3

PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF06224 (2/2) Winged helix DNA-binding domain
PF03176 (2/2) MMPL family
precursor_groups_29930 67.71 +- 0.00 2 0 0 0 0.07 +- 0.02 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00667 (2/2) FAD binding domain
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_groups_23100 121.56 +- 12.45 4 0 4 0 0.12 +- 0.17 4 9

TIGR01187 (4/4) polyamine ABC transporter, ATP-binding protein
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08402 (4/4) TOBE domain
PF01593 (4/4) Flavin containing amine oxidoreductase
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
precursor_groups_12861 703.23 +- 330.82 8 0 3 0 0.01 +- 0.01 8 9

PF18603 (8/8) L-amino acid ligase C-terminal domain 2
PF18130 (8/8) ATP-grasp N-terminal domain
PF13535 (8/8) ATP-grasp domain
PF01212 (8/8) Beta-eliminating lyase
PF00501 (8/8) AMP-binding enzyme
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF00288 (8/8) GHMP kinases N terminal domain
PF00206 (8/8) Lyase
PF00067 (8/8) Cytochrome P450
precursor_groups_23252 72.62 +- 26.87 4 0 0 0 0.10 +- 0.16 4 8

TIGR00350 (4/4) cell envelope-related function transcriptional attenuator common domain
PF13399 (4/4) LytR cell envelope-related transcriptional attenuator
PF07859 (4/4) alpha/beta hydrolase fold
PF03816 (4/4) Cell envelope-related transcriptional attenuator domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01258 (4/4) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00459 (4/4) Inositol monophosphatase family
precursor_groups_12262 28.49 +- 8.65 2 0 0 0 0.15 +- 0.16 2 5

PF14310 (2/2) Fibronectin type III-like domain
PF13802 (2/2) Galactose mutarotase-like
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
precursor_groups_46329 481.00 +- 41.72 3 0 0 0 0.02 +- 0.02 3 7

PF07940 (3/3) Heparinase II/III-like protein
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
precursor_groups_64889 24.60 +- 0.44 2 0 2 0 0.21 +- 0.12 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF11583 (1/2) P-aminobenzoate N-oxygenase AurF
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (1/2) 4Fe-4S binding domain
precursor_groups_11906 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_groups_75057 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_7423 2331.00 +- 9.00 2 0 2 0 0.01 +- 0.00 2 4

PF01757 (2/2) Acyltransferase family
PF00664 (2/2) ABC transporter transmembrane region
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_1819 163.15 +- 18.84 3 0 0 0 0.04 +- 0.03 3 5

PF13649 (3/3) Methyltransferase domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01047 (3/3) MarR family
PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
precursor_groups_60296 166.53 +- 14.34 2 0 2 0 0.07 +- 0.15 2 10

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF03861 (2/2) ANTAR domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00571 (2/2) CBS domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_8621 53.52 +- 0.01 2 0 2 0 0.15 +- 0.35 2 9

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02441 (2/2) Flavoprotein
PF01575 (2/2) MaoC like domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_15219 183.10 +- 147.40 3 0 3 0 0.11 +- 0.26 3 10

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF13586 (2/3) Transposase DDE domain
precursor_groups_16920 106.22 +- 42.36 2 0 2 2 0.05 +- 0.07 2 8

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05977 (2/2) Transmembrane secretion effector
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03466 (2/2) LysR substrate binding domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
precursor_groups_40017 14.16 +- 0.00 3 0 0 0 0.21 +- 0.07 3 5

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF03664 (3/3) Glycosyl hydrolase family 62
PF01341 (3/3) Glycosyl hydrolases family 6
PF00331 (3/3) Glycosyl hydrolase family 10
precursor_groups_40011 83.40 +- 59.07 3 0 0 0 0.21 +- 0.18 3 2

PF00296 (3/3) Luciferase-like monooxygenase
TIGR03860 (2/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
precursor_groups_34675 559.67 +- 425.21 3 0 3 3 0.01 +- 0.00 3 4

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
precursor_groups_48793 648.00 +- 132.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR01473 (2/2) protoheme IX farnesyltransferase
PF04261 (2/2) Dyp-type peroxidase family
PF01040 (2/2) UbiA prenyltransferase family
precursor_groups_22811 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF04978 (2/2) Protein of unknown function (DUF664)
precursor_groups_51393 486.72 +- 0.00 2 0 0 0 0.04 +- 0.02 2 10

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_22814 138.43 +- 42.71 4 0 0 0 0.13 +- 0.13 4 15

PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (4/4) Alpha galactosidase A
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF08450 (2/4) SMP-30/Gluconolactonase/LRE-like region
precursor_groups_72506 195.60 +- 94.65 2 0 2 0 0.02 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain
precursor_groups_22817 95.56 +- 0.00 2 0 0 0 0.04 +- 0.05 2 3

PF13560 (2/2) Helix-turn-helix domain
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_51399 1281.00 +- 525.00 2 0 0 0 0.02 +- 0.02 2 9

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF06889 (2/2) Protein of unknown function (DUF1266)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_3520 153.71 +- 111.16 4 0 2 0 0.03 +- 0.03 4 9

TIGR03889 (2/4) nitrile hydratase accessory protein
TIGR03888 (2/4) nitrile hydratase, beta subunit
TIGR01323 (2/4) nitrile hydratase, alpha subunit
PF07681 (2/4) DoxX
PF02979 (2/4) Nitrile hydratase, alpha chain
PF02900 (2/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF02515 (2/4) CoA-transferase family III
PF02211 (2/4) Nitrile hydratase beta subunit
PF00285 (2/4) Citrate synthase, C-terminal domain
precursor_groups_3521 285.24 +- 234.76 2 0 1 1 0.02 +- 0.02 2 9

PF16193 (1/2) AAA C-terminal domain
PF13471 (1/2) Transglutaminase-like superfamily
PF12002 (1/2) MgsA AAA+ ATPase C terminal
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04237 (1/2) YjbR
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_22215 74.55 +- 19.27 2 0 0 2 0.04 +- 0.05 2 7

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF03547 (2/2) Membrane transport protein
PF00892 (2/2) EamA-like transporter family
PF00881 (2/2) Nitroreductase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_64970 11.06 +- 0.00 2 0 2 0 0.18 +- 0.04 2 2

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_48005 178.81 +- 113.41 3 0 0 0 0.04 +- 0.05 3 2

PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_48004 74.74 +- 20.34 3 0 0 0 0.09 +- 0.11 3 5

PF08241 (3/3) Methyltransferase domain
PF05711 (3/3) Macrocin-O-methyltransferase (TylF)
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
precursor_groups_1211 920.66 +- 794.45 2 0 0 0 0.02 +- 0.10 2 20

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF10145 (1/2) Phage-related minor tail protein
PF05065 (1/2) Phage capsid family
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01580 (1/2) FtsK/SpoIIIE family
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01381 (1/2) Helix-turn-helix
PF01183 (1/2) Glycosyl hydrolases family 25
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_1742 44.92 +- 1.46 3 0 0 0 0.19 +- 0.30 3 8

TIGR03815 (3/3) helicase/secretion neighborhood CpaE-like protein
PF14029 (3/3) Protein of unknown function (DUF4244)
PF01656 (3/3) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
TIGR03819 (2/3) helicase/secretion neighborhood ATPase
TIGR03816 (2/3) helicase/secretion neighborhood TadE-like protein
PF07811 (2/3) TadE-like protein
PF00437 (2/3) Type II/IV secretion system protein
precursor_groups_1743 189.63 +- 70.37 2 0 1 0 0.05 +- 0.05 2 17

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
TIGR01426 (1/2) glycosyltransferase, MGT family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF14310 (1/2) Fibronectin type III-like domain
PF13489 (1/2) Methyltransferase domain
PF08659 (1/2) KR domain
PF03060 (1/2) Nitronate monooxygenase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00698 (1/2) Acyl transferase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_49577 696.60 +- 77.40 2 0 2 2 0.01 +- 0.00 2 9

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR00702 (2/2) YcaO-type kinase domain
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF08007 (2/2) Cupin superfamily protein
PF07812 (2/2) TfuA-like protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_11841 136.83 +- 87.53 3 0 2 0 0.02 +- 0.01 3 2

PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF04616 (3/3) Glycosyl hydrolases family 43
precursor_groups_69873 352.88 +- 167.12 2 0 2 2 0.02 +- 0.03 2 8

TIGR00702 (2/2) YcaO-type kinase domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF07812 (2/2) TfuA-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02543 (2/2) Carbamoyltransferase N-terminus
PF12802 (1/2) MarR family
precursor_groups_81580 206.40 +- 51.60 2 0 1 0 0.01 +- 0.01 2 3

PF01596 (2/2) O-methyltransferase
PF01474 (2/2) Class-II DAHP synthetase family
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
precursor_groups_11847 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 4

PF14478 (2/2) Domain of unknown function (DUF4430)
PF13377 (2/2) Periplasmic binding protein-like domain
PF01301 (2/2) Glycosyl hydrolases family 35
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_26318 38.62 +- 15.17 2 0 0 0 0.06 +- 0.10 2 5

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF14016 (2/2) Protein of unknown function (DUF4232)
PF12840 (2/2) Helix-turn-helix domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_69010 43.15 +- 12.56 2 0 0 0 0.05 +- 0.04 2 2

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_174 386.93 +- 278.10 7 0 7 7 0.05 +- 0.13 7 11

TIGR03897 (7/7) type 2 lantibiotic biosynthesis protein LanM
PF13575 (7/7) Domain of unknown function (DUF4135)
PF13191 (7/7) AAA ATPase domain
PF05147 (7/7) Lanthionine synthetase C-like protein
PF03704 (7/7) Bacterial transcriptional activator domain
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00196 (7/7) Bacterial regulatory proteins, luxR family
PF00931 (6/7) NB-ARC domain
PF13185 (4/7) GAF domain
PF08448 (4/7) PAS fold
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
precursor_groups_11633 50.00 +- 13.87 8 0 0 0 0.13 +- 0.09 8 5

PF07729 (8/8) FCD domain
PF03067 (8/8) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (8/8) Glycosyl hydrolase family 12
PF00553 (8/8) Cellulose binding domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
precursor_groups_30204 56.12 +- 11.39 4 0 0 0 0.04 +- 0.02 4 2

PF11706 (4/4) CGNR zinc finger
PF08962 (4/4) Domain of unknown function (DUF1876)
precursor_groups_62616 317.93 +- 51.48 2 0 0 0 0.05 +- 0.07 2 7

PF13649 (2/2) Methyltransferase domain
PF08242 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01411 (2/2) tRNA synthetases class II (A)
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_613 13.37 +- 1.08 2 0 0 0 0.15 +- 0.18 2 2

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03180 (2/2) NLPA lipoprotein
precursor_groups_48833 38.16 +- 4.73 2 0 0 0 0.21 +- 0.36 2 7

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03816 (2/2) helicase/secretion neighborhood TadE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_33088 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_10817 281.67 +- 81.07 3 0 0 0 0.01 +- 0.01 3 1

PF08007 (3/3) Cupin superfamily protein
precursor_groups_1104 76.23 +- 53.51 3 0 0 3 0.07 +- 0.11 3 2

PF00733 (3/3) Asparagine synthase
PF13649 (2/3) Methyltransferase domain
precursor_groups_9488 27.16 +- 9.53 3 0 0 0 0.08 +- 0.05 3 4

TIGR01810 (3/3) choline dehydrogenase
PF05199 (3/3) GMC oxidoreductase
PF02219 (3/3) Methylenetetrahydrofolate reductase
PF00732 (3/3) GMC oxidoreductase
precursor_groups_8174 30.50 +- 12.49 3 0 0 0 0.13 +- 0.16 3 5

PF17932 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14472 (3/3) Domain of unknown function (DUF4429)
PF09851 (3/3) Short C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_8175 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_groups_8170 82.65 +- 14.85 2 0 0 0 0.11 +- 0.03 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_8171 562.44 +- 521.84 6 0 0 0 0.05 +- 0.11 6 7

PF13407 (6/6) Periplasmic binding protein domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00294 (6/6) pfkB family carbohydrate kinase
PF00005 (6/6) ABC transporter
PF05025 (5/6) RbsD / FucU transport protein family
precursor_groups_20412 140.58 +- 52.50 3 0 0 0 0.13 +- 0.29 3 11

PF01061 (3/3) ABC-2 type transporter
PF00376 (3/3) MerR family regulatory protein
PF00005 (3/3) ABC transporter
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF13556 (2/3) PucR C-terminal helix-turn-helix domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF07690 (2/3) Major Facilitator Superfamily
PF03479 (2/3) Plants and Prokaryotes Conserved (PCC) domain
PF02803 (2/3) Thiolase, C-terminal domain
PF00501 (2/3) AMP-binding enzyme
PF00108 (2/3) Thiolase, N-terminal domain
precursor_groups_15549 113.38 +- 22.39 5 0 5 0 0.02 +- 0.01 5 4

PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_5114 288.80 +- 184.22 4 0 0 0 0.02 +- 0.01 4 6

PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF14498 (3/4) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (3/4) Ricin-type beta-trefoil lectin domain-like
PF07994 (3/4) Myo-inositol-1-phosphate synthase
PF03664 (3/4) Glycosyl hydrolase family 62
PF00150 (3/4) Cellulase (glycosyl hydrolase family 5)
precursor_groups_5111 106.66 +- 77.10 5 0 0 0 0.04 +- 0.04 5 3

PF00069 (5/5) Protein kinase domain
PF13302 (4/5) Acetyltransferase (GNAT) domain
PF07690 (4/5) Major Facilitator Superfamily
precursor_groups_5110 60.00 +- 12.55 3 0 0 0 0.19 +- 0.19 3 19

TIGR01186 (3/3) glycine betaine/L-proline transport ATP binding subunit
PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF01266 (3/3) FAD dependent oxidoreductase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
TIGR01374 (2/3) sarcosine oxidase, delta subunit family
TIGR01373 (2/3) sarcosine oxidase, beta subunit family
TIGR01372 (2/3) sarcosine oxidase, alpha subunit family
PF17806 (2/3) Sarcosine oxidase A3 domain
PF16350 (2/3) FAD dependent oxidoreductase central domain
PF13510 (2/3) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/3) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/3) Sarcosine oxidase, gamma subunit family
PF04267 (2/3) Sarcosine oxidase, delta subunit family
PF02882 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (2/3) Aminomethyltransferase folate-binding domain
PF00763 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_45202 1573.35 +- 1624.88 3 0 0 0 0.05 +- 0.17 3 13

TIGR01221 (3/3) dTDP-4-dehydrorhamnose 3,5-epimerase
TIGR01208 (3/3) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/3) dTDP-glucose 4,6-dehydratase
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF13649 (3/3) Methyltransferase domain
PF01636 (3/3) Phosphotransferase enzyme family
PF00908 (3/3) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00535 (3/3) Glycosyl transferase family 2
PF00483 (3/3) Nucleotidyl transferase
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00296 (3/3) Luciferase-like monooxygenase
PF00202 (3/3) Aminotransferase class-III
PF00005 (3/3) ABC transporter
precursor_groups_41765 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_groups_37630 258.00 +- 0.00 3 0 0 0 0.01 +- 0.00 3 3

PF12833 (3/3) Helix-turn-helix domain
PF02311 (3/3) AraC-like ligand binding domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_groups_26346 54.61 +- 22.32 3 0 0 0 0.06 +- 0.07 3 4

PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00583 (2/3) Acetyltransferase (GNAT) family
precursor_groups_8574 31.72 +- 11.32 6 0 0 0 0.11 +- 0.13 6 7

PF18011 (6/6) C-terminal domain found in long catalases
PF13520 (6/6) Amino acid permease
PF13439 (6/6) Glycosyltransferase Family 4
PF06628 (6/6) Catalase-related immune-responsive
PF02709 (6/6) N-terminal domain of galactosyltransferase
PF00534 (6/6) Glycosyl transferases group 1
PF00199 (6/6) Catalase
precursor_groups_50623 35.30 +- 20.41 2 0 2 0 0.09 +- 0.14 2 4

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (2/2) Phosphopantetheine attachment site
precursor_groups_9809 327.47 +- 96.83 3 0 3 0 0.02 +- 0.01 3 3

PF06912 (3/3) Protein of unknown function (DUF1275)
PF03928 (3/3) Haem-degrading
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_6745 24.66 +- 6.60 4 0 0 0 0.15 +- 0.17 4 12

PF14542 (4/4) GCN5-related N-acetyl-transferase
PF00857 (4/4) Isochorismatase family
PF14078 (3/4) Domain of unknown function (DUF4259)
PF13649 (3/4) Methyltransferase domain
PF06386 (3/4) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (3/4) Gas vesicle synthesis protein GvpO
PF05121 (3/4) Gas vesicle protein K
PF05120 (3/4) Gas vesicle protein G
PF03780 (3/4) Asp23 family, cell envelope-related function
PF03364 (3/4) Polyketide cyclase / dehydrase and lipid transport
PF00741 (3/4) Gas vesicle protein
PF06902 (2/4) Divergent 4Fe-4S mono-cluster
precursor_groups_2489 115.65 +- 92.27 4 0 0 4 0.24 +- 0.06 4 32

TIGR03026 (4/4) nucleotide sugar dehydrogenase
TIGR03025 (4/4) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF16889 (4/4) Heparinase II/III N-terminus
PF16254 (4/4) Domain of unknown function (DUF4910)
PF16221 (4/4) winged helix-turn-helix
PF13727 (4/4) CoA-binding domain
PF13692 (4/4) Glycosyl transferases group 1
PF13579 (4/4) Glycosyl transferase 4-like domain
PF13537 (4/4) Glutamine amidotransferase domain
PF13489 (4/4) Methyltransferase domain
PF13439 (4/4) Glycosyltransferase Family 4
PF13229 (4/4) Right handed beta helix region
PF08484 (4/4) C-methyltransferase C-terminal domain
PF08421 (4/4) Putative zinc binding domain
PF07940 (4/4) Heparinase II/III-like protein
PF04230 (4/4) Polysaccharide pyruvyl transferase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (4/4) Chain length determinant protein
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF02397 (4/4) Bacterial sugar transferase
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00908 (4/4) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (4/4) Asparagine synthase
PF00535 (4/4) Glycosyl transferase family 2
PF00534 (4/4) Glycosyl transferases group 1
PF00202 (4/4) Aminotransferase class-III
PF00107 (4/4) Zinc-binding dehydrogenase
TIGR01221 (2/4) dTDP-4-dehydrorhamnose 3,5-epimerase
precursor_groups_83455 23.24 +- 0.67 2 0 0 0 0.15 +- 0.30 2 7

TIGR00257 (2/2) uncharacterized protein, YigZ family
PF09186 (2/2) Domain of unknown function (DUF1949)
PF01205 (2/2) Uncharacterized protein family UPF0029
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_81483 6938.75 +- 1446.25 2 0 2 2 0.01 +- 0.00 2 8

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_groups_20892 218.99 +- 123.65 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF13649 (2/3) Methyltransferase domain
PF02899 (2/3) Phage integrase, N-terminal SAM-like domain
PF01636 (2/3) Phosphotransferase enzyme family
PF01135 (2/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/3) NUDIX domain
precursor_groups_8289 131.10 +- 38.06 7 0 4 0 0.14 +- 0.14 7 17

PF13407 (7/7) Periplasmic binding protein domain
PF13378 (7/7) Enolase C-terminal domain-like
PF07729 (7/7) FCD domain
PF05025 (7/7) RbsD / FucU transport protein family
PF02746 (7/7) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF00392 (7/7) Bacterial regulatory proteins, gntR family
PF00005 (7/7) ABC transporter
PF13561 (6/7) Enoyl-(Acyl carrier protein) reductase
PF08240 (6/7) Alcohol dehydrogenase GroES-like domain
PF00248 (6/7) Aldo/keto reductase family
PF00107 (6/7) Zinc-binding dehydrogenase
TIGR01182 (5/7) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF04909 (5/7) Amidohydrolase
PF01081 (5/7) KDPG and KHG aldolase
PF00294 (5/7) pfkB family carbohydrate kinase
PF08241 (4/7) Methyltransferase domain
precursor_groups_57717 194.25 +- 0.75 2 0 0 0 0.02 +- 0.01 2 2

PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_groups_4047 641.05 +- 586.71 3 0 0 0 0.05 +- 0.08 3 11

TIGR01141 (2/3) histidinol-phosphate transaminase
TIGR00797 (2/3) MATE efflux family protein
PF07690 (2/3) Major Facilitator Superfamily
PF02784 (2/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02423 (2/3) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/3) MatE
PF01497 (2/3) Periplasmic binding protein
PF01032 (2/3) FecCD transport family
PF00291 (2/3) Pyridoxal-phosphate dependent enzyme
PF00155 (2/3) Aminotransferase class I and II
PF00005 (2/3) ABC transporter
precursor_groups_4044 23.06 +- 12.40 3 0 1 0 0.14 +- 0.02 3 2

PF00120 (3/3) Glutamine synthetase, catalytic domain
PF00067 (3/3) Cytochrome P450
precursor_groups_28107 53.92 +- 18.08 2 0 0 0 0.11 +- 0.05 2 9

TIGR02133 (2/2) ribose 5-phosphate isomerase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00121 (2/2) Triosephosphate isomerase
precursor_groups_4514 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_groups_49755 17.03 +- 0.90 2 0 0 0 0.12 +- 0.15 2 5

TIGR01350 (2/2) dihydrolipoyl dehydrogenase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01638 (2/2) HxlR-like helix-turn-helix
precursor_groups_20090 465.60 +- 61.73 5 0 5 0 0.01 +- 0.00 5 5

PF05977 (5/5) Transmembrane secretion effector
PF05893 (5/5) Acyl-CoA reductase (LuxC)
PF04443 (5/5) Acyl-protein synthetase, LuxE
PF03756 (5/5) A-factor biosynthesis hotdog domain
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_groups_59866 629.50 +- 371.50 2 0 0 0 0.03 +- 0.01 2 11

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF13560 (1/2) Helix-turn-helix domain
PF09339 (1/2) IclR helix-turn-helix domain
PF02449 (1/2) Beta-galactosidase
PF01614 (1/2) Bacterial transcriptional regulator
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_4518 33.73 +- 10.19 3 0 0 0 0.10 +- 0.15 3 4

TIGR01701 (3/3) oxidoreductase alpha (molybdopterin) subunit
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_groups_52731 84.78 +- 0.00 2 0 2 0 0.06 +- 0.08 2 6

PF14759 (2/2) Reductase C-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09335 (2/2) SNARE associated Golgi protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450
precursor_groups_56051 150.50 +- 43.00 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_groups_41185 95.24 +- 15.97 2 0 0 0 0.05 +- 0.04 2 5

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF01457 (2/2) Leishmanolysin
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_31228 31.72 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_53 104.08 +- 48.18 2 0 0 0 0.19 +- 0.26 2 6

PF11774 (2/2) Lsr2
PF07730 (2/2) Histidine kinase
PF01061 (2/2) ABC-2 type transporter
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_62121 151.58 +- 28.42 2 0 0 0 0.02 +- 0.02 2 3

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_64423 194.00 +- 64.00 2 0 0 0 0.01 +- 0.00 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07859 (2/2) alpha/beta hydrolase fold
PF00743 (2/2) Flavin-binding monooxygenase-like
precursor_groups_1369 65.43 +- 29.36 30 0 0 25 0.13 +- 0.23 30 10

PF00291 (30/30) Pyridoxal-phosphate dependent enzyme
PF00132 (30/30) Bacterial transferase hexapeptide (six repeats)
PF02195 (29/30) ParB-like nuclease domain
TIGR00710 (27/30) drug resistance transporter, Bcr/CflA subfamily
PF12833 (27/30) Helix-turn-helix domain
PF07690 (27/30) Major Facilitator Superfamily
PF00067 (27/30) Cytochrome P450
TIGR01536 (25/30) asparagine synthase (glutamine-hydrolyzing)
PF13537 (25/30) Glutamine amidotransferase domain
PF00733 (25/30) Asparagine synthase
precursor_groups_5802 285.91 +- 19.20 3 0 0 0 0.03 +- 0.01 3 15

PF02353 (3/3) Mycolic acid cyclopropane synthetase
PF01266 (3/3) FAD dependent oxidoreductase
PF00550 (3/3) Phosphopantetheine attachment site
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12806 (2/3) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (2/3) Acyl-CoA dehydrogenase N terminal
PF07993 (2/3) Male sterility protein
PF07690 (2/3) Major Facilitator Superfamily
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF01814 (2/3) Hemerythrin HHE cation binding domain
PF00501 (2/3) AMP-binding enzyme
PF00487 (2/3) Fatty acid desaturase
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (2/3) Aminotransferase class I and II
PF00106 (2/3) short chain dehydrogenase
precursor_groups_8062 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_groups_31224 192.30 +- 126.21 4 0 0 0 0.22 +- 0.24 4 20

TIGR03860 (4/4) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01728 (4/4) ABC transporter, substrate-binding protein, aliphatic sulfonates family
TIGR01726 (4/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13410 (4/4) Glutathione S-transferase, C-terminal domain
PF09084 (4/4) NMT1/THI5 like
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00497 (4/4) Bacterial extracellular solute-binding proteins, family 3
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
PF08445 (3/4) FR47-like protein
TIGR03567 (2/4) FMN reductase
TIGR00738 (2/4) Rrf2 family protein
PF13187 (2/4) 4Fe-4S dicluster domain
PF08028 (2/4) Acyl-CoA dehydrogenase, C-terminal domain
PF03358 (2/4) NADPH-dependent FMN reductase
PF02910 (2/4) Fumarate reductase flavoprotein C-term
PF02771 (2/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/4) Transcriptional regulator
PF00890 (2/4) FAD binding domain
precursor_groups_49682 56.73 +- 9.21 2 0 0 0 0.09 +- 0.12 2 7

PF18029 (2/2) Glyoxalase-like domain
PF12867 (2/2) DinB superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_65956 141.35 +- 42.12 2 0 0 0 0.15 +- 0.22 2 11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
TIGR00738 (1/2) Rrf2 family protein
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (1/2) Transcriptional regulator
PF00486 (1/2) Transcriptional regulatory protein, C terminal
precursor_groups_4979 719.48 +- 312.52 2 0 2 0 0.02 +- 0.01 2 8

PF13452 (2/2) N-terminal half of MaoC dehydratase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF01575 (2/2) MaoC like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00890 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_63504 33.88 +- 2.23 2 0 0 0 0.15 +- 0.32 2 10

TIGR01935 (2/2) RraA family
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF04332 (2/2) Protein of unknown function (DUF475)
PF03737 (2/2) Aldolase/RraA
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
precursor_groups_1320 2290.40 +- 2315.72 11 0 5 11 0.04 +- 0.13 11 9

TIGR04267 (11/11) HEXXH motif domain
TIGR04085 (11/11) radical SAM additional 4Fe4S-binding SPASM domain
PF02223 (10/11) Thymidylate kinase
PF00293 (10/11) NUDIX domain
PF13714 (7/11) Phosphoenolpyruvate phosphomutase
PF13640 (7/11) 2OG-Fe(II) oxygenase superfamily
PF04055 (7/11) Radical SAM superfamily
PF02826 (7/11) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01909 (7/11) Nucleotidyltransferase domain
precursor_groups_36124 61.94 +- 1.47 2 0 0 2 0.06 +- 0.10 2 4

PF13649 (2/2) Methyltransferase domain
PF01183 (2/2) Glycosyl hydrolases family 25
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00881 (2/2) Nitroreductase family
precursor_groups_9713 976.01 +- 310.99 2 0 0 0 0.01 +- 0.02 2 7

PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (1/2) SAF domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF01476 (1/2) LysM domain
precursor_groups_46241 458.67 +- 0.00 3 0 0 0 0.01 +- 0.00 3 9

TIGR03025 (3/3) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (3/3) Glycosyl transferases group 1
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF13439 (3/3) Glycosyltransferase Family 4
PF04932 (3/3) O-Antigen ligase
PF03023 (3/3) Lipid II flippase MurJ
PF02397 (3/3) Bacterial sugar transferase
PF01522 (3/3) Polysaccharide deacetylase
PF00534 (3/3) Glycosyl transferases group 1
precursor_groups_72886 740.63 +- 220.63 2 0 0 0 0.02 +- 0.03 2 14

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07859 (2/2) alpha/beta hydrolase fold
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
TIGR00229 (1/2) PAS domain S-box protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF08448 (1/2) PAS fold
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04213 (1/2) Htaa
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
precursor_groups_729 410.04 +- 77.46 2 0 0 2 0.04 +- 0.05 2 7

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF06738 (2/2) Putative threonine/serine exporter
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_727 30.59 +- 4.59 2 0 0 0 0.07 +- 0.09 2 5

PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09594 (2/2) Glycosyltransferase family 87
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF10531 (1/2) SLBB domain
precursor_groups_70938 104.22 +- 29.22 2 0 2 2 0.06 +- 0.08 2 7

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF12840 (2/2) Helix-turn-helix domain
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_29794 87.31 +- 0.99 2 0 2 0 0.21 +- 0.36 2 15

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_19978 101.97 +- 50.53 3 0 0 0 0.13 +- 0.24 3 8

PF11758 (3/3) Aureocin-like type II bacteriocin
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
precursor_groups_24178 783.61 +- 267.79 4 0 0 0 0.02 +- 0.01 4 6

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
TIGR03919 (4/4) type VII secretion protein EccB
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
precursor_groups_80500 83.92 +- 28.63 2 0 1 0 0.10 +- 0.12 2 13

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13580 (2/2) SIS domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13242 (2/2) HAD-hyrolase-like
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
TIGR02199 (1/2) bifunctional protein RfaE, domain II
PF01467 (1/2) Cytidylyltransferase-like
PF00294 (1/2) pfkB family carbohydrate kinase
precursor_groups_38895 818.85 +- 360.44 3 0 3 0 0.03 +- 0.07 3 14

TIGR00229 (3/3) PAS domain S-box protein
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12832 (3/3) MFS_1 like family
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF01590 (3/3) GAF domain
PF01212 (3/3) Beta-eliminating lyase
PF00989 (3/3) PAS fold
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00156 (3/3) Phosphoribosyl transferase domain
PF00067 (3/3) Cytochrome P450
precursor_groups_5246 134.93 +- 74.60 8 0 0 0 0.20 +- 0.19 8 14

TIGR03860 (8/8) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF08445 (8/8) FR47-like protein
PF00296 (8/8) Luciferase-like monooxygenase
TIGR01726 (7/8) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (7/8) Binding-protein-dependent transport system inner membrane component
PF00497 (7/8) Bacterial extracellular solute-binding proteins, family 3
PF00005 (7/8) ABC transporter
PF01613 (6/8) Flavin reductase like domain
TIGR03558 (4/8) luciferase family oxidoreductase, group 1
PF13187 (4/8) 4Fe-4S dicluster domain
PF09084 (4/8) NMT1/THI5 like
PF02910 (4/8) Fumarate reductase flavoprotein C-term
PF02668 (4/8) Taurine catabolism dioxygenase TauD, TfdA family
PF00890 (4/8) FAD binding domain
precursor_groups_64514 107.50 +- 21.50 2 0 0 0 0.02 +- 0.01 2 3

TIGR03844 (2/2) cysteate synthase
PF00296 (2/2) Luciferase-like monooxygenase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_9025 19.00 +- 3.72 7 0 7 0 0.11 +- 0.07 7 4

PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (7/7) Conserved region in glutamate synthase
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
precursor_groups_46517 138.46 +- 43.67 3 0 0 0 0.03 +- 0.02 3 9

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_14436 152.88 +- 42.13 6 0 4 0 0.02 +- 0.01 6 4

PF14759 (6/6) Reductase C-terminal
PF14518 (6/6) Iron-containing redox enzyme
PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (6/6) Rieske [2Fe-2S] domain
precursor_groups_9029 1062.86 +- 363.39 10 0 0 0 0.03 +- 0.11 10 15

PF07859 (10/10) alpha/beta hydrolase fold
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF01408 (10/10) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (10/10) Xylose isomerase-like TIM barrel
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00440 (10/10) Bacterial regulatory proteins, tetR family
PF00155 (10/10) Aminotransferase class I and II
PF18565 (8/10) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (8/10) Domain of unknown function (DUF4982)
PF03737 (8/10) Aldolase/RraA
PF02837 (8/10) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (8/10) Glycosyl hydrolases family 2, TIM barrel domain
PF02775 (8/10) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01558 (8/10) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF00703 (8/10) Glycosyl hydrolases family 2
precursor_groups_584 16.98 +- 5.32 3 0 1 0 0.16 +- 0.22 3 1

PF13714 (3/3) Phosphoenolpyruvate phosphomutase
precursor_groups_46510 1186.67 +- 103.33 2 0 0 0 0.01 +- 0.00 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF14310 (2/2) Fibronectin type III-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_groups_81965 45.01 +- 6.31 2 0 2 0 0.14 +- 0.26 2 15

TIGR02416 (2/2) carbon-monoxide dehydrogenase, large subunit
TIGR00223 (2/2) aspartate 1-decarboxylase
PF14542 (2/2) GCN5-related N-acetyl-transferase
PF13478 (2/2) XdhC Rossmann domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF05762 (2/2) VWA domain containing CoxE-like protein
PF04945 (2/2) YHS domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF02261 (2/2) Aspartate decarboxylase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_14544 265.88 +- 185.62 2 0 0 2 0.03 +- 0.05 2 4

PF13649 (2/2) Methyltransferase domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
precursor_groups_39014 48.11 +- 10.37 3 0 0 0 0.15 +- 0.20 3 6

TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_groups_431 75.03 +- 68.85 59 0 0 0 0.17 +- 0.14 59 7

PF02449 (58/59) Beta-galactosidase
PF01670 (58/59) Glycosyl hydrolase family 12
PF00528 (58/59) Binding-protein-dependent transport system inner membrane component
PF08533 (57/59) Beta-galactosidase C-terminal domain
PF08532 (57/59) Beta-galactosidase trimerisation domain
PF13416 (56/59) Bacterial extracellular solute-binding protein
PF14498 (50/59) Glycosyl hydrolase family 65, N-terminal domain
precursor_groups_121 861.85 +- 1366.38 7 0 6 7 0.08 +- 0.16 7 13

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
PF03704 (7/7) Bacterial transcriptional activator domain
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00005 (7/7) ABC transporter
TIGR03604 (6/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/7) Lantibiotic biosynthesis dehydratase C-term
PF04738 (6/7) Lantibiotic dehydratase, N terminus
PF01061 (6/7) ABC-2 type transporter
PF00881 (6/7) Nitroreductase family
TIGR03892 (5/7) thiazolylpeptide-type bacteriocin precursor
TIGR01891 (4/7) amidohydrolase
PF01546 (4/7) Peptidase family M20/M25/M40
precursor_groups_36344 177.61 +- 4.56 2 0 0 0 0.12 +- 0.29 2 11

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03479 (2/2) Plants and Prokaryotes Conserved (PCC) domain
PF02803 (2/2) Thiolase, C-terminal domain
PF01061 (2/2) ABC-2 type transporter
PF00501 (2/2) AMP-binding enzyme
PF00376 (2/2) MerR family regulatory protein
PF00108 (2/2) Thiolase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_74837 407.43 +- 112.57 2 0 0 0 0.01 +- 0.00 2 4

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_43539 133.74 +- 6.33 3 0 0 0 0.13 +- 0.29 3 12

PF16925 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14534 (3/3) Domain of unknown function (DUF4440)
PF13602 (3/3) Zinc-binding dehydrogenase
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13160 (3/3) Protein of unknown function (DUF3995)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF05195 (3/3) Aminopeptidase P, N-terminal domain
PF04951 (3/3) D-aminopeptidase
PF00557 (3/3) Metallopeptidase family M24
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_4901 656.39 +- 462.45 5 0 5 0 0.07 +- 0.20 5 5

PF13649 (5/5) Methyltransferase domain
PF12697 (5/5) Alpha/beta hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
PF01593 (3/5) Flavin containing amine oxidoreductase
precursor_groups_2036 8.16 +- 0.03 2 0 0 0 0.25 +- 0.39 2 4

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF18029 (2/2) Glyoxalase-like domain
PF09335 (2/2) SNARE associated Golgi protein
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_groups_32689 61.54 +- 30.23 2 0 1 0 0.11 +- 0.20 2 14

TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13191 (2/2) AAA ATPase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00483 (2/2) Nucleotidyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_72269 42.83 +- 2.12 2 0 0 0 0.24 +- 0.36 2 13

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00072 (2/2) Response regulator receiver domain
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08241 (1/2) Methyltransferase domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF00691 (1/2) OmpA family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_13780 29.28 +- 15.54 4 0 0 0 0.11 +- 0.09 4 5

PF13361 (4/4) UvrD-like helicase C-terminal domain
PF13245 (4/4) AAA domain
PF04264 (4/4) YceI-like domain
PF00069 (4/4) Protein kinase domain
PF13546 (2/4) DDE superfamily endonuclease
precursor_groups_17037 70.82 +- 5.01 2 0 0 0 0.20 +- 0.15 2 11

PF13646 (2/2) HEAT repeats
PF13411 (2/2) MerR HTH family regulatory protein
PF12838 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF07702 (2/2) UTRA domain
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF01638 (2/2) HxlR-like helix-turn-helix
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
precursor_groups_81030 206.40 +- 51.60 2 0 0 0 0.02 +- 0.02 2 3

PF09594 (2/2) Glycosyltransferase family 87
PF06224 (2/2) Winged helix DNA-binding domain
PF00534 (2/2) Glycosyl transferases group 1
precursor_groups_21125 253.82 +- 91.01 5 0 5 0 0.02 +- 0.02 5 16

TIGR01733 (5/5) amino acid adenylation domain
TIGR01188 (5/5) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00838 (5/5) argininosuccinate lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF03767 (5/5) HAD superfamily, subfamily IIIB (Acid phosphatase)
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00288 (5/5) GHMP kinases N terminal domain
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_groups_622 173.17 +- 11.92 2 0 0 1 0.04 +- 0.14 2 20

TIGR01537 (1/2) phage portal protein, HK97 family
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13560 (1/2) Helix-turn-helix domain
PF13481 (1/2) AAA domain
PF13392 (1/2) HNH endonuclease
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF12840 (1/2) Helix-turn-helix domain
PF12728 (1/2) Helix-turn-helix domain
PF10145 (1/2) Phage-related minor tail protein
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF06199 (1/2) Phage tail tube protein
PF05135 (1/2) Phage gp6-like head-tail connector protein
PF04860 (1/2) Phage portal protein
PF04586 (1/2) Caudovirus prohead serine protease
PF04055 (1/2) Radical SAM superfamily
PF03237 (1/2) Terminase-like family
PF01844 (1/2) HNH endonuclease
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00436 (1/2) Single-strand binding protein family
precursor_groups_21123 528.78 +- 87.12 4 0 4 0 0.02 +- 0.03 4 6

PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_groups_33655 16.95 +- 6.10 3 0 0 0 0.16 +- 0.21 3 3

PF13309 (3/3) HTH domain
PF08348 (3/3) YheO-like PAS domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_50187 9.22 +- 0.48 2 0 2 0 0.22 +- 0.20 2 5

PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF13581 (1/2) Histidine kinase-like ATPase domain
precursor_groups_12159 219.24 +- 210.76 2 0 1 0 0.12 +- 0.17 2 12

PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF09084 (1/2) NMT1/THI5 like
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF06912 (1/2) Protein of unknown function (DUF1275)
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00075 (1/2) RNase H
PF00005 (1/2) ABC transporter
precursor_groups_2604 60.92 +- 21.76 12 0 0 0 0.21 +- 0.28 12 7

TIGR03860 (12/12) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (12/12) FAD-NAD(P)-binding
PF07920 (12/12) Protein of unknown function (DUF1684)
PF00296 (12/12) Luciferase-like monooxygenase
PF02983 (10/12) Alpha-lytic protease prodomain
PF01145 (10/12) SPFH domain / Band 7 family
PF00089 (10/12) Trypsin
precursor_groups_456 63.57 +- 36.92 20 0 0 0 0.21 +- 0.29 20 10

PF12911 (19/20) N-terminal TM domain of oligopeptide transport permease C
PF11997 (19/20) Domain of unknown function (DUF3492)
PF11350 (19/20) Protein of unknown function (DUF3152)
PF08352 (19/20) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (19/20) Binding-protein-dependent transport system inner membrane component
PF00496 (19/20) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (19/20) ABC transporter
PF13692 (18/20) Glycosyl transferases group 1
PF12138 (13/20) Spherulation-specific family 4
PF01370 (13/20) NAD dependent epimerase/dehydratase family
precursor_groups_75272 22.45 +- 0.32 2 0 0 0 0.18 +- 0.10 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04909 (2/2) Amidohydrolase
PF01575 (2/2) MaoC like domain
PF00501 (2/2) AMP-binding enzyme
PF00083 (2/2) Sugar (and other) transporter
TIGR01923 (1/2) O-succinylbenzoate-CoA ligase
precursor_groups_75275 60.86 +- 34.51 2 0 2 0 0.21 +- 0.27 2 11

PF13560 (2/2) Helix-turn-helix domain
PF05257 (2/2) CHAP domain
PF01987 (2/2) Mitochondrial biogenesis AIM24
PF01553 (2/2) Acyltransferase
PF01047 (2/2) MarR family
PF00400 (2/2) WD domain, G-beta repeat
TIGR00843 (1/2) benzoate transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12894 (1/2) Anaphase-promoting complex subunit 4 WD40 domain
PF03594 (1/2) Benzoate membrane transport protein
PF00106 (1/2) short chain dehydrogenase
precursor_groups_545 75.69 +- 94.92 70 0 70 70 0.08 +- 0.10 70 7

TIGR03882 (70/70) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (70/70) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (70/70) Histidine kinase
PF02624 (70/70) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (66/70) Bacterial regulatory proteins, luxR family
PF00072 (66/70) Response regulator receiver domain
PF12840 (62/70) Helix-turn-helix domain
precursor_groups_79699 57.78 +- 28.89 2 0 0 0 0.05 +- 0.03 2 2

PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_541 80.46 +- 42.01 3 0 0 0 0.20 +- 0.27 3 3

PF04616 (2/3) Glycosyl hydrolases family 43
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_542 209.47 +- 192.64 4 0 1 0 0.07 +- 0.08 4 1

PF00293 (2/4) NUDIX domain
precursor_groups_71213 274.12 +- 112.88 2 0 2 0 0.01 +- 0.01 2 5

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF00891 (2/2) O-methyltransferase domain
PF13577 (1/2) SnoaL-like domain
precursor_groups_53652 162.00 +- 33.00 2 0 0 0 0.02 +- 0.01 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_26828 91.26 +- 29.72 3 0 0 0 0.02 +- 0.02 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
precursor_groups_2598 114.23 +- 30.02 9 0 0 0 0.17 +- 0.09 9 4

PF13416 (9/9) Bacterial extracellular solute-binding protein
PF10091 (9/9) Putative glucoamylase
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00232 (9/9) Glycosyl hydrolase family 1
precursor_groups_86477 459.60 +- 159.60 2 0 2 0 0.02 +- 0.01 2 18

TIGR02814 (2/2) PfaD family protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF07977 (2/2) FabA-like domain
PF03060 (2/2) Nitronate monooxygenase
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR02813 (1/2) polyketide-type polyunsaturated fatty acid synthase PfaA
PF18328 (1/2) Fatty acid synthase subunit PfaD N-terminal domain
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00698 (1/2) Acyl transferase domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_76185 27.04 +- 2.28 2 0 0 0 0.15 +- 0.04 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF14667 (1/2) Polysaccharide biosynthesis C-terminal domain
precursor_groups_57037 163.67 +- 94.33 2 0 0 0 0.02 +- 0.01 2 4

PF12697 (2/2) Alpha/beta hydrolase family
PF10012 (2/2) Uncharacterized protein conserved in bacteria (DUF2255)
PF01738 (2/2) Dienelactone hydrolase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_24772 224.27 +- 49.13 3 0 3 0 0.01 +- 0.00 3 4

TIGR01490 (3/3) HAD hydrolase, family IB
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF03756 (3/3) A-factor biosynthesis hotdog domain
precursor_groups_16495 430.00 +- 215.00 2 0 2 0 0.02 +- 0.01 2 16

TIGR01426 (2/2) glycosyltransferase, MGT family
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13489 (2/2) Methyltransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08659 (2/2) KR domain
PF05345 (2/2) Putative Ig domain
PF04185 (2/2) Phosphoesterase family
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_12151 262.58 +- 109.46 7 0 0 0 0.01 +- 0.01 7 6

PF17137 (7/7) Domain of unknown function (DUF5110)
PF16990 (7/7) Carbohydrate binding module (family 35)
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF03595 (7/7) Voltage-dependent anion channel
PF02852 (7/7) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01055 (7/7) Glycosyl hydrolases family 31
precursor_groups_29257 419.05 +- 309.92 4 0 2 0 0.07 +- 0.06 4 11

TIGR01428 (4/4) haloacid dehalogenase, type II
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
TIGR01726 (2/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13416 (2/4) Bacterial extracellular solute-binding protein
PF08402 (2/4) TOBE domain
PF00497 (2/4) Bacterial extracellular solute-binding proteins, family 3
precursor_groups_17449 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_56289 49.54 +- 0.78 2 0 2 0 0.12 +- 0.29 2 9

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_67434 124.09 +- 5.91 2 0 0 0 0.02 +- 0.01 2 2

PF08808 (2/2) RES domain
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_2730 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08924 (2/2) Domain of unknown function (DUF1906)
PF06737 (2/2) Transglycosylase-like domain
precursor_groups_17443 91.70 +- 22.95 3 0 0 0 0.11 +- 0.18 3 4

PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF07690 (2/3) Major Facilitator Superfamily
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_43322 10.00 +- 1.15 3 0 0 0 0.20 +- 0.20 3 4

PF16113 (3/3) Enoyl-CoA hydratase/isomerase
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_43321 16.92 +- 1.44 2 0 0 0 0.18 +- 0.30 2 3

PF13649 (2/2) Methyltransferase domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_17445 130.88 +- 93.57 5 0 0 0 0.08 +- 0.16 5 6

TIGR01840 (5/5) esterase, PHB depolymerase family
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10605 (5/5) 3HB-oligomer hydrolase (3HBOH)
PF10503 (5/5) Esterase PHB depolymerase
PF07519 (5/5) Tannase and feruloyl esterase
PF00501 (5/5) AMP-binding enzyme
precursor_groups_85931 45.52 +- 7.25 2 0 0 0 0.07 +- 0.09 2 8

PF14759 (2/2) Reductase C-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08022 (2/2) FAD-binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04205 (2/2) FMN-binding domain
PF02424 (2/2) ApbE family
PF00083 (2/2) Sugar (and other) transporter
PF00067 (2/2) Cytochrome P450
precursor_groups_18669 2728.16 +- 778.76 5 0 5 0 0.01 +- 0.01 5 16

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
PF13649 (5/5) Methyltransferase domain
PF13560 (5/5) Helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07993 (5/5) Male sterility protein
PF00977 (5/5) Histidine biosynthesis protein
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00107 (5/5) Zinc-binding dehydrogenase
PF13304 (4/5) AAA domain, putative AbiEii toxin, Type IV TA system
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00005 (4/5) ABC transporter
precursor_groups_65486 81.84 +- 20.90 2 0 0 0 0.15 +- 0.15 2 16

PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00005 (2/2) ABC transporter
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07729 (1/2) FCD domain
PF01081 (1/2) KDPG and KHG aldolase
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00248 (1/2) Aldo/keto reductase family
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_53472 409.91 +- 174.38 2 0 0 0 0.04 +- 0.06 2 11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF12802 (2/2) MarR family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_groups_53476 454.06 +- 20.72 2 0 2 0 0.02 +- 0.02 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_14823 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_groups_35663 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
precursor_groups_4472 141.29 +- 30.71 2 0 0 0 0.04 +- 0.04 2 7

PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF05345 (1/2) Putative Ig domain
PF03060 (1/2) Nitronate monooxygenase
precursor_groups_2286 43.36 +- 36.39 3 0 0 0 0.14 +- 0.23 3 10

TIGR00589 (3/3) methylated-DNA--[protein]-cysteine S-methyltransferase
PF13532 (3/3) 2OG-Fe(II) oxygenase superfamily
PF12728 (3/3) Helix-turn-helix domain
PF12307 (3/3) Protein of unknown function (DUF3631)
PF09250 (3/3) Bifunctional DNA primase/polymerase, N-terminal
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF11750 (2/3) Protein of unknown function (DUF3307)
PF10935 (2/3) Protein of unknown function (DUF2637)
PF04461 (2/3) Protein of unknown function (DUF520)
PF00589 (2/3) Phage integrase family
precursor_groups_2283 143.26 +- 120.29 15 0 1 0 0.17 +- 0.22 15 25

PF13244 (13/15) Domain of unknown function (DUF4040)
PF09364 (13/15) XFP N-terminal domain
PF09363 (13/15) XFP C-terminal domain
PF04879 (13/15) Molybdopterin oxidoreductase Fe4S4 domain
PF04066 (13/15) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF03894 (13/15) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01568 (13/15) Molydopterin dinucleotide binding domain
PF00667 (13/15) FAD binding domain
PF00420 (13/15) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00384 (13/15) Molybdopterin oxidoreductase
PF00361 (13/15) Proton-conducting membrane transporter
PF00258 (13/15) Flavodoxin
PF00175 (13/15) Oxidoreductase NAD-binding domain
PF04039 (12/15) Domain related to MnhB subunit of Na+/H+ antiporter
PF14759 (11/15) Reductase C-terminal
PF07992 (11/15) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (11/15) Major Facilitator Superfamily
PF06276 (11/15) Ferric iron reductase FhuF-like transporter
PF04183 (11/15) IucA / IucC family
PF02784 (11/15) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (11/15) Periplasmic binding protein
PF00005 (11/15) ABC transporter
PF13535 (10/15) ATP-grasp domain
PF01032 (10/15) FecCD transport family
PF03328 (9/15) HpcH/HpaI aldolase/citrate lyase family
precursor_groups_38200 158.18 +- 110.97 3 0 3 0 0.09 +- 0.14 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (3/3) Sigma-70, region 4
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04542 (3/3) Sigma-70 region 2
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_groups_2281 800.06 +- 256.65 6 0 5 0 0.01 +- 0.01 6 11

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_groups_18660 56.94 +- 36.88 2 0 0 0 0.15 +- 0.28 2 8

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13459 (2/2) 4Fe-4S single cluster domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF07681 (1/2) DoxX
precursor_groups_12012 609.67 +- 386.30 6 0 6 6 0.05 +- 0.14 6 11

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (6/6) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (6/6) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (6/6) SagB-type dehydrogenase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (6/6) HlyD family secretion protein
PF03412 (6/6) Peptidase C39 family
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/6) Nitroreductase family
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
precursor_groups_27972 20.23 +- 0.90 3 0 0 3 0.20 +- 0.13 3 3

PF13360 (3/3) PQQ-like domain
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF00069 (3/3) Protein kinase domain
precursor_groups_70029 270.09 +- 57.37 2 0 0 2 0.07 +- 0.13 2 16

TIGR04283 (2/2) transferase 2, rSAM/selenodomain-associated
TIGR04282 (2/2) transferase 1, rSAM/selenodomain-associated
PF12850 (2/2) Calcineurin-like phosphoesterase superfamily domain
PF09837 (2/2) Uncharacterized protein conserved in bacteria (DUF2064)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07291 (2/2) Methylamine utilisation protein MauE
PF04055 (2/2) Radical SAM superfamily
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF02687 (2/2) FtsX-like permease family
PF01048 (2/2) Phosphorylase superfamily
PF00672 (2/2) HAMP domain
PF00535 (2/2) Glycosyl transferase family 2
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_70026 117.56 +- 27.56 2 0 1 0 0.03 +- 0.03 2 5

PF08124 (2/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07690 (2/2) Major Facilitator Superfamily
PF02884 (2/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (2/2) Polysaccharide lyase family 8, super-sandwich domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_66924 151.17 +- 22.17 2 0 0 0 0.03 +- 0.03 2 8

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07702 (2/2) UTRA domain
PF03747 (2/2) ADP-ribosylglycohydrolase
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF02133 (1/2) Permease for cytosine/purines, uracil, thiamine, allantoin
precursor_groups_70023 453.50 +- 66.50 2 0 2 2 0.01 +- 0.00 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF04303 (2/2) PrpF protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00881 (2/2) Nitroreductase family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00501 (1/2) AMP-binding enzyme
precursor_groups_75501 17.62 +- 4.04 2 0 0 0 0.12 +- 0.11 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
precursor_groups_74057 297.63 +- 115.17 2 0 2 0 0.05 +- 0.06 2 7

TIGR00157 (2/2) ribosome small subunit-dependent GTPase A
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13649 (2/2) Methyltransferase domain
PF03193 (2/2) RsgA GTPase
PF01061 (2/2) ABC-2 type transporter
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
precursor_groups_74055 33.84 +- 0.11 2 0 2 0 0.15 +- 0.21 2 9

PF13439 (2/2) Glycosyltransferase Family 4
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF01638 (2/2) HxlR-like helix-turn-helix
PF00534 (2/2) Glycosyl transferases group 1
precursor_groups_7174 172.05 +- 88.59 3 0 1 0 0.12 +- 0.24 3 2

PF13460 (2/3) NAD(P)H-binding
PF00248 (2/3) Aldo/keto reductase family
precursor_groups_35111 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_groups_18321 178.69 +- 94.17 6 0 0 0 0.02 +- 0.01 6 4

PF13377 (6/6) Periplasmic binding protein-like domain
PF01380 (6/6) SIS domain
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_groups_295 1918.66 +- 1562.71 78 0 62 51 0.03 +- 0.09 78 10

PF00465 (78/78) Iron-containing alcohol dehydrogenase
PF00202 (78/78) Aminotransferase class-III
PF00005 (78/78) ABC transporter
PF13649 (77/78) Methyltransferase domain
PF00296 (75/78) Luciferase-like monooxygenase
PF00069 (71/78) Protein kinase domain
PF05147 (47/78) Lanthionine synthetase C-like protein
PF00535 (45/78) Glycosyl transferase family 2
PF00483 (42/78) Nucleotidyl transferase
TIGR01208 (39/78) glucose-1-phosphate thymidylyltransferase
precursor_groups_14899 47.76 +- 34.35 7 0 7 0 0.05 +- 0.04 7 4

PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
PF00171 (7/7) Aldehyde dehydrogenase family
precursor_groups_7173 13.61 +- 4.20 4 0 4 0 0.19 +- 0.24 4 3

PF13424 (4/4) Tetratricopeptide repeat
PF08241 (4/4) Methyltransferase domain
PF00348 (4/4) Polyprenyl synthetase
precursor_groups_71620 206.87 +- 19.67 2 0 2 0 0.12 +- 0.25 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12840 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF09056 (2/2) Prokaryotic phospholipase A2
PF03704 (2/2) Bacterial transcriptional activator domain
PF03621 (2/2) MbtH-like protein
PF01804 (2/2) Penicillin amidase
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00067 (2/2) Cytochrome P450
precursor_groups_74227 296.25 +- 93.75 2 0 0 0 0.03 +- 0.07 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
TIGR03919 (1/2) type VII secretion protein EccB
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
precursor_groups_6297 121.17 +- 25.78 2 0 0 0 0.17 +- 0.31 2 14

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF10609 (2/2) NUBPL iron-transfer P-loop NTPase
PF07811 (2/2) TadE-like protein
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF18451 (1/2) Contact-dependent growth inhibition CdiA C-terminal domain
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF08666 (1/2) SAF domain
PF07730 (1/2) Histidine kinase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_groups_28899 190.95 +- 31.53 4 0 4 0 0.08 +- 0.03 4 17

TIGR03494 (4/4) salicylate synthase
TIGR01761 (4/4) thiazolinyl imide reductase
TIGR01733 (4/4) amino acid adenylation domain
PF18563 (4/4) TubC N-terminal docking domain
PF13649 (4/4) Methyltransferase domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08242 (4/4) Methyltransferase domain
PF03435 (4/4) Saccharopine dehydrogenase NADP binding domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00425 (4/4) chorismate binding enzyme
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_groups_24952 176.31 +- 11.52 2 0 2 0 0.11 +- 0.24 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF14016 (2/2) Protein of unknown function (DUF4232)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13460 (2/2) NAD(P)H-binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF04264 (2/2) YceI-like domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03321 (2/2) GH3 auxin-responsive promoter
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF01695 (2/2) IstB-like ATP binding protein
PF00665 (2/2) Integrase core domain
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF02910 (1/2) Fumarate reductase flavoprotein C-term
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_74459 247.04 +- 105.22 2 0 2 0 0.04 +- 0.05 2 14

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
TIGR01167 (1/2) LPXTG cell wall anchor domain
TIGR00842 (1/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF12680 (1/2) SnoaL-like domain
PF04203 (1/2) Sortase domain
PF02028 (1/2) BCCT, betaine/carnitine/choline family transporter
PF00561 (1/2) alpha/beta hydrolase fold
precursor_groups_24401 680.00 +- 57.77 4 0 4 4 0.01 +- 0.00 4 11

TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF13537 (4/4) Glutamine amidotransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05114 (4/4) Protein of unknown function (DUF692)
PF04303 (4/4) PrpF protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF01979 (4/4) Amidohydrolase family
PF00881 (4/4) Nitroreductase family
PF00733 (4/4) Asparagine synthase
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (3/4) Acyl-CoA dehydrogenase, middle domain
precursor_groups_78341 285.38 +- 234.62 2 0 0 0 0.04 +- 0.11 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_76561 33.95 +- 0.00 2 0 0 0 0.15 +- 0.32 2 9

TIGR00193 (2/2) urease, gamma subunit
TIGR00192 (2/2) urease, beta subunit
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF01979 (2/2) Amidohydrolase family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
precursor_groups_71775 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_75188 1161.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13279 (2/2) Thioesterase-like superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_40908 135.41 +- 41.08 3 0 2 0 0.02 +- 0.02 3 5

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00975 (3/3) Thioesterase domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
precursor_groups_2138 57.09 +- 28.29 9 0 0 0 0.04 +- 0.04 9 4

PF10974 (9/9) Protein of unknown function (DUF2804)
PF05922 (9/9) Peptidase inhibitor I9
PF01483 (9/9) Proprotein convertase P-domain
PF00082 (9/9) Subtilase family
precursor_groups_68048 1165.50 +- 4.50 2 0 0 0 0.01 +- 0.00 2 8

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF08402 (2/2) TOBE domain
PF04199 (2/2) Putative cyclase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_22339 239.34 +- 134.38 5 0 0 0 0.04 +- 0.05 5 5

TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (5/5) Major Facilitator Superfamily
PF01553 (5/5) Acyltransferase
PF01148 (5/5) Cytidylyltransferase family
PF01066 (5/5) CDP-alcohol phosphatidyltransferase
precursor_groups_30759 14.11 +- 0.89 2 0 0 0 0.14 +- 0.19 2 2

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_groups_6345 191.78 +- 19.93 3 0 0 0 0.13 +- 0.24 3 14

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00223 (3/3) aspartate 1-decarboxylase
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02261 (3/3) Aspartate decarboxylase
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
PF14498 (2/3) Glycosyl hydrolase family 65, N-terminal domain
precursor_groups_52458 285.17 +- 3.72 2 0 0 0 0.03 +- 0.03 2 5

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF01425 (2/2) Amidase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13546 (1/2) DDE superfamily endonuclease
PF01526 (1/2) Tn3 transposase DDE domain
precursor_groups_2130 58.68 +- 31.24 9 0 0 0 0.04 +- 0.04 9 2

PF03372 (9/9) Endonuclease/Exonuclease/phosphatase family
PF00583 (9/9) Acetyltransferase (GNAT) family
precursor_groups_6342 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_11212 795.64 +- 536.08 8 0 8 8 0.03 +- 0.08 8 12

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_groups_18747 106.59 +- 14.82 2 0 0 0 0.08 +- 0.07 2 8

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF13602 (2/2) Zinc-binding dehydrogenase
PF08281 (2/2) Sigma-70, region 4
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04542 (2/2) Sigma-70 region 2
PF01425 (2/2) Amidase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_groups_10694 166.19 +- 151.00 8 0 4 0 0.08 +- 0.14 8 13

TIGR01509 (8/8) HAD hydrolase, family IA, variant 3
PF13560 (8/8) Helix-turn-helix domain
PF12900 (8/8) Pyridoxamine 5'-phosphate oxidase
PF12724 (8/8) Flavodoxin domain
PF12679 (8/8) ABC-2 family transporter protein
PF08962 (8/8) Domain of unknown function (DUF1876)
PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF03636 (8/8) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (8/8) Glycosyl hydrolase family 65 central catalytic domain
PF00702 (8/8) haloacid dehalogenase-like hydrolase
PF00582 (8/8) Universal stress protein family
PF00107 (8/8) Zinc-binding dehydrogenase
PF00005 (8/8) ABC transporter
precursor_groups_52006 41.78 +- 18.92 2 0 0 0 0.12 +- 0.09 2 5

TIGR00504 (2/2) pyroglutamyl-peptidase I
PF11199 (2/2) Protein of unknown function (DUF2891)
PF06166 (2/2) Protein of unknown function (DUF979)
PF06149 (2/2) Protein of unknown function (DUF969)
PF01470 (2/2) Pyroglutamyl peptidase
precursor_groups_18743 145.12 +- 48.38 2 0 0 0 0.10 +- 0.20 2 11

TIGR02103 (2/2) alpha-1,6-glucosidases, pullulanase-type
PF17967 (2/2) Pullulanase N2 domain
PF11852 (2/2) Domain of unknown function (DUF3372)
PF03714 (2/2) Bacterial pullanase-associated domain
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (2/2) Alpha amylase, C-terminal all-beta domain
PF01356 (2/2) Alpha amylase inhibitor
PF00686 (2/2) Starch binding domain
PF00128 (2/2) Alpha amylase, catalytic domain
PF03176 (1/2) MMPL family
PF00589 (1/2) Phage integrase family
precursor_groups_30755 37.31 +- 5.54 3 0 0 0 0.11 +- 0.10 3 5

PF06723 (3/3) MreB/Mbl protein
PF03060 (3/3) Nitronate monooxygenase
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_34046 57.42 +- 1.60 2 0 0 0 0.17 +- 0.25 2 9

PF13671 (2/2) AAA domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_64367 2015.00 +- 65.00 2 0 0 0 0.01 +- 0.00 2 19

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16353 (2/2) Domain of unknown function(DUF4981)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF01370 (1/2) NAD dependent epimerase/dehydratase family
precursor_groups_27817 187.85 +- 203.21 4 0 0 0 0.12 +- 0.29 4 6

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF02142 (4/4) MGS-like domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00994 (4/4) Probable molybdopterin binding domain
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_63881 14.31 +- 0.32 2 0 0 0 0.21 +- 0.24 2 7

TIGR01581 (2/2) NifC-like ABC-type porter
PF08544 (2/2) GHMP kinases C terminal
PF03459 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_63882 171.32 +- 2.02 2 0 0 0 0.04 +- 0.02 2 11

TIGR00069 (2/2) histidinol dehydrogenase
PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00815 (2/2) Histidinol dehydrogenase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00106 (2/2) short chain dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_6901 39.49 +- 10.60 2 0 2 0 0.13 +- 0.10 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF07045 (2/2) Domain of unknown function (DUF1330)
PF03403 (2/2) Platelet-activating factor acetylhydrolase, isoform II
PF01047 (2/2) MarR family
PF01148 (1/2) Cytidylyltransferase family
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_3420 15.97 +- 3.83 3 0 0 0 0.13 +- 0.09 3 4

PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF01425 (3/3) Amidase
PF01411 (3/3) tRNA synthetases class II (A)
PF00474 (3/3) Sodium:solute symporter family
precursor_groups_3427 182.66 +- 123.23 2 0 2 0 0.10 +- 0.23 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_468 1476.17 +- 1286.68 5 0 4 3 0.04 +- 0.15 5 14

PF01063 (4/5) Amino-transferase class IV
TIGR01733 (3/5) amino acid adenylation domain
TIGR01536 (3/5) asparagine synthase (glutamine-hydrolyzing)
PF18130 (3/5) ATP-grasp N-terminal domain
PF13537 (3/5) Glutamine amidotransferase domain
PF13535 (3/5) ATP-grasp domain
PF13193 (3/5) AMP-binding enzyme C-terminal domain
PF07690 (3/5) Major Facilitator Superfamily
PF03547 (3/5) Membrane transport protein
PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00733 (3/5) Asparagine synthase
PF00550 (3/5) Phosphopantetheine attachment site
PF00501 (3/5) AMP-binding enzyme
PF00144 (3/5) Beta-lactamase
precursor_groups_77361 23.09 +- 9.24 2 0 0 0 0.20 +- 0.15 2 8

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF18029 (2/2) Glyoxalase-like domain
PF16116 (2/2) Domain of unknown function (DUF4832)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04476 (2/2) 4-HFC-P synthase
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_54440 268.29 +- 123.61 2 0 0 0 0.06 +- 0.16 2 14

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00975 (2/2) phosphate ABC transporter, phosphate-binding protein PstS
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00972 (2/2) phosphate ABC transporter, ATP-binding protein
PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF16640 (2/2) Bacterial Ig-like domain (group 3)
PF12849 (2/2) PBP superfamily domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05908 (2/2) Poly-gamma-glutamate hydrolase
PF04203 (2/2) Sortase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00041 (2/2) Fibronectin type III domain
PF00005 (2/2) ABC transporter
precursor_groups_49985 218.90 +- 2.24 2 0 0 0 0.01 +- 0.01 2 4

PF06094 (2/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF05995 (2/2) Cysteine dioxygenase type I
PF05977 (2/2) Transmembrane secretion effector
PF00581 (2/2) Rhodanese-like domain
precursor_groups_42459 325.00 +- 0.00 2 0 0 2 0.02 +- 0.01 2 8

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08242 (2/2) Methyltransferase domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00733 (2/2) Asparagine synthase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_18693 356.12 +- 90.16 4 0 4 0 0.14 +- 0.28 4 27

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01720 (4/4) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (4/4) Domain of unknown function (DUF4162)
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13279 (4/4) Thioesterase-like superfamily
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13160 (4/4) Protein of unknown function (DUF3995)
PF12146 (4/4) Serine aminopeptidase, S33
PF07977 (4/4) FabA-like domain
PF06368 (4/4) Methylaspartate mutase E chain (MutE)
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF02310 (4/4) B12 binding domain
PF01323 (4/4) DSBA-like thioredoxin domain
PF01061 (4/4) ABC-2 type transporter
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00005 (4/4) ABC transporter
precursor_groups_11260 44.04 +- 22.54 2 0 2 0 0.13 +- 0.18 2 6

PF17920 (2/2) Tetracyclin repressor-like, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF01764 (1/2) Lipase (class 3)
PF00248 (1/2) Aldo/keto reductase family
precursor_groups_25041 86.17 +- 42.83 2 0 0 0 0.03 +- 0.03 2 7

PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF07944 (1/2) Beta-L-arabinofuranosidase, GH127
precursor_groups_42980 212.05 +- 177.95 2 0 2 0 0.06 +- 0.14 2 9

TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (2/2) Glycosyl transferases group 1
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13439 (2/2) Glycosyltransferase Family 4
PF04932 (2/2) O-Antigen ligase
PF03023 (2/2) Lipid II flippase MurJ
PF02397 (2/2) Bacterial sugar transferase
PF01522 (2/2) Polysaccharide deacetylase
PF00534 (1/2) Glycosyl transferases group 1
precursor_groups_42981 80.99 +- 41.36 3 0 3 0 0.08 +- 0.18 3 9

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03567 (3/3) FMN reductase
TIGR01208 (3/3) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/3) dTDP-glucose 4,6-dehydratase
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF03358 (3/3) NADPH-dependent FMN reductase
PF01494 (3/3) FAD binding domain
PF00483 (3/3) Nucleotidyl transferase
PF00296 (3/3) Luciferase-like monooxygenase
precursor_groups_22794 927.20 +- 474.60 4 0 3 3 0.02 +- 0.03 4 13

PF05977 (4/4) Transmembrane secretion effector
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (4/4) ABC transporter
PF13581 (3/4) Histidine kinase-like ATPase domain
PF04672 (3/4) S-adenosyl methyltransferase
TIGR04364 (2/4) methyltransferase, FxLD system
TIGR04363 (2/4) FxLD family lantipeptide
TIGR03891 (2/4) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/4) Lanthionine synthetase C-like protein
PF04738 (2/4) Lantibiotic dehydratase, N terminus
PF00392 (2/4) Bacterial regulatory proteins, gntR family
PF00293 (2/4) NUDIX domain
precursor_groups_141 60.76 +- 26.51 6 0 0 0 0.18 +- 0.22 6 20

PF00144 (6/6) Beta-lactamase
TIGR01374 (4/6) sarcosine oxidase, delta subunit family
TIGR01373 (4/6) sarcosine oxidase, beta subunit family
TIGR01186 (4/6) glycine betaine/L-proline transport ATP binding subunit
PF17806 (4/6) Sarcosine oxidase A3 domain
PF16350 (4/6) FAD dependent oxidoreductase central domain
PF13510 (4/6) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (4/6) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (4/6) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (4/6) Sarcosine oxidase, gamma subunit family
PF04267 (4/6) Sarcosine oxidase, delta subunit family
PF04069 (4/6) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (4/6) Aminomethyltransferase folate-binding domain
PF01266 (4/6) FAD dependent oxidoreductase
PF00528 (4/6) Binding-protein-dependent transport system inner membrane component
PF00464 (4/6) Serine hydroxymethyltransferase
PF00171 (4/6) Aldehyde dehydrogenase family
PF00005 (4/6) ABC transporter
PF02882 (3/6) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (3/6) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_71324 20.36 +- 11.89 2 0 0 0 0.13 +- 0.15 2 6

PF12306 (1/2) Inclusion body protein
PF05336 (1/2) L-rhamnose mutarotase
PF04909 (1/2) Amidohydrolase
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01593 (1/2) Flavin containing amine oxidoreductase
precursor_groups_78012 710.45 +- 47.26 2 0 2 2 0.03 +- 0.03 2 20

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
precursor_groups_1957 58.48 +- 57.38 32 0 0 0 0.07 +- 0.07 32 3

PF12833 (32/32) Helix-turn-helix domain
PF02311 (32/32) AraC-like ligand binding domain
PF00150 (32/32) Cellulase (glycosyl hydrolase family 5)
precursor_groups_26033 156.11 +- 33.87 4 0 0 0 0.01 +- 0.02 4 1

PF00348 (4/4) Polyprenyl synthetase
precursor_groups_12653 199.97 +- 52.36 6 0 6 0 0.12 +- 0.17 6 19

TIGR01181 (6/6) dTDP-glucose 4,6-dehydratase
PF16363 (6/6) GDP-mannose 4,6 dehydratase
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF10604 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF07690 (6/6) Major Facilitator Superfamily
PF04672 (6/6) S-adenosyl methyltransferase
PF03559 (6/6) NDP-hexose 2,3-dehydratase
PF03358 (6/6) NADPH-dependent FMN reductase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF01757 (6/6) Acyltransferase family
PF01494 (6/6) FAD binding domain
PF01408 (6/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF01041 (6/6) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (6/6) Phosphopantetheine attachment site
PF00248 (6/6) Aldo/keto reductase family
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00106 (6/6) short chain dehydrogenase
PF04673 (5/6) Polyketide synthesis cyclase
precursor_groups_12655 93.70 +- 32.83 5 0 1 0 0.14 +- 0.12 5 6

PF01547 (5/5) Bacterial extracellular solute-binding protein
PF00942 (5/5) Cellulose binding domain
PF00728 (5/5) Glycosyl hydrolase family 20, catalytic domain
PF00722 (5/5) Glycosyl hydrolases family 16
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF02838 (4/5) Glycosyl hydrolase family 20, domain 2
precursor_groups_1951 389.61 +- 394.41 3 0 1 0 0.12 +- 0.20 3 9

TIGR01550 (3/3) death-on-curing family protein
PF02661 (3/3) Fic/DOC family
PF01402 (3/3) Ribbon-helix-helix protein, copG family
PF03450 (2/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/3) [2Fe-2S] binding domain
PF01315 (2/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_14948 539.92 +- 271.72 4 0 4 0 0.07 +- 0.18 4 17

TIGR01263 (3/4) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/4) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/4) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/4) Beta-lactamase superfamily domain
PF12697 (3/4) Alpha/beta hydrolase family
PF03621 (3/4) MbtH-like protein
PF02797 (3/4) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/4) ParB-like nuclease domain
PF01070 (3/4) FMN-dependent dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/4) ABC transporter transmembrane region
PF00583 (3/4) Acetyltransferase (GNAT) family
PF00378 (3/4) Enoyl-CoA hydratase/isomerase
PF00195 (3/4) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/4) Aminotransferase class I and II
PF00005 (3/4) ABC transporter
precursor_groups_10852 23.04 +- 0.00 2 0 0 0 0.13 +- 0.06 2 6

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02036 (2/2) SCP-2 sterol transfer family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_27792 36.17 +- 17.87 3 0 0 0 0.09 +- 0.12 3 3

PF06609 (3/3) Fungal trichothecene efflux pump (TRI12)
PF01656 (3/3) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01234 (3/3) NNMT/PNMT/TEMT family
precursor_groups_7509 2101.96 +- 1163.07 4 0 4 0 0.04 +- 0.10 4 29

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01444 (4/4) methyltransferase, FkbM family
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07977 (4/4) FabA-like domain
PF05977 (4/4) Transmembrane secretion effector
PF05050 (4/4) Methyltransferase FkbM domain
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02729 (4/4) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01323 (4/4) DSBA-like thioredoxin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00185 (4/4) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (4/4) Beta-lactamase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_14943 129.38 +- 72.75 5 0 0 5 0.05 +- 0.10 5 5

TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
PF13537 (5/5) Glutamine amidotransferase domain
PF00797 (5/5) N-acetyltransferase
PF00733 (5/5) Asparagine synthase
PF00135 (5/5) Carboxylesterase family
precursor_groups_76415 96.37 +- 5.37 2 0 0 0 0.03 +- 0.04 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_10659 104.00 +- 0.00 2 0 0 0 0.04 +- 0.02 2 3

PF08445 (2/2) FR47-like protein
PF04326 (2/2) Putative DNA-binding domain
PF03235 (2/2) Protein of unknown function DUF262
precursor_groups_84718 183.57 +- 34.20 2 0 2 0 0.11 +- 0.16 2 15

PF17677 (2/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (2/2) Alpha mannosidase middle domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (2/2) Trehalose utilisation
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF12802 (1/2) MarR family
PF05834 (1/2) Lycopene cyclase protein
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01209 (1/2) ubiE/COQ5 methyltransferase family
precursor_groups_44586 126.71 +- 45.68 3 0 0 0 0.06 +- 0.07 3 13

TIGR00778 (3/3) alkylhydroperoxidase AhpD family core domain
TIGR00566 (3/3) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (3/3) aminodeoxychorismate synthase, component I
PF12876 (3/3) Sugar-binding cellulase-like
PF08962 (3/3) Domain of unknown function (DUF1876)
PF07690 (3/3) Major Facilitator Superfamily
PF04715 (3/3) Anthranilate synthase component I, N terminal region
PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01063 (3/3) Amino-transferase class IV
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF00083 (3/3) Sugar (and other) transporter
precursor_groups_4130 112.98 +- 26.31 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF07883 (1/2) Cupin domain
PF01227 (1/2) GTP cyclohydrolase I
PF00561 (1/2) alpha/beta hydrolase fold
PF00293 (1/2) NUDIX domain
precursor_groups_11785 10.01 +- 0.86 8 0 8 0 0.20 +- 0.04 8 4

TIGR00055 (8/8) di-trans,poly-cis-decaprenylcistransferase
PF13202 (8/8) EF hand
PF09995 (8/8) Uncharacterized protein conserved in bacteria (DUF2236)
PF01255 (8/8) Putative undecaprenyl diphosphate synthase
precursor_groups_3089 38.24 +- 16.54 7 0 2 0 0.16 +- 0.25 7 3

PF04672 (7/7) S-adenosyl methyltransferase
PF13560 (6/7) Helix-turn-helix domain
PF04149 (6/7) Domain of unknown function (DUF397)
precursor_groups_82730 1424.50 +- 5.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR02946 (2/2) acyltransferase, WS/DGAT/MGAT
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06974 (2/2) Protein of unknown function (DUF1298)
PF03007 (2/2) Wax ester synthase-like Acyl-CoA acyltransferase domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_72662 192.55 +- 84.22 2 0 2 0 0.08 +- 0.17 2 13

PF16701 (2/2) Adenylate cyclase regulatory domain
PF00582 (2/2) Universal stress protein family
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13411 (1/2) MerR HTH family regulatory protein
PF13410 (1/2) Glutathione S-transferase, C-terminal domain
PF13409 (1/2) Glutathione S-transferase, N-terminal domain
PF12680 (1/2) SnoaL-like domain
PF06737 (1/2) Transglycosylase-like domain
PF06445 (1/2) GyrI-like small molecule binding domain
PF00664 (1/2) ABC transporter transmembrane region
PF00107 (1/2) Zinc-binding dehydrogenase
PF00069 (1/2) Protein kinase domain
precursor_groups_6631 16.35 +- 2.95 4 0 1 0 0.19 +- 0.05 4 6

PF02738 (4/4) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (4/4) [2Fe-2S] binding domain
PF01315 (4/4) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (4/4) FAD binding domain in molybdopterin dehydrogenase
PF00174 (3/4) Oxidoreductase molybdopterin binding domain
PF00111 (3/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_54669 34.95 +- 20.77 2 0 0 0 0.09 +- 0.10 2 2

PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
precursor_groups_2662 161.04 +- 139.96 2 0 0 0 0.11 +- 0.19 2 10

PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF13203 (1/2) Putative metallopeptidase domain
PF09967 (1/2) VWA-like domain (DUF2201)
PF07730 (1/2) Histidine kinase
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00072 (1/2) Response regulator receiver domain
precursor_groups_41235 63.35 +- 11.31 3 0 0 0 0.05 +- 0.03 3 4

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_68867 389.00 +- 131.00 2 0 0 0 0.03 +- 0.02 2 6

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_54666 810.16 +- 149.84 2 0 2 0 0.03 +- 0.02 2 17

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02441 (2/2) Flavoprotein
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_23267 361.87 +- 329.39 4 0 0 0 0.09 +- 0.12 4 7

PF14759 (4/4) Reductase C-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF01047 (4/4) MarR family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
precursor_groups_47204 286.05 +- 74.48 3 0 3 0 0.01 +- 0.00 3 5

PF13535 (3/3) ATP-grasp domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF05960 (3/3) Bacterial protein of unknown function (DUF885)
PF02195 (3/3) ParB-like nuclease domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_1821 389.07 +- 50.29 3 0 0 0 0.01 +- 0.01 3 18

PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
TIGR01558 (2/3) putative phage terminase, small subunit, P27 family
TIGR01554 (2/3) phage major capsid protein, HK97 family
TIGR01543 (2/3) phage prohead protease, HK97 family
TIGR01537 (2/3) phage portal protein, HK97 family
PF14594 (2/3) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/3) Phage-related minor tail protein
PF05119 (2/3) Phage terminase, small subunit
PF05065 (2/3) Phage capsid family
PF04860 (2/3) Phage portal protein
PF04851 (2/3) Type III restriction enzyme, res subunit
PF04586 (2/3) Caudovirus prohead serine protease
PF04542 (2/3) Sigma-70 region 2
PF03354 (2/3) Phage Terminase
PF01844 (2/3) HNH endonuclease
PF01391 (2/3) Collagen triple helix repeat (20 copies)
PF01381 (2/3) Helix-turn-helix
PF00271 (2/3) Helicase conserved C-terminal domain
precursor_groups_68266 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_69640 517.14 +- 77.14 2 0 0 0 0.01 +- 0.01 2 7

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (2/2) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_34191 79.47 +- 53.39 3 0 0 0 0.14 +- 0.17 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
TIGR03083 (2/3) uncharacterized Actinobacterial protein TIGR03083
PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF11716 (2/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07944 (2/3) Beta-L-arabinofuranosidase, GH127
PF07398 (2/3) MDMPI C-terminal domain
precursor_groups_26142 59.94 +- 18.43 3 0 0 0 0.04 +- 0.03 3 2

PF08241 (3/3) Methyltransferase domain
PF03403 (3/3) Platelet-activating factor acetylhydrolase, isoform II
precursor_groups_26143 135.60 +- 89.11 2 0 0 0 0.12 +- 0.27 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12833 (2/2) Helix-turn-helix domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_44077 547.42 +- 584.10 3 0 3 2 0.09 +- 0.23 3 24

TIGR03494 (3/3) salicylate synthase
TIGR02185 (3/3) putative ECF transporter S component, Trep_Strep family
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09605 (3/3) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF03704 (3/3) Bacterial transcriptional activator domain
PF02361 (3/3) Cobalt transport protein
PF00975 (3/3) Thioesterase domain
PF00931 (3/3) NB-ARC domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00425 (3/3) chorismate binding enzyme
PF00005 (3/3) ABC transporter
TIGR03696 (2/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
TIGR01443 (2/3) intein C-terminal splicing region
PF13537 (2/3) Glutamine amidotransferase domain
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat
PF00733 (2/3) Asparagine synthase
PF00664 (2/3) ABC transporter transmembrane region
precursor_groups_68464 31.41 +- 2.73 2 0 0 0 0.22 +- 0.34 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13620 (2/2) Carboxypeptidase regulatory-like domain
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF04264 (2/2) YceI-like domain
PF01047 (2/2) MarR family
precursor_groups_18107 45.54 +- 25.47 3 0 0 0 0.11 +- 0.14 3 5

TIGR03666 (3/3) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07690 (3/3) Major Facilitator Superfamily
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_15205 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
precursor_groups_70749 354.22 +- 42.22 2 0 0 0 0.05 +- 0.07 2 22

TIGR01552 (2/2) prevent-host-death family protein
TIGR00663 (2/2) DNA polymerase III, beta subunit
TIGR00348 (2/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/2) SWI2/SNF2 ATPase
PF13476 (2/2) AAA domain
PF13304 (2/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (2/2) HsdM N-terminal domain
PF11867 (2/2) Domain of unknown function (DUF3387)
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF05016 (2/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF04073 (2/2) Aminoacyl-tRNA editing domain
PF02768 (2/2) DNA polymerase III beta subunit, C-terminal domain
PF02767 (2/2) DNA polymerase III beta subunit, central domain
PF02604 (2/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02384 (2/2) N-6 DNA Methylase
PF02274 (2/2) Amidinotransferase
PF01565 (2/2) FAD binding domain
PF01420 (2/2) Type I restriction modification DNA specificity domain
PF00712 (2/2) DNA polymerase III beta subunit, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_54263 209.21 +- 56.32 2 0 2 0 0.06 +- 0.12 2 12

PF13407 (2/2) Periplasmic binding protein domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01263 (2/2) Aldose 1-epimerase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00005 (2/2) ABC transporter
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
precursor_groups_22806 533.02 +- 637.84 5 0 0 0 0.01 +- 0.00 5 3

TIGR03930 (5/5) WXG100 family type VII secretion target
PF06013 (5/5) Proteins of 100 residues with WXG
PF00082 (5/5) Subtilase family
precursor_groups_7655 403.67 +- 214.34 10 0 0 0 0.04 +- 0.05 10 7

PF13531 (10/10) Bacterial extracellular solute-binding protein
PF08402 (10/10) TOBE domain
PF00694 (10/10) Aconitase C-terminal domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00005 (10/10) ABC transporter
PF08445 (5/10) FR47-like protein
PF00106 (5/10) short chain dehydrogenase
precursor_groups_7650 114.78 +- 35.75 6 0 0 5 0.23 +- 0.08 6 34

TIGR03026 (6/6) nucleotide sugar dehydrogenase
PF13857 (6/6) Ankyrin repeats (many copies)
PF13692 (6/6) Glycosyl transferases group 1
PF13579 (6/6) Glycosyl transferase 4-like domain
PF06628 (6/6) Catalase-related immune-responsive
PF03721 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (6/6) Chain length determinant protein
PF00984 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00199 (6/6) Catalase
TIGR01536 (5/6) asparagine synthase (glutamine-hydrolyzing)
PF16889 (5/6) Heparinase II/III N-terminus
PF16254 (5/6) Domain of unknown function (DUF4910)
PF16221 (5/6) winged helix-turn-helix
PF13537 (5/6) Glutamine amidotransferase domain
PF13489 (5/6) Methyltransferase domain
PF13439 (5/6) Glycosyltransferase Family 4
PF08484 (5/6) C-methyltransferase C-terminal domain
PF08421 (5/6) Putative zinc binding domain
PF07940 (5/6) Heparinase II/III-like protein
PF04230 (5/6) Polysaccharide pyruvyl transferase
PF02585 (5/6) GlcNAc-PI de-N-acetylase
PF01408 (5/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (5/6) NAD dependent epimerase/dehydratase family
PF00908 (5/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (5/6) Asparagine synthase
PF00535 (5/6) Glycosyl transferase family 2
PF00534 (5/6) Glycosyl transferases group 1
PF00202 (5/6) Aminotransferase class-III
PF00107 (5/6) Zinc-binding dehydrogenase
PF13229 (4/6) Right handed beta helix region
TIGR03025 (3/6) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (3/6) CoA-binding domain
PF02397 (3/6) Bacterial sugar transferase
precursor_groups_7635 99.68 +- 36.29 6 0 0 0 0.13 +- 0.13 6 10

TIGR01382 (6/6) intracellular protease, PfpI family
PF09123 (6/6) Domain of unknown function (DUF1931)
PF01965 (6/6) DJ-1/PfpI family
PF13823 (5/6) Alcohol dehydrogenase GroES-associated
PF08240 (5/6) Alcohol dehydrogenase GroES-like domain
PF07690 (5/6) Major Facilitator Superfamily
PF00248 (5/6) Aldo/keto reductase family
PF00107 (5/6) Zinc-binding dehydrogenase
PF13515 (4/6) Fusaric acid resistance protein-like
PF12805 (4/6) FUSC-like inner membrane protein yccS
precursor_groups_20660 144.72 +- 11.28 2 0 2 2 0.04 +- 0.04 2 3

PF13471 (2/2) Transglutaminase-like superfamily
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase
precursor_groups_1775 140.34 +- 66.06 2 0 1 0 0.11 +- 0.23 2 14

TIGR02100 (1/2) glycogen debranching enzyme GlgX
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13546 (1/2) DDE superfamily endonuclease
PF11991 (1/2) Tryptophan dimethylallyltransferase
PF07221 (1/2) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF05331 (1/2) Protein of unknown function (DUF742)
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02922 (1/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01301 (1/2) Glycosyl hydrolases family 35
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00480 (1/2) ROK family
PF00128 (1/2) Alpha amylase, catalytic domain
precursor_groups_45988 29.33 +- 4.05 3 0 0 0 0.10 +- 0.11 3 5

PF13517 (3/3) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF12867 (3/3) DinB superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF00089 (3/3) Trypsin
precursor_groups_45981 711.18 +- 425.39 2 0 2 0 0.04 +- 0.09 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12261 (2/2) Thermostable hemolysin
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07977 (2/2) FabA-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF01593 (1/2) Flavin containing amine oxidoreductase
precursor_groups_11875 240.06 +- 154.43 2 0 0 0 0.07 +- 0.12 2 6

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_44105 282.57 +- 61.43 2 0 0 0 0.02 +- 0.02 2 4

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01713 (2/2) Smr domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_11303 200.11 +- 58.80 3 0 0 0 0.04 +- 0.03 3 12

TIGR01167 (3/3) LPXTG cell wall anchor domain
PF18130 (3/3) ATP-grasp N-terminal domain
PF17802 (3/3) Prealbumin-like fold domain
PF16259 (3/3) Domain of unknown function (DUF4913)
PF13535 (3/3) ATP-grasp domain
PF12307 (3/3) Protein of unknown function (DUF3631)
PF08239 (3/3) Bacterial SH3 domain
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF02899 (3/3) Phage integrase, N-terminal SAM-like domain
PF01638 (3/3) HxlR-like helix-turn-helix
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_groups_10786 86.49 +- 106.63 9 0 0 0 0.14 +- 0.30 9 4

PF07504 (9/9) Fungalysin/Thermolysin Propeptide Motif
PF03713 (9/9) Domain of unknown function (DUF305)
PF02868 (9/9) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (9/9) Thermolysin metallopeptidase, catalytic domain
precursor_groups_27141 15.76 +- 0.00 2 0 0 0 0.13 +- 0.00 2 2

PF13649 (2/2) Methyltransferase domain
PF07859 (2/2) alpha/beta hydrolase fold
precursor_groups_32864 218.12 +- 168.88 2 0 0 0 0.15 +- 0.33 2 12

PF08007 (2/2) Cupin superfamily protein
PF06999 (2/2) Sucrase/ferredoxin-like
TIGR00459 (1/2) aspartate--tRNA ligase
PF16193 (1/2) AAA C-terminal domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF12002 (1/2) MgsA AAA+ ATPase C terminal
PF04087 (1/2) Domain of unknown function (DUF389)
PF03243 (1/2) Alkylmercury lyase
PF01336 (1/2) OB-fold nucleic acid binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00152 (1/2) tRNA synthetases class II (D, K and N)
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_66705 1241.09 +- 448.91 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_32866 197.39 +- 31.14 3 0 0 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_groups_77202 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 6

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF11706 (2/2) CGNR zinc finger
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
precursor_groups_37537 176.81 +- 151.17 3 0 0 0 0.08 +- 0.12 3 10

PF13546 (3/3) DDE superfamily endonuclease
PF03358 (3/3) NADPH-dependent FMN reductase
PF01474 (3/3) Class-II DAHP synthetase family
PF00106 (3/3) short chain dehydrogenase
TIGR04316 (2/3) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF01494 (2/3) FAD binding domain
PF00857 (2/3) Isochorismatase family
PF00501 (2/3) AMP-binding enzyme
PF00425 (2/3) chorismate binding enzyme
PF00117 (2/3) Glutamine amidotransferase class-I
precursor_groups_29786 136.72 +- 7.72 2 0 0 0 0.01 +- 0.01 2 3

PF09362 (2/2) Domain of unknown function (DUF1996)
PF08924 (2/2) Domain of unknown function (DUF1906)
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_31125 277.50 +- 293.57 4 0 0 0 0.02 +- 0.04 4 9

TIGR01167 (4/4) LPXTG cell wall anchor domain
PF17802 (4/4) Prealbumin-like fold domain
PF13535 (4/4) ATP-grasp domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01555 (4/4) DNA methylase
PF00746 (4/4) LPXTG cell wall anchor motif
PF16259 (3/4) Domain of unknown function (DUF4913)
PF01638 (3/4) HxlR-like helix-turn-helix
precursor_groups_20799 13.49 +- 0.49 2 0 0 0 0.15 +- 0.12 2 7

PF13439 (2/2) Glycosyltransferase Family 4
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
PF00534 (2/2) Glycosyl transferases group 1
PF11720 (1/2) Peptidase inhibitor I78 family
precursor_groups_602 70.45 +- 23.35 12 0 0 0 0.20 +- 0.34 12 7

TIGR03819 (12/12) helicase/secretion neighborhood ATPase
TIGR03815 (12/12) helicase/secretion neighborhood CpaE-like protein
PF14029 (12/12) Protein of unknown function (DUF4244)
PF00482 (12/12) Type II secretion system (T2SS), protein F
PF00437 (12/12) Type II/IV secretion system protein
PF01656 (9/12) CobQ/CobB/MinD/ParA nucleotide binding domain
TIGR03816 (7/12) helicase/secretion neighborhood TadE-like protein
precursor_groups_601 491.93 +- 411.15 16 0 5 1 0.04 +- 0.10 16 1

PF07690 (8/16) Major Facilitator Superfamily
precursor_groups_600 21.00 +- 9.59 26 0 3 0 0.18 +- 0.27 26 12

PF06386 (26/26) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (26/26) Gas vesicle synthesis protein GvpO
PF05121 (26/26) Gas vesicle protein K
PF05120 (26/26) Gas vesicle protein G
PF03364 (26/26) Polyketide cyclase / dehydrase and lipid transport
PF00741 (26/26) Gas vesicle protein
PF17657 (23/26) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (23/26) Helix-hairpin-helix motif
PF07733 (23/26) Bacterial DNA polymerase III alpha NTPase domain
PF02811 (23/26) PHP domain
TIGR00594 (22/26) DNA polymerase III, alpha subunit
PF00817 (22/26) impB/mucB/samB family
precursor_groups_606 53.04 +- 18.40 3 0 0 0 0.10 +- 0.11 3

No common domains found
precursor_groups_605 272.47 +- 200.70 6 0 1 1 0.08 +- 0.12 6 3

PF01145 (6/6) SPFH domain / Band 7 family
PF00528 (5/6) Binding-protein-dependent transport system inner membrane component
PF00005 (5/6) ABC transporter
precursor_groups_12656 109.96 +- 51.74 4 0 2 0 0.06 +- 0.06 4 4

PF13673 (4/4) Acetyltransferase (GNAT) domain
PF13411 (3/4) MerR HTH family regulatory protein
PF08534 (3/4) Redoxin
PF00701 (3/4) Dihydrodipicolinate synthetase family
precursor_groups_11898 126.39 +- 94.33 5 0 0 0 0.16 +- 0.30 5 10

PF05331 (5/5) Protein of unknown function (DUF742)
PF04472 (5/5) Cell division protein SepF
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF13416 (4/5) Bacterial extracellular solute-binding protein
PF12643 (4/5) MazG-like family
precursor_groups_28782 186.18 +- 122.33 3 0 0 0 0.11 +- 0.15 3 11

PF12802 (3/3) MarR family
PF07883 (3/3) Cupin domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/3) IclR helix-turn-helix domain
PF07690 (2/3) Major Facilitator Superfamily
PF04909 (2/3) Amidohydrolase
PF04199 (2/3) Putative cyclase
PF01614 (2/3) Bacterial transcriptional regulator
PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_30984 5344.50 +- 176.64 4 0 4 4 0.01 +- 0.00 4 15

TIGR04267 (4/4) HEXXH motif domain
TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF14907 (4/4) Uncharacterised nucleotidyltransferase
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF13640 (4/4) 2OG-Fe(II) oxygenase superfamily
PF08241 (4/4) Methyltransferase domain
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF02223 (4/4) Thymidylate kinase
PF02195 (4/4) ParB-like nuclease domain
PF01909 (4/4) Nucleotidyltransferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00293 (4/4) NUDIX domain
PF00202 (4/4) Aminotransferase class-III
precursor_groups_1173 675.68 +- 902.40 57 0 57 57 0.04 +- 0.03 57 9

TIGR03891 (56/57) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (56/57) Lantibiotic biosynthesis dehydratase C-term
PF05147 (56/57) Lanthionine synthetase C-like protein
PF04738 (56/57) Lantibiotic dehydratase, N terminus
PF00196 (56/57) Bacterial regulatory proteins, luxR family
PF00005 (56/57) ABC transporter
PF05139 (55/57) Erythromycin esterase
PF00296 (55/57) Luciferase-like monooxygenase
PF00392 (42/57) Bacterial regulatory proteins, gntR family
precursor_groups_17202 186.69 +- 106.02 5 0 0 5 0.05 +- 0.05 5 7

TIGR00778 (5/5) alkylhydroperoxidase AhpD family core domain
PF13714 (5/5) Phosphoenolpyruvate phosphomutase
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF04237 (5/5) YjbR
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00881 (5/5) Nitroreductase family
PF00107 (5/5) Zinc-binding dehydrogenase
precursor_groups_44850 14.59 +- 2.01 2 0 0 0 0.14 +- 0.07 2 5

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF14378 (1/2) PAP2 superfamily
precursor_groups_28787 282.32 +- 186.77 2 0 0 2 0.03 +- 0.04 2 5

TIGR03930 (2/2) WXG100 family type VII secretion target
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
precursor_groups_7054 764.64 +- 456.88 4 0 4 0 0.04 +- 0.12 4 5

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01593 (3/4) Flavin containing amine oxidoreductase
precursor_groups_8149 20.57 +- 6.31 7 0 7 0 0.18 +- 0.23 7 6

PF13354 (7/7) Beta-lactamase enzyme family
PF03466 (7/7) LysR substrate binding domain
PF01380 (7/7) SIS domain
PF01116 (7/7) Fructose-bisphosphate aldolase class-II
PF00126 (7/7) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR00167 (6/7) ketose-bisphosphate aldolase
precursor_groups_5104 109.39 +- 45.43 3 0 0 0 0.15 +- 0.21 3 1

PF07690 (3/3) Major Facilitator Superfamily
precursor_groups_29656 335.69 +- 220.01 2 0 1 1 0.08 +- 0.18 2 23

PF17195 (2/2) Protein of unknown function (DUF5132)
PF00664 (2/2) ABC transporter transmembrane region
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
TIGR01733 (1/2) amino acid adenylation domain
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12833 (1/2) Helix-turn-helix domain
PF11814 (1/2) Peptidase_C39 like family
PF08242 (1/2) Methyltransferase domain
PF03621 (1/2) MbtH-like protein
PF02311 (1/2) AraC-like ligand binding domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00975 (1/2) Thioesterase domain
PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region
PF00733 (1/2) Asparagine synthase
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00326 (1/2) Prolyl oligopeptidase family
precursor_groups_23680 549.28 +- 205.94 3 0 0 0 0.01 +- 0.01 3 13

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03925 (3/3) type VII secretion protein EccCb
TIGR03924 (3/3) type VII secretion protein EccCa
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF17866 (3/3) AAA lid domain
PF13229 (3/3) Right handed beta helix region
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
PF01580 (3/3) FtsK/SpoIIIE family
PF00004 (3/3) ATPase family associated with various cellular activities (AAA)
precursor_groups_37629 339.61 +- 180.52 3 0 0 0 0.07 +- 0.11 3 7

TIGR03296 (3/3) M6 family metalloprotease domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/3) ABC transporter
precursor_groups_5012 53.53 +- 1.90 5 0 0 0 0.21 +- 0.33 5 15

TIGR02115 (5/5) K+-transporting ATPase, F subunit
TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR01497 (5/5) K+-transporting ATPase, B subunit
TIGR00681 (5/5) K+-transporting ATPase, C subunit
TIGR00680 (5/5) K+-transporting ATPase, A subunit
TIGR00374 (5/5) TIGR00374 family protein
PF09604 (5/5) F subunit of K+-transporting ATPase (Potass_KdpF)
PF03814 (5/5) Potassium-transporting ATPase A subunit
PF03706 (5/5) Lysylphosphatidylglycerol synthase TM region
PF02702 (5/5) Osmosensitive K+ channel His kinase sensor domain
PF02669 (5/5) K+-transporting ATPase, c chain
PF01814 (5/5) Hemerythrin HHE cation binding domain
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00582 (5/5) Universal stress protein family
PF00122 (5/5) E1-E2 ATPase
precursor_groups_27569 712.24 +- 556.22 4 0 4 0 0.06 +- 0.18 4 11

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10604 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_51232 13.71 +- 0.11 2 0 0 0 0.22 +- 0.17 2 7

TIGR03723 (2/2) tRNA threonylcarbamoyl adenosine modification protein TsaD
TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
PF00814 (2/2) Glycoprotease family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_19229 64.75 +- 9.02 4 0 0 0 0.11 +- 0.06 4 12

TIGR03211 (4/4) catechol 2,3 dioxygenase
PF13520 (4/4) Amino acid permease
PF07729 (4/4) FCD domain
PF07690 (4/4) Major Facilitator Superfamily
PF05199 (4/4) GMC oxidoreductase
PF04303 (4/4) PrpF protein
PF03737 (4/4) Aldolase/RraA
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00732 (4/4) GMC oxidoreductase
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_groups_37627 432.30 +- 163.08 2 0 0 0 0.03 +- 0.01 2 6

PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF07994 (2/2) Myo-inositol-1-phosphate synthase
PF03664 (2/2) Glycosyl hydrolase family 62
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_10433 14.43 +- 2.92 6 0 0 0 0.18 +- 0.33 6 8

TIGR00105 (6/6) ribosomal protein bL31
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF01756 (6/6) Acyl-CoA oxidase
PF01197 (6/6) Ribosomal protein L31
PF00583 (6/6) Acetyltransferase (GNAT) family
PF01497 (4/6) Periplasmic binding protein
PF01032 (4/6) FecCD transport family
PF00005 (4/6) ABC transporter
precursor_groups_8543 46.15 +- 9.36 7 0 0 0 0.07 +- 0.06 7 5

TIGR03083 (7/7) uncharacterized Actinobacterial protein TIGR03083
PF13302 (7/7) Acetyltransferase (GNAT) domain
PF11716 (7/7) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (7/7) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (7/7) SCP-2 sterol transfer family
precursor_groups_10436 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_3952 126.97 +- 35.97 2 0 0 0 0.06 +- 0.06 2 24

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF18766 (1/2) SWI2/SNF2 ATPase
PF18050 (1/2) Cyclophilin-like family
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (1/2) XdhC Rossmann domain
PF12161 (1/2) HsdM N-terminal domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF04313 (1/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02661 (1/2) Fic/DOC family
PF02625 (1/2) XdhC and CoxI family
PF02384 (1/2) N-6 DNA Methylase
PF01799 (1/2) [2Fe-2S] binding domain
PF01738 (1/2) Dienelactone hydrolase family
PF01420 (1/2) Type I restriction modification DNA specificity domain
PF01402 (1/2) Ribbon-helix-helix protein, copG family
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
PF00069 (1/2) Protein kinase domain
precursor_groups_9816 609.89 +- 483.80 2 0 2 0 0.11 +- 0.30 2 17

TIGR03150 (2/2) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13452 (2/2) N-terminal half of MaoC dehydratase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01061 (2/2) ABC-2 type transporter
PF00856 (2/2) SET domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_77161 304.91 +- 46.91 2 0 0 0 0.02 +- 0.02 2 13

TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13466 (2/2) STAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03793 (2/2) PASTA domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (2/2) STAS domain
PF00989 (2/2) PAS fold
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00072 (2/2) Response regulator receiver domain
precursor_groups_20881 85.03 +- 2.59 2 0 0 0 0.20 +- 0.27 2 14

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13378 (2/2) Enolase C-terminal domain-like
PF09723 (2/2) Zinc ribbon domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00802 (1/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF03824 (1/2) High-affinity nickel-transport protein
precursor_groups_3958 74.91 +- 45.23 16 0 0 0 0.07 +- 0.04 16 6

TIGR04538 (16/16) cytochrome P450, cyclodipeptide synthase-associated
PF09339 (16/16) IclR helix-turn-helix domain
PF03055 (16/16) Retinal pigment epithelial membrane protein
PF01614 (16/16) Bacterial transcriptional regulator
PF00067 (16/16) Cytochrome P450
PF12680 (10/16) SnoaL-like domain
precursor_groups_77165 139.29 +- 120.71 2 0 0 0 0.06 +- 0.05 2 2

PF08386 (2/2) TAP-like protein
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_82731 59.36 +- 9.75 2 0 0 0 0.05 +- 0.04 2 14

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_45912 483.60 +- 137.88 3 0 0 0 0.05 +- 0.05 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_groups_4071 164.03 +- 90.32 7 0 0 7 0.08 +- 0.20 7 8

TIGR04085 (7/7) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (7/7) Carbamoyltransferase C-terminus
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF05977 (7/7) Transmembrane secretion effector
PF02543 (7/7) Carbamoyltransferase N-terminus
PF13186 (6/7) Iron-sulfur cluster-binding domain
PF05721 (6/7) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (4/7) Radical SAM superfamily
precursor_groups_48615 252.10 +- 137.90 2 0 0 0 0.05 +- 0.03 2 4

PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_1009 896.09 +- 960.70 60 7 53 58 0.05 +- 0.15 53 7

PF13575 (58/60) Domain of unknown function (DUF4135)
PF05147 (58/60) Lanthionine synthetase C-like protein
TIGR03897 (57/60) type 2 lantibiotic biosynthesis protein LanM
PF03412 (57/60) Peptidase C39 family
PF00664 (57/60) ABC transporter transmembrane region
PF00005 (57/60) ABC transporter
PF14867 (56/60) Lantibiotic alpha
precursor_groups_4075 170.69 +- 104.56 2 0 0 2 0.24 +- 0.06 2 35

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF16889 (2/2) Heparinase II/III N-terminus
PF16254 (2/2) Domain of unknown function (DUF4910)
PF16221 (2/2) winged helix-turn-helix
PF13727 (2/2) CoA-binding domain
PF13692 (2/2) Glycosyl transferases group 1
PF13579 (2/2) Glycosyl transferase 4-like domain
PF13537 (2/2) Glutamine amidotransferase domain
PF13489 (2/2) Methyltransferase domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13229 (2/2) Right handed beta helix region
PF08484 (2/2) C-methyltransferase C-terminal domain
PF08421 (2/2) Putative zinc binding domain
PF07940 (2/2) Heparinase II/III-like protein
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (2/2) Chain length determinant protein
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF02397 (2/2) Bacterial sugar transferase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (2/2) Asparagine synthase
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF00202 (2/2) Aminotransferase class-III
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR01221 (1/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF07690 (1/2) Major Facilitator Superfamily
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
precursor_groups_48611 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_45432 203.27 +- 174.92 2 0 1 0 0.09 +- 0.20 2 12

TIGR02483 (1/2) phosphofructokinase
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13411 (1/2) MerR HTH family regulatory protein
PF08768 (1/2) Domain of unknown function (DUF1794)
PF07690 (1/2) Major Facilitator Superfamily
PF04185 (1/2) Phosphoesterase family
PF02163 (1/2) Peptidase family M50
PF01791 (1/2) DeoC/LacD family aldolase
PF00571 (1/2) CBS domain
PF00365 (1/2) Phosphofructokinase
PF00149 (1/2) Calcineurin-like phosphoesterase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_28093 281.99 +- 177.86 4 0 4 0 0.06 +- 0.20 4 4

PF06500 (4/4) Alpha/beta hydrolase of unknown function (DUF1100)
PF01494 (4/4) FAD binding domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00198 (4/4) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_groups_45 23.91 +- 7.51 3 0 0 0 0.14 +- 0.25 3 18

TIGR02548 (2/3) CRISPR type I-E/ECOLI-associated protein CasB/Cse2
TIGR02547 (2/3) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
TIGR01907 (2/3) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
TIGR01873 (2/3) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
TIGR01869 (2/3) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
TIGR01868 (2/3) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
TIGR01596 (2/3) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (2/3) CRISPR-associated helicase Cas3
PF18395 (2/3) Cas3 C-terminal domain
PF18019 (2/3) HD domain
PF09707 (2/3) CRISPR-associated protein (Cas_Cas2CT1978)
PF09704 (2/3) CRISPR-associated protein (Cas_Cas5)
PF09485 (2/3) CRISPR-associated protein Cse2 (CRISPR_cse2)
PF09481 (2/3) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF09344 (2/3) CT1975-like protein
PF08798 (2/3) CRISPR associated protein
PF07876 (2/3) Stress responsive A/B Barrel Domain
PF05685 (2/3) Putative restriction endonuclease
precursor_groups_20531 1394.52 +- 586.12 5 0 1 0 0.01 +- 0.01 5 7

TIGR03850 (5/5) carbohydrate ABC transporter substrate-binding protein, CPR_0540 family
PF13377 (5/5) Periplasmic binding protein-like domain
PF01120 (5/5) Alpha-L-fucosidase
PF00754 (5/5) F5/8 type C domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF13416 (3/5) Bacterial extracellular solute-binding protein
precursor_groups_5071 30.77 +- 0.22 2 0 0 0 0.19 +- 0.36 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_groups_42 109.60 +- 166.65 32 0 9 0 0.11 +- 0.24 32 1

PF03777 (31/32) ChpA-C
precursor_groups_71695 1297.58 +- 1172.42 2 0 2 0 0.08 +- 0.23 2 17

TIGR01746 (2/2) thioester reductase domain
PF17920 (2/2) Tetracyclin repressor-like, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF08031 (2/2) Berberine and berberine like
PF07993 (2/2) Male sterility protein
PF04820 (2/2) Tryptophan halogenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01061 (2/2) ABC-2 type transporter
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_groups_21330 304.57 +- 328.06 4 0 4 0 0.08 +- 0.17 4 19

TIGR01733 (3/4) amino acid adenylation domain
TIGR01720 (3/4) non-ribosomal peptide synthase domain TIGR01720
PF14525 (3/4) AraC-binding-like domain
PF13349 (3/4) Putative adhesin
PF13193 (3/4) AMP-binding enzyme C-terminal domain
PF12833 (3/4) Helix-turn-helix domain
PF05977 (3/4) Transmembrane secretion effector
PF03704 (3/4) Bacterial transcriptional activator domain
PF03621 (3/4) MbtH-like protein
PF03176 (3/4) MMPL family
PF02668 (3/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01022 (3/4) Bacterial regulatory protein, arsR family
PF00975 (3/4) Thioesterase domain
PF00931 (3/4) NB-ARC domain
PF00668 (3/4) Condensation domain
PF00550 (3/4) Phosphopantetheine attachment site
PF00501 (3/4) AMP-binding enzyme
PF00486 (3/4) Transcriptional regulatory protein, C terminal
PF00144 (3/4) Beta-lactamase
precursor_groups_1396 230.74 +- 192.10 34 0 33 15 0.05 +- 0.08 34 7

PF02801 (34/34) Beta-ketoacyl synthase, C-terminal domain
PF00109 (34/34) Beta-ketoacyl synthase, N-terminal domain
PF13302 (18/34) Acetyltransferase (GNAT) domain
PF13561 (17/34) Enoyl-(Acyl carrier protein) reductase
PF13454 (17/34) FAD-NAD(P)-binding
PF00501 (17/34) AMP-binding enzyme
PF00069 (17/34) Protein kinase domain
precursor_groups_49 262.95 +- 365.34 101 8 83 61 0.08 +- 0.15 93 4

PF00005 (100/101) ABC transporter
PF00664 (97/101) ABC transporter transmembrane region
PF00069 (93/101) Protein kinase domain
PF05147 (60/101) Lanthionine synthetase C-like protein
precursor_groups_51837 1068.75 +- 101.25 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_46980 394.46 +- 277.78 3 0 0 3 0.03 +- 0.08 3 9

TIGR04188 (3/3) methyltransferase, ATP-grasp peptide maturase system
PF13521 (3/3) AAA domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00929 (3/3) Exonuclease
PF00248 (3/3) Aldo/keto reductase family
PF00005 (3/3) ABC transporter
TIGR04187 (2/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/3) putative ATP-grasp target RiPP
PF14408 (2/3) Ribosomally synthesised peptide in actinomycetes
precursor_groups_84735 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
precursor_groups_50833 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_15792 482.36 +- 190.78 4 0 0 0 0.03 +- 0.02 4 7

PF09084 (4/4) NMT1/THI5 like
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00005 (4/4) ABC transporter
TIGR01728 (3/4) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF02668 (3/4) Taurine catabolism dioxygenase TauD, TfdA family
TIGR03860 (2/4) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (2/4) Luciferase-like monooxygenase
precursor_groups_73219 456.88 +- 26.88 2 0 0 0 0.01 +- 0.01 2 6

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01756 (2/2) Acyl-CoA oxidase
PF00698 (2/2) Acyl transferase domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_5937 86.57 +- 73.42 2 0 0 0 0.12 +- 0.28 2 14

TIGR04416 (2/2) group II intron reverse transcriptase/maturase
PF13655 (2/2) N-terminal domain of reverse transcriptase
PF08388 (2/2) Group II intron, maturase-specific domain
PF01844 (2/2) HNH endonuclease
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
PF13520 (1/2) Amino acid permease
PF13493 (1/2) Domain of unknown function (DUF4118)
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02899 (1/2) Phage integrase, N-terminal SAM-like domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00589 (1/2) Phage integrase family
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_groups_739 520.62 +- 346.23 16 0 0 0 0.03 +- 0.04 16 8

PF07859 (15/16) alpha/beta hydrolase fold
PF07690 (15/16) Major Facilitator Superfamily
PF03959 (15/16) Serine hydrolase (FSH1)
PF01590 (15/16) GAF domain
PF00756 (15/16) Putative esterase
PF00561 (15/16) alpha/beta hydrolase fold
PF00196 (15/16) Bacterial regulatory proteins, luxR family
PF00144 (15/16) Beta-lactamase
precursor_groups_13825 14.27 +- 0.54 2 0 0 0 0.21 +- 0.34 2 7

TIGR01412 (2/2) Tat-translocated enzyme
PF07987 (2/2) Domain of unkown function (DUF1775)
PF05425 (2/2) Copper resistance protein D
PF04314 (2/2) Copper chaperone PCu(A)C
PF04261 (2/2) Dyp-type peroxidase family
PF04234 (2/2) CopC domain
PF02630 (2/2) SCO1/SenC
precursor_groups_53227 193.50 +- 0.00 2 0 2 0 0.03 +- 0.01 2 5

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_5936 519.00 +- 261.00 2 0 1 0 0.01 +- 0.00 2 13

PF17198 (1/2) Spirocyclase AveC-like
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08751 (1/2) TrwC relaxase
PF08659 (1/2) KR domain
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01726 (1/2) LexA DNA binding domain
PF00698 (1/2) Acyl transferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_76363 104.29 +- 51.71 2 0 0 0 0.11 +- 0.18 2 12

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13489 (2/2) Methyltransferase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_732 30.38 +- 14.86 4 0 1 0 0.22 +- 0.30 4 8

PF08924 (4/4) Domain of unknown function (DUF1906)
PF13452 (3/4) N-terminal half of MaoC dehydratase
PF12172 (3/4) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF02771 (3/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/4) Acyl-CoA dehydrogenase, middle domain
PF01796 (3/4) DUF35 OB-fold domain, acyl-CoA-associated
PF01575 (3/4) MaoC like domain
PF00441 (3/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_730 985.20 +- 669.61 29 5 24 29 0.03 +- 0.10 24 8

TIGR03897 (29/29) type 2 lantibiotic biosynthesis protein LanM
PF13575 (29/29) Domain of unknown function (DUF4135)
PF05147 (29/29) Lanthionine synthetase C-like protein
PF03412 (27/29) Peptidase C39 family
PF00664 (27/29) ABC transporter transmembrane region
PF00005 (27/29) ABC transporter
TIGR03898 (25/29) type 2 lantibiotic, mersacidin/lichenicidin family
PF12679 (17/29) ABC-2 family transporter protein
precursor_groups_70543 93.93 +- 20.22 2 0 0 0 0.04 +- 0.07 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF01234 (2/2) NNMT/PNMT/TEMT family
PF01227 (2/2) GTP cyclohydrolase I
PF00293 (2/2) NUDIX domain
precursor_groups_80510 729.09 +- 209.09 2 0 2 0 0.01 +- 0.00 2 7

PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13454 (2/2) FAD-NAD(P)-binding
PF12897 (2/2) Alanine-glyoxylate amino-transferase
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_72071 27.50 +- 0.81 2 0 0 0 0.11 +- 0.21 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_2450 38.95 +- 11.29 7 0 0 0 0.14 +- 0.14 7 18

PF13516 (7/7) Leucine Rich repeat
PF13203 (7/7) Putative metallopeptidase domain
PF09967 (7/7) VWA-like domain (DUF2201)
PF07728 (7/7) AAA domain (dynein-related subfamily)
TIGR01374 (5/7) sarcosine oxidase, delta subunit family
TIGR01373 (5/7) sarcosine oxidase, beta subunit family
TIGR01372 (5/7) sarcosine oxidase, alpha subunit family
PF17806 (5/7) Sarcosine oxidase A3 domain
PF16350 (5/7) FAD dependent oxidoreductase central domain
PF08669 (5/7) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (5/7) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (5/7) Sarcosine oxidase, gamma subunit family
PF04267 (5/7) Sarcosine oxidase, delta subunit family
PF02882 (5/7) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (5/7) Aminomethyltransferase folate-binding domain
PF01266 (5/7) FAD dependent oxidoreductase
PF00763 (5/7) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF13510 (4/7) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_16552 220.23 +- 52.97 5 0 0 0 0.03 +- 0.03 5 10

PF09339 (5/5) IclR helix-turn-helix domain
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01614 (5/5) Bacterial transcriptional regulator
PF01425 (5/5) Amidase
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF02866 (4/5) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02775 (4/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00171 (4/5) Aldehyde dehydrogenase family
PF00056 (4/5) lactate/malate dehydrogenase, NAD binding domain
precursor_groups_84073 824.48 +- 723.52 2 0 0 2 0.06 +- 0.23 2 8

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01979 (2/2) Amidohydrolase family
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_groups_31363 113.17 +- 60.16 2 0 0 0 0.10 +- 0.17 2 6

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
precursor_groups_47580 56.57 +- 33.62 3 0 0 0 0.09 +- 0.06 3 6

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13649 (3/3) Methyltransferase domain
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF01794 (3/3) Ferric reductase like transmembrane component
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_81827 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_2921 17.11 +- 7.52 4 0 0 0 0.16 +- 0.18 4 5

PF16697 (4/4) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (4/4) ABC-2 type transporter
PF00498 (4/4) FHA domain
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
precursor_groups_46566 496.17 +- 214.03 3 0 0 0 0.01 +- 0.02 3 9

PF12697 (3/3) Alpha/beta hydrolase family
PF03704 (3/3) Bacterial transcriptional activator domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02036 (3/3) SCP-2 sterol transfer family
PF01425 (3/3) Amidase
PF00899 (3/3) ThiF family
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_14447 87.80 +- 51.42 7 0 0 0 0.08 +- 0.09 7 12

TIGR03945 (7/7) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (7/7) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (7/7) amidohydrolase
TIGR00843 (7/7) benzoate transporter
PF13454 (7/7) FAD-NAD(P)-binding
PF13424 (7/7) Tetratricopeptide repeat
PF03594 (7/7) Benzoate membrane transport protein
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (7/7) Peptidase family M20/M25/M40
PF01053 (7/7) Cys/Met metabolism PLP-dependent enzyme
PF00931 (7/7) NB-ARC domain
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
precursor_groups_21688 1154.22 +- 602.60 4 0 0 0 0.02 +- 0.03 4 5

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
precursor_groups_429 181.23 +- 202.67 36 1 35 36 0.07 +- 0.19 35 7

TIGR03891 (35/36) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (35/36) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (35/36) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (35/36) Lantibiotic biosynthesis dehydratase C-term
PF02624 (35/36) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (35/36) Nitroreductase family
PF04738 (31/36) Lantibiotic dehydratase, N terminus
precursor_groups_39008 30.20 +- 1.31 2 0 0 0 0.07 +- 0.04 2 4

PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
precursor_groups_41404 254.25 +- 284.68 3 0 3 0 0.09 +- 0.24 3 9

TIGR04462 (3/3) enduracididine biosynthesis enzyme MppP
TIGR04460 (3/3) enduracididine biosynthesis enzyme MppR
PF12697 (3/3) Alpha/beta hydrolase family
PF06314 (3/3) Acetoacetate decarboxylase (ADC)
PF03621 (3/3) MbtH-like protein
PF03301 (3/3) Tryptophan 2,3-dioxygenase
PF00891 (3/3) O-methyltransferase domain
PF00535 (3/3) Glycosyl transferase family 2
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_46189 113.24 +- 45.10 3 0 0 0 0.03 +- 0.03 3 3

PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF00106 (3/3) short chain dehydrogenase
PF00067 (3/3) Cytochrome P450
precursor_groups_63755 51.07 +- 35.59 2 0 0 0 0.08 +- 0.05 2 3

TIGR01733 (2/2) amino acid adenylation domain
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_427 4379.31 +- 2105.72 31 0 31 31 0.01 +- 0.04 31 7

PF14028 (31/31) Lantibiotic biosynthesis dehydratase C-term
PF00881 (31/31) Nitroreductase family
TIGR03882 (30/31) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (30/31) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (30/31) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00005 (24/31) ABC transporter
TIGR03891 (16/31) thiopeptide-type bacteriocin biosynthesis domain
precursor_groups_36376 27.93 +- 1.01 2 0 0 0 0.22 +- 0.23 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_84981 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 2

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00069 (2/2) Protein kinase domain
precursor_groups_67099 29.10 +- 3.56 2 0 0 0 0.14 +- 0.15 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_132 103.37 +- 119.19 21 0 0 0 0.11 +- 0.17 21

No common domains found
precursor_groups_17023 181.07 +- 85.28 2 0 0 0 0.10 +- 0.11 2 20

PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
TIGR01972 (1/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF14759 (1/2) Reductase C-terminal
PF14016 (1/2) Protein of unknown function (DUF4232)
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12146 (1/2) Serine aminopeptidase, S33
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07732 (1/2) Multicopper oxidase
PF07731 (1/2) Multicopper oxidase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01545 (1/2) Cation efflux family
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00394 (1/2) Multicopper oxidase
PF00361 (1/2) Proton-conducting membrane transporter
PF00146 (1/2) NADH dehydrogenase
precursor_groups_4672 513.39 +- 333.68 17 0 0 0 0.02 +- 0.01 17 8

PF07859 (17/17) alpha/beta hydrolase fold
PF07690 (17/17) Major Facilitator Superfamily
PF03959 (17/17) Serine hydrolase (FSH1)
PF01590 (17/17) GAF domain
PF00756 (17/17) Putative esterase
PF00561 (17/17) alpha/beta hydrolase fold
PF00196 (17/17) Bacterial regulatory proteins, luxR family
PF00144 (17/17) Beta-lactamase
precursor_groups_139 97.29 +- 177.06 9 0 3 0 0.14 +- 0.23 9 1

PF18029 (5/9) Glyoxalase-like domain
precursor_groups_57162 204.54 +- 182.46 2 0 2 0 0.07 +- 0.14 2 7

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_922 38.25 +- 44.23 11 0 4 0 0.19 +- 0.23 11 7

TIGR00026 (7/11) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13589 (7/11) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF04075 (7/11) F420H(2)-dependent quinone reductase
PF00183 (7/11) Hsp90 protein
PF13483 (6/11) Beta-lactamase superfamily domain
PF01738 (6/11) Dienelactone hydrolase family
PF00355 (6/11) Rieske [2Fe-2S] domain
precursor_groups_48975 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family
precursor_groups_6152 24.51 +- 9.58 3 0 0 0 0.10 +- 0.06 3 4

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (3/3) MDMPI C-terminal domain
PF01814 (3/3) Hemerythrin HHE cation binding domain
precursor_groups_46161 264.28 +- 44.91 2 0 2 0 0.17 +- 0.30 2 23

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01361 (2/2) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (2/2) DAHP synthase ferredoxin-like domain
PF13592 (2/2) Winged helix-turn helix
PF13551 (2/2) Winged helix-turn helix
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13191 (2/2) AAA ATPase domain
PF08242 (2/2) Methyltransferase domain
PF04820 (2/2) Tryptophan halogenase
PF03621 (2/2) MbtH-like protein
PF02195 (2/2) ParB-like nuclease domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00793 (2/2) DAHP synthetase I family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_5491 13.89 +- 4.68 2 0 0 0 0.22 +- 0.04 2 3

PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_82931 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_12871 204.13 +- 182.87 2 0 0 2 0.10 +- 0.26 2 17

TIGR00702 (2/2) YcaO-type kinase domain
PF13649 (2/2) Methyltransferase domain
PF07812 (2/2) TfuA-like protein
PF07479 (2/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01210 (2/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
PF13814 (1/2) Replication-relaxation
PF13560 (1/2) Helix-turn-helix domain
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF12811 (1/2) Bax inhibitor 1 like
PF08666 (1/2) SAF domain
PF07811 (1/2) TadE-like protein
PF03704 (1/2) Bacterial transcriptional activator domain
PF01494 (1/2) FAD binding domain
PF01478 (1/2) Type IV leader peptidase family
PF01476 (1/2) LysM domain
PF00437 (1/2) Type II/IV secretion system protein
precursor_groups_19643 22.32 +- 2.76 3 0 3 0 0.13 +- 0.09 3 5

TIGR02824 (3/3) putative NAD(P)H quinone oxidoreductase, PIG3 family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07859 (3/3) alpha/beta hydrolase fold
PF01965 (3/3) DJ-1/PfpI family
PF13602 (2/3) Zinc-binding dehydrogenase
precursor_groups_47768 284.80 +- 137.64 3 0 3 0 0.02 +- 0.01 3 3

PF06912 (3/3) Protein of unknown function (DUF1275)
PF03928 (3/3) Haem-degrading
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_56365 433.58 +- 275.92 2 0 0 0 0.04 +- 0.03 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_groups_47760 170.05 +- 87.95 2 0 0 0 0.02 +- 0.03 2 4

PF12833 (2/2) Helix-turn-helix domain
PF02311 (2/2) AraC-like ligand binding domain
PF00775 (2/2) Dioxygenase
PF00293 (2/2) NUDIX domain
precursor_groups_556 355.91 +- 909.40 67 4 57 66 0.04 +- 0.10 63 3

PF00733 (66/67) Asparagine synthase
PF05402 (63/67) Coenzyme PQQ synthesis protein D (PqqD)
PF13471 (60/67) Transglutaminase-like superfamily
precursor_groups_24098 26.80 +- 4.84 4 0 4 0 0.17 +- 0.31 4 10

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF17196 (4/4) Protein of unknown function (DUF5133)
PF13964 (4/4) Kelch motif
PF09118 (4/4) Domain of unknown function (DUF1929)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF00135 (4/4) Carboxylesterase family
PF00005 (4/4) ABC transporter
PF00754 (3/4) F5/8 type C domain
PF13305 (2/4) Tetracyclin repressor-like, C-terminal domain
PF01381 (2/4) Helix-turn-helix
precursor_groups_47345 86.67 +- 0.00 2 0 2 0 0.02 +- 0.00 2 4

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_552 169.46 +- 216.39 6 0 0 0 0.08 +- 0.14 6

No common domains found
precursor_groups_53084 131.24 +- 28.41 2 0 1 0 0.16 +- 0.25 2 10

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03466 (2/2) LysR substrate binding domain
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_groups_35277 56.90 +- 12.37 3 0 0 0 0.17 +- 0.19 3 9

PF16262 (3/3) Domain of unknown function (DUF4916)
PF14230 (3/3) Domain of unknown function (DUF4333)
PF04909 (3/3) Amidohydrolase
PF04672 (3/3) S-adenosyl methyltransferase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00120 (3/3) Glutamine synthetase, catalytic domain
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
PF01494 (2/3) FAD binding domain
precursor_groups_84184 30.59 +- 5.53 2 0 0 0 0.17 +- 0.29 2 15

PF13809 (2/2) Tubulin like
PF13545 (2/2) Crp-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (2/2) Cellulose binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR00157 (1/2) ribosome small subunit-dependent GTPase A
PF17203 (1/2) Single cache domain 3
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13188 (1/2) PAS domain
PF12833 (1/2) Helix-turn-helix domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF06029 (1/2) AlkA N-terminal domain
PF03193 (1/2) RsgA GTPase
PF02805 (1/2) Metal binding domain of Ada
PF01590 (1/2) GAF domain
precursor_groups_5653 964.27 +- 325.73 2 0 0 0 0.01 +- 0.02 2 12

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_71511 106.72 +- 48.08 2 0 2 0 0.06 +- 0.06 2 9

TIGR01686 (2/2) FkbH domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01596 (2/2) O-methyltransferase
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_29221 309.60 +- 206.40 2 0 0 2 0.03 +- 0.02 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF13847 (1/2) Methyltransferase domain
precursor_groups_45090 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_groups_47165 2433.09 +- 685.07 3 0 3 3 0.01 +- 0.01 3 14

TIGR01733 (3/3) amino acid adenylation domain
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF18130 (3/3) ATP-grasp N-terminal domain
PF13537 (3/3) Glutamine amidotransferase domain
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03547 (3/3) Membrane transport protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01063 (3/3) Amino-transferase class IV
PF00733 (3/3) Asparagine synthase
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00144 (3/3) Beta-lactamase
precursor_groups_2180 13.15 +- 4.71 7 0 0 0 0.21 +- 0.11 7 2

PF03067 (7/7) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (7/7) SPFH domain / Band 7 family
precursor_groups_35297 1892.58 +- 456.15 3 0 0 0 0.01 +- 0.01 3 9

PF13814 (3/3) Replication-relaxation
PF13406 (3/3) Transglycosylase SLT domain
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_groups_70103 193.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 4

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_39352 131.88 +- 49.18 3 0 0 0 0.03 +- 0.02 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF02734 (3/3) DAK2 domain
PF02733 (3/3) Dak1 domain
PF00083 (3/3) Sugar (and other) transporter
TIGR02365 (2/3) dihydroxyacetone kinase, L subunit
precursor_groups_36070 189.74 +- 14.16 2 0 0 0 0.07 +- 0.06 2 7

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_75261 419.50 +- 204.50 2 0 0 0 0.02 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
PF13546 (1/2) DDE superfamily endonuclease
precursor_groups_76081 174.34 +- 16.77 2 0 0 0 0.05 +- 0.03 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
precursor_groups_5375 20.81 +- 7.45 2 0 0 0 0.17 +- 0.13 2 8

TIGR00045 (2/2) glycerate kinase
PF02595 (2/2) Glycerate kinase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (2/2) Sodium:sulfate symporter transmembrane region
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
precursor_groups_35615 36.10 +- 11.29 2 0 0 2 0.13 +- 0.14 2 12

TIGR03104 (2/2) asparagine synthase family amidotransferase
TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13537 (2/2) Glutamine amidotransferase domain
PF13466 (2/2) STAS domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00733 (2/2) Asparagine synthase
PF00326 (2/2) Prolyl oligopeptidase family
TIGR02050 (1/2) carboxylate-amine ligase, YbdK family
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
precursor_groups_55920 80.48 +- 6.19 2 0 0 0 0.03 +- 0.01 2 4

PF08592 (2/2) Domain of unknown function (DUF1772)
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF00394 (2/2) Multicopper oxidase
precursor_groups_72119 425.70 +- 38.70 2 0 2 2 0.02 +- 0.02 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
precursor_groups_28866 1154.22 +- 602.60 4 0 0 0 0.02 +- 0.03 4 5

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
precursor_groups_28864 177.11 +- 82.89 2 0 2 0 0.09 +- 0.13 2 13

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_47015 138.21 +- 87.51 3 0 3 3 0.12 +- 0.24 3 12

TIGR04188 (3/3) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (3/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (3/3) putative ATP-grasp target RiPP
PF14408 (3/3) Ribosomally synthesised peptide in actinomycetes
PF13581 (3/3) Histidine kinase-like ATPase domain
PF07969 (3/3) Amidohydrolase family
PF07702 (3/3) UTRA domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01032 (3/3) FecCD transport family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
precursor_groups_56901 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_27961 1293.33 +- 4.71 3 0 3 3 0.01 +- 0.00 3 6

PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF01928 (3/3) CYTH domain
PF01523 (3/3) Putative modulator of DNA gyrase
PF01061 (3/3) ABC-2 type transporter
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_groups_31963 43.48 +- 6.72 3 0 3 0 0.09 +- 0.15 3 8

TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR02353 (3/3) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_18590 40.22 +- 17.68 5 0 0 0 0.11 +- 0.06 5 10

TIGR00745 (5/5) 2-dehydropantoate 2-reductase
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13412 (5/5) Winged helix-turn-helix DNA-binding
PF13404 (5/5) AsnC-type helix-turn-helix domain
PF08546 (5/5) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (5/5) Major Facilitator Superfamily
PF02558 (5/5) Ketopantoate reductase PanE/ApbA
PF01546 (5/5) Peptidase family M20/M25/M40
PF01522 (5/5) Polysaccharide deacetylase
PF01037 (5/5) Lrp/AsnC ligand binding domain
precursor_groups_22499 71.13 +- 19.78 3 0 0 0 0.23 +- 0.14 3 8

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF08445 (3/3) FR47-like protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00296 (3/3) Luciferase-like monooxygenase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_groups_15353 69.73 +- 33.61 5 0 0 0 0.04 +- 0.04 5 2

PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00877 (5/5) NlpC/P60 family
precursor_groups_20212 345.44 +- 299.56 2 0 1 0 0.02 +- 0.02 2 12

PF17885 (1/2) Styrene monooxygenase A putative substrate binding domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF06912 (1/2) Protein of unknown function (DUF1275)
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02308 (1/2) MgtC family
PF01566 (1/2) Natural resistance-associated macrophage protein
PF00501 (1/2) AMP-binding enzyme
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00221 (1/2) Aromatic amino acid lyase
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_22492 124.63 +- 52.35 3 0 0 0 0.04 +- 0.05 3 3

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF13460 (2/3) NAD(P)H-binding
PF00561 (2/3) alpha/beta hydrolase fold
precursor_groups_7433 2526.98 +- 1499.77 7 0 7 7 0.01 +- 0.01 7 8

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (7/7) Nitroreductase family
PF00296 (7/7) Luciferase-like monooxygenase
precursor_groups_28885 75.79 +- 20.96 4 0 3 0 0.06 +- 0.06 4 9

PF11512 (4/4) Agrobacterium tumefaciens protein Atu4866
PF07690 (4/4) Major Facilitator Superfamily
PF00550 (4/4) Phosphopantetheine attachment site
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF01370 (3/4) NAD dependent epimerase/dehydratase family
PF00975 (3/4) Thioesterase domain
PF00501 (3/4) AMP-binding enzyme
PF13480 (2/4) Acetyltransferase (GNAT) domain
PF00155 (2/4) Aminotransferase class I and II
precursor_groups_61393 344.00 +- 136.00 2 0 0 0 0.03 +- 0.03 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF01553 (2/2) Acyltransferase
PF01148 (2/2) Cytidylyltransferase family
PF01066 (2/2) CDP-alcohol phosphatidyltransferase
PF12840 (1/2) Helix-turn-helix domain
precursor_groups_4654 291.57 +- 235.66 16 0 16 0 0.05 +- 0.10 16 10

TIGR01821 (16/16) 5-aminolevulinic acid synthase
PF16884 (16/16) N-terminal domain of oxidoreductase
PF08545 (16/16) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (16/16) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (16/16) Major Facilitator Superfamily
PF02668 (16/16) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (16/16) Aminotransferase class I and II
PF00107 (16/16) Zinc-binding dehydrogenase
TIGR01891 (10/16) amidohydrolase
PF01546 (10/16) Peptidase family M20/M25/M40
precursor_groups_61821 666.40 +- 418.72 2 0 0 0 0.03 +- 0.06 2 21

TIGR03217 (2/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/2) acetaldehyde dehydrogenase (acetylating)
TIGR01088 (2/2) 3-dehydroquinate dehydratase, type II
PF18317 (2/2) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (2/2) IclR helix-turn-helix domain
PF09290 (2/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08501 (2/2) Shikimate dehydrogenase substrate binding domain
PF07836 (2/2) DmpG-like communication domain
PF07690 (2/2) Major Facilitator Superfamily
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01220 (2/2) Dehydroquinase class II
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (2/2) HMGL-like
PF00083 (2/2) Sugar (and other) transporter
PF01488 (1/2) Shikimate / quinate 5-dehydrogenase
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00665 (1/2) Integrase core domain
precursor_groups_55033 282.30 +- 147.70 2 0 1 0 0.04 +- 0.06 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF02633 (2/2) Creatinine amidohydrolase
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00459 (1/2) Inositol monophosphatase family
precursor_groups_84741 18.22 +- 0.89 2 0 0 0 0.11 +- 0.02 2 2

PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (2/2) Dehydratase family
precursor_groups_78243 118.08 +- 90.30 2 0 0 2 0.12 +- 0.26 2 7

TIGR04188 (2/2) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14408 (2/2) Ribosomally synthesised peptide in actinomycetes
PF13560 (2/2) Helix-turn-helix domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_59920 404.71 +- 25.29 2 0 0 0 0.02 +- 0.01 2 4

PF09084 (2/2) NMT1/THI5 like
PF01636 (2/2) Phosphotransferase enzyme family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_22428 812.16 +- 80.91 2 0 2 0 0.02 +- 0.04 2 10

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03412 (2/2) Peptidase C39 family
PF01636 (2/2) Phosphotransferase enzyme family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_35054 239.74 +- 77.74 3 0 2 0 0.04 +- 0.02 3 3

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF07944 (3/3) Beta-L-arabinofuranosidase, GH127
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_18309 62.86 +- 0.00 2 0 2 0 0.19 +- 0.28 2 8

TIGR03571 (2/2) luciferase-type oxidoreductase, BA3436 family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (2/2) SnoaL-like domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03928 (2/2) Haem-degrading
PF00857 (2/2) Isochorismatase family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_24437 230.33 +- 112.90 3 0 3 0 0.02 +- 0.01 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13483 (3/3) Beta-lactamase superfamily domain
PF07467 (3/3) Beta-lactamase inhibitor (BLIP)
PF04989 (3/3) Cephalosporin hydroxylase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
precursor_groups_42194 193.50 +- 64.50 2 0 2 0 0.01 +- 0.01 2 2

PF07993 (2/2) Male sterility protein
PF00202 (2/2) Aminotransferase class-III
precursor_groups_42622 129.73 +- 81.36 2 0 0 0 0.05 +- 0.03 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF00667 (2/2) FAD binding domain
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00067 (2/2) Cytochrome P450
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF01670 (1/2) Glycosyl hydrolase family 12
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_25437 38.65 +- 9.19 3 0 0 0 0.20 +- 0.21 3 6

PF00128 (3/3) Alpha amylase, catalytic domain
PF12697 (2/3) Alpha/beta hydrolase family
PF11941 (2/3) Domain of unknown function (DUF3459)
PF01553 (2/3) Acyltransferase
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_25970 139.95 +- 120.14 4 0 0 0 0.08 +- 0.12 4 3

PF02782 (4/4) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (4/4) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (4/4) Histidine phosphatase superfamily (branch 1)
precursor_groups_64010 117.00 +- 13.00 2 0 2 0 0.02 +- 0.01 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_22657 29.74 +- 3.21 3 0 0 0 0.09 +- 0.08 3 4

PF09848 (3/3) Uncharacterized conserved protein (DUF2075)
PF09992 (2/3) Phosphodiester glycosidase
PF05036 (2/3) Sporulation related domain
PF00756 (2/3) Putative esterase
precursor_groups_67712 520.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 2

PF13649 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
precursor_groups_2142 207.65 +- 141.56 10 0 0 0 0.05 +- 0.14 10 3

PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF01039 (10/10) Carboxyl transferase domain
PF00501 (10/10) AMP-binding enzyme
precursor_groups_30740 54.24 +- 29.73 4 0 0 0 0.18 +- 0.19 4 5

TIGR00996 (4/4) virulence factor Mce family protein
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter
precursor_groups_16307 109.83 +- 98.18 6 0 5 0 0.07 +- 0.08 6 6

PF07690 (6/6) Major Facilitator Superfamily
PF05893 (6/6) Acyl-CoA reductase (LuxC)
PF04443 (6/6) Acyl-protein synthetase, LuxE
PF01553 (6/6) Acyltransferase
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00501 (5/6) AMP-binding enzyme
precursor_groups_11465 400.93 +- 119.98 7 0 7 7 0.01 +- 0.01 7 3

PF13471 (7/7) Transglutaminase-like superfamily
PF00733 (7/7) Asparagine synthase
PF00005 (6/7) ABC transporter
precursor_groups_79821 121.89 +- 25.99 2 0 1 0 0.13 +- 0.17 2 14

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF03713 (2/2) Domain of unknown function (DUF305)
PF00877 (2/2) NlpC/P60 family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00146 (2/2) NADH dehydrogenase
PF00067 (2/2) Cytochrome P450
TIGR01085 (1/2) UDP-N-acetylmuramyl-tripeptide synthetase
PF08245 (1/2) Mur ligase middle domain
PF02875 (1/2) Mur ligase family, glutamate ligase domain
PF02342 (1/2) TerD domain
precursor_groups_11462 56.89 +- 19.03 4 0 0 0 0.13 +- 0.16 4 4

TIGR01484 (4/4) HAD hydrolase, family IIB
PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF04149 (4/4) Domain of unknown function (DUF397)
PF00353 (4/4) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_groups_11460 54.95 +- 21.06 4 0 0 0 0.15 +- 0.16 4 8

PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF08533 (4/4) Beta-galactosidase C-terminal domain
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF13416 (3/4) Bacterial extracellular solute-binding protein
PF02012 (2/4) BNR/Asp-box repeat
precursor_groups_73456 181.48 +- 56.68 2 0 0 0 0.02 +- 0.03 2 5

PF13458 (2/2) Periplasmic binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
precursor_groups_17 276.11 +- 570.51 275 0 139 23 0.09 +- 0.19 275 2

PF00067 (237/275) Cytochrome P450
PF13370 (179/275) 4Fe-4S single cluster domain of Ferredoxin I
precursor_groups_83777 128.36 +- 2.85 2 0 2 0 0.14 +- 0.12 2 6

PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00293 (2/2) NUDIX domain
precursor_groups_67117 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_1448 129.25 +- 115.82 18 0 0 0 0.08 +- 0.08 18 6

PF05922 (18/18) Peptidase inhibitor I9
PF00082 (18/18) Subtilase family
PF14534 (17/18) Domain of unknown function (DUF4440)
PF08002 (17/18) Protein of unknown function (DUF1697)
PF00664 (11/18) ABC transporter transmembrane region
PF00005 (10/18) ABC transporter
precursor_groups_6912 319.63 +- 209.86 4 0 4 4 0.06 +- 0.15 4 5

TIGR03558 (4/4) luciferase family oxidoreductase, group 1
PF07690 (4/4) Major Facilitator Superfamily
PF05147 (4/4) Lanthionine synthetase C-like protein
PF00296 (4/4) Luciferase-like monooxygenase
PF00069 (2/4) Protein kinase domain
precursor_groups_8617 50.74 +- 14.21 2 0 0 0 0.12 +- 0.12 2 6

PF08751 (2/2) TrwC relaxase
PF08007 (2/2) Cupin superfamily protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00248 (2/2) Aldo/keto reductase family
PF01545 (1/2) Cation efflux family
precursor_groups_66935 388.00 +- 128.00 2 0 2 0 0.02 +- 0.01 2 7

PF13394 (2/2) 4Fe-4S single cluster domain
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00478 (2/2) IMP dehydrogenase / GMP reductase domain
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_78069 32.11 +- 2.01 2 0 0 0 0.09 +- 0.11 2 4

PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_groups_6917 143.44 +- 114.56 2 0 2 0 0.04 +- 0.04 2 4

PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01565 (2/2) FAD binding domain
precursor_groups_6914 73.12 +- 24.38 2 0 0 0 0.03 +- 0.02 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein
precursor_groups_55103 126.04 +- 6.73 2 0 0 0 0.13 +- 0.24 2 9

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_43861 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_groups_6918 339.55 +- 177.50 10 0 10 0 0.04 +- 0.02 10 9

PF16861 (10/10) Carbamoyltransferase C-terminus
PF13560 (10/10) Helix-turn-helix domain
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF02543 (10/10) Carbamoyltransferase N-terminus
PF00668 (10/10) Condensation domain
PF00664 (10/10) ABC transporter transmembrane region
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF00005 (10/10) ABC transporter
precursor_groups_55458 64.56 +- 19.01 2 0 2 2 0.10 +- 0.24 2 16

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05173 (2/2) Dihydrodipicolinate reductase, C-terminus
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00881 (2/2) Nitroreductase family
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR02246 (1/2) conserved hypothetical protein
TIGR01048 (1/2) diaminopimelate decarboxylase
PF17837 (1/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF14534 (1/2) Domain of unknown function (DUF4440)
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01113 (1/2) Dihydrodipicolinate reductase, N-terminus
PF00899 (1/2) ThiF family
PF00581 (1/2) Rhodanese-like domain
precursor_groups_22018 51.70 +- 17.17 5 0 3 0 0.07 +- 0.11 5 5

PF13305 (5/5) Tetracyclin repressor-like, C-terminal domain
PF00561 (5/5) alpha/beta hydrolase fold
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00150 (5/5) Cellulase (glycosyl hydrolase family 5)
PF18564 (4/5) Glycoside hydrolase family 5 C-terminal domain
precursor_groups_55858 77.88 +- 46.92 2 0 0 0 0.06 +- 0.06 2 6

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00293 (2/2) NUDIX domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF08533 (1/2) Beta-galactosidase C-terminal domain
PF08532 (1/2) Beta-galactosidase trimerisation domain
PF02449 (1/2) Beta-galactosidase
precursor_groups_76427 594.00 +- 121.00 2 0 0 0 0.02 +- 0.00 2 6

PF13458 (2/2) Periplasmic binding protein
PF12399 (2/2) Branched-chain amino acid ATP-binding cassette transporter
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01565 (2/2) FAD binding domain
PF00005 (2/2) ABC transporter
precursor_groups_78481 344.00 +- 172.00 2 0 0 0 0.02 +- 0.02 2 2

PF03972 (2/2) MmgE/PrpD family
PF00857 (2/2) Isochorismatase family
precursor_groups_14939 129.00 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF01833 (2/2) IPT/TIG domain
PF01636 (2/2) Phosphotransferase enzyme family
PF00293 (2/2) NUDIX domain
precursor_groups_12664 2666.00 +- 121.62 3 0 3 3 0.01 +- 0.00 3 5

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF00005 (3/3) ABC transporter
precursor_groups_19353 166.53 +- 82.45 5 0 0 0 0.02 +- 0.03 5 3

PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00877 (5/5) NlpC/P60 family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
precursor_groups_31776 10.11 +- 0.29 2 0 0 0 0.20 +- 0.01 2 5

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
precursor_groups_43461 146.45 +- 50.79 2 0 0 0 0.11 +- 0.03 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (2/2) FMN reductase
PF09084 (2/2) NMT1/THI5 like
PF03358 (2/2) NADPH-dependent FMN reductase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_7531 22.00 +- 2.00 2 0 0 0 0.14 +- 0.22 2 6

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF13377 (2/2) Periplasmic binding protein-like domain
PF02803 (2/2) Thiolase, C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00108 (2/2) Thiolase, N-terminal domain
precursor_groups_30358 52.42 +- 4.72 2 0 0 0 0.10 +- 0.15 2 11

TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (2/2) CoA-binding domain
PF13692 (2/2) Glycosyl transferases group 1
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13439 (2/2) Glycosyltransferase Family 4
PF04932 (2/2) O-Antigen ligase
PF03023 (2/2) Lipid II flippase MurJ
PF02706 (2/2) Chain length determinant protein
PF02397 (2/2) Bacterial sugar transferase
PF01522 (2/2) Polysaccharide deacetylase
PF00534 (2/2) Glycosyl transferases group 1
precursor_groups_3729 394.26 +- 108.83 3 0 0 0 0.05 +- 0.15 3 12

PF13814 (3/3) Replication-relaxation
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF13406 (2/3) Transglycosylase SLT domain
PF10935 (2/3) Protein of unknown function (DUF2637)
precursor_groups_68570 134.33 +- 125.67 2 0 0 0 0.12 +- 0.25 2 4

TIGR04444 (2/2) chorismatase, FkbO/Hyg5 family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00892 (2/2) EamA-like transporter family
PF00501 (2/2) AMP-binding enzyme
precursor_groups_30357 140.58 +- 23.65 4 0 0 4 0.02 +- 0.01 4 4

PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF04339 (4/4) Peptidogalycan biosysnthesis/recognition
PF04055 (4/4) Radical SAM superfamily
PF00303 (4/4) Thymidylate synthase
precursor_groups_37430 147.46 +- 15.60 3 0 2 0 0.02 +- 0.01 3 6

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF02805 (3/3) Metal binding domain of Ada
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00501 (3/3) AMP-binding enzyme
precursor_groups_30351 20.99 +- 0.84 4 0 0 0 0.14 +- 0.21 4 8

TIGR01695 (4/4) murein biosynthesis integral membrane protein MurJ
PF03023 (4/4) Lipid II flippase MurJ
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
precursor_groups_30353 374.56 +- 149.41 4 0 3 0 0.02 +- 0.06 4 7

PF13649 (4/4) Methyltransferase domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF12850 (4/4) Calcineurin-like phosphoesterase superfamily domain
PF04389 (4/4) Peptidase family M28
PF01663 (4/4) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00334 (4/4) Nucleoside diphosphate kinase
PF00155 (4/4) Aminotransferase class I and II
precursor_groups_7086 11.85 +- 0.99 2 0 0 0 0.17 +- 0.17 2 5

PF16697 (2/2) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_7085 849.34 +- 1079.38 12 0 0 0 0.02 +- 0.02 12 6

TIGR03930 (12/12) WXG100 family type VII secretion target
TIGR03919 (12/12) type VII secretion protein EccB
PF06013 (12/12) Proteins of 100 residues with WXG
PF05108 (12/12) Type VII secretion system ESX-1, transport TM domain B
TIGR03921 (11/12) type VII secretion-associated serine protease mycosin
PF00082 (11/12) Subtilase family
precursor_groups_7081 91.72 +- 117.35 10 0 10 0 0.10 +- 0.21 10 14

TIGR01746 (10/10) thioester reductase domain
TIGR01733 (10/10) amino acid adenylation domain
TIGR01720 (10/10) non-ribosomal peptide synthase domain TIGR01720
PF14433 (10/10) SUKH-3 immunity protein
PF13302 (10/10) Acetyltransferase (GNAT) domain
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF09339 (10/10) IclR helix-turn-helix domain
PF07993 (10/10) Male sterility protein
PF05448 (10/10) Acetyl xylan esterase (AXE1)
PF01614 (10/10) Bacterial transcriptional regulator
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF03621 (6/10) MbtH-like protein
precursor_groups_47564 237.28 +- 57.47 3 0 0 0 0.06 +- 0.09 3 15

TIGR01451 (3/3) conserved repeat domain
TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF18029 (3/3) Glyoxalase-like domain
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF12831 (3/3) FAD dependent oxidoreductase
PF07971 (3/3) Glycosyl hydrolase family 92
PF07730 (3/3) Histidine kinase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_6130 31.90 +- 14.17 5 0 0 0 0.14 +- 0.24 5 5

PF13302 (4/5) Acetyltransferase (GNAT) domain
PF12172 (4/5) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08445 (4/5) FR47-like protein
PF07681 (4/5) DoxX
PF01796 (4/5) DUF35 OB-fold domain, acyl-CoA-associated
precursor_groups_12208 75.72 +- 9.61 8 0 8 0 0.04 +- 0.05 8 5

PF13394 (8/8) 4Fe-4S single cluster domain
PF13377 (8/8) Periplasmic binding protein-like domain
PF01242 (8/8) 6-pyruvoyl tetrahydropterin synthase
PF01227 (8/8) GTP cyclohydrolase I
PF00356 (8/8) Bacterial regulatory proteins, lacI family
precursor_groups_43009 109.51 +- 1.92 2 0 0 0 0.04 +- 0.03 2 6

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family
precursor_groups_12623 1753.66 +- 852.81 8 0 8 0 0.01 +- 0.01 8 11

PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13535 (8/8) ATP-grasp domain
PF07690 (8/8) Major Facilitator Superfamily
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF00975 (8/8) Thioesterase domain
PF00698 (8/8) Acyl transferase domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (7/8) amino acid adenylation domain
PF13193 (7/8) AMP-binding enzyme C-terminal domain
PF00501 (7/8) AMP-binding enzyme
precursor_groups_65 184.11 +- 475.42 17 0 9 0 0.12 +- 0.24 17 2

PF00313 (16/17) 'Cold-shock' DNA-binding domain
PF07690 (11/17) Major Facilitator Superfamily
precursor_groups_43003 1202.14 +- 87.86 2 0 2 0 0.01 +- 0.00 2 8

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
precursor_groups_12201 64.26 +- 49.54 8 0 0 0 0.09 +- 0.11 8 8

TIGR04350 (8/8) putative C-S lyase
PF18105 (8/8) PGM1 C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF00155 (8/8) Aminotransferase class I and II
PF14100 (5/8) Methane oxygenase PmoA
PF02894 (5/8) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/8) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_1833 596.25 +- 564.95 29 0 28 29 0.02 +- 0.02 29 4

PF00733 (29/29) Asparagine synthase
PF13471 (28/29) Transglutaminase-like superfamily
PF00005 (28/29) ABC transporter
PF01546 (16/29) Peptidase family M20/M25/M40
precursor_groups_22275 218.13 +- 148.93 2 0 0 2 0.03 +- 0.07 2 15

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
PF18181 (2/2) SMODS and SLOG-associating 2TM effector domain 1
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13191 (2/2) AAA ATPase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF07729 (1/2) FCD domain
PF00754 (1/2) F5/8 type C domain
precursor_groups_31156 28.59 +- 7.25 4 0 0 0 0.07 +- 0.03 4 6

TIGR00229 (4/4) PAS domain S-box protein
PF08448 (4/4) PAS fold
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF01590 (4/4) GAF domain
PF00989 (4/4) PAS fold
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_60279 204.23 +- 0.06 2 0 0 2 0.10 +- 0.29 2 11

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR01343 (2/2) homoaconitate hydratase family protein
TIGR00049 (2/2) iron-sulfur cluster assembly accessory protein
PF08241 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF01521 (2/2) Iron-sulphur cluster biosynthesis
PF01106 (2/2) NifU-like domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_68497 54.28 +- 11.99 2 0 0 0 0.23 +- 0.29 2 16

TIGR03557 (2/2) F420-dependent oxidoreductase, G6PDH family
PF13244 (2/2) Domain of unknown function (DUF4040)
PF09364 (2/2) XFP N-terminal domain
PF09363 (2/2) XFP C-terminal domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03894 (2/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00667 (2/2) FAD binding domain
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00384 (2/2) Molybdopterin oxidoreductase
PF00361 (2/2) Proton-conducting membrane transporter
PF00296 (2/2) Luciferase-like monooxygenase
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
precursor_groups_26790 49.23 +- 4.32 4 0 4 0 0.08 +- 0.13 4 6

PF13243 (4/4) Squalene-hopene cyclase C-terminal domain
PF00754 (4/4) F5/8 type C domain
PF00432 (4/4) Prenyltransferase and squalene oxidase repeat
PF00067 (4/4) Cytochrome P450
TIGR03356 (3/4) beta-galactosidase
PF00232 (3/4) Glycosyl hydrolase family 1
precursor_groups_11962 410.80 +- 272.14 2 0 2 0 0.03 +- 0.03 2 18

TIGR02353 (1/2) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (1/2) amino acid adenylation domain
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF13343 (1/2) Bacterial extracellular solute-binding protein
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12728 (1/2) Helix-turn-helix domain
PF08402 (1/2) TOBE domain
PF08241 (1/2) Methyltransferase domain
PF06236 (1/2) Tyrosinase co-factor MelC1
PF03459 (1/2) TOBE domain
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF00932 (1/2) Lamin Tail Domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter
precursor_groups_7396 170.04 +- 70.06 10 0 0 0 0.07 +- 0.04 10 8

PF10633 (10/10) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (10/10) Alpha mannosidase middle domain
PF01418 (10/10) Helix-turn-helix domain, rpiR family
PF01380 (10/10) SIS domain
PF01074 (10/10) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF13416 (5/10) Bacterial extracellular solute-binding protein
PF01547 (5/10) Bacterial extracellular solute-binding protein
precursor_groups_7395 567.51 +- 160.96 2 0 0 2 0.02 +- 0.02 2 9

TIGR04188 (2/2) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14408 (2/2) Ribosomally synthesised peptide in actinomycetes
PF13521 (2/2) AAA domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00929 (2/2) Exonuclease
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_groups_3540 16.92 +- 2.81 20 0 20 0 0.18 +- 0.20 20 4

PF11991 (20/20) Tryptophan dimethylallyltransferase
PF05331 (20/20) Protein of unknown function (DUF742)
PF03259 (20/20) Roadblock/LC7 domain
PF03029 (20/20) Conserved hypothetical ATP binding protein
precursor_groups_48776 276.53 +- 70.13 2 0 0 0 0.03 +- 0.04 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_1571 247.05 +- 133.36 29 0 29 0 0.13 +- 0.24 29 23

TIGR01361 (29/29) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (29/29) DAHP synthase ferredoxin-like domain
PF13592 (29/29) Winged helix-turn helix
PF13551 (29/29) Winged helix-turn helix
PF13191 (29/29) AAA ATPase domain
PF02195 (29/29) ParB-like nuclease domain
PF00793 (29/29) DAHP synthetase I family
PF00668 (29/29) Condensation domain
PF00664 (29/29) ABC transporter transmembrane region
PF00501 (29/29) AMP-binding enzyme
PF00196 (29/29) Bacterial regulatory proteins, luxR family
PF00005 (29/29) ABC transporter
TIGR01733 (28/29) amino acid adenylation domain
TIGR01720 (28/29) non-ribosomal peptide synthase domain TIGR01720
PF13193 (28/29) AMP-binding enzyme C-terminal domain
PF00550 (28/29) Phosphopantetheine attachment site
PF13370 (25/29) 4Fe-4S single cluster domain of Ferredoxin I
PF04820 (25/29) Tryptophan halogenase
PF03621 (25/29) MbtH-like protein
PF00975 (25/29) Thioesterase domain
PF00067 (25/29) Cytochrome P450
PF00999 (24/29) Sodium/hydrogen exchanger family
PF13649 (16/29) Methyltransferase domain
precursor_groups_393 9.17 +- 0.95 3 0 1 0 0.22 +- 0.20 3 9

PF12728 (3/3) Helix-turn-helix domain
PF10935 (3/3) Protein of unknown function (DUF2637)
PF05122 (3/3) Mobile element transfer protein
PF01580 (3/3) FtsK/SpoIIIE family
PF00589 (3/3) Phage integrase family
TIGR01764 (2/3) DNA binding domain, excisionase family
TIGR00254 (2/3) diguanylate cyclase (GGDEF) domain
PF14659 (2/3) Phage integrase, N-terminal SAM-like domain
PF00990 (2/3) Diguanylate cyclase, GGDEF domain
precursor_groups_15911 43.70 +- 19.22 4 0 0 0 0.15 +- 0.15 4 3

PF05425 (4/4) Copper resistance protein D
PF02515 (4/4) CoA-transferase family III
PF00082 (4/4) Subtilase family
precursor_groups_3894 14.24 +- 5.41 9 0 0 0 0.17 +- 0.07 9 5

TIGR03802 (9/9) aspartate-alanine antiporter
TIGR03801 (9/9) aspartate 4-decarboxylase
PF06826 (9/9) Predicted Permease Membrane Region
PF02080 (9/9) TrkA-C domain
PF00155 (9/9) Aminotransferase class I and II
precursor_groups_58294 128.17 +- 24.49 2 0 2 2 0.13 +- 0.29 2 19

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13424 (2/2) Tetratricopeptide repeat
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08007 (2/2) Cupin superfamily protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00931 (2/2) NB-ARC domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_58293 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_groups_26770 30.56 +- 12.87 4 0 0 0 0.13 +- 0.10 4 5

PF18603 (3/4) L-amino acid ligase C-terminal domain 2
PF13649 (3/4) Methyltransferase domain
PF13535 (3/4) ATP-grasp domain
PF07690 (3/4) Major Facilitator Superfamily
PF00291 (3/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_7889 725.24 +- 513.13 11 0 0 0 0.03 +- 0.04 11 8

PF13561 (11/11) Enoyl-(Acyl carrier protein) reductase
PF09084 (11/11) NMT1/THI5 like
PF03737 (11/11) Aldolase/RraA
PF03466 (11/11) LysR substrate binding domain
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF00294 (11/11) pfkB family carbohydrate kinase
PF00126 (11/11) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (11/11) ABC transporter
precursor_groups_48573 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_38969 241.98 +- 107.49 3 0 0 0 0.03 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_groups_20656 21.93 +- 5.77 3 0 0 0 0.16 +- 0.16 3 10

PF17755 (3/3) UvrA DNA-binding domain
PF13613 (3/3) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (3/3) DDE superfamily endonuclease
TIGR01068 (2/3) thioredoxin
PF10431 (2/3) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/3) AAA domain (Cdc48 subfamily)
PF02148 (2/3) Zn-finger in ubiquitin-hydrolases and other protein
PF00085 (2/3) Thioredoxin
PF00027 (2/3) Cyclic nucleotide-binding domain
precursor_groups_7880 216.67 +- 43.33 2 0 2 0 0.01 +- 0.00 2 3

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_23277 332.78 +- 96.11 5 0 5 0 0.12 +- 0.25 5 33

TIGR01902 (5/5) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (5/5) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (5/5) amino acid adenylation domain
TIGR00768 (5/5) alpha-L-glutamate ligase, RimK family
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF14765 (5/5) Polyketide synthase dehydratase
PF13602 (5/5) Zinc-binding dehydrogenase
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08990 (5/5) Erythronolide synthase docking
PF08659 (5/5) KR domain
PF08443 (5/5) RimK-like ATP-grasp domain
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF08028 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF02779 (5/5) Transketolase, pyrimidine binding domain
PF01546 (5/5) Peptidase family M20/M25/M40
PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF01118 (5/5) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (5/5) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (5/5) Thioesterase domain
PF00698 (5/5) Acyl transferase domain
PF00696 (5/5) Amino acid kinase family
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00456 (5/5) Transketolase, thiamine diphosphate binding domain
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
PF00857 (4/5) Isochorismatase family
precursor_groups_17743 51.19 +- 20.24 5 0 0 0 0.18 +- 0.21 5 15

PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (5/5) Acetyltransferase (GNAT) family
TIGR02980 (3/5) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF07228 (3/5) Stage II sporulation protein E (SpoIIE)
PF05227 (3/5) CHASE3 domain
PF04545 (3/5) Sigma-70, region 4
PF04542 (3/5) Sigma-70 region 2
PF04539 (3/5) Sigma-70 region 3
PF02518 (3/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01047 (3/5) MarR family
PF00672 (3/5) HAMP domain
PF00512 (3/5) His Kinase A (phospho-acceptor) domain
PF00072 (3/5) Response regulator receiver domain
precursor_groups_7713 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_groups_7248 83.91 +- 57.91 2 0 0 0 0.09 +- 0.12 2 9

TIGR03558 (1/2) luciferase family oxidoreductase, group 1
PF18029 (1/2) Glyoxalase-like domain
PF09948 (1/2) Predicted metal-binding integral membrane protein (DUF2182)
PF07040 (1/2) Protein of unknown function (DUF1326)
PF03176 (1/2) MMPL family
PF01636 (1/2) Phosphotransferase enzyme family
PF01042 (1/2) Endoribonuclease L-PSP
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
precursor_groups_12519 77.76 +- 20.73 5 0 5 0 0.14 +- 0.22 5 13

TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF13581 (5/5) Histidine kinase-like ATPase domain
PF13302 (5/5) Acetyltransferase (GNAT) domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08447 (5/5) PAS fold
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00144 (5/5) Beta-lactamase
PF00067 (5/5) Cytochrome P450
PF03621 (4/5) MbtH-like protein
precursor_groups_34981 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02223 (2/2) Thymidylate kinase
PF01503 (2/2) Phosphoribosyl-ATP pyrophosphohydrolase
precursor_groups_26486 153.43 +- 41.44 4 0 0 4 0.04 +- 0.03 4 10

TIGR03026 (4/4) nucleotide sugar dehydrogenase
TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF13537 (4/4) Glutamine amidotransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (4/4) Asparagine synthase
precursor_groups_15306 44.88 +- 0.65 2 0 0 0 0.07 +- 0.10 2 2

PF07690 (2/2) Major Facilitator Superfamily
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_54804 250.33 +- 103.89 2 0 0 0 0.14 +- 0.13 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00487 (1/2) Fatty acid desaturase
precursor_groups_51641 196.88 +- 46.88 2 0 2 0 0.02 +- 0.01 2 10

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF11639 (2/2) REDY-like protein HapK
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01839 (2/2) FG-GAP repeat
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_10229 631.51 +- 339.98 9 0 0 9 0.02 +- 0.01 9 12

TIGR01733 (9/9) amino acid adenylation domain
TIGR00702 (9/9) YcaO-type kinase domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07812 (9/9) TfuA-like protein
PF07690 (9/9) Major Facilitator Superfamily
PF05721 (9/9) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (9/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_37505 279.59 +- 240.41 2 0 0 2 0.05 +- 0.12 2 9

PF13360 (2/2) PQQ-like domain
PF06824 (2/2) Metal-independent alpha-mannosidase (GH125)
PF04203 (2/2) Sortase domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_groups_22906 159.06 +- 45.79 2 0 1 0 0.06 +- 0.08 2 8

PF12696 (2/2) TraM recognition site of TraD and TraG
PF03771 (2/2) Domain of unknown function (DUF317)
PF00772 (2/2) DnaB-like helicase N terminal domain
PF00145 (2/2) C-5 cytosine-specific DNA methylase
PF11203 (1/2) Putative type VII ESX secretion system translocon, EccE
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF00877 (1/2) NlpC/P60 family
PF00535 (1/2) Glycosyl transferase family 2
precursor_groups_22905 211.31 +- 42.70 3 0 0 0 0.01 +- 0.01 3 6

PF17963 (3/3) Bacterial Ig domain
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF09992 (3/3) Phosphodiester glycosidase
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF01066 (3/3) CDP-alcohol phosphatidyltransferase
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_638 240.63 +- 282.03 4 0 1 4 0.09 +- 0.21 4 7

TIGR04188 (4/4) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (4/4) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (4/4) putative ATP-grasp target RiPP
PF14408 (4/4) Ribosomally synthesised peptide in actinomycetes
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13581 (3/4) Histidine kinase-like ATPase domain
PF13560 (2/4) Helix-turn-helix domain
precursor_groups_639 208.09 +- 102.93 52 0 49 50 0.14 +- 0.11 52 12

TIGR03882 (50/52) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (50/52) thiazole/oxazole-forming peptide maturase, SagD family component
PF13191 (50/52) AAA ATPase domain
PF03704 (50/52) Bacterial transcriptional activator domain
PF02624 (50/52) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (50/52) Transcriptional regulatory protein, C terminal
TIGR03605 (49/52) SagB-type dehydrogenase domain
PF00881 (48/52) Nitroreductase family
PF14028 (47/52) Lantibiotic biosynthesis dehydratase C-term
PF04738 (47/52) Lantibiotic dehydratase, N terminus
PF00005 (47/52) ABC transporter
PF01061 (46/52) ABC-2 type transporter
precursor_groups_23457 75.50 +- 106.52 4 0 0 0 0.11 +- 0.19 4 2

PF02779 (4/4) Transketolase, pyrimidine binding domain
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
precursor_groups_70649 73.23 +- 56.77 2 0 0 0 0.07 +- 0.06 2 8

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13649 (1/2) Methyltransferase domain
PF12833 (1/2) Helix-turn-helix domain
PF12802 (1/2) MarR family
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07883 (1/2) Cupin domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_23453 63.44 +- 35.48 5 0 5 0 0.07 +- 0.05 5 8

PF14864 (5/5) Alkyl sulfatase C-terminal
PF14863 (5/5) Alkyl sulfatase dimerisation
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_36586 459.00 +- 99.71 3 0 1 3 0.01 +- 0.00 3 10

TIGR03822 (3/3) lysine-2,3-aminomutase-related protein
PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF12697 (3/3) Alpha/beta hydrolase family
PF12544 (3/3) Lysine-2,3-aminomutase
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF00144 (3/3) Beta-lactamase
precursor_groups_4442 88.55 +- 24.04 6 0 0 0 0.15 +- 0.09 6 4

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF07811 (6/6) TadE-like protein
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_groups_17238 195.55 +- 50.26 5 0 0 0 0.13 +- 0.18 5 11

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (5/5) virulence factor Mce family protein
PF16859 (5/5) Tetracyclin repressor-like, C-terminal domain
PF13406 (5/5) Transglycosylase SLT domain
PF11887 (5/5) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (5/5) Sigma-70, region 4
PF04542 (5/5) Sigma-70 region 2
PF02470 (5/5) MlaD protein
PF02405 (5/5) Permease MlaE
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter
precursor_groups_1165 22.51 +- 20.25 18 0 0 0 0.20 +- 0.37 18 7

PF13517 (18/18) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF07859 (18/18) alpha/beta hydrolase fold
PF07730 (18/18) Histidine kinase
PF01839 (18/18) FG-GAP repeat
PF00196 (18/18) Bacterial regulatory proteins, luxR family
PF00072 (18/18) Response regulator receiver domain
PF13460 (15/18) NAD(P)H-binding
precursor_groups_37298 517.33 +- 1.89 3 0 0 0 0.01 +- 0.00 3 6

PF09339 (3/3) IclR helix-turn-helix domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF02515 (3/3) CoA-transferase family III
PF01614 (3/3) Bacterial transcriptional regulator
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_49355 2405.00 +- 975.00 2 0 2 2 0.01 +- 0.00 2 9

TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13471 (2/2) Transglutaminase-like superfamily
PF13462 (2/2) Thioredoxin
PF07291 (2/2) Methylamine utilisation protein MauE
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (2/2) ABC-2 type transporter
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter
PF12730 (1/2) ABC-2 family transporter protein
precursor_groups_17237 39.16 +- 3.29 2 0 0 0 0.10 +- 0.07 2 5

TIGR01382 (2/2) intracellular protease, PfpI family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF03928 (2/2) Haem-degrading
PF01965 (2/2) DJ-1/PfpI family
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_61 87.35 +- 101.25 318 0 1 0 0.19 +- 0.31 318 11

PF00482 (315/318) Type II secretion system (T2SS), protein F
PF00437 (313/318) Type II/IV secretion system protein
PF07811 (312/318) TadE-like protein
PF00691 (306/318) OmpA family
TIGR03177 (301/318) Flp pilus assembly protein CpaB
PF16976 (301/318) Flp pilus assembly protein RcpC/CpaB
PF13400 (284/318) Putative Flp pilus-assembly TadE/G-like
PF13614 (274/318) AAA domain
PF00196 (251/318) Bacterial regulatory proteins, luxR family
PF00072 (251/318) Response regulator receiver domain
PF07730 (242/318) Histidine kinase
precursor_groups_61879 29.97 +- 0.36 2 0 0 0 0.23 +- 0.36 2 17

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
TIGR00655 (2/2) formyltetrahydrofolate deformylase
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13499 (2/2) EF-hand domain pair
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01435 (2/2) Peptidase family M48
PF01266 (2/2) FAD dependent oxidoreductase
PF00551 (2/2) Formyl transferase
PF00464 (2/2) Serine hydroxymethyltransferase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_11799 622.94 +- 221.83 6 0 5 6 0.01 +- 0.01 6 3

PF00733 (6/6) Asparagine synthase
PF13471 (5/6) Transglutaminase-like superfamily
PF00005 (5/6) ABC transporter
precursor_groups_45889 625.33 +- 170.24 3 0 2 0 0.02 +- 0.06 3 12

PF13649 (3/3) Methyltransferase domain
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF12850 (3/3) Calcineurin-like phosphoesterase superfamily domain
PF04389 (3/3) Peptidase family M28
PF01663 (3/3) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00334 (3/3) Nucleoside diphosphate kinase
PF00155 (3/3) Aminotransferase class I and II
TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
TIGR00040 (2/3) phosphodiesterase, MJ0936 family
PF13535 (2/3) ATP-grasp domain
PF13419 (2/3) Haloacid dehalogenase-like hydrolase
PF01116 (2/3) Fructose-bisphosphate aldolase class-II
precursor_groups_27511 197.79 +- 28.00 2 0 0 0 0.09 +- 0.23 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13621 (2/2) Cupin-like domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12704 (2/2) MacB-like periplasmic core domain
PF09334 (2/2) tRNA synthetases class I (M)
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02687 (2/2) FtsX-like permease family
PF01266 (2/2) FAD dependent oxidoreductase
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
precursor_groups_9557 112.04 +- 73.04 2 0 2 0 0.14 +- 0.26 2 20

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02127 (2/2) Aminopeptidase I zinc metalloprotease (M18)
PF01145 (2/2) SPFH domain / Band 7 family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (1/2) amino acid adenylation domain
PF12158 (1/2) Protein of unknown function (DUF3592)
PF00877 (1/2) NlpC/P60 family
precursor_groups_15413 291.00 +- 96.00 2 0 0 0 0.02 +- 0.01 2 12

PF02515 (2/2) CoA-transferase family III
TIGR01692 (1/2) 3-hydroxyisobutyrate dehydrogenase
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13602 (1/2) Zinc-binding dehydrogenase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/2) IclR helix-turn-helix domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF01614 (1/2) Bacterial transcriptional regulator
PF00561 (1/2) alpha/beta hydrolase fold
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00171 (1/2) Aldehyde dehydrogenase family
precursor_groups_51226 18.63 +- 2.64 2 0 0 0 0.16 +- 0.10 2 6

PF13247 (2/2) 4Fe-4S dicluster domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_41745 1167.00 +- 393.00 2 0 0 0 0.01 +- 0.00 2 4

PF17964 (2/2) Bacterial Ig domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF13304 (1/2) AAA domain, putative AbiEii toxin, Type IV TA system
precursor_groups_37341 181.12 +- 108.72 3 0 0 0 0.03 +- 0.05 3 3

PF14759 (3/3) Reductase C-terminal
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00067 (3/3) Cytochrome P450
precursor_groups_9823 404.91 +- 183.77 2 0 0 2 0.07 +- 0.11 2 18

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
TIGR01249 (1/2) prolyl aminopeptidase
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF04203 (1/2) Sortase domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01610 (1/2) Transposase
PF01381 (1/2) Helix-turn-helix
PF00672 (1/2) HAMP domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00561 (1/2) alpha/beta hydrolase fold
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00400 (1/2) WD domain, G-beta repeat
PF00072 (1/2) Response regulator receiver domain
precursor_groups_9822 390.00 +- 130.00 2 0 2 0 0.01 +- 0.00 2 3

TIGR01426 (2/2) glycosyltransferase, MGT family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00067 (2/2) Cytochrome P450
precursor_groups_9821 70.44 +- 14.79 3 0 3 0 0.15 +- 0.24 3 13

TIGR01733 (3/3) amino acid adenylation domain
TIGR01167 (3/3) LPXTG cell wall anchor domain
PF14012 (3/3) Protein of unknown function (DUF4229)
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00375 (3/3) Sodium:dicarboxylate symporter family
PF17932 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_33335 356.00 +- 31.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF17645 (2/2) Arylmalonate decarboxylase
PF07690 (2/2) Major Facilitator Superfamily
PF01361 (2/2) Tautomerase enzyme
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_36742 29.18 +- 7.68 2 0 0 0 0.07 +- 0.05 2 2

PF13649 (2/2) Methyltransferase domain
PF00484 (2/2) Carbonic anhydrase
precursor_groups_49229 211.91 +- 0.82 2 0 0 0 0.03 +- 0.03 2 3

PF08241 (2/2) Methyltransferase domain
PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
precursor_groups_80699 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
precursor_groups_4069 46.69 +- 34.46 4 0 0 0 0.11 +- 0.21 4 3

TIGR01249 (3/4) prolyl aminopeptidase
PF07470 (3/4) Glycosyl Hydrolase Family 88
PF00561 (3/4) alpha/beta hydrolase fold
precursor_groups_84864 116.24 +- 12.76 2 0 0 0 0.12 +- 0.18 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
PF13577 (1/2) SnoaL-like domain
precursor_groups_1061 75.74 +- 2.18 3 0 0 0 0.20 +- 0.16 3 20

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00377 (3/3) anti-anti-sigma factor
TIGR00229 (3/3) PAS domain S-box protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13466 (3/3) STAS domain
PF12697 (3/3) Alpha/beta hydrolase family
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00664 (3/3) ABC transporter transmembrane region
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
PF18029 (2/3) Glyoxalase-like domain
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_groups_1547 1192.21 +- 1345.69 29 8 21 28 0.02 +- 0.06 21 7

TIGR03882 (28/29) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (28/29) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (28/29) Lantibiotic biosynthesis dehydratase C-term
PF02624 (28/29) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (27/29) Nitroreductase family
PF04738 (25/29) Lantibiotic dehydratase, N terminus
TIGR03605 (24/29) SagB-type dehydrogenase domain
precursor_groups_4061 81.89 +- 12.27 5 0 5 0 0.21 +- 0.25 5 9

TIGR03797 (5/5) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (5/5) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (5/5) HlyD family secretion protein
PF03412 (5/5) Peptidase C39 family
PF00664 (5/5) ABC transporter transmembrane region
PF00027 (5/5) Cyclic nucleotide-binding domain
PF00005 (5/5) ABC transporter
PF01497 (3/5) Periplasmic binding protein
PF01032 (3/5) FecCD transport family
precursor_groups_1010 709.93 +- 630.25 2 0 0 0 0.03 +- 0.10 2 23

PF10145 (2/2) Phage-related minor tail protein
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR01725 (1/2) phage protein, HK97 gp10 family
TIGR01558 (1/2) putative phage terminase, small subunit, P27 family
PF16461 (1/2) Lambda phage tail tube protein, TTP
PF13411 (1/2) MerR HTH family regulatory protein
PF11651 (1/2) P22 coat protein - gene protein 5
PF11367 (1/2) Protein of unknown function (DUF3168)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF06199 (1/2) Phage tail tube protein
PF05908 (1/2) Poly-gamma-glutamate hydrolase
PF05521 (1/2) Phage head-tail joining protein
PF05133 (1/2) Phage portal protein, SPP1 Gp6-like
PF05119 (1/2) Phage terminase, small subunit
PF04860 (1/2) Phage portal protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF04586 (1/2) Caudovirus prohead serine protease
PF03237 (1/2) Terminase-like family
PF02018 (1/2) Carbohydrate binding domain
PF01391 (1/2) Collagen triple helix repeat (20 copies)
PF01381 (1/2) Helix-turn-helix
PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_1011 87.32 +- 78.46 6 0 0 0 0.12 +- 0.30 6 10

PF14016 (6/6) Protein of unknown function (DUF4232)
TIGR01840 (5/6) esterase, PHB depolymerase family
TIGR00666 (5/6) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF10503 (5/6) Esterase PHB depolymerase
PF02113 (5/6) D-Ala-D-Ala carboxypeptidase 3 (S13) family
TIGR00225 (3/6) C-terminal processing peptidase
TIGR00086 (3/6) SsrA-binding protein
PF17820 (3/6) PDZ domain
PF03572 (3/6) Peptidase family S41
PF01668 (3/6) SmpB protein
precursor_groups_5001 344.46 +- 274.74 2 0 0 0 0.03 +- 0.05 2 16

PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12831 (1/2) FAD dependent oxidoreductase
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07488 (1/2) Glycosyl hydrolase family 67 middle domain
PF07477 (1/2) Glycosyl hydrolase family 67 C-terminus
PF04616 (1/2) Glycosyl hydrolases family 43
PF03648 (1/2) Glycosyl hydrolase family 67 N-terminus
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02515 (1/2) CoA-transferase family III
PF01381 (1/2) Helix-turn-helix
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
precursor_groups_54803 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
precursor_groups_65848 114.26 +- 40.54 2 0 0 0 0.02 +- 0.02 2 3

PF06172 (2/2) Cupin superfamily (DUF985)
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF13564 (1/2) DoxX-like family
precursor_groups_15630 35.83 +- 1.34 4 0 0 0 0.20 +- 0.22 4 9

PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/4) Major Facilitator Superfamily
PF05544 (4/4) Proline racemase
PF04324 (4/4) BFD-like [2Fe-2S] binding domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01494 (4/4) FAD binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00701 (4/4) Dihydrodipicolinate synthetase family
precursor_groups_5006 67.21 +- 12.74 3 0 1 0 0.18 +- 0.29 3 8

PF05995 (3/3) Cysteine dioxygenase type I
PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF02018 (3/3) Carbohydrate binding domain
PF00704 (3/3) Glycosyl hydrolases family 18
PF00581 (3/3) Rhodanese-like domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF07883 (2/3) Cupin domain
precursor_groups_71689 344.00 +- 0.00 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_70 61.52 +- 43.85 4 0 2 0 0.15 +- 0.24 4 11

PF04226 (3/4) Transglycosylase associated protein
PF00005 (3/4) ABC transporter
TIGR01935 (2/4) RraA family
PF14378 (2/4) PAP2 superfamily
PF12222 (2/4) Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A
PF07730 (2/4) Histidine kinase
PF03737 (2/4) Aldolase/RraA
PF00494 (2/4) Squalene/phytoene synthase
PF00196 (2/4) Bacterial regulatory proteins, luxR family
PF00072 (2/4) Response regulator receiver domain
PF00069 (2/4) Protein kinase domain
precursor_groups_73 116.52 +- 145.94 9 0 1 0 0.15 +- 0.19 9

No common domains found
precursor_groups_1380 442.15 +- 378.48 10 0 4 10 0.03 +- 0.13 10 13

TIGR03969 (10/10) mycofactocin precursor
TIGR03967 (10/10) putative mycofactocin binding protein MftB
TIGR03965 (10/10) mycofactocin system glycosyltransferase
TIGR03964 (10/10) mycofactocin system creatininase family protein
TIGR03962 (10/10) mycofactocin radical SAM maturase
PF04055 (10/10) Radical SAM superfamily
PF02633 (10/10) Creatinine amidohydrolase
TIGR03966 (9/10) heme/flavin dehydrogenase, mycofactocin system
PF01070 (9/10) FMN-dependent dehydrogenase
PF13561 (8/10) Enoyl-(Acyl carrier protein) reductase
PF00535 (8/10) Glycosyl transferase family 2
TIGR04504 (7/10) SDR family mycofactocin-dependent oxidoreductase
PF13186 (7/10) Iron-sulfur cluster-binding domain
precursor_groups_67393 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 10

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_51354 180.98 +- 80.98 2 0 2 0 0.20 +- 0.32 2 29

PF12697 (2/2) Alpha/beta hydrolase family
PF03621 (2/2) MbtH-like protein
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02153 (2/2) Prephenate dehydrogenase
PF01070 (2/2) FMN-dependent dehydrogenase
PF00672 (2/2) HAMP domain
PF00664 (2/2) ABC transporter transmembrane region
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12704 (1/2) MacB-like periplasmic core domain
PF04820 (1/2) Tryptophan halogenase
PF02687 (1/2) FtsX-like permease family
PF01613 (1/2) Flavin reductase like domain
PF01471 (1/2) Putative peptidoglycan binding domain
PF00999 (1/2) Sodium/hydrogen exchanger family
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00067 (1/2) Cytochrome P450
precursor_groups_20437 128.15 +- 18.60 4 0 0 0 0.02 +- 0.01 4 3

PF07582 (4/4) AP endonuclease family 2 C terminus
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (4/4) Xylose isomerase-like TIM barrel
precursor_groups_1495 60.92 +- 21.76 12 0 0 0 0.21 +- 0.28 12 7

TIGR03860 (12/12) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (12/12) FAD-NAD(P)-binding
PF07920 (12/12) Protein of unknown function (DUF1684)
PF00296 (12/12) Luciferase-like monooxygenase
PF02983 (10/12) Alpha-lytic protease prodomain
PF01145 (10/12) SPFH domain / Band 7 family
PF00089 (10/12) Trypsin
precursor_groups_15811 622.59 +- 367.30 5 0 5 5 0.02 +- 0.01 5 8

TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM
PF14867 (5/5) Lantibiotic alpha
PF13575 (5/5) Domain of unknown function (DUF4135)
PF05147 (5/5) Lanthionine synthetase C-like protein
PF03412 (5/5) Peptidase C39 family
PF00664 (5/5) ABC transporter transmembrane region
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
precursor_groups_21431 116.98 +- 50.55 3 0 0 0 0.04 +- 0.05 3 3

PF07702 (3/3) UTRA domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_46998 721.16 +- 93.58 2 0 1 0 0.03 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF18130 (1/2) ATP-grasp N-terminal domain
PF00106 (1/2) short chain dehydrogenase
precursor_groups_20438 117.50 +- 102.35 3 0 0 0 0.16 +- 0.20 3 7

PF07690 (3/3) Major Facilitator Superfamily
PF04016 (3/3) Putative heavy-metal chelation
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00005 (3/3) ABC transporter
PF05175 (2/3) Methyltransferase small domain
precursor_groups_82277 68.66 +- 7.23 2 0 2 0 0.03 +- 0.03 2 5

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF05977 (2/2) Transmembrane secretion effector
PF00400 (2/2) WD domain, G-beta repeat
PF00106 (2/2) short chain dehydrogenase
precursor_groups_27464 422.58 +- 137.42 2 0 0 0 0.02 +- 0.01 2 7

TIGR02798 (2/2) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF03737 (2/2) Aldolase/RraA
PF02426 (2/2) Muconolactone delta-isomerase
PF02585 (1/2) GlcNAc-PI de-N-acetylase
precursor_groups_72305 193.05 +- 0.00 2 0 0 0 0.14 +- 0.11 2 9

PF17939 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13796 (2/2) Putative sensor
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07730 (2/2) Histidine kinase
PF01047 (2/2) MarR family
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_groups_72304 759.33 +- 76.39 2 0 0 0 0.01 +- 0.00 2 7

PF16375 (2/2) Domain of unknown function
PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF04616 (2/2) Glycosyl hydrolases family 43
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_7867 201.18 +- 102.88 3 0 0 0 0.08 +- 0.15 3 8

PF14759 (3/3) Reductase C-terminal
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
PF00067 (3/3) Cytochrome P450
precursor_groups_33424 97.17 +- 33.77 3 0 3 0 0.05 +- 0.06 3 10

TIGR01733 (3/3) amino acid adenylation domain
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF14681 (3/3) Uracil phosphoribosyltransferase
PF14027 (3/3) Questin oxidase-like
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF04227 (3/3) Indigoidine synthase A like protein
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_33423 18.20 +- 1.20 2 0 0 0 0.22 +- 0.34 2 8

PF13560 (2/2) Helix-turn-helix domain
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF04672 (2/2) S-adenosyl methyltransferase
PF04149 (2/2) Domain of unknown function (DUF397)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_14325 25.17 +- 3.50 2 0 0 0 0.12 +- 0.10 2 6

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF03606 (2/2) C4-dicarboxylate anaerobic carrier
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_groups_702 253.47 +- 72.14 3 0 1 0 0.03 +- 0.02 3

No common domains found
precursor_groups_13812 154.08 +- 30.42 6 0 2 0 0.03 +- 0.02 6 4

PF13377 (6/6) Periplasmic binding protein-like domain
PF05199 (6/6) GMC oxidoreductase
PF00732 (6/6) GMC oxidoreductase
PF00356 (6/6) Bacterial regulatory proteins, lacI family
precursor_groups_707 22.72 +- 16.71 5 0 0 0 0.17 +- 0.13 5 3

PF00296 (5/5) Luciferase-like monooxygenase
PF00497 (4/5) Bacterial extracellular solute-binding proteins, family 3
PF00583 (3/5) Acetyltransferase (GNAT) family
precursor_groups_76314 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_28640 260.28 +- 0.00 2 0 2 0 0.14 +- 0.17 2 19

TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF04673 (2/2) Polyketide synthesis cyclase
PF04672 (2/2) S-adenosyl methyltransferase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03358 (2/2) NADPH-dependent FMN reductase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_49647 963.66 +- 197.34 2 0 0 0 0.02 +- 0.01 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_63090 237.03 +- 98.37 2 0 0 0 0.02 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_5715 111.72 +- 55.63 2 0 2 0 0.19 +- 0.27 2 16

TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13761 (2/2) Domain of unknown function (DUF4166)
PF13692 (2/2) Glycosyl transferases group 1
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13439 (2/2) Glycosyltransferase Family 4
PF07719 (2/2) Tetratricopeptide repeat
PF04932 (2/2) O-Antigen ligase
PF03777 (2/2) ChpA-C
PF03023 (2/2) Lipid II flippase MurJ
PF02397 (2/2) Bacterial sugar transferase
PF01522 (2/2) Polysaccharide deacetylase
PF00857 (2/2) Isochorismatase family
PF00534 (2/2) Glycosyl transferases group 1
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00348 (2/2) Polyprenyl synthetase
PF17874 (1/2) MalT-like TPR region
precursor_groups_84062 48.84 +- 19.96 2 0 0 0 0.05 +- 0.08 2 4

PF13581 (2/2) Histidine kinase-like ATPase domain
PF04248 (2/2) Domain of unknown function (DUF427)
PF01323 (2/2) DSBA-like thioredoxin domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_41259 281.07 +- 8.65 2 0 2 0 0.08 +- 0.22 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF05977 (2/2) Transmembrane secretion effector
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00266 (1/2) Aminotransferase class-V
precursor_groups_9048 306.32 +- 181.72 10 0 0 0 0.02 +- 0.02 10 6

TIGR03930 (10/10) WXG100 family type VII secretion target
PF06013 (10/10) Proteins of 100 residues with WXG
TIGR03921 (9/10) type VII secretion-associated serine protease mycosin
PF05108 (9/10) Type VII secretion system ESX-1, transport TM domain B
PF00082 (9/10) Subtilase family
TIGR03919 (8/10) type VII secretion protein EccB
precursor_groups_80527 144.48 +- 113.52 2 0 0 0 0.04 +- 0.09 2 4

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF05977 (1/2) Transmembrane secretion effector
precursor_groups_2442 128.44 +- 86.71 8 0 0 0 0.04 +- 0.09 8 3

PF00583 (7/8) Acetyltransferase (GNAT) family
PF06441 (6/8) Epoxide hydrolase N terminus
PF00561 (6/8) alpha/beta hydrolase fold
precursor_groups_5207 16.84 +- 1.56 3 0 3 0 0.17 +- 0.21 3 9

PF13424 (3/3) Tetratricopeptide repeat
PF09997 (3/3) Predicted membrane protein (DUF2238)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF00348 (3/3) Polyprenyl synthetase
PF00144 (3/3) Beta-lactamase
PF00069 (3/3) Protein kinase domain
PF02342 (2/3) TerD domain
PF01987 (2/3) Mitochondrial biogenesis AIM24
PF00188 (2/3) Cysteine-rich secretory protein family
precursor_groups_33602 23.10 +- 1.60 2 0 0 0 0.13 +- 0.15 2 5

TIGR00127 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13581 (2/2) Histidine kinase-like ATPase domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00484 (2/2) Carbonic anhydrase
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
precursor_groups_14456 620.20 +- 241.60 4 0 1 0 0.01 +- 0.00 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00975 (4/4) Thioesterase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_61521 176.07 +- 58.26 2 0 0 0 0.15 +- 0.33 2 27

TIGR02868 (2/2) thiol reductant ABC exporter, CydC subunit
TIGR02857 (2/2) thiol reductant ABC exporter, CydD subunit
TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00458 (2/2) aspartate--tRNA(Asn) ligase
TIGR00203 (2/2) cytochrome d ubiquinol oxidase, subunit II
PF13499 (2/2) EF-hand domain pair
PF13185 (2/2) GAF domain
PF12849 (2/2) PBP superfamily domain
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07730 (2/2) Histidine kinase
PF05685 (2/2) Putative restriction endonuclease
PF04203 (2/2) Sortase domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02322 (2/2) Cytochrome bd terminal oxidase subunit II
PF01654 (2/2) Cytochrome bd terminal oxidase subunit I
PF01336 (2/2) OB-fold nucleic acid binding domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00672 (2/2) HAMP domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF07411 (1/2) Domain of unknown function (DUF1508)
precursor_groups_380 65.74 +- 21.10 4 0 1 0 0.16 +- 0.24 4 12

PF14013 (4/4) MT0933-like antitoxin protein
PF13377 (3/4) Periplasmic binding protein-like domain
PF00356 (3/4) Bacterial regulatory proteins, lacI family
TIGR00027 (2/4) methyltransferase, TIGR00027 family
PF14023 (2/4) Protein of unknown function (DUF4239)
PF13229 (2/4) Right handed beta helix region
PF04107 (2/4) Glutamate-cysteine ligase family 2(GCS2)
PF04072 (2/4) Leucine carboxyl methyltransferase
PF03422 (2/4) Carbohydrate binding module (family 6)
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00128 (2/4) Alpha amylase, catalytic domain
precursor_groups_21320 258.00 +- 129.00 2 0 2 2 0.02 +- 0.02 2 5

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00005 (2/2) ABC transporter
precursor_groups_2840 127.95 +- 47.84 22 0 0 3 0.19 +- 0.15 22 4

PF13400 (22/22) Putative Flp pilus-assembly TadE/G-like
PF07811 (22/22) TadE-like protein
PF00482 (22/22) Type II secretion system (T2SS), protein F
PF00437 (22/22) Type II/IV secretion system protein
precursor_groups_69916 83.87 +- 0.00 2 0 2 2 0.12 +- 0.29 2 18

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01177 (2/2) Asp/Glu/Hydantoin racemase
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_41415 106.95 +- 40.04 3 0 2 0 0.05 +- 0.08 3 8

PF12704 (3/3) MacB-like periplasmic core domain
PF02687 (3/3) FtsX-like permease family
PF02153 (3/3) Prephenate dehydrogenase
PF01471 (3/3) Putative peptidoglycan binding domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
TIGR03618 (2/3) PPOX class probable F420-dependent enzyme
PF01243 (2/3) Pyridoxamine 5'-phosphate oxidase
precursor_groups_2843 62.94 +- 13.05 28 0 0 0 0.15 +- 0.13 28 12

TIGR00247 (28/28) conserved hypothetical protein, YceG family
TIGR00026 (28/28) deazaflavin-dependent oxidoreductase, nitroreductase family
PF18029 (28/28) Glyoxalase-like domain
PF13411 (28/28) MerR HTH family regulatory protein
PF09278 (28/28) MerR, DNA binding
PF07729 (28/28) FCD domain
PF07690 (28/28) Major Facilitator Superfamily
PF04075 (28/28) F420H(2)-dependent quinone reductase
PF02618 (28/28) YceG-like family
PF00392 (27/28) Bacterial regulatory proteins, gntR family
TIGR01048 (25/28) diaminopimelate decarboxylase
PF02784 (25/28) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
precursor_groups_2844 31.19 +- 11.76 19 0 0 0 0.08 +- 0.10 19 5

PF17866 (19/19) AAA lid domain
PF13229 (19/19) Right handed beta helix region
PF00652 (19/19) Ricin-type beta-trefoil lectin domain
PF00082 (19/19) Subtilase family
PF00004 (19/19) ATPase family associated with various cellular activities (AAA)
precursor_groups_388 176.61 +- 167.39 2 0 1 0 0.13 +- 0.30 2 8

PF14016 (1/2) Protein of unknown function (DUF4232)
PF13424 (1/2) Tetratricopeptide repeat
PF05685 (1/2) Putative restriction endonuclease
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03704 (1/2) Bacterial transcriptional activator domain
PF03551 (1/2) Transcriptional regulator PadR-like family
PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18)
PF00931 (1/2) NB-ARC domain
precursor_groups_416 102.65 +- 84.16 5 0 0 0 0.11 +- 0.21 5 3

PF00436 (4/5) Single-strand binding protein family
PF12728 (3/5) Helix-turn-helix domain
PF10935 (3/5) Protein of unknown function (DUF2637)
precursor_groups_417 435.91 +- 84.09 2 0 0 0 0.01 +- 0.01 2 8

PF17996 (1/2) Carbohydrate esterase 2 N-terminal
PF17479 (1/2) Protein of unknown function (DUF3048) C-terminal domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF11258 (1/2) Protein of unknown function (DUF3048) N-terminal domain
PF10503 (1/2) Esterase PHB depolymerase
PF07859 (1/2) alpha/beta hydrolase fold
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
precursor_groups_142 61.10 +- 21.01 2 0 0 0 0.21 +- 0.33 2 14

TIGR03535 (2/2) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
PF17940 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14789 (2/2) Tetrahydrodipicolinate N-succinyltransferase middle
PF14602 (2/2) Hexapeptide repeat of succinyl-transferase
PF14019 (2/2) Protein of unknown function (DUF4235)
PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF18029 (1/2) Glyoxalase-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF00893 (1/2) Small Multidrug Resistance protein
precursor_groups_143 207.05 +- 385.83 9 0 0 1 0.15 +- 0.29 9 8

TIGR00042 (7/9) non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
PF07730 (7/9) Histidine kinase
PF01725 (7/9) Ham1 family
PF01061 (7/9) ABC-2 type transporter
PF00196 (7/9) Bacterial regulatory proteins, luxR family
PF00072 (7/9) Response regulator receiver domain
PF00005 (7/9) ABC transporter
PF02518 (6/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_147 103.89 +- 80.57 7 0 2 0 0.08 +- 0.08 7 1

PF00005 (5/7) ABC transporter
precursor_groups_57172 31.48 +- 1.93 2 0 0 0 0.13 +- 0.13 2 8

PF17128 (2/2) Domain of unknown function (DUF5107)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12840 (2/2) Helix-turn-helix domain
PF11706 (2/2) CGNR zinc finger
PF07336 (2/2) Putative stress-induced transcription regulator
PF05977 (2/2) Transmembrane secretion effector
PF13411 (1/2) MerR HTH family regulatory protein
PF07739 (1/2) TipAS antibiotic-recognition domain
precursor_groups_419 23.72 +- 19.01 13 0 1 0 0.14 +- 0.13 13 4

PF02133 (10/13) Permease for cytosine/purines, uracil, thiamine, allantoin
TIGR03668 (7/13) PPOX class probable F420-dependent enzyme, Rv0121 family
PF04199 (7/13) Putative cyclase
PF01243 (7/13) Pyridoxamine 5'-phosphate oxidase
precursor_groups_52571 6286.90 +- 4033.10 2 0 2 2 0.02 +- 0.07 2 21

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12698 (2/2) ABC-2 family transporter protein
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_63675 1545.24 +- 331.12 2 0 0 0 0.01 +- 0.00 2 9

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (2/2) Domain of unknown function (DUF4331)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00925 (2/2) GTP cyclohydrolase II
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_36962 24.37 +- 3.16 3 0 0 0 0.20 +- 0.11 3 3

TIGR00500 (3/3) methionine aminopeptidase, type I
PF02031 (3/3) Streptomyces extracellular neutral proteinase (M7) family
PF00557 (3/3) Metallopeptidase family M24
precursor_groups_76766 347.97 +- 44.64 2 0 2 0 0.03 +- 0.02 2 8

PF13377 (2/2) Periplasmic binding protein-like domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04978 (2/2) Protein of unknown function (DUF664)
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF17753 (1/2) Ig-fold domain
precursor_groups_84207 27.47 +- 8.39 2 0 0 0 0.16 +- 0.23 2 5

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12172 (2/2) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08445 (2/2) FR47-like protein
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF00005 (2/2) ABC transporter
precursor_groups_32642 345.45 +- 217.48 3 0 0 2 0.01 +- 0.01 3 7

PF12981 (3/3) Domain of Unknown Function with PDB structure (DUF3865)
PF08007 (3/3) Cupin superfamily protein
PF00487 (3/3) Fatty acid desaturase
PF04828 (2/3) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (2/3) Amidinotransferase
PF00999 (2/3) Sodium/hydrogen exchanger family
PF00881 (2/3) Nitroreductase family
precursor_groups_46375 12.06 +- 1.52 2 0 0 0 0.17 +- 0.21 2 2

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
precursor_groups_10155 195.08 +- 63.16 8 0 1 0 0.05 +- 0.07 8 13

PF17390 (8/8) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (8/8) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (8/8) Domain of unknown function (DUF4982)
PF14310 (8/8) Fibronectin type III-like domain
PF08531 (8/8) Alpha-L-rhamnosidase N-terminal domain
PF05592 (8/8) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (8/8) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (8/8) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (8/8) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (8/8) Glycosyl hydrolase family 3 N terminal domain
PF00703 (8/8) Glycosyl hydrolases family 2
PF18565 (7/8) Glycoside hydrolase family 2 C-terminal domain 5
PF07859 (6/8) alpha/beta hydrolase fold
precursor_groups_82907 46.22 +- 0.00 2 0 0 0 0.09 +- 0.10 2 6

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF05593 (2/2) RHS Repeat
PF02627 (2/2) Carboxymuconolactone decarboxylase family
precursor_groups_57199 451.50 +- 64.50 2 0 2 0 0.01 +- 0.00 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
precursor_groups_39610 75.58 +- 11.08 2 0 0 0 0.03 +- 0.02 2 7

TIGR00348 (2/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF11867 (2/2) Domain of unknown function (DUF3387)
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_groups_563 240.50 +- 137.80 37 2 35 37 0.05 +- 0.08 35 4

PF05147 (37/37) Lanthionine synthetase C-like protein
PF01061 (37/37) ABC-2 type transporter
PF00069 (37/37) Protein kinase domain
PF00005 (37/37) ABC transporter
precursor_groups_566 415.03 +- 427.70 6 0 0 0 0.03 +- 0.05 6 12

TIGR01509 (5/6) HAD hydrolase, family IA, variant 3
TIGR00879 (5/6) MFS transporter, sugar porter (SP) family
PF13561 (5/6) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/6) Haloacid dehalogenase-like hydrolase
PF05199 (5/6) GMC oxidoreductase
PF02894 (5/6) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/6) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/6) GMC oxidoreductase
PF00682 (5/6) HMGL-like
PF00293 (5/6) NUDIX domain
PF00083 (5/6) Sugar (and other) transporter
PF01761 (4/6) 3-dehydroquinate synthase
precursor_groups_565 145.48 +- 70.77 4 0 0 0 0.13 +- 0.17 4 9

PF07730 (3/4) Histidine kinase
PF17939 (2/4) Tetracyclin repressor-like, C-terminal domain
PF13796 (2/4) Putative sensor
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/4) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF01047 (2/4) MarR family
PF00440 (2/4) Bacterial regulatory proteins, tetR family
PF00067 (2/4) Cytochrome P450
precursor_groups_568 255.40 +- 218.10 18 0 13 8 0.12 +- 0.16 18 12

TIGR01525 (17/18) heavy metal translocating P-type ATPase
PF04314 (17/18) Copper chaperone PCu(A)C
PF00702 (17/18) haloacid dehalogenase-like hydrolase
PF00403 (17/18) Heavy-metal-associated domain
PF00122 (17/18) E1-E2 ATPase
PF01497 (16/18) Periplasmic binding protein
PF01032 (16/18) FecCD transport family
PF00005 (16/18) ABC transporter
PF07690 (13/18) Major Facilitator Superfamily
TIGR02937 (9/18) RNA polymerase sigma factor, sigma-70 family
PF08281 (9/18) Sigma-70, region 4
PF04542 (9/18) Sigma-70 region 2
precursor_groups_569 204.35 +- 150.46 6 0 3 1 0.04 +- 0.07 6

No common domains found
precursor_groups_24085 125.56 +- 76.73 4 0 0 0 0.02 +- 0.01 4 4

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain
precursor_groups_93 97.30 +- 123.93 27 0 5 3 0.13 +- 0.16 27

No common domains found
precursor_groups_91 231.58 +- 247.04 6 0 2 0 0.12 +- 0.28 6 3

PF09490 (6/6) Probable cobalt transporter subunit (CbtA)
PF09489 (6/6) Probable cobalt transporter subunit (CbtB)
PF00403 (3/6) Heavy-metal-associated domain
precursor_groups_2227 369.40 +- 218.56 5 0 2 0 0.07 +- 0.18 5 13

TIGR02348 (3/5) chaperonin GroL
TIGR01197 (3/5) metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
PF04909 (3/5) Amidohydrolase
PF02406 (3/5) MmoB/DmpM family
PF02332 (3/5) Methane/Phenol/Toluene Hydroxylase
PF01883 (3/5) Iron-sulfur cluster assembly protein
PF01566 (3/5) Natural resistance-associated macrophage protein
PF00970 (3/5) Oxidoreductase FAD-binding domain
PF00175 (3/5) Oxidoreductase NAD-binding domain
PF00118 (3/5) TCP-1/cpn60 chaperonin family
PF00111 (3/5) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (3/5) Zinc-binding dehydrogenase
precursor_groups_97 375.68 +- 60.19 3 0 3 0 0.18 +- 0.28 3 29

PF01494 (3/3) FAD binding domain
TIGR02246 (2/3) conserved hypothetical protein
TIGR01207 (2/3) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/3) dTDP-glucose 4,6-dehydratase
PF16363 (2/3) GDP-mannose 4,6 dehydratase
PF13649 (2/3) Methyltransferase domain
PF12051 (2/3) Protein of unknown function (DUF3533)
PF10604 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/3) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/3) Histidine kinase
PF04673 (2/3) Polyketide synthesis cyclase
PF03559 (2/3) NDP-hexose 2,3-dehydratase
PF03364 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF01370 (2/3) NAD dependent epimerase/dehydratase family
PF01041 (2/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/3) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/3) Acyl transferase domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00483 (2/3) Nucleotidyl transferase
PF00248 (2/3) Aldo/keto reductase family
PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/3) short chain dehydrogenase
PF00072 (2/3) Response regulator receiver domain
precursor_groups_96 381.88 +- 789.77 10 0 0 0 0.11 +- 0.25 10 2

PF04149 (10/10) Domain of unknown function (DUF397)
PF13560 (6/10) Helix-turn-helix domain
precursor_groups_79324 80.93 +- 54.86 2 0 2 0 0.09 +- 0.07 2 9

TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01546 (2/2) Peptidase family M20/M25/M40
PF01522 (2/2) Polysaccharide deacetylase
precursor_groups_32792 297.50 +- 79.66 3 0 3 0 0.01 +- 0.01 3 5

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_groups_56824 184.29 +- 73.71 2 0 0 0 0.01 +- 0.01 2 3

TIGR03168 (2/2) hexose kinase, 1-phosphofructokinase family
PF11964 (2/2) SpoIIAA-like
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_98 154.51 +- 150.89 9 0 3 1 0.11 +- 0.19 9 1

PF05532 (8/9) CsbD-like
precursor_groups_35913 78.71 +- 73.04 3 0 0 0 0.11 +- 0.28 3 7

PF13462 (3/3) Thioredoxin
PF11292 (3/3) Protein of unknown function (DUF3093)
PF09678 (3/3) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF07987 (3/3) Domain of unkown function (DUF1775)
PF05425 (3/3) Copper resistance protein D
PF04234 (3/3) CopC domain
PF00484 (3/3) Carbonic anhydrase
precursor_groups_36816 29.96 +- 2.80 2 0 0 0 0.13 +- 0.06 2 4

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF07045 (2/2) Domain of unknown function (DUF1330)
PF01047 (2/2) MarR family
precursor_groups_81126 206.87 +- 19.67 2 0 2 0 0.12 +- 0.25 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12840 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF09056 (2/2) Prokaryotic phospholipase A2
PF03704 (2/2) Bacterial transcriptional activator domain
PF03621 (2/2) MbtH-like protein
PF01804 (2/2) Penicillin amidase
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00067 (2/2) Cytochrome P450
precursor_groups_30428 302.19 +- 237.69 4 0 0 0 0.06 +- 0.11 4 18

TIGR01088 (4/4) 3-dehydroquinate dehydratase, type II
PF18317 (4/4) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (4/4) IclR helix-turn-helix domain
PF08501 (4/4) Shikimate dehydrogenase substrate binding domain
PF07836 (4/4) DmpG-like communication domain
PF07690 (4/4) Major Facilitator Superfamily
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01614 (4/4) Bacterial transcriptional regulator
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF01220 (4/4) Dehydroquinase class II
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (4/4) HMGL-like
PF00083 (4/4) Sugar (and other) transporter
TIGR03217 (3/4) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (3/4) acetaldehyde dehydrogenase (acetylating)
PF09290 (3/4) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (3/4) Semialdehyde dehydrogenase, NAD binding domain
precursor_groups_52586 38.06 +- 0.32 2 0 0 0 0.11 +- 0.26 2 13

TIGR02170 (2/2) thymidylate synthase, flavin-dependent
TIGR00730 (2/2) TIGR00730 family protein
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02655 (2/2) ATP-grasp domain
PF02511 (2/2) Thymidylate synthase complementing protein
PF00860 (2/2) Permease family
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_39721 1676.81 +- 761.48 3 0 0 0 0.01 +- 0.01 3 4

PF07811 (3/3) TadE-like protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_groups_2710 64.47 +- 15.74 3 0 3 0 0.03 +- 0.02 3 1

PF01494 (3/3) FAD binding domain
precursor_groups_4295 158.65 +- 104.82 18 0 0 0 0.02 +- 0.01 18 5

PF14200 (18/18) Ricin-type beta-trefoil lectin domain-like
PF05270 (18/18) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03752 (18/18) Short repeats of unknown function
PF00720 (18/18) Subtilisin inhibitor-like
PF00652 (18/18) Ricin-type beta-trefoil lectin domain
precursor_groups_2713 26.25 +- 9.73 27 0 4 0 0.15 +- 0.05 27 4

TIGR01691 (27/27) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (27/27) ARD/ARD' family
PF00596 (27/27) Class II Aldolase and Adducin N-terminal domain
TIGR03328 (25/27) methylthioribulose-1-phosphate dehydratase
precursor_groups_47627 56.00 +- 0.39 2 0 2 0 0.14 +- 0.14 2 16

TIGR02353 (2/2) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (2/2) amino acid adenylation domain
TIGR01350 (2/2) dihydrolipoyl dehydrogenase
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13578 (2/2) Methyltransferase domain
PF13520 (2/2) Amino acid permease
PF10009 (2/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF09557 (2/2) Domain of unknown function (DUF2382)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05239 (2/2) PRC-barrel domain
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01433 (2/2) Peptidase family M1 domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF04239 (1/2) Protein of unknown function (DUF421)
precursor_groups_13105 245.38 +- 147.97 7 0 0 0 0.02 +- 0.01 7 4

PF03737 (7/7) Aldolase/RraA
PF00994 (7/7) Probable molybdopterin binding domain
PF00682 (7/7) HMGL-like
PF00180 (7/7) Isocitrate/isopropylmalate dehydrogenase
precursor_groups_85901 38.07 +- 21.47 2 0 0 0 0.08 +- 0.08 2 2

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_13100 195.27 +- 37.88 5 0 5 0 0.04 +- 0.07 5 4

PF11468 (5/5) Aromatic prenyltransferase Orf2
PF04672 (5/5) S-adenosyl methyltransferase
PF03284 (5/5) Phenazine biosynthesis protein A/B
PF01494 (5/5) FAD binding domain
precursor_groups_70131 208.94 +- 79.94 2 0 2 0 0.02 +- 0.04 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF14518 (2/2) Iron-containing redox enzyme
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF04820 (2/2) Tryptophan halogenase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_4292 299.15 +- 261.61 18 2 16 0 0.03 +- 0.09 16 4

PF12697 (18/18) Alpha/beta hydrolase family
PF02441 (18/18) Flavoprotein
PF13649 (17/18) Methyltransferase domain
PF00005 (17/18) ABC transporter
precursor_groups_53219 1290.00 +- 387.00 2 0 2 0 0.01 +- 0.02 2 20

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_72365 84.34 +- 41.52 2 0 2 0 0.16 +- 0.24 2 11

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF03621 (2/2) MbtH-like protein
PF01032 (2/2) FecCD transport family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_38741 535.94 +- 223.49 3 0 0 0 0.01 +- 0.01 3 13

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03925 (3/3) type VII secretion protein EccCb
TIGR03924 (3/3) type VII secretion protein EccCa
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF17866 (3/3) AAA lid domain
PF13229 (3/3) Right handed beta helix region
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
PF01580 (3/3) FtsK/SpoIIIE family
PF00004 (3/3) ATPase family associated with various cellular activities (AAA)
precursor_groups_79036 250.33 +- 103.89 2 0 0 0 0.14 +- 0.13 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00487 (1/2) Fatty acid desaturase
precursor_groups_58573 2340.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 11

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_17254 41.54 +- 12.88 2 0 0 0 0.08 +- 0.09 2 5

PF12833 (2/2) Helix-turn-helix domain
PF05685 (2/2) Putative restriction endonuclease
PF02311 (2/2) AraC-like ligand binding domain
PF00892 (2/2) EamA-like transporter family
PF00069 (2/2) Protein kinase domain
precursor_groups_2382 80.32 +- 35.78 2 0 0 0 0.14 +- 0.11 2 4

PF13649 (2/2) Methyltransferase domain
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00872 (1/2) Transposase, Mutator family
precursor_groups_55931 346.98 +- 73.88 2 0 0 0 0.14 +- 0.19 2 21

PF18130 (2/2) ATP-grasp N-terminal domain
PF17196 (2/2) Protein of unknown function (DUF5133)
PF14759 (2/2) Reductase C-terminal
PF13535 (2/2) ATP-grasp domain
PF13244 (2/2) Domain of unknown function (DUF4040)
PF09364 (2/2) XFP N-terminal domain
PF09363 (2/2) XFP C-terminal domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF04183 (2/2) IucA / IucC family
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF03894 (2/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00005 (2/2) ABC transporter
PF04039 (1/2) Domain related to MnhB subunit of Na+/H+ antiporter
precursor_groups_24883 103.71 +- 34.27 4 0 4 0 0.06 +- 0.07 4 14

PF13560 (4/4) Helix-turn-helix domain
PF13367 (4/4) PrsW family intramembrane metalloprotease
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00756 (4/4) Putative esterase
TIGR02965 (2/4) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/4) xanthine dehydrogenase accessory protein XdhC
PF13478 (2/4) XdhC Rossmann domain
PF03450 (2/4) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/4) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/4) XdhC and CoxI family
PF01799 (2/4) [2Fe-2S] binding domain
PF01315 (2/4) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/4) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_24882 171.19 +- 56.94 4 0 0 0 0.01 +- 0.01 4 4

TIGR00447 (4/4) aminoacyl-tRNA hydrolase
PF11303 (4/4) Protein of unknown function (DUF3105)
PF03713 (4/4) Domain of unknown function (DUF305)
PF01195 (4/4) Peptidyl-tRNA hydrolase
precursor_groups_52615 1946.06 +- 324.34 2 0 2 0 0.01 +- 0.01 2 19

TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01206 (2/2) lysine biosynthesis protein LysW
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (2/2) RimK-like ATP-grasp domain
PF03936 (2/2) Terpene synthase family, metal binding domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00348 (2/2) Polyprenyl synthetase
PF00067 (2/2) Cytochrome P450
precursor_groups_10974 13.59 +- 8.92 5 0 0 0 0.21 +- 0.21 5 6

TIGR01488 (5/5) HAD phosphoserine phosphatase-like hydrolase, family IB
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF01243 (5/5) Pyridoxamine 5'-phosphate oxidase
PF00970 (5/5) Oxidoreductase FAD-binding domain
PF00175 (5/5) Oxidoreductase NAD-binding domain
PF00042 (5/5) Globin
precursor_groups_76803 585.00 +- 195.00 2 0 0 2 0.01 +- 0.01 2 7

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
precursor_groups_31111 34.55 +- 4.24 4 0 0 0 0.09 +- 0.03 4 7

PF13377 (4/4) Periplasmic binding protein-like domain
PF13343 (4/4) Bacterial extracellular solute-binding protein
PF12802 (4/4) MarR family
PF12680 (4/4) SnoaL-like domain
PF01323 (4/4) DSBA-like thioredoxin domain
PF00753 (4/4) Metallo-beta-lactamase superfamily
PF00356 (4/4) Bacterial regulatory proteins, lacI family
precursor_groups_31117 473.18 +- 329.18 3 0 3 0 0.08 +- 0.18 3 18

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03704 (3/3) Bacterial transcriptional activator domain
PF03466 (3/3) LysR substrate binding domain
PF03176 (3/3) MMPL family
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01323 (3/3) DSBA-like thioredoxin domain
PF01061 (3/3) ABC-2 type transporter
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
precursor_groups_68064 323.00 +- 193.00 2 0 0 0 0.05 +- 0.07 2 5

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (2/2) MDMPI C-terminal domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04672 (1/2) S-adenosyl methyltransferase
precursor_groups_85550 169.53 +- 20.58 2 0 0 2 0.08 +- 0.14 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05726 (2/2) Pirin C-terminal cupin domain
PF04055 (2/2) Radical SAM superfamily
PF02678 (2/2) Pirin
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_36304 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_19562 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat
precursor_groups_12078 139.96 +- 73.90 8 0 0 0 0.08 +- 0.09 8 7

PF07729 (8/8) FCD domain
PF01670 (8/8) Glycosyl hydrolase family 12
PF01081 (8/8) KDPG and KHG aldolase
PF00553 (8/8) Cellulose binding domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
PF00144 (8/8) Beta-lactamase
precursor_groups_70002 226.79 +- 6.54 2 0 0 0 0.04 +- 0.02 2 12

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13377 (2/2) Periplasmic binding protein-like domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF07282 (2/2) Putative transposase DNA-binding domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_27995 79.71 +- 24.12 3 0 0 0 0.14 +- 0.07 3 7

PF13378 (3/3) Enolase C-terminal domain-like
PF04203 (3/3) Sortase domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF14344 (2/3) Domain of unknown function (DUF4397)
precursor_groups_40929 472.76 +- 304.53 3 0 2 0 0.01 +- 0.01 3 8

PF00501 (3/3) AMP-binding enzyme
PF00221 (3/3) Aromatic amino acid lyase
PF08031 (2/3) Berberine and berberine like
PF06236 (2/3) Tyrosinase co-factor MelC1
PF03704 (2/3) Bacterial transcriptional activator domain
PF01565 (2/3) FAD binding domain
PF00486 (2/3) Transcriptional regulatory protein, C terminal
PF00264 (2/3) Common central domain of tyrosinase
precursor_groups_53520 169.21 +- 53.65 2 0 0 0 0.04 +- 0.06 2 9

TIGR00481 (2/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF01161 (2/2) Phosphatidylethanolamine-binding protein
PF01042 (2/2) Endoribonuclease L-PSP
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_13985 35.63 +- 10.70 6 0 0 0 0.19 +- 0.20 6 13

PF13517 (6/6) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (6/6) Acetyltransferase (GNAT) domain
PF07690 (6/6) Major Facilitator Superfamily
PF00089 (6/6) Trypsin
TIGR00045 (5/6) glycerate kinase
PF12867 (5/6) DinB superfamily
PF02595 (5/6) Glycerate kinase family
PF02518 (5/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (5/6) Sodium:sulfate symporter transmembrane region
PF00672 (5/6) HAMP domain
PF00512 (5/6) His Kinase A (phospho-acceptor) domain
PF00486 (5/6) Transcriptional regulatory protein, C terminal
PF00072 (5/6) Response regulator receiver domain
precursor_groups_72932 88.24 +- 7.83 2 0 2 0 0.11 +- 0.16 2 17

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17829 (2/2) Gylcosyl hydrolase family 115 C-terminal domain
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF15979 (2/2) Glycosyl hydrolase family 115
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08962 (2/2) Domain of unknown function (DUF1876)
PF07971 (2/2) Glycosyl hydrolase family 92
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00583 (2/2) Acetyltransferase (GNAT) family
PF14310 (1/2) Fibronectin type III-like domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_82872 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF15607 (2/2) Bacterial toxin 44
PF12256 (2/2) Insecticide toxin TcdB middle/N-terminal region
PF05593 (2/2) RHS Repeat
PF03534 (2/2) Salmonella virulence plasmid 65kDa B protein
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_18346 39.43 +- 9.11 5 0 0 0 0.08 +- 0.10 5 6

TIGR02983 (5/5) RNA polymerase sigma-70 factor, sigma-E family
PF13489 (5/5) Methyltransferase domain
PF08281 (5/5) Sigma-70, region 4
PF04978 (5/5) Protein of unknown function (DUF664)
PF04542 (5/5) Sigma-70 region 2
PF13424 (3/5) Tetratricopeptide repeat
precursor_groups_18349 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_groups_25599 712.24 +- 556.22 4 0 4 0 0.06 +- 0.18 4 11

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10604 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_38413 43.53 +- 3.38 2 0 0 0 0.18 +- 0.09 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_57118 142.58 +- 0.76 2 0 2 2 0.01 +- 0.01 2 3

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase
PF00293 (2/2) NUDIX domain
precursor_groups_35735 555.81 +- 476.19 2 0 0 0 0.05 +- 0.13 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_38521 75.95 +- 28.25 3 0 0 0 0.03 +- 0.03 3 2

PF08241 (3/3) Methyltransferase domain
PF00334 (3/3) Nucleoside diphosphate kinase
precursor_groups_24426 428.74 +- 208.93 4 0 0 0 0.02 +- 0.02 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02615 (4/4) Malate/L-lactate dehydrogenase
PF00753 (4/4) Metallo-beta-lactamase superfamily
precursor_groups_41302 225.63 +- 112.37 2 0 0 0 0.07 +- 0.11 2 19

PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR03668 (1/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (1/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (1/2) Fibronectin type III-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (1/2) Peptidase_C39 like family
PF04545 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04539 (1/2) Sigma-70 region 3
PF03547 (1/2) Membrane transport protein
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_groups_53458 23.30 +- 0.70 2 0 0 0 0.13 +- 0.15 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_groups_25793 978.98 +- 403.99 3 0 2 2 0.01 +- 0.00 3 9

PF07690 (3/3) Major Facilitator Superfamily
PF00805 (3/3) Pentapeptide repeats (8 copies)
TIGR03975 (2/3) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/3) Methyltransferase domain
PF05193 (2/3) Peptidase M16 inactive domain
PF04989 (2/3) Cephalosporin hydroxylase
PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
PF00675 (2/3) Insulinase (Peptidase family M16)
precursor_groups_17790 1168.00 +- 652.00 2 0 0 0 0.01 +- 0.01 2 10

TIGR04377 (2/2) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_17824 69.33 +- 46.77 2 0 0 0 0.15 +- 0.18 2 9

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
PF02803 (1/2) Thiolase, C-terminal domain
PF01925 (1/2) Sulfite exporter TauE/SafE
PF00108 (1/2) Thiolase, N-terminal domain
precursor_groups_25444 21.60 +- 13.06 2 0 0 0 0.16 +- 0.30 2 5

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_22312 16.52 +- 1.04 2 0 0 0 0.18 +- 0.34 2 6

TIGR04037 (2/2) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (2/2) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF03358 (2/2) NADPH-dependent FMN reductase
PF00582 (2/2) Universal stress protein family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_19150 69.21 +- 24.69 2 0 0 0 0.22 +- 0.39 2 21

TIGR01317 (1/2) glutamate synthase, NADH/NADPH, small subunit
PF14691 (1/2) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF14568 (1/2) SMI1-KNR4 cell-wall
PF13462 (1/2) Thioredoxin
PF13432 (1/2) Tetratricopeptide repeat
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF09348 (1/2) Domain of unknown function (DUF1990)
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF04898 (1/2) Glutamate synthase central domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01645 (1/2) Conserved region in glutamate synthase
PF01493 (1/2) GXGXG motif
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00664 (1/2) ABC transporter transmembrane region
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00459 (1/2) Inositol monophosphatase family
PF00310 (1/2) Glutamine amidotransferases class-II
PF00005 (1/2) ABC transporter
precursor_groups_19253 61.31 +- 24.17 2 0 0 0 0.11 +- 0.07 2 9

TIGR01217 (2/2) acetoacetate-CoA ligase
PF16177 (2/2) Acetyl-coenzyme A synthetase N-terminus
PF13564 (2/2) DoxX-like family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (2/2) AMP-binding enzyme
PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_groups_9479 88.12 +- 48.67 7 0 7 0 0.06 +- 0.03 7 11

TIGR02814 (7/7) PfaD family protein
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF14765 (7/7) Polyketide synthase dehydratase
PF08659 (7/7) KR domain
PF07993 (7/7) Male sterility protein
PF07977 (7/7) FabA-like domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF00753 (7/7) Metallo-beta-lactamase superfamily
PF00698 (7/7) Acyl transferase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_19363 251.78 +- 56.26 3 0 1 0 0.15 +- 0.24 3 11

PF11975 (3/3) Family 4 glycosyl hydrolase C-terminal domain
PF08376 (3/3) Nitrate and nitrite sensing
PF07690 (3/3) Major Facilitator Superfamily
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02056 (3/3) Family 4 glycosyl hydrolase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
PF03537 (2/3) Glycoside-hydrolase family GH114
precursor_groups_18767 165.86 +- 0.00 2 0 2 0 0.02 +- 0.02 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13601 (2/2) Winged helix DNA-binding domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03403 (2/2) Platelet-activating factor acetylhydrolase, isoform II
PF00501 (2/2) AMP-binding enzyme
precursor_groups_18766 486.41 +- 428.32 2 0 0 0 0.08 +- 0.22 2 16

TIGR01766 (2/2) transposase, IS605 OrfB family
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12730 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF02698 (2/2) DUF218 domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF05630 (1/2) Necrosis inducing protein (NPP1)
PF02057 (1/2) Glycosyl hydrolase family 59
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
precursor_groups_78586 464.19 +- 100.19 2 0 0 0 0.02 +- 0.02 2 10

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF02449 (2/2) Beta-galactosidase
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_66946 12.71 +- 0.98 2 0 0 0 0.16 +- 0.01 2 2

PF08241 (2/2) Methyltransferase domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_3158 21.32 +- 7.84 9 0 0 0 0.16 +- 0.22 9 5

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF11361 (9/9) Protein of unknown function (DUF3159)
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (9/9) Polysaccharide deacetylase
PF08530 (7/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
precursor_groups_6384 433.15 +- 43.15 2 0 2 0 0.02 +- 0.02 2 18

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14435 (2/2) SUKH-4 immunity protein
PF13462 (2/2) Thioredoxin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_19676 19.26 +- 0.00 2 0 0 0 0.10 +- 0.09 2 5

TIGR01085 (2/2) UDP-N-acetylmuramyl-tripeptide synthetase
PF08245 (2/2) Mur ligase middle domain
PF02875 (2/2) Mur ligase family, glutamate ligase domain
PF01225 (2/2) Mur ligase family, catalytic domain
PF00135 (2/2) Carboxylesterase family
precursor_groups_6926 68.17 +- 23.60 2 0 0 2 0.05 +- 0.02 2 7

TIGR04188 (2/2) methyltransferase, ATP-grasp peptide maturase system
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
TIGR04187 (1/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (1/2) putative ATP-grasp target RiPP
PF14408 (1/2) Ribosomally synthesised peptide in actinomycetes
PF13649 (1/2) Methyltransferase domain
PF08241 (1/2) Methyltransferase domain
precursor_groups_3156 386.59 +- 363.71 17 0 0 0 0.05 +- 0.08 17 15

PF18565 (17/17) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (17/17) Domain of unknown function (DUF4982)
PF14310 (17/17) Fibronectin type III-like domain
PF07859 (17/17) alpha/beta hydrolase fold
PF02837 (17/17) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (17/17) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (17/17) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (17/17) Glycosyl hydrolase family 3 N terminal domain
PF00703 (17/17) Glycosyl hydrolases family 2
PF17390 (16/17) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (16/17) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (16/17) Alpha-L-rhamnosidase N-terminal domain
PF05592 (16/17) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00135 (14/17) Carboxylesterase family
PF00106 (13/17) short chain dehydrogenase
precursor_groups_28751 217.71 +- 75.43 4 0 0 4 0.07 +- 0.14 4 6

PF04828 (4/4) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (4/4) Amidinotransferase
PF00999 (4/4) Sodium/hydrogen exchanger family
PF00881 (4/4) Nitroreductase family
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/4) Major Facilitator Superfamily
precursor_groups_55026 976.89 +- 399.11 2 0 2 0 0.02 +- 0.01 2 13

TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (2/2) Amino acid kinase family
PF00682 (2/2) HMGL-like
PF00501 (2/2) AMP-binding enzyme
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_groups_6726 27.62 +- 17.66 6 0 2 0 0.19 +- 0.17 6 21

TIGR00143 (6/6) carbamoyltransferase HypF
TIGR00073 (6/6) hydrogenase accessory protein HypB
TIGR00072 (6/6) hydrogenase maturation protease
PF17788 (6/6) HypF Kae1-like domain
PF14720 (6/6) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (6/6) Protein of unknown function (DUF4232)
PF07503 (6/6) HypF finger
PF02492 (6/6) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (6/6) Hydrogenase maturation protease
PF01300 (6/6) Telomere recombination
PF01155 (6/6) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (6/6) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (6/6) Acylphosphatase
PF00374 (6/6) Nickel-dependent hydrogenase
TIGR02124 (5/6) hydrogenase expression/formation protein HypE
TIGR00075 (5/6) hydrogenase expression/formation protein HypD
TIGR00074 (5/6) hydrogenase assembly chaperone HypC/HupF
PF02769 (5/6) AIR synthase related protein, C-terminal domain
PF01924 (5/6) Hydrogenase formation hypA family
PF01455 (5/6) HupF/HypC family
PF00586 (5/6) AIR synthase related protein, N-terminal domain
precursor_groups_20405 235.76 +- 54.49 2 0 0 0 0.08 +- 0.12 2 11

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (2/2) Domain of unknown function (DUF4331)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00925 (2/2) GTP cyclohydrolase II
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00082 (2/2) Subtilase family
precursor_groups_17957 25.47 +- 0.05 2 0 0 0 0.24 +- 0.13 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13426 (2/2) PAS domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04616 (2/2) Glycosyl hydrolases family 43
PF01095 (2/2) Pectinesterase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00067 (2/2) Cytochrome P450
precursor_groups_17074 42.25 +- 29.71 3 0 1 0 0.10 +- 0.14 3 4

PF00480 (3/3) ROK family
PF00027 (3/3) Cyclic nucleotide-binding domain
PF09992 (2/3) Phosphodiester glycosidase
PF01510 (2/3) N-acetylmuramoyl-L-alanine amidase
precursor_groups_20404 35.47 +- 3.22 2 0 0 0 0.14 +- 0.05 2 7

PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_55594 68.31 +- 1.00 2 0 0 0 0.09 +- 0.20 2 13

TIGR03885 (2/2) probable non-F420 flavinoid oxidoreductase
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16657 (2/2) Maltogenic Amylase, C-terminal domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF13384 (2/2) Homeodomain-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF05231 (2/2) MASE1
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF00296 (2/2) Luciferase-like monooxygenase
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_22001 151.71 +- 129.74 2 0 2 0 0.10 +- 0.14 2 7

TIGR04316 (2/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01474 (2/2) Class-II DAHP synthetase family
PF00857 (2/2) Isochorismatase family
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF00106 (2/2) short chain dehydrogenase
precursor_groups_7521 56.76 +- 14.01 4 0 0 0 0.25 +- 0.30 4 12

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
PF18029 (4/4) Glyoxalase-like domain
PF12704 (4/4) MacB-like periplasmic core domain
PF12697 (4/4) Alpha/beta hydrolase family
PF08281 (4/4) Sigma-70, region 4
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07730 (4/4) Histidine kinase
PF04542 (4/4) Sigma-70 region 2
PF02687 (4/4) FtsX-like permease family
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
PF00005 (4/4) ABC transporter
precursor_groups_14923 74.95 +- 7.82 3 0 3 0 0.13 +- 0.11 3 6

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF10091 (3/3) Putative glucoamylase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00232 (3/3) Glycosyl hydrolase family 1
precursor_groups_35514 308.15 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

PF18631 (2/2) Cucumopine synthase C-terminal helical bundle domain
PF13546 (2/2) DDE superfamily endonuclease
PF02195 (2/2) ParB-like nuclease domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_60669 138.27 +- 35.07 2 0 0 0 0.02 +- 0.01 2 4

PF01341 (2/2) Glycosyl hydrolases family 6
PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF00041 (2/2) Fibronectin type III domain
precursor_groups_70595 148.57 +- 0.00 2 0 2 2 0.01 +- 0.01 2 5

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00733 (2/2) Asparagine synthase
PF00221 (2/2) Aromatic amino acid lyase
precursor_groups_39124 163.88 +- 25.21 2 0 0 0 0.05 +- 0.08 2 15

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF18029 (1/2) Glyoxalase-like domain
PF13671 (1/2) AAA domain
PF13578 (1/2) Methyltransferase domain
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF05593 (1/2) RHS Repeat
PF03527 (1/2) RHS protein
PF01580 (1/2) FtsK/SpoIIIE family
PF01476 (1/2) LysM domain
precursor_groups_65141 135.86 +- 49.86 2 0 0 0 0.03 +- 0.04 2 4

PF05653 (2/2) Magnesium transporter NIPA
PF03576 (2/2) Peptidase family S58
PF01494 (2/2) FAD binding domain
PF00293 (2/2) NUDIX domain
precursor_groups_3710 20.35 +- 4.34 4 0 0 0 0.17 +- 0.29 4 8

PF03745 (4/4) Domain of unknown function (DUF309)
TIGR02434 (2/4) precorrin-6A synthase (deacetylating)
PF17837 (2/4) 4'-phosphopantetheinyl transferase N-terminal domain
PF12796 (2/4) Ankyrin repeats (3 copies)
PF01648 (2/4) 4'-phosphopantetheinyl transferase superfamily
PF00590 (2/4) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00149 (2/4) Calcineurin-like phosphoesterase
PF00027 (2/4) Cyclic nucleotide-binding domain
precursor_groups_3716 62.55 +- 5.10 3 0 2 0 0.22 +- 0.26 3 16

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (3/3) FCD domain
PF05544 (3/3) Proline racemase
PF04324 (3/3) BFD-like [2Fe-2S] binding domain
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_groups_3715 238.29 +- 156.38 7 0 1 0 0.02 +- 0.03 7 4

TIGR00574 (4/7) DNA ligase I, ATP-dependent (dnl1)
PF04679 (4/7) ATP dependent DNA ligase C terminal region
PF01068 (4/7) ATP dependent DNA ligase domain
PF00067 (4/7) Cytochrome P450
precursor_groups_37424 497.62 +- 2.38 2 0 0 0 0.03 +- 0.02 2 12

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/2) AAA-like domain
PF12642 (2/2) Conjugative transposon protein TcpC
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00877 (2/2) NlpC/P60 family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF13406 (1/2) Transglycosylase SLT domain
PF00691 (1/2) OmpA family
precursor_groups_43494 242.64 +- 117.60 3 0 3 0 0.04 +- 0.05 3 15

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF03060 (3/3) Nitronate monooxygenase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00698 (3/3) Acyl transferase domain
PF00664 (3/3) ABC transporter transmembrane region
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
TIGR01426 (2/3) glycosyltransferase, MGT family
PF05270 (2/3) Alpha-L-arabinofuranosidase B (ABFB) domain
precursor_groups_831 97.87 +- 63.58 7 0 0 0 0.08 +- 0.19 7 6

PF03009 (7/7) Glycerophosphoryl diester phosphodiesterase family
PF13185 (4/7) GAF domain
PF08448 (4/7) PAS fold
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
PF04972 (4/7) BON domain
PF00571 (4/7) CBS domain
precursor_groups_29403 35.83 +- 7.17 2 0 1 0 0.06 +- 0.02 2 6

PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06439 (2/2) Domain of Unknown Function (DUF1080)
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_groups_12692 689.68 +- 649.84 8 0 8 0 0.09 +- 0.15 8 28

TIGR01525 (8/8) heavy metal translocating P-type ATPase
PF04314 (8/8) Copper chaperone PCu(A)C
PF03929 (8/8) PepSY-associated TM region
PF01965 (8/8) DJ-1/PfpI family
PF00702 (8/8) haloacid dehalogenase-like hydrolase
PF00403 (8/8) Heavy-metal-associated domain
PF00122 (8/8) E1-E2 ATPase
TIGR01746 (7/8) thioester reductase domain
TIGR01733 (7/8) amino acid adenylation domain
TIGR00747 (7/8) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (7/8) AMP-binding enzyme C-terminal domain
PF10862 (7/8) FcoT-like thioesterase domain
PF08545 (7/8) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (7/8) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (7/8) Male sterility protein
PF07690 (7/8) Major Facilitator Superfamily
PF05118 (7/8) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (7/8) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (7/8) Periplasmic binding protein
PF01032 (7/8) FecCD transport family
PF00668 (7/8) Condensation domain
PF00550 (7/8) Phosphopantetheine attachment site
PF00501 (7/8) AMP-binding enzyme
PF00005 (7/8) ABC transporter
PF01794 (6/8) Ferric reductase like transmembrane component
TIGR02937 (4/8) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/8) Sigma-70, region 4
PF04542 (4/8) Sigma-70 region 2
precursor_groups_68805 269.54 +- 250.46 2 0 0 0 0.11 +- 0.27 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00481 (2/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF07690 (2/2) Major Facilitator Superfamily
PF01161 (2/2) Phosphatidylethanolamine-binding protein
PF00857 (2/2) Isochorismatase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_29900 1421.75 +- 4.76 4 0 4 0 0.01 +- 0.00 4 7

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (4/4) Condensation domain
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
precursor_groups_43018 793.37 +- 608.40 3 0 3 0 0.07 +- 0.21 3 8

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08242 (3/3) Methyltransferase domain
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_71012 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 3

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain
precursor_groups_43872 74.66 +- 5.34 2 0 1 0 0.08 +- 0.06 2 7

PF00857 (2/2) Isochorismatase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF14759 (1/2) Reductase C-terminal
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF00561 (1/2) alpha/beta hydrolase fold
PF00067 (1/2) Cytochrome P450
precursor_groups_3396 58.10 +- 4.30 2 0 0 0 0.19 +- 0.33 2 20

PF07690 (2/2) Major Facilitator Superfamily
TIGR02434 (1/2) precorrin-6A synthase (deacetylating)
TIGR00838 (1/2) argininosuccinate lyase
TIGR00836 (1/2) ammonium transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF14559 (1/2) Tetratricopeptide repeat
PF13577 (1/2) SnoaL-like domain
PF13432 (1/2) Tetratricopeptide repeat
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07732 (1/2) Multicopper oxidase
PF07731 (1/2) Multicopper oxidase
PF04343 (1/2) Protein of unknown function, DUF488
PF04199 (1/2) Putative cyclase
PF03745 (1/2) Domain of unknown function (DUF309)
PF00909 (1/2) Ammonium Transporter Family
PF00590 (1/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00206 (1/2) Lyase
precursor_groups_20705 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_1846 865.48 +- 694.52 2 0 1 1 0.05 +- 0.11 2 9

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
precursor_groups_18168 226.51 +- 44.39 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_groups_83891 8.15 +- 0.00 2 0 0 0 0.25 +- 0.29 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF02018 (2/2) Carbohydrate binding domain
PF00704 (2/2) Glycosyl hydrolases family 18
PF00041 (2/2) Fibronectin type III domain
precursor_groups_34424 217.51 +- 111.53 3 0 3 0 0.08 +- 0.21 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_14852 332.28 +- 117.15 5 0 0 5 0.01 +- 0.01 5 5

TIGR04267 (5/5) HEXXH motif domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF04055 (5/5) Radical SAM superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00067 (5/5) Cytochrome P450
precursor_groups_8941 24.48 +- 4.78 7 0 7 0 0.17 +- 0.05 7 3

PF17851 (7/7) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (7/7) Glycosyl hydrolases family 43
PF00106 (7/7) short chain dehydrogenase
precursor_groups_16970 389.37 +- 400.51 5 0 0 0 0.10 +- 0.17 5 8

PF13411 (5/5) MerR HTH family regulatory protein
PF07739 (5/5) TipAS antibiotic-recognition domain
PF03033 (5/5) Glycosyltransferase family 28 N-terminal domain
PF01551 (5/5) Peptidase family M23
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00005 (5/5) ABC transporter
PF12679 (4/5) ABC-2 family transporter protein
PF00201 (3/5) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_10022 37.42 +- 1.08 2 0 0 0 0.11 +- 0.06 2 4

PF08241 (2/2) Methyltransferase domain
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_44052 91.34 +- 41.59 3 0 0 0 0.06 +- 0.13 3 9

PF13613 (3/3) Helix-turn-helix of DDE superfamily endonuclease
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13359 (3/3) DDE superfamily endonuclease
PF07690 (3/3) Major Facilitator Superfamily
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF13669 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13377 (2/3) Periplasmic binding protein-like domain
PF00356 (2/3) Bacterial regulatory proteins, lacI family
precursor_groups_733 5756.47 +- 1500.30 3 0 3 3 0.01 +- 0.01 3 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00005 (3/3) ABC transporter
TIGR01189 (2/3) heme ABC exporter, ATP-binding protein CcmA
PF12698 (2/3) ABC-2 family transporter protein
precursor_groups_9949 199.61 +- 190.39 2 0 1 0 0.04 +- 0.10 2 14

TIGR03925 (1/2) type VII secretion protein EccCb
TIGR03924 (1/2) type VII secretion protein EccCa
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
PF17866 (1/2) AAA lid domain
PF13229 (1/2) Right handed beta helix region
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF08241 (1/2) Methyltransferase domain
PF07931 (1/2) Chloramphenicol phosphotransferase-like protein
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF03640 (1/2) Secreted repeat of unknown function
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01580 (1/2) FtsK/SpoIIIE family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_3377 291.83 +- 427.34 4 0 0 0 0.07 +- 0.15 4 2

PF01292 (3/4) Prokaryotic cytochrome b561
PF00174 (3/4) Oxidoreductase molybdopterin binding domain
precursor_groups_73060 181.69 +- 108.56 2 0 2 0 0.03 +- 0.03 2 4

PF13378 (2/2) Enolase C-terminal domain-like
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
precursor_groups_40285 280.43 +- 183.86 3 0 0 0 0.02 +- 0.05 3 4

PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF00294 (3/3) pfkB family carbohydrate kinase
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
precursor_groups_21007 165.12 +- 57.92 5 0 0 0 0.02 +- 0.01 5 2

PF00583 (5/5) Acetyltransferase (GNAT) family
PF00155 (5/5) Aminotransferase class I and II
precursor_groups_54248 630.67 +- 401.33 2 0 2 0 0.02 +- 0.01 2 5

PF08241 (2/2) Methyltransferase domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03795 (2/2) YCII-related domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (2/2) Condensation domain
precursor_groups_48297 156.00 +- 104.00 2 0 0 0 0.02 +- 0.02 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_40356 152.60 +- 103.30 3 0 2 3 0.05 +- 0.05 3 16

TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
TIGR00128 (3/3) malonyl CoA-acyl carrier protein transacylase
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13537 (3/3) Glutamine amidotransferase domain
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00733 (3/3) Asparagine synthase
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
TIGR00421 (2/3) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/3) decarboxylase, UbiD family
PF08242 (2/3) Methyltransferase domain
PF02441 (2/3) Flavoprotein
PF01977 (2/3) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
precursor_groups_15014 18.55 +- 5.04 6 0 0 0 0.19 +- 0.36 6 9

TIGR00465 (6/6) ketol-acid reductoisomerase
PF12902 (6/6) Ferritin-like
PF08281 (6/6) Sigma-70, region 4
PF07991 (6/6) Acetohydroxy acid isomeroreductase, NADPH-binding domain
PF04542 (6/6) Sigma-70 region 2
PF01450 (6/6) Acetohydroxy acid isomeroreductase, catalytic domain
PF00903 (6/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF13191 (3/6) AAA ATPase domain
precursor_groups_6100 91.67 +- 8.10 2 0 0 0 0.10 +- 0.13 2 12

PF17754 (2/2) MftR C-terminal domain
PF14759 (2/2) Reductase C-terminal
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF11528 (2/2) Protein of unknown function (DUF3224)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_groups_64922 16.45 +- 2.12 2 0 0 0 0.12 +- 0.23 2 5

PF13228 (2/2) Domain of unknown function (DUF4037)
PF08713 (2/2) DNA alkylation repair enzyme
PF07528 (2/2) DZF domain
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_27693 2306.17 +- 1837.87 4 0 4 4 0.05 +- 0.11 4 13

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00027 (4/4) methyltransferase, TIGR00027 family
PF04072 (4/4) Leucine carboxyl methyltransferase
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (4/4) CPBP intramembrane metalloprotease
PF01061 (4/4) ABC-2 type transporter
PF00881 (4/4) Nitroreductase family
PF00149 (4/4) Calcineurin-like phosphoesterase
PF00005 (4/4) ABC transporter
TIGR03723 (2/4) tRNA threonylcarbamoyl adenosine modification protein TsaD
PF02665 (2/4) Nitrate reductase gamma subunit
PF00814 (2/4) Glycoprotease family
precursor_groups_22684 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
precursor_groups_71437 344.00 +- 172.00 2 0 0 0 0.02 +- 0.02 2 2

PF03972 (2/2) MmgE/PrpD family
PF00857 (2/2) Isochorismatase family
precursor_groups_24458 115.93 +- 84.07 2 0 0 0 0.07 +- 0.17 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF01227 (2/2) GTP cyclohydrolase I
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00293 (2/2) NUDIX domain
precursor_groups_4879 1072.50 +- 357.50 2 0 0 0 0.01 +- 0.01 2 15

TIGR01928 (2/2) o-succinylbenzoate synthase
PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13378 (2/2) Enolase C-terminal domain-like
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF05199 (2/2) GMC oxidoreductase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (2/2) Prolyl oligopeptidase family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
precursor_groups_7251 107.87 +- 64.59 8 0 4 0 0.09 +- 0.19 8 2

PF07702 (8/8) UTRA domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
precursor_groups_48348 430.00 +- 215.00 2 0 0 0 0.03 +- 0.03 2 8

PF13378 (2/2) Enolase C-terminal domain-like
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_86111 61.85 +- 44.39 2 0 0 0 0.10 +- 0.26 2 6

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13459 (2/2) 4Fe-4S single cluster domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF07681 (1/2) DoxX
precursor_groups_64817 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_60393 2222.59 +- 873.41 2 0 0 2 0.01 +- 0.02 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03473 (2/2) MOSC domain
PF01523 (2/2) Putative modulator of DNA gyrase
PF01061 (2/2) ABC-2 type transporter
PF00334 (2/2) Nucleoside diphosphate kinase
PF00005 (2/2) ABC transporter
precursor_groups_23209 41.34 +- 27.70 4 0 0 0 0.08 +- 0.13 4 7

PF13424 (4/4) Tetratricopeptide repeat
PF07719 (4/4) Tetratricopeptide repeat
PF07504 (4/4) Fungalysin/Thermolysin Propeptide Motif
PF03413 (4/4) Peptidase propeptide and YPEB domain
PF02868 (4/4) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (4/4) Thermolysin metallopeptidase, catalytic domain
PF00348 (4/4) Polyprenyl synthetase
precursor_groups_27761 1387.10 +- 579.68 4 0 0 0 0.02 +- 0.02 4 7

PF08666 (4/4) SAF domain
PF07811 (4/4) TadE-like protein
PF03704 (4/4) Bacterial transcriptional activator domain
PF01476 (4/4) LysM domain
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF13400 (2/4) Putative Flp pilus-assembly TadE/G-like
precursor_groups_69821 580.50 +- 193.50 2 0 0 0 0.01 +- 0.01 2 5

PF13577 (2/2) SnoaL-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF01638 (1/2) HxlR-like helix-turn-helix
precursor_groups_870 165.90 +- 94.10 2 0 0 0 0.18 +- 0.22 2 11

TIGR02637 (1/2) rhamnose ABC transporter, rhamnose-binding protein
TIGR00247 (1/2) conserved hypothetical protein, YceG family
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF05336 (1/2) L-rhamnose mutarotase
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02618 (1/2) YceG-like family
PF02610 (1/2) L-arabinose isomerase
PF01494 (1/2) FAD binding domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00005 (1/2) ABC transporter
precursor_groups_10833 43.84 +- 8.75 9 0 0 0 0.17 +- 0.21 9 7

TIGR00996 (9/9) virulence factor Mce family protein
PF13577 (9/9) SnoaL-like domain
PF11887 (9/9) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (9/9) MlaD protein
PF02405 (9/9) Permease MlaE
PF00005 (9/9) ABC transporter
PF13406 (8/9) Transglycosylase SLT domain
precursor_groups_15312 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_groups_15314 90.54 +- 85.65 5 0 0 0 0.13 +- 0.31 5 9

TIGR01840 (5/5) esterase, PHB depolymerase family
PF14016 (5/5) Protein of unknown function (DUF4232)
PF10503 (5/5) Esterase PHB depolymerase
TIGR00666 (4/5) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF02113 (4/5) D-Ala-D-Ala carboxypeptidase 3 (S13) family
TIGR00086 (3/5) SsrA-binding protein
PF17820 (3/5) PDZ domain
PF03572 (3/5) Peptidase family S41
PF01668 (3/5) SmpB protein
precursor_groups_27161 82.80 +- 40.17 3 0 3 0 0.09 +- 0.18 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00266 (3/3) Aminotransferase class-V
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_42281 165.73 +- 61.23 3 0 3 0 0.11 +- 0.15 3 17

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
TIGR01746 (2/3) thioester reductase domain
TIGR01733 (2/3) amino acid adenylation domain
PF07993 (2/3) Male sterility protein
PF05118 (2/3) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (2/3) Condensation domain
precursor_groups_33329 136.62 +- 123.38 2 0 0 0 0.08 +- 0.12 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF09350 (2/2) Domain of unknown function (DUF1992)
precursor_groups_629 303.37 +- 245.18 5 0 0 3 0.01 +- 0.03 5 1

PF13560 (4/5) Helix-turn-helix domain
precursor_groups_70652 178.96 +- 22.96 2 0 0 0 0.10 +- 0.22 2 25

TIGR01792 (2/2) urease, alpha subunit
TIGR00836 (2/2) ammonium transporter
TIGR00193 (2/2) urease, gamma subunit
TIGR00192 (2/2) urease, beta subunit
TIGR00101 (2/2) urease accessory protein UreG
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF04041 (2/2) beta-1,4-mannooligosaccharide phosphorylase
PF03253 (2/2) Urea transporter
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01979 (2/2) Amidohydrolase family
PF01774 (2/2) UreD urease accessory protein
PF01730 (2/2) UreF
PF00909 (2/2) Ammonium Transporter Family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_groups_70659 83.65 +- 5.65 2 0 0 0 0.04 +- 0.04 2 4

PF16757 (2/2) Alpha-L-fucosidase C-terminal domain
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01120 (2/2) Alpha-L-fucosidase
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
precursor_groups_8540 213.07 +- 45.29 7 0 7 0 0.01 +- 0.00 7 3

TIGR02050 (7/7) carboxylate-amine ligase, YbdK family
PF09860 (7/7) Uncharacterized protein conserved in bacteria (DUF2087)
PF04107 (7/7) Glutamate-cysteine ligase family 2(GCS2)
precursor_groups_22919 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_624 126.40 +- 69.24 14 0 1 0 0.15 +- 0.17 14 15

TIGR01727 (12/14) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13977 (12/14) BetI-type transcriptional repressor, C-terminal
PF12770 (12/14) CHAT domain
PF08352 (12/14) Oligopeptide/dipeptide transporter, C-terminal region
PF04371 (12/14) Porphyromonas-type peptidyl-arginine deiminase
PF00440 (12/14) Bacterial regulatory proteins, tetR family
PF00005 (12/14) ABC transporter
TIGR00193 (11/14) urease, gamma subunit
PF01979 (11/14) Amidohydrolase family
PF00699 (11/14) Urease beta subunit
PF00547 (11/14) Urease, gamma subunit
PF00528 (11/14) Binding-protein-dependent transport system inner membrane component
PF00496 (11/14) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00449 (11/14) Urease alpha-subunit, N-terminal domain
PF00069 (7/14) Protein kinase domain
precursor_groups_4273 52.88 +- 8.23 2 0 0 0 0.06 +- 0.03 2 5

TIGR00589 (2/2) methylated-DNA--[protein]-cysteine S-methyltransferase
PF07690 (2/2) Major Facilitator Superfamily
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF02870 (2/2) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
precursor_groups_4272 312.64 +- 408.96 3 0 0 0 0.06 +- 0.07 3 3

PF13370 (2/3) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/3) Methyltransferase domain
PF00753 (2/3) Metallo-beta-lactamase superfamily
precursor_groups_36756 320.46 +- 139.19 2 0 2 0 0.04 +- 0.03 2 12

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (2/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF12849 (2/2) PBP superfamily domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF01676 (2/2) Metalloenzyme superfamily
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00384 (2/2) Molybdopterin oxidoreductase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (2/2) Glutamine amidotransferase class-I
PF00005 (2/2) ABC transporter
precursor_groups_62733 262.45 +- 4.45 2 0 0 0 0.02 +- 0.02 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF05853 (2/2) beta-keto acid cleavage enzyme
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00474 (2/2) Sodium:solute symporter family
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_1629 447.81 +- 72.19 2 0 1 0 0.06 +- 0.19 2 20

TIGR03947 (1/2) capreomycidine synthase
TIGR01733 (1/2) amino acid adenylation domain
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13546 (1/2) DDE superfamily endonuclease
PF13377 (1/2) Periplasmic binding protein-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07582 (1/2) AP endonuclease family 2 C terminus
PF03621 (1/2) MbtH-like protein
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00266 (1/2) Aminotransferase class-V
PF00155 (1/2) Aminotransferase class I and II
precursor_groups_34950 61.88 +- 35.62 2 0 0 0 0.10 +- 0.11 2 7

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF07690 (2/2) Major Facilitator Superfamily
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00122 (2/2) E1-E2 ATPase
PF00877 (1/2) NlpC/P60 family
precursor_groups_34951 26.58 +- 5.62 3 0 0 0 0.08 +- 0.07 3 4

TIGR00369 (3/3) uncharacterized domain 1
PF11695 (3/3) Domain of unknown function (DUF3291)
PF03061 (3/3) Thioesterase superfamily
PF01638 (3/3) HxlR-like helix-turn-helix
precursor_groups_8121 329.74 +- 323.40 9 0 9 0 0.11 +- 0.27 9 10

TIGR03025 (9/9) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (9/9) Glycosyl transferases group 1
PF13480 (9/9) Acetyltransferase (GNAT) domain
PF13439 (9/9) Glycosyltransferase Family 4
PF04932 (9/9) O-Antigen ligase
PF03777 (9/9) ChpA-C
PF03023 (9/9) Lipid II flippase MurJ
PF02397 (9/9) Bacterial sugar transferase
PF01522 (9/9) Polysaccharide deacetylase
PF00534 (9/9) Glycosyl transferases group 1
precursor_groups_1627 131.75 +- 65.81 42 0 29 42 0.05 +- 0.04 42 3

PF13649 (42/42) Methyltransferase domain
PF07690 (42/42) Major Facilitator Superfamily
PF04055 (42/42) Radical SAM superfamily
precursor_groups_3816 206.75 +- 143.57 8 0 1 0 0.03 +- 0.03 8 3

PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF01039 (8/8) Carboxyl transferase domain
PF00501 (8/8) AMP-binding enzyme
precursor_groups_1150 191.71 +- 92.58 55 0 53 55 0.14 +- 0.11 55 12

TIGR03882 (55/55) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (55/55) thiazole/oxazole-forming peptide maturase, SagD family component
PF13191 (55/55) AAA ATPase domain
PF03704 (55/55) Bacterial transcriptional activator domain
PF02624 (55/55) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (55/55) Transcriptional regulatory protein, C terminal
TIGR03605 (54/55) SagB-type dehydrogenase domain
PF00881 (53/55) Nitroreductase family
PF14028 (52/55) Lantibiotic biosynthesis dehydratase C-term
PF04738 (52/55) Lantibiotic dehydratase, N terminus
PF00005 (52/55) ABC transporter
PF01061 (51/55) ABC-2 type transporter
precursor_groups_27509 94.07 +- 11.89 4 0 0 0 0.16 +- 0.14 4 16

TIGR01182 (4/4) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13407 (4/4) Periplasmic binding protein domain
PF13378 (4/4) Enolase C-terminal domain-like
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07729 (4/4) FCD domain
PF05025 (4/4) RbsD / FucU transport protein family
PF04909 (4/4) Amidohydrolase
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (4/4) Branched-chain amino acid transport system / permease component
PF01081 (4/4) KDPG and KHG aldolase
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00248 (4/4) Aldo/keto reductase family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00005 (4/4) ABC transporter
precursor_groups_51585 57.99 +- 0.06 2 0 2 0 0.09 +- 0.06 2 13

TIGR02159 (2/2) phenylacetate-CoA oxygenase, PaaJ subunit
TIGR02158 (2/2) phenylacetate-CoA oxygenase, PaaI subunit
TIGR02157 (2/2) phenylacetate-CoA oxygenase, PaaH subunit
TIGR02156 (2/2) phenylacetate-CoA oxygenase, PaaG subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF06243 (2/2) Phenylacetic acid degradation B
PF05138 (2/2) Phenylacetic acid catabolic protein
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF01883 (2/2) Iron-sulfur cluster assembly protein
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_34558 218.10 +- 64.15 3 0 0 0 0.05 +- 0.14 3 20

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01341 (3/3) aconitate hydratase 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01613 (3/3) Flavin reductase like domain
PF00694 (3/3) Aconitase C-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00330 (3/3) Aconitase family (aconitate hydratase)
PF00296 (3/3) Luciferase-like monooxygenase
PF00285 (3/3) Citrate synthase, C-terminal domain
PF00072 (3/3) Response regulator receiver domain
precursor_groups_11745 59.68 +- 25.10 6 0 1 0 0.16 +- 0.06 6 9

PF14310 (6/6) Fibronectin type III-like domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF11625 (6/6) Protein of unknown function (DUF3253)
PF01915 (6/6) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00933 (6/6) Glycosyl hydrolase family 3 N terminal domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00150 (6/6) Cellulase (glycosyl hydrolase family 5)
precursor_groups_20640 28.43 +- 16.93 4 0 2 4 0.18 +- 0.15 4 11

TIGR02493 (4/4) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (4/4) formate acetyltransferase
PF04055 (4/4) Radical SAM superfamily
PF02901 (4/4) Pyruvate formate lyase-like
PF01228 (4/4) Glycine radical
PF13247 (3/4) 4Fe-4S dicluster domain
PF04879 (3/4) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (3/4) Molydopterin dinucleotide binding domain
PF00384 (3/4) Molybdopterin oxidoreductase
PF00355 (3/4) Rieske [2Fe-2S] domain
PF00037 (3/4) 4Fe-4S binding domain
precursor_groups_5360 142.41 +- 72.76 2 0 2 0 0.06 +- 0.04 2 5

PF13833 (2/2) EF-hand domain pair
PF13499 (2/2) EF-hand domain pair
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07969 (2/2) Amidohydrolase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_27500 38.25 +- 3.59 2 0 0 0 0.11 +- 0.18 2 5

PF11239 (2/2) Protein of unknown function (DUF3040)
PF07690 (2/2) Major Facilitator Superfamily
PF04203 (2/2) Sortase domain
PF02610 (2/2) L-arabinose isomerase
PF00999 (2/2) Sodium/hydrogen exchanger family
precursor_groups_15406 264.71 +- 55.43 6 0 0 0 0.04 +- 0.03 6 8

PF13378 (6/6) Enolase C-terminal domain-like
PF07729 (6/6) FCD domain
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00754 (6/6) F5/8 type C domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00480 (6/6) ROK family
PF00392 (6/6) Bacterial regulatory proteins, gntR family
precursor_groups_58371 257.12 +- 18.79 2 0 0 0 0.04 +- 0.06 2 8

PF05426 (2/2) Alginate lyase
PF05345 (2/2) Putative Ig domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00295 (2/2) Glycosyl hydrolases family 28
PF00135 (2/2) Carboxylesterase family
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_groups_9546 104.65 +- 49.74 9 0 9 0 0.06 +- 0.04 9 11

TIGR01733 (9/9) amino acid adenylation domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00698 (9/9) Acyl transferase domain
PF00668 (9/9) Condensation domain
PF00551 (9/9) Formyl transferase
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF00067 (9/9) Cytochrome P450
precursor_groups_20882 92.33 +- 61.75 2 0 0 0 0.08 +- 0.15 2 9

PF14606 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF06580 (2/2) Histidine kinase
PF04397 (2/2) LytTr DNA-binding domain
PF03640 (2/2) Secreted repeat of unknown function
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00474 (2/2) Sodium:solute symporter family
PF00296 (2/2) Luciferase-like monooxygenase
PF00072 (2/2) Response regulator receiver domain
precursor_groups_61737 520.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF16916 (2/2) Dimerisation domain of Zinc Transporter
PF07729 (2/2) FCD domain
PF01545 (2/2) Cation efflux family
PF01266 (2/2) FAD dependent oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_1539 14.88 +- 1.44 28 0 0 0 0.20 +- 0.33 28 5

PF14472 (28/28) Domain of unknown function (DUF4429)
PF08241 (28/28) Methyltransferase domain
PF00106 (28/28) short chain dehydrogenase
PF09851 (27/28) Short C-terminal domain
PF13231 (26/28) Dolichyl-phosphate-mannose-protein mannosyltransferase
precursor_groups_717 2711.17 +- 3887.00 5 0 2 2 0.04 +- 0.07 5 1

PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
precursor_groups_716 56.82 +- 22.20 7 0 1 0 0.06 +- 0.06 7 4

PF01471 (7/7) Putative peptidoglycan binding domain
TIGR00476 (6/7) selenide, water dikinase
PF02769 (6/7) AIR synthase related protein, C-terminal domain
PF00586 (6/7) AIR synthase related protein, N-terminal domain
precursor_groups_71839 31.21 +- 1.73 2 0 1 0 0.17 +- 0.07 2 11

PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF10370 (1/2) Domain of unknown function (DUF2437)
PF04909 (1/2) Amidohydrolase
PF04672 (1/2) S-adenosyl methyltransferase
PF04199 (1/2) Putative cyclase
PF01979 (1/2) Amidohydrolase family
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00860 (1/2) Permease family
precursor_groups_1023 335.87 +- 113.77 26 0 26 26 0.01 +- 0.02 26 3

PF13471 (26/26) Transglutaminase-like superfamily
PF00733 (26/26) Asparagine synthase
PF05402 (14/26) Coenzyme PQQ synthesis protein D (PqqD)
precursor_groups_1530 136.93 +- 98.85 4 0 1 1 0.04 +- 0.06 4 4

TIGR01167 (2/4) LPXTG cell wall anchor domain
PF10824 (2/4) Excreted virulence factor EspC, type VII ESX diderm
PF06259 (2/4) Alpha/beta hydrolase
PF00561 (2/4) alpha/beta hydrolase fold
precursor_groups_1535 30.92 +- 4.49 16 0 0 16 0.10 +- 0.10 16 3

PF02547 (16/16) Queuosine biosynthesis protein
PF00881 (16/16) Nitroreductase family
PF00106 (16/16) short chain dehydrogenase
precursor_groups_1534 288.61 +- 209.89 8 0 8 8 0.05 +- 0.08 8 4

PF05147 (8/8) Lanthionine synthetase C-like protein
PF00069 (8/8) Protein kinase domain
PF13302 (5/8) Acetyltransferase (GNAT) domain
PF00294 (4/8) pfkB family carbohydrate kinase
precursor_groups_76 81.27 +- 36.37 18 0 0 0 0.16 +- 0.24 18 10

TIGR01727 (15/18) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (15/18) Oligopeptide/dipeptide transporter, C-terminal region
PF00005 (15/18) ABC transporter
PF12911 (14/18) N-terminal TM domain of oligopeptide transport permease C
PF00528 (14/18) Binding-protein-dependent transport system inner membrane component
PF00496 (14/18) Bacterial extracellular solute-binding proteins, family 5 Middle
PF03425 (9/18) Carbohydrate binding domain (family 11)
PF01915 (9/18) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (9/18) Glycosyl hydrolase family 3 N terminal domain
PF00232 (9/18) Glycosyl hydrolase family 1
precursor_groups_1536 109.55 +- 55.41 46 0 0 0 0.05 +- 0.04 46 7

PF02668 (46/46) Taurine catabolism dioxygenase TauD, TfdA family
PF01925 (46/46) Sulfite exporter TauE/SafE
PF01070 (46/46) FMN-dependent dehydrogenase
TIGR00843 (44/46) benzoate transporter
PF03594 (44/46) Benzoate membrane transport protein
PF12697 (39/46) Alpha/beta hydrolase family
PF12897 (29/46) Alanine-glyoxylate amino-transferase
precursor_groups_50983 192.32 +- 7.43 2 0 2 0 0.12 +- 0.31 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_39308 797.59 +- 719.07 2 0 0 0 0.14 +- 0.28 2 8

TIGR03816 (2/2) helicase/secretion neighborhood TadE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF00482 (2/2) Type II secretion system (T2SS), protein F
TIGR03819 (1/2) helicase/secretion neighborhood ATPase
TIGR03815 (1/2) helicase/secretion neighborhood CpaE-like protein
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00437 (1/2) Type II/IV secretion system protein
precursor_groups_17315 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_groups_45146 95.53 +- 3.39 2 0 0 0 0.10 +- 0.05 2 9

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01301 (2/2) Glycosyl hydrolases family 35
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF13377 (1/2) Periplasmic binding protein-like domain
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_groups_68 96.75 +- 26.33 3 0 0 0 0.03 +- 0.04 3 2

PF13649 (3/3) Methyltransferase domain
PF05685 (3/3) Putative restriction endonuclease
precursor_groups_8232 665.45 +- 451.36 11 0 0 0 0.05 +- 0.06 11 5

PF05426 (11/11) Alginate lyase
PF01547 (11/11) Bacterial extracellular solute-binding protein
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF00295 (11/11) Glycosyl hydrolases family 28
PF00135 (6/11) Carboxylesterase family
precursor_groups_64 873.96 +- 2888.48 23 0 4 1 0.06 +- 0.14 23

No common domains found
precursor_groups_5019 2161.54 +- 2128.46 2 0 1 1 0.03 +- 0.07 2 23

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR02258 (1/2) 2'-5' RNA ligase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (1/2) Methyltransferase domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF12833 (1/2) Helix-turn-helix domain
PF05977 (1/2) Transmembrane secretion effector
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04828 (1/2) Glutathione-dependent formaldehyde-activating enzyme
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04672 (1/2) S-adenosyl methyltransferase
PF03466 (1/2) LysR substrate binding domain
PF02834 (1/2) LigT like Phosphoesterase
PF01966 (1/2) HD domain
PF01965 (1/2) DJ-1/PfpI family
PF01636 (1/2) Phosphotransferase enzyme family
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (1/2) ABC transporter
precursor_groups_63 283.61 +- 509.16 35 0 0 3 0.10 +- 0.13 35

No common domains found
precursor_groups_60 195.10 +- 103.11 11 0 1 0 0.13 +- 0.29 11 12

PF02446 (11/11) 4-alpha-glucanotransferase
PF01120 (10/11) Alpha-L-fucosidase
TIGR01727 (9/11) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13385 (9/11) Concanavalin A-like lectin/glucanases superfamily
PF13088 (9/11) BNR repeat-like domain
PF12911 (9/11) N-terminal TM domain of oligopeptide transport permease C
PF08352 (9/11) Oligopeptide/dipeptide transporter, C-terminal region
PF00884 (9/11) Sulfatase
PF00701 (9/11) Dihydrodipicolinate synthetase family
PF00528 (9/11) Binding-protein-dependent transport system inner membrane component
PF00496 (9/11) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (9/11) ABC transporter
precursor_groups_46767 334.62 +- 22.62 2 0 2 0 0.03 +- 0.01 2 6

PF13560 (2/2) Helix-turn-helix domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_27430 48.84 +- 11.60 2 0 2 0 0.23 +- 0.31 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01167 (2/2) LPXTG cell wall anchor domain
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14012 (2/2) Protein of unknown function (DUF4229)
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00375 (2/2) Sodium:dicarboxylate symporter family
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF01756 (1/2) Acyl-CoA oxidase
precursor_groups_41644 39.58 +- 17.56 2 0 1 0 0.11 +- 0.08 2 7

PF14361 (2/2) RsbT co-antagonist protein rsbRD N-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01740 (2/2) STAS domain
PF01645 (2/2) Conserved region in glutamate synthase
PF13411 (1/2) MerR HTH family regulatory protein
PF02627 (1/2) Carboxymuconolactone decarboxylase family
precursor_groups_28099 312.30 +- 137.83 4 0 0 0 0.04 +- 0.04 4 8

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF04909 (4/4) Amidohydrolase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF00248 (3/4) Aldo/keto reductase family
PF00107 (3/4) Zinc-binding dehydrogenase
PF05336 (2/4) L-rhamnose mutarotase
precursor_groups_13996 26.87 +- 15.22 3 0 0 0 0.13 +- 0.13 3 2

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF01872 (3/3) RibD C-terminal domain
precursor_groups_7872 54.37 +- 24.70 3 0 0 0 0.15 +- 0.18 3 8

TIGR03718 (3/3) integral membrane protein, TerC family
PF05331 (3/3) Protein of unknown function (DUF742)
PF03741 (3/3) Integral membrane protein TerC family
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF18029 (2/3) Glyoxalase-like domain
PF00378 (2/3) Enoyl-CoA hydratase/isomerase
PF00067 (2/3) Cytochrome P450
precursor_groups_7870 92.86 +- 0.00 2 0 0 2 0.03 +- 0.02 2 6

TIGR04188 (2/2) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14408 (2/2) Ribosomally synthesised peptide in actinomycetes
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_83319 132.91 +- 39.09 2 0 0 0 0.05 +- 0.09 2 7

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_32103 18.98 +- 4.73 4 0 0 0 0.16 +- 0.10 4 2

PF11575 (4/4) FhuF 2Fe-2S C-terminal domain
PF01794 (4/4) Ferric reductase like transmembrane component
precursor_groups_33458 127.11 +- 87.55 3 0 3 0 0.05 +- 0.04 3 3

TIGR04538 (3/3) cytochrome P450, cyclodipeptide synthase-associated
PF00857 (3/3) Isochorismatase family
PF00067 (3/3) Cytochrome P450
precursor_groups_28634 78.98 +- 4.56 3 0 3 0 0.15 +- 0.21 3 6

PF11991 (3/3) Tryptophan dimethylallyltransferase
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (3/3) Beta-eliminating lyase
precursor_groups_4657 230.14 +- 57.72 5 0 1 1 0.10 +- 0.15 5 2

PF01814 (5/5) Hemerythrin HHE cation binding domain
PF03364 (4/5) Polyketide cyclase / dehydrase and lipid transport
precursor_groups_1446 34.50 +- 9.35 7 0 0 0 0.12 +- 0.26 7 3

TIGR03296 (7/7) M6 family metalloprotease domain
PF09339 (7/7) IclR helix-turn-helix domain
PF03777 (7/7) ChpA-C
precursor_groups_66087 1361.71 +- 233.20 2 0 0 0 0.02 +- 0.00 2 17

TIGR02118 (2/2) conserved hypothetical protein
TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07110 (2/2) EthD domain
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF01636 (2/2) Phosphotransferase enzyme family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00108 (2/2) Thiolase, N-terminal domain
precursor_groups_4652 666.75 +- 483.93 10 0 1 7 0.06 +- 0.12 10 20

PF05331 (10/10) Protein of unknown function (DUF742)
PF03259 (10/10) Roadblock/LC7 domain
PF03029 (10/10) Conserved hypothetical ATP binding protein
PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain
PF01590 (10/10) GAF domain
PF00723 (10/10) Glycosyl hydrolases family 15
PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (10/10) NUDIX domain
PF13649 (9/10) Methyltransferase domain
PF02518 (9/10) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
TIGR04364 (7/10) methyltransferase, FxLD system
TIGR04363 (7/10) FxLD family lantipeptide
TIGR03891 (7/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (7/10) Lantibiotic biosynthesis dehydratase C-term
PF05147 (7/10) Lanthionine synthetase C-like protein
PF04738 (7/10) Lantibiotic dehydratase, N terminus
PF01135 (7/10) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (7/10) ABC transporter
PF01427 (5/10) D-ala-D-ala dipeptidase
precursor_groups_63068 435.50 +- 84.50 2 0 0 0 0.02 +- 0.02 2 5

PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03640 (2/2) Secreted repeat of unknown function
PF14246 (1/2) AefR-like transcriptional repressor, C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_37972 24.12 +- 8.30 3 0 0 0 0.18 +- 0.32 3 12

TIGR00765 (3/3) YihY family inner membrane protein
TIGR00105 (3/3) ribosomal protein bL31
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF05922 (3/3) Peptidase inhibitor I9
PF03631 (3/3) Virulence factor BrkB
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF01756 (3/3) Acyl-CoA oxidase
PF01197 (3/3) Ribosomal protein L31
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00082 (3/3) Subtilase family
PF11941 (2/3) Domain of unknown function (DUF3459)
PF00128 (2/3) Alpha amylase, catalytic domain
precursor_groups_10906 727.56 +- 472.72 9 0 0 0 0.04 +- 0.05 9 5

PF05426 (9/9) Alginate lyase
PF01547 (9/9) Bacterial extracellular solute-binding protein
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00295 (9/9) Glycosyl hydrolases family 28
PF00135 (6/9) Carboxylesterase family
precursor_groups_71782 215.00 +- 85.00 2 0 0 0 0.02 +- 0.03 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
TIGR03919 (1/2) type VII secretion protein EccB
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_groups_16575 236.78 +- 109.89 2 0 0 0 0.08 +- 0.15 2 8

PF14759 (2/2) Reductase C-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_groups_1417 53.50 +- 29.11 12 0 0 0 0.15 +- 0.06 12 10

PF14759 (12/12) Reductase C-terminal
PF13370 (12/12) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (12/12) Pyridine nucleotide-disulphide oxidoreductase
PF06314 (12/12) Acetoacetate decarboxylase (ADC)
PF02900 (12/12) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01557 (12/12) Fumarylacetoacetate (FAA) hydrolase family
PF00171 (12/12) Aldehyde dehydrogenase family
PF17940 (7/12) Tetracyclin repressor-like, C-terminal domain
PF00440 (7/12) Bacterial regulatory proteins, tetR family
PF07722 (6/12) Peptidase C26
precursor_groups_62100 221.88 +- 118.68 2 0 0 0 0.06 +- 0.09 2 8

PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12769 (1/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (1/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (1/2) NAD(P) transhydrogenase beta subunit
PF01262 (1/2) Alanine dehydrogenase/PNT, C-terminal domain
precursor_groups_81809 72.50 +- 12.83 2 0 0 0 0.17 +- 0.30 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00630 (2/2) excinuclease ABC subunit A
PF17760 (2/2) UvrA interaction domain
PF17755 (2/2) UvrA DNA-binding domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13280 (2/2) WYL domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF00140 (2/2) Sigma-70 factor, region 1.2
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_groups_21775 2101.96 +- 1163.07 4 0 4 0 0.04 +- 0.10 4 29

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01444 (4/4) methyltransferase, FkbM family
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07977 (4/4) FabA-like domain
PF05977 (4/4) Transmembrane secretion effector
PF05050 (4/4) Methyltransferase FkbM domain
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02729 (4/4) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01323 (4/4) DSBA-like thioredoxin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00185 (4/4) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (4/4) Beta-lactamase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1879 79.07 +- 52.58 32 0 0 0 0.09 +- 0.08 32 9

PF13581 (32/32) Histidine kinase-like ATPase domain
PF13492 (32/32) GAF domain
PF08447 (32/32) PAS fold
PF07228 (32/32) Stage II sporulation protein E (SpoIIE)
PF00149 (32/32) Calcineurin-like phosphoesterase
PF09348 (31/32) Domain of unknown function (DUF1990)
PF14158 (28/32) YndJ-like protein
PF11716 (28/32) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03446 (28/32) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_31344 285.71 +- 10.10 3 0 3 3 0.02 +- 0.00 3 5

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07690 (3/3) Major Facilitator Superfamily
PF00881 (3/3) Nitroreductase family
precursor_groups_9053 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_41068 10.84 +- 1.24 3 0 0 0 0.19 +- 0.10 3 4

PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF00672 (3/3) HAMP domain
precursor_groups_36552 203.62 +- 86.63 2 0 0 0 0.02 +- 0.01 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF07853 (2/2) Protein of unknown function (DUF1648)
PF04264 (2/2) YceI-like domain
precursor_groups_82316 889.37 +- 45.01 2 0 2 0 0.06 +- 0.17 2 27

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (2/2) GYF domain 2
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13421 (2/2) SPFH domain-Band 7 family
PF08281 (2/2) Sigma-70, region 4
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03824 (2/2) High-affinity nickel-transport protein
PF01070 (2/2) FMN-dependent dehydrogenase
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00067 (2/2) Cytochrome P450
TIGR01733 (1/2) amino acid adenylation domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/2) Male sterility protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
precursor_groups_33078 307.65 +- 79.35 2 0 0 0 0.06 +- 0.06 2 9

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14494 (2/2) Domain of unknown function (DUF4436)
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04371 (2/2) Porphyromonas-type peptidyl-arginine deiminase
PF01590 (2/2) GAF domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_13489 621.62 +- 375.01 4 0 0 1 0.08 +- 0.18 4 15

PF13649 (4/4) Methyltransferase domain
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00005 (4/4) ABC transporter
TIGR01208 (3/4) glucose-1-phosphate thymidylyltransferase
PF00483 (3/4) Nucleotidyl transferase
PF00196 (3/4) Bacterial regulatory proteins, luxR family
TIGR01181 (2/4) dTDP-glucose 4,6-dehydratase
PF16363 (2/4) GDP-mannose 4,6 dehydratase
PF14016 (2/4) Protein of unknown function (DUF4232)
PF05719 (2/4) Golgi phosphoprotein 3 (GPP34)
PF00535 (2/4) Glycosyl transferase family 2
PF00132 (2/4) Bacterial transferase hexapeptide (six repeats)
PF00069 (2/4) Protein kinase domain
precursor_groups_14593 39.61 +- 24.92 6 0 6 0 0.10 +- 0.09 6 4

PF05199 (6/6) GMC oxidoreductase
PF00732 (6/6) GMC oxidoreductase
PF00294 (6/6) pfkB family carbohydrate kinase
PF00248 (6/6) Aldo/keto reductase family
precursor_groups_14594 456.25 +- 207.42 5 0 5 5 0.02 +- 0.01 5 16

TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
TIGR00857 (5/5) dihydroorotase, multifunctional complex type
PF13537 (5/5) Glutamine amidotransferase domain
PF04303 (5/5) PrpF protein
PF03358 (5/5) NADPH-dependent FMN reductase
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01979 (5/5) Amidohydrolase family
PF01494 (5/5) FAD binding domain
PF00733 (5/5) Asparagine synthase
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF07690 (4/5) Major Facilitator Superfamily
PF00268 (4/5) Ribonucleotide reductase, small chain
precursor_groups_83225 614.71 +- 165.29 2 0 0 0 0.03 +- 0.02 2 10

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_151 458.70 +- 57.30 2 0 1 0 0.05 +- 0.17 2 16

PF08241 (2/2) Methyltransferase domain
PF13649 (1/2) Methyltransferase domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13378 (1/2) Enolase C-terminal domain-like
PF13242 (1/2) HAD-hyrolase-like
PF09364 (1/2) XFP N-terminal domain
PF09363 (1/2) XFP C-terminal domain
PF08007 (1/2) Cupin superfamily protein
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (1/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01300 (1/2) Telomere recombination
PF00723 (1/2) Glycosyl hydrolases family 15
PF00670 (1/2) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00156 (1/2) Phosphoribosyl transferase domain
precursor_groups_402 254.51 +- 191.20 2 0 0 0 0.12 +- 0.26 2 13

TIGR02365 (1/2) dihydroxyacetone kinase, L subunit
TIGR02363 (1/2) dihydroxyacetone kinase, DhaK subunit
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF09339 (1/2) IclR helix-turn-helix domain
PF06353 (1/2) Protein of unknown function (DUF1062)
PF05524 (1/2) PEP-utilising enzyme, N-terminal
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF02734 (1/2) DAK2 domain
PF02733 (1/2) Dak1 domain
PF01614 (1/2) Bacterial transcriptional regulator
PF01073 (1/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00230 (1/2) Major intrinsic protein
precursor_groups_32073 64.02 +- 2.74 4 0 0 0 0.12 +- 0.12 4 10

PF13586 (4/4) Transposase DDE domain
PF12802 (4/4) MarR family
PF07690 (4/4) Major Facilitator Superfamily
PF01327 (4/4) Polypeptide deformylase
PF00857 (4/4) Isochorismatase family
PF00106 (4/4) short chain dehydrogenase
TIGR02957 (3/4) RNA polymerase sigma-70 factor, TIGR02957 family
PF12680 (3/4) SnoaL-like domain
PF08281 (3/4) Sigma-70, region 4
PF04542 (3/4) Sigma-70 region 2
precursor_groups_404 390.15 +- 269.67 4 0 1 0 0.04 +- 0.12 4 10

PF16197 (2/4) Ketoacyl-synthetase C-terminal extension
PF14765 (2/4) Polyketide synthase dehydratase
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF08659 (2/4) KR domain
PF03055 (2/4) Retinal pigment epithelial membrane protein
PF02801 (2/4) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/4) Acyl transferase domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00109 (2/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/4) Cytochrome P450
precursor_groups_154 167.77 +- 155.24 14 0 0 0 0.14 +- 0.09 14 4

PF13400 (8/14) Putative Flp pilus-assembly TadE/G-like
PF07811 (8/14) TadE-like protein
PF00482 (8/14) Type II secretion system (T2SS), protein F
PF00437 (8/14) Type II/IV secretion system protein
precursor_groups_47968 1905.20 +- 308.06 3 0 3 3 0.02 +- 0.02 3 11

PF16864 (3/3) Dimerisation domain
PF13471 (3/3) Transglutaminase-like superfamily
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01494 (3/3) FAD binding domain
PF00891 (3/3) O-methyltransferase domain
PF00733 (3/3) Asparagine synthase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
precursor_groups_158 185.28 +- 110.94 6 0 1 0 0.04 +- 0.06 6

No common domains found
precursor_groups_32078 339.59 +- 305.41 2 0 1 1 0.14 +- 0.24 2 14

PF04978 (2/2) Protein of unknown function (DUF664)
TIGR04222 (1/2) TIGR04222 domain
PF13560 (1/2) Helix-turn-helix domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF09339 (1/2) IclR helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF05362 (1/2) Lon protease (S16) C-terminal proteolytic domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF00881 (1/2) Nitroreductase family
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
precursor_groups_52826 85.77 +- 37.61 2 0 0 0 0.12 +- 0.24 2 10

TIGR02815 (2/2) putative sugar isomerase, AgaS family
TIGR02810 (2/2) D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF08013 (2/2) Tagatose 6 phosphate kinase
PF07702 (2/2) UTRA domain
PF01869 (2/2) BadF/BadG/BcrA/BcrD ATPase family
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_2896 181.00 +- 77.00 2 0 0 0 0.01 +- 0.01 2 5

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF08306 (2/2) Glycosyl hydrolase family 98
PF02065 (2/2) Melibiase
PF00754 (2/2) F5/8 type C domain
precursor_groups_47496 32.68 +- 0.44 3 0 0 0 0.12 +- 0.14 3 4

PF13701 (3/3) Transposase DDE domain group 1
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01476 (3/3) LysM domain
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_19621 201.36 +- 56.02 5 0 0 0 0.04 +- 0.03 5 5

PF07729 (5/5) FCD domain
PF07690 (5/5) Major Facilitator Superfamily
PF04191 (5/5) Phospholipid methyltransferase
PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00392 (5/5) Bacterial regulatory proteins, gntR family
precursor_groups_16680 15.16 +- 5.87 6 0 0 0 0.18 +- 0.07 6 5

TIGR03802 (6/6) aspartate-alanine antiporter
TIGR03801 (6/6) aspartate 4-decarboxylase
PF06826 (6/6) Predicted Permease Membrane Region
PF02080 (6/6) TrkA-C domain
PF00155 (6/6) Aminotransferase class I and II
precursor_groups_39609 650.81 +- 12.62 2 0 0 0 0.01 +- 0.01 2 5

PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_groups_2389 15.49 +- 9.40 4 0 0 0 0.20 +- 0.21 4 6

TIGR01488 (4/4) HAD phosphoserine phosphatase-like hydrolase, family IB
PF12710 (4/4) haloacid dehalogenase-like hydrolase
PF01243 (4/4) Pyridoxamine 5'-phosphate oxidase
PF00970 (4/4) Oxidoreductase FAD-binding domain
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00042 (4/4) Globin
precursor_groups_2388 428.41 +- 332.74 6 0 6 0 0.09 +- 0.19 6 26

TIGR01525 (6/6) heavy metal translocating P-type ATPase
TIGR00802 (6/6) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF07690 (6/6) Major Facilitator Superfamily
PF04314 (6/6) Copper chaperone PCu(A)C
PF03824 (6/6) High-affinity nickel-transport protein
PF00702 (6/6) haloacid dehalogenase-like hydrolase
PF00403 (6/6) Heavy-metal-associated domain
PF00122 (6/6) E1-E2 ATPase
TIGR02937 (5/6) RNA polymerase sigma factor, sigma-70 family
PF08281 (5/6) Sigma-70, region 4
PF05118 (5/6) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (5/6) Sigma-70 region 2
TIGR01733 (4/6) amino acid adenylation domain
PF14237 (4/6) GYF domain 2
PF13421 (4/6) SPFH domain-Band 7 family
PF13193 (4/6) AMP-binding enzyme C-terminal domain
PF10862 (4/6) FcoT-like thioesterase domain
PF07993 (4/6) Male sterility protein
PF02668 (4/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (4/6) Condensation domain
PF00550 (4/6) Phosphopantetheine attachment site
PF00501 (4/6) AMP-binding enzyme
TIGR01746 (3/6) thioester reductase domain
PF13738 (3/6) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (3/6) FMN-dependent dehydrogenase
PF00067 (3/6) Cytochrome P450
precursor_groups_47701 45.67 +- 0.55 2 0 0 0 0.18 +- 0.16 2 7

TIGR03718 (2/2) integral membrane protein, TerC family
PF05331 (2/2) Protein of unknown function (DUF742)
PF03741 (2/2) Integral membrane protein TerC family
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_groups_13064 233.43 +- 45.78 7 0 0 0 0.01 +- 0.00 7 9

PF18310 (7/7) Domain of unknown function (DUF5605)
PF17851 (7/7) Beta xylosidase C-terminal Concanavalin A-like domain
PF17390 (7/7) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (7/7) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16586 (7/7) Domain of unknown function (DUF5060)
PF13204 (7/7) Protein of unknown function (DUF4038)
PF08531 (7/7) Alpha-L-rhamnosidase N-terminal domain
PF05592 (7/7) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF04616 (7/7) Glycosyl hydrolases family 43
precursor_groups_13067 75.00 +- 7.07 3 0 1 0 0.05 +- 0.04 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF01039 (3/3) Carboxyl transferase domain
PF00501 (3/3) AMP-binding enzyme
precursor_groups_53196 294.20 +- 221.80 2 0 0 0 0.06 +- 0.20 2 9

PF11723 (2/2) Homotrimeric ring hydroxylase
PF03972 (2/2) MmgE/PrpD family
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF00561 (2/2) alpha/beta hydrolase fold
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_71699 42.93 +- 4.89 2 0 2 0 0.19 +- 0.28 2 13

TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02811 (2/2) PHP domain
PF00817 (2/2) impB/mucB/samB family
PF00741 (2/2) Gas vesicle protein
PF00005 (2/2) ABC transporter
precursor_groups_46540 22.91 +- 1.43 2 0 0 0 0.22 +- 0.23 2 9

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF05853 (2/2) beta-keto acid cleavage enzyme
PF04248 (2/2) Domain of unknown function (DUF427)
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_groups_2944 124.86 +- 71.23 3 0 0 0 0.13 +- 0.25 3 11

PF07859 (3/3) alpha/beta hydrolase fold
PF00296 (3/3) Luciferase-like monooxygenase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF13517 (2/3) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13460 (2/3) NAD(P)H-binding
PF07730 (2/3) Histidine kinase
PF01839 (2/3) FG-GAP repeat
PF01814 (2/3) Hemerythrin HHE cation binding domain
PF00106 (2/3) short chain dehydrogenase
PF00072 (2/3) Response regulator receiver domain
precursor_groups_14462 38.94 +- 0.00 2 0 0 0 0.21 +- 0.36 2 6

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03815 (2/2) helicase/secretion neighborhood CpaE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_35635 499.43 +- 195.48 3 0 0 0 0.01 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_groups_574 641.33 +- 754.54 14 0 13 14 0.04 +- 0.14 14 7

TIGR04364 (14/14) methyltransferase, FxLD system
TIGR04363 (14/14) FxLD family lantipeptide
TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF05147 (14/14) Lanthionine synthetase C-like protein
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF01135 (14/14) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_groups_13665 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_groups_6582 38.95 +- 2.27 3 0 0 0 0.23 +- 0.36 3 6

TIGR03819 (3/3) helicase/secretion neighborhood ATPase
TIGR03815 (3/3) helicase/secretion neighborhood CpaE-like protein
PF14029 (3/3) Protein of unknown function (DUF4244)
PF01656 (3/3) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_groups_47811 2382.31 +- 1144.08 3 0 0 0 0.03 +- 0.10 3 20

TIGR01179 (3/3) UDP-glucose 4-epimerase GalE
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13692 (3/3) Glycosyl transferases group 1
PF13489 (3/3) Methyltransferase domain
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF12708 (3/3) Pectate lyase superfamily protein
PF07883 (3/3) Cupin domain
PF04101 (3/3) Glycosyltransferase family 28 C-terminal domain
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02566 (3/3) OsmC-like protein
PF01979 (3/3) Amidohydrolase family
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00664 (3/3) ABC transporter transmembrane region
PF00155 (3/3) Aminotransferase class I and II
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
PF13641 (2/3) Glycosyltransferase like family 2
PF03704 (2/3) Bacterial transcriptional activator domain
PF00486 (2/3) Transcriptional regulatory protein, C terminal
precursor_groups_35455 21.63 +- 4.99 2 0 0 0 0.23 +- 0.33 2 16

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR01411 (2/2) twin arginine-targeting protein translocase, TatA/E family
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02416 (2/2) mttA/Hcf106 family
PF02342 (2/2) TerD domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01524 (1/2) magnesium-translocating P-type ATPase
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00690 (1/2) Cation transporter/ATPase, N-terminus
PF00689 (1/2) Cation transporting ATPase, C-terminus
PF00122 (1/2) E1-E2 ATPase
precursor_groups_32252 379.18 +- 103.46 3 0 3 0 0.08 +- 0.09 3 29

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (3/3) DJ-1/PfpI family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
precursor_groups_4720 16.13 +- 1.85 7 0 0 0 0.19 +- 0.36 7 7

TIGR01412 (7/7) Tat-translocated enzyme
PF07987 (7/7) Domain of unkown function (DUF1775)
PF05425 (7/7) Copper resistance protein D
PF04314 (7/7) Copper chaperone PCu(A)C
PF04261 (7/7) Dyp-type peroxidase family
PF04234 (7/7) CopC domain
PF02630 (7/7) SCO1/SenC
precursor_groups_84 282.19 +- 380.94 3 0 1 0 0.14 +- 0.23 3 1

PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
precursor_groups_5771 140.66 +- 30.94 2 0 0 0 0.11 +- 0.11 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12802 (2/2) MarR family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_10678 25.88 +- 7.81 5 0 0 0 0.23 +- 0.31 5 14

TIGR01374 (5/5) sarcosine oxidase, delta subunit family
TIGR01373 (5/5) sarcosine oxidase, beta subunit family
TIGR01372 (5/5) sarcosine oxidase, alpha subunit family
PF17806 (5/5) Sarcosine oxidase A3 domain
PF13510 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (5/5) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (5/5) Sarcosine oxidase, gamma subunit family
PF04267 (5/5) Sarcosine oxidase, delta subunit family
PF01571 (5/5) Aminomethyltransferase folate-binding domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00464 (5/5) Serine hydroxymethyltransferase
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF13340 (4/5) Putative transposase of IS4/5 family (DUF4096)
precursor_groups_88 59.97 +- 36.93 8 0 8 0 0.14 +- 0.26 8 3

PF06236 (8/8) Tyrosinase co-factor MelC1
PF03777 (8/8) ChpA-C
PF00264 (8/8) Common central domain of tyrosinase
precursor_groups_66179 323.50 +- 63.50 2 0 0 0 0.02 +- 0.01 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00293 (2/2) NUDIX domain
precursor_groups_31305 291.68 +- 50.47 4 0 3 0 0.04 +- 0.08 4 6

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF07690 (4/4) Major Facilitator Superfamily
PF06241 (4/4) Castor and Pollux, part of voltage-gated ion channel
PF05014 (4/4) Nucleoside 2-deoxyribosyltransferase
PF02633 (4/4) Creatinine amidohydrolase
PF01180 (4/4) Dihydroorotate dehydrogenase
precursor_groups_28337 49.15 +- 26.44 4 0 0 0 0.13 +- 0.11 4 13

TIGR03216 (4/4) 2-hydroxymuconic semialdehyde dehydrogenase
PF04909 (4/4) Amidohydrolase
PF01042 (4/4) Endoribonuclease L-PSP
PF00171 (4/4) Aldehyde dehydrogenase family
TIGR03217 (3/4) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (3/4) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (3/4) 3-hydroxyanthranilate 3,4-dioxygenase
PF09290 (3/4) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (3/4) DmpG-like communication domain
PF06052 (3/4) 3-hydroxyanthranilic acid dioxygenase
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (3/4) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (3/4) HMGL-like
precursor_groups_47384 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_36823 75.27 +- 21.48 2 0 0 0 0.03 +- 0.03 2 2

PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_25212 75.90 +- 32.99 4 0 0 0 0.15 +- 0.23 4 8

TIGR03444 (4/4) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
PF13620 (4/4) Carboxypeptidase regulatory-like domain
PF13088 (4/4) BNR repeat-like domain
PF11695 (4/4) Domain of unknown function (DUF3291)
PF04264 (4/4) YceI-like domain
PF04248 (4/4) Domain of unknown function (DUF427)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF04978 (3/4) Protein of unknown function (DUF664)
precursor_groups_2091 198.66 +- 136.54 4 0 0 0 0.07 +- 0.10 4 2

PF07690 (3/4) Major Facilitator Superfamily
PF00291 (3/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_2090 319.42 +- 251.99 36 0 7 36 0.03 +- 0.03 36 6

TIGR03882 (36/36) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (36/36) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (36/36) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (36/36) Nitroreductase family
PF00664 (36/36) ABC transporter transmembrane region
PF00005 (36/36) ABC transporter
precursor_groups_79365 129.59 +- 16.48 2 0 0 0 0.17 +- 0.16 2 8

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_13115 167.62 +- 107.23 7 0 0 0 0.04 +- 0.12 7 5

PF09587 (7/7) Bacterial capsule synthesis protein PGA_cap
PF08386 (7/7) TAP-like protein
PF00561 (7/7) alpha/beta hydrolase fold
PF00348 (7/7) Polyprenyl synthetase
PF00144 (7/7) Beta-lactamase
precursor_groups_973 1351.25 +- 1281.25 2 0 1 0 0.03 +- 0.05 2 20

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF13649 (1/2) Methyltransferase domain
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF12697 (1/2) Alpha/beta hydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF04073 (1/2) Aminoacyl-tRNA editing domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01551 (1/2) Peptidase family M23
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00931 (1/2) NB-ARC domain
PF00664 (1/2) ABC transporter transmembrane region
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter
precursor_groups_60716 35.50 +- 2.45 2 0 0 0 0.08 +- 0.08 2 5

TIGR01412 (2/2) Tat-translocated enzyme
PF09375 (2/2) Imelysin
PF04261 (2/2) Dyp-type peroxidase family
PF04185 (2/2) Phosphoesterase family
PF14040 (1/2) Deoxyribonuclease NucA/NucB
precursor_groups_47633 84.43 +- 31.07 3 0 3 0 0.18 +- 0.11 3 16

TIGR01085 (3/3) UDP-N-acetylmuramyl-tripeptide synthetase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08245 (3/3) Mur ligase middle domain
PF07690 (3/3) Major Facilitator Superfamily
PF02875 (3/3) Mur ligase family, glutamate ligase domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00005 (3/3) ABC transporter
PF00135 (2/3) Carboxylesterase family
precursor_groups_47144 18.93 +- 8.65 3 0 0 0 0.16 +- 0.10 3 5

PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02515 (3/3) CoA-transferase family III
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00248 (2/3) Aldo/keto reductase family
precursor_groups_13118 28.58 +- 9.95 4 0 2 0 0.10 +- 0.10 4 17

PF01494 (4/4) FAD binding domain
TIGR01733 (2/4) amino acid adenylation domain
PF16197 (2/4) Ketoacyl-synthetase C-terminal extension
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF13160 (2/4) Protein of unknown function (DUF3995)
PF12802 (2/4) MarR family
PF08818 (2/4) Domain of unknown function (DU1801)
PF08713 (2/4) DNA alkylation repair enzyme
PF08659 (2/4) KR domain
PF02801 (2/4) Beta-ketoacyl synthase, C-terminal domain
PF00893 (2/4) Small Multidrug Resistance protein
PF00698 (2/4) Acyl transferase domain
PF00668 (2/4) Condensation domain
PF00583 (2/4) Acetyltransferase (GNAT) family
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00109 (2/4) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_5934 800.42 +- 858.01 3 0 0 0 0.04 +- 0.10 3 9

TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
TIGR03930 (2/3) WXG100 family type VII secretion target
PF06259 (2/3) Alpha/beta hydrolase
PF06013 (2/3) Proteins of 100 residues with WXG
precursor_groups_75204 54.17 +- 0.00 2 0 0 0 0.11 +- 0.21 2 6

TIGR01806 (2/2) putative chorismate mutase
PF13808 (2/2) DDE_Tnp_1-associated
PF07730 (2/2) Histidine kinase
PF01817 (2/2) Chorismate mutase type II
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_24637 1427.00 +- 223.49 4 0 0 0 0.01 +- 0.00 4 7

PF13480 (4/4) Acetyltransferase (GNAT) domain
PF08892 (4/4) YqcI/YcgG family
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01725 (4/4) Ham1 family
PF00590 (4/4) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_24635 36.88 +- 3.03 4 0 4 0 0.08 +- 0.01 4 3

PF00550 (4/4) Phosphopantetheine attachment site
PF00268 (4/4) Ribonucleotide reductase, small chain
PF00067 (4/4) Cytochrome P450
precursor_groups_888 181.75 +- 45.66 5 0 1 0 0.06 +- 0.08 5 14

PF18565 (3/5) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/5) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/5) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/5) Domain of unknown function (DUF4982)
PF14310 (3/5) Fibronectin type III-like domain
PF13561 (3/5) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/5) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/5) alpha/beta hydrolase fold
PF05592 (3/5) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/5) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/5) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/5) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/5) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/5) Glycosyl hydrolases family 2
precursor_groups_28226 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_groups_15889 174.02 +- 106.46 3 0 0 0 0.03 +- 0.05 3 4

PF07702 (3/3) UTRA domain
PF07690 (3/3) Major Facilitator Superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00293 (3/3) NUDIX domain
precursor_groups_5527 820.61 +- 469.39 2 0 1 2 0.03 +- 0.05 2 6

PF13471 (2/2) Transglutaminase-like superfamily
PF00400 (2/2) WD domain, G-beta repeat
PF00326 (2/2) Prolyl oligopeptidase family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
precursor_groups_76703 17.08 +- 2.28 2 0 0 0 0.12 +- 0.07 2 5

PF14361 (2/2) RsbT co-antagonist protein rsbRD N-terminal domain
PF12802 (2/2) MarR family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (2/2) STAS domain
precursor_groups_5520 13.47 +- 0.47 2 0 0 0 0.15 +- 0.03 2 2

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
precursor_groups_35633 553.90 +- 184.40 3 0 0 0 0.03 +- 0.02 3 12

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12833 (3/3) Helix-turn-helix domain
PF12625 (3/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06821 (3/3) Serine hydrolase
PF05853 (3/3) beta-keto acid cleavage enzyme
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (3/3) AMP-binding enzyme
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_42513 214.79 +- 38.91 3 0 3 0 0.03 +- 0.02 3 13

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00296 (3/3) Luciferase-like monooxygenase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
jaccard_groups_434 162.75 +- 168.08 7 0 5 0 0.09 +- 0.23 7 3

PF17837 (7/7) 4'-phosphopantetheinyl transferase N-terminal domain
PF01648 (7/7) 4'-phosphopantetheinyl transferase superfamily
PF00149 (4/7) Calcineurin-like phosphoesterase
jaccard_groups_437 759.74 +- 798.42 9 0 2 0 0.04 +- 0.15 9 10

PF02515 (9/9) CoA-transferase family III
PF02771 (8/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (8/9) Acyl-CoA dehydrogenase, middle domain
PF00441 (8/9) Acyl-CoA dehydrogenase, C-terminal domain
PF02737 (7/9) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (7/9) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
TIGR01930 (5/9) acetyl-CoA C-acyltransferase
PF02803 (5/9) Thiolase, C-terminal domain
PF00378 (5/9) Enoyl-CoA hydratase/isomerase
PF00108 (5/9) Thiolase, N-terminal domain
jaccard_groups_433 36.45 +- 6.10 2 0 0 0 0.14 +- 0.14 2 9

PF05621 (2/2) Bacterial TniB protein
PF00665 (2/2) Integrase core domain
PF13646 (1/2) HEAT repeats
PF13411 (1/2) MerR HTH family regulatory protein
PF09299 (1/2) Mu transposase, C-terminal
PF06527 (1/2) TniQ
PF04851 (1/2) Type III restriction enzyme, res subunit
PF03457 (1/2) Helicase associated domain
PF01636 (1/2) Phosphotransferase enzyme family
jaccard_groups_1933 509.31 +- 204.38 18 0 17 18 0.02 +- 0.04 18 10

PF04303 (18/18) PrpF protein
PF02771 (18/18) Acyl-CoA dehydrogenase, N-terminal domain
PF00441 (18/18) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (17/18) Acyl-CoA dehydrogenase, middle domain
TIGR01536 (16/18) asparagine synthase (glutamine-hydrolyzing)
PF13537 (16/18) Glutamine amidotransferase domain
PF01979 (16/18) Amidohydrolase family
PF00733 (16/18) Asparagine synthase
TIGR00857 (11/18) dihydroorotase, multifunctional complex type
PF07690 (10/18) Major Facilitator Superfamily
jaccard_groups_2058 95.56 +- 34.97 11 0 8 0 0.04 +- 0.04 11 3

PF00106 (11/11) short chain dehydrogenase
PF00248 (10/11) Aldo/keto reductase family
PF01965 (9/11) DJ-1/PfpI family
jaccard_groups_3051 155.88 +- 59.12 2 0 2 0 0.05 +- 0.05 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01136 (2/2) cysteine synthase
PF00975 (2/2) Thioesterase domain
PF00892 (2/2) EamA-like transporter family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF14027 (1/2) Questin oxidase-like
PF12833 (1/2) Helix-turn-helix domain
PF11814 (1/2) Peptidase_C39 like family
PF07883 (1/2) Cupin domain
PF02311 (1/2) AraC-like ligand binding domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00005 (1/2) ABC transporter
jaccard_groups_6008 43.69 +- 3.22 2 0 0 0 0.09 +- 0.08 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
PF00083 (2/2) Sugar (and other) transporter
jaccard_groups_3505 304.86 +- 85.14 2 0 1 0 0.04 +- 0.11 2 8

TIGR04267 (2/2) HEXXH motif domain
PF07690 (2/2) Major Facilitator Superfamily
PF01613 (2/2) Flavin reductase like domain
PF01432 (2/2) Peptidase family M3
PF14559 (1/2) Tetratricopeptide repeat
PF03621 (1/2) MbtH-like protein
PF00975 (1/2) Thioesterase domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_3056 458.75 +- 199.75 3 0 0 0 0.01 +- 0.01 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF01638 (3/3) HxlR-like helix-turn-helix
TIGR00654 (2/3) phenazine biosynthesis protein, PhzF family
PF13673 (2/3) Acetyltransferase (GNAT) domain
PF13649 (2/3) Methyltransferase domain
PF02567 (2/3) Phenazine biosynthesis-like protein
jaccard_groups_2050 67.94 +- 80.05 6 0 6 0 0.13 +- 0.21 6 3

PF08241 (6/6) Methyltransferase domain
PF00348 (6/6) Polyprenyl synthetase
PF13424 (4/6) Tetratricopeptide repeat
jaccard_groups_3508 23.42 +- 4.66 4 0 0 0 0.16 +- 0.25 4 4

PF07690 (4/4) Major Facilitator Superfamily
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
PF00149 (4/4) Calcineurin-like phosphoesterase
PF00135 (3/4) Carboxylesterase family
jaccard_groups_6001 174.11 +- 32.29 2 0 0 2 0.02 +- 0.03 2 6

PF13023 (2/2) HD domain
PF12671 (2/2) Putative amidase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF01634 (2/2) ATP phosphoribosyltransferase
jaccard_groups_6007 644.06 +- 387.94 2 0 2 0 0.04 +- 0.14 2 26

TIGR03081 (2/2) methylmalonyl-CoA epimerase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01194 (2/2) cyclic peptide transporter
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (2/2) ParB-like nuclease domain
PF01804 (2/2) Penicillin amidase
PF01066 (2/2) CDP-alcohol phosphatidyltransferase
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
jaccard_groups_2057 75.84 +- 44.04 17 0 1 0 0.07 +- 0.05 17 6

TIGR04538 (17/17) cytochrome P450, cyclodipeptide synthase-associated
PF09339 (17/17) IclR helix-turn-helix domain
PF03055 (17/17) Retinal pigment epithelial membrane protein
PF01614 (17/17) Bacterial transcriptional regulator
PF00067 (17/17) Cytochrome P450
PF12680 (10/17) SnoaL-like domain
jaccard_groups_2124 68.58 +- 37.00 4 0 0 0 0.05 +- 0.03 4 3

PF13520 (4/4) Amino acid permease
PF00202 (4/4) Aminotransferase class-III
PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_2125 40.10 +- 25.66 2 0 0 0 0.20 +- 0.15 2 12

PF07705 (2/2) CARDB
PF05922 (2/2) Peptidase inhibitor I9
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00082 (2/2) Subtilase family
TIGR01451 (1/2) conserved repeat domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF08533 (1/2) Beta-galactosidase C-terminal domain
PF08532 (1/2) Beta-galactosidase trimerisation domain
PF02449 (1/2) Beta-galactosidase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_2120 440.86 +- 251.20 7 0 7 3 0.03 +- 0.02 7 5

PF07993 (7/7) Male sterility protein
PF03756 (7/7) A-factor biosynthesis hotdog domain
PF01326 (7/7) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (7/7) PEP-utilising enzyme, mobile domain
PF00334 (7/7) Nucleoside diphosphate kinase
jaccard_groups_2122 155.44 +- 172.97 9 0 1 0 0.10 +- 0.12 9 10

PF18448 (9/9) Carbohydrate binding domain
PF03442 (9/9) Carbohydrate binding domain X2
PF00150 (9/9) Cellulase (glycosyl hydrolase family 5)
PF17851 (8/9) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (8/9) Glycosyl hydrolases family 43
PF02065 (7/9) Melibiase
PF13377 (6/9) Periplasmic binding protein-like domain
PF02449 (6/9) Beta-galactosidase
PF00356 (6/9) Bacterial regulatory proteins, lacI family
PF08532 (5/9) Beta-galactosidase trimerisation domain
jaccard_groups_3186 59.28 +- 33.63 7 0 7 0 0.08 +- 0.14 7 4

PF07690 (7/7) Major Facilitator Superfamily
PF00266 (7/7) Aminotransferase class-V
PF00171 (7/7) Aldehyde dehydrogenase family
PF00905 (4/7) Penicillin binding protein transpeptidase domain
jaccard_groups_2907 319.14 +- 204.62 9 0 0 0 0.04 +- 0.13 9 7

PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (9/9) AMP-binding enzyme
PF00171 (9/9) Aldehyde dehydrogenase family
PF16859 (7/9) Tetracyclin repressor-like, C-terminal domain
PF07690 (7/9) Major Facilitator Superfamily
PF00440 (7/9) Bacterial regulatory proteins, tetR family
jaccard_groups_2904 79.19 +- 52.54 9 0 0 0 0.17 +- 0.32 9 18

PF17863 (9/9) AAA lid domain
PF13519 (9/9) von Willebrand factor type A domain
PF13365 (9/9) Trypsin-like peptidase domain
PF07726 (9/9) ATPase family associated with various cellular activities (AAA)
PF07584 (9/9) Aerotolerance regulator N-terminal
PF02518 (9/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01882 (9/9) Protein of unknown function DUF58
PF00672 (9/9) HAMP domain
PF00512 (9/9) His Kinase A (phospho-acceptor) domain
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00072 (9/9) Response regulator receiver domain
TIGR00838 (8/9) argininosuccinate lyase
TIGR00785 (8/9) transporter, divalent anion:Na+ symporter (DASS) family
TIGR00032 (8/9) argininosuccinate synthase
PF14698 (8/9) Argininosuccinate lyase C-terminal
PF00939 (8/9) Sodium:sulfate symporter transmembrane region
PF00764 (8/9) Arginosuccinate synthase
PF00206 (8/9) Lyase
jaccard_groups_6484 80.95 +- 7.19 2 0 0 0 0.12 +- 0.08 2 9

TIGR00052 (2/2) nudix-type nucleoside diphosphatase, YffH/AdpP family
PF17912 (2/2) MalK OB fold domain
PF04248 (2/2) Domain of unknown function (DUF427)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01230 (2/2) HIT domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00293 (2/2) NUDIX domain
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
jaccard_groups_6480 142.58 +- 0.76 2 0 2 2 0.01 +- 0.01 2 3

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase
PF00293 (2/2) NUDIX domain
jaccard_groups_2908 107.64 +- 9.63 2 0 2 0 0.09 +- 0.23 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13424 (2/2) Tetratricopeptide repeat
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12770 (2/2) CHAT domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07681 (2/2) DoxX
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13808 (1/2) DDE_Tnp_1-associated
PF13545 (1/2) Crp-like helix-turn-helix domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01609 (1/2) Transposase DDE domain
jaccard_groups_2909 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3611 174.45 +- 52.72 5 0 5 0 0.06 +- 0.12 5 25

TIGR01762 (5/5) chlorinating enzyme
TIGR01733 (5/5) amino acid adenylation domain
TIGR01444 (5/5) methyltransferase, FkbM family
TIGR00843 (5/5) benzoate transporter
PF16990 (5/5) Carbohydrate binding module (family 35)
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07691 (5/5) PA14 domain
PF06439 (5/5) Domain of Unknown Function (DUF1080)
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (5/5) Methyltransferase FkbM domain
PF03594 (5/5) Benzoate membrane transport protein
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01509 (4/5) HAD hydrolase, family IA, variant 3
PF13560 (4/5) Helix-turn-helix domain
PF13535 (4/5) ATP-grasp domain
PF13454 (4/5) FAD-NAD(P)-binding
PF13419 (4/5) Haloacid dehalogenase-like hydrolase
PF04149 (4/5) Domain of unknown function (DUF397)
PF01116 (4/5) Fructose-bisphosphate aldolase class-II
PF00892 (4/5) EamA-like transporter family
jaccard_groups_1541 47.60 +- 97.92 10 0 3 0 0.13 +- 0.09 10 5

PF12769 (10/10) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (10/10) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (10/10) NAD(P) transhydrogenase beta subunit
PF01262 (10/10) Alanine dehydrogenase/PNT, C-terminal domain
TIGR00561 (9/10) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
jaccard_groups_3613 556.36 +- 312.83 6 0 0 0 0.03 +- 0.10 6 7

PF13185 (6/6) GAF domain
PF12833 (6/6) Helix-turn-helix domain
PF09056 (6/6) Prokaryotic phospholipase A2
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF01965 (6/6) DJ-1/PfpI family
PF01483 (6/6) Proprotein convertase P-domain
PF00082 (6/6) Subtilase family
jaccard_groups_3619 115.24 +- 34.84 5 0 0 0 0.07 +- 0.07 5 8

TIGR01484 (5/5) HAD hydrolase, family IIB
PF13309 (5/5) HTH domain
PF08348 (5/5) YheO-like PAS domain
PF08282 (5/5) haloacid dehalogenase-like hydrolase
PF04655 (5/5) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04075 (5/5) F420H(2)-dependent quinone reductase
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
jaccard_groups_1019 239.94 +- 108.00 5 0 2 0 0.02 +- 0.01 5 3

PF16884 (5/5) N-terminal domain of oxidoreductase
PF00107 (5/5) Zinc-binding dehydrogenase
PF13411 (3/5) MerR HTH family regulatory protein
jaccard_groups_5479 396.06 +- 136.06 2 0 0 0 0.02 +- 0.02 2 9

TIGR00784 (2/2) citrate transporter
PF17874 (2/2) MalT-like TPR region
PF13649 (2/2) Methyltransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03600 (2/2) Citrate transporter
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
jaccard_groups_5478 334.90 +- 12.40 2 0 0 0 0.01 +- 0.02 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01241 (2/2) ATP-dependent metallopeptidase HflB
TIGR00374 (2/2) TIGR00374 family protein
PF17862 (2/2) AAA+ lid domain
PF13649 (2/2) Methyltransferase domain
PF13473 (2/2) Cupredoxin-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06480 (2/2) FtsH Extracellular
PF04945 (2/2) YHS domain
PF03706 (2/2) Lysylphosphatidylglycerol synthase TM region
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01434 (2/2) Peptidase family M41
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00122 (2/2) E1-E2 ATPase
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
jaccard_groups_5476 518.00 +- 2.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR00013 (2/2) 4-oxalocrotonate tautomerase family enzyme
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF03928 (2/2) Haem-degrading
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01361 (2/2) Tautomerase enzyme
jaccard_groups_6399 1660.13 +- 204.13 2 0 1 0 0.01 +- 0.00 2 21

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
PF13580 (2/2) SIS domain
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12708 (2/2) Pectate lyase superfamily protein
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00923 (2/2) Transaldolase/Fructose-6-phosphate aldolase
PF00754 (2/2) F5/8 type C domain
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
PF15780 (1/2) Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF07610 (1/2) Protein of unknown function (DUF1573)
PF02894 (1/2) Oxidoreductase family, C-terminal alpha/beta domain
jaccard_groups_6398 877.16 +- 799.84 2 0 2 0 0.09 +- 0.25 2 21

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF16864 (2/2) Dimerisation domain
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13649 (2/2) Methyltransferase domain
PF07883 (2/2) Cupin domain
PF04199 (2/2) Putative cyclase
PF04191 (2/2) Phospholipid methyltransferase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00891 (2/2) O-methyltransferase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00294 (2/2) pfkB family carbohydrate kinase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01034 (1/2) methionine adenosyltransferase
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF02773 (1/2) S-adenosylmethionine synthetase, C-terminal domain
PF02772 (1/2) S-adenosylmethionine synthetase, central domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00438 (1/2) S-adenosylmethionine synthetase, N-terminal domain
jaccard_groups_2698 343.55 +- 215.75 5 0 1 0 0.05 +- 0.06 5 6

PF09339 (5/5) IclR helix-turn-helix domain
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF01614 (5/5) Bacterial transcriptional regulator
PF00107 (5/5) Zinc-binding dehydrogenase
PF07690 (3/5) Major Facilitator Superfamily
PF02515 (3/5) CoA-transferase family III
jaccard_groups_6391 204.23 +- 0.06 2 0 0 2 0.10 +- 0.29 2 11

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR01343 (2/2) homoaconitate hydratase family protein
TIGR00049 (2/2) iron-sulfur cluster assembly accessory protein
PF08241 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF01521 (2/2) Iron-sulphur cluster biosynthesis
PF01106 (2/2) NifU-like domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_2876 895.56 +- 418.89 2 0 2 1 0.02 +- 0.02 2 20

TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF06500 (2/2) Alpha/beta hydrolase of unknown function (DUF1100)
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14079 (1/2) Domain of unknown function (DUF4260)
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (1/2) Thioesterase domain
PF00198 (1/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF00067 (1/2) Cytochrome P450
jaccard_groups_2693 188.86 +- 134.12 6 0 0 0 0.03 +- 0.04 6 5

TIGR00218 (6/6) mannose-6-phosphate isomerase, class I
PF01238 (6/6) Phosphomannose isomerase type I
PF00480 (6/6) ROK family
PF00150 (6/6) Cellulase (glycosyl hydrolase family 5)
PF00553 (5/6) Cellulose binding domain
jaccard_groups_6395 391.02 +- 19.50 2 0 1 0 0.03 +- 0.04 2 8

PF12698 (2/2) ABC-2 family transporter protein
PF11666 (2/2) Protein of unknown function (DUF2933)
PF04191 (2/2) Phospholipid methyltransferase
PF00005 (2/2) ABC transporter
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF03771 (1/2) Domain of unknown function (DUF317)
PF03713 (1/2) Domain of unknown function (DUF305)
PF00690 (1/2) Cation transporter/ATPase, N-terminus
jaccard_groups_2691 119.15 +- 98.95 6 0 5 0 0.06 +- 0.12 6 6

PF13243 (6/6) Squalene-hopene cyclase C-terminal domain
PF00432 (6/6) Prenyltransferase and squalene oxidase repeat
PF00754 (4/6) F5/8 type C domain
PF00067 (4/6) Cytochrome P450
TIGR03356 (3/6) beta-galactosidase
PF00232 (3/6) Glycosyl hydrolase family 1
jaccard_groups_721 163.73 +- 80.57 3 0 1 0 0.02 +- 0.03 3 1

PF01596 (3/3) O-methyltransferase
jaccard_groups_725 194.97 +- 130.40 23 0 1 0 0.06 +- 0.10 23 7

PF12696 (23/23) TraM recognition site of TraD and TraG
PF03771 (23/23) Domain of unknown function (DUF317)
PF00772 (20/23) DnaB-like helicase N terminal domain
PF00145 (20/23) C-5 cytosine-specific DNA methylase
PF00535 (18/23) Glycosyl transferase family 2
PF07728 (16/23) AAA domain (dynein-related subfamily)
PF07690 (16/23) Major Facilitator Superfamily
jaccard_groups_5878 269.54 +- 250.46 2 0 0 0 0.11 +- 0.27 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00481 (2/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF07690 (2/2) Major Facilitator Superfamily
PF01161 (2/2) Phosphatidylethanolamine-binding protein
PF00857 (2/2) Isochorismatase family
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_893 27.23 +- 17.49 5 0 0 0 0.13 +- 0.16 5 3

TIGR00099 (5/5) Cof-like hydrolase
PF08282 (5/5) haloacid dehalogenase-like hydrolase
PF09335 (3/5) SNARE associated Golgi protein
jaccard_groups_892 112.48 +- 61.30 11 0 1 11 0.24 +- 0.07 11 34

TIGR03026 (11/11) nucleotide sugar dehydrogenase
TIGR01536 (11/11) asparagine synthase (glutamine-hydrolyzing)
PF16889 (11/11) Heparinase II/III N-terminus
PF16254 (11/11) Domain of unknown function (DUF4910)
PF16221 (11/11) winged helix-turn-helix
PF13692 (11/11) Glycosyl transferases group 1
PF13579 (11/11) Glycosyl transferase 4-like domain
PF13537 (11/11) Glutamine amidotransferase domain
PF13489 (11/11) Methyltransferase domain
PF13439 (11/11) Glycosyltransferase Family 4
PF08484 (11/11) C-methyltransferase C-terminal domain
PF08421 (11/11) Putative zinc binding domain
PF07940 (11/11) Heparinase II/III-like protein
PF04230 (11/11) Polysaccharide pyruvyl transferase
PF03721 (11/11) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (11/11) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (11/11) Chain length determinant protein
PF02585 (11/11) GlcNAc-PI de-N-acetylase
PF01408 (11/11) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (11/11) NAD dependent epimerase/dehydratase family
PF00984 (11/11) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00908 (11/11) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (11/11) Asparagine synthase
PF00535 (11/11) Glycosyl transferase family 2
PF00202 (11/11) Aminotransferase class-III
PF00107 (11/11) Zinc-binding dehydrogenase
PF13229 (10/11) Right handed beta helix region
PF00534 (10/11) Glycosyl transferases group 1
TIGR03025 (9/11) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (9/11) CoA-binding domain
PF02397 (9/11) Bacterial sugar transferase
PF13857 (6/11) Ankyrin repeats (many copies)
PF06628 (6/11) Catalase-related immune-responsive
PF00199 (6/11) Catalase
jaccard_groups_2672 155.71 +- 90.45 10 0 4 0 0.17 +- 0.26 10 11

PF11975 (10/10) Family 4 glycosyl hydrolase C-terminal domain
PF08376 (10/10) Nitrate and nitrite sensing
PF07690 (10/10) Major Facilitator Superfamily
PF05331 (10/10) Protein of unknown function (DUF742)
PF03259 (10/10) Roadblock/LC7 domain
PF02518 (10/10) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02056 (10/10) Family 4 glycosyl hydrolase
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00294 (10/10) pfkB family carbohydrate kinase
PF03537 (8/10) Glycoside-hydrolase family GH114
jaccard_groups_2673 126.46 +- 93.03 3 0 0 0 0.04 +- 0.03 3 9

TIGR01494 (3/3) HAD ATPase, P-type, family IC
PF00689 (3/3) Cation transporting ATPase, C-terminus
PF13246 (2/3) Cation transport ATPase (P-type)
PF02254 (2/3) TrkA-N domain
PF02080 (2/3) TrkA-C domain
PF00702 (2/3) haloacid dehalogenase-like hydrolase
PF00690 (2/3) Cation transporter/ATPase, N-terminus
PF00582 (2/3) Universal stress protein family
PF00122 (2/3) E1-E2 ATPase
jaccard_groups_2674 114.33 +- 17.12 5 0 0 0 0.11 +- 0.06 5 10

TIGR01382 (5/5) intracellular protease, PfpI family
PF13823 (5/5) Alcohol dehydrogenase GroES-associated
PF09123 (5/5) Domain of unknown function (DUF1931)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF01965 (5/5) DJ-1/PfpI family
PF00248 (5/5) Aldo/keto reductase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF13515 (4/5) Fusaric acid resistance protein-like
PF12805 (4/5) FUSC-like inner membrane protein yccS
jaccard_groups_2675 63.37 +- 64.63 11 0 1 0 0.14 +- 0.17 11 6

PF04016 (11/11) Putative heavy-metal chelation
PF01497 (11/11) Periplasmic binding protein
PF01032 (11/11) FecCD transport family
PF00291 (11/11) Pyridoxal-phosphate dependent enzyme
PF00005 (11/11) ABC transporter
PF00288 (7/11) GHMP kinases N terminal domain
jaccard_groups_2676 250.41 +- 104.95 11 0 11 11 0.05 +- 0.03 11 13

TIGR04451 (11/11) lantipeptide, SCO0268 family
TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF12697 (11/11) Alpha/beta hydrolase family
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF12802 (9/11) MarR family
PF02065 (9/11) Melibiase
PF01547 (9/11) Bacterial extracellular solute-binding protein
PF00480 (9/11) ROK family
PF02894 (8/11) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/11) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_894 20.86 +- 2.59 3 0 0 0 0.14 +- 0.09 3 5

PF13802 (3/3) Galactose mutarotase-like
PF01055 (3/3) Glycosyl hydrolases family 31
TIGR00369 (2/3) uncharacterized domain 1
PF17137 (2/3) Domain of unknown function (DUF5110)
PF03061 (2/3) Thioesterase superfamily
jaccard_groups_5586 252.33 +- 137.67 2 0 0 0 0.02 +- 0.04 2 4

PF04203 (2/2) Sortase domain
PF01590 (2/2) GAF domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_5585 1750.00 +- 450.00 2 0 2 0 0.01 +- 0.00 2 13

TIGR02320 (2/2) phosphoenolpyruvate mutase
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01566 (2/2) Natural resistance-associated macrophage protein
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00202 (2/2) Aminotransferase class-III
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_5583 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
jaccard_groups_2474 208.79 +- 64.06 5 0 0 0 0.02 +- 0.01 5 4

PF13454 (5/5) FAD-NAD(P)-binding
PF07969 (5/5) Amidohydrolase family
PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
jaccard_groups_2472 1598.11 +- 1158.50 12 0 1 11 0.02 +- 0.03 12 25

PF17755 (12/12) UvrA DNA-binding domain
PF16169 (12/12) Domain of unknown function (DUF4872)
PF14399 (12/12) Butirosin biosynthesis protein H, N-terminal
PF13370 (12/12) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (12/12) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08241 (12/12) Methyltransferase domain
PF04879 (12/12) Molybdopterin oxidoreductase Fe4S4 domain
PF03241 (12/12) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (12/12) Flavin reductase like domain
PF01568 (12/12) Molydopterin dinucleotide binding domain
PF00795 (12/12) Carbon-nitrogen hydrolase
PF00384 (12/12) Molybdopterin oxidoreductase
PF00291 (12/12) Pyridoxal-phosphate dependent enzyme
PF00005 (12/12) ABC transporter
TIGR03812 (11/12) tyrosine decarboxylase MnfA
PF04055 (11/12) Radical SAM superfamily
PF02310 (11/12) B12 binding domain
PF02195 (11/12) ParB-like nuclease domain
PF01061 (11/12) ABC-2 type transporter
PF00805 (11/12) Pentapeptide repeats (8 copies)
PF00282 (11/12) Pyridoxal-dependent decarboxylase conserved domain
PF16861 (10/12) Carbamoyltransferase C-terminus
PF08713 (10/12) DNA alkylation repair enzyme
PF02543 (10/12) Carbamoyltransferase N-terminus
PF00501 (10/12) AMP-binding enzyme
jaccard_groups_5613 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_643 36.15 +- 44.06 5 0 0 0 0.11 +- 0.11 5 2

PF07995 (5/5) Glucose / Sorbosone dehydrogenase
PF00174 (4/5) Oxidoreductase molybdopterin binding domain
jaccard_groups_5278 678.69 +- 611.31 2 0 0 0 0.08 +- 0.25 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00480 (2/2) ROK family
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
jaccard_groups_2587 33.13 +- 10.10 3 0 0 0 0.10 +- 0.16 3 6

PF14534 (3/3) Domain of unknown function (DUF4440)
PF07690 (3/3) Major Facilitator Superfamily
PF00962 (3/3) Adenosine/AMP deaminase
TIGR03567 (2/3) FMN reductase
PF03358 (2/3) NADPH-dependent FMN reductase
PF00720 (2/3) Subtilisin inhibitor-like
jaccard_groups_2584 168.70 +- 91.30 2 0 0 0 0.03 +- 0.04 2 4

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_2585 214.44 +- 200.20 2 0 0 0 0.12 +- 0.23 2 6

PF06094 (2/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF03358 (2/2) NADPH-dependent FMN reductase
PF03091 (2/2) CutA1 divalent ion tolerance protein
PF00005 (2/2) ABC transporter
PF03995 (1/2) Peptidase inhibitor family I36
PF00664 (1/2) ABC transporter transmembrane region
jaccard_groups_5270 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
jaccard_groups_2588 247.75 +- 142.25 2 0 0 0 0.07 +- 0.20 2 9

PF13692 (2/2) Glycosyl transferases group 1
PF01636 (2/2) Phosphotransferase enzyme family
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00293 (2/2) NUDIX domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13560 (1/2) Helix-turn-helix domain
PF13439 (1/2) Glycosyltransferase Family 4
PF04149 (1/2) Domain of unknown function (DUF397)
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_5293 466.40 +- 53.60 2 0 0 0 0.01 +- 0.00 2 4

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_6177 551.25 +- 228.75 2 0 0 0 0.03 +- 0.07 2 15

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF04444 (2/2) Catechol dioxygenase N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00501 (2/2) AMP-binding enzyme
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00041 (2/2) Fibronectin type III domain
jaccard_groups_5291 340.69 +- 179.31 2 0 1 0 0.03 +- 0.02 2 11

PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF01979 (2/2) Amidohydrolase family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
TIGR00193 (1/2) urease, gamma subunit
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_5299 120.05 +- 21.77 2 0 1 0 0.13 +- 0.23 2 15

PF16347 (2/2) Domain of unknown function (DUF4976)
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF01229 (2/2) Glycosyl hydrolases family 39
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR02891 (1/2) cytochrome c oxidase, subunit I
PF13631 (1/2) Cytochrome b(N-terminal)/b6/petB
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12270 (1/2) Cytochrome c oxidase subunit IV
PF01301 (1/2) Glycosyl hydrolases family 35
PF00115 (1/2) Cytochrome C and Quinol oxidase polypeptide I
jaccard_groups_5053 126.71 +- 45.68 3 0 0 0 0.06 +- 0.07 3 13

TIGR00778 (3/3) alkylhydroperoxidase AhpD family core domain
TIGR00566 (3/3) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (3/3) aminodeoxychorismate synthase, component I
PF12876 (3/3) Sugar-binding cellulase-like
PF08962 (3/3) Domain of unknown function (DUF1876)
PF07690 (3/3) Major Facilitator Superfamily
PF04715 (3/3) Anthranilate synthase component I, N terminal region
PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01063 (3/3) Amino-transferase class IV
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF00083 (3/3) Sugar (and other) transporter
jaccard_groups_5052 22.78 +- 1.41 2 0 2 0 0.20 +- 0.14 2 12

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_5054 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
jaccard_groups_5057 158.01 +- 35.35 3 0 0 1 0.06 +- 0.07 3 9

PF13671 (3/3) AAA domain
PF13649 (3/3) Methyltransferase domain
PF09364 (3/3) XFP N-terminal domain
PF09363 (3/3) XFP C-terminal domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (3/3) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01427 (3/3) D-ala-D-ala dipeptidase
PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
jaccard_groups_5724 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_5058 225.74 +- 164.26 2 0 2 0 0.05 +- 0.05 2 8

PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF13483 (2/2) Beta-lactamase superfamily domain
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF14696 (1/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_5728 28.73 +- 9.97 2 0 0 0 0.07 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00455 (2/2) DeoR C terminal sensor domain
jaccard_groups_941 80.86 +- 120.15 19 0 0 0 0.10 +- 0.09 19 4

PF08244 (19/19) Glycosyl hydrolases family 32 C terminal
PF00294 (19/19) pfkB family carbohydrate kinase
PF00251 (19/19) Glycosyl hydrolases family 32 N-terminal domain
PF03992 (18/19) Antibiotic biosynthesis monooxygenase
jaccard_groups_947 43.09 +- 82.01 8 0 0 0 0.20 +- 0.19 8 3

PF03471 (8/8) Transporter associated domain
PF01595 (8/8) Cyclin M transmembrane N-terminal domain
PF00571 (8/8) CBS domain
jaccard_groups_946 167.80 +- 193.98 37 0 11 3 0.09 +- 0.11 37 5

PF18603 (37/37) L-amino acid ligase C-terminal domain 2
PF13535 (37/37) ATP-grasp domain
PF07690 (33/37) Major Facilitator Superfamily
PF00291 (31/37) Pyridoxal-phosphate dependent enzyme
PF13649 (22/37) Methyltransferase domain
jaccard_groups_949 361.33 +- 218.73 3 0 1 0 0.02 +- 0.03 3 1

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
jaccard_groups_948 1919.75 +- 1536.95 81 0 62 53 0.03 +- 0.09 81 9

PF00465 (81/81) Iron-containing alcohol dehydrogenase
PF00202 (81/81) Aminotransferase class-III
PF00005 (81/81) ABC transporter
PF13649 (80/81) Methyltransferase domain
PF00296 (76/81) Luciferase-like monooxygenase
PF00069 (72/81) Protein kinase domain
PF05147 (47/81) Lanthionine synthetase C-like protein
PF00535 (46/81) Glycosyl transferase family 2
PF00483 (42/81) Nucleotidyl transferase
jaccard_groups_1374 130.91 +- 98.98 6 0 5 0 0.03 +- 0.04 6 3

PF00550 (6/6) Phosphopantetheine attachment site
TIGR02353 (4/6) non-ribosomal peptide synthetase terminal domain of unknown function
PF00583 (3/6) Acetyltransferase (GNAT) family
jaccard_groups_1375 35.88 +- 7.87 8 0 8 0 0.18 +- 0.14 8 9

TIGR00543 (8/8) isochorismate synthase
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF00857 (8/8) Isochorismatase family
PF00501 (8/8) AMP-binding enzyme
PF00425 (8/8) chorismate binding enzyme
TIGR04316 (7/8) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
TIGR02275 (7/8) (2,3-dihydroxybenzoyl)adenylate synthase
PF00550 (7/8) Phosphopantetheine attachment site
jaccard_groups_1376 259.32 +- 156.71 7 0 1 7 0.05 +- 0.17 7 14

TIGR03969 (7/7) mycofactocin precursor
TIGR03967 (7/7) putative mycofactocin binding protein MftB
TIGR03966 (7/7) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (7/7) mycofactocin system glycosyltransferase
TIGR03964 (7/7) mycofactocin system creatininase family protein
TIGR03962 (7/7) mycofactocin radical SAM maturase
PF04055 (7/7) Radical SAM superfamily
PF02633 (7/7) Creatinine amidohydrolase
PF01070 (7/7) FMN-dependent dehydrogenase
PF13561 (5/7) Enoyl-(Acyl carrier protein) reductase
PF00535 (5/7) Glycosyl transferase family 2
TIGR04504 (4/7) SDR family mycofactocin-dependent oxidoreductase
PF13632 (4/7) Glycosyl transferase family group 2
PF13186 (4/7) Iron-sulfur cluster-binding domain
jaccard_groups_1377 19.26 +- 0.00 2 0 0 0 0.10 +- 0.09 2 5

TIGR01085 (2/2) UDP-N-acetylmuramyl-tripeptide synthetase
PF08245 (2/2) Mur ligase middle domain
PF02875 (2/2) Mur ligase family, glutamate ligase domain
PF01225 (2/2) Mur ligase family, catalytic domain
PF00135 (2/2) Carboxylesterase family
jaccard_groups_5120 18.80 +- 4.95 3 0 0 0 0.11 +- 0.12 3 5

PF13489 (3/3) Methyltransferase domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
PF00204 (3/3) DNA gyrase B
jaccard_groups_5123 51.21 +- 6.05 3 0 0 0 0.08 +- 0.07 3 5

PF13649 (3/3) Methyltransferase domain
PF11706 (3/3) CGNR zinc finger
PF08445 (3/3) FR47-like protein
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07336 (3/3) Putative stress-induced transcription regulator
jaccard_groups_5021 206.04 +- 127.96 3 0 3 2 0.03 +- 0.04 3 10

PF17668 (3/3) Acetyltransferase (GNAT) domain
PF13530 (3/3) Sterol carrier protein domain
PF13527 (3/3) Acetyltransferase (GNAT) domain
PF07690 (3/3) Major Facilitator Superfamily
PF00553 (3/3) Cellulose binding domain
PF00457 (3/3) Glycosyl hydrolases family 11
PF05147 (2/3) Lanthionine synthetase C-like protein
PF02909 (2/3) Tetracyclin repressor-like, C-terminal domain
PF01636 (2/3) Phosphotransferase enzyme family
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_5129 75.74 +- 2.18 3 0 0 0 0.20 +- 0.16 3 20

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00377 (3/3) anti-anti-sigma factor
TIGR00229 (3/3) PAS domain S-box protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13466 (3/3) STAS domain
PF12697 (3/3) Alpha/beta hydrolase family
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00664 (3/3) ABC transporter transmembrane region
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
PF18029 (2/3) Glyoxalase-like domain
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
jaccard_groups_1779 27.31 +- 11.08 3 0 0 0 0.17 +- 0.15 3 10

TIGR01692 (3/3) 3-hydroxyisobutyrate dehydrogenase
PF16113 (3/3) Enoyl-CoA hydratase/isomerase
PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01722 (2/3) methylmalonate-semialdehyde dehydrogenase (acylating)
PF00378 (2/3) Enoyl-CoA hydratase/isomerase
PF00171 (2/3) Aldehyde dehydrogenase family
jaccard_groups_1808 32.98 +- 18.88 7 0 0 0 0.12 +- 0.07 7 5

TIGR02089 (7/7) tartrate dehydrogenase
PF03466 (7/7) LysR substrate binding domain
PF00180 (7/7) Isocitrate/isopropylmalate dehydrogenase
PF00126 (7/7) Bacterial regulatory helix-turn-helix protein, lysR family
PF00202 (5/7) Aminotransferase class-III
jaccard_groups_1804 27.00 +- 4.57 2 0 1 0 0.15 +- 0.30 2 11

TIGR01034 (1/2) methionine adenosyltransferase
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02773 (1/2) S-adenosylmethionine synthetase, C-terminal domain
PF02772 (1/2) S-adenosylmethionine synthetase, central domain
PF01872 (1/2) RibD C-terminal domain
PF01596 (1/2) O-methyltransferase
PF01474 (1/2) Class-II DAHP synthetase family
PF01361 (1/2) Tautomerase enzyme
PF00438 (1/2) S-adenosylmethionine synthetase, N-terminal domain
PF00294 (1/2) pfkB family carbohydrate kinase
jaccard_groups_1802 187.51 +- 122.09 2 0 2 0 0.11 +- 0.28 2 12

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF02153 (1/2) Prephenate dehydrogenase
PF01061 (1/2) ABC-2 type transporter
PF00067 (1/2) Cytochrome P450
jaccard_groups_1775 26.88 +- 21.45 15 0 13 0 0.19 +- 0.28 15 5

PF09056 (15/15) Prokaryotic phospholipase A2
PF03403 (15/15) Platelet-activating factor acetylhydrolase, isoform II
PF02153 (15/15) Prephenate dehydrogenase
PF00005 (15/15) ABC transporter
PF03621 (14/15) MbtH-like protein
jaccard_groups_1800 141.18 +- 97.85 2 0 0 0 0.08 +- 0.10 2 11

PF14509 (2/2) Glycosyl-hydrolase 97 C-terminal, oligomerisation
PF14508 (2/2) Glycosyl-hydrolase 97 N-terminal
PF10566 (2/2) Glycoside hydrolase 97
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF10633 (1/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF08305 (1/2) NPCBM/NEW2 domain
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (1/2) Glycosyl hydrolases family 43
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01494 (1/2) FAD binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_1777 179.46 +- 296.14 26 0 6 0 0.10 +- 0.14 26 6

TIGR00797 (26/26) MATE efflux family protein
PF02784 (26/26) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02423 (26/26) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (26/26) MatE
PF00291 (26/26) Pyridoxal-phosphate dependent enzyme
PF02668 (20/26) Taurine catabolism dioxygenase TauD, TfdA family
jaccard_groups_1579 149.00 +- 109.00 2 0 0 0 0.02 +- 0.03 2 3

PF00491 (2/2) Arginase family
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02627 (1/2) Carboxymuconolactone decarboxylase family
jaccard_groups_1574 322.03 +- 278.06 5 0 4 0 0.08 +- 0.08 5 3

PF07883 (5/5) Cupin domain
PF07690 (3/5) Major Facilitator Superfamily
PF01613 (3/5) Flavin reductase like domain
jaccard_groups_1570 16.49 +- 1.14 10 0 0 0 0.18 +- 0.22 10 4

PF13722 (10/10) 5TM C-terminal transporter carbon starvation CstA
PF04328 (10/10) Selenoprotein, putative
PF02554 (10/10) Carbon starvation protein CstA
PF00583 (10/10) Acetyltransferase (GNAT) family
jaccard_groups_4093 706.99 +- 672.86 4 0 0 0 0.06 +- 0.16 4 18

TIGR03561 (4/4) peroxiredoxin, Ohr subfamily
PF13649 (4/4) Methyltransferase domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF09339 (4/4) IclR helix-turn-helix domain
PF09084 (4/4) NMT1/THI5 like
PF02566 (4/4) OsmC-like protein
PF01614 (4/4) Bacterial transcriptional regulator
PF01546 (4/4) Peptidase family M20/M25/M40
PF00561 (4/4) alpha/beta hydrolase fold
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00005 (4/4) ABC transporter
PF07992 (3/4) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (3/4) Putative cyclase
PF03972 (3/4) MmgE/PrpD family
PF02515 (3/4) CoA-transferase family III
PF01979 (3/4) Amidohydrolase family
PF00724 (3/4) NADH:flavin oxidoreductase / NADH oxidase family
PF03328 (2/4) HpcH/HpaI aldolase/citrate lyase family
jaccard_groups_4722 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_4727 388.50 +- 1.50 2 0 1 2 0.01 +- 0.00 2 4

PF04055 (2/2) Radical SAM superfamily
PF00106 (2/2) short chain dehydrogenase
PF09594 (1/2) Glycosyltransferase family 87
PF05147 (1/2) Lanthionine synthetase C-like protein
jaccard_groups_4435 202.96 +- 221.81 3 0 0 0 0.11 +- 0.24 3 5

PF04961 (3/3) Formiminotransferase-cyclodeaminase
PF02882 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01885 (3/3) RNA 2'-phosphotransferase, Tpt1 / KptA family
PF00763 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00561 (2/3) alpha/beta hydrolase fold
jaccard_groups_4436 675.26 +- 414.40 4 0 4 0 0.03 +- 0.12 4 20

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01198 (4/4) 6-phosphogluconolactonase
PF17668 (4/4) Acetyltransferase (GNAT) domain
PF13530 (4/4) Sterol carrier protein domain
PF13527 (4/4) Acetyltransferase (GNAT) domain
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08544 (4/4) GHMP kinases C terminal
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF02709 (4/4) N-terminal domain of galactosyltransferase
PF01761 (4/4) 3-dehydroquinate synthase
PF01182 (4/4) Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00834 (4/4) Ribulose-phosphate 3 epimerase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00293 (4/4) NUDIX domain
PF00288 (4/4) GHMP kinases N terminal domain
PF07676 (3/4) WD40-like Beta Propeller Repeat
PF01979 (3/4) Amidohydrolase family
jaccard_groups_1976 80.33 +- 29.25 3 0 0 0 0.08 +- 0.10 3 14

TIGR01891 (3/3) amidohydrolase
PF13738 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF06267 (3/3) Family of unknown function (DUF1028)
PF03466 (3/3) LysR substrate binding domain
PF01546 (3/3) Peptidase family M20/M25/M40
PF01042 (3/3) Endoribonuclease L-PSP
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (3/3) Sugar (and other) transporter
PF13302 (2/3) Acetyltransferase (GNAT) domain
PF13091 (2/3) PLD-like domain
PF11716 (2/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02386 (2/3) Cation transport protein
PF02254 (2/3) TrkA-N domain
PF02080 (2/3) TrkA-C domain
jaccard_groups_1119 290.50 +- 225.50 2 0 1 0 0.02 +- 0.02 2 2

PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/2) CoA-transferase family III
jaccard_groups_1975 245.72 +- 218.32 16 0 11 14 0.06 +- 0.10 16 6

PF13191 (16/16) AAA ATPase domain
PF00211 (16/16) Adenylate and Guanylate cyclase catalytic domain
PF00082 (16/16) Subtilase family
PF13185 (15/16) GAF domain
PF04055 (14/16) Radical SAM superfamily
PF14518 (11/16) Iron-containing redox enzyme
jaccard_groups_1114 224.23 +- 192.43 34 0 0 0 0.07 +- 0.07 34 6

PF16353 (34/34) Domain of unknown function(DUF4981)
PF02837 (34/34) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (34/34) Glycosyl hydrolases family 2, TIM barrel domain
PF02929 (33/34) Beta galactosidase small chain
PF00528 (28/34) Binding-protein-dependent transport system inner membrane component
PF00703 (23/34) Glycosyl hydrolases family 2
jaccard_groups_1110 49.21 +- 52.72 20 0 8 1 0.18 +- 0.17 20 21

TIGR00073 (20/20) hydrogenase accessory protein HypB
PF07503 (20/20) HypF finger
PF02492 (20/20) CobW/HypB/UreG, nucleotide-binding domain
PF01300 (20/20) Telomere recombination
TIGR00143 (19/20) carbamoyltransferase HypF
PF17788 (19/20) HypF Kae1-like domain
PF00708 (19/20) Acylphosphatase
TIGR00072 (18/20) hydrogenase maturation protease
PF01750 (18/20) Hydrogenase maturation protease
PF01155 (18/20) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF14720 (17/20) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF01058 (17/20) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (17/20) Nickel-dependent hydrogenase
TIGR02124 (16/20) hydrogenase expression/formation protein HypE
TIGR00075 (16/20) hydrogenase expression/formation protein HypD
TIGR00074 (16/20) hydrogenase assembly chaperone HypC/HupF
PF02769 (16/20) AIR synthase related protein, C-terminal domain
PF01924 (16/20) Hydrogenase formation hypA family
PF01455 (16/20) HupF/HypC family
PF00586 (16/20) AIR synthase related protein, N-terminal domain
PF14016 (12/20) Protein of unknown function (DUF4232)
jaccard_groups_1112 75.81 +- 51.96 9 0 1 0 0.05 +- 0.06 9 2

PF01557 (9/9) Fumarylacetoacetate (FAA) hydrolase family
PF00753 (6/9) Metallo-beta-lactamase superfamily
jaccard_groups_69 121.39 +- 166.05 28 0 6 0 0.06 +- 0.10 28 1

PF00248 (28/28) Aldo/keto reductase family
jaccard_groups_68 54.29 +- 40.76 2 0 0 0 0.10 +- 0.19 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF13649 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF00069 (1/2) Protein kinase domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_4549 41.84 +- 36.08 3 0 0 0 0.09 +- 0.07 3 3

PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF02195 (2/3) ParB-like nuclease domain
jaccard_groups_61 92.68 +- 113.99 27 0 4 0 0.08 +- 0.12 27 1

PF13302 (27/27) Acetyltransferase (GNAT) domain
jaccard_groups_60 217.21 +- 299.68 60 1 5 1 0.05 +- 0.11 59 1

PF00082 (60/60) Subtilase family
jaccard_groups_63 34.32 +- 35.88 22 0 3 0 0.20 +- 0.19 22 9

PF10935 (21/22) Protein of unknown function (DUF2637)
PF01580 (21/22) FtsK/SpoIIIE family
PF00589 (21/22) Phage integrase family
PF12728 (20/22) Helix-turn-helix domain
PF05122 (19/22) Mobile element transfer protein
PF14659 (15/22) Phage integrase, N-terminal SAM-like domain
TIGR01764 (12/22) DNA binding domain, excisionase family
PF07702 (12/22) UTRA domain
PF00392 (12/22) Bacterial regulatory proteins, gntR family
jaccard_groups_64 172.03 +- 156.39 2 0 2 0 0.07 +- 0.14 2 8

PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (1/2) DDE superfamily endonuclease
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF01979 (1/2) Amidohydrolase family
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00459 (1/2) Inositol monophosphatase family
PF00293 (1/2) NUDIX domain
jaccard_groups_1600 282.86 +- 357.60 24 0 0 0 0.05 +- 0.11 24 4

PF01636 (24/24) Phosphotransferase enzyme family
PF13520 (23/24) Amino acid permease
PF00120 (23/24) Glutamine synthetase, catalytic domain
PF00005 (22/24) ABC transporter
jaccard_groups_1602 55.71 +- 0.00 2 0 0 0 0.05 +- 0.06 2 4

TIGR01950 (2/2) redox-sensitive transcriptional activator SoxR
PF13411 (2/2) MerR HTH family regulatory protein
PF00877 (2/2) NlpC/P60 family
PF00069 (2/2) Protein kinase domain
jaccard_groups_1609 125.20 +- 94.97 16 0 1 0 0.08 +- 0.09 16 11

TIGR03217 (16/16) 4-hydroxy-2-oxovalerate aldolase
PF09290 (16/16) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (16/16) DmpG-like communication domain
PF01118 (16/16) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (16/16) HMGL-like
TIGR03215 (15/16) acetaldehyde dehydrogenase (acetylating)
PF07690 (12/16) Major Facilitator Superfamily
PF13621 (10/16) Cupin-like domain
PF03328 (10/16) HpcH/HpaI aldolase/citrate lyase family
PF02423 (10/16) Ornithine cyclodeaminase/mu-crystallin family
PF00155 (10/16) Aminotransferase class I and II
jaccard_groups_2371 25.06 +- 0.10 2 0 0 0 0.20 +- 0.36 2 9

TIGR00485 (2/2) translation elongation factor Tu
PF13828 (2/2) Domain of unknown function (DUF4190)
PF09913 (2/2) Predicted membrane protein (DUF2142)
PF08044 (2/2) Domain of unknown function (DUF1707)
PF04138 (2/2) GtrA-like protein
PF03144 (2/2) Elongation factor Tu domain 2
PF03143 (2/2) Elongation factor Tu C-terminal domain
PF00535 (2/2) Glycosyl transferase family 2
PF00009 (2/2) Elongation factor Tu GTP binding domain
jaccard_groups_4941 849.76 +- 141.18 3 0 3 0 0.01 +- 0.00 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF12850 (3/3) Calcineurin-like phosphoesterase superfamily domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01894 (3/3) Uncharacterised protein family UPF0047
PF00682 (3/3) HMGL-like
PF00462 (3/3) Glutaredoxin
PF00266 (3/3) Aminotransferase class-V
PF02222 (2/3) ATP-grasp domain
jaccard_groups_4942 135.86 +- 49.86 2 0 0 0 0.03 +- 0.04 2 4

PF05653 (2/2) Magnesium transporter NIPA
PF03576 (2/2) Peptidase family S58
PF01494 (2/2) FAD binding domain
PF00293 (2/2) NUDIX domain
jaccard_groups_4944 56.23 +- 12.56 3 0 3 0 0.16 +- 0.31 3 13

TIGR02814 (3/3) PfaD family protein
TIGR01733 (3/3) amino acid adenylation domain
TIGR00223 (3/3) aspartate 1-decarboxylase
TIGR00128 (3/3) malonyl CoA-acyl carrier protein transacylase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08241 (3/3) Methyltransferase domain
PF02261 (3/3) Aspartate decarboxylase
PF00891 (3/3) O-methyltransferase domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
jaccard_groups_4947 143.44 +- 47.43 3 0 3 0 0.09 +- 0.22 3 14

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF13460 (3/3) NAD(P)H-binding
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04264 (3/3) YceI-like domain
PF04072 (3/3) Leucine carboxyl methyltransferase
PF03321 (3/3) GH3 auxin-responsive promoter
PF14016 (2/3) Protein of unknown function (DUF4232)
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF02796 (2/3) Helix-turn-helix domain of resolvase
PF01695 (2/3) IstB-like ATP binding protein
PF00665 (2/3) Integrase core domain
jaccard_groups_4949 61.94 +- 1.47 2 0 0 2 0.06 +- 0.10 2 4

PF13649 (2/2) Methyltransferase domain
PF01183 (2/2) Glycosyl hydrolases family 25
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00881 (2/2) Nitroreductase family
jaccard_groups_5091 453.00 +- 240.54 3 0 2 0 0.01 +- 0.00 3 3

PF03928 (3/3) Haem-degrading
PF00106 (3/3) short chain dehydrogenase
PF03795 (2/3) YCII-related domain
jaccard_groups_4892 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
jaccard_groups_4890 1213.33 +- 324.28 3 0 3 3 0.01 +- 0.00 3 15

TIGR00566 (3/3) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF16861 (3/3) Carbamoyltransferase C-terminus
PF04055 (3/3) Radical SAM superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF18105 (2/3) PGM1 C-terminal domain
PF13535 (2/3) ATP-grasp domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF07690 (2/3) Major Facilitator Superfamily
PF06969 (2/3) HemN C-terminal domain
PF05977 (2/3) Transmembrane secretion effector
PF00501 (2/3) AMP-binding enzyme
jaccard_groups_4897 94.74 +- 50.75 3 0 0 0 0.05 +- 0.05 3 10

TIGR03668 (3/3) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (3/3) probable F420-dependent oxidoreductase, Rv2161c family
PF13377 (3/3) Periplasmic binding protein-like domain
PF03779 (3/3) SPW repeat
PF03729 (3/3) Short repeat of unknown function (DUF308)
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00296 (3/3) Luciferase-like monooxygenase
PF02322 (2/3) Cytochrome bd terminal oxidase subunit II
PF01654 (2/3) Cytochrome bd terminal oxidase subunit I
jaccard_groups_4895 151.88 +- 91.88 2 0 0 0 0.04 +- 0.05 2 11

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF13333 (1/2) Integrase core domain
PF13276 (1/2) HTH-like domain
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain
jaccard_groups_3336 107.50 +- 21.50 2 0 0 0 0.02 +- 0.01 2 3

TIGR03844 (2/2) cysteate synthase
PF00296 (2/2) Luciferase-like monooxygenase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_3990 47.54 +- 9.65 4 0 0 0 0.11 +- 0.23 4 7

PF10009 (4/4) Uncharacterized protein conserved in bacteria (DUF2252)
PF07731 (4/4) Multicopper oxidase
PF01063 (4/4) Amino-transferase class IV
PF00583 (4/4) Acetyltransferase (GNAT) family
PF07732 (3/4) Multicopper oxidase
PF02687 (3/4) FtsX-like permease family
PF00005 (3/4) ABC transporter
jaccard_groups_3991 66.05 +- 37.53 5 0 0 0 0.08 +- 0.20 5 5

PF09678 (5/5) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF01814 (5/5) Hemerythrin HHE cation binding domain
PF10002 (4/5) Predicted membrane protein (DUF2243)
PF09844 (4/5) Uncharacterized conserved protein (COG2071)
PF07228 (4/5) Stage II sporulation protein E (SpoIIE)
jaccard_groups_3994 290.61 +- 82.38 5 0 3 0 0.01 +- 0.00 5 5

PF13535 (5/5) ATP-grasp domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF05960 (5/5) Bacterial protein of unknown function (DUF885)
PF02195 (5/5) ParB-like nuclease domain
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_549 52.43 +- 64.42 35 0 14 0 0.11 +- 0.13 35 2

PF13378 (35/35) Enolase C-terminal domain-like
PF02746 (31/35) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
jaccard_groups_547 24.19 +- 9.45 9 0 0 8 0.16 +- 0.18 9 5

TIGR04186 (9/9) putative ATP-grasp target RiPP
PF14404 (9/9) Ribosomally synthesized peptide in Streptomyces species
TIGR04187 (8/9) ATP-grasp ribosomal peptide maturase, SAV_5884 family
PF08242 (6/9) Methyltransferase domain
PF00903 (6/9) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_546 210.27 +- 142.92 25 0 10 0 0.03 +- 0.06 25 2

PF00201 (24/25) UDP-glucoronosyl and UDP-glucosyl transferase
TIGR01426 (15/25) glycosyltransferase, MGT family
jaccard_groups_541 33.63 +- 11.52 6 0 0 0 0.14 +- 0.21 6 5

PF13302 (6/6) Acetyltransferase (GNAT) domain
PF12172 (6/6) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08445 (6/6) FR47-like protein
PF01796 (6/6) DUF35 OB-fold domain, acyl-CoA-associated
PF07681 (4/6) DoxX
jaccard_groups_4906 626.08 +- 123.15 3 0 1 0 0.02 +- 0.01 3 10

TIGR00107 (3/3) purine nucleoside phosphorylase
PF13377 (3/3) Periplasmic binding protein-like domain
PF07090 (3/3) Putative glutamine amidotransferase
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF02608 (3/3) ABC transporter substrate-binding protein PnrA-like
PF01979 (3/3) Amidohydrolase family
PF01048 (3/3) Phosphorylase superfamily
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00005 (3/3) ABC transporter
PF13449 (2/3) Esterase-like activity of phytase
jaccard_groups_542 208.20 +- 153.17 3 0 1 0 0.08 +- 0.15 3 9

PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00690 (3/3) Cation transporter/ATPase, N-terminus
PF00689 (3/3) Cation transporting ATPase, C-terminus
PF00122 (3/3) E1-E2 ATPase
TIGR01494 (2/3) HAD ATPase, P-type, family IC
PF12724 (2/3) Flavodoxin domain
PF12679 (2/3) ABC-2 family transporter protein
PF08962 (2/3) Domain of unknown function (DUF1876)
PF00005 (2/3) ABC transporter
jaccard_groups_400 15.87 +- 7.59 2 0 0 0 0.20 +- 0.18 2 4

PF01145 (2/2) SPFH domain / Band 7 family
PF15975 (1/2) Flotillin
PF12697 (1/2) Alpha/beta hydrolase family
PF02254 (1/2) TrkA-N domain
jaccard_groups_401 265.36 +- 254.29 13 0 8 0 0.02 +- 0.06 13 3

PF08545 (13/13) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (13/13) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (10/13) Phosphopantetheine attachment site
jaccard_groups_402 169.93 +- 322.47 113 0 4 0 0.15 +- 0.14 113 7

PF02449 (113/113) Beta-galactosidase
PF08532 (112/113) Beta-galactosidase trimerisation domain
PF00528 (107/113) Binding-protein-dependent transport system inner membrane component
PF08533 (103/113) Beta-galactosidase C-terminal domain
PF13416 (86/113) Bacterial extracellular solute-binding protein
PF01670 (83/113) Glycosyl hydrolase family 12
PF14498 (74/113) Glycosyl hydrolase family 65, N-terminal domain
jaccard_groups_2878 810.82 +- 562.49 4 0 0 0 0.05 +- 0.18 4 7

TIGR01726 (4/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF07729 (4/4) FCD domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00497 (4/4) Bacterial extracellular solute-binding proteins, family 3
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00005 (4/4) ABC transporter
PF00106 (2/4) short chain dehydrogenase
jaccard_groups_406 238.87 +- 306.19 10 0 2 0 0.08 +- 0.15 10 11

PF01979 (10/10) Amidohydrolase family
PF00699 (10/10) Urease beta subunit
PF00547 (10/10) Urease, gamma subunit
PF00449 (10/10) Urease alpha-subunit, N-terminal domain
TIGR01792 (9/10) urease, alpha subunit
TIGR00193 (9/10) urease, gamma subunit
TIGR00101 (9/10) urease accessory protein UreG
PF02492 (9/10) CobW/HypB/UreG, nucleotide-binding domain
PF01774 (9/10) UreD urease accessory protein
PF01730 (9/10) UreF
TIGR00192 (6/10) urease, beta subunit
jaccard_groups_6018 27.85 +- 4.40 2 0 0 0 0.11 +- 0.13 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF08751 (2/2) TrwC relaxase
PF03466 (2/2) LysR substrate binding domain
PF00872 (2/2) Transposase, Mutator family
PF00293 (2/2) NUDIX domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_6019 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_2069 56.62 +- 24.03 19 0 2 0 0.15 +- 0.20 19 9

PF16896 (19/19) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (19/19) Major Facilitator Superfamily
PF03807 (19/19) NADP oxidoreductase coenzyme F420-dependent
PF02733 (19/19) Dak1 domain
PF01261 (19/19) Xylose isomerase-like TIM barrel
PF00121 (19/19) Triosephosphate isomerase
TIGR02133 (18/19) ribose 5-phosphate isomerase
PF02734 (18/19) DAK2 domain
PF02502 (18/19) Ribose/Galactose Isomerase
jaccard_groups_2068 143.88 +- 148.88 6 0 0 0 0.07 +- 0.07 6 19

TIGR02712 (6/6) urea carboxylase
PF02786 (6/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (6/6) Biotin carboxylase C-terminal domain
PF02682 (6/6) Carboxyltransferase domain, subdomain C and D
PF02626 (6/6) Carboxyltransferase domain, subdomain A and B
PF01425 (6/6) Amidase
PF00364 (6/6) Biotin-requiring enzyme
PF00289 (6/6) Biotin carboxylase, N-terminal domain
TIGR03424 (5/6) urea carboxylase-associated protein 1
PF09347 (5/6) Domain of unknown function (DUF1989)
TIGR03425 (4/6) urea carboxylase-associated protein 2
PF00440 (4/6) Bacterial regulatory proteins, tetR family
TIGR02713 (3/6) allophanate hydrolase
TIGR01930 (3/6) acetyl-CoA C-acyltransferase
TIGR01509 (3/6) HAD hydrolase, family IA, variant 3
PF13520 (3/6) Amino acid permease
PF13419 (3/6) Haloacid dehalogenase-like hydrolase
PF02803 (3/6) Thiolase, C-terminal domain
PF00108 (3/6) Thiolase, N-terminal domain
jaccard_groups_3047 62.94 +- 7.17 3 0 0 0 0.16 +- 0.12 3 7

PF13601 (3/3) Winged helix DNA-binding domain
PF12698 (3/3) ABC-2 family transporter protein
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00135 (3/3) Carboxylesterase family
PF00005 (3/3) ABC transporter
PF01497 (2/3) Periplasmic binding protein
PF01032 (2/3) FecCD transport family
jaccard_groups_6542 134.85 +- 87.97 2 0 0 0 0.10 +- 0.23 2 17

TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (2/2) dihydroorotate dehydrogenase family protein
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF10415 (2/2) Fumarase C C-terminus
PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00206 (2/2) Lyase
PF13305 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13160 (1/2) Protein of unknown function (DUF3995)
PF07931 (1/2) Chloramphenicol phosphotransferase-like protein
PF02656 (1/2) Domain of unknown function (DUF202)
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_2064 265.42 +- 217.80 20 0 19 0 0.05 +- 0.10 20 10

TIGR01821 (20/20) 5-aminolevulinic acid synthase
PF16884 (20/20) N-terminal domain of oxidoreductase
PF08545 (20/20) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (20/20) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (20/20) Major Facilitator Superfamily
PF02668 (20/20) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (20/20) Aminotransferase class I and II
PF00107 (20/20) Zinc-binding dehydrogenase
TIGR01891 (10/20) amidohydrolase
PF01546 (10/20) Peptidase family M20/M25/M40
jaccard_groups_2067 125.36 +- 94.28 4 0 0 0 0.07 +- 0.09 4 5

PF14742 (4/4) N-terminal domain of (some) glycogen debranching enzymes
PF06202 (3/4) Amylo-alpha-1,6-glucosidase
PF01261 (3/4) Xylose isomerase-like TIM barrel
PF00107 (3/4) Zinc-binding dehydrogenase
PF01204 (2/4) Trehalase
jaccard_groups_2061 16.84 +- 1.56 3 0 3 0 0.17 +- 0.21 3 9

PF13424 (3/3) Tetratricopeptide repeat
PF09997 (3/3) Predicted membrane protein (DUF2238)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF00348 (3/3) Polyprenyl synthetase
PF00144 (3/3) Beta-lactamase
PF00069 (3/3) Protein kinase domain
PF02342 (2/3) TerD domain
PF01987 (2/3) Mitochondrial biogenesis AIM24
PF00188 (2/3) Cysteine-rich secretory protein family
jaccard_groups_6544 85.65 +- 22.12 2 0 2 0 0.15 +- 0.11 2 13

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF08281 (2/2) Sigma-70, region 4
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF04542 (2/2) Sigma-70 region 2
PF04188 (2/2) Mannosyltransferase (PIG-V)
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00455 (2/2) DeoR C terminal sensor domain
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
jaccard_groups_6545 1290.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF13242 (2/2) HAD-hyrolase-like
PF06182 (2/2) ABC-2 family transporter protein
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00005 (2/2) ABC transporter
jaccard_groups_3422 77.23 +- 47.17 5 0 0 1 0.10 +- 0.20 5 10

PF09861 (5/5) Lactate racemase N-terminal domain
PF07729 (5/5) FCD domain
PF01969 (5/5) Protein of unknown function DUF111
PF00731 (5/5) AIR carboxylase
PF00392 (5/5) Bacterial regulatory proteins, gntR family
TIGR00299 (4/5) TIGR00299 family protein
PF04909 (4/5) Amidohydrolase
PF00248 (4/5) Aldo/keto reductase family
TIGR00268 (3/5) TIGR00268 family protein
PF02540 (3/5) NAD synthase
jaccard_groups_3420 179.84 +- 74.62 5 0 0 0 0.05 +- 0.04 5 10

PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (5/5) Major Facilitator Superfamily
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF04324 (5/5) BFD-like [2Fe-2S] binding domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF00384 (5/5) Molybdopterin oxidoreductase
PF18267 (3/5) Rubredoxin NAD+ reductase C-terminal domain
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
PF00501 (3/5) AMP-binding enzyme
jaccard_groups_2111 164.67 +- 67.05 14 0 14 0 0.15 +- 0.24 14 19

TIGR01181 (14/14) dTDP-glucose 4,6-dehydratase
PF16363 (14/14) GDP-mannose 4,6 dehydratase
PF07690 (14/14) Major Facilitator Superfamily
PF03559 (14/14) NDP-hexose 2,3-dehydratase
PF13561 (13/14) Enoyl-(Acyl carrier protein) reductase
PF10604 (13/14) Polyketide cyclase / dehydrase and lipid transport
PF02801 (13/14) Beta-ketoacyl synthase, C-terminal domain
PF01494 (13/14) FAD binding domain
PF01408 (13/14) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (13/14) NAD dependent epimerase/dehydratase family
PF00550 (13/14) Phosphopantetheine attachment site
PF00109 (13/14) Beta-ketoacyl synthase, N-terminal domain
PF00106 (13/14) short chain dehydrogenase
PF04673 (12/14) Polyketide synthesis cyclase
PF03358 (12/14) NADPH-dependent FMN reductase
PF01041 (11/14) DegT/DnrJ/EryC1/StrS aminotransferase family
PF04672 (9/14) S-adenosyl methyltransferase
PF01757 (9/14) Acyltransferase family
PF00248 (9/14) Aldo/keto reductase family
jaccard_groups_6169 13.16 +- 3.61 2 0 0 0 0.16 +- 0.29 2 5

TIGR03707 (2/2) polyphosphate kinase 2
PF12724 (2/2) Flavodoxin domain
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF00128 (2/2) Alpha amylase, catalytic domain
jaccard_groups_2117 27.37 +- 0.00 2 0 0 0 0.07 +- 0.03 2 3

PF08544 (2/2) GHMP kinases C terminal
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00288 (2/2) GHMP kinases N terminal domain
jaccard_groups_6494 286.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF05729 (1/2) NACHT domain
jaccard_groups_3193 555.78 +- 261.13 8 0 7 8 0.02 +- 0.02 8 16

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00778 (8/8) alkylhydroperoxidase AhpD family core domain
PF13454 (8/8) FAD-NAD(P)-binding
PF02896 (8/8) PEP-utilising enzyme, TIM barrel domain
PF02627 (8/8) Carboxymuconolactone decarboxylase family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (8/8) Pyridoxamine 5'-phosphate oxidase
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00005 (8/8) ABC transporter
TIGR01733 (7/8) amino acid adenylation domain
PF13193 (7/8) AMP-binding enzyme C-terminal domain
PF00550 (7/8) Phosphopantetheine attachment site
PF00501 (7/8) AMP-binding enzyme
PF00391 (5/8) PEP-utilising enzyme, mobile domain
jaccard_groups_3190 107.00 +- 19.58 2 0 2 0 0.04 +- 0.10 2 16

TIGR01760 (2/2) phage tail tape measure protein, TP901 family, core region
PF16945 (2/2) Putative lactococcus lactis phage r1t holin
PF10145 (2/2) Phage-related minor tail protein
PF05709 (2/2) Phage tail protein
PF04883 (2/2) Bacteriophage HK97-gp10, putative tail-component
PF03837 (2/2) RecT family
PF02384 (2/2) N-6 DNA Methylase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00216 (2/2) Bacterial DNA-binding protein
PF00145 (2/2) C-5 cytosine-specific DNA methylase
TIGR01913 (1/2) phage recombination protein Bet
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF13830 (1/2) Domain of unknown function (DUF4192)
PF12705 (1/2) PD-(D/E)XK nuclease superfamily
PF00293 (1/2) NUDIX domain
PF00005 (1/2) ABC transporter
jaccard_groups_3197 84.52 +- 19.96 8 0 0 0 0.15 +- 0.27 8 14

TIGR03083 (8/8) uncharacterized Actinobacterial protein TIGR03083
PF13354 (8/8) Beta-lactamase enzyme family
PF09423 (8/8) PhoD-like phosphatase
PF09339 (8/8) IclR helix-turn-helix domain
PF08402 (8/8) TOBE domain
PF02894 (8/8) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (8/8) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01614 (8/8) Bacterial transcriptional regulator
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF13581 (7/8) Histidine kinase-like ATPase domain
PF01547 (6/8) Bacterial extracellular solute-binding protein
PF01370 (6/8) NAD dependent epimerase/dehydratase family
jaccard_groups_3195 83.59 +- 41.98 8 0 6 0 0.13 +- 0.25 8 9

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03567 (8/8) FMN reductase
TIGR01208 (8/8) glucose-1-phosphate thymidylyltransferase
TIGR01181 (8/8) dTDP-glucose 4,6-dehydratase
PF16363 (8/8) GDP-mannose 4,6 dehydratase
PF03358 (8/8) NADPH-dependent FMN reductase
PF01494 (8/8) FAD binding domain
PF00483 (8/8) Nucleotidyl transferase
PF00296 (8/8) Luciferase-like monooxygenase
jaccard_groups_2870 28.17 +- 12.02 4 0 4 0 0.20 +- 0.30 4 19

TIGR02350 (4/4) chaperone protein DnaK
PF02797 (4/4) Chalcone and stilbene synthases, C-terminal domain
PF01025 (4/4) GrpE
PF00195 (4/4) Chalcone and stilbene synthases, N-terminal domain
PF00067 (4/4) Cytochrome P450
PF00012 (4/4) Hsp70 protein
PF17765 (3/4) MmyB-like transcription regulator ligand binding domain
PF13560 (3/4) Helix-turn-helix domain
PF09129 (3/4) Cholesterol oxidase, substrate-binding
PF06386 (3/4) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (3/4) Gas vesicle synthesis protein GvpO
PF05121 (3/4) Gas vesicle protein K
PF05120 (3/4) Gas vesicle protein G
PF03364 (3/4) Polyketide cyclase / dehydrase and lipid transport
PF01565 (3/4) FAD binding domain
PF00741 (3/4) Gas vesicle protein
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF02371 (2/4) Transposase IS116/IS110/IS902 family
PF01548 (2/4) Transposase
jaccard_groups_3608 47.76 +- 26.02 2 0 0 0 0.08 +- 0.16 2 6

PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF07994 (1/2) Myo-inositol-1-phosphate synthase
PF02735 (1/2) Ku70/Ku80 beta-barrel domain
PF01658 (1/2) Myo-inositol-1-phosphate synthase
PF00801 (1/2) PKD domain
jaccard_groups_2692 189.93 +- 207.96 9 0 0 0 0.08 +- 0.16 9 6

PF01497 (9/9) Periplasmic binding protein
PF01032 (9/9) FecCD transport family
PF00005 (9/9) ABC transporter
PF12833 (8/9) Helix-turn-helix domain
PF02311 (7/9) AraC-like ligand binding domain
PF02518 (5/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
jaccard_groups_3607 522.65 +- 377.62 3 0 2 0 0.03 +- 0.02 3 8

PF13452 (3/3) N-terminal half of MaoC dehydratase
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (3/3) Flavin reductase like domain
PF01575 (3/3) MaoC like domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00890 (3/3) FAD binding domain
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_5466 10.48 +- 0.36 2 0 0 0 0.19 +- 0.09 2 5

TIGR02306 (2/2) RNA ligase
PF13602 (2/2) Zinc-binding dehydrogenase
PF09414 (2/2) RNA ligase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_2808 846.00 +- 451.06 5 0 1 0 0.04 +- 0.07 5 17

TIGR02118 (5/5) conserved hypothetical protein
PF17932 (5/5) Tetracyclin repressor-like, C-terminal domain
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07110 (5/5) EthD domain
PF02803 (5/5) Thiolase, C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF01796 (5/5) DUF35 OB-fold domain, acyl-CoA-associated
PF01636 (5/5) Phosphotransferase enzyme family
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00378 (5/5) Enoyl-CoA hydratase/isomerase
PF00108 (5/5) Thiolase, N-terminal domain
TIGR01930 (4/5) acetyl-CoA C-acyltransferase
jaccard_groups_2807 154.14 +- 79.86 2 0 0 0 0.02 +- 0.03 2 9

PF13602 (2/2) Zinc-binding dehydrogenase
PF13564 (2/2) DoxX-like family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
jaccard_groups_2804 355.03 +- 133.79 5 0 0 0 0.01 +- 0.00 5 9

PF17853 (5/5) GGDEF-like domain
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF12450 (5/5) von Willebrand factor
PF12034 (5/5) Domain of unknown function (DUF3520)
PF08592 (5/5) Domain of unknown function (DUF1772)
PF03704 (5/5) Bacterial transcriptional activator domain
PF00092 (5/5) von Willebrand factor type A domain
PF13185 (3/5) GAF domain
PF00486 (3/5) Transcriptional regulatory protein, C terminal
jaccard_groups_5864 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_5867 16.45 +- 2.12 2 0 0 0 0.12 +- 0.23 2 5

PF13228 (2/2) Domain of unknown function (DUF4037)
PF08713 (2/2) DNA alkylation repair enzyme
PF07528 (2/2) DZF domain
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF00583 (2/2) Acetyltransferase (GNAT) family
jaccard_groups_718 93.33 +- 59.99 4 0 0 0 0.03 +- 0.02 4 2

PF03403 (4/4) Platelet-activating factor acetylhydrolase, isoform II
PF08241 (3/4) Methyltransferase domain
jaccard_groups_719 161.10 +- 176.89 16 0 0 0 0.09 +- 0.21 16 6

PF07228 (15/16) Stage II sporulation protein E (SpoIIE)
PF07739 (14/16) TipAS antibiotic-recognition domain
PF13411 (13/16) MerR HTH family regulatory protein
PF07690 (13/16) Major Facilitator Superfamily
PF01551 (13/16) Peptidase family M23
PF00291 (11/16) Pyridoxal-phosphate dependent enzyme
jaccard_groups_8 361.39 +- 511.39 189 13 148 124 0.06 +- 0.13 176 4

PF00005 (189/189) ABC transporter
PF00069 (155/189) Protein kinase domain
PF00664 (147/189) ABC transporter transmembrane region
PF05147 (123/189) Lanthionine synthetase C-like protein
jaccard_groups_9 129.56 +- 173.66 69 0 18 51 0.10 +- 0.12 69 2

PF00069 (69/69) Protein kinase domain
PF13360 (38/69) PQQ-like domain
jaccard_groups_6 84.47 +- 72.58 30 0 7 0 0.08 +- 0.16 30 2

PF13560 (30/30) Helix-turn-helix domain
PF17765 (19/30) MmyB-like transcription regulator ligand binding domain
jaccard_groups_7 99.07 +- 107.27 10 0 2 0 0.13 +- 0.26 10 3

PF03777 (10/10) ChpA-C
PF02156 (6/10) Glycosyl hydrolase family 26
TIGR01167 (5/10) LPXTG cell wall anchor domain
jaccard_groups_4 173.38 +- 273.67 49 1 10 2 0.07 +- 0.14 48 1

PF07690 (49/49) Major Facilitator Superfamily
jaccard_groups_5 132.03 +- 198.67 63 0 11 0 0.09 +- 0.17 63 3

PF08281 (61/63) Sigma-70, region 4
PF04542 (61/63) Sigma-70 region 2
TIGR02937 (43/63) RNA polymerase sigma factor, sigma-70 family
jaccard_groups_2 201.00 +- 197.97 25 0 5 1 0.06 +- 0.10 25 1

PF00440 (25/25) Bacterial regulatory proteins, tetR family
jaccard_groups_3 136.83 +- 238.10 124 0 24 1 0.11 +- 0.22 124 3

PF07730 (122/124) Histidine kinase
PF00072 (121/124) Response regulator receiver domain
PF00196 (120/124) Bacterial regulatory proteins, luxR family
jaccard_groups_1 84.07 +- 113.83 86 0 9 1 0.12 +- 0.21 86 2

PF13560 (86/86) Helix-turn-helix domain
PF04149 (86/86) Domain of unknown function (DUF397)
jaccard_groups_2645 194.00 +- 64.00 2 0 0 0 0.01 +- 0.00 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07859 (2/2) alpha/beta hydrolase fold
PF00743 (2/2) Flavin-binding monooxygenase-like
jaccard_groups_2644 671.42 +- 474.76 11 0 0 0 0.04 +- 0.04 11 10

PF13407 (11/11) Periplasmic binding protein domain
PF03422 (11/11) Carbohydrate binding module (family 6)
PF02653 (11/11) Branched-chain amino acid transport system / permease component
PF01261 (11/11) Xylose isomerase-like TIM barrel
PF00801 (11/11) PKD domain
PF00005 (11/11) ABC transporter
PF11721 (7/11) Malectin domain
PF10054 (7/11) Predicted periplasmic lipoprotein (DUF2291)
PF07632 (7/11) Protein of unknown function (DUF1593)
PF04198 (7/11) Putative sugar-binding domain
jaccard_groups_2646 117.56 +- 43.17 4 0 4 0 0.10 +- 0.18 4 10

TIGR03885 (4/4) probable non-F420 flavinoid oxidoreductase
PF18306 (4/4) SLOG cluster4 family
PF16657 (4/4) Maltogenic Amylase, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03641 (4/4) Possible lysine decarboxylase
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (4/4) Polysaccharide deacetylase
PF00553 (4/4) Cellulose binding domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00128 (4/4) Alpha amylase, catalytic domain
jaccard_groups_5599 1186.17 +- 232.83 2 0 2 2 0.01 +- 0.00 2 13

PF13580 (2/2) SIS domain
PF08544 (2/2) GHMP kinases C terminal
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF01761 (2/2) 3-dehydroquinate synthase
PF01555 (2/2) DNA methylase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01087 (2/2) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00288 (2/2) GHMP kinases N terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_2643 136.54 +- 108.75 4 0 4 0 0.06 +- 0.05 4 7

PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00535 (4/4) Glycosyl transferase family 2
PF00501 (4/4) AMP-binding enzyme
PF00067 (4/4) Cytochrome P450
PF13563 (3/4) 2'-5' RNA ligase superfamily
jaccard_groups_24 171.54 +- 219.55 9 0 1 0 0.05 +- 0.06 9 2

PF13191 (7/9) AAA ATPase domain
PF00196 (6/9) Bacterial regulatory proteins, luxR family
jaccard_groups_5595 538.57 +- 241.43 2 0 2 0 0.01 +- 0.02 2 6

PF07969 (2/2) Amidohydrolase family
PF07859 (2/2) alpha/beta hydrolase fold
PF07729 (2/2) FCD domain
PF02126 (2/2) Phosphotriesterase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_5597 106.52 +- 6.52 2 0 0 0 0.04 +- 0.01 2 4

TIGR01733 (2/2) amino acid adenylation domain
PF07859 (2/2) alpha/beta hydrolase fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
jaccard_groups_5977 520.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF16916 (2/2) Dimerisation domain of Zinc Transporter
PF07729 (2/2) FCD domain
PF01545 (2/2) Cation efflux family
PF01266 (2/2) FAD dependent oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_2483 196.48 +- 78.78 13 0 0 13 0.02 +- 0.01 13 5

PF08282 (13/13) haloacid dehalogenase-like hydrolase
PF04339 (13/13) Peptidogalycan biosysnthesis/recognition
PF04055 (13/13) Radical SAM superfamily
PF00303 (13/13) Thymidylate synthase
PF13480 (7/13) Acetyltransferase (GNAT) domain
jaccard_groups_5605 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
jaccard_groups_5606 18.84 +- 0.27 2 0 1 0 0.21 +- 0.32 2 5

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF03060 (2/2) Nitronate monooxygenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02467 (2/2) Transcription factor WhiB
jaccard_groups_2487 61.56 +- 15.84 2 0 0 0 0.07 +- 0.08 2 13

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF14325 (2/2) Domain of unknown function (DUF4383)
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
TIGR01828 (1/2) pyruvate, phosphate dikinase
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (1/2) B12 binding domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00582 (1/2) Universal stress protein family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
jaccard_groups_5601 59.67 +- 13.45 2 0 1 0 0.06 +- 0.05 2 7

TIGR00638 (2/2) molybdenum-pterin binding domain
PF12802 (2/2) MarR family
PF03459 (2/2) TOBE domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF00480 (2/2) ROK family
PF06224 (1/2) Winged helix DNA-binding domain
PF00376 (1/2) MerR family regulatory protein
jaccard_groups_5918 208.79 +- 51.21 2 0 2 0 0.05 +- 0.09 2 9

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07920 (2/2) Protein of unknown function (DUF1684)
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02655 (2/2) ATP-grasp domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (2/2) ABC transporter
jaccard_groups_5268 68.84 +- 20.47 2 0 0 0 0.05 +- 0.06 2 4

TIGR03382 (2/2) Myxococcales GC_trans_RRR domain
PF13285 (2/2) Domain of unknown function (DUF4073)
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
PF00149 (2/2) Calcineurin-like phosphoesterase
jaccard_groups_2248 935.62 +- 929.52 16 0 1 1 0.06 +- 0.14 16 8

PF00528 (16/16) Binding-protein-dependent transport system inner membrane component
PF00005 (16/16) ABC transporter
PF00496 (15/16) Bacterial extracellular solute-binding proteins, family 5 Middle
TIGR03860 (13/16) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (13/16) Luciferase-like monooxygenase
PF08352 (10/16) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (10/16) Acyl-CoA dehydrogenase, C-terminal domain
PF00248 (9/16) Aldo/keto reductase family
jaccard_groups_5913 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
jaccard_groups_5262 177.30 +- 36.57 2 0 0 0 0.06 +- 0.05 2 9

PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07729 (1/2) FCD domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
jaccard_groups_5916 696.60 +- 77.40 2 0 2 2 0.01 +- 0.00 2 9

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR00702 (2/2) YcaO-type kinase domain
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF08007 (2/2) Cupin superfamily protein
PF07812 (2/2) TfuA-like protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00583 (2/2) Acetyltransferase (GNAT) family
jaccard_groups_5917 218.47 +- 168.53 2 0 0 2 0.03 +- 0.07 2 5

TIGR04053 (2/2) radical SAM protein, BA_1875 family
TIGR00562 (2/2) protoporphyrinogen oxidase
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01593 (2/2) Flavin containing amine oxidoreductase
jaccard_groups_5042 948.91 +- 941.09 3 0 3 3 0.04 +- 0.15 3 15

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF03588 (3/3) Leucyl/phenylalanyl-tRNA protein transferase
PF03070 (3/3) TENA/THI-4/PQQC family
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00891 (3/3) O-methyltransferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (3/3) Cytochrome P450
PF07690 (2/3) Major Facilitator Superfamily
jaccard_groups_5043 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
jaccard_groups_5737 144.57 +- 0.26 2 0 2 0 0.13 +- 0.25 2 21

PF13602 (2/2) Zinc-binding dehydrogenase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF13358 (1/2) DDE superfamily endonuclease
PF05977 (1/2) Transmembrane secretion effector
PF01039 (1/2) Carboxyl transferase domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_5049 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_978 219.18 +- 92.36 13 0 4 0 0.02 +- 0.03 13 2

PF02771 (13/13) Acyl-CoA dehydrogenase, N-terminal domain
PF08028 (11/13) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_1349 16.64 +- 0.17 2 0 1 1 0.18 +- 0.20 2 8

TIGR00842 (2/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02028 (2/2) BCCT, betaine/carnitine/choline family transporter
PF13411 (1/2) MerR HTH family regulatory protein
PF08534 (1/2) Redoxin
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03747 (1/2) ADP-ribosylglycohydrolase
PF00293 (1/2) NUDIX domain
PF00069 (1/2) Protein kinase domain
jaccard_groups_5139 214.86 +- 44.62 3 0 0 0 0.08 +- 0.07 3 16

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03564 (3/3) F420-dependent oxidoreductase, MSMEG_4879 family
PF18029 (3/3) Glyoxalase-like domain
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07920 (3/3) Protein of unknown function (DUF1684)
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR01726 (2/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF02574 (2/3) Homocysteine S-methyltransferase
PF00497 (2/3) Bacterial extracellular solute-binding proteins, family 3
jaccard_groups_1341 139.28 +- 286.34 32 0 3 0 0.13 +- 0.11 32 8

TIGR01234 (32/32) ribulokinase
PF02782 (32/32) FGGY family of carbohydrate kinases, C-terminal domain
PF11762 (31/32) L-arabinose isomerase C-terminal domain
PF02610 (31/32) L-arabinose isomerase
PF00596 (30/32) Class II Aldolase and Adducin N-terminal domain
PF00370 (27/32) FGGY family of carbohydrate kinases, N-terminal domain
PF13377 (23/32) Periplasmic binding protein-like domain
PF00356 (23/32) Bacterial regulatory proteins, lacI family
jaccard_groups_5133 75.16 +- 10.16 2 0 0 0 0.04 +- 0.02 2 7

PF18164 (2/2) GNAT-like C-terminal domain
PF18082 (2/2) Domain of unknown function (DUF5596)
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00912 (1/2) Transglycosylase
jaccard_groups_5131 647.33 +- 185.73 3 0 2 0 0.01 +- 0.00 3 4

PF10017 (3/3) Histidine-specific methyltransferase, SAM-dependent
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF02450 (3/3) Lecithin:cholesterol acyltransferase
PF00400 (3/3) WD domain, G-beta repeat
jaccard_groups_1346 20.17 +- 3.90 5 0 0 0 0.10 +- 0.13 5 2

PF03773 (5/5) Predicted permease
TIGR03943 (3/5) TIGR03943 family protein
jaccard_groups_1745 38.23 +- 32.58 4 0 0 0 0.08 +- 0.12 4 5

TIGR00546 (4/4) apolipoprotein N-acyltransferase
PF13577 (4/4) SnoaL-like domain
PF01794 (4/4) Ferric reductase like transmembrane component
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00582 (4/4) Universal stress protein family
jaccard_groups_1296 218.47 +- 192.71 20 0 20 0 0.06 +- 0.09 20 15

PF14765 (20/20) Polyketide synthase dehydratase
PF08659 (20/20) KR domain
PF02801 (20/20) Beta-ketoacyl synthase, C-terminal domain
PF00698 (20/20) Acyl transferase domain
PF00550 (20/20) Phosphopantetheine attachment site
PF00201 (20/20) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (20/20) Beta-ketoacyl synthase, N-terminal domain
PF16197 (19/20) Ketoacyl-synthetase C-terminal extension
PF03060 (18/20) Nitronate monooxygenase
PF01648 (18/20) 4'-phosphopantetheinyl transferase superfamily
TIGR01426 (15/20) glycosyltransferase, MGT family
PF00561 (14/20) alpha/beta hydrolase fold
PF00005 (11/20) ABC transporter
PF13489 (10/20) Methyltransferase domain
PF00664 (10/20) ABC transporter transmembrane region
jaccard_groups_1295 74.53 +- 29.23 3 0 1 0 0.03 +- 0.03 3 1

PF04231 (3/3) Endonuclease I
jaccard_groups_1746 507.65 +- 259.19 29 0 7 29 0.02 +- 0.04 29 10

PF14833 (29/29) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (29/29) Glutamine amidotransferase domain
PF13480 (29/29) Acetyltransferase (GNAT) domain
PF07690 (29/29) Major Facilitator Superfamily
PF03641 (29/29) Possible lysine decarboxylase
PF03446 (29/29) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (29/29) N-terminal domain of galactosyltransferase
PF01041 (29/29) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (29/29) Asparagine synthase
PF00300 (29/29) Histidine phosphatase superfamily (branch 1)
jaccard_groups_1741 283.46 +- 213.20 7 0 1 0 0.02 +- 0.01 7 16

TIGR02593 (7/7) CRISPR-associated protein Cas5
TIGR02585 (7/7) CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP
TIGR01596 (7/7) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (7/7) CRISPR-associated helicase Cas3
PF09704 (7/7) CRISPR-associated protein (Cas_Cas5)
PF01930 (7/7) Domain of unknown function DUF83
PF01881 (7/7) CRISPR associated protein Cas6
PF01867 (7/7) CRISPR associated protein Cas1
TIGR03641 (6/7) CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP
TIGR01573 (6/7) CRISPR-associated endonuclease Cas2
PF09827 (6/7) CRISPR associated protein Cas2
PF18019 (5/7) HD domain
PF00270 (5/7) DEAD/DEAH box helicase
TIGR03804 (4/7) parallel beta-helix repeat
TIGR01877 (4/7) CRISPR-associated endoribonuclease Cas6
PF13229 (4/7) Right handed beta helix region
jaccard_groups_1740 368.15 +- 334.78 22 0 1 0 0.04 +- 0.07 22 15

PF16355 (22/22) Domain of unknown function (DUF4982)
PF14310 (22/22) Fibronectin type III-like domain
PF02836 (22/22) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (22/22) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (22/22) Glycosyl hydrolase family 3 N terminal domain
PF00703 (22/22) Glycosyl hydrolases family 2
PF18565 (21/22) Glycoside hydrolase family 2 C-terminal domain 5
PF02837 (21/22) Glycosyl hydrolases family 2, sugar binding domain
PF17390 (19/22) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (19/22) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (19/22) Alpha-L-rhamnosidase N-terminal domain
PF07859 (19/22) alpha/beta hydrolase fold
PF05592 (19/22) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00135 (15/22) Carboxylesterase family
PF00106 (13/22) short chain dehydrogenase
jaccard_groups_158 99.46 +- 86.95 5 0 0 0 0.05 +- 0.06 5 4

TIGR00350 (5/5) cell envelope-related function transcriptional attenuator common domain
PF03816 (5/5) Cell envelope-related transcriptional attenuator domain
PF13641 (4/5) Glycosyltransferase like family 2
PF01522 (4/5) Polysaccharide deacetylase
jaccard_groups_159 351.69 +- 298.31 2 0 1 0 0.04 +- 0.05 2 4

TIGR03296 (2/2) M6 family metalloprotease domain
PF05547 (1/2) Immune inhibitor A peptidase M6
PF00296 (1/2) Luciferase-like monooxygenase
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_152 72.50 +- 87.33 16 0 1 0 0.09 +- 0.14 16 1

PF01243 (16/16) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_153 78.36 +- 165.55 140 0 3 0 0.18 +- 0.34 140 7

PF00482 (140/140) Type II secretion system (T2SS), protein F
PF14029 (139/140) Protein of unknown function (DUF4244)
PF00437 (124/140) Type II/IV secretion system protein
TIGR03819 (121/140) helicase/secretion neighborhood ATPase
TIGR03815 (117/140) helicase/secretion neighborhood CpaE-like protein
TIGR03816 (98/140) helicase/secretion neighborhood TadE-like protein
PF13400 (83/140) Putative Flp pilus-assembly TadE/G-like
jaccard_groups_150 105.17 +- 82.13 8 0 0 0 0.09 +- 0.16 8 1

PF04672 (8/8) S-adenosyl methyltransferase
jaccard_groups_151 92.70 +- 59.43 6 0 0 0 0.08 +- 0.17 6 3

PF07508 (6/6) Recombinase
PF00239 (6/6) Resolvase, N terminal domain
PF13408 (3/6) Recombinase zinc beta ribbon domain
jaccard_groups_157 176.27 +- 134.41 51 0 0 0 0.04 +- 0.06 51 2

PF06737 (51/51) Transglycosylase-like domain
PF01476 (51/51) LysM domain
jaccard_groups_155 97.35 +- 87.00 8 0 0 0 0.05 +- 0.06 8 1

PF09335 (8/8) SNARE associated Golgi protein
jaccard_groups_398 26.49 +- 10.70 2 0 0 0 0.12 +- 0.20 2 8

PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF11188 (2/2) Protein of unknown function (DUF2975)
PF01494 (2/2) FAD binding domain
PF13458 (1/2) Periplasmic binding protein
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF09017 (1/2) Microbial transglutaminase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01474 (1/2) Class-II DAHP synthetase family
jaccard_groups_399 151.28 +- 201.40 11 0 2 0 0.07 +- 0.09 11 1

PF00355 (11/11) Rieske [2Fe-2S] domain
jaccard_groups_797 28.94 +- 13.74 3 0 1 0 0.09 +- 0.15 3 6

PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF03475 (2/3) 3-alpha domain
PF03473 (2/3) MOSC domain
PF00970 (2/3) Oxidoreductase FAD-binding domain
PF00561 (2/3) alpha/beta hydrolase fold
jaccard_groups_5407 1092.61 +- 307.39 2 0 0 0 0.01 +- 0.01 2 15

TIGR00148 (2/2) decarboxylase, UbiD family
PF12697 (2/2) Alpha/beta hydrolase family
PF09084 (2/2) NMT1/THI5 like
PF07729 (2/2) FCD domain
PF04909 (2/2) Amidohydrolase
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
jaccard_groups_392 111.52 +- 105.81 23 0 3 1 0.08 +- 0.19 23 4

PF12161 (23/23) HsdM N-terminal domain
PF02384 (23/23) N-6 DNA Methylase
PF01420 (20/23) Type I restriction modification DNA specificity domain
PF04313 (19/23) Type I restriction enzyme R protein N terminus (HSDR_N)
jaccard_groups_393 101.31 +- 104.00 49 0 1 0 0.06 +- 0.08 49 3

PF12833 (49/49) Helix-turn-helix domain
PF02311 (49/49) AraC-like ligand binding domain
PF00150 (33/49) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_394 151.11 +- 94.05 7 0 0 7 0.04 +- 0.09 7 1

PF00733 (7/7) Asparagine synthase
jaccard_groups_4159 75.06 +- 30.73 3 0 3 0 0.14 +- 0.19 3 8

PF12833 (3/3) Helix-turn-helix domain
PF03259 (3/3) Roadblock/LC7 domain
PF01965 (3/3) DJ-1/PfpI family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (3/3) Aldehyde dehydrogenase family
PF04237 (2/3) YjbR
jaccard_groups_1904 90.57 +- 69.83 17 0 0 0 0.10 +- 0.10 17 5

PF01670 (17/17) Glycosyl hydrolase family 12
PF00553 (17/17) Cellulose binding domain
PF07729 (16/17) FCD domain
PF00392 (16/17) Bacterial regulatory proteins, gntR family
PF03067 (9/17) Lytic polysaccharide mono-oxygenase, cellulose-degrading
jaccard_groups_4153 712.50 +- 67.50 2 0 1 1 0.01 +- 0.00 2 6

PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
PF04055 (1/2) Radical SAM superfamily
jaccard_groups_1327 22.51 +- 20.25 18 0 0 0 0.20 +- 0.37 18 7

PF13517 (18/18) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF07859 (18/18) alpha/beta hydrolase fold
PF07730 (18/18) Histidine kinase
PF01839 (18/18) FG-GAP repeat
PF00196 (18/18) Bacterial regulatory proteins, luxR family
PF00072 (18/18) Response regulator receiver domain
PF13460 (15/18) NAD(P)H-binding
jaccard_groups_4405 13.58 +- 0.00 2 0 0 0 0.15 +- 0.15 2 3

PF03621 (2/2) MbtH-like protein
PF01435 (2/2) Peptidase family M48
PF01186 (2/2) Lysyl oxidase
jaccard_groups_4404 1421.75 +- 4.76 4 0 4 0 0.01 +- 0.00 4 7

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (4/4) Condensation domain
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
jaccard_groups_1909 46.49 +- 20.71 3 0 0 0 0.08 +- 0.08 3 5

PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09335 (3/3) SNARE associated Golgi protein
PF07532 (3/3) Bacterial Ig-like domain (group 4)
PF04616 (3/3) Glycosyl hydrolases family 43
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_1908 211.51 +- 213.36 5 0 0 3 0.06 +- 0.11 5 4

PF18604 (5/5) Pre ATP-grasp domain
PF18105 (5/5) PGM1 C-terminal domain
PF07690 (3/5) Major Facilitator Superfamily
PF04055 (3/5) Radical SAM superfamily
jaccard_groups_4399 366.71 +- 296.41 4 0 4 4 0.04 +- 0.08 4 10

TIGR03297 (4/4) phosphonopyruvate decarboxylase
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF12804 (4/4) MobA-like NTP transferase domain
PF04055 (4/4) Radical SAM superfamily
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02310 (4/4) B12 binding domain
TIGR03945 (3/4) 2,3-diaminopropionate biosynthesis protein SbnA
PF14907 (3/4) Uncharacterised nucleotidyltransferase
PF00291 (3/4) Pyridoxal-phosphate dependent enzyme
jaccard_groups_4398 385.53 +- 252.42 4 0 4 4 0.04 +- 0.16 4 7

PF16861 (4/4) Carbamoyltransferase C-terminus
PF12840 (4/4) Helix-turn-helix domain
PF04055 (4/4) Radical SAM superfamily
PF02543 (4/4) Carbamoyltransferase N-terminus
PF01546 (4/4) Peptidase family M20/M25/M40
PF00891 (4/4) O-methyltransferase domain
PF00155 (4/4) Aminotransferase class I and II
jaccard_groups_1125 53.84 +- 33.84 33 0 3 2 0.18 +- 0.22 33 12

TIGR01374 (33/33) sarcosine oxidase, delta subunit family
PF08669 (33/33) Glycine cleavage T-protein C-terminal barrel domain
PF04267 (33/33) Sarcosine oxidase, delta subunit family
PF01571 (33/33) Aminomethyltransferase folate-binding domain
TIGR01373 (32/33) sarcosine oxidase, beta subunit family
PF13510 (32/33) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (32/33) Pyridine nucleotide-disulphide oxidoreductase
PF01266 (32/33) FAD dependent oxidoreductase
PF17806 (31/33) Sarcosine oxidase A3 domain
PF04268 (31/33) Sarcosine oxidase, gamma subunit family
TIGR01372 (22/33) sarcosine oxidase, alpha subunit family
PF16350 (21/33) FAD dependent oxidoreductase central domain
jaccard_groups_1124 18.92 +- 2.23 2 0 0 0 0.16 +- 0.32 2 11

TIGR01550 (2/2) death-on-curing family protein
PF07690 (2/2) Major Facilitator Superfamily
PF02661 (2/2) Fic/DOC family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
PF14659 (1/2) Phage integrase, N-terminal SAM-like domain
PF09339 (1/2) IclR helix-turn-helix domain
PF05362 (1/2) Lon protease (S16) C-terminal proteolytic domain
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01402 (1/2) Ribbon-helix-helix protein, copG family
PF00656 (1/2) Caspase domain
PF00082 (1/2) Subtilase family
jaccard_groups_1126 51.61 +- 21.50 5 0 1 0 0.06 +- 0.05 5 4

TIGR00476 (5/5) selenide, water dikinase
PF02769 (5/5) AIR synthase related protein, C-terminal domain
PF01471 (5/5) Putative peptidoglycan binding domain
PF00586 (5/5) AIR synthase related protein, N-terminal domain
jaccard_groups_1128 133.43 +- 105.21 32 0 32 0 0.16 +- 0.28 32 12

PF02801 (31/32) Beta-ketoacyl synthase, C-terminal domain
PF00550 (31/32) Phosphopantetheine attachment site
PF00109 (31/32) Beta-ketoacyl synthase, N-terminal domain
PF10604 (30/32) Polyketide cyclase / dehydrase and lipid transport
PF00106 (30/32) short chain dehydrogenase
PF07690 (28/32) Major Facilitator Superfamily
PF04673 (28/32) Polyketide synthesis cyclase
PF01494 (24/32) FAD binding domain
PF13561 (22/32) Enoyl-(Acyl carrier protein) reductase
PF01039 (19/32) Carboxyl transferase domain
PF12697 (18/32) Alpha/beta hydrolase family
PF13822 (16/32) Acyl-CoA carboxylase epsilon subunit
jaccard_groups_4394 475.33 +- 60.36 3 0 0 3 0.01 +- 0.00 3 7

TIGR04267 (3/3) HEXXH motif domain
PF07690 (3/3) Major Facilitator Superfamily
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01523 (3/3) Putative modulator of DNA gyrase
PF00899 (3/3) ThiF family
TIGR03891 (2/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/3) Lantibiotic biosynthesis dehydratase C-term
jaccard_groups_4373 183.00 +- 118.00 2 0 0 0 0.03 +- 0.03 2 10

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF09339 (1/2) IclR helix-turn-helix domain
PF05899 (1/2) Protein of unknown function (DUF861)
PF01614 (1/2) Bacterial transcriptional regulator
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00248 (1/2) Aldo/keto reductase family
PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_3413 260.72 +- 115.49 7 0 0 0 0.01 +- 0.01 7 5

TIGR02532 (7/7) prepilin-type N-terminal cleavage/methylation domain
PF07963 (7/7) Prokaryotic N-terminal methylation motif
PF06750 (7/7) Bacterial Peptidase A24 N-terminal domain
PF03551 (7/7) Transcriptional regulator PadR-like family
PF01478 (7/7) Type IV leader peptidase family
jaccard_groups_78 213.98 +- 290.94 54 0 7 0 0.10 +- 0.12 54 2

PF00528 (52/54) Binding-protein-dependent transport system inner membrane component
PF13416 (51/54) Bacterial extracellular solute-binding protein
jaccard_groups_3005 93.70 +- 59.75 8 0 2 0 0.06 +- 0.07 8 6

PF03055 (8/8) Retinal pigment epithelial membrane protein
PF00067 (8/8) Cytochrome P450
TIGR04538 (7/8) cytochrome P450, cyclodipeptide synthase-associated
PF13191 (5/8) AAA ATPase domain
PF07690 (5/8) Major Facilitator Superfamily
PF10604 (4/8) Polyketide cyclase / dehydrase and lipid transport
jaccard_groups_73 210.37 +- 338.47 48 0 23 4 0.12 +- 0.21 48 3

PF00005 (48/48) ABC transporter
PF01061 (46/48) ABC-2 type transporter
PF00069 (25/48) Protein kinase domain
jaccard_groups_76 308.69 +- 288.61 9 0 1 0 0.06 +- 0.13 9 2

PF09339 (9/9) IclR helix-turn-helix domain
PF01614 (9/9) Bacterial transcriptional regulator
jaccard_groups_74 41.00 +- 11.00 2 0 2 0 0.18 +- 0.32 2 8

TIGR00377 (2/2) anti-anti-sigma factor
PF13466 (2/2) STAS domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF07702 (1/2) UTRA domain
PF04191 (1/2) Phospholipid methyltransferase
PF02541 (1/2) Ppx/GppA phosphatase family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00313 (1/2) 'Cold-shock' DNA-binding domain
jaccard_groups_75 121.79 +- 67.46 17 0 0 0 0.03 +- 0.04 17 4

PF00171 (17/17) Aldehyde dehydrogenase family
PF13370 (13/17) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (13/17) Pyridine nucleotide-disulphide oxidoreductase
PF00067 (13/17) Cytochrome P450
jaccard_groups_1630 72.09 +- 45.63 6 0 0 6 0.09 +- 0.10 6 12

TIGR03104 (6/6) asparagine synthase family amidotransferase
TIGR02050 (6/6) carboxylate-amine ligase, YbdK family
PF13537 (6/6) Glutamine amidotransferase domain
PF07676 (6/6) WD40-like Beta Propeller Repeat
PF04107 (6/6) Glutamate-cysteine ligase family 2(GCS2)
PF00733 (6/6) Asparagine synthase
PF00326 (5/6) Prolyl oligopeptidase family
TIGR01662 (3/6) HAD hydrolase, family IIIA
PF13242 (3/6) HAD-hyrolase-like
PF07690 (3/6) Major Facilitator Superfamily
PF01075 (3/6) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (3/6) Glycosyl transferase family 2
jaccard_groups_1632 38.31 +- 26.84 4 0 0 0 0.16 +- 0.29 4 10

TIGR00257 (4/4) uncharacterized protein, YigZ family
PF09186 (4/4) Domain of unknown function (DUF1949)
PF01205 (4/4) Uncharacterized protein family UPF0029
PF01497 (2/4) Periplasmic binding protein
PF01032 (2/4) FecCD transport family
PF00440 (2/4) Bacterial regulatory proteins, tetR family
PF00300 (2/4) Histidine phosphatase superfamily (branch 1)
PF00106 (2/4) short chain dehydrogenase
PF00067 (2/4) Cytochrome P450
PF00005 (2/4) ABC transporter
jaccard_groups_3415 482.46 +- 201.24 7 0 5 0 0.02 +- 0.05 7 7

PF13480 (7/7) Acetyltransferase (GNAT) domain
PF04389 (7/7) Peptidase family M28
PF01663 (7/7) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00155 (7/7) Aminotransferase class I and II
PF13649 (6/7) Methyltransferase domain
PF12850 (6/7) Calcineurin-like phosphoesterase superfamily domain
PF00334 (6/7) Nucleoside diphosphate kinase
jaccard_groups_3003 1302.60 +- 976.36 9 0 8 0 0.02 +- 0.07 9 10

PF13622 (9/9) Thioesterase-like superfamily
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00487 (9/9) Fatty acid desaturase
PF00301 (9/9) Rubredoxin
PF00067 (9/9) Cytochrome P450
PF07690 (8/9) Major Facilitator Superfamily
PF12679 (5/9) ABC-2 family transporter protein
PF12146 (5/9) Serine aminopeptidase, S33
PF00005 (5/9) ABC transporter
jaccard_groups_4975 685.54 +- 235.51 3 0 1 0 0.01 +- 0.01 3 14

TIGR00589 (3/3) methylated-DNA--[protein]-cysteine S-methyltransferase
PF14518 (3/3) Iron-containing redox enzyme
PF13535 (3/3) ATP-grasp domain
PF09859 (3/3) Oxygenase, catalysing oxidative methylation of damaged DNA
PF07859 (3/3) alpha/beta hydrolase fold
PF07690 (3/3) Major Facilitator Superfamily
PF06325 (3/3) Ribosomal protein L11 methyltransferase (PrmA)
PF01810 (3/3) LysE type translocator
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
PF02805 (2/3) Metal binding domain of Ada
jaccard_groups_571 78.34 +- 90.95 9 0 0 0 0.10 +- 0.07 9 2

PF08445 (9/9) FR47-like protein
PF00106 (5/9) short chain dehydrogenase
jaccard_groups_4977 62.53 +- 34.22 2 0 2 0 0.06 +- 0.07 2 4

PF08241 (2/2) Methyltransferase domain
PF00294 (2/2) pfkB family carbohydrate kinase
PF08922 (1/2) Domain of unknown function (DUF1905)
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
jaccard_groups_573 13.88 +- 2.98 2 0 0 0 0.21 +- 0.37 2 14

PF13560 (2/2) Helix-turn-helix domain
PF10901 (2/2) Protein of unknown function (DUF2690)
TIGR01759 (1/2) malate dehydrogenase
TIGR00127 (1/2) isocitrate dehydrogenase, NADP-dependent
PF11222 (1/2) Protein of unknown function (DUF3017)
PF07730 (1/2) Histidine kinase
PF02882 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF02866 (1/2) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00763 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00072 (1/2) Response regulator receiver domain
PF00056 (1/2) lactate/malate dehydrogenase, NAD binding domain
jaccard_groups_576 45.42 +- 24.89 16 0 0 0 0.11 +- 0.20 16 7

TIGR00254 (14/16) diguanylate cyclase (GGDEF) domain
PF12728 (14/16) Helix-turn-helix domain
PF00990 (14/16) Diguanylate cyclase, GGDEF domain
PF00589 (14/16) Phage integrase family
PF09250 (12/16) Bifunctional DNA primase/polymerase, N-terminal
TIGR01764 (8/16) DNA binding domain, excisionase family
PF10935 (8/16) Protein of unknown function (DUF2637)
jaccard_groups_3291 1308.92 +- 1084.30 7 0 7 7 0.03 +- 0.09 7 14

TIGR01733 (7/7) amino acid adenylation domain
TIGR01536 (7/7) asparagine synthase (glutamine-hydrolyzing)
PF18130 (7/7) ATP-grasp N-terminal domain
PF13537 (7/7) Glutamine amidotransferase domain
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF07690 (7/7) Major Facilitator Superfamily
PF03547 (7/7) Membrane transport protein
PF02668 (7/7) Taurine catabolism dioxygenase TauD, TfdA family
PF01063 (7/7) Amino-transferase class IV
PF00733 (7/7) Asparagine synthase
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00144 (7/7) Beta-lactamase
jaccard_groups_3293 10.79 +- 1.50 2 0 2 0 0.19 +- 0.11 2 3

PF03707 (2/2) Bacterial signalling protein N terminal repeat
PF00296 (2/2) Luciferase-like monooxygenase
PF00149 (2/2) Calcineurin-like phosphoesterase
jaccard_groups_3295 175.68 +- 210.03 4 0 0 0 0.09 +- 0.23 4 10

PF17668 (4/4) Acetyltransferase (GNAT) domain
PF13530 (4/4) Sterol carrier protein domain
PF13527 (4/4) Acetyltransferase (GNAT) domain
PF12821 (4/4) Threonine/Serine exporter, ThrE
PF06738 (4/4) Putative threonine/serine exporter
PF00877 (4/4) NlpC/P60 family
PF13589 (2/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13302 (2/4) Acetyltransferase (GNAT) domain
PF09335 (2/4) SNARE associated Golgi protein
PF00183 (2/4) Hsp90 protein
jaccard_groups_3297 235.34 +- 95.94 7 0 0 0 0.03 +- 0.06 7 8

TIGR01324 (7/7) cystathionine beta-lyase
PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF13535 (7/7) ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02786 (7/7) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01053 (7/7) Cys/Met metabolism PLP-dependent enzyme
PF00581 (7/7) Rhodanese-like domain
PF13229 (4/7) Right handed beta helix region
jaccard_groups_3299 97.23 +- 41.64 4 0 3 0 0.18 +- 0.31 4 34

TIGR01181 (4/4) dTDP-glucose 4,6-dehydratase
TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16363 (4/4) GDP-mannose 4,6 dehydratase
PF13191 (4/4) AAA ATPase domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (4/4) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00483 (4/4) Nucleotidyl transferase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
TIGR01207 (3/4) glucose-1-phosphate thymidylyltransferase
PF16197 (3/4) Ketoacyl-synthetase C-terminal extension
PF02801 (3/4) Beta-ketoacyl synthase, C-terminal domain
PF00109 (3/4) Beta-ketoacyl synthase, N-terminal domain
TIGR04516 (2/4) glycosyltransferase, activator-dependent family
PF18605 (2/4) Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain
PF18369 (2/4) Polyketide synthase dimerisation element domain
PF14765 (2/4) Polyketide synthase dehydratase
PF08990 (2/4) Erythronolide synthase docking
PF08659 (2/4) KR domain
PF07730 (2/4) Histidine kinase
PF06722 (2/4) Protein of unknown function (DUF1205)
PF03559 (2/4) NDP-hexose 2,3-dehydratase
PF02518 (2/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01370 (2/4) NAD dependent epimerase/dehydratase family
PF01061 (2/4) ABC-2 type transporter
PF00975 (2/4) Thioesterase domain
PF00908 (2/4) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/4) Acyl transferase domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00248 (2/4) Aldo/keto reductase family
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00072 (2/4) Response regulator receiver domain
PF00005 (2/4) ABC transporter
jaccard_groups_3298 26.76 +- 10.80 5 0 5 0 0.18 +- 0.37 5 6

TIGR01751 (5/5) crotonyl-CoA carboxylase/reductase
PF11236 (5/5) Protein of unknown function (DUF3037)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF00107 (5/5) Zinc-binding dehydrogenase
PF00067 (5/5) Cytochrome P450
jaccard_groups_4575 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_372 181.35 +- 99.08 4 0 0 0 0.04 +- 0.09 4 4

PF03861 (4/4) ANTAR domain
PF13631 (3/4) Cytochrome b(N-terminal)/b6/petB
PF13466 (3/4) STAS domain
PF01590 (3/4) GAF domain
jaccard_groups_370 324.00 +- 66.00 2 0 1 0 0.01 +- 0.00 2 6

PF13560 (2/2) Helix-turn-helix domain
PF06114 (2/2) IrrE N-terminal-like domain
PF18860 (1/2) AbiJ N-terminal domain 3
PF05621 (1/2) Bacterial TniB protein
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
jaccard_groups_371 73.46 +- 81.53 7 0 0 0 0.08 +- 0.09 7 1

PF07681 (7/7) DoxX
jaccard_groups_376 21.43 +- 11.92 37 0 7 0 0.18 +- 0.26 37 12

PF06386 (37/37) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (37/37) Gas vesicle synthesis protein GvpO
PF05121 (37/37) Gas vesicle protein K
PF05120 (37/37) Gas vesicle protein G
PF00741 (37/37) Gas vesicle protein
PF03364 (35/37) Polyketide cyclase / dehydrase and lipid transport
PF17657 (23/37) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (23/37) Helix-hairpin-helix motif
PF07733 (23/37) Bacterial DNA polymerase III alpha NTPase domain
PF02811 (23/37) PHP domain
TIGR00594 (22/37) DNA polymerase III, alpha subunit
PF00817 (22/37) impB/mucB/samB family
jaccard_groups_374 39.40 +- 57.74 5 0 1 0 0.15 +- 0.10 5 1

PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
jaccard_groups_375 67.89 +- 53.88 3 0 0 0 0.18 +- 0.27 3 9

PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
TIGR01235 (2/3) pyruvate carboxylase
PF07690 (2/3) Major Facilitator Superfamily
PF04248 (2/3) Domain of unknown function (DUF427)
PF02436 (2/3) Conserved carboxylase domain
PF00682 (2/3) HMGL-like
jaccard_groups_378 171.41 +- 149.21 11 0 2 0 0.04 +- 0.05 11 1

PF07859 (11/11) alpha/beta hydrolase fold
jaccard_groups_379 36.36 +- 0.78 2 0 0 0 0.06 +- 0.06 2 3

PF01925 (2/2) Sulfite exporter TauE/SafE
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
jaccard_groups_418 187.29 +- 136.42 20 0 6 0 0.04 +- 0.06 20 2

PF08031 (20/20) Berberine and berberine like
PF01565 (20/20) FAD binding domain
jaccard_groups_416 37.07 +- 4.24 3 0 0 0 0.05 +- 0.02 3 1

PF03771 (3/3) Domain of unknown function (DUF317)
jaccard_groups_413 163.02 +- 130.52 21 0 1 0 0.03 +- 0.04 21 3

PF02838 (21/21) Glycosyl hydrolase family 20, domain 2
PF00728 (21/21) Glycosyl hydrolase family 20, catalytic domain
PF01120 (16/21) Alpha-L-fucosidase
jaccard_groups_3071 71.84 +- 29.40 8 0 1 0 0.19 +- 0.31 8 7

PF05995 (8/8) Cysteine dioxygenase type I
PF04069 (8/8) Substrate binding domain of ABC-type glycine betaine transport system
PF00581 (8/8) Rhodanese-like domain
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF02018 (4/8) Carbohydrate binding domain
PF00704 (4/8) Glycosyl hydrolases family 18
jaccard_groups_6027 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
jaccard_groups_6021 486.38 +- 377.36 2 0 0 0 0.04 +- 0.11 2 11

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00248 (2/2) Aldo/keto reductase family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF00892 (1/2) EamA-like transporter family
PF00485 (1/2) Phosphoribulokinase / Uridine kinase family
PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_6532 630.67 +- 401.33 2 0 2 0 0.02 +- 0.01 2 5

PF08241 (2/2) Methyltransferase domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03795 (2/2) YCII-related domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (2/2) Condensation domain
jaccard_groups_6158 46.67 +- 0.00 2 0 1 0 0.09 +- 0.11 2 5

PF12146 (2/2) Serine aminopeptidase, S33
PF11338 (2/2) Protein of unknown function (DUF3140)
PF04909 (2/2) Amidohydrolase
PF04672 (2/2) S-adenosyl methyltransferase
PF01471 (2/2) Putative peptidoglycan binding domain
jaccard_groups_3452 36.10 +- 11.29 2 0 0 2 0.13 +- 0.14 2 12

TIGR03104 (2/2) asparagine synthase family amidotransferase
TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13537 (2/2) Glutamine amidotransferase domain
PF13466 (2/2) STAS domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00733 (2/2) Asparagine synthase
PF00326 (2/2) Prolyl oligopeptidase family
TIGR02050 (1/2) carboxylate-amine ligase, YbdK family
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
jaccard_groups_2108 101.38 +- 64.90 2 0 0 0 0.08 +- 0.21 2 10

TIGR00369 (2/2) uncharacterized domain 1
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03061 (2/2) Thioesterase superfamily
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
jaccard_groups_2106 795.34 +- 419.09 10 0 10 0 0.02 +- 0.03 10 26

TIGR01733 (10/10) amino acid adenylation domain
PF13714 (10/10) Phosphoenolpyruvate phosphomutase
PF13434 (10/10) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (10/10) Acetyltransferase (GNAT) domain
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF09334 (10/10) tRNA synthetases class I (M)
PF07883 (10/10) Cupin domain
PF01266 (10/10) FAD dependent oxidoreductase
PF00975 (10/10) Thioesterase domain
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF16653 (9/10) Saccharopine dehydrogenase C-terminal domain
PF14518 (9/10) Iron-containing redox enzyme
PF13535 (9/10) ATP-grasp domain
PF08545 (9/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07690 (9/10) Major Facilitator Superfamily
PF03435 (9/10) Saccharopine dehydrogenase NADP binding domain
PF03417 (9/10) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (9/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/10) Acyl-CoA dehydrogenase, middle domain
PF00441 (9/10) Acyl-CoA dehydrogenase, C-terminal domain
PF05222 (8/10) Alanine dehydrogenase/PNT, N-terminal domain
PF01648 (7/10) 4'-phosphopantetheinyl transferase superfamily
PF18563 (6/10) TubC N-terminal docking domain
PF00067 (6/10) Cytochrome P450
jaccard_groups_4730 915.56 +- 502.62 2 0 0 0 0.01 +- 0.01 2 8

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_6155 176.10 +- 23.90 2 0 0 0 0.02 +- 0.02 2 11

TIGR04267 (2/2) HEXXH motif domain
PF08007 (2/2) Cupin superfamily protein
PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF03466 (2/2) LysR substrate binding domain
PF01523 (2/2) Putative modulator of DNA gyrase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF12158 (1/2) Protein of unknown function (DUF3592)
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02310 (1/2) B12 binding domain
jaccard_groups_702 18.74 +- 7.57 3 0 1 0 0.18 +- 0.13 3 2

TIGR01413 (3/3) Dyp-type peroxidase family
PF04261 (3/3) Dyp-type peroxidase family
jaccard_groups_701 308.65 +- 175.23 3 0 0 0 0.04 +- 0.06 3 5

TIGR02960 (3/3) RNA polymerase sigma-70 factor, TIGR02960 family
PF12680 (3/3) SnoaL-like domain
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF01872 (2/3) RibD C-terminal domain
jaccard_groups_3677 96.86 +- 115.38 3 0 2 0 0.12 +- 0.20 3 4

PF07690 (3/3) Major Facilitator Superfamily
PF04672 (3/3) S-adenosyl methyltransferase
PF00149 (3/3) Calcineurin-like phosphoesterase
PF00754 (2/3) F5/8 type C domain
jaccard_groups_533 46.55 +- 28.88 5 0 0 0 0.08 +- 0.09 5 1

PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase
jaccard_groups_6441 164.86 +- 47.86 2 0 0 0 0.04 +- 0.02 2 5

TIGR00784 (2/2) citrate transporter
PF18435 (2/2) Esterase Ig-like N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF03600 (2/2) Citrate transporter
PF00135 (2/2) Carboxylesterase family
jaccard_groups_6440 103.66 +- 11.52 2 0 0 0 0.04 +- 0.07 2 10

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF01614 (2/2) Bacterial transcriptional regulator
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00501 (1/2) AMP-binding enzyme
PF00175 (1/2) Oxidoreductase NAD-binding domain
jaccard_groups_6447 38.62 +- 15.17 2 0 0 0 0.06 +- 0.10 2 5

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF14016 (2/2) Protein of unknown function (DUF4232)
PF12840 (2/2) Helix-turn-helix domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_2070 44.67 +- 21.40 7 0 6 0 0.08 +- 0.16 7 5

PF13454 (7/7) FAD-NAD(P)-binding
PF10397 (7/7) Adenylosuccinate lyase C-terminus
PF00206 (7/7) Lyase
TIGR02426 (5/7) 3-carboxy-cis,cis-muconate cycloisomerase
PF13714 (4/7) Phosphoenolpyruvate phosphomutase
jaccard_groups_2074 23.69 +- 9.14 9 0 0 0 0.18 +- 0.22 9 10

TIGR00630 (9/9) excinuclease ABC subunit A
PF17755 (9/9) UvrA DNA-binding domain
PF14759 (9/9) Reductase C-terminal
PF13499 (9/9) EF-hand domain pair
PF13370 (9/9) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (9/9) Pyridine nucleotide-disulphide oxidoreductase
PF00005 (8/9) ABC transporter
PF13305 (5/9) Tetracyclin repressor-like, C-terminal domain
PF00440 (5/9) Bacterial regulatory proteins, tetR family
PF00067 (5/9) Cytochrome P450
jaccard_groups_2816 219.82 +- 189.35 10 0 1 0 0.06 +- 0.20 10 12

TIGR02170 (10/10) thymidylate synthase, flavin-dependent
TIGR00730 (10/10) TIGR00730 family protein
PF18603 (10/10) L-amino acid ligase C-terminal domain 2
PF14226 (10/10) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (10/10) ATP-grasp domain
PF03641 (10/10) Possible lysine decarboxylase
PF03171 (10/10) 2OG-Fe(II) oxygenase superfamily
PF02511 (10/10) Thymidylate synthase complementing protein
PF00860 (8/10) Permease family
PF18130 (5/10) ATP-grasp N-terminal domain
PF07690 (5/10) Major Facilitator Superfamily
PF02655 (5/10) ATP-grasp domain
jaccard_groups_2817 480.95 +- 234.80 7 0 3 7 0.02 +- 0.02 7 10

TIGR04469 (7/7) CGA synthase-related protein
TIGR04468 (7/7) arginine 2,3-aminomutase
TIGR04467 (7/7) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (7/7) cytosylglucuronate decarboxylase
PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF08241 (7/7) Methyltransferase domain
PF04055 (7/7) Radical SAM superfamily
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF07690 (5/7) Major Facilitator Superfamily
PF05014 (4/7) Nucleoside 2-deoxyribosyltransferase
jaccard_groups_2810 79.74 +- 50.26 2 0 0 0 0.05 +- 0.07 2 4

PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF16483 (1/2) Beta-1,3-glucanase
PF01261 (1/2) Xylose isomerase-like TIM barrel
jaccard_groups_5721 147.51 +- 75.70 2 0 1 0 0.07 +- 0.11 2 10

PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF07350 (2/2) Protein of unknown function (DUF1479)
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03576 (2/2) Peptidase family S58
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_5859 28.15 +- 5.04 2 0 0 0 0.11 +- 0.07 2 3

PF13489 (2/2) Methyltransferase domain
PF05685 (2/2) Putative restriction endonuclease
PF02082 (2/2) Transcriptional regulator
jaccard_groups_5850 977.21 +- 452.79 2 0 2 2 0.01 +- 0.02 2 25

TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (2/2) mycofactocin precursor
TIGR03967 (2/2) putative mycofactocin binding protein MftB
TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (2/2) mycofactocin system glycosyltransferase
TIGR03964 (2/2) mycofactocin system creatininase family protein
TIGR03962 (2/2) mycofactocin radical SAM maturase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF08242 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF03129 (2/2) Anticodon binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF01070 (2/2) FMN-dependent dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00535 (2/2) Glycosyl transferase family 2
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
jaccard_groups_5853 323.75 +- 1.25 2 0 0 0 0.01 +- 0.01 2 7

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07690 (2/2) Major Facilitator Superfamily
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_5852 46.28 +- 31.16 2 0 0 0 0.11 +- 0.18 2 12

PF17668 (2/2) Acetyltransferase (GNAT) domain
PF13530 (2/2) Sterol carrier protein domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF07730 (2/2) Histidine kinase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF12680 (1/2) SnoaL-like domain
PF07366 (1/2) SnoaL-like polyketide cyclase
PF01661 (1/2) Macro domain
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_5854 141.85 +- 82.86 2 0 2 0 0.10 +- 0.09 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00664 (2/2) ABC transporter transmembrane region
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
jaccard_groups_5726 118.89 +- 102.25 2 0 2 0 0.06 +- 0.18 2 4

PF17195 (2/2) Protein of unknown function (DUF5132)
PF12697 (2/2) Alpha/beta hydrolase family
PF05960 (2/2) Bacterial protein of unknown function (DUF885)
PF00975 (2/2) Thioesterase domain
jaccard_groups_3702 347.82 +- 250.44 5 0 2 0 0.06 +- 0.14 5 16

TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR00802 (5/5) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (5/5) GYF domain 2
PF13421 (5/5) SPFH domain-Band 7 family
PF07690 (5/5) Major Facilitator Superfamily
PF04314 (5/5) Copper chaperone PCu(A)C
PF03824 (5/5) High-affinity nickel-transport protein
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF13738 (4/5) Pyridine nucleotide-disulphide oxidoreductase
PF08281 (4/5) Sigma-70, region 4
PF04542 (4/5) Sigma-70 region 2
PF01070 (4/5) FMN-dependent dehydrogenase
PF00067 (4/5) Cytochrome P450
jaccard_groups_3701 72.64 +- 57.36 2 0 0 0 0.12 +- 0.19 2 4

PF08962 (2/2) Domain of unknown function (DUF1876)
PF01738 (2/2) Dienelactone hydrolase family
PF00156 (2/2) Phosphoribosyl transferase domain
PF09587 (1/2) Bacterial capsule synthesis protein PGA_cap
jaccard_groups_3700 32.13 +- 5.78 3 0 0 0 0.06 +- 0.11 3 6

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF08386 (3/3) TAP-like protein
PF04149 (3/3) Domain of unknown function (DUF397)
PF02388 (3/3) FemAB family
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_3707 984.29 +- 704.12 5 0 5 0 0.03 +- 0.12 5 18

TIGR01733 (5/5) amino acid adenylation domain
PF13302 (5/5) Acetyltransferase (GNAT) domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07993 (5/5) Male sterility protein
PF07690 (5/5) Major Facilitator Superfamily
PF03621 (5/5) MbtH-like protein
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/5) Acyl transferase domain
PF00668 (5/5) Condensation domain
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
PF13649 (4/5) Methyltransferase domain
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF01648 (4/5) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/5) Thioesterase domain
PF00196 (4/5) Bacterial regulatory proteins, luxR family
jaccard_groups_2652 1970.88 +- 2367.12 5 0 0 0 0.03 +- 0.04 5 14

TIGR01928 (5/5) o-succinylbenzoate synthase
PF13378 (5/5) Enolase C-terminal domain-like
PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00496 (5/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00144 (5/5) Beta-lactamase
PF00005 (5/5) ABC transporter
PF13556 (4/5) PucR C-terminal helix-turn-helix domain
PF08352 (4/5) Oligopeptide/dipeptide transporter, C-terminal region
PF07676 (4/5) WD40-like Beta Propeller Repeat
PF00326 (4/5) Prolyl oligopeptidase family
TIGR01727 (3/5) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17853 (3/5) GGDEF-like domain
PF01546 (3/5) Peptidase family M20/M25/M40
jaccard_groups_2653 135.33 +- 84.38 3 0 1 0 0.11 +- 0.29 3 5

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF13602 (2/3) Zinc-binding dehydrogenase
PF13191 (2/3) AAA ATPase domain
jaccard_groups_2650 134.23 +- 12.02 2 0 2 0 0.03 +- 0.03 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03109 (2/2) ABC1 family
PF00487 (2/2) Fatty acid desaturase
jaccard_groups_3708 57.11 +- 1.39 2 0 2 0 0.05 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05675 (2/2) Protein of unknown function (DUF817)
PF01810 (2/2) LysE type translocator
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00083 (2/2) Sugar (and other) transporter
jaccard_groups_4413 518.00 +- 2.00 4 0 0 0 0.01 +- 0.00 4 7

PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF05141 (4/4) Pyoverdine/dityrosine biosynthesis protein
PF04820 (4/4) Tryptophan halogenase
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01565 (4/4) FAD binding domain
TIGR01509 (3/4) HAD hydrolase, family IA, variant 3
jaccard_groups_2498 505.67 +- 195.77 12 0 0 0 0.02 +- 0.02 12 19

TIGR02124 (12/12) hydrogenase expression/formation protein HypE
TIGR00143 (12/12) carbamoyltransferase HypF
PF17788 (12/12) HypF Kae1-like domain
PF07503 (12/12) HypF finger
PF02769 (12/12) AIR synthase related protein, C-terminal domain
PF01300 (12/12) Telomere recombination
PF00708 (12/12) Acylphosphatase
PF00586 (12/12) AIR synthase related protein, N-terminal domain
TIGR01891 (10/12) amidohydrolase
TIGR00709 (10/12) 2,4-diaminobutyrate 4-transaminase
PF13535 (10/12) ATP-grasp domain
PF12680 (10/12) SnoaL-like domain
PF07690 (10/12) Major Facilitator Superfamily
PF05977 (10/12) Transmembrane secretion effector
PF01546 (10/12) Peptidase family M20/M25/M40
PF00857 (10/12) Isochorismatase family
PF00202 (10/12) Aminotransferase class-III
PF00155 (10/12) Aminotransferase class I and II
PF00583 (9/12) Acetyltransferase (GNAT) family
jaccard_groups_2490 330.06 +- 319.94 2 0 0 0 0.07 +- 0.12 2 7

PF08241 (2/2) Methyltransferase domain
PF01329 (2/2) Pterin 4 alpha carbinolamine dehydratase
PF18370 (1/2) Rhamnogalacturonan I lyases beta-sheet domain
PF13649 (1/2) Methyltransferase domain
PF03747 (1/2) ADP-ribosylglycohydrolase
PF01341 (1/2) Glycosyl hydrolases family 6
PF00553 (1/2) Cellulose binding domain
jaccard_groups_2495 293.72 +- 222.28 2 0 1 0 0.05 +- 0.05 2 12

TIGR02262 (2/2) benzoate-CoA ligase family
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF04299 (1/2) Putative FMN-binding domain
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01063 (1/2) Amino-transferase class IV
jaccard_groups_2496 154.42 +- 117.56 13 0 2 0 0.15 +- 0.08 13 18

PF14310 (13/13) Fibronectin type III-like domain
PF13377 (13/13) Periplasmic binding protein-like domain
PF01915 (13/13) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (13/13) Bacterial extracellular solute-binding protein
PF00933 (13/13) Glycosyl hydrolase family 3 N terminal domain
PF00528 (13/13) Binding-protein-dependent transport system inner membrane component
PF00356 (13/13) Bacterial regulatory proteins, lacI family
PF00150 (13/13) Cellulase (glycosyl hydrolase family 5)
PF09084 (10/13) NMT1/THI5 like
PF00753 (10/13) Metallo-beta-lactamase superfamily
PF00135 (10/13) Carboxylesterase family
PF00005 (10/13) ABC transporter
PF16197 (7/13) Ketoacyl-synthetase C-terminal extension
PF02801 (7/13) Beta-ketoacyl synthase, C-terminal domain
PF01370 (7/13) NAD dependent epimerase/dehydratase family
PF00155 (7/13) Aminotransferase class I and II
PF00109 (7/13) Beta-ketoacyl synthase, N-terminal domain
PF00067 (7/13) Cytochrome P450
jaccard_groups_2256 156.05 +- 57.99 6 0 0 0 0.02 +- 0.02 6 2

PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent
PF02600 (6/6) Disulfide bond formation protein DsbB
jaccard_groups_5928 129.59 +- 16.48 2 0 0 0 0.17 +- 0.16 2 8

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_5925 81.71 +- 56.95 2 0 0 0 0.10 +- 0.11 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF11239 (2/2) Protein of unknown function (DUF3040)
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
jaccard_groups_6183 177.75 +- 80.25 2 0 0 0 0.02 +- 0.03 2 6

PF03777 (2/2) ChpA-C
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13285 (1/2) Domain of unknown function (DUF4073)
PF00149 (1/2) Calcineurin-like phosphoesterase
jaccard_groups_459 219.14 +- 126.01 19 0 5 0 0.03 +- 0.07 19 4

PF13459 (19/19) 4Fe-4S single cluster domain
PF10589 (19/19) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF01512 (19/19) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF03640 (13/19) Secreted repeat of unknown function
jaccard_groups_753 19.78 +- 4.79 4 0 2 0 0.11 +- 0.09 4 3

PF13564 (4/4) DoxX-like family
PF07883 (4/4) Cupin domain
PF00652 (3/4) Ricin-type beta-trefoil lectin domain
jaccard_groups_754 136.05 +- 123.95 2 0 2 0 0.06 +- 0.12 2 5

PF00975 (2/2) Thioesterase domain
PF13191 (1/2) AAA ATPase domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF00067 (1/2) Cytochrome P450
jaccard_groups_755 191.21 +- 102.82 5 0 3 0 0.04 +- 0.10 5 5

PF03764 (5/5) Elongation factor G, domain IV
PF00679 (5/5) Elongation factor G C-terminus
PF00009 (5/5) Elongation factor Tu GTP binding domain
TIGR00231 (4/5) small GTP-binding protein domain
PF14492 (4/5) Elongation Factor G, domain II
jaccard_groups_5705 106.50 +- 54.15 2 0 2 0 0.07 +- 0.21 2 10

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF13469 (2/2) Sulfotransferase family
PF12848 (2/2) ABC transporter
PF07883 (2/2) Cupin domain
PF07730 (2/2) Histidine kinase
PF04672 (2/2) S-adenosyl methyltransferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
jaccard_groups_5702 614.31 +- 165.69 2 0 0 0 0.02 +- 0.07 2 13

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF13649 (2/2) Methyltransferase domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07398 (2/2) MDMPI C-terminal domain
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00303 (2/2) Thymidylate synthase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (1/2) Acyl-CoA oxidase
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_5630 520.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03551 (2/2) Transcriptional regulator PadR-like family
PF03070 (2/2) TENA/THI-4/PQQC family
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
jaccard_groups_5632 456.88 +- 26.88 2 0 0 0 0.01 +- 0.01 2 6

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01756 (2/2) Acyl-CoA oxidase
PF00698 (2/2) Acyl transferase domain
PF00296 (2/2) Luciferase-like monooxygenase
jaccard_groups_5635 720.96 +- 53.62 2 0 0 0 0.02 +- 0.00 2 11

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01425 (2/2) Amidase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR02713 (1/2) allophanate hydrolase
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF00455 (1/2) DeoR C terminal sensor domain
jaccard_groups_960 278.00 +- 238.00 2 0 0 0 0.04 +- 0.04 2 3

PF09587 (2/2) Bacterial capsule synthesis protein PGA_cap
PF01522 (1/2) Polysaccharide deacetylase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1358 28.24 +- 20.81 7 0 4 0 0.18 +- 0.17 7 7

PF13977 (7/7) BetI-type transcriptional repressor, C-terminal
PF13279 (7/7) Thioesterase-like superfamily
PF05853 (7/7) beta-keto acid cleavage enzyme
PF02737 (7/7) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (7/7) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00440 (7/7) Bacterial regulatory proteins, tetR family
PF07690 (4/7) Major Facilitator Superfamily
jaccard_groups_1359 147.63 +- 92.15 6 0 1 0 0.03 +- 0.03 6 4

PF02927 (6/6) Cellulase N-terminal ig-like domain
PF02018 (6/6) Carbohydrate binding domain
PF00759 (6/6) Glycosyl hydrolase family 9
PF01341 (4/6) Glycosyl hydrolases family 6
jaccard_groups_5147 112.46 +- 23.39 3 0 0 0 0.02 +- 0.01 3 3

PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF04229 (3/3) GrpB protein
PF01979 (3/3) Amidohydrolase family
jaccard_groups_5146 72.50 +- 12.83 2 0 0 0 0.17 +- 0.30 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00630 (2/2) excinuclease ABC subunit A
PF17760 (2/2) UvrA interaction domain
PF17755 (2/2) UvrA DNA-binding domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13280 (2/2) WYL domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF00140 (2/2) Sigma-70 factor, region 1.2
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
jaccard_groups_1354 278.88 +- 259.29 7 0 1 0 0.04 +- 0.05 7 2

PF12697 (7/7) Alpha/beta hydrolase family
PF01494 (7/7) FAD binding domain
jaccard_groups_5143 21.63 +- 4.99 2 0 0 0 0.23 +- 0.33 2 16

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR01411 (2/2) twin arginine-targeting protein translocase, TatA/E family
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02416 (2/2) mttA/Hcf106 family
PF02342 (2/2) TerD domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01524 (1/2) magnesium-translocating P-type ATPase
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00690 (1/2) Cation transporter/ATPase, N-terminus
PF00689 (1/2) Cation transporting ATPase, C-terminus
PF00122 (1/2) E1-E2 ATPase
jaccard_groups_5142 714.16 +- 458.33 3 0 3 0 0.04 +- 0.17 3 12

TIGR00710 (3/3) drug resistance transporter, Bcr/CflA subfamily
PF13460 (3/3) NAD(P)H-binding
PF13454 (3/3) FAD-NAD(P)-binding
PF11794 (3/3) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF07690 (3/3) Major Facilitator Superfamily
PF03241 (3/3) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (3/3) Flavin reductase like domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF13434 (2/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF00126 (2/3) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1350 294.21 +- 46.07 6 0 2 2 0.01 +- 0.00 6 3

PF16861 (6/6) Carbamoyltransferase C-terminus
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00106 (3/6) short chain dehydrogenase
jaccard_groups_5140 593.67 +- 316.01 3 0 0 0 0.01 +- 0.00 3 6

PF13483 (3/3) Beta-lactamase superfamily domain
PF09037 (3/3) Stf0 sulphotransferase
PF07690 (3/3) Major Facilitator Superfamily
PF00248 (3/3) Aldo/keto reductase family
PF13671 (2/3) AAA domain
PF12697 (2/3) Alpha/beta hydrolase family
jaccard_groups_3139 526.52 +- 159.88 2 0 2 0 0.02 +- 0.01 2 15

TIGR00977 (2/2) citramalate synthase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08502 (2/2) LeuA allosteric (dimerisation) domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00682 (2/2) HMGL-like
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07690 (1/2) Major Facilitator Superfamily
PF02515 (1/2) CoA-transferase family III
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_2736 196.70 +- 105.11 8 0 0 7 0.07 +- 0.12 8 16

TIGR04283 (8/8) transferase 2, rSAM/selenodomain-associated
TIGR04282 (8/8) transferase 1, rSAM/selenodomain-associated
PF09837 (8/8) Uncharacterized protein conserved in bacteria (DUF2064)
PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (8/8) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01048 (8/8) Phosphorylase superfamily
PF00535 (8/8) Glycosyl transferase family 2
PF12850 (7/8) Calcineurin-like phosphoesterase superfamily domain
PF04055 (7/8) Radical SAM superfamily
PF07291 (5/8) Methylamine utilisation protein MauE
PF02687 (5/8) FtsX-like permease family
PF00005 (5/8) ABC transporter
PF00672 (4/8) HAMP domain
PF00512 (4/8) His Kinase A (phospho-acceptor) domain
PF00486 (4/8) Transcriptional regulatory protein, C terminal
PF00072 (4/8) Response regulator receiver domain
jaccard_groups_6506 1498.58 +- 93.92 2 0 2 0 0.01 +- 0.00 2 16

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03795 (2/2) YCII-related domain
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01738 (2/2) Dienelactone hydrolase family
PF00890 (2/2) FAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1285 122.25 +- 83.36 15 0 0 0 0.05 +- 0.05 15 6

PF00667 (15/15) FAD binding domain
PF00258 (15/15) Flavodoxin
PF00067 (15/15) Cytochrome P450
PF00175 (14/15) Oxidoreductase NAD-binding domain
PF00107 (9/15) Zinc-binding dehydrogenase
PF08240 (8/15) Alcohol dehydrogenase GroES-like domain
jaccard_groups_1286 98.05 +- 62.22 11 0 2 0 0.06 +- 0.06 11 3

PF18368 (11/11) Exo-beta-D-glucosaminidase Ig-fold domain
PF00703 (10/11) Glycosyl hydrolases family 2
PF07166 (7/11) Protein of unknown function (DUF1398)
jaccard_groups_1280 21.20 +- 15.51 4 0 1 0 0.20 +- 0.32 4 9

PF02540 (4/4) NAD synthase
PF00795 (4/4) Carbon-nitrogen hydrolase
TIGR00552 (3/4) NAD+ synthetase
PF11303 (2/4) Protein of unknown function (DUF3105)
PF07732 (2/4) Multicopper oxidase
PF07731 (2/4) Multicopper oxidase
PF03713 (2/4) Domain of unknown function (DUF305)
PF00571 (2/4) CBS domain
PF00394 (2/4) Multicopper oxidase
jaccard_groups_1282 57.99 +- 0.06 2 0 2 0 0.09 +- 0.06 2 13

TIGR02159 (2/2) phenylacetate-CoA oxygenase, PaaJ subunit
TIGR02158 (2/2) phenylacetate-CoA oxygenase, PaaI subunit
TIGR02157 (2/2) phenylacetate-CoA oxygenase, PaaH subunit
TIGR02156 (2/2) phenylacetate-CoA oxygenase, PaaG subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF06243 (2/2) Phenylacetic acid degradation B
PF05138 (2/2) Phenylacetic acid catabolic protein
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF01883 (2/2) Iron-sulfur cluster assembly protein
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_1283 186.43 +- 217.84 9 0 0 0 0.10 +- 0.15 9 3

PF07690 (9/9) Major Facilitator Superfamily
PF00903 (8/9) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF04185 (6/9) Phosphoesterase family
jaccard_groups_1757 228.96 +- 232.71 22 0 21 0 0.07 +- 0.18 22 14

PF00501 (22/22) AMP-binding enzyme
PF13193 (21/22) AMP-binding enzyme C-terminal domain
PF07690 (18/22) Major Facilitator Superfamily
PF00550 (18/22) Phosphopantetheine attachment site
PF02776 (16/22) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (16/22) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (16/22) Thiamine pyrophosphate enzyme, central domain
PF00155 (16/22) Aminotransferase class I and II
PF00171 (15/22) Aldehyde dehydrogenase family
TIGR00517 (13/22) acyl carrier protein
PF13561 (13/22) Enoyl-(Acyl carrier protein) reductase
PF02801 (13/22) Beta-ketoacyl synthase, C-terminal domain
PF00109 (13/22) Beta-ketoacyl synthase, N-terminal domain
PF00668 (12/22) Condensation domain
jaccard_groups_1758 210.88 +- 138.39 3 0 1 0 0.04 +- 0.09 3 13

PF13581 (3/3) Histidine kinase-like ATPase domain
PF13466 (3/3) STAS domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00072 (3/3) Response regulator receiver domain
TIGR00377 (2/3) anti-anti-sigma factor
TIGR00229 (2/3) PAS domain S-box protein
PF13185 (2/3) GAF domain
PF08448 (2/3) PAS fold
PF03793 (2/3) PASTA domain
PF01740 (2/3) STAS domain
PF00989 (2/3) PAS fold
jaccard_groups_149 322.37 +- 256.65 10 0 4 3 0.02 +- 0.03 10 1

PF01135 (10/10) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
jaccard_groups_2927 595.72 +- 118.35 4 0 4 0 0.01 +- 0.02 4 9

TIGR01250 (4/4) proline-specific peptidase
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (4/4) Methylaspartate mutase E chain (MutE)
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (4/4) B12 binding domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00067 (4/4) Cytochrome P450
jaccard_groups_140 182.06 +- 161.94 2 0 1 0 0.13 +- 0.20 2 8

PF03551 (2/2) Transcriptional regulator PadR-like family
PF17042 (1/2) Nucleotide-binding C-terminal domain
PF10400 (1/2) Virulence activator alpha C-term
PF07005 (1/2) Sugar-binding N-terminal domain
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02698 (1/2) DUF218 domain
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_143 116.91 +- 99.55 4 0 0 0 0.06 +- 0.10 4 3

PF00155 (4/4) Aminotransferase class I and II
PF01148 (2/4) Cytidylyltransferase family
PF00392 (2/4) Bacterial regulatory proteins, gntR family
jaccard_groups_142 88.15 +- 91.58 16 0 0 0 0.09 +- 0.18 16 1

PF04978 (16/16) Protein of unknown function (DUF664)
jaccard_groups_145 367.84 +- 492.87 42 0 7 0 0.10 +- 0.17 42 3

PF02653 (42/42) Branched-chain amino acid transport system / permease component
PF13407 (41/42) Periplasmic binding protein domain
PF00005 (40/42) ABC transporter
jaccard_groups_144 150.66 +- 164.14 30 0 8 0 0.07 +- 0.15 30 4

PF00005 (30/30) ABC transporter
PF12704 (29/30) MacB-like periplasmic core domain
PF02687 (29/30) FtsX-like permease family
PF01471 (25/30) Putative peptidoglycan binding domain
jaccard_groups_146 149.43 +- 112.57 11 0 1 0 0.06 +- 0.13 11 2

PF00534 (11/11) Glycosyl transferases group 1
PF13439 (7/11) Glycosyltransferase Family 4
jaccard_groups_389 33.09 +- 8.71 3 0 0 0 0.11 +- 0.22 3 20

TIGR02548 (3/3) CRISPR type I-E/ECOLI-associated protein CasB/Cse2
TIGR02547 (3/3) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
TIGR01907 (3/3) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
TIGR01873 (3/3) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
TIGR01869 (3/3) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
TIGR01868 (3/3) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
TIGR01596 (3/3) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (3/3) CRISPR-associated helicase Cas3
PF18395 (3/3) Cas3 C-terminal domain
PF18019 (3/3) HD domain
PF09707 (3/3) CRISPR-associated protein (Cas_Cas2CT1978)
PF09704 (3/3) CRISPR-associated protein (Cas_Cas5)
PF09485 (3/3) CRISPR-associated protein Cse2 (CRISPR_cse2)
PF09481 (3/3) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF09344 (3/3) CT1975-like protein
PF08798 (3/3) CRISPR associated protein
TIGR03638 (2/3) CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI
PF07876 (2/3) Stress responsive A/B Barrel Domain
PF05685 (2/3) Putative restriction endonuclease
PF01867 (2/3) CRISPR associated protein Cas1
jaccard_groups_384 229.87 +- 188.98 6 0 1 0 0.05 +- 0.06 6 1

PF00857 (6/6) Isochorismatase family
jaccard_groups_4149 75.88 +- 0.00 2 0 0 2 0.07 +- 0.07 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_1916 19.83 +- 7.04 4 0 0 0 0.20 +- 0.23 4 10

PF17677 (4/4) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF11975 (4/4) Family 4 glycosyl hydrolase C-terminal domain
PF09261 (4/4) Alpha mannosidase middle domain
PF07748 (4/4) Glycosyl hydrolases family 38 C-terminal domain
PF02056 (4/4) Family 4 glycosyl hydrolase
PF01074 (4/4) Glycosyl hydrolases family 38 N-terminal domain
PF01120 (3/4) Alpha-L-fucosidase
PF00455 (3/4) DeoR C terminal sensor domain
PF08220 (2/4) DeoR-like helix-turn-helix domain
PF07883 (2/4) Cupin domain
jaccard_groups_1910 353.86 +- 232.14 3 0 0 0 0.06 +- 0.10 3 3

PF11338 (3/3) Protein of unknown function (DUF3140)
PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF00857 (3/3) Isochorismatase family
jaccard_groups_1913 367.76 +- 549.27 8 0 1 0 0.03 +- 0.08 8 4

PF12450 (8/8) von Willebrand factor
PF12034 (8/8) Domain of unknown function (DUF3520)
PF00092 (8/8) von Willebrand factor type A domain
PF00501 (4/8) AMP-binding enzyme
jaccard_groups_4142 16.86 +- 7.90 2 0 0 0 0.19 +- 0.14 2 5

TIGR03666 (2/2) PPOX class probable F420-dependent enzyme, Rv2061 family
PF17124 (2/2) ThiJ/PfpI family-like
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00155 (2/2) Aminotransferase class I and II
PF06210 (1/2) Protein of unknown function (DUF1003)
jaccard_groups_4143 89.33 +- 31.49 3 0 0 0 0.19 +- 0.32 3 10

PF18844 (3/3) Bacterial archaeo-eukaryotic release factor family 2
PF13847 (3/3) Methyltransferase domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF11387 (3/3) Protein of unknown function (DUF2795)
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF01569 (3/3) PAP2 superfamily
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_4412 1302.34 +- 517.46 4 0 0 0 0.01 +- 0.01 4 17

TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF13183 (4/4) 4Fe-4S dicluster domain
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (4/4) FCD domain
PF03737 (4/4) Aldolase/RraA
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02754 (4/4) Cysteine-rich domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (4/4) FAD binding domain
PF01229 (4/4) Glycosyl hydrolases family 39
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
jaccard_groups_4145 93.10 +- 62.90 2 0 0 0 0.14 +- 0.31 2 6

PF17775 (2/2) UPF0225 domain
PF03098 (2/2) Animal haem peroxidase
PF00199 (2/2) Catalase
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF03777 (1/2) ChpA-C
PF01546 (1/2) Peptidase family M20/M25/M40
jaccard_groups_4410 1175.66 +- 1146.34 2 0 1 0 0.04 +- 0.16 2 12

TIGR03438 (2/2) dimethylhistidine N-methyltransferase
TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF12846 (1/2) AAA-like domain
PF12642 (1/2) Conjugative transposon protein TcpC
PF07510 (1/2) Protein of unknown function (DUF1524)
jaccard_groups_4411 47.62 +- 27.38 2 0 0 0 0.14 +- 0.28 2 7

TIGR00872 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF04199 (2/2) Putative cyclase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_1136 106.64 +- 88.36 2 0 1 0 0.09 +- 0.07 2 7

PF08453 (2/2) Peptidase family M9 N-terminal
PF01752 (2/2) Collagenase
PF08007 (1/2) Cupin superfamily protein
PF05544 (1/2) Proline racemase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF00067 (1/2) Cytochrome P450
jaccard_groups_4385 113.39 +- 34.95 4 0 0 0 0.06 +- 0.10 4 7

PF13581 (4/4) Histidine kinase-like ATPase domain
PF07690 (4/4) Major Facilitator Superfamily
PF07681 (4/4) DoxX
PF02515 (4/4) CoA-transferase family III
PF01546 (4/4) Peptidase family M20/M25/M40
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_4380 777.00 +- 3.00 4 0 0 4 0.01 +- 0.00 4 8

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
PF07690 (4/4) Major Facilitator Superfamily
PF03972 (4/4) MmgE/PrpD family
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00675 (4/4) Insulinase (Peptidase family M16)
PF16058 (3/4) Mucin-like
jaccard_groups_1139 61.98 +- 72.36 21 0 1 16 0.09 +- 0.10 21 3

PF02547 (21/21) Queuosine biosynthesis protein
PF00106 (21/21) short chain dehydrogenase
PF00881 (16/21) Nitroreductase family
jaccard_groups_4363 14.20 +- 0.52 2 0 0 2 0.21 +- 0.29 2 4

PF13360 (2/2) PQQ-like domain
PF06906 (2/2) Protein of unknown function (DUF1272)
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01329 (2/2) Pterin 4 alpha carbinolamine dehydratase
jaccard_groups_49 59.58 +- 80.36 29 0 0 0 0.12 +- 0.22 29 1

PF00877 (29/29) NlpC/P60 family
jaccard_groups_48 37.62 +- 21.12 3 0 1 0 0.13 +- 0.18 3 2

PF18029 (3/3) Glyoxalase-like domain
PF01243 (2/3) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_46 177.06 +- 114.69 21 0 5 0 0.04 +- 0.04 21 3

PF07729 (18/21) FCD domain
PF00392 (18/21) Bacterial regulatory proteins, gntR family
PF07690 (13/21) Major Facilitator Superfamily
jaccard_groups_45 182.72 +- 193.50 30 0 5 0 0.04 +- 0.08 30 1

PF01494 (30/30) FAD binding domain
jaccard_groups_44 83.84 +- 71.93 2 0 0 0 0.05 +- 0.08 2 7

PF00589 (2/2) Phage integrase family
PF14659 (1/2) Phage integrase, N-terminal SAM-like domain
PF13649 (1/2) Methyltransferase domain
PF13560 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF07883 (1/2) Cupin domain
PF00239 (1/2) Resolvase, N terminal domain
jaccard_groups_42 155.01 +- 225.42 124 0 27 0 0.09 +- 0.16 124 2

PF00501 (124/124) AMP-binding enzyme
PF13193 (120/124) AMP-binding enzyme C-terminal domain
jaccard_groups_1629 132.24 +- 60.65 33 0 1 0 0.12 +- 0.14 33 15

PF13561 (33/33) Enoyl-(Acyl carrier protein) reductase
PF13378 (33/33) Enolase C-terminal domain-like
PF07729 (33/33) FCD domain
PF02746 (33/33) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01081 (33/33) KDPG and KHG aldolase
PF00392 (33/33) Bacterial regulatory proteins, gntR family
PF16875 (31/33) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (31/33) Glycosyl hydrolase family 36 C-terminal domain
PF02065 (31/33) Melibiase
PF01547 (31/33) Bacterial extracellular solute-binding protein
PF00528 (31/33) Binding-protein-dependent transport system inner membrane component
PF00294 (31/33) pfkB family carbohydrate kinase
PF08450 (27/33) SMP-30/Gluconolactonase/LRE-like region
PF17801 (25/33) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (25/33) Alpha galactosidase A
jaccard_groups_4707 138.40 +- 88.49 3 0 1 0 0.02 +- 0.02 3 6

PF14525 (3/3) AraC-binding-like domain
PF12833 (3/3) Helix-turn-helix domain
PF01551 (3/3) Peptidase family M23
PF01471 (3/3) Putative peptidoglycan binding domain
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF01510 (2/3) N-acetylmuramoyl-L-alanine amidase
jaccard_groups_4705 1286.30 +- 861.85 3 0 1 0 0.02 +- 0.03 3 5

PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00459 (3/3) Inositol monophosphatase family
PF00251 (2/3) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_1623 11.05 +- 2.91 8 0 3 0 0.20 +- 0.14 8 4

PF01070 (8/8) FMN-dependent dehydrogenase
PF02133 (7/8) Permease for cytosine/purines, uracil, thiamine, allantoin
PF12697 (6/8) Alpha/beta hydrolase family
PF02826 (6/8) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_4708 27.82 +- 4.88 2 0 0 0 0.11 +- 0.09 2 10

PF17874 (2/2) MalT-like TPR region
PF07719 (2/2) Tetratricopeptide repeat
PF00857 (2/2) Isochorismatase family
PF00348 (2/2) Polyprenyl synthetase
TIGR03025 (1/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13761 (1/2) Domain of unknown function (DUF4166)
PF13692 (1/2) Glycosyl transferases group 1
PF13439 (1/2) Glycosyltransferase Family 4
PF02397 (1/2) Bacterial sugar transferase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_4709 1148.36 +- 915.64 2 0 2 0 0.04 +- 0.17 2 21

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_3848 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
jaccard_groups_2003 294.72 +- 96.02 7 0 6 0 0.03 +- 0.09 7 12

PF13535 (7/7) ATP-grasp domain
PF13344 (7/7) Haloacid dehalogenase-like hydrolase
PF13242 (7/7) HAD-hyrolase-like
PF07690 (7/7) Major Facilitator Superfamily
PF03364 (7/7) Polyketide cyclase / dehydrase and lipid transport
PF01663 (7/7) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01326 (7/7) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00999 (7/7) Sodium/hydrogen exchanger family
PF00391 (7/7) PEP-utilising enzyme, mobile domain
PF00149 (7/7) Calcineurin-like phosphoesterase
TIGR01458 (6/7) HAD hydrolase, TIGR01458 family
PF18603 (6/7) L-amino acid ligase C-terminal domain 2
jaccard_groups_1620 70.24 +- 15.16 2 0 0 0 0.19 +- 0.21 2 14

TIGR04022 (2/2) sulfur acquisition oxidoreductase, SfnB family
TIGR03567 (2/2) FMN reductase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00296 (2/2) Luciferase-like monooxygenase
TIGR04021 (1/2) dimethyl sulfone monooxygenase SfnG
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00664 (1/2) ABC transporter transmembrane region
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
jaccard_groups_567 374.84 +- 408.21 36 0 3 0 0.03 +- 0.05 36 4

PF17390 (36/36) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (36/36) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (35/36) Alpha-L-rhamnosidase N-terminal domain
PF05592 (34/36) Bacterial alpha-L-rhamnosidase concanavalin-like domain
jaccard_groups_561 101.87 +- 83.26 6 0 2 0 0.06 +- 0.13 6 3

TIGR02276 (6/6) 40-residue YVTN family beta-propeller repeat
PF10282 (5/6) Lactonase, 7-bladed beta-propeller
PF01833 (4/6) IPT/TIG domain
jaccard_groups_560 253.64 +- 136.36 2 0 0 0 0.01 +- 0.01 2 6

TIGR02772 (2/2) Ku protein
PF02735 (2/2) Ku70/Ku80 beta-barrel domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF07690 (1/2) Major Facilitator Superfamily
PF03621 (1/2) MbtH-like protein
PF00501 (1/2) AMP-binding enzyme
jaccard_groups_4966 182.55 +- 49.54 3 0 3 0 0.07 +- 0.09 3 10

PF16864 (3/3) Dimerisation domain
PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF04672 (3/3) S-adenosyl methyltransferase
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00891 (3/3) O-methyltransferase domain
PF00664 (3/3) ABC transporter transmembrane region
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
jaccard_groups_4964 466.64 +- 29.79 3 0 3 3 0.02 +- 0.02 3 13

TIGR00928 (3/3) adenylosuccinate lyase
PF13673 (3/3) Acetyltransferase (GNAT) domain
PF10397 (3/3) Adenylosuccinate lyase C-terminus
PF07690 (3/3) Major Facilitator Superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (3/3) Bacterial transcriptional activator domain
PF01425 (3/3) Amidase
PF00931 (3/3) NB-ARC domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00206 (3/3) Lyase
PF00120 (3/3) Glutamine synthetase, catalytic domain
PF13454 (2/3) FAD-NAD(P)-binding
PF07969 (2/3) Amidohydrolase family
jaccard_groups_3286 39.76 +- 9.76 2 0 1 0 0.05 +- 0.03 2 4

PF11806 (2/2) Domain of unknown function (DUF3327)
PF00756 (2/2) Putative esterase
PF12802 (1/2) MarR family
PF06722 (1/2) Protein of unknown function (DUF1205)
jaccard_groups_986 88.45 +- 26.60 18 0 0 0 0.17 +- 0.21 18 14

TIGR00193 (18/18) urease, gamma subunit
PF13977 (18/18) BetI-type transcriptional repressor, C-terminal
PF01979 (18/18) Amidohydrolase family
PF00699 (18/18) Urease beta subunit
PF00547 (18/18) Urease, gamma subunit
PF00449 (18/18) Urease alpha-subunit, N-terminal domain
PF00440 (18/18) Bacterial regulatory proteins, tetR family
PF00005 (18/18) ABC transporter
PF04371 (16/18) Porphyromonas-type peptidyl-arginine deiminase
PF00528 (16/18) Binding-protein-dependent transport system inner membrane component
PF00496 (16/18) Bacterial extracellular solute-binding proteins, family 5 Middle
TIGR01727 (13/18) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (13/18) Oligopeptide/dipeptide transporter, C-terminal region
PF12770 (9/18) CHAT domain
jaccard_groups_3283 25.94 +- 5.77 2 0 0 0 0.11 +- 0.24 2 7

PF05901 (2/2) Excalibur calcium-binding domain
TIGR02532 (1/2) prepilin-type N-terminal cleavage/methylation domain
PF07963 (1/2) Prokaryotic N-terminal methylation motif
PF07884 (1/2) Vitamin K epoxide reductase family
PF03795 (1/2) YCII-related domain
PF00254 (1/2) FKBP-type peptidyl-prolyl cis-trans isomerase
PF00067 (1/2) Cytochrome P450
jaccard_groups_4567 112.24 +- 3.04 2 0 0 0 0.03 +- 0.03 2 6

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07519 (2/2) Tannase and feruloyl esterase
PF05685 (2/2) Putative restriction endonuclease
PF00589 (2/2) Phage integrase family
PF00501 (2/2) AMP-binding enzyme
jaccard_groups_4564 463.39 +- 316.61 2 0 0 0 0.02 +- 0.03 2 11

TIGR03989 (2/2) NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00067 (2/2) Cytochrome P450
PF17754 (1/2) MftR C-terminal domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF01636 (1/2) Phosphotransferase enzyme family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_4565 119.95 +- 101.19 2 0 0 0 0.14 +- 0.26 2 10

PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR00223 (1/2) aspartate 1-decarboxylase
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF12867 (1/2) DinB superfamily
PF02261 (1/2) Aspartate decarboxylase
PF01206 (1/2) Sulfurtransferase TusA
jaccard_groups_4562 10.10 +- 0.89 2 0 1 0 0.20 +- 0.37 2 7

PF14016 (2/2) Protein of unknown function (DUF4232)
PF13424 (2/2) Tetratricopeptide repeat
PF05685 (2/2) Putative restriction endonuclease
PF03704 (2/2) Bacterial transcriptional activator domain
PF02127 (2/2) Aminopeptidase I zinc metalloprotease (M18)
PF13191 (1/2) AAA ATPase domain
PF00931 (1/2) NB-ARC domain
jaccard_groups_4563 487.95 +- 410.12 3 0 0 0 0.03 +- 0.04 3 5

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00248 (2/3) Aldo/keto reductase family
PF00144 (2/3) Beta-lactamase
PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_4568 130.59 +- 94.66 3 0 3 3 0.10 +- 0.26 3 9

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF05173 (3/3) Dihydrodipicolinate reductase, C-terminus
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00881 (3/3) Nitroreductase family
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF01113 (2/3) Dihydrodipicolinate reductase, N-terminus
jaccard_groups_366 22.00 +- 11.79 25 0 7 0 0.17 +- 0.14 25 4

PF00384 (25/25) Molybdopterin oxidoreductase
PF01568 (23/25) Molydopterin dinucleotide binding domain
PF13247 (15/25) 4Fe-4S dicluster domain
PF04879 (15/25) Molybdopterin oxidoreductase Fe4S4 domain
jaccard_groups_368 30.91 +- 8.89 3 0 0 0 0.13 +- 0.08 3 3

TIGR00630 (3/3) excinuclease ABC subunit A
PF17755 (3/3) UvrA DNA-binding domain
PF00005 (3/3) ABC transporter
jaccard_groups_6529 403.02 +- 48.48 2 0 0 1 0.03 +- 0.06 2 11

PF13577 (2/2) SnoaL-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00743 (2/2) Flavin-binding monooxygenase-like
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
jaccard_groups_6524 166.53 +- 14.34 2 0 2 0 0.07 +- 0.15 2 10

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF03861 (2/2) ANTAR domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00571 (2/2) CBS domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_6526 46.94 +- 3.06 2 0 0 0 0.11 +- 0.26 2 8

TIGR03445 (2/2) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01817 (2/2) Chorismate mutase type II
PF01425 (2/2) Amidase
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_3061 210.70 +- 4.30 2 0 1 0 0.02 +- 0.01 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF07366 (1/2) SnoaL-like polyketide cyclase
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_3066 50.39 +- 31.44 6 0 0 0 0.05 +- 0.04 6 2

PF06751 (6/6) Ethanolamine ammonia lyase large subunit (EutB)
PF05985 (6/6) Ethanolamine ammonia-lyase light chain (EutC)
jaccard_groups_3064 150.20 +- 211.20 4 0 0 3 0.13 +- 0.26 4 13

TIGR00724 (4/4) biotin-dependent carboxylase uncharacterized domain
PF07729 (4/4) FCD domain
PF07690 (4/4) Major Facilitator Superfamily
PF07286 (4/4) Protein of unknown function (DUF1445)
PF03746 (4/4) LamB/YcsF family
PF02682 (4/4) Carboxyltransferase domain, subdomain C and D
PF02626 (4/4) Carboxyltransferase domain, subdomain A and B
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (4/4) Bacterial regulatory proteins, gntR family
TIGR04187 (3/4) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (3/4) putative ATP-grasp target RiPP
PF14404 (3/4) Ribosomally synthesized peptide in Streptomyces species
PF08242 (3/4) Methyltransferase domain
jaccard_groups_3444 191.28 +- 79.56 6 0 6 6 0.07 +- 0.08 6 9

PF08386 (6/6) TAP-like protein
PF05532 (6/6) CsbD-like
PF05147 (6/6) Lanthionine synthetase C-like protein
PF00664 (6/6) ABC transporter transmembrane region
PF00561 (6/6) alpha/beta hydrolase fold
PF00069 (6/6) Protein kinase domain
PF00005 (6/6) ABC transporter
PF12697 (5/6) Alpha/beta hydrolase family
PF00117 (4/6) Glutamine amidotransferase class-I
jaccard_groups_6146 334.54 +- 310.46 2 0 0 0 0.11 +- 0.22 2 8

PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_6145 27.87 +- 5.97 2 0 0 0 0.15 +- 0.11 2 7

TIGR02286 (2/2) phenylacetic acid degradation protein PaaD
PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF17754 (1/2) MftR C-terminal domain
jaccard_groups_3449 27.10 +- 9.02 3 0 3 0 0.19 +- 0.30 3 8

PF13410 (3/3) Glutathione S-transferase, C-terminal domain
PF13409 (3/3) Glutathione S-transferase, N-terminal domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF03422 (3/3) Carbohydrate binding module (family 6)
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00722 (3/3) Glycosyl hydrolases family 16
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF13230 (2/3) Glutamine amidotransferases class-II
jaccard_groups_6140 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
jaccard_groups_2867 29.70 +- 3.24 10 0 10 0 0.15 +- 0.15 10 7

PF13620 (10/10) Carboxypeptidase regulatory-like domain
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF11512 (10/10) Agrobacterium tumefaciens protein Atu4866
PF04264 (10/10) YceI-like domain
PF00005 (10/10) ABC transporter
PF04978 (9/10) Protein of unknown function (DUF664)
PF02585 (5/10) GlcNAc-PI de-N-acetylase
jaccard_groups_777 37.18 +- 18.34 7 0 1 0 0.11 +- 0.14 7 4

PF13203 (7/7) Putative metallopeptidase domain
PF09967 (7/7) VWA-like domain (DUF2201)
PF07728 (7/7) AAA domain (dynein-related subfamily)
PF13516 (5/7) Leucine Rich repeat
jaccard_groups_774 89.86 +- 62.83 3 0 0 0 0.06 +- 0.06 3 3

PF01297 (3/3) Zinc-uptake complex component A periplasmic
PF00950 (3/3) ABC 3 transport family
PF00005 (3/3) ABC transporter
jaccard_groups_772 455.00 +- 195.00 2 0 0 0 0.01 +- 0.00 2 3

PF00246 (2/2) Zinc carboxypeptidase
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF00082 (1/2) Subtilase family
jaccard_groups_770 173.39 +- 75.56 3 0 0 0 0.02 +- 0.02 3 4

PF07555 (3/3) beta-N-acetylglucosaminidase
PF02838 (3/3) Glycosyl hydrolase family 20, domain 2
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF09084 (2/3) NMT1/THI5 like
jaccard_groups_3664 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
jaccard_groups_3665 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
jaccard_groups_3666 17.52 +- 1.02 3 0 0 0 0.23 +- 0.33 3 11

PF14509 (3/3) Glycosyl-hydrolase 97 C-terminal, oligomerisation
PF14508 (3/3) Glycosyl-hydrolase 97 N-terminal
PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF10566 (3/3) Glycoside hydrolase 97
PF08305 (3/3) NPCBM/NEW2 domain
PF07730 (3/3) Histidine kinase
PF03176 (3/3) MMPL family
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00069 (3/3) Protein kinase domain
jaccard_groups_3660 156.60 +- 58.07 6 0 0 0 0.08 +- 0.13 6 7

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF07045 (6/6) Domain of unknown function (DUF1330)
PF01738 (6/6) Dienelactone hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00005 (6/6) ABC transporter
jaccard_groups_5550 131.16 +- 62.34 2 0 0 0 0.03 +- 0.03 2 4

PF18370 (2/2) Rhamnogalacturonan I lyases beta-sheet domain
PF10503 (2/2) Esterase PHB depolymerase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450
jaccard_groups_6453 116.12 +- 4.23 2 0 1 0 0.15 +- 0.28 2 26

TIGR03221 (2/2) muconolactone delta-isomerase
TIGR02438 (2/2) catechol 1,2-dioxygenase
PF13577 (2/2) SnoaL-like domain
PF13532 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13378 (2/2) Enolase C-terminal domain-like
PF12891 (2/2) Glycoside hydrolase family 44
PF09339 (2/2) IclR helix-turn-helix domain
PF07745 (2/2) Glycosyl hydrolase family 53
PF07690 (2/2) Major Facilitator Superfamily
PF04444 (2/2) Catechol dioxygenase N terminus
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02426 (2/2) Muconolactone delta-isomerase
PF01614 (2/2) Bacterial transcriptional regulator
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00866 (2/2) Ring hydroxylating beta subunit
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00775 (2/2) Dioxygenase
PF00553 (2/2) Cellulose binding domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (2/2) short chain dehydrogenase
PF00041 (2/2) Fibronectin type III domain
jaccard_groups_2712 63.54 +- 47.76 10 0 3 0 0.10 +- 0.07 10 10

TIGR00745 (10/10) 2-dehydropantoate 2-reductase
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF08546 (10/10) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (10/10) Ketopantoate reductase PanE/ApbA
PF01546 (10/10) Peptidase family M20/M25/M40
PF01522 (10/10) Polysaccharide deacetylase
PF07690 (9/10) Major Facilitator Superfamily
PF13404 (8/10) AsnC-type helix-turn-helix domain
PF01037 (8/10) Lrp/AsnC ligand binding domain
PF13412 (6/10) Winged helix-turn-helix DNA-binding
jaccard_groups_2710 199.15 +- 52.66 7 0 7 0 0.02 +- 0.01 7 8

PF11639 (7/7) REDY-like protein HapK
PF03704 (7/7) Bacterial transcriptional activator domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF02771 (7/7) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (7/7) Acyl-CoA dehydrogenase, middle domain
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00441 (7/7) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_2715 101.04 +- 7.62 2 0 0 0 0.06 +- 0.06 2 13

TIGR03182 (2/2) pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04972 (2/2) BON domain
PF02817 (2/2) e3 binding domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00571 (2/2) CBS domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF00582 (1/2) Universal stress protein family
jaccard_groups_6036 301.83 +- 85.17 2 0 0 2 0.01 +- 0.00 2 7

PF13620 (2/2) Carboxypeptidase regulatory-like domain
PF09861 (2/2) Lactate racemase N-terminal domain
PF04264 (2/2) YceI-like domain
PF00733 (2/2) Asparagine synthase
PF00731 (2/2) AIR carboxylase
PF00083 (2/2) Sugar (and other) transporter
TIGR00268 (1/2) TIGR00268 family protein
jaccard_groups_2009 91.38 +- 147.38 18 0 18 0 0.07 +- 0.11 18 3

PF00550 (18/18) Phosphopantetheine attachment site
PF00067 (17/18) Cytochrome P450
PF00268 (15/18) Ribonucleotide reductase, small chain
jaccard_groups_2008 93.11 +- 28.77 3 0 0 0 0.07 +- 0.12 3 5

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00248 (2/3) Aldo/keto reductase family
jaccard_groups_2825 430.27 +- 474.47 10 0 10 0 0.12 +- 0.27 10 24

TIGR01830 (10/10) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (10/10) amino acid adenylation domain
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF12697 (10/10) Alpha/beta hydrolase family
PF07977 (10/10) FabA-like domain
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF01323 (10/10) DSBA-like thioredoxin domain
PF00975 (10/10) Thioesterase domain
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
TIGR01188 (9/10) daunorubicin resistance ABC transporter, ATP-binding protein
PF01061 (9/10) ABC-2 type transporter
PF00005 (9/10) ABC transporter
TIGR01720 (8/10) non-ribosomal peptide synthase domain TIGR01720
PF01593 (8/10) Flavin containing amine oxidoreductase
PF00067 (8/10) Cytochrome P450
PF13732 (7/10) Domain of unknown function (DUF4162)
TIGR01426 (5/10) glycosyltransferase, MGT family
PF03109 (5/10) ABC1 family
PF02635 (5/10) DsrE/DsrF-like family
PF00201 (5/10) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_5848 106.21 +- 33.08 2 0 1 0 0.04 +- 0.04 2 5

PF04909 (2/2) Amidohydrolase
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00221 (2/2) Aromatic amino acid lyase
PF05995 (1/2) Cysteine dioxygenase type I
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
jaccard_groups_5849 1419.00 +- 258.00 2 0 2 0 0.01 +- 0.00 2 21

TIGR03297 (2/2) phosphonopyruvate decarboxylase
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01909 (2/2) Nucleotidyltransferase domain
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00334 (2/2) Nucleoside diphosphate kinase
PF00155 (2/2) Aminotransferase class I and II
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF14907 (1/2) Uncharacterised nucleotidyltransferase
PF14023 (1/2) Protein of unknown function (DUF4239)
PF13535 (1/2) ATP-grasp domain
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF02310 (1/2) B12 binding domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00487 (1/2) Fatty acid desaturase
jaccard_groups_5885 178.96 +- 22.96 2 0 0 0 0.10 +- 0.22 2 25

TIGR01792 (2/2) urease, alpha subunit
TIGR00836 (2/2) ammonium transporter
TIGR00193 (2/2) urease, gamma subunit
TIGR00192 (2/2) urease, beta subunit
TIGR00101 (2/2) urease accessory protein UreG
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF04041 (2/2) beta-1,4-mannooligosaccharide phosphorylase
PF03253 (2/2) Urea transporter
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01979 (2/2) Amidohydrolase family
PF01774 (2/2) UreD urease accessory protein
PF01730 (2/2) UreF
PF00909 (2/2) Ammonium Transporter Family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
jaccard_groups_5843 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF07538 (2/2) Clostridial hydrophobic W
PF07179 (2/2) SseB protein N-terminal domain
PF04198 (2/2) Putative sugar-binding domain
PF03692 (2/2) Putative zinc- or iron-chelating domain
jaccard_groups_5840 19.85 +- 1.88 2 0 0 0 0.20 +- 0.30 2 10

TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF13580 (2/2) SIS domain
PF07075 (2/2) Protein of unknown function (DUF1343)
PF05547 (2/2) Immune inhibitor A peptidase M6
PF03824 (2/2) High-affinity nickel-transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00144 (2/2) Beta-lactamase
jaccard_groups_2398 239.67 +- 174.94 3 0 0 0 0.03 +- 0.02 3 5

TIGR00979 (3/3) fumarate hydratase, class II
PF10415 (3/3) Fumarase C C-terminus
PF03949 (3/3) Malic enzyme, NAD binding domain
PF00390 (3/3) Malic enzyme, N-terminal domain
PF00206 (3/3) Lyase
jaccard_groups_6371 835.89 +- 724.11 2 0 0 0 0.09 +- 0.21 2 19

TIGR01186 (2/2) glycine betaine/L-proline transport ATP binding subunit
PF13183 (2/2) 4Fe-4S dicluster domain
PF09339 (2/2) IclR helix-turn-helix domain
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF01614 (2/2) Bacterial transcriptional regulator
PF01565 (2/2) FAD binding domain
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF13520 (1/2) Amino acid permease
PF12146 (1/2) Serine aminopeptidase, S33
PF05331 (1/2) Protein of unknown function (DUF742)
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00171 (1/2) Aldehyde dehydrogenase family
PF00067 (1/2) Cytochrome P450
jaccard_groups_2629 202.96 +- 412.11 8 0 6 0 0.09 +- 0.16 8 5

PF07690 (8/8) Major Facilitator Superfamily
TIGR00711 (7/8) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07883 (7/8) Cupin domain
PF12697 (6/8) Alpha/beta hydrolase family
PF00069 (5/8) Protein kinase domain
jaccard_groups_5425 800.15 +- 419.49 2 0 0 0 0.03 +- 0.02 2 15

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17645 (2/2) Arylmalonate decarboxylase
PF09339 (2/2) IclR helix-turn-helix domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02426 (2/2) Muconolactone delta-isomerase
PF01614 (2/2) Bacterial transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13489 (1/2) Methyltransferase domain
PF05685 (1/2) Putative restriction endonuclease
PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2625 186.70 +- 56.43 4 0 0 0 0.01 +- 0.01 4 6

PF17963 (4/4) Bacterial Ig domain
PF13472 (4/4) GDSL-like Lipase/Acylhydrolase family
PF09992 (4/4) Phosphodiester glycosidase
PF04464 (4/4) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF01066 (4/4) CDP-alcohol phosphatidyltransferase
PF00535 (4/4) Glycosyl transferase family 2
jaccard_groups_2852 524.78 +- 612.66 9 0 9 0 0.05 +- 0.16 9 11

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
TIGR00652 (9/9) diaminopimelate epimerase
PF18130 (9/9) ATP-grasp N-terminal domain
PF14518 (9/9) Iron-containing redox enzyme
PF13535 (9/9) ATP-grasp domain
PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF10014 (9/9) 2OG-Fe dioxygenase
PF07690 (9/9) Major Facilitator Superfamily
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01678 (9/9) Diaminopimelate epimerase
PF00155 (9/9) Aminotransferase class I and II
jaccard_groups_2136 1062.06 +- 243.37 18 2 8 18 0.01 +- 0.01 16 6

PF13186 (18/18) Iron-sulfur cluster-binding domain
PF04055 (18/18) Radical SAM superfamily
PF00005 (18/18) ABC transporter
TIGR04085 (17/18) radical SAM additional 4Fe4S-binding SPASM domain
PF05402 (17/18) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (16/18) ABC-2 type transporter
jaccard_groups_2323 63.73 +- 45.45 12 0 1 0 0.06 +- 0.12 12 5

PF03965 (12/12) Penicillinase repressor
PF01435 (12/12) Peptidase family M48
PF00403 (12/12) Heavy-metal-associated domain
PF12229 (10/12) Putative peptidoglycan binding domain
PF04294 (10/12) VanW like protein
jaccard_groups_5441 486.41 +- 428.32 2 0 0 0 0.08 +- 0.22 2 16

TIGR01766 (2/2) transposase, IS605 OrfB family
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12730 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF02698 (2/2) DUF218 domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF05630 (1/2) Necrosis inducing protein (NPP1)
PF02057 (1/2) Glycosyl hydrolase family 59
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
jaccard_groups_5447 680.25 +- 99.75 2 0 2 0 0.01 +- 0.00 2 8

PF08031 (2/2) Berberine and berberine like
PF06236 (2/2) Tyrosinase co-factor MelC1
PF03704 (2/2) Bacterial transcriptional activator domain
PF01565 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00264 (2/2) Common central domain of tyrosinase
PF00221 (2/2) Aromatic amino acid lyase
jaccard_groups_5444 23.69 +- 4.82 2 0 0 0 0.21 +- 0.35 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00178 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF03971 (2/2) Monomeric isocitrate dehydrogenase
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00248 (2/2) Aldo/keto reductase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF07690 (1/2) Major Facilitator Superfamily
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_4445 36.86 +- 2.91 4 0 0 0 0.11 +- 0.18 4 5

PF11239 (4/4) Protein of unknown function (DUF3040)
PF07690 (4/4) Major Facilitator Superfamily
PF04203 (4/4) Sortase domain
PF02610 (4/4) L-arabinose isomerase
PF00999 (4/4) Sodium/hydrogen exchanger family
jaccard_groups_6376 1036.00 +- 4.00 2 0 0 0 0.01 +- 0.00 2 6

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_5932 497.50 +- 282.50 2 0 2 0 0.02 +- 0.03 2 13

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00535 (2/2) Glycosyl transferase family 2
PF00202 (2/2) Aminotransferase class-III
PF00107 (2/2) Zinc-binding dehydrogenase
PF13377 (1/2) Periplasmic binding protein-like domain
PF07081 (1/2) Protein of unknown function (DUF1349)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00550 (1/2) Phosphopantetheine attachment site
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_608 62.75 +- 65.87 11 0 5 0 0.10 +- 0.15 11 4

PF01794 (11/11) Ferric reductase like transmembrane component
PF00175 (11/11) Oxidoreductase NAD-binding domain
PF04205 (9/11) FMN-binding domain
PF02424 (9/11) ApbE family
jaccard_groups_5814 2680.76 +- 157.24 2 0 2 0 0.01 +- 0.00 2 16

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10067 (2/2) Predicted membrane protein (DUF2306)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01757 (2/2) Acyltransferase family
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00144 (2/2) Beta-lactamase
jaccard_groups_603 134.38 +- 89.17 3 0 1 0 0.02 +- 0.03 3 2

PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF02156 (2/3) Glycosyl hydrolase family 26
jaccard_groups_601 158.82 +- 179.45 86 0 49 84 0.07 +- 0.19 86 4

PF07690 (86/86) Major Facilitator Superfamily
PF04055 (84/86) Radical SAM superfamily
PF00326 (79/86) Prolyl oligopeptidase family
PF02897 (52/86) Prolyl oligopeptidase, N-terminal beta-propeller domain
jaccard_groups_606 75.88 +- 82.42 10 0 0 1 0.07 +- 0.09 10 4

PF05270 (10/10) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (9/10) Glycosyl hydrolases family 43
PF14200 (7/10) Ricin-type beta-trefoil lectin domain-like
PF09997 (5/10) Predicted membrane protein (DUF2238)
jaccard_groups_607 13.38 +- 4.37 3 0 0 0 0.23 +- 0.38 3 3

TIGR02891 (3/3) cytochrome c oxidase, subunit I
PF00115 (3/3) Cytochrome C and Quinol oxidase polypeptide I
PF12270 (2/3) Cytochrome c oxidase subunit IV
jaccard_groups_604 376.36 +- 565.42 37 0 8 0 0.08 +- 0.10 37 3

PF09084 (37/37) NMT1/THI5 like
PF00005 (37/37) ABC transporter
PF00528 (36/37) Binding-protein-dependent transport system inner membrane component
jaccard_groups_605 69.51 +- 65.20 16 0 1 0 0.11 +- 0.17 16 5

PF00581 (16/16) Rhodanese-like domain
PF11127 (15/16) Protein of unknown function (DUF2892)
PF01925 (14/16) Sulfite exporter TauE/SafE
PF00753 (14/16) Metallo-beta-lactamase superfamily
PF02583 (10/16) Metal-sensitive transcriptional repressor
jaccard_groups_2530 108.97 +- 49.36 7 0 2 0 0.04 +- 0.03 7 5

PF07702 (7/7) UTRA domain
PF03747 (7/7) ADP-ribosylglycohydrolase
PF00392 (7/7) Bacterial regulatory proteins, gntR family
PF00294 (7/7) pfkB family carbohydrate kinase
PF02133 (6/7) Permease for cytosine/purines, uracil, thiamine, allantoin
jaccard_groups_5719 39.07 +- 5.52 2 0 0 0 0.11 +- 0.16 2 7

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF13560 (2/2) Helix-turn-helix domain
PF13520 (2/2) Amino acid permease
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07883 (2/2) Cupin domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00854 (2/2) POT family
jaccard_groups_5713 396.67 +- 119.33 2 0 2 0 0.01 +- 0.00 2 8

TIGR00052 (2/2) nudix-type nucleoside diphosphatase, YffH/AdpP family
PF13855 (2/2) Leucine rich repeat
PF13516 (2/2) Leucine Rich repeat
PF07690 (2/2) Major Facilitator Superfamily
PF02641 (2/2) Uncharacterized ACR, COG1993
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
jaccard_groups_5625 35.34 +- 0.78 2 0 2 0 0.08 +- 0.10 2 4

PF13712 (2/2) Glycosyltransferase like family
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00483 (2/2) Nucleotidyl transferase
jaccard_groups_914 245.78 +- 222.45 39 0 39 0 0.12 +- 0.25 39 16

PF00550 (39/39) Phosphopantetheine attachment site
TIGR01733 (38/39) amino acid adenylation domain
PF00975 (38/39) Thioesterase domain
PF00501 (38/39) AMP-binding enzyme
TIGR01188 (37/39) daunorubicin resistance ABC transporter, ATP-binding protein
PF13193 (37/39) AMP-binding enzyme C-terminal domain
PF03621 (37/39) MbtH-like protein
PF01061 (37/39) ABC-2 type transporter
PF00668 (37/39) Condensation domain
PF00005 (37/39) ABC transporter
TIGR03944 (36/39) 2,3-diaminopropionate biosynthesis protein SbnB
PF02423 (36/39) Ornithine cyclodeaminase/mu-crystallin family
TIGR03945 (35/39) 2,3-diaminopropionate biosynthesis protein SbnA
PF00291 (35/39) Pyridoxal-phosphate dependent enzyme
TIGR01720 (33/39) non-ribosomal peptide synthase domain TIGR01720
PF13732 (24/39) Domain of unknown function (DUF4162)
jaccard_groups_910 192.70 +- 137.39 3 0 0 0 0.03 +- 0.05 3 3

PF13560 (3/3) Helix-turn-helix domain
PF01471 (3/3) Putative peptidoglycan binding domain
PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family
jaccard_groups_911 100.30 +- 95.35 19 0 6 0 0.07 +- 0.16 19 2

PF08546 (19/19) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (19/19) Ketopantoate reductase PanE/ApbA
jaccard_groups_628 62.67 +- 138.89 136 0 14 0 0.11 +- 0.13 136 5

PF00420 (136/136) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (136/136) Proton-conducting membrane transporter
PF04039 (135/136) Domain related to MnhB subunit of Na+/H+ antiporter
PF13244 (133/136) Domain of unknown function (DUF4040)
PF04066 (133/136) Multiple resistance and pH regulation protein F (MrpF / PhaF)
jaccard_groups_5154 1905.20 +- 308.06 3 0 3 3 0.02 +- 0.02 3 11

PF16864 (3/3) Dimerisation domain
PF13471 (3/3) Transglutaminase-like superfamily
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01494 (3/3) FAD binding domain
PF00891 (3/3) O-methyltransferase domain
PF00733 (3/3) Asparagine synthase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
jaccard_groups_5156 556.00 +- 402.80 3 0 0 0 0.03 +- 0.06 3 12

TIGR01409 (3/3) Tat (twin-arginine translocation) pathway signal sequence
PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (3/3) Major Facilitator Superfamily
PF04616 (3/3) Glycosyl hydrolases family 43
PF02449 (3/3) Beta-galactosidase
PF00801 (3/3) PKD domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00005 (3/3) ABC transporter
jaccard_groups_5150 691.01 +- 84.49 3 0 3 0 0.07 +- 0.18 3 17

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/3) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/3) Beta-lactamase superfamily domain
PF12697 (3/3) Alpha/beta hydrolase family
PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/3) ParB-like nuclease domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
jaccard_groups_822 411.67 +- 238.33 2 0 0 0 0.01 +- 0.01 2 6

PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
PF07690 (1/2) Major Facilitator Superfamily
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
jaccard_groups_823 124.90 +- 109.55 5 0 0 0 0.06 +- 0.10 5 3

PF01656 (5/5) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01234 (5/5) NNMT/PNMT/TEMT family
PF06609 (3/5) Fungal trichothecene efflux pump (TRI12)
jaccard_groups_826 119.70 +- 69.55 8 0 1 0 0.03 +- 0.03 8 5

TIGR01840 (8/8) esterase, PHB depolymerase family
PF10503 (8/8) Esterase PHB depolymerase
TIGR00666 (5/8) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (5/8) Protein of unknown function (DUF4232)
PF02113 (5/8) D-Ala-D-Ala carboxypeptidase 3 (S13) family
jaccard_groups_824 96.39 +- 33.04 7 0 7 0 0.04 +- 0.05 7 3

PF00494 (7/7) Squalene/phytoene synthase
PF00348 (7/7) Polyprenyl synthetase
PF00005 (7/7) ABC transporter
jaccard_groups_134 21.71 +- 3.78 2 0 0 0 0.12 +- 0.08 2 7

PF13520 (2/2) Amino acid permease
PF13546 (1/2) DDE superfamily endonuclease
PF07969 (1/2) Amidohydrolase family
PF04978 (1/2) Protein of unknown function (DUF664)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00704 (1/2) Glycosyl hydrolases family 18
PF00067 (1/2) Cytochrome P450
jaccard_groups_1726 38.86 +- 24.45 10 0 3 0 0.15 +- 0.17 10 8

PF08240 (10/10) Alcohol dehydrogenase GroES-like domain
PF00107 (10/10) Zinc-binding dehydrogenase
PF08445 (9/10) FR47-like protein
PF07228 (9/10) Stage II sporulation protein E (SpoIIE)
PF00440 (9/10) Bacterial regulatory proteins, tetR family
PF17754 (8/10) MftR C-terminal domain
PF00005 (8/10) ABC transporter
PF13561 (7/10) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_1725 10.33 +- 1.22 2 0 1 0 0.19 +- 0.28 2 3

PF03099 (2/2) Biotin/lipoate A/B protein ligase family
PF01979 (1/2) Amidohydrolase family
PF01494 (1/2) FAD binding domain
jaccard_groups_1721 107.85 +- 88.00 14 0 2 0 0.04 +- 0.05 14 3

PF00583 (13/14) Acetyltransferase (GNAT) family
PF00106 (12/14) short chain dehydrogenase
PF01068 (8/14) ATP dependent DNA ligase domain
jaccard_groups_137 113.61 +- 136.86 8 0 0 0 0.10 +- 0.14 8 3

TIGR01930 (8/8) acetyl-CoA C-acyltransferase
PF02803 (8/8) Thiolase, C-terminal domain
PF00108 (8/8) Thiolase, N-terminal domain
jaccard_groups_178 222.10 +- 140.74 7 0 5 0 0.02 +- 0.02 7 1

PF01471 (7/7) Putative peptidoglycan binding domain
jaccard_groups_177 135.90 +- 123.02 11 0 7 0 0.05 +- 0.07 11 2

PF01510 (11/11) N-acetylmuramoyl-L-alanine amidase
PF01183 (6/11) Glycosyl hydrolases family 25
jaccard_groups_171 137.41 +- 249.67 51 0 5 0 0.11 +- 0.22 51 3

PF02868 (51/51) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (51/51) Thermolysin metallopeptidase, catalytic domain
PF07504 (44/51) Fungalysin/Thermolysin Propeptide Motif
jaccard_groups_172 101.05 +- 103.20 43 0 11 0 0.05 +- 0.13 43 2

PF11716 (43/43) Mycothiol maleylpyruvate isomerase N-terminal domain
TIGR03083 (41/43) uncharacterized Actinobacterial protein TIGR03083
jaccard_groups_173 419.49 +- 518.55 227 0 223 7 0.07 +- 0.17 227 11

PF00550 (227/227) Phosphopantetheine attachment site
PF00501 (226/227) AMP-binding enzyme
PF02801 (225/227) Beta-ketoacyl synthase, C-terminal domain
PF00109 (225/227) Beta-ketoacyl synthase, N-terminal domain
PF13193 (219/227) AMP-binding enzyme C-terminal domain
PF16197 (214/227) Ketoacyl-synthetase C-terminal extension
TIGR01733 (201/227) amino acid adenylation domain
PF00698 (196/227) Acyl transferase domain
PF00668 (190/227) Condensation domain
PF00975 (125/227) Thioesterase domain
PF07690 (116/227) Major Facilitator Superfamily
jaccard_groups_1387 34.67 +- 0.00 2 0 2 0 0.06 +- 0.03 2 2

PF03745 (2/2) Domain of unknown function (DUF309)
PF01636 (2/2) Phosphotransferase enzyme family
jaccard_groups_1380 120.19 +- 177.73 32 0 0 0 0.17 +- 0.18 32 14

TIGR01727 (32/32) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (32/32) Oligopeptide/dipeptide transporter, C-terminal region
PF00005 (31/32) ABC transporter
PF13377 (30/32) Periplasmic binding protein-like domain
PF00528 (30/32) Binding-protein-dependent transport system inner membrane component
PF00496 (30/32) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00232 (30/32) Glycosyl hydrolase family 1
TIGR03356 (29/32) beta-galactosidase
PF12911 (29/32) N-terminal TM domain of oligopeptide transport permease C
PF00933 (29/32) Glycosyl hydrolase family 3 N terminal domain
PF00356 (29/32) Bacterial regulatory proteins, lacI family
PF01915 (28/32) Glycosyl hydrolase family 3 C-terminal domain
PF03425 (27/32) Carbohydrate binding domain (family 11)
PF03160 (21/32) Calx-beta domain
jaccard_groups_4175 922.67 +- 269.45 3 0 3 0 0.01 +- 0.00 3 10

TIGR01850 (3/3) N-acetyl-gamma-glutamyl-phosphate reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01118 (3/3) Semialdehyde dehydrogenase, NAD binding domain
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00162 (3/3) Phosphoglycerate kinase
PF13714 (2/3) Phosphoenolpyruvate phosphomutase
PF13535 (2/3) ATP-grasp domain
PF07690 (2/3) Major Facilitator Superfamily
PF02774 (2/3) Semialdehyde dehydrogenase, dimerisation domain
jaccard_groups_4174 307.98 +- 147.17 4 0 0 0 0.02 +- 0.03 4 7

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF01593 (4/4) Flavin containing amine oxidoreductase
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF07690 (3/4) Major Facilitator Superfamily
PF00106 (3/4) short chain dehydrogenase
PF08443 (2/4) RimK-like ATP-grasp domain
jaccard_groups_4177 410.25 +- 124.26 4 0 0 0 0.01 +- 0.01 4 6

PF13599 (4/4) Pentapeptide repeats (9 copies)
PF13489 (4/4) Methyltransferase domain
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF08445 (2/4) FR47-like protein
PF07730 (2/4) Histidine kinase
PF00583 (2/4) Acetyltransferase (GNAT) family
jaccard_groups_4176 426.92 +- 330.10 3 0 3 3 0.01 +- 0.01 3 5

PF08007 (3/3) Cupin superfamily protein
PF07690 (3/3) Major Facilitator Superfamily
PF05114 (3/3) Protein of unknown function (DUF692)
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
jaccard_groups_1389 105.33 +- 49.39 9 0 0 0 0.04 +- 0.04 9 3

PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF01266 (9/9) FAD dependent oxidoreductase
TIGR01428 (8/9) haloacid dehalogenase, type II
jaccard_groups_4173 609.89 +- 483.80 2 0 2 0 0.11 +- 0.30 2 17

TIGR03150 (2/2) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13452 (2/2) N-terminal half of MaoC dehydratase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01061 (2/2) ABC-2 type transporter
PF00856 (2/2) SET domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
jaccard_groups_1434 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF06737 (2/2) Transglycosylase-like domain
PF05257 (2/2) CHAP domain
jaccard_groups_1772 169.45 +- 111.63 20 0 0 0 0.02 +- 0.01 20 5

PF14200 (20/20) Ricin-type beta-trefoil lectin domain-like
PF05270 (20/20) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03752 (20/20) Short repeats of unknown function
PF00652 (20/20) Ricin-type beta-trefoil lectin domain
PF00720 (19/20) Subtilisin inhibitor-like
jaccard_groups_4355 528.78 +- 87.12 4 0 4 0 0.02 +- 0.03 4 6

PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
jaccard_groups_4608 169.00 +- 65.00 2 0 0 0 0.02 +- 0.01 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF04542 (2/2) Sigma-70 region 2
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_4351 75.90 +- 32.99 4 0 0 0 0.15 +- 0.23 4 8

TIGR03444 (4/4) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
PF13620 (4/4) Carboxypeptidase regulatory-like domain
PF13088 (4/4) BNR repeat-like domain
PF11695 (4/4) Domain of unknown function (DUF3291)
PF04264 (4/4) YceI-like domain
PF04248 (4/4) Domain of unknown function (DUF427)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF04978 (3/4) Protein of unknown function (DUF664)
jaccard_groups_4353 222.53 +- 99.37 2 0 1 0 0.05 +- 0.13 2 12

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF05336 (2/2) L-rhamnose mutarotase
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00682 (2/2) HMGL-like
PF00106 (2/2) short chain dehydrogenase
PF02274 (1/2) Amidinotransferase
jaccard_groups_4352 37.31 +- 5.54 3 0 0 0 0.11 +- 0.10 3 5

PF06723 (3/3) MreB/Mbl protein
PF03060 (3/3) Nitronate monooxygenase
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_4359 64.04 +- 23.69 3 0 0 0 0.04 +- 0.02 3 3

PF06912 (3/3) Protein of unknown function (DUF1275)
PF02308 (3/3) MgtC family
PF01566 (3/3) Natural resistance-associated macrophage protein
jaccard_groups_4358 65.25 +- 4.08 2 0 2 0 0.06 +- 0.01 2 3

TIGR04538 (2/2) cytochrome P450, cyclodipeptide synthase-associated
PF00857 (2/2) Isochorismatase family
PF00067 (2/2) Cytochrome P450
jaccard_groups_4604 47.93 +- 14.79 3 0 0 0 0.17 +- 0.29 3 10

TIGR01361 (3/3) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (3/3) DAHP synthase ferredoxin-like domain
PF08031 (3/3) Berberine and berberine like
PF07883 (3/3) Cupin domain
PF01565 (3/3) FAD binding domain
PF01494 (3/3) FAD binding domain
PF00793 (3/3) DAHP synthetase I family
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF07690 (2/3) Major Facilitator Superfamily
jaccard_groups_4776 407.43 +- 112.57 2 0 0 0 0.01 +- 0.00 2 4

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_4775 547.42 +- 584.10 3 0 3 2 0.09 +- 0.23 3 24

TIGR03494 (3/3) salicylate synthase
TIGR02185 (3/3) putative ECF transporter S component, Trep_Strep family
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09605 (3/3) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF03704 (3/3) Bacterial transcriptional activator domain
PF02361 (3/3) Cobalt transport protein
PF00975 (3/3) Thioesterase domain
PF00931 (3/3) NB-ARC domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00425 (3/3) chorismate binding enzyme
PF00005 (3/3) ABC transporter
TIGR03696 (2/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
TIGR01443 (2/3) intein C-terminal splicing region
PF13537 (2/3) Glutamine amidotransferase domain
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat
PF00733 (2/3) Asparagine synthase
PF00664 (2/3) ABC transporter transmembrane region
jaccard_groups_1658 53.08 +- 4.70 2 0 0 0 0.08 +- 0.08 2 4

TIGR02547 (2/2) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
PF13649 (2/2) Methyltransferase domain
PF09481 (2/2) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
jaccard_groups_1653 50.63 +- 9.57 2 0 0 0 0.08 +- 0.05 2 8

TIGR02274 (2/2) deoxycytidine triphosphate deaminase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00144 (2/2) Beta-lactamase
PF13692 (1/2) Glycosyl transferases group 1
PF00534 (1/2) Glycosyl transferases group 1
jaccard_groups_1652 435.72 +- 307.47 24 0 20 0 0.03 +- 0.04 24 6

PF13193 (24/24) AMP-binding enzyme C-terminal domain
PF01959 (24/24) 3-dehydroquinate synthase II
PF01791 (24/24) DeoC/LacD family aldolase
PF01494 (24/24) FAD binding domain
PF00501 (24/24) AMP-binding enzyme
TIGR03892 (18/24) thiazolylpeptide-type bacteriocin precursor
jaccard_groups_4778 424.72 +- 114.31 2 0 2 0 0.02 +- 0.01 2 12

PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07690 (2/2) Major Facilitator Superfamily
PF03060 (2/2) Nitronate monooxygenase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_4285 92.56 +- 69.77 4 0 0 0 0.09 +- 0.09 4 10

TIGR01428 (4/4) haloacid dehalogenase, type II
PF12973 (4/4) ChrR Cupin-like domain
PF01909 (4/4) Nucleotidyltransferase domain
PF00144 (4/4) Beta-lactamase
PF07876 (3/4) Stress responsive A/B Barrel Domain
PF07690 (3/4) Major Facilitator Superfamily
PF13419 (2/4) Haloacid dehalogenase-like hydrolase
PF03466 (2/4) LysR substrate binding domain
PF00702 (2/4) haloacid dehalogenase-like hydrolase
PF00126 (2/4) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_4284 44.95 +- 6.02 4 0 0 0 0.18 +- 0.26 4 10

TIGR03328 (4/4) methylthioribulose-1-phosphate dehydratase
PF01979 (4/4) Amidohydrolase family
PF01048 (4/4) Phosphorylase superfamily
PF00970 (4/4) Oxidoreductase FAD-binding domain
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
TIGR01691 (3/4) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF09754 (3/4) PAC2 family
PF03079 (3/4) ARD/ARD' family
PF00082 (3/4) Subtilase family
jaccard_groups_3877 342.37 +- 307.63 2 0 0 0 0.08 +- 0.25 2 8

PF05544 (2/2) Proline racemase
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07883 (1/2) Cupin domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_3876 19.16 +- 5.85 3 0 0 0 0.13 +- 0.12 3 3

PF04016 (3/3) Putative heavy-metal chelation
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00288 (2/3) GHMP kinases N terminal domain
jaccard_groups_3871 782.71 +- 351.28 4 0 0 0 0.03 +- 0.04 4 11

PF18099 (4/4) DUF5010 C-terminal domain
PF13377 (4/4) Periplasmic binding protein-like domain
PF11941 (4/4) Domain of unknown function (DUF3459)
PF10756 (4/4) Bacterial PH domain
PF03663 (4/4) Glycosyl hydrolase family 76
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00128 (4/4) Alpha amylase, catalytic domain
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (3/4) Dehydratase family
jaccard_groups_4289 84.03 +- 10.11 3 0 0 0 0.04 +- 0.03 3 6

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF17831 (2/3) Pyruvate dehydrogenase E1 component middle domain
PF00456 (2/3) Transketolase, thiamine diphosphate binding domain
PF00296 (2/3) Luciferase-like monooxygenase
PF00293 (2/3) NUDIX domain
jaccard_groups_599 147.51 +- 123.49 3 0 0 0 0.09 +- 0.22 3 4

TIGR00813 (3/3) transporter, solute:sodium symporter (SSS) family
PF00474 (3/3) Sodium:solute symporter family
PF01261 (2/3) Xylose isomerase-like TIM barrel
PF00485 (2/3) Phosphoribulokinase / Uridine kinase family
jaccard_groups_4919 18.15 +- 3.82 3 0 0 0 0.18 +- 0.33 3 7

PF17996 (3/3) Carbohydrate esterase 2 N-terminal
PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01012 (3/3) Electron transfer flavoprotein domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_593 95.79 +- 111.11 23 0 8 0 0.08 +- 0.12 23 5

PF07995 (23/23) Glucose / Sorbosone dehydrogenase
PF06283 (23/23) Trehalose utilisation
PF03422 (23/23) Carbohydrate binding module (family 6)
PF00801 (23/23) PKD domain
PF00652 (13/23) Ricin-type beta-trefoil lectin domain
jaccard_groups_4915 189.58 +- 102.92 2 0 0 0 0.04 +- 0.08 2 7

PF08501 (2/2) Shikimate dehydrogenase substrate binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01487 (2/2) Type I 3-dehydroquinase
PF01451 (2/2) Low molecular weight phosphotyrosine protein phosphatase
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_596 59.35 +- 5.96 3 0 0 0 0.21 +- 0.32 3 9

TIGR03005 (3/3) ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA
TIGR03004 (3/3) ectoine/hydroxyectoine ABC transporter, permease protein EhuC
TIGR03003 (3/3) ectoine/hydroxyectoine ABC transporter, permease protein EhuD
TIGR02995 (3/3) ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00005 (3/3) ABC transporter
PF09339 (2/3) IclR helix-turn-helix domain
PF01614 (2/3) Bacterial transcriptional regulator
jaccard_groups_594 146.05 +- 109.05 8 0 0 0 0.10 +- 0.22 8 2

TIGR03086 (8/8) TIGR03086 family protein
PF11716 (8/8) Mycothiol maleylpyruvate isomerase N-terminal domain
jaccard_groups_3276 214.65 +- 213.40 3 0 3 0 0.03 +- 0.04 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01494 (3/3) FAD binding domain
PF00501 (2/3) AMP-binding enzyme
jaccard_groups_3274 259.00 +- 1.00 2 0 1 0 0.02 +- 0.01 2 8

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF00501 (2/2) AMP-binding enzyme
TIGR01821 (1/2) 5-aminolevulinic acid synthase
PF08241 (1/2) Methyltransferase domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00155 (1/2) Aminotransferase class I and II
jaccard_groups_50 377.68 +- 410.10 3 0 0 0 0.07 +- 0.19 3 2

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
jaccard_groups_51 109.65 +- 52.39 5 0 0 0 0.21 +- 0.33 5 7

TIGR01915 (5/5) NADPH-dependent F420 reductase
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF13560 (4/5) Helix-turn-helix domain
PF13088 (4/5) BNR repeat-like domain
PF01547 (4/5) Bacterial extracellular solute-binding protein
PF01135 (4/5) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/5) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4599 225.46 +- 45.32 3 0 1 0 0.07 +- 0.20 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13621 (3/3) Cupin-like domain
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF09334 (3/3) tRNA synthetases class I (M)
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01266 (3/3) FAD dependent oxidoreductase
PF00501 (3/3) AMP-binding enzyme
PF12704 (2/3) MacB-like periplasmic core domain
PF02687 (2/3) FtsX-like permease family
PF00106 (2/3) short chain dehydrogenase
jaccard_groups_53 44.08 +- 18.71 3 0 0 0 0.09 +- 0.09 3 2

PF13586 (3/3) Transposase DDE domain
PF13340 (2/3) Putative transposase of IS4/5 family (DUF4096)
jaccard_groups_54 116.79 +- 139.57 8 0 0 0 0.10 +- 0.21 8 4

PF01965 (8/8) DJ-1/PfpI family
TIGR01382 (5/8) intracellular protease, PfpI family
PF08240 (5/8) Alcohol dehydrogenase GroES-like domain
PF03928 (5/8) Haem-degrading
jaccard_groups_55 157.99 +- 145.49 72 0 16 0 0.05 +- 0.10 72 2

PF00107 (72/72) Zinc-binding dehydrogenase
PF08240 (70/72) Alcohol dehydrogenase GroES-like domain
jaccard_groups_4592 98.56 +- 21.70 3 0 0 0 0.05 +- 0.05 3 3

PF00561 (3/3) alpha/beta hydrolase fold
PF07883 (2/3) Cupin domain
PF00857 (2/3) Isochorismatase family
jaccard_groups_4596 307.65 +- 79.35 2 0 0 0 0.06 +- 0.06 2 9

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14494 (2/2) Domain of unknown function (DUF4436)
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04371 (2/2) Porphyromonas-type peptidyl-arginine deiminase
PF01590 (2/2) GAF domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
jaccard_groups_355 18.63 +- 8.48 4 0 0 0 0.22 +- 0.32 4 13

TIGR03934 (4/4) TQXA domain
TIGR03719 (4/4) ATP-binding cassette protein, ChvD family
PF12848 (4/4) ABC transporter
PF08341 (4/4) Thioester domain
PF00005 (4/4) ABC transporter
PF03061 (3/4) Thioesterase superfamily
PF01926 (3/4) 50S ribosome-binding GTPase
PF00436 (3/4) Single-strand binding protein family
PF12728 (2/4) Helix-turn-helix domain
PF10935 (2/4) Protein of unknown function (DUF2637)
PF05122 (2/4) Mobile element transfer protein
PF01580 (2/4) FtsK/SpoIIIE family
PF00350 (2/4) Dynamin family
jaccard_groups_357 126.97 +- 92.97 3 0 1 0 0.03 +- 0.04 3 1

PF01553 (3/3) Acyltransferase
jaccard_groups_352 92.01 +- 155.36 98 0 91 0 0.15 +- 0.22 98 11

TIGR03025 (98/98) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (98/98) Glycosyl transferases group 1
PF13439 (98/98) Glycosyltransferase Family 4
PF04932 (98/98) O-Antigen ligase
PF03023 (98/98) Lipid II flippase MurJ
PF02397 (98/98) Bacterial sugar transferase
PF01522 (98/98) Polysaccharide deacetylase
PF13480 (97/98) Acetyltransferase (GNAT) domain
PF00534 (97/98) Glycosyl transferases group 1
PF03777 (89/98) ChpA-C
PF00348 (73/98) Polyprenyl synthetase
jaccard_groups_4821 33.52 +- 4.42 2 0 2 1 0.14 +- 0.30 2 10

TIGR00369 (2/2) uncharacterized domain 1
PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00501 (2/2) AMP-binding enzyme
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00733 (1/2) Asparagine synthase
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_4820 486.75 +- 211.32 3 0 3 0 0.01 +- 0.01 3 4

PF11706 (3/3) CGNR zinc finger
PF01713 (3/3) Smr domain
PF01596 (3/3) O-methyltransferase
PF01494 (3/3) FAD binding domain
jaccard_groups_4825 348.31 +- 195.06 3 0 0 0 0.02 +- 0.03 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12831 (3/3) FAD dependent oxidoreductase
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF02515 (3/3) CoA-transferase family III
PF01381 (3/3) Helix-turn-helix
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
TIGR00773 (2/3) Na+/H+ antiporter NhaA
PF13462 (2/3) Thioredoxin
PF06965 (2/3) Na+/H+ antiporter 1
jaccard_groups_3388 508.74 +- 463.90 7 0 0 0 0.02 +- 0.03 7 5

PF04069 (7/7) Substrate binding domain of ABC-type glycine betaine transport system
PF03781 (7/7) Sulfatase-modifying factor enzyme 1
PF00884 (7/7) Sulfatase
PF03466 (6/7) LysR substrate binding domain
PF00126 (6/7) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3387 128.04 +- 0.96 2 0 0 0 0.05 +- 0.06 2 15

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13364 (2/2) Beta-galactosidase jelly roll domain
PF13363 (2/2) Beta-galactosidase, domain 3
PF13320 (2/2) Domain of unknown function (DUF4091)
PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF10435 (2/2) Beta-galactosidase, domain 2
PF08305 (2/2) NPCBM/NEW2 domain
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF01301 (2/2) Glycosyl hydrolases family 35
PF01120 (2/2) Alpha-L-fucosidase
PF01055 (2/2) Glycosyl hydrolases family 31
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF01380 (1/2) SIS domain
jaccard_groups_3386 273.84 +- 106.57 7 0 1 0 0.03 +- 0.01 7 7

PF07690 (7/7) Major Facilitator Superfamily
PF05378 (7/7) Hydantoinase/oxoprolinase N-terminal region
PF02538 (7/7) Hydantoinase B/oxoprolinase
PF01968 (7/7) Hydantoinase/oxoprolinase
PF01380 (7/7) SIS domain
PF01019 (7/7) Gamma-glutamyltranspeptidase
PF00294 (7/7) pfkB family carbohydrate kinase
jaccard_groups_4829 66.10 +- 16.89 3 0 0 0 0.22 +- 0.29 3 10

PF13777 (3/3) Domain of unknown function (DUF4173)
PF13460 (3/3) NAD(P)H-binding
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02861 (3/3) Clp amino terminal domain, pathogenicity island component
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00067 (3/3) Cytochrome P450
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
jaccard_groups_3384 130.37 +- 42.30 7 0 0 0 0.08 +- 0.12 7 6

PF01058 (7/7) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (7/7) Nickel-dependent hydrogenase
PF00361 (7/7) Proton-conducting membrane transporter
PF00346 (7/7) Respiratory-chain NADH dehydrogenase, 49 Kd subunit
PF00329 (7/7) Respiratory-chain NADH dehydrogenase, 30 Kd subunit
PF00146 (7/7) NADH dehydrogenase
jaccard_groups_3383 402.64 +- 395.93 6 0 4 0 0.02 +- 0.03 6 10

TIGR01136 (6/6) cysteine synthase
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF18603 (5/6) L-amino acid ligase C-terminal domain 2
PF13535 (5/6) ATP-grasp domain
PF01361 (5/6) Tautomerase enzyme
PF00132 (5/6) Bacterial transferase hexapeptide (six repeats)
PF07690 (4/6) Major Facilitator Superfamily
PF03358 (4/6) NADPH-dependent FMN reductase
PF02786 (4/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF18130 (3/6) ATP-grasp N-terminal domain
jaccard_groups_3382 106.76 +- 57.27 6 0 0 0 0.08 +- 0.14 6 8

TIGR00350 (6/6) cell envelope-related function transcriptional attenuator common domain
PF13399 (6/6) LytR cell envelope-related transcriptional attenuator
PF07859 (6/6) alpha/beta hydrolase fold
PF03816 (6/6) Cell envelope-related transcriptional attenuator domain
PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent
PF01258 (6/6) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (6/6) D-alanyl-D-alanine carboxypeptidase
PF00459 (6/6) Inositol monophosphatase family
jaccard_groups_6281 1078.07 +- 82.93 2 0 2 0 0.01 +- 0.00 2 21

TIGR04171 (2/2) ribonucleoside-diphosphate reductase, class 1b, beta subunit
TIGR04170 (2/2) ribonucleoside-diphosphate reductase, class 1b, alpha subunit
TIGR02124 (2/2) hydrogenase expression/formation protein HypE
TIGR00143 (2/2) carbamoyltransferase HypF
PF17788 (2/2) HypF Kae1-like domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF08343 (2/2) Ribonucleotide reductase N-terminal
PF07690 (2/2) Major Facilitator Superfamily
PF07503 (2/2) HypF finger
PF05977 (2/2) Transmembrane secretion effector
PF04167 (2/2) Protein of unknown function (DUF402)
PF02867 (2/2) Ribonucleotide reductase, barrel domain
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01300 (2/2) Telomere recombination
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00857 (2/2) Isochorismatase family
PF00708 (2/2) Acylphosphatase
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00317 (2/2) Ribonucleotide reductase, all-alpha domain
PF00268 (2/2) Ribonucleotide reductase, small chain
jaccard_groups_6284 1354.09 +- 64.09 2 0 0 0 0.01 +- 0.00 2 10

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF14832 (2/2) Putative oxalocrotonate tautomerase enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF00892 (2/2) EamA-like transporter family
PF00857 (2/2) Isochorismatase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
jaccard_groups_3018 15.97 +- 3.83 3 0 0 0 0.13 +- 0.09 3 4

PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF01425 (3/3) Amidase
PF01411 (3/3) tRNA synthetases class II (A)
PF00474 (3/3) Sodium:solute symporter family
jaccard_groups_6289 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
jaccard_groups_6288 1258.84 +- 54.84 2 0 2 0 0.02 +- 0.05 2 9

TIGR00830 (2/2) PTS system, glucose subfamily, IIA component
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00069 (2/2) Protein kinase domain
jaccard_groups_3011 281.67 +- 108.33 2 0 1 0 0.01 +- 0.01 2 6

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
PF13535 (2/2) ATP-grasp domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
jaccard_groups_6527 125.54 +- 44.96 2 0 1 0 0.06 +- 0.09 2 11

PF14759 (2/2) Reductase C-terminal
PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF12704 (2/2) MacB-like periplasmic core domain
PF09471 (2/2) IgA Peptidase M64
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02687 (2/2) FtsX-like permease family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
jaccard_groups_765 166.86 +- 93.14 2 0 0 0 0.02 +- 0.02 2 3

PF03640 (2/2) Secreted repeat of unknown function
PF00107 (1/2) Zinc-binding dehydrogenase
PF00089 (1/2) Trypsin
jaccard_groups_3492 46.38 +- 25.63 6 0 0 0 0.11 +- 0.10 6 6

PF10633 (6/6) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF07729 (6/6) FCD domain
PF05448 (6/6) Acetyl xylan esterase (AXE1)
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF13088 (3/6) BNR repeat-like domain
PF01494 (3/6) FAD binding domain
jaccard_groups_6197 411.41 +- 362.59 2 0 0 0 0.07 +- 0.17 2 11

TIGR00673 (2/2) cyanase
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF09587 (2/2) Bacterial capsule synthesis protein PGA_cap
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01565 (2/2) FAD binding domain
PF00899 (2/2) ThiF family
PF00206 (2/2) Lyase
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
jaccard_groups_766 78.03 +- 51.25 4 0 0 0 0.04 +- 0.04 4 2

PF00884 (4/4) Sulfatase
PF03781 (2/4) Sulfatase-modifying factor enzyme 1
jaccard_groups_761 475.13 +- 371.47 38 0 14 31 0.07 +- 0.15 38 20

PF05331 (38/38) Protein of unknown function (DUF742)
PF03259 (38/38) Roadblock/LC7 domain
PF03029 (38/38) Conserved hypothetical ATP binding protein
PF00293 (36/38) NUDIX domain
PF02771 (34/38) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (34/38) Acyl-CoA dehydrogenase, middle domain
PF01590 (34/38) GAF domain
PF00441 (34/38) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (32/38) ABC transporter
TIGR03891 (31/38) thiopeptide-type bacteriocin biosynthesis domain
PF04738 (31/38) Lantibiotic dehydratase, N terminus
TIGR04364 (30/38) methyltransferase, FxLD system
TIGR04363 (30/38) FxLD family lantipeptide
PF14028 (30/38) Lantibiotic biosynthesis dehydratase C-term
PF05147 (30/38) Lanthionine synthetase C-like protein
PF01135 (30/38) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF02518 (28/38) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00723 (27/38) Glycosyl hydrolases family 15
PF13649 (21/38) Methyltransferase domain
PF01427 (20/38) D-ala-D-ala dipeptidase
jaccard_groups_763 979.07 +- 916.50 103 28 75 102 0.04 +- 0.14 75 7

PF00005 (103/103) ABC transporter
PF13575 (102/103) Domain of unknown function (DUF4135)
PF05147 (102/103) Lanthionine synthetase C-like protein
PF00664 (102/103) ABC transporter transmembrane region
PF03412 (101/103) Peptidase C39 family
TIGR03897 (97/103) type 2 lantibiotic biosynthesis protein LanM
PF14867 (55/103) Lantibiotic alpha
jaccard_groups_3498 380.10 +- 185.68 4 0 0 0 0.02 +- 0.01 4 6

PF14200 (4/4) Ricin-type beta-trefoil lectin domain-like
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF14498 (3/4) Glycosyl hydrolase family 65, N-terminal domain
PF07994 (3/4) Myo-inositol-1-phosphate synthase
PF03664 (3/4) Glycosyl hydrolase family 62
jaccard_groups_3651 278.54 +- 225.49 6 0 0 0 0.04 +- 0.10 6 9

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF01408 (6/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF13669 (5/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13377 (5/6) Periplasmic binding protein-like domain
PF07690 (5/6) Major Facilitator Superfamily
PF00356 (5/6) Bacterial regulatory proteins, lacI family
PF13613 (3/6) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (3/6) DDE superfamily endonuclease
jaccard_groups_3650 503.89 +- 107.28 6 0 6 1 0.01 +- 0.00 6 6

PF13640 (6/6) 2OG-Fe(II) oxygenase superfamily
PF13350 (6/6) Tyrosine phosphatase family
PF07690 (6/6) Major Facilitator Superfamily
PF00275 (6/6) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF01142 (5/6) tRNA pseudouridine synthase D (TruD)
PF00106 (5/6) short chain dehydrogenase
jaccard_groups_3121 800.24 +- 730.22 6 0 6 0 0.03 +- 0.13 6 18

TIGR02814 (6/6) PfaD family protein
PF07977 (6/6) FabA-like domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF14765 (5/6) Polyketide synthase dehydratase
PF08659 (5/6) KR domain
PF03060 (5/6) Nitronate monooxygenase
PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain
PF00975 (5/6) Thioesterase domain
PF00698 (5/6) Acyl transferase domain
PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain
PF18328 (4/6) Fatty acid synthase subunit PfaD N-terminal domain
PF16197 (4/6) Ketoacyl-synthetase C-terminal extension
PF01593 (4/6) Flavin containing amine oxidoreductase
TIGR02813 (3/6) polyketide-type polyunsaturated fatty acid synthase PfaA
PF02771 (3/6) Acyl-CoA dehydrogenase, N-terminal domain
PF01648 (3/6) 4'-phosphopantetheinyl transferase superfamily
jaccard_groups_3120 270.96 +- 138.38 6 0 0 0 0.02 +- 0.04 6 5

PF07690 (6/6) Major Facilitator Superfamily
PF03781 (6/6) Sulfatase-modifying factor enzyme 1
PF00884 (5/6) Sulfatase
PF13472 (4/6) GDSL-like Lipase/Acylhydrolase family
PF03551 (4/6) Transcriptional regulator PadR-like family
jaccard_groups_3655 98.30 +- 29.81 6 0 6 0 0.09 +- 0.27 6 13

TIGR01099 (6/6) UTP--glucose-1-phosphate uridylyltransferase
PF17914 (6/6) HopA1 effector protein family
PF13546 (6/6) DDE superfamily endonuclease
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF08028 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF02195 (6/6) ParB-like nuclease domain
PF01613 (6/6) Flavin reductase like domain
PF00982 (6/6) Glycosyltransferase family 20
PF00483 (6/6) Nucleotidyl transferase
PF00296 (6/6) Luciferase-like monooxygenase
PF02894 (5/6) Oxidoreductase family, C-terminal alpha/beta domain
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF01636 (4/6) Phosphotransferase enzyme family
jaccard_groups_3657 645.08 +- 73.65 5 0 4 0 0.01 +- 0.03 5 17

TIGR01679 (5/5) FAD-linked oxidoreductase
TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR01122 (5/5) branched-chain amino acid aminotransferase
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF08666 (5/5) SAF domain
PF04321 (5/5) RmlD substrate binding domain
PF04030 (5/5) D-arabinono-1,4-lactone oxidase
PF03737 (5/5) Aldolase/RraA
PF03102 (5/5) NeuB family
PF02780 (5/5) Transketolase, C-terminal domain
PF02779 (5/5) Transketolase, pyrimidine binding domain
PF01565 (5/5) FAD binding domain
PF01063 (5/5) Amino-transferase class IV
PF00456 (5/5) Transketolase, thiamine diphosphate binding domain
TIGR00473 (3/5) CDP-diacylglycerol-serine O-phosphatidyltransferase
PF01066 (3/5) CDP-alcohol phosphatidyltransferase
jaccard_groups_3124 321.97 +- 199.60 8 0 5 0 0.02 +- 0.04 8 4

PF02515 (8/8) CoA-transferase family III
PF00465 (8/8) Iron-containing alcohol dehydrogenase
PF00248 (8/8) Aldo/keto reductase family
PF00067 (8/8) Cytochrome P450
jaccard_groups_2700 569.88 +- 178.51 3 0 3 3 0.01 +- 0.00 3 4

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (3/3) Radical SAM superfamily
PF00248 (3/3) Aldo/keto reductase family
PF12746 (2/3) GNAT acetyltransferase
jaccard_groups_3129 789.47 +- 163.41 5 0 5 5 0.01 +- 0.02 5 9

TIGR04085 (5/5) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF08241 (5/5) Methyltransferase domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF01980 (5/5) tRNA-methyltransferase O
PF01494 (5/5) FAD binding domain
PF17920 (4/5) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/5) Bacterial regulatory proteins, tetR family
jaccard_groups_2704 89.37 +- 34.21 4 0 3 0 0.06 +- 0.11 4 5

PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF03777 (3/4) ChpA-C
PF03559 (3/4) NDP-hexose 2,3-dehydratase
PF00908 (3/4) dTDP-4-dehydrorhamnose 3,5-epimerase
jaccard_groups_2705 435.68 +- 245.53 11 0 10 0 0.01 +- 0.01 11 4

PF04324 (11/11) BFD-like [2Fe-2S] binding domain
PF00551 (11/11) Formyl transferase
PF00334 (11/11) Nucleoside diphosphate kinase
PF00202 (11/11) Aminotransferase class-III
jaccard_groups_2707 72.27 +- 14.68 2 0 0 0 0.08 +- 0.08 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09851 (2/2) Short C-terminal domain
PF05199 (2/2) GMC oxidoreductase
PF04199 (2/2) Putative cyclase
PF02322 (2/2) Cytochrome bd terminal oxidase subunit II
PF01654 (2/2) Cytochrome bd terminal oxidase subunit I
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00732 (2/2) GMC oxidoreductase
PF00654 (2/2) Voltage gated chloride channel
TIGR01313 (1/2) carbohydrate kinase, thermoresistant glucokinase family
PF11139 (1/2) Sap, sulfolipid-1-addressing protein
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF06314 (1/2) Acetoacetate decarboxylase (ADC)
PF01263 (1/2) Aldose 1-epimerase
PF01202 (1/2) Shikimate kinase
jaccard_groups_6511 274.29 +- 122.63 2 0 0 0 0.03 +- 0.02 2 23

PF17677 (2/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF14310 (2/2) Fibronectin type III-like domain
PF13551 (2/2) Winged helix-turn helix
PF13378 (2/2) Enolase C-terminal domain-like
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09339 (2/2) IclR helix-turn-helix domain
PF09261 (2/2) Alpha mannosidase middle domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (2/2) Trehalose utilisation
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02368 (2/2) Bacterial Ig-like domain (group 2)
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00480 (2/2) ROK family
PF18368 (1/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF14498 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00754 (1/2) F5/8 type C domain
PF00703 (1/2) Glycosyl hydrolases family 2
jaccard_groups_2015 142.41 +- 72.76 2 0 2 0 0.06 +- 0.04 2 5

PF13833 (2/2) EF-hand domain pair
PF13499 (2/2) EF-hand domain pair
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07969 (2/2) Amidohydrolase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_2016 417.16 +- 210.81 2 0 0 0 0.02 +- 0.03 2 18

TIGR01725 (2/2) phage protein, HK97 gp10 family
PF16461 (2/2) Lambda phage tail tube protein, TTP
PF11367 (2/2) Protein of unknown function (DUF3168)
PF05133 (2/2) Phage portal protein, SPP1 Gp6-like
PF04883 (2/2) Bacteriophage HK97-gp10, putative tail-component
PF16945 (1/2) Putative lactococcus lactis phage r1t holin
PF13560 (1/2) Helix-turn-helix domain
PF13384 (1/2) Homeodomain-like domain
PF13227 (1/2) Protein of unknown function (DUF4035)
PF12307 (1/2) Protein of unknown function (DUF3631)
PF10935 (1/2) Protein of unknown function (DUF2637)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF05521 (1/2) Phage head-tail joining protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01391 (1/2) Collagen triple helix repeat (20 copies)
PF01183 (1/2) Glycosyl hydrolases family 25
PF00293 (1/2) NUDIX domain
PF00271 (1/2) Helicase conserved C-terminal domain
jaccard_groups_6512 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2010 212.59 +- 134.71 15 0 1 0 0.04 +- 0.05 15 9

PF17042 (15/15) Nucleotide-binding C-terminal domain
PF14833 (15/15) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07005 (15/15) Sugar-binding N-terminal domain
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF07729 (14/15) FCD domain
PF00392 (14/15) Bacterial regulatory proteins, gntR family
TIGR00167 (9/15) ketose-bisphosphate aldolase
PF02447 (9/15) GntP family permease
PF01116 (9/15) Fructose-bisphosphate aldolase class-II
jaccard_groups_2013 169.59 +- 211.99 15 0 2 0 0.08 +- 0.15 15 7

TIGR04316 (15/15) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF01474 (15/15) Class-II DAHP synthetase family
PF00857 (15/15) Isochorismatase family
PF00425 (15/15) chorismate binding enzyme
PF00117 (15/15) Glutamine amidotransferase class-I
PF00106 (9/15) short chain dehydrogenase
PF13561 (8/15) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_308 105.41 +- 137.19 14 0 2 0 0.09 +- 0.18 14 2

PF02627 (14/14) Carboxymuconolactone decarboxylase family
TIGR00778 (11/14) alkylhydroperoxidase AhpD family core domain
jaccard_groups_6048 509.69 +- 54.69 2 0 2 0 0.01 +- 0.00 2 9

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
jaccard_groups_2384 233.91 +- 156.82 10 0 2 0 0.03 +- 0.03 10 6

PF14525 (10/10) AraC-binding-like domain
PF12833 (10/10) Helix-turn-helix domain
PF08240 (10/10) Alcohol dehydrogenase GroES-like domain
PF07883 (10/10) Cupin domain
PF00107 (10/10) Zinc-binding dehydrogenase
PF07690 (7/10) Major Facilitator Superfamily
jaccard_groups_2382 25.48 +- 4.09 9 0 0 0 0.12 +- 0.14 9 4

PF04909 (9/9) Amidohydrolase
PF00248 (9/9) Aldo/keto reductase family
PF02653 (7/9) Branched-chain amino acid transport system / permease component
PF13561 (5/9) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_2838 246.90 +- 180.63 9 0 9 0 0.11 +- 0.23 9 19

TIGR02980 (9/9) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
TIGR01733 (9/9) amino acid adenylation domain
TIGR01720 (9/9) non-ribosomal peptide synthase domain TIGR01720
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF12401 (9/9) Protein of unknown function (DUF2662)
PF04545 (9/9) Sigma-70, region 4
PF04542 (9/9) Sigma-70 region 2
PF04539 (9/9) Sigma-70 region 3
PF02518 (9/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01061 (9/9) ABC-2 type transporter
PF00672 (9/9) HAMP domain
PF00668 (9/9) Condensation domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00512 (9/9) His Kinase A (phospho-acceptor) domain
PF00501 (9/9) AMP-binding enzyme
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00072 (9/9) Response regulator receiver domain
PF00005 (9/9) ABC transporter
PF17196 (8/9) Protein of unknown function (DUF5133)
jaccard_groups_2839 17.35 +- 7.64 7 0 0 0 0.18 +- 0.31 7 8

TIGR00105 (7/7) ribosomal protein bL31
PF02770 (7/7) Acyl-CoA dehydrogenase, middle domain
PF01756 (7/7) Acyl-CoA oxidase
PF01197 (7/7) Ribosomal protein L31
PF00583 (7/7) Acetyltransferase (GNAT) family
PF01497 (5/7) Periplasmic binding protein
PF01032 (5/7) FecCD transport family
PF00005 (5/7) ABC transporter
jaccard_groups_3727 37.77 +- 11.82 4 0 1 0 0.17 +- 0.29 4 7

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF00501 (4/4) AMP-binding enzyme
PF00248 (4/4) Aldo/keto reductase family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/4) ABC transporter transmembrane region
PF00005 (3/4) ABC transporter
jaccard_groups_3720 356.68 +- 203.56 5 0 0 0 0.04 +- 0.15 5 8

PF11723 (5/5) Homotrimeric ring hydroxylase
PF02900 (5/5) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (5/5) Peptidase family M20/M25/M40
PF00561 (5/5) alpha/beta hydrolase fold
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF12697 (3/5) Alpha/beta hydrolase family
PF00175 (3/5) Oxidoreductase NAD-binding domain
jaccard_groups_6143 16.61 +- 3.50 2 0 0 0 0.19 +- 0.25 2 8

TIGR01472 (2/2) GDP-mannose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF04149 (2/2) Domain of unknown function (DUF397)
PF00535 (2/2) Glycosyl transferase family 2
PF13560 (1/2) Helix-turn-helix domain
PF00872 (1/2) Transposase, Mutator family
PF00561 (1/2) alpha/beta hydrolase fold
PF00069 (1/2) Protein kinase domain
jaccard_groups_5895 26.80 +- 1.64 2 0 0 2 0.15 +- 0.24 2 11

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14404 (2/2) Ribosomally synthesized peptide in Streptomyces species
PF13405 (2/2) EF-hand domain
PF13202 (2/2) EF hand
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF09471 (2/2) IgA Peptidase M64
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01593 (2/2) Flavin containing amine oxidoreductase
PF13833 (1/2) EF-hand domain pair
PF13499 (1/2) EF-hand domain pair
jaccard_groups_5891 31.48 +- 1.93 2 0 0 0 0.13 +- 0.13 2 8

PF17128 (2/2) Domain of unknown function (DUF5107)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12840 (2/2) Helix-turn-helix domain
PF11706 (2/2) CGNR zinc finger
PF07336 (2/2) Putative stress-induced transcription regulator
PF05977 (2/2) Transmembrane secretion effector
PF13411 (1/2) MerR HTH family regulatory protein
PF07739 (1/2) TipAS antibiotic-recognition domain
jaccard_groups_5890 1082.69 +- 858.64 2 0 1 0 0.06 +- 0.20 2 16

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF04909 (2/2) Amidohydrolase
PF03737 (2/2) Aldolase/RraA
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02515 (2/2) CoA-transferase family III
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF16655 (1/2) PhoD-like phosphatase, N-terminal domain
PF13560 (1/2) Helix-turn-helix domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF09423 (1/2) PhoD-like phosphatase
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01547 (1/2) Bacterial extracellular solute-binding protein
jaccard_groups_5898 600.85 +- 188.32 2 0 0 0 0.03 +- 0.04 2 20

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (2/2) Rrf2 family protein
PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (2/2) Thioredoxin
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (2/2) Transcriptional regulator
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (2/2) Molybdopterin oxidoreductase
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08386 (1/2) TAP-like protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01909 (1/2) Nucleotidyltransferase domain
jaccard_groups_5545 893.37 +- 424.28 2 0 2 0 0.01 +- 0.02 2 24

TIGR01733 (2/2) amino acid adenylation domain
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12802 (2/2) MarR family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01613 (2/2) Flavin reductase like domain
PF01474 (2/2) Class-II DAHP synthetase family
PF00975 (2/2) Thioesterase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_5435 172.50 +- 22.50 2 0 0 0 0.02 +- 0.02 2 6

TIGR02089 (2/2) tartrate dehydrogenase
PF14330 (2/2) Domain of unknown function (DUF4387)
PF07690 (2/2) Major Facilitator Superfamily
PF07287 (2/2) Acyclic terpene utilisation family protein AtuA
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
jaccard_groups_5431 412.94 +- 0.00 2 0 0 0 0.03 +- 0.02 2 11

PF13407 (2/2) Periplasmic binding protein domain
PF07729 (2/2) FCD domain
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01979 (2/2) Amidohydrolase family
PF01968 (2/2) Hydantoinase/oxoprolinase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
jaccard_groups_619 463.58 +- 501.24 3 0 0 0 0.09 +- 0.12 3 5

PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF00005 (3/3) ABC transporter
jaccard_groups_5946 1342.00 +- 1238.00 2 0 2 0 0.07 +- 0.23 2 19

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00083 (2/2) Sugar (and other) transporter
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01751 (1/2) crotonyl-CoA carboxylase/reductase
PF16864 (1/2) Dimerisation domain
PF08241 (1/2) Methyltransferase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00668 (1/2) Condensation domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00107 (1/2) Zinc-binding dehydrogenase
jaccard_groups_5945 1165.50 +- 4.50 2 0 0 0 0.01 +- 0.00 2 16

PF17645 (2/2) Arylmalonate decarboxylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (2/2) FCD domain
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00866 (2/2) Ring hydroxylating beta subunit
PF00857 (2/2) Isochorismatase family
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00355 (2/2) Rieske [2Fe-2S] domain
jaccard_groups_5943 88.43 +- 21.02 2 0 0 0 0.03 +- 0.04 2 9

TIGR01840 (2/2) esterase, PHB depolymerase family
PF18143 (2/2) HAD domain in Swiss Army Knife RNA repair proteins
PF13279 (2/2) Thioesterase-like superfamily
PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF09362 (2/2) Domain of unknown function (DUF1996)
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF03713 (2/2) Domain of unknown function (DUF305)
jaccard_groups_5940 552.65 +- 97.35 2 0 0 0 0.03 +- 0.05 2 11

TIGR03211 (2/2) catechol 2,3 dioxygenase
PF09084 (2/2) NMT1/THI5 like
PF07690 (2/2) Major Facilitator Superfamily
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
jaccard_groups_611 17.57 +- 4.65 5 0 0 0 0.20 +- 0.37 5 7

TIGR02605 (5/5) putative regulatory protein, FmdB family
TIGR01694 (5/5) methylthioadenosine phosphorylase
PF09723 (5/5) Zinc ribbon domain
PF01048 (5/5) Phosphorylase superfamily
TIGR00220 (3/5) large conductance mechanosensitive channel protein
PF07690 (3/5) Major Facilitator Superfamily
PF01741 (3/5) Large-conductance mechanosensitive channel, MscL
jaccard_groups_610 223.46 +- 204.90 15 0 12 2 0.04 +- 0.09 15 2

PF00891 (15/15) O-methyltransferase domain
PF16864 (9/15) Dimerisation domain
jaccard_groups_2855 39.26 +- 13.09 3 0 0 0 0.16 +- 0.24 3 5

TIGR00738 (3/3) Rrf2 family protein
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02082 (3/3) Transcriptional regulator
PF01925 (2/3) Sulfite exporter TauE/SafE
PF00486 (2/3) Transcriptional regulatory protein, C terminal
jaccard_groups_614 94.16 +- 114.26 13 0 0 0 0.18 +- 0.29 13 11

PF13231 (13/13) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF04138 (13/13) GtrA-like protein
PF02518 (13/13) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (13/13) HAMP domain
PF00512 (13/13) His Kinase A (phospho-acceptor) domain
PF00535 (12/13) Glycosyl transferase family 2
PF02909 (10/13) Tetracyclin repressor-like, C-terminal domain
PF00440 (10/13) Bacterial regulatory proteins, tetR family
PF07690 (9/13) Major Facilitator Superfamily
PF00486 (9/13) Transcriptional regulatory protein, C terminal
PF00072 (9/13) Response regulator receiver domain
jaccard_groups_616 256.24 +- 235.45 59 3 55 0 0.04 +- 0.10 56 5

PF13649 (59/59) Methyltransferase domain
PF00005 (59/59) ABC transporter
PF12697 (57/59) Alpha/beta hydrolase family
PF00664 (43/59) ABC transporter transmembrane region
PF13450 (32/59) NAD(P)-binding Rossmann-like domain
jaccard_groups_2522 321.08 +- 206.40 11 0 4 0 0.10 +- 0.21 11 14

TIGR00928 (11/11) adenylosuccinate lyase
TIGR00711 (11/11) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (11/11) Acetyltransferase (GNAT) domain
PF07690 (11/11) Major Facilitator Superfamily
PF01425 (11/11) Amidase
PF00486 (11/11) Transcriptional regulatory protein, C terminal
PF00206 (11/11) Lyase
PF00120 (11/11) Glutamine synthetase, catalytic domain
PF00072 (11/11) Response regulator receiver domain
PF12800 (10/11) 4Fe-4S binding domain
PF01814 (10/11) Hemerythrin HHE cation binding domain
PF13460 (6/11) NAD(P)H-binding
PF01494 (6/11) FAD binding domain
PF00561 (6/11) alpha/beta hydrolase fold
jaccard_groups_1225 292.12 +- 449.48 5 0 0 0 0.08 +- 0.14 5 6

PF18080 (5/5) Galactose mutarotase-like fold domain
PF17974 (5/5) Galactose-binding domain-like
PF17451 (5/5) Glycosyl hydrolase 101 beta sandwich domain
PF12905 (5/5) Endo-alpha-N-acetylgalactosaminidase
PF10633 (4/5) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF08305 (4/5) NPCBM/NEW2 domain
jaccard_groups_2529 207.27 +- 126.62 13 0 8 0 0.07 +- 0.20 13 9

TIGR00711 (13/13) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13577 (13/13) SnoaL-like domain
PF07690 (13/13) Major Facilitator Superfamily
PF07366 (13/13) SnoaL-like polyketide cyclase
TIGR00026 (12/13) deazaflavin-dependent oxidoreductase, nitroreductase family
PF03358 (12/13) NADPH-dependent FMN reductase
PF01814 (12/13) Hemerythrin HHE cation binding domain
PF00999 (12/13) Sodium/hydrogen exchanger family
PF00891 (7/13) O-methyltransferase domain
jaccard_groups_1223 66.92 +- 122.61 30 0 10 0 0.11 +- 0.12 30 5

PF04324 (30/30) BFD-like [2Fe-2S] binding domain
PF02782 (30/30) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (30/30) FAD dependent oxidoreductase
PF00370 (30/30) FGGY family of carbohydrate kinases, N-terminal domain
PF07992 (28/30) Pyridine nucleotide-disulphide oxidoreductase
jaccard_groups_5094 129.87 +- 35.67 3 0 3 0 0.13 +- 0.30 3 19

TIGR03026 (3/3) nucleotide sugar dehydrogenase
TIGR01733 (3/3) amino acid adenylation domain
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13469 (3/3) Sulfotransferase family
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF01522 (3/3) Polysaccharide deacetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00196 (3/3) Bacterial regulatory proteins, luxR family
jaccard_groups_5763 126.16 +- 12.76 2 0 2 0 0.17 +- 0.31 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF05534 (2/2) HicB family
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
jaccard_groups_5090 478.35 +- 240.45 3 0 0 0 0.02 +- 0.02 3 6

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (3/3) Major Facilitator Superfamily
PF04954 (3/3) Siderophore-interacting protein
PF03704 (3/3) Bacterial transcriptional activator domain
PF01638 (3/3) HxlR-like helix-turn-helix
PF00296 (3/3) Luciferase-like monooxygenase
jaccard_groups_1977 61.09 +- 12.11 3 0 0 0 0.20 +- 0.37 3 11

TIGR01525 (3/3) heavy metal translocating P-type ATPase
PF13649 (3/3) Methyltransferase domain
PF03965 (3/3) Penicillinase repressor
PF02583 (3/3) Metal-sensitive transcriptional repressor
PF01475 (3/3) Ferric uptake regulator family
PF01435 (3/3) Peptidase family M48
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00403 (3/3) Heavy-metal-associated domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00122 (3/3) E1-E2 ATPase
jaccard_groups_909 62.94 +- 8.54 3 0 1 0 0.12 +- 0.22 3 6

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13419 (2/3) Haloacid dehalogenase-like hydrolase
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
jaccard_groups_908 143.28 +- 115.78 4 0 0 0 0.04 +- 0.06 4 2

PF10056 (4/4) Uncharacterized conserved protein (DUF2293)
PF08592 (4/4) Domain of unknown function (DUF1772)
jaccard_groups_905 19.36 +- 14.48 12 0 0 0 0.20 +- 0.36 12 6

PF12806 (12/12) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (12/12) Acyl-CoA dehydrogenase N terminal
PF02770 (12/12) Acyl-CoA dehydrogenase, middle domain
PF00441 (12/12) Acyl-CoA dehydrogenase, C-terminal domain
PF00775 (10/12) Dioxygenase
PF13641 (8/12) Glycosyltransferase like family 2
jaccard_groups_5380 136.23 +- 2.56 2 0 1 0 0.12 +- 0.19 2 15

PF14592 (2/2) Chondroitinase B
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13378 (2/2) Enolase C-terminal domain-like
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07729 (2/2) FCD domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01120 (2/2) Alpha-L-fucosidase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
jaccard_groups_907 30.36 +- 11.51 9 0 0 0 0.21 +- 0.32 9 7

TIGR01460 (9/9) HAD hydrolase, family IIA
PF13344 (9/9) Haloacid dehalogenase-like hydrolase
PF13242 (9/9) HAD-hyrolase-like
PF04203 (9/9) Sortase domain
PF01145 (6/9) SPFH domain / Band 7 family
PF03067 (5/9) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01663 (5/9) Type I phosphodiesterase / nucleotide pyrophosphatase
jaccard_groups_5382 163.67 +- 94.33 2 0 0 0 0.02 +- 0.01 2 4

PF12697 (2/2) Alpha/beta hydrolase family
PF10012 (2/2) Uncharacterized protein conserved in bacteria (DUF2255)
PF01738 (2/2) Dienelactone hydrolase family
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_902 110.98 +- 121.84 11 0 2 0 0.08 +- 0.10 11 4

PF04261 (11/11) Dyp-type peroxidase family
TIGR01412 (10/11) Tat-translocated enzyme
PF09375 (10/11) Imelysin
PF04185 (8/11) Phosphoesterase family
jaccard_groups_1500 8.57 +- 0.00 2 0 0 0 0.23 +- 0.31 2 3

TIGR02469 (2/2) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
TIGR01465 (2/2) precorrin-4 C11-methyltransferase
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
jaccard_groups_1505 79.07 +- 52.58 32 0 0 0 0.09 +- 0.08 32 9

PF13581 (32/32) Histidine kinase-like ATPase domain
PF13492 (32/32) GAF domain
PF08447 (32/32) PAS fold
PF07228 (32/32) Stage II sporulation protein E (SpoIIE)
PF00149 (32/32) Calcineurin-like phosphoesterase
PF09348 (31/32) Domain of unknown function (DUF1990)
PF14158 (28/32) YndJ-like protein
PF11716 (28/32) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03446 (28/32) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_3668 75.84 +- 26.73 3 0 0 0 0.04 +- 0.05 3 6

TIGR03510 (3/3) XapX domain
PF07883 (3/3) Cupin domain
PF07859 (3/3) alpha/beta hydrolase fold
PF07235 (3/3) Protein of unknown function (DUF1427)
PF12802 (2/3) MarR family
PF04909 (2/3) Amidohydrolase
jaccard_groups_831 171.31 +- 116.16 67 0 25 4 0.09 +- 0.11 67 5

PF00528 (67/67) Binding-protein-dependent transport system inner membrane component
PF02826 (66/67) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF13377 (65/67) Periplasmic binding protein-like domain
PF01547 (64/67) Bacterial extracellular solute-binding protein
PF08220 (39/67) DeoR-like helix-turn-helix domain
jaccard_groups_3542 317.89 +- 271.23 4 0 1 0 0.05 +- 0.15 4 8

PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF01636 (4/4) Phosphotransferase enzyme family
PF00202 (4/4) Aminotransferase class-III
PF00171 (4/4) Aldehyde dehydrogenase family
PF07702 (3/4) UTRA domain
PF03319 (3/4) Ethanolamine utilisation protein EutN/carboxysome
PF00936 (3/4) BMC domain
PF00392 (3/4) Bacterial regulatory proteins, gntR family
jaccard_groups_1734 12.23 +- 1.85 3 0 0 3 0.16 +- 0.13 3 5

TIGR02493 (3/3) pyruvate formate-lyase 1-activating enzyme
PF04055 (3/3) Radical SAM superfamily
PF02901 (3/3) Pyruvate formate lyase-like
PF01228 (3/3) Glycine radical
TIGR01255 (2/3) formate acetyltransferase
jaccard_groups_1735 32.38 +- 10.98 3 0 0 0 0.11 +- 0.11 3 4

PF12802 (3/3) MarR family
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF00925 (3/3) GTP cyclohydrolase II
PF01551 (2/3) Peptidase family M23
jaccard_groups_1736 271.61 +- 243.14 27 0 27 0 0.14 +- 0.28 27 20

PF13193 (27/27) AMP-binding enzyme C-terminal domain
PF03621 (27/27) MbtH-like protein
PF02668 (27/27) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (27/27) Condensation domain
PF00550 (27/27) Phosphopantetheine attachment site
PF00501 (27/27) AMP-binding enzyme
PF00196 (27/27) Bacterial regulatory proteins, luxR family
PF00144 (27/27) Beta-lactamase
PF00072 (27/27) Response regulator receiver domain
PF00005 (27/27) ABC transporter
TIGR01733 (26/27) amino acid adenylation domain
TIGR01720 (26/27) non-ribosomal peptide synthase domain TIGR01720
PF12840 (26/27) Helix-turn-helix domain
PF07730 (26/27) Histidine kinase
TIGR04462 (25/27) enduracididine biosynthesis enzyme MppP
TIGR04460 (25/27) enduracididine biosynthesis enzyme MppR
PF06314 (25/27) Acetoacetate decarboxylase (ADC)
PF05977 (25/27) Transmembrane secretion effector
PF00155 (25/27) Aminotransferase class I and II
PF12698 (18/27) ABC-2 family transporter protein
jaccard_groups_1730 157.98 +- 7.02 2 0 0 0 0.03 +- 0.05 2 8

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF13560 (1/2) Helix-turn-helix domain
PF13424 (1/2) Tetratricopeptide repeat
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04672 (1/2) S-adenosyl methyltransferase
PF01613 (1/2) Flavin reductase like domain
PF00005 (1/2) ABC transporter
jaccard_groups_1738 57.83 +- 82.54 5 0 0 0 0.10 +- 0.05 5 5

TIGR00167 (5/5) ketose-bisphosphate aldolase
PF08220 (5/5) DeoR-like helix-turn-helix domain
PF01116 (5/5) Fructose-bisphosphate aldolase class-II
PF00455 (5/5) DeoR C terminal sensor domain
PF01380 (4/5) SIS domain
jaccard_groups_163 60.03 +- 69.41 12 0 0 0 0.07 +- 0.09 12 1

PF05685 (12/12) Putative restriction endonuclease
jaccard_groups_3783 21.79 +- 4.26 5 0 0 0 0.09 +- 0.12 5 3

PF14016 (5/5) Protein of unknown function (DUF4232)
PF10604 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF07859 (5/5) alpha/beta hydrolase fold
jaccard_groups_160 177.71 +- 100.51 15 0 0 0 0.03 +- 0.07 15 1

PF01757 (15/15) Acyltransferase family
jaccard_groups_166 62.47 +- 76.67 4 0 0 0 0.13 +- 0.29 4 4

PF00149 (4/4) Calcineurin-like phosphoesterase
PF16656 (2/4) Purple acid Phosphatase, N-terminal domain
PF02872 (2/4) 5'-nucleotidase, C-terminal domain
PF01063 (2/4) Amino-transferase class IV
jaccard_groups_165 152.83 +- 126.32 33 0 5 7 0.04 +- 0.09 33 5

TIGR03026 (33/33) nucleotide sugar dehydrogenase
PF03721 (33/33) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (33/33) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (33/33) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF01370 (17/33) NAD dependent epimerase/dehydratase family
jaccard_groups_164 31.73 +- 54.71 13 0 0 0 0.18 +- 0.35 13 7

PF05425 (13/13) Copper resistance protein D
PF04314 (13/13) Copper chaperone PCu(A)C
PF04234 (13/13) CopC domain
PF02630 (13/13) SCO1/SenC
TIGR01412 (12/13) Tat-translocated enzyme
PF07987 (12/13) Domain of unkown function (DUF1775)
PF04261 (12/13) Dyp-type peroxidase family
jaccard_groups_168 169.89 +- 96.83 5 0 3 0 0.12 +- 0.25 5 2

PF01326 (5/5) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (5/5) PEP-utilising enzyme, mobile domain
jaccard_groups_1429 178.40 +- 389.20 24 0 24 0 0.15 +- 0.20 24 20

PF01041 (22/24) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00201 (22/24) UDP-glucoronosyl and UDP-glucosyl transferase
PF00067 (22/24) Cytochrome P450
TIGR00566 (21/24) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (21/24) aminodeoxychorismate synthase, component I
PF04715 (21/24) Anthranilate synthase component I, N terminal region
PF00975 (21/24) Thioesterase domain
PF00425 (21/24) chorismate binding enzyme
PF00117 (21/24) Glutamine amidotransferase class-I
PF00550 (20/24) Phosphopantetheine attachment site
PF00109 (20/24) Beta-ketoacyl synthase, N-terminal domain
PF00005 (20/24) ABC transporter
PF13193 (19/24) AMP-binding enzyme C-terminal domain
PF02801 (19/24) Beta-ketoacyl synthase, C-terminal domain
PF00501 (19/24) AMP-binding enzyme
PF01061 (18/24) ABC-2 type transporter
PF00698 (18/24) Acyl transferase domain
TIGR01188 (17/24) daunorubicin resistance ABC transporter, ATP-binding protein
PF16197 (17/24) Ketoacyl-synthetase C-terminal extension
PF13370 (15/24) 4Fe-4S single cluster domain of Ferredoxin I
jaccard_groups_1398 333.71 +- 79.60 3 0 0 0 0.01 +- 0.00 3 4

PF05378 (3/3) Hydantoinase/oxoprolinase N-terminal region
PF02538 (3/3) Hydantoinase B/oxoprolinase
PF01968 (3/3) Hydantoinase/oxoprolinase
PF07690 (2/3) Major Facilitator Superfamily
jaccard_groups_4793 372.88 +- 24.22 3 0 1 0 0.01 +- 0.00 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF03061 (2/3) Thioesterase superfamily
jaccard_groups_1392 43.13 +- 19.97 3 0 0 0 0.19 +- 0.29 3 8

TIGR01249 (3/3) prolyl aminopeptidase
PF06821 (3/3) Serine hydrolase
PF04389 (3/3) Peptidase family M28
PF02225 (3/3) PA domain
PF00561 (3/3) alpha/beta hydrolase fold
TIGR03252 (2/3) uncharacterized HhH-GPD family protein
PF00730 (2/3) HhH-GPD superfamily base excision DNA repair protein
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_1422 254.67 +- 198.31 3 0 0 0 0.02 +- 0.05 3 6

PF13560 (3/3) Helix-turn-helix domain
PF12900 (3/3) Pyridoxamine 5'-phosphate oxidase
PF04972 (3/3) BON domain
PF09851 (2/3) Short C-terminal domain
PF07731 (2/3) Multicopper oxidase
PF00571 (2/3) CBS domain
jaccard_groups_1391 37.28 +- 15.91 2 0 0 0 0.10 +- 0.08 2 5

PF01661 (2/2) Macro domain
PF01129 (2/2) NAD:arginine ADP-ribosyltransferase
PF12802 (1/2) MarR family
PF07690 (1/2) Major Facilitator Superfamily
PF06626 (1/2) Protein of unknown function (DUF1152)
jaccard_groups_1424 387.87 +- 406.55 24 0 6 0 0.04 +- 0.13 24 4

PF00717 (24/24) Peptidase S24-like
PF00005 (24/24) ABC transporter
PF07291 (21/24) Methylamine utilisation protein MauE
PF00578 (14/24) AhpC/TSA family
jaccard_groups_1397 470.58 +- 446.89 44 0 14 44 0.03 +- 0.07 44 6

TIGR03882 (44/44) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (44/44) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (44/44) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00005 (44/44) ABC transporter
PF00881 (43/44) Nitroreductase family
PF00664 (41/44) ABC transporter transmembrane region
jaccard_groups_4161 15.72 +- 2.87 3 0 0 0 0.20 +- 0.18 3 5

PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02057 (3/3) Glycosyl hydrolase family 59
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
jaccard_groups_3862 108.92 +- 28.27 4 0 4 0 0.12 +- 0.27 4 19

PF18605 (4/4) Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF14759 (4/4) Reductase C-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF08659 (4/4) KR domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF06368 (4/4) Methylaspartate mutase E chain (MutE)
PF02909 (4/4) Tetracyclin repressor-like, C-terminal domain
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (4/4) B12 binding domain
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
jaccard_groups_3860 480.08 +- 238.08 3 0 0 0 0.07 +- 0.14 3 11

TIGR01426 (3/3) glycosyltransferase, MGT family
PF13546 (3/3) DDE superfamily endonuclease
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (3/3) Pretoxin HINT domain
PF04471 (3/3) Restriction endonuclease
PF03752 (3/3) Short repeats of unknown function
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF00535 (3/3) Glycosyl transferase family 2
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00089 (3/3) Trypsin
PF00082 (3/3) Subtilase family
jaccard_groups_3861 194.17 +- 42.63 5 0 3 0 0.01 +- 0.00 5 5

TIGR02276 (5/5) 40-residue YVTN family beta-propeller repeat
PF16640 (5/5) Bacterial Ig-like domain (group 3)
PF14378 (5/5) PAP2 superfamily
PF09594 (5/5) Glycosyltransferase family 87
PF01833 (5/5) IPT/TIG domain
jaccard_groups_3867 26.80 +- 4.84 4 0 4 0 0.17 +- 0.31 4 10

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF17196 (4/4) Protein of unknown function (DUF5133)
PF13964 (4/4) Kelch motif
PF09118 (4/4) Domain of unknown function (DUF1929)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF00135 (4/4) Carboxylesterase family
PF00005 (4/4) ABC transporter
PF00754 (3/4) F5/8 type C domain
PF13305 (2/4) Tetracyclin repressor-like, C-terminal domain
PF01381 (2/4) Helix-turn-helix
jaccard_groups_3864 335.14 +- 400.91 5 0 0 0 0.09 +- 0.23 5 11

TIGR01525 (5/5) heavy metal translocating P-type ATPase
PF13462 (5/5) Thioredoxin
PF07884 (5/5) Vitamin K epoxide reductase family
PF02683 (5/5) Cytochrome C biogenesis protein transmembrane region
PF01545 (5/5) Cation efflux family
PF01022 (5/5) Bacterial regulatory protein, arsR family
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00578 (5/5) AhpC/TSA family
PF00122 (5/5) E1-E2 ATPase
PF02630 (4/5) SCO1/SenC
TIGR01297 (3/5) cation diffusion facilitator family transporter
jaccard_groups_3865 161.85 +- 22.71 5 0 5 5 0.05 +- 0.09 5 10

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00144 (5/5) Beta-lactamase
PF13472 (4/5) GDSL-like Lipase/Acylhydrolase family
PF06094 (4/5) Gamma-glutamyl cyclotransferase, AIG2-like
PF01113 (4/5) Dihydrodipicolinate reductase, N-terminus
PF00069 (4/5) Protein kinase domain
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
jaccard_groups_4619 111.61 +- 43.19 2 0 1 0 0.05 +- 0.09 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01614 (2/2) Bacterial transcriptional regulator
PF01266 (2/2) FAD dependent oxidoreductase
PF00005 (2/2) ABC transporter
PF01425 (1/2) Amidase
jaccard_groups_297 78.98 +- 87.03 6 0 2 0 0.08 +- 0.13 6 1

PF01522 (6/6) Polysaccharide deacetylase
jaccard_groups_293 145.17 +- 199.57 75 0 7 0 0.08 +- 0.13 75 4

PF07992 (73/75) Pyridine nucleotide-disulphide oxidoreductase
PF14759 (70/75) Reductase C-terminal
PF13370 (62/75) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (58/75) Cytochrome P450
jaccard_groups_292 86.21 +- 90.21 13 0 1 0 0.07 +- 0.08 13 2

PF01979 (13/13) Amidohydrolase family
PF05988 (7/13) Bacterial protein of unknown function (DUF899)
jaccard_groups_4611 26.45 +- 13.54 3 0 0 0 0.14 +- 0.26 3 3

PF13649 (3/3) Methyltransferase domain
PF08962 (3/3) Domain of unknown function (DUF1876)
PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_4346 403.42 +- 302.64 4 0 0 0 0.08 +- 0.20 4 20

TIGR00556 (4/4) phosphopantetheine--protein transferase domain
TIGR00027 (4/4) methyltransferase, TIGR00027 family
PF11583 (4/4) P-aminobenzoate N-oxygenase AurF
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (4/4) Major Facilitator Superfamily
PF04072 (4/4) Leucine carboxyl methyltransferase
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01522 (4/4) Polysaccharide deacetylase
PF01243 (4/4) Pyridoxamine 5'-phosphate oxidase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF17837 (3/4) 4'-phosphopantetheinyl transferase N-terminal domain
PF13560 (3/4) Helix-turn-helix domain
PF12900 (3/4) Pyridoxamine 5'-phosphate oxidase
PF03704 (3/4) Bacterial transcriptional activator domain
PF00931 (3/4) NB-ARC domain
PF00561 (3/4) alpha/beta hydrolase fold
TIGR00678 (2/4) DNA polymerase III, delta' subunit
PF13177 (2/4) DNA polymerase III, delta subunit
jaccard_groups_4345 581.28 +- 100.36 4 0 0 0 0.01 +- 0.01 4 11

PF13023 (4/4) HD domain
PF07690 (4/4) Major Facilitator Superfamily
PF03781 (4/4) Sulfatase-modifying factor enzyme 1
PF00925 (4/4) GTP cyclohydrolase II
PF00400 (4/4) WD domain, G-beta repeat
PF01156 (3/4) Inosine-uridine preferring nucleoside hydrolase
PF00860 (3/4) Permease family
PF00534 (3/4) Glycosyl transferases group 1
TIGR00326 (2/4) riboflavin biosynthesis protein RibD
PF01872 (2/4) RibD C-terminal domain
PF00383 (2/4) Cytidine and deoxycytidylate deaminase zinc-binding region
jaccard_groups_4760 138.79 +- 76.03 3 0 1 0 0.04 +- 0.08 3 3

PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF01596 (3/3) O-methyltransferase
PF01474 (3/3) Class-II DAHP synthetase family
jaccard_groups_2768 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
jaccard_groups_1640 397.87 +- 89.63 2 0 1 0 0.04 +- 0.10 2 16

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (2/2) Beta-lactamase
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (1/2) amino acid adenylation domain
PF03621 (1/2) MbtH-like protein
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01609 (1/2) Transposase DDE domain
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme
jaccard_groups_1641 23.53 +- 5.29 9 0 2 0 0.18 +- 0.31 9 7

PF13560 (9/9) Helix-turn-helix domain
PF09339 (9/9) IclR helix-turn-helix domain
PF04149 (9/9) Domain of unknown function (DUF397)
PF05362 (8/9) Lon protease (S16) C-terminal proteolytic domain
PF04978 (7/9) Protein of unknown function (DUF664)
PF00005 (7/9) ABC transporter
PF00753 (5/9) Metallo-beta-lactamase superfamily
jaccard_groups_1643 89.18 +- 55.27 2 0 2 1 0.04 +- 0.05 2 5

TIGR01317 (2/2) glutamate synthase, NADH/NADPH, small subunit
PF14691 (2/2) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05147 (1/2) Lanthionine synthetase C-like protein
PF00857 (1/2) Isochorismatase family
jaccard_groups_4291 227.25 +- 162.75 2 0 0 0 0.03 +- 0.05 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
jaccard_groups_4293 353.12 +- 118.50 4 0 4 0 0.01 +- 0.01 4 5

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (4/4) Major Facilitator Superfamily
PF00501 (4/4) AMP-binding enzyme
jaccard_groups_4909 481.00 +- 41.72 3 0 0 0 0.02 +- 0.02 3 7

PF07940 (3/3) Heparinase II/III-like protein
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
jaccard_groups_583 36.34 +- 13.06 2 0 0 0 0.16 +- 0.18 2 8

PF17957 (2/2) Bacterial Ig domain
PF02011 (2/2) Glycosyl hydrolase family 48
PF00553 (2/2) Cellulose binding domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00082 (1/2) Subtilase family
jaccard_groups_584 156.00 +- 39.00 2 0 0 0 0.06 +- 0.09 2 10

PF12822 (2/2) ECF transporter, substrate-specific component
PF02361 (2/2) Cobalt transport protein
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00005 (2/2) ABC transporter
TIGR02779 (1/2) DNA ligase D, ligase domain
PF14478 (1/2) Domain of unknown function (DUF4430)
PF04679 (1/2) ATP dependent DNA ligase C terminal region
PF01068 (1/2) ATP dependent DNA ligase domain
PF00590 (1/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00485 (1/2) Phosphoribulokinase / Uridine kinase family
jaccard_groups_3264 99.63 +- 65.64 3 0 3 0 0.15 +- 0.29 3 15

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00975 (3/3) Thioesterase domain
PF00891 (3/3) O-methyltransferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF13822 (2/3) Acyl-CoA carboxylase epsilon subunit
jaccard_groups_3265 53.01 +- 18.72 2 0 2 0 0.14 +- 0.13 2 9

PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF04954 (2/2) Siderophore-interacting protein
PF01497 (2/2) Periplasmic binding protein
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
TIGR03296 (1/2) M6 family metalloprotease domain
PF13828 (1/2) Domain of unknown function (DUF4190)
jaccard_groups_25 64.26 +- 232.27 178 0 73 0 0.14 +- 0.21 178 3

PF05331 (178/178) Protein of unknown function (DUF742)
PF03259 (178/178) Roadblock/LC7 domain
PF03029 (177/178) Conserved hypothetical ATP binding protein
jaccard_groups_4589 687.61 +- 49.40 3 0 0 0 0.02 +- 0.01 3 7

PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF07859 (2/3) alpha/beta hydrolase fold
PF00440 (2/3) Bacterial regulatory proteins, tetR family
PF00155 (2/3) Aminotransferase class I and II
jaccard_groups_27 147.43 +- 45.14 7 0 6 0 0.01 +- 0.00 7 2

PF03972 (7/7) MmgE/PrpD family
PF00781 (6/7) Diacylglycerol kinase catalytic domain
jaccard_groups_26 135.00 +- 160.71 23 0 2 0 0.04 +- 0.06 23 1

PF00293 (23/23) NUDIX domain
jaccard_groups_21 132.05 +- 198.09 28 0 1 0 0.08 +- 0.16 28 3

TIGR03696 (28/28) RHS repeat-associated core domain
TIGR01643 (27/28) YD repeat (two copies)
PF05593 (27/28) RHS Repeat
jaccard_groups_20 12.27 +- 1.66 2 0 0 0 0.17 +- 0.23 2 4

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF07883 (2/2) Cupin domain
PF01609 (2/2) Transposase DDE domain
PF00561 (2/2) alpha/beta hydrolase fold
jaccard_groups_23 116.03 +- 127.58 70 0 10 0 0.09 +- 0.16 70 3

PF02771 (70/70) Acyl-CoA dehydrogenase, N-terminal domain
PF00441 (69/70) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (62/70) Acyl-CoA dehydrogenase, middle domain
jaccard_groups_22 77.08 +- 84.34 4 0 0 0 0.12 +- 0.16 4 3

PF12802 (4/4) MarR family
PF01965 (2/4) DJ-1/PfpI family
PF00069 (2/4) Protein kinase domain
jaccard_groups_4580 61.64 +- 8.63 2 0 0 0 0.06 +- 0.06 2 7

PF13396 (2/2) Phospholipase_D-nuclease N-terminal
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF07690 (1/2) Major Facilitator Superfamily
PF03729 (1/2) Short repeat of unknown function (DUF308)
PF03631 (1/2) Virulence factor BrkB
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF00857 (1/2) Isochorismatase family
jaccard_groups_4582 1036.00 +- 4.00 2 0 0 0 0.01 +- 0.00 2 8

PF13411 (2/2) MerR HTH family regulatory protein
PF07730 (2/2) Histidine kinase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01040 (2/2) UbiA prenyltransferase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
jaccard_groups_29 84.93 +- 89.39 76 0 14 12 0.07 +- 0.13 76 1

PF00583 (76/76) Acetyltransferase (GNAT) family
jaccard_groups_28 35.35 +- 50.26 9 0 0 0 0.16 +- 0.17 9 3

PF07883 (9/9) Cupin domain
PF01381 (9/9) Helix-turn-helix
PF13649 (6/9) Methyltransferase domain
jaccard_groups_349 44.45 +- 81.07 16 0 2 0 0.15 +- 0.14 16 2

PF03067 (16/16) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (13/16) SPFH domain / Band 7 family
jaccard_groups_348 150.88 +- 148.06 5 0 1 0 0.06 +- 0.11 5 1

PF03992 (5/5) Antibiotic biosynthesis monooxygenase
jaccard_groups_2393 405.45 +- 194.73 13 0 0 0 0.04 +- 0.04 13 6

PF13531 (13/13) Bacterial extracellular solute-binding protein
PF08402 (13/13) TOBE domain
PF00528 (13/13) Binding-protein-dependent transport system inner membrane component
PF00005 (13/13) ABC transporter
PF00694 (10/13) Aconitase C-terminal domain
PF00106 (7/13) short chain dehydrogenase
jaccard_groups_340 104.85 +- 104.09 13 0 2 0 0.06 +- 0.10 13 1

PF13673 (13/13) Acetyltransferase (GNAT) domain
jaccard_groups_347 17.17 +- 11.44 4 0 1 0 0.16 +- 0.13 4 2

PF04264 (4/4) YceI-like domain
PF13620 (2/4) Carboxypeptidase regulatory-like domain
jaccard_groups_4833 134.45 +- 23.20 3 0 3 0 0.08 +- 0.11 3 12

TIGR04498 (3/3) abortive infection protein, AbiV family
PF18728 (3/3) AbiV
PF03711 (3/3) Orn/Lys/Arg decarboxylase, C-terminal domain
PF03709 (3/3) Orn/Lys/Arg decarboxylase, N-terminal domain
PF02371 (3/3) Transposase IS116/IS110/IS902 family
PF01609 (3/3) Transposase DDE domain
PF01548 (3/3) Transposase
PF01276 (3/3) Orn/Lys/Arg decarboxylase, major domain
PF00494 (3/3) Squalene/phytoene synthase
PF00348 (3/3) Polyprenyl synthetase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
jaccard_groups_4834 55.58 +- 31.77 3 0 0 0 0.09 +- 0.08 3 9

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF02734 (3/3) DAK2 domain
PF02733 (3/3) Dak1 domain
PF02502 (3/3) Ribose/Galactose Isomerase
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
TIGR00689 (2/3) sugar-phosphate isomerase, RpiB/LacA/LacB family
jaccard_groups_3399 689.70 +- 296.39 7 0 2 2 0.02 +- 0.02 7 15

PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF13535 (7/7) ATP-grasp domain
PF13434 (7/7) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (7/7) tRNA synthetases class I (M)
PF08031 (7/7) Berberine and berberine like
PF07883 (7/7) Cupin domain
PF01565 (7/7) FAD binding domain
PF01266 (7/7) FAD dependent oxidoreductase
PF08028 (6/7) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (6/7) Major Facilitator Superfamily
PF02771 (6/7) Acyl-CoA dehydrogenase, N-terminal domain
PF13714 (5/7) Phosphoenolpyruvate phosphomutase
PF02274 (5/7) Amidinotransferase
PF18130 (4/7) ATP-grasp N-terminal domain
PF01613 (4/7) Flavin reductase like domain
jaccard_groups_4836 205.73 +- 75.73 2 0 0 0 0.02 +- 0.02 2 8

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00800 (2/2) Prephenate dehydratase
PF00296 (2/2) Luciferase-like monooxygenase
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF02467 (1/2) Transcription factor WhiB
PF00702 (1/2) haloacid dehalogenase-like hydrolase
jaccard_groups_4837 117.38 +- 3.56 2 0 0 0 0.03 +- 0.02 2 7

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13545 (2/2) Crp-like helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF00702 (1/2) haloacid dehalogenase-like hydrolase
jaccard_groups_4839 14.15 +- 8.70 3 0 0 0 0.19 +- 0.17 3 4

PF14019 (3/3) Protein of unknown function (DUF4235)
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01814 (3/3) Hemerythrin HHE cation binding domain
jaccard_groups_3396 77.17 +- 63.39 7 0 7 0 0.07 +- 0.13 7 8

TIGR00747 (7/7) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13521 (7/7) AAA domain
PF12680 (7/7) SnoaL-like domain
PF11468 (7/7) Aromatic prenyltransferase Orf2
PF08545 (7/7) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (7/7) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05655 (7/7) Pseudomonas avirulence D protein (AvrD)
PF03358 (6/7) NADPH-dependent FMN reductase
jaccard_groups_3391 2397.31 +- 3302.74 7 0 4 7 0.03 +- 0.05 7 18

TIGR03945 (7/7) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (7/7) 2,3-diaminopropionate biosynthesis protein SbnB
PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF07977 (7/7) FabA-like domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01571 (7/7) Aminomethyltransferase folate-binding domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
PF00698 (6/7) Acyl transferase domain
PF00501 (6/7) AMP-binding enzyme
PF00155 (6/7) Aminotransferase class I and II
PF00005 (6/7) ABC transporter
PF04738 (5/7) Lantibiotic dehydratase, N terminus
PF00583 (5/7) Acetyltransferase (GNAT) family
PF07690 (4/7) Major Facilitator Superfamily
PF01061 (4/7) ABC-2 type transporter
jaccard_groups_6296 1834.98 +- 1519.02 2 0 0 0 0.02 +- 0.02 2 14

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (2/2) SnoaL-like domain
PF09339 (2/2) IclR helix-turn-helix domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF01614 (2/2) Bacterial transcriptional regulator
PF01613 (2/2) Flavin reductase like domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
jaccard_groups_6294 68.31 +- 1.00 2 0 0 0 0.09 +- 0.20 2 13

TIGR03885 (2/2) probable non-F420 flavinoid oxidoreductase
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16657 (2/2) Maltogenic Amylase, C-terminal domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF13384 (2/2) Homeodomain-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF05231 (2/2) MASE1
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF00296 (2/2) Luciferase-like monooxygenase
PF00128 (2/2) Alpha amylase, catalytic domain
jaccard_groups_6295 1556.00 +- 524.00 2 0 0 0 0.01 +- 0.00 2 12

PF11533 (2/2) Protein of unknown function (DUF3225)
PF07969 (2/2) Amidohydrolase family
PF07883 (2/2) Cupin domain
PF03069 (2/2) Acetamidase/Formamidase family
PF02633 (2/2) Creatinine amidohydrolase
PF01613 (2/2) Flavin reductase like domain
PF01565 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00857 (2/2) Isochorismatase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
jaccard_groups_6292 453.00 +- 63.00 2 0 0 0 0.01 +- 0.00 2 5

PF13452 (2/2) N-terminal half of MaoC dehydratase
PF03061 (2/2) Thioesterase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
PF07681 (1/2) DoxX
jaccard_groups_3009 298.71 +- 207.75 5 0 0 5 0.03 +- 0.03 5 17

TIGR04050 (5/5) AIR synthase-related protein, MSMEG_0567 C-terminal family
TIGR04047 (5/5) glycosyltransferase, MSMEG_0565 family
TIGR04046 (5/5) flavin-dependent oxidoreductase, MSMEG_0569 family
TIGR04045 (5/5) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family
TIGR04044 (5/5) MSMEG_0572 family protein
TIGR04043 (5/5) radical SAM protein, MSMEG_0568 family
PF13738 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF13439 (5/5) Glycosyltransferase Family 4
PF04909 (5/5) Amidohydrolase
PF04055 (5/5) Radical SAM superfamily
PF02769 (5/5) AIR synthase related protein, C-terminal domain
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00586 (5/5) AIR synthase related protein, N-terminal domain
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00534 (5/5) Glycosyl transferases group 1
TIGR04042 (4/5) MSMEG_0570 family protein
PF02635 (4/5) DsrE/DsrF-like family
jaccard_groups_6290 128.17 +- 9.48 2 0 0 0 0.02 +- 0.02 2 6

PF05962 (2/2) HutD
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01593 (2/2) Flavin containing amine oxidoreductase
PF13516 (1/2) Leucine Rich repeat
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF03583 (1/2) Secretory lipase
jaccard_groups_6495 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
jaccard_groups_3004 622.57 +- 496.74 6 0 0 0 0.07 +- 0.20 6 13

TIGR01122 (6/6) branched-chain amino acid aminotransferase
PF13378 (6/6) Enolase C-terminal domain-like
PF11583 (6/6) P-aminobenzoate N-oxygenase AurF
PF07690 (6/6) Major Facilitator Superfamily
PF04339 (6/6) Peptidogalycan biosysnthesis/recognition
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (6/6) Malate/L-lactate dehydrogenase
PF01063 (6/6) Amino-transferase class IV
PF18603 (5/6) L-amino acid ligase C-terminal domain 2
PF13535 (5/6) ATP-grasp domain
PF02222 (5/6) ATP-grasp domain
PF01070 (5/6) FMN-dependent dehydrogenase
jaccard_groups_4315 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
jaccard_groups_3006 142.43 +- 60.05 5 0 2 0 0.04 +- 0.01 5 9

TIGR01060 (5/5) phosphopyruvate hydratase
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF03952 (5/5) Enolase, N-terminal domain
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00113 (5/5) Enolase, C-terminal TIM barrel domain
PF00107 (5/5) Zinc-binding dehydrogenase
PF02737 (4/5) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (4/5) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_4642 86.99 +- 43.01 2 0 0 0 0.05 +- 0.08 2 5

PF14078 (2/2) Domain of unknown function (DUF4259)
PF13649 (2/2) Methyltransferase domain
PF03780 (2/2) Asp23 family, cell envelope-related function
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF06902 (1/2) Divergent 4Fe-4S mono-cluster
jaccard_groups_3468 313.68 +- 254.93 3 0 0 0 0.04 +- 0.15 3 8

PF17042 (3/3) Nucleotide-binding C-terminal domain
PF13531 (3/3) Bacterial extracellular solute-binding protein
PF12697 (3/3) Alpha/beta hydrolase family
PF07005 (3/3) Sugar-binding N-terminal domain
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF14588 (2/3) YjgF/chorismate_mutase-like, putative endoribonuclease
PF14336 (2/3) Domain of unknown function (DUF4392)
jaccard_groups_3469 52.26 +- 36.23 3 0 2 0 0.11 +- 0.25 3 5

TIGR01444 (3/3) methyltransferase, FkbM family
PF13439 (3/3) Glycosyltransferase Family 4
PF09594 (3/3) Glycosyltransferase family 87
PF05050 (3/3) Methyltransferase FkbM domain
PF00534 (3/3) Glycosyl transferases group 1
jaccard_groups_3465 148.75 +- 10.28 2 0 0 2 0.08 +- 0.11 2 22

PF13537 (2/2) Glutamine amidotransferase domain
PF12242 (2/2) NAD(P)H binding domain of trans-2-enoyl-CoA reductase
PF12241 (2/2) Trans-2-enoyl-CoA reductase catalytic region
PF07730 (2/2) Histidine kinase
PF07055 (2/2) Enoyl reductase FAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
PF00733 (2/2) Asparagine synthase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00135 (2/2) Carboxylesterase family
PF00072 (2/2) Response regulator receiver domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13354 (1/2) Beta-lactamase enzyme family
PF12867 (1/2) DinB superfamily
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF09490 (1/2) Probable cobalt transporter subunit (CbtA)
PF09489 (1/2) Probable cobalt transporter subunit (CbtB)
PF07690 (1/2) Major Facilitator Superfamily
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_758 9.87 +- 0.59 2 0 0 0 0.20 +- 0.28 2 2

PF02156 (2/2) Glycosyl hydrolase family 26
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_6189 1297.58 +- 1172.42 2 0 2 0 0.08 +- 0.23 2 17

TIGR01746 (2/2) thioester reductase domain
PF17920 (2/2) Tetracyclin repressor-like, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF08031 (2/2) Berberine and berberine like
PF07993 (2/2) Male sterility protein
PF04820 (2/2) Tryptophan halogenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01061 (2/2) ABC-2 type transporter
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_3489 234.12 +- 123.22 6 0 0 0 0.04 +- 0.05 6 5

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (6/6) Major Facilitator Superfamily
PF01553 (6/6) Acyltransferase
PF01148 (6/6) Cytidylyltransferase family
PF01066 (6/6) CDP-alcohol phosphatidyltransferase
jaccard_groups_6180 668.05 +- 342.08 2 0 2 0 0.04 +- 0.15 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13579 (2/2) Glycosyl transferase 4-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01063 (2/2) Amino-transferase class IV
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00464 (2/2) Serine hydroxymethyltransferase
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF00005 (2/2) ABC transporter
PF13649 (1/2) Methyltransferase domain
PF13489 (1/2) Methyltransferase domain
PF13276 (1/2) HTH-like domain
PF12848 (1/2) ABC transporter
PF12833 (1/2) Helix-turn-helix domain
PF05014 (1/2) Nucleoside 2-deoxyribosyltransferase
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain
jaccard_groups_6181 929.22 +- 318.78 2 0 0 0 0.01 +- 0.03 2 10

PF14307 (2/2) Glycosyltransferase WbsX
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01061 (2/2) ABC-2 type transporter
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
jaccard_groups_6186 296.14 +- 147.30 2 0 2 0 0.02 +- 0.04 2 10

TIGR00034 (2/2) 3-deoxy-7-phosphoheptulonate synthase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF00793 (2/2) DAHP synthetase I family
PF00550 (2/2) Phosphopantetheine attachment site
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00221 (2/2) Aromatic amino acid lyase
PF00171 (2/2) Aldehyde dehydrogenase family
PF18678 (1/2) Allene oxide cyclase barrel like domain
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
jaccard_groups_6187 87.00 +- 33.00 2 0 1 0 0.11 +- 0.12 2 14

PF13183 (2/2) 4Fe-4S dicluster domain
PF07063 (2/2) Domain of unknown function (DUF1338)
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF04471 (2/2) Restriction endonuclease
PF04191 (2/2) Phospholipid methyltransferase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02754 (2/2) Cysteine-rich domain
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01968 (2/2) Hydantoinase/oxoprolinase
PF01565 (2/2) FAD binding domain
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
jaccard_groups_3647 510.56 +- 143.94 5 0 1 0 0.05 +- 0.18 5 6

PF17914 (5/5) HopA1 effector protein family
PF02441 (5/5) Flavoprotein
PF01636 (5/5) Phosphotransferase enzyme family
PF02897 (4/5) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (4/5) Prolyl oligopeptidase family
PF00296 (4/5) Luciferase-like monooxygenase
jaccard_groups_3644 58.50 +- 52.57 5 0 1 0 0.11 +- 0.10 5 8

PF12697 (5/5) Alpha/beta hydrolase family
PF02036 (5/5) SCP-2 sterol transfer family
PF00175 (5/5) Oxidoreductase NAD-binding domain
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (5/5) short chain dehydrogenase
PF00037 (5/5) 4Fe-4S binding domain
PF07045 (4/5) Domain of unknown function (DUF1330)
PF00970 (3/5) Oxidoreductase FAD-binding domain
jaccard_groups_2738 352.65 +- 184.15 11 0 2 0 0.03 +- 0.03 11 12

PF12833 (11/11) Helix-turn-helix domain
PF12625 (11/11) Arabinose-binding domain of AraC transcription regulator, N-term
PF08240 (11/11) Alcohol dehydrogenase GroES-like domain
PF07690 (11/11) Major Facilitator Superfamily
PF06821 (11/11) Serine hydrolase
PF05853 (11/11) beta-keto acid cleavage enzyme
PF02668 (11/11) Taurine catabolism dioxygenase TauD, TfdA family
PF00107 (11/11) Zinc-binding dehydrogenase
TIGR01217 (7/11) acetoacetate-CoA ligase
PF16177 (7/11) Acetyl-coenzyme A synthetase N-terminus
PF13193 (7/11) AMP-binding enzyme C-terminal domain
PF00501 (7/11) AMP-binding enzyme
jaccard_groups_3640 952.16 +- 734.28 6 0 0 0 0.04 +- 0.14 6 13

TIGR01726 (6/6) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF17853 (6/6) GGDEF-like domain
PF13556 (6/6) PucR C-terminal helix-turn-helix domain
PF07978 (6/6) NIPSNAP
PF07969 (6/6) Amidohydrolase family
PF02627 (6/6) Carboxymuconolactone decarboxylase family
PF01613 (6/6) Flavin reductase like domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00497 (6/6) Bacterial extracellular solute-binding proteins, family 3
PF00296 (6/6) Luciferase-like monooxygenase
PF00264 (6/6) Common central domain of tyrosinase
PF00171 (6/6) Aldehyde dehydrogenase family
PF00005 (6/6) ABC transporter
jaccard_groups_6472 356.75 +- 163.25 2 0 0 0 0.02 +- 0.00 2 6

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01321 (2/2) Creatinase/Prolidase N-terminal domain
PF00557 (2/2) Metallopeptidase family M24
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF03358 (1/2) NADPH-dependent FMN reductase
jaccard_groups_2734 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_6470 730.56 +- 559.44 2 0 1 0 0.07 +- 0.16 2 16

TIGR04458 (2/2) 4-nitrotryptophan synthase
TIGR00730 (2/2) TIGR00730 family protein
PF13649 (2/2) Methyltransferase domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF02898 (2/2) Nitric oxide synthase, oxygenase domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01745 (2/2) Isopentenyl transferase
PF01565 (2/2) FAD binding domain
PF00872 (2/2) Transposase, Mutator family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_6471 545.32 +- 29.32 2 0 0 0 0.01 +- 0.00 2 9

PF04199 (2/2) Putative cyclase
PF02728 (2/2) Copper amine oxidase, N3 domain
PF01179 (2/2) Copper amine oxidase, enzyme domain
PF01019 (2/2) Gamma-glutamyltranspeptidase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
jaccard_groups_6475 669.63 +- 206.66 2 0 0 0 0.03 +- 0.02 2 18

PF13407 (2/2) Periplasmic binding protein domain
PF10370 (2/2) Domain of unknown function (DUF2437)
PF03928 (2/2) Haem-degrading
PF03466 (2/2) LysR substrate binding domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00171 (2/2) Aldehyde dehydrogenase family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (2/2) ABC transporter
PF09981 (1/2) Uncharacterized protein conserved in bacteria (DUF2218)
PF04909 (1/2) Amidohydrolase
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02615 (1/2) Malate/L-lactate dehydrogenase
PF01266 (1/2) FAD dependent oxidoreductase
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_6054 298.86 +- 7.02 2 0 0 0 0.03 +- 0.01 2 15

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02353 (2/2) Mycolic acid cyclopropane synthetase
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_6052 851.56 +- 379.61 2 0 2 2 0.02 +- 0.03 2 45

TIGR04098 (2/2) biosynthesis cluster domain
TIGR02814 (2/2) PfaD family protein
TIGR01733 (2/2) amino acid adenylation domain
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF18238 (2/2) LnmK N-terminal Hot Dog Fold domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08659 (2/2) KR domain
PF08540 (2/2) Hydroxymethylglutaryl-coenzyme A synthase C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01212 (2/2) Beta-eliminating lyase
PF01154 (2/2) Hydroxymethylglutaryl-coenzyme A synthase N terminal
PF00975 (2/2) Thioesterase domain
PF00881 (2/2) Nitroreductase family
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
TIGR02124 (1/2) hydrogenase expression/formation protein HypE
TIGR01762 (1/2) chlorinating enzyme
TIGR00143 (1/2) carbamoyltransferase HypF
PF17788 (1/2) HypF Kae1-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13545 (1/2) Crp-like helix-turn-helix domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12680 (1/2) SnoaL-like domain
PF11528 (1/2) Protein of unknown function (DUF3224)
PF08242 (1/2) Methyltransferase domain
PF07722 (1/2) Peptidase C26
PF07503 (1/2) HypF finger
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03795 (1/2) YCII-related domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF01300 (1/2) Telomere recombination
PF00857 (1/2) Isochorismatase family
PF00708 (1/2) Acylphosphatase
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00464 (1/2) Serine hydroxymethyltransferase
PF00027 (1/2) Cyclic nucleotide-binding domain
jaccard_groups_2023 49.08 +- 19.83 5 0 0 0 0.24 +- 0.31 5 12

PF12704 (5/5) MacB-like periplasmic core domain
PF07730 (5/5) Histidine kinase
PF02687 (5/5) FtsX-like permease family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
PF00005 (5/5) ABC transporter
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF18029 (4/5) Glyoxalase-like domain
PF12697 (4/5) Alpha/beta hydrolase family
PF08281 (4/5) Sigma-70, region 4
PF07992 (4/5) Pyridine nucleotide-disulphide oxidoreductase
PF04542 (4/5) Sigma-70 region 2
jaccard_groups_6059 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
jaccard_groups_3733 209.47 +- 78.48 3 0 0 0 0.03 +- 0.05 3 6

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
PF14833 (2/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF03446 (2/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_5558 56.73 +- 9.21 2 0 0 0 0.09 +- 0.12 2 7

PF18029 (2/2) Glyoxalase-like domain
PF12867 (2/2) DinB superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
jaccard_groups_5559 127.29 +- 23.67 2 0 2 0 0.04 +- 0.06 2 8

PF13564 (2/2) DoxX-like family
PF12680 (2/2) SnoaL-like domain
PF08843 (2/2) Nucleotidyl transferase AbiEii toxin, Type IV TA system
PF06441 (2/2) Epoxide hydrolase N terminus
PF03413 (2/2) Peptidase propeptide and YPEB domain
PF01810 (2/2) LysE type translocator
PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
jaccard_groups_2357 146.86 +- 84.45 15 0 7 0 0.07 +- 0.19 15 11

PF18603 (15/15) L-amino acid ligase C-terminal domain 2
PF18130 (15/15) ATP-grasp N-terminal domain
PF13535 (15/15) ATP-grasp domain
PF13434 (15/15) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (15/15) tRNA synthetases class I (M)
PF07883 (15/15) Cupin domain
PF01266 (15/15) FAD dependent oxidoreductase
PF07690 (13/15) Major Facilitator Superfamily
PF02274 (12/15) Amidinotransferase
PF00496 (12/15) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00999 (11/15) Sodium/hydrogen exchanger family
jaccard_groups_2356 172.97 +- 64.75 12 0 0 0 0.06 +- 0.04 12 7

PF10633 (12/12) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (12/12) Alpha mannosidase middle domain
PF01418 (12/12) Helix-turn-helix domain, rpiR family
PF01380 (12/12) SIS domain
PF01074 (12/12) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (12/12) Binding-protein-dependent transport system inner membrane component
PF01547 (7/12) Bacterial extracellular solute-binding protein
jaccard_groups_2606 99.38 +- 16.84 2 0 0 0 0.10 +- 0.24 2 24

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR02009 (2/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (2/2) Glyoxalase-like domain
PF17866 (2/2) AAA lid domain
PF14436 (2/2) Bacterial EndoU nuclease
PF13560 (2/2) Helix-turn-helix domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF13229 (2/2) Right handed beta helix region
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (2/2) Cupin domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03636 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
jaccard_groups_5882 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
jaccard_groups_2608 1208.37 +- 831.06 7 0 7 0 0.02 +- 0.05 7 19

TIGR01686 (7/7) FkbH domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF02771 (7/7) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (7/7) Acyl-CoA dehydrogenase, middle domain
PF02737 (7/7) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (7/7) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (7/7) Acyl transferase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00441 (7/7) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
PF13561 (6/7) Enoyl-(Acyl carrier protein) reductase
TIGR01733 (4/7) amino acid adenylation domain
PF18130 (4/7) ATP-grasp N-terminal domain
PF16197 (4/7) Ketoacyl-synthetase C-terminal extension
PF13649 (4/7) Methyltransferase domain
PF13535 (4/7) ATP-grasp domain
PF13193 (4/7) AMP-binding enzyme C-terminal domain
PF07690 (4/7) Major Facilitator Superfamily
PF00501 (4/7) AMP-binding enzyme
jaccard_groups_2358 61.38 +- 39.40 14 0 6 0 0.12 +- 0.25 14 13

PF13977 (14/14) BetI-type transcriptional repressor, C-terminal
PF13607 (14/14) Succinyl-CoA ligase like flavodoxin domain
PF13549 (14/14) ATP-grasp domain
PF13459 (14/14) 4Fe-4S single cluster domain
PF13380 (14/14) CoA binding domain
PF02771 (14/14) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (14/14) Acyl-CoA dehydrogenase, middle domain
PF02737 (14/14) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (14/14) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (14/14) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (14/14) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (14/14) Bacterial regulatory proteins, tetR family
PF10589 (13/14) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
jaccard_groups_5886 67.31 +- 39.05 2 0 0 0 0.12 +- 0.27 2 8

PF18841 (2/2) Beta solenoid repeat from Dextranase
PF18783 (2/2) Isopullulanase beta-solenoid repeat
PF17433 (2/2) Glycosyl hydrolase family 49 N-terminal Ig-like domain
PF07681 (2/2) DoxX
PF03718 (2/2) Glycosyl hydrolase family 49
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (1/2) ABC transporter
jaccard_groups_5557 379.29 +- 20.56 2 0 0 0 0.04 +- 0.09 2 15

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF14657 (2/2) Arm DNA-binding domain
PF13612 (2/2) Transposase DDE domain
PF13520 (2/2) Amino acid permease
PF13424 (2/2) Tetratricopeptide repeat
PF01636 (2/2) Phosphotransferase enzyme family
PF01381 (2/2) Helix-turn-helix
PF01225 (2/2) Mur ligase family, catalytic domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00589 (2/2) Phage integrase family
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00005 (2/2) ABC transporter
jaccard_groups_2230 43.95 +- 31.29 5 0 0 0 0.10 +- 0.12 5 2

PF00583 (5/5) Acetyltransferase (GNAT) family
PF07690 (4/5) Major Facilitator Superfamily
jaccard_groups_5427 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 5

PF12261 (2/2) Thermostable hemolysin
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
jaccard_groups_2289 179.35 +- 111.39 8 0 0 8 0.05 +- 0.05 8 8

PF13714 (8/8) Phosphoenolpyruvate phosphomutase
PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF00881 (8/8) Nitroreductase family
TIGR00778 (7/8) alkylhydroperoxidase AhpD family core domain
PF04237 (7/8) YjbR
PF02627 (7/8) Carboxymuconolactone decarboxylase family
PF00107 (7/8) Zinc-binding dehydrogenase
PF01370 (5/8) NAD dependent epimerase/dehydratase family
jaccard_groups_5422 540.00 +- 110.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
PF13649 (2/2) Methyltransferase domain
PF01380 (2/2) SIS domain
PF01263 (2/2) Aldose 1-epimerase
PF00550 (2/2) Phosphopantetheine attachment site
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
jaccard_groups_2281 52.26 +- 21.45 2 0 1 0 0.10 +- 0.18 2 7

TIGR00715 (2/2) precorrin-6x reductase
PF02571 (2/2) Precorrin-6x reductase CbiJ/CobK
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01965 (1/2) DJ-1/PfpI family
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01370 (1/2) NAD dependent epimerase/dehydratase family
jaccard_groups_2283 17.13 +- 2.55 3 0 0 0 0.21 +- 0.21 3 10

TIGR01382 (3/3) intracellular protease, PfpI family
PF18011 (3/3) C-terminal domain found in long catalases
PF11387 (3/3) Protein of unknown function (DUF2795)
PF06628 (3/3) Catalase-related immune-responsive
PF01965 (3/3) DJ-1/PfpI family
PF00571 (3/3) CBS domain
PF00199 (3/3) Catalase
PF02776 (2/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/3) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_5954 212.25 +- 174.75 2 0 0 0 0.05 +- 0.08 2 9

TIGR01995 (2/2) PTS system, beta-glucoside-specific IIABC component
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00232 (2/2) Glycosyl hydrolase family 1
PF13751 (1/2) Transposase DDE domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
jaccard_groups_5950 238.88 +- 175.64 2 0 0 0 0.13 +- 0.27 2 21

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF08241 (2/2) Methyltransferase domain
PF07811 (2/2) TadE-like protein
PF01638 (2/2) HxlR-like helix-turn-helix
PF01580 (2/2) FtsK/SpoIIIE family
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03696 (1/2) RHS repeat-associated core domain
PF15575 (1/2) Immunity protein 49
PF13614 (1/2) AAA domain
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF10609 (1/2) NUBPL iron-transfer P-loop NTPase
PF03534 (1/2) Salmonella virulence plasmid 65kDa B protein
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_5951 758.33 +- 411.67 2 0 0 2 0.03 +- 0.08 2 10

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08007 (2/2) Cupin superfamily protein
PF06182 (2/2) ABC-2 family transporter protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02373 (2/2) JmjC domain, hydroxylase
PF00491 (2/2) Arginase family
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
PF18029 (1/2) Glyoxalase-like domain
jaccard_groups_620 30.20 +- 10.50 2 0 0 0 0.18 +- 0.18 2 9

TIGR00418 (2/2) threonine--tRNA ligase
PF03129 (2/2) Anticodon binding domain
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF13560 (1/2) Helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF04149 (1/2) Domain of unknown function (DUF397)
PF01156 (1/2) Inosine-uridine preferring nucleoside hydrolase
PF00857 (1/2) Isochorismatase family
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_5959 134.11 +- 4.11 2 0 0 0 0.06 +- 0.09 2 15

TIGR03356 (2/2) beta-galactosidase
PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF02055 (2/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01590 (2/2) GAF domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00232 (2/2) Glycosyl hydrolase family 1
jaccard_groups_623 10.74 +- 2.14 2 0 0 0 0.17 +- 0.29 2 11

PF17912 (2/2) MalK OB fold domain
PF00005 (2/2) ABC transporter
TIGR01764 (1/2) DNA binding domain, excisionase family
TIGR00254 (1/2) diguanylate cyclase (GGDEF) domain
PF12728 (1/2) Helix-turn-helix domain
PF12323 (1/2) Helix-turn-helix domain
PF08402 (1/2) TOBE domain
PF03459 (1/2) TOBE domain
PF01266 (1/2) FAD dependent oxidoreductase
PF00990 (1/2) Diguanylate cyclase, GGDEF domain
PF00589 (1/2) Phage integrase family
jaccard_groups_2515 291.36 +- 256.54 8 0 1 0 0.05 +- 0.20 8 7

PF13462 (8/8) Thioredoxin
PF11292 (8/8) Protein of unknown function (DUF3093)
PF09678 (8/8) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF05425 (8/8) Copper resistance protein D
PF04234 (8/8) CopC domain
PF00484 (7/8) Carbonic anhydrase
PF07987 (6/8) Domain of unkown function (DUF1775)
jaccard_groups_2514 42.67 +- 28.48 3 0 2 0 0.13 +- 0.20 3 5

TIGR00026 (3/3) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (3/3) F420H(2)-dependent quinone reductase
PF02525 (3/3) Flavodoxin-like fold
PF00248 (3/3) Aldo/keto reductase family
PF00106 (3/3) short chain dehydrogenase
jaccard_groups_2516 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat
jaccard_groups_5235 311.86 +- 235.41 2 0 0 0 0.03 +- 0.06 2 12

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
TIGR00035 (2/2) aspartate racemase
PF12848 (2/2) ABC transporter
PF09587 (2/2) Bacterial capsule synthesis protein PGA_cap
PF01177 (2/2) Asp/Glu/Hydantoin racemase
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13632 (1/2) Glycosyl transferase family group 2
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF02156 (1/2) Glycosyl hydrolase family 26
PF01522 (1/2) Polysaccharide deacetylase
PF00535 (1/2) Glycosyl transferase family 2
jaccard_groups_5392 60.87 +- 38.37 2 0 0 0 0.08 +- 0.21 2 12

TIGR00254 (2/2) diguanylate cyclase (GGDEF) domain
TIGR00229 (2/2) PAS domain S-box protein
PF17203 (2/2) Single cache domain 3
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13188 (2/2) PAS domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05977 (2/2) Transmembrane secretion effector
PF01590 (2/2) GAF domain
PF00990 (2/2) Diguanylate cyclase, GGDEF domain
PF00563 (2/2) EAL domain
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_933 199.48 +- 208.97 5 0 0 0 0.05 +- 0.11 5 3

TIGR00157 (5/5) ribosome small subunit-dependent GTPase A
PF03193 (5/5) RsgA GTPase
PF13649 (3/5) Methyltransferase domain
jaccard_groups_934 188.55 +- 141.78 3 0 0 0 0.05 +- 0.05 3 3

PF07786 (3/3) Protein of unknown function (DUF1624)
PF04235 (3/3) Protein of unknown function (DUF418)
PF03773 (2/3) Predicted permease
jaccard_groups_4865 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
jaccard_groups_5373 133.61 +- 63.96 2 0 2 0 0.09 +- 0.20 2 22

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16864 (2/2) Dimerisation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF04389 (2/2) Peptidase family M28
PF03621 (2/2) MbtH-like protein
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13847 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00067 (1/2) Cytochrome P450
jaccard_groups_5378 62.04 +- 7.30 2 0 0 0 0.07 +- 0.07 2 4

PF13411 (2/2) MerR HTH family regulatory protein
PF01425 (2/2) Amidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00069 (2/2) Protein kinase domain
jaccard_groups_5176 583.00 +- 67.00 2 0 1 0 0.01 +- 0.00 2 5

PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/2) CoA-transferase family III
PF00067 (1/2) Cytochrome P450
jaccard_groups_5175 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
jaccard_groups_5172 635.23 +- 404.77 2 0 2 0 0.07 +- 0.16 2 26

TIGR01686 (2/2) FkbH domain
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01575 (2/2) MaoC like domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR02814 (1/2) PfaD family protein
PF13613 (1/2) Helix-turn-helix of DDE superfamily endonuclease
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF13191 (1/2) AAA ATPase domain
PF12679 (1/2) ABC-2 family transporter protein
PF08242 (1/2) Methyltransferase domain
PF03060 (1/2) Nitronate monooxygenase
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01609 (1/2) Transposase DDE domain
PF00975 (1/2) Thioesterase domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
jaccard_groups_5173 173.91 +- 183.47 3 0 0 0 0.05 +- 0.06 3 5

PF00891 (3/3) O-methyltransferase domain
PF00351 (3/3) Biopterin-dependent aromatic amino acid hydroxylase
PF00005 (3/3) ABC transporter
PF02945 (2/3) Recombination endonuclease VII
PF00950 (2/3) ABC 3 transport family
jaccard_groups_5171 483.98 +- 296.02 2 0 0 0 0.05 +- 0.18 2 22

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07883 (2/2) Cupin domain
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01613 (2/2) Flavin reductase like domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01042 (2/2) Endoribonuclease L-PSP
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00171 (2/2) Aldehyde dehydrogenase family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR02286 (1/2) phenylacetic acid degradation protein PaaD
TIGR02155 (1/2) phenylacetate-CoA ligase
PF14535 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF03061 (1/2) Thioesterase superfamily
PF01047 (1/2) MarR family
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_804 29.16 +- 20.89 7 0 0 0 0.20 +- 0.32 7 4

TIGR04037 (7/7) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (7/7) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF03358 (7/7) NADPH-dependent FMN reductase
PF00296 (7/7) Luciferase-like monooxygenase
jaccard_groups_5081 15.79 +- 2.01 3 0 0 0 0.19 +- 0.22 3 3

PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00348 (3/3) Polyprenyl synthetase
jaccard_groups_800 105.27 +- 68.80 10 0 4 0 0.04 +- 0.07 10 4

PF14759 (10/10) Reductase C-terminal
PF07992 (10/10) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (10/10) Rieske [2Fe-2S] domain
PF14518 (6/10) Iron-containing redox enzyme
jaccard_groups_802 65.23 +- 34.51 8 0 2 0 0.06 +- 0.06 8 6

TIGR00641 (8/8) methylmalonyl-CoA mutase N-terminal domain
PF03308 (8/8) Methylmalonyl Co-A mutase-associated GTPase MeaB
PF02310 (8/8) B12 binding domain
PF01642 (8/8) Methylmalonyl-CoA mutase
PF02737 (4/8) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00353 (4/8) RTX calcium-binding nonapeptide repeat (4 copies)
jaccard_groups_5085 683.59 +- 123.94 3 0 0 0 0.02 +- 0.01 3 7

PF16375 (3/3) Domain of unknown function
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF07944 (3/3) Beta-L-arabinofuranosidase, GH127
PF04616 (3/3) Glycosyl hydrolases family 43
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01055 (3/3) Glycosyl hydrolases family 31
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
jaccard_groups_5088 368.87 +- 10.43 3 0 0 3 0.03 +- 0.03 3 20

TIGR01656 (3/3) histidinol-phosphate phosphatase domain
TIGR01444 (3/3) methyltransferase, FkbM family
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF13242 (3/3) HAD-hyrolase-like
PF12804 (3/3) MobA-like NTP transferase domain
PF12146 (3/3) Serine aminopeptidase, S33
PF05050 (3/3) Methyltransferase FkbM domain
PF04055 (3/3) Radical SAM superfamily
PF02880 (3/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (3/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (3/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (3/3) N-terminal domain of galactosyltransferase
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (3/3) O-methyltransferase domain
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00535 (3/3) Glycosyl transferase family 2
PF00408 (3/3) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (3/3) NUDIX domain
PF00037 (2/3) 4Fe-4S binding domain
jaccard_groups_809 59.67 +- 53.23 4 0 0 0 0.13 +- 0.24 4 6

PF07690 (4/4) Major Facilitator Superfamily
PF13620 (3/4) Carboxypeptidase regulatory-like domain
PF04264 (3/4) YceI-like domain
PF01047 (3/4) MarR family
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF09335 (2/4) SNARE associated Golgi protein
jaccard_groups_5521 294.61 +- 0.00 2 0 2 0 0.04 +- 0.10 2 16

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02254 (2/2) TrkA-N domain
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01323 (2/2) DSBA-like thioredoxin domain
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
jaccard_groups_1706 103.31 +- 80.19 3 0 0 0 0.07 +- 0.10 3 6

PF13396 (3/3) Phospholipase_D-nuclease N-terminal
PF09851 (3/3) Short C-terminal domain
PF03729 (3/3) Short repeat of unknown function (DUF308)
PF17874 (2/3) MalT-like TPR region
PF07690 (2/3) Major Facilitator Superfamily
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_1098 100.50 +- 28.50 2 0 0 0 0.04 +- 0.04 2 8

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_1090 57.74 +- 38.71 3 0 1 0 0.14 +- 0.22 3 4

TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF17754 (2/3) MftR C-terminal domain
PF07690 (2/3) Major Facilitator Superfamily
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_1092 22.48 +- 9.12 9 0 0 0 0.21 +- 0.33 9 11

TIGR02937 (9/9) RNA polymerase sigma factor, sigma-70 family
TIGR00554 (9/9) pantothenate kinase
TIGR00271 (9/9) uncharacterized hydrophobic domain
PF08281 (9/9) Sigma-70, region 4
PF04542 (9/9) Sigma-70 region 2
PF04149 (9/9) Domain of unknown function (DUF397)
PF04087 (9/9) Domain of unknown function (DUF389)
PF00485 (9/9) Phosphoribulokinase / Uridine kinase family
PF13560 (8/9) Helix-turn-helix domain
PF07228 (7/9) Stage II sporulation protein E (SpoIIE)
PF00903 (6/9) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1095 99.81 +- 60.52 7 0 7 0 0.06 +- 0.12 7 4

TIGR00641 (7/7) methylmalonyl-CoA mutase N-terminal domain
PF13370 (7/7) 4Fe-4S single cluster domain of Ferredoxin I
PF01642 (7/7) Methylmalonyl-CoA mutase
PF00067 (7/7) Cytochrome P450
jaccard_groups_6241 238.98 +- 117.11 2 0 1 0 0.05 +- 0.04 2 10

PF17387 (2/2) Glycosyl hydrolase family 59 central domain
PF13407 (2/2) Periplasmic binding protein domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02057 (2/2) Glycosyl hydrolase family 59
PF00703 (2/2) Glycosyl hydrolases family 2
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
PF03466 (1/2) LysR substrate binding domain
jaccard_groups_1709 168.84 +- 121.59 9 0 7 0 0.03 +- 0.02 9 3

PF09924 (9/9) Uncharacterised conserved protein (DUF2156)
PF07690 (9/9) Major Facilitator Superfamily
PF00487 (9/9) Fatty acid desaturase
jaccard_groups_1708 35.25 +- 12.51 7 0 0 0 0.17 +- 0.19 7 7

PF12697 (7/7) Alpha/beta hydrolase family
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF02518 (7/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00106 (7/7) short chain dehydrogenase
PF00072 (7/7) Response regulator receiver domain
PF00027 (7/7) Cyclic nucleotide-binding domain
PF03625 (4/7) Domain of unknown function DUF302
jaccard_groups_1258 84.69 +- 28.14 4 0 0 0 0.03 +- 0.02 4 2

PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
jaccard_groups_6243 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain
jaccard_groups_1253 48.96 +- 67.52 4 0 0 0 0.21 +- 0.32 4 9

TIGR00234 (4/4) tyrosine--tRNA ligase
PF00579 (4/4) tRNA synthetases class I (W and Y)
TIGR03696 (3/4) RHS repeat-associated core domain
TIGR01643 (3/4) YD repeat (two copies)
PF07179 (3/4) SseB protein N-terminal domain
PF05593 (3/4) RHS Repeat
PF04149 (3/4) Domain of unknown function (DUF397)
PF01523 (3/4) Putative modulator of DNA gyrase
PF13560 (2/4) Helix-turn-helix domain
jaccard_groups_1705 55.27 +- 120.58 20 0 0 0 0.19 +- 0.13 20 5

PF13561 (20/20) Enoyl-(Acyl carrier protein) reductase
PF13193 (20/20) AMP-binding enzyme C-terminal domain
PF04909 (20/20) Amidohydrolase
PF00501 (20/20) AMP-binding enzyme
PF01575 (18/20) MaoC like domain
jaccard_groups_1704 95.87 +- 69.96 3 0 0 0 0.05 +- 0.05 3 2

PF07883 (3/3) Cupin domain
PF00248 (2/3) Aldo/keto reductase family
jaccard_groups_1255 188.26 +- 113.15 41 0 40 0 0.04 +- 0.03 41 3

PF00155 (41/41) Aminotransferase class I and II
PF11991 (40/41) Tryptophan dimethylallyltransferase
PF07690 (40/41) Major Facilitator Superfamily
jaccard_groups_1254 23.20 +- 0.44 2 0 0 0 0.09 +- 0.09 2 7

TIGR01777 (2/2) TIGR01777 family protein
PF08338 (2/2) Domain of unknown function (DUF1731)
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF04343 (1/2) Protein of unknown function, DUF488
PF01569 (1/2) PAP2 superfamily
PF01494 (1/2) FAD binding domain
PF00781 (1/2) Diacylglycerol kinase catalytic domain
jaccard_groups_117 157.89 +- 72.87 3 0 0 0 0.02 +- 0.01 3 2

PF07730 (3/3) Histidine kinase
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_114 299.93 +- 559.19 16 0 2 0 0.06 +- 0.08 16 2

PF00089 (16/16) Trypsin
PF02983 (14/16) Alpha-lytic protease prodomain
jaccard_groups_112 214.50 +- 143.98 7 0 1 0 0.02 +- 0.03 7 2

PF13517 (7/7) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF00089 (5/7) Trypsin
jaccard_groups_1894 33.79 +- 9.21 2 0 0 0 0.06 +- 0.02 2 2

PF13649 (2/2) Methyltransferase domain
PF11139 (2/2) Sap, sulfolipid-1-addressing protein
jaccard_groups_110 184.49 +- 91.25 18 0 0 0 0.05 +- 0.12 18 3

PF13545 (18/18) Crp-like helix-turn-helix domain
PF00027 (18/18) Cyclic nucleotide-binding domain
PF07228 (14/18) Stage II sporulation protein E (SpoIIE)
jaccard_groups_111 247.70 +- 407.65 81 0 79 6 0.09 +- 0.21 81 7

PF02801 (81/81) Beta-ketoacyl synthase, C-terminal domain
PF00698 (81/81) Acyl transferase domain
PF00550 (81/81) Phosphopantetheine attachment site
PF00109 (81/81) Beta-ketoacyl synthase, N-terminal domain
PF16197 (80/81) Ketoacyl-synthetase C-terminal extension
PF08659 (72/81) KR domain
PF14765 (68/81) Polyketide synthase dehydratase
jaccard_groups_118 150.01 +- 143.23 16 0 2 0 0.04 +- 0.08 16 3

PF13404 (16/16) AsnC-type helix-turn-helix domain
PF01037 (16/16) Lrp/AsnC ligand binding domain
PF00583 (8/16) Acetyltransferase (GNAT) family
jaccard_groups_119 407.52 +- 537.69 176 8 165 176 0.04 +- 0.10 168 4

TIGR03891 (176/176) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (174/176) Lantibiotic biosynthesis dehydratase C-term
PF05147 (173/176) Lanthionine synthetase C-like protein
PF04738 (171/176) Lantibiotic dehydratase, N terminus
jaccard_groups_1413 46.67 +- 32.51 24 0 8 0 0.15 +- 0.18 24 4

PF07690 (24/24) Major Facilitator Superfamily
PF05721 (24/24) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (24/24) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (24/24) Acetyltransferase (GNAT) family
jaccard_groups_4113 43.34 +- 13.14 2 0 0 0 0.18 +- 0.34 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF02687 (2/2) FtsX-like permease family
PF01526 (2/2) Tn3 transposase DDE domain
PF01494 (2/2) FAD binding domain
PF00005 (2/2) ABC transporter
PF13700 (1/2) Domain of unknown function (DUF4158)
jaccard_groups_4118 238.16 +- 71.44 2 0 0 0 0.05 +- 0.14 2 22

TIGR03971 (2/2) SDR family mycofactocin-dependent oxidoreductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
PF17939 (1/2) Tetracyclin repressor-like, C-terminal domain
PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF08531 (1/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (1/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_3817 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
jaccard_groups_3335 89.46 +- 97.76 4 0 1 0 0.05 +- 0.04 4 3

TIGR03284 (4/4) thymidylate synthase
PF00303 (4/4) Thymidylate synthase
PF00186 (4/4) Dihydrofolate reductase
jaccard_groups_3813 180.98 +- 100.93 5 0 3 0 0.08 +- 0.07 5 19

TIGR01733 (5/5) amino acid adenylation domain
PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF14765 (5/5) Polyketide synthase dehydratase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08713 (5/5) DNA alkylation repair enzyme
PF08659 (5/5) KR domain
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF01494 (5/5) FAD binding domain
PF00975 (5/5) Thioesterase domain
PF00850 (5/5) Histone deacetylase domain
PF00848 (5/5) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (5/5) Acyl transferase domain
PF00551 (5/5) Formyl transferase
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00155 (5/5) Aminotransferase class I and II
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_3819 363.58 +- 94.84 5 0 0 0 0.02 +- 0.02 5 4

PF05853 (5/5) beta-keto acid cleavage enzyme
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00171 (4/5) Aldehyde dehydrogenase family
jaccard_groups_1950 135.95 +- 113.75 18 0 1 0 0.17 +- 0.22 18 26

PF09364 (15/18) XFP N-terminal domain
PF09363 (15/18) XFP C-terminal domain
PF04879 (15/18) Molybdopterin oxidoreductase Fe4S4 domain
PF03894 (15/18) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01568 (15/18) Molydopterin dinucleotide binding domain
PF00667 (15/18) FAD binding domain
PF00384 (15/18) Molybdopterin oxidoreductase
PF00258 (15/18) Flavodoxin
PF00175 (15/18) Oxidoreductase NAD-binding domain
PF13244 (14/18) Domain of unknown function (DUF4040)
PF07690 (14/18) Major Facilitator Superfamily
PF06276 (14/18) Ferric iron reductase FhuF-like transporter
PF04183 (14/18) IucA / IucC family
PF04066 (14/18) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF02784 (14/18) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (14/18) Periplasmic binding protein
PF00420 (14/18) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (14/18) Proton-conducting membrane transporter
PF00005 (14/18) ABC transporter
PF04039 (13/18) Domain related to MnhB subunit of Na+/H+ antiporter
PF01032 (13/18) FecCD transport family
PF14759 (12/18) Reductase C-terminal
PF13535 (12/18) ATP-grasp domain
PF07992 (12/18) Pyridine nucleotide-disulphide oxidoreductase
PF18130 (9/18) ATP-grasp N-terminal domain
PF03328 (9/18) HpcH/HpaI aldolase/citrate lyase family
jaccard_groups_4625 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_4621 209.37 +- 110.73 3 0 0 0 0.05 +- 0.08 3 7

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF13474 (3/3) SnoaL-like domain
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF03795 (3/3) YCII-related domain
TIGR02246 (2/3) conserved hypothetical protein
jaccard_groups_4028 140.66 +- 30.94 2 0 0 0 0.11 +- 0.11 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12802 (2/2) MarR family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
jaccard_groups_1077 135.29 +- 122.71 2 0 0 0 0.08 +- 0.20 2 5

PF13177 (2/2) DNA polymerase III, delta subunit
PF03786 (2/2) D-mannonate dehydratase (UxuA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00118 (2/2) TCP-1/cpn60 chaperonin family
TIGR00678 (1/2) DNA polymerase III, delta' subunit
jaccard_groups_1074 21.15 +- 9.75 5 0 0 0 0.14 +- 0.14 5 2

PF01070 (5/5) FMN-dependent dehydrogenase
PF02826 (3/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_4022 187.85 +- 203.21 4 0 0 0 0.12 +- 0.29 4 6

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF02142 (4/4) MGS-like domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00994 (4/4) Probable molybdopterin binding domain
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
jaccard_groups_1079 79.29 +- 47.69 3 0 3 0 0.12 +- 0.17 3 6

TIGR02353 (3/3) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (3/3) amino acid adenylation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF17900 (2/3) Peptidase M1 N-terminal domain
PF01433 (2/3) Peptidase family M1 domain
jaccard_groups_4020 431.70 +- 504.51 4 0 0 0 0.03 +- 0.03 4 8

TIGR02100 (4/4) glycogen debranching enzyme GlgX
PF13460 (4/4) NAD(P)H-binding
PF07221 (4/4) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF02922 (4/4) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF00483 (4/4) Nucleotidyl transferase
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
PF00128 (4/4) Alpha amylase, catalytic domain
PF13546 (3/4) DDE superfamily endonuclease
jaccard_groups_4026 56.90 +- 12.37 3 0 0 0 0.17 +- 0.19 3 9

PF16262 (3/3) Domain of unknown function (DUF4916)
PF14230 (3/3) Domain of unknown function (DUF4333)
PF04909 (3/3) Amidohydrolase
PF04672 (3/3) S-adenosyl methyltransferase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00120 (3/3) Glutamine synthetase, catalytic domain
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
PF01494 (2/3) FAD binding domain
jaccard_groups_1673 19.05 +- 0.03 2 0 1 0 0.21 +- 0.12 2 9

PF12708 (2/2) Pectate lyase superfamily protein
PF07705 (2/2) CARDB
PF00754 (2/2) F5/8 type C domain
TIGR01451 (1/2) conserved repeat domain
PF17929 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13229 (1/2) Right handed beta helix region
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF01113 (1/2) Dihydrodipicolinate reductase, N-terminus
PF01040 (1/2) UbiA prenyltransferase family
jaccard_groups_1675 124.50 +- 96.64 2 0 0 0 0.06 +- 0.07 2 6

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF13463 (1/2) Winged helix DNA-binding domain
PF00155 (1/2) Aminotransferase class I and II
jaccard_groups_1674 637.90 +- 304.71 31 19 12 31 0.03 +- 0.07 12 7

TIGR03891 (31/31) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (31/31) Lantibiotic biosynthesis dehydratase C-term
PF05147 (31/31) Lanthionine synthetase C-like protein
PF04738 (31/31) Lantibiotic dehydratase, N terminus
TIGR03731 (30/31) lantibiotic, gallidermin/nisin family
PF02052 (30/31) Gallidermin
PF00005 (30/31) ABC transporter
jaccard_groups_1679 14.88 +- 1.44 28 0 0 0 0.20 +- 0.33 28 5

PF14472 (28/28) Domain of unknown function (DUF4429)
PF08241 (28/28) Methyltransferase domain
PF00106 (28/28) short chain dehydrogenase
PF09851 (27/28) Short C-terminal domain
PF13231 (26/28) Dolichyl-phosphate-mannose-protein mannosyltransferase
jaccard_groups_1678 270.77 +- 162.57 28 0 28 0 0.04 +- 0.10 28 13

TIGR00709 (28/28) 2,4-diaminobutyrate 4-transaminase
TIGR00657 (28/28) aspartate kinase
PF13434 (28/28) L-lysine 6-monooxygenase (NADPH-requiring)
PF07690 (28/28) Major Facilitator Superfamily
PF04204 (28/28) Homoserine O-succinyltransferase
PF00696 (28/28) Amino acid kinase family
PF00202 (28/28) Aminotransferase class-III
PF00668 (26/28) Condensation domain
PF00501 (26/28) AMP-binding enzyme
TIGR01733 (25/28) amino acid adenylation domain
PF13193 (25/28) AMP-binding enzyme C-terminal domain
PF00975 (25/28) Thioesterase domain
PF00550 (25/28) Phosphopantetheine attachment site
jaccard_groups_4931 111.13 +- 95.50 3 0 0 0 0.10 +- 0.18 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF16347 (3/3) Domain of unknown function (DUF4976)
PF13560 (3/3) Helix-turn-helix domain
PF09992 (3/3) Phosphodiester glycosidase
PF05036 (3/3) Sporulation related domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF04149 (3/3) Domain of unknown function (DUF397)
PF00884 (3/3) Sulfatase
PF00756 (3/3) Putative esterase
jaccard_groups_4933 345.72 +- 399.02 3 0 0 0 0.08 +- 0.26 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF11136 (3/3) Protein of unknown function (DUF2889)
PF04879 (3/3) Molybdopterin oxidoreductase Fe4S4 domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00501 (3/3) AMP-binding enzyme
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00384 (3/3) Molybdopterin oxidoreductase
PF00106 (3/3) short chain dehydrogenase
PF03807 (2/3) NADP oxidoreductase coenzyme F420-dependent
jaccard_groups_4932 229.15 +- 86.06 3 0 0 0 0.07 +- 0.06 3 10

TIGR01728 (3/3) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF16347 (3/3) Domain of unknown function (DUF4976)
PF09084 (3/3) NMT1/THI5 like
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF00884 (3/3) Sulfatase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00480 (3/3) ROK family
PF00005 (3/3) ABC transporter
PF13412 (2/3) Winged helix-turn-helix DNA-binding
PF04909 (2/3) Amidohydrolase
jaccard_groups_3259 1137.62 +- 402.20 7 0 2 0 0.01 +- 0.01 7 7

PF08892 (7/7) YqcI/YcgG family
PF08241 (7/7) Methyltransferase domain
PF07690 (7/7) Major Facilitator Superfamily
PF01725 (7/7) Ham1 family
PF00590 (7/7) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
PF13480 (6/7) Acetyltransferase (GNAT) domain
jaccard_groups_3258 31.79 +- 23.17 3 0 0 0 0.10 +- 0.10 3 3

PF00583 (3/3) Acetyltransferase (GNAT) family
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00296 (3/3) Luciferase-like monooxygenase
jaccard_groups_4244 285.17 +- 3.72 2 0 0 0 0.03 +- 0.03 2 5

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF01425 (2/2) Amidase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13546 (1/2) DDE superfamily endonuclease
PF01526 (1/2) Tn3 transposase DDE domain
jaccard_groups_3255 281.24 +- 190.00 3 0 1 0 0.09 +- 0.17 3 3

PF12697 (3/3) Alpha/beta hydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF00884 (2/3) Sulfatase
jaccard_groups_4938 545.63 +- 267.95 3 0 1 0 0.02 +- 0.03 3 10

PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF01266 (3/3) FAD dependent oxidoreductase
PF00856 (3/3) SET domain
PF09334 (2/3) tRNA synthetases class I (M)
PF07883 (2/3) Cupin domain
PF07690 (2/3) Major Facilitator Superfamily
PF00561 (2/3) alpha/beta hydrolase fold
jaccard_groups_3250 387.82 +- 122.11 5 0 0 0 0.01 +- 0.01 5 5

PF16859 (5/5) Tetracyclin repressor-like, C-terminal domain
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF01243 (5/5) Pyridoxamine 5'-phosphate oxidase
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_3252 183.44 +- 201.57 4 0 0 0 0.06 +- 0.14 4 6

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00107 (4/4) Zinc-binding dehydrogenase
PF00440 (2/4) Bacterial regulatory proteins, tetR family
PF00248 (2/4) Aldo/keto reductase family
jaccard_groups_36 180.06 +- 207.02 15 0 1 0 0.04 +- 0.09 15 1

PF01636 (15/15) Phosphotransferase enzyme family
jaccard_groups_37 151.17 +- 128.78 36 0 7 0 0.04 +- 0.07 36 1

PF00106 (36/36) short chain dehydrogenase
jaccard_groups_34 433.66 +- 577.47 84 0 18 2 0.09 +- 0.20 84 5

PF00005 (83/84) ABC transporter
PF08352 (82/84) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (82/84) Binding-protein-dependent transport system inner membrane component
PF00496 (82/84) Bacterial extracellular solute-binding proteins, family 5 Middle
TIGR01727 (67/84) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
jaccard_groups_35 88.27 +- 104.12 6 0 0 0 0.15 +- 0.26 6 8

TIGR02980 (6/6) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (6/6) Sigma-70, region 4
PF04542 (6/6) Sigma-70 region 2
PF04539 (6/6) Sigma-70 region 3
PF14087 (4/6) Domain of unknown function (DUF4267)
PF13649 (4/6) Methyltransferase domain
PF01590 (4/6) GAF domain
PF00583 (4/6) Acetyltransferase (GNAT) family
jaccard_groups_32 121.89 +- 122.68 9 0 1 0 0.07 +- 0.12 9 3

PF13561 (9/9) Enoyl-(Acyl carrier protein) reductase
PF00293 (5/9) NUDIX domain
PF00106 (5/9) short chain dehydrogenase
jaccard_groups_33 27.73 +- 10.48 4 0 0 0 0.12 +- 0.21 4 7

PF12728 (4/4) Helix-turn-helix domain
PF00589 (4/4) Phage integrase family
PF09250 (3/4) Bifunctional DNA primase/polymerase, N-terminal
TIGR01764 (2/4) DNA binding domain, excisionase family
PF11750 (2/4) Protein of unknown function (DUF3307)
PF10935 (2/4) Protein of unknown function (DUF2637)
PF05707 (2/4) Zonular occludens toxin (Zot)
jaccard_groups_30 349.12 +- 505.00 362 0 355 6 0.09 +- 0.22 362 7

PF00501 (362/362) AMP-binding enzyme
PF00550 (359/362) Phosphopantetheine attachment site
PF13193 (357/362) AMP-binding enzyme C-terminal domain
TIGR01733 (353/362) amino acid adenylation domain
PF00668 (332/362) Condensation domain
PF00975 (247/362) Thioesterase domain
PF03621 (217/362) MbtH-like protein
jaccard_groups_31 107.50 +- 133.43 66 0 27 0 0.10 +- 0.15 66 1

PF00067 (66/66) Cytochrome P450
jaccard_groups_38 233.68 +- 274.56 11 0 3 0 0.05 +- 0.07 11 1

PF07228 (11/11) Stage II sporulation protein E (SpoIIE)
jaccard_groups_39 109.72 +- 100.07 62 0 5 0 0.05 +- 0.09 62 1

PF00561 (62/62) alpha/beta hydrolase fold
jaccard_groups_336 130.85 +- 156.82 8 0 2 0 0.12 +- 0.16 8 2

PF10604 (8/8) Polyketide cyclase / dehydrase and lipid transport
PF00248 (4/8) Aldo/keto reductase family
jaccard_groups_337 134.65 +- 173.78 26 0 11 1 0.07 +- 0.11 26 2

PF05199 (26/26) GMC oxidoreductase
PF00732 (25/26) GMC oxidoreductase
jaccard_groups_3921 26.75 +- 3.45 5 0 0 0 0.08 +- 0.14 5 14

TIGR02680 (5/5) TIGR02680 family protein
TIGR02678 (5/5) TIGR02678 family protein
TIGR02677 (5/5) TIGR02677 family protein
TIGR00484 (5/5) translation elongation factor G
PF14492 (5/5) Elongation Factor G, domain II
PF13558 (5/5) Putative exonuclease SbcCD, C subunit
PF10127 (5/5) RNA repair pathway DNA polymerase beta family
PF09983 (5/5) Uncharacterized protein conserved in bacteria C-term(DUF2220)
PF09661 (5/5) Protein of unknown function (DUF2398)
PF09660 (5/5) Protein of unknown function (DUF2397)
PF03764 (5/5) Elongation factor G, domain IV
PF03144 (5/5) Elongation factor Tu domain 2
PF00679 (5/5) Elongation factor G C-terminus
PF00009 (5/5) Elongation factor Tu GTP binding domain
jaccard_groups_335 75.73 +- 67.26 12 0 1 0 0.15 +- 0.25 12 13

TIGR04382 (12/12) 5-dehydro-2-deoxygluconokinase
TIGR04377 (12/12) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
PF02776 (12/12) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (12/12) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00294 (12/12) pfkB family carbohydrate kinase
PF00205 (12/12) Thiamine pyrophosphate enzyme, central domain
TIGR04378 (11/12) 5-deoxy-glucuronate isomerase
PF04962 (11/12) KduI/IolB family
PF01408 (11/12) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (11/12) Xylose isomerase-like TIM barrel
TIGR01722 (10/12) methylmalonate-semialdehyde dehydrogenase (acylating)
PF02894 (10/12) Oxidoreductase family, C-terminal alpha/beta domain
PF00171 (10/12) Aldehyde dehydrogenase family
jaccard_groups_333 142.10 +- 104.36 10 0 1 0 0.06 +- 0.13 10 1

PF01738 (10/10) Dienelactone hydrolase family
jaccard_groups_330 80.94 +- 55.30 5 0 1 0 0.05 +- 0.07 5 4

TIGR01494 (5/5) HAD ATPase, P-type, family IC
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00689 (5/5) Cation transporting ATPase, C-terminus
PF00122 (4/5) E1-E2 ATPase
jaccard_groups_4801 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
jaccard_groups_6262 523.42 +- 54.35 2 0 2 2 0.05 +- 0.08 2 18

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13575 (2/2) Domain of unknown function (DUF4135)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00664 (2/2) ABC transporter transmembrane region
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07366 (1/2) SnoaL-like polyketide cyclase
jaccard_groups_241 65.01 +- 66.77 12 0 1 0 0.08 +- 0.12 12 1

PF01425 (12/12) Amidase
jaccard_groups_246 45.98 +- 60.85 10 0 0 0 0.10 +- 0.10 10 5

PF02913 (10/10) FAD linked oxidases, C-terminal domain
PF01565 (10/10) FAD binding domain
PF13183 (8/10) 4Fe-4S dicluster domain
PF02754 (8/10) Cysteine-rich domain
PF00202 (5/10) Aminotransferase class-III
jaccard_groups_247 287.15 +- 261.52 13 2 11 13 0.04 +- 0.11 11 7

TIGR03897 (13/13) type 2 lantibiotic biosynthesis protein LanM
PF13575 (13/13) Domain of unknown function (DUF4135)
PF05147 (13/13) Lanthionine synthetase C-like protein
PF03704 (8/13) Bacterial transcriptional activator domain
PF00486 (8/13) Transcriptional regulatory protein, C terminal
PF13191 (7/13) AAA ATPase domain
PF00196 (7/13) Bacterial regulatory proteins, luxR family
jaccard_groups_245 37.27 +- 20.51 2 0 1 0 0.11 +- 0.17 2 3

PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF05621 (1/2) Bacterial TniB protein
jaccard_groups_248 276.28 +- 201.50 16 0 2 16 0.03 +- 0.07 16 2

PF04055 (16/16) Radical SAM superfamily
PF13186 (8/16) Iron-sulfur cluster-binding domain
jaccard_groups_747 17.76 +- 4.75 3 0 0 0 0.19 +- 0.38 3 5

TIGR01341 (3/3) aconitate hydratase 1
PF00694 (3/3) Aconitase C-terminal domain
PF00330 (3/3) Aconitase family (aconitate hydratase)
TIGR03083 (2/3) uncharacterized Actinobacterial protein TIGR03083
PF00704 (2/3) Glycosyl hydrolases family 18
jaccard_groups_743 245.10 +- 141.90 2 0 0 0 0.01 +- 0.01 2 5

TIGR00674 (2/2) 4-hydroxy-tetrahydrodipicolinate synthase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF12277 (1/2) Protein of unknown function (DUF3618)
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07332 (1/2) Putative Actinobacterial Holin-X, holin superfamily III
jaccard_groups_742 108.92 +- 133.56 13 0 1 0 0.07 +- 0.08 13 2

PF08007 (13/13) Cupin superfamily protein
PF06999 (11/13) Sucrase/ferredoxin-like
jaccard_groups_740 53.66 +- 61.77 18 0 1 0 0.10 +- 0.13 18 3

PF01522 (18/18) Polysaccharide deacetylase
PF00535 (17/18) Glycosyl transferase family 2
PF13480 (15/18) Acetyltransferase (GNAT) domain
jaccard_groups_3104 312.70 +- 96.50 8 0 2 0 0.04 +- 0.01 8 7

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF09339 (7/8) IclR helix-turn-helix domain
PF02826 (6/8) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01614 (6/8) Bacterial transcriptional regulator
PF02894 (4/8) Oxidoreductase family, C-terminal alpha/beta domain
jaccard_groups_6408 159.00 +- 17.98 2 0 0 0 0.11 +- 0.16 2 21

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13380 (2/2) CoA binding domain
PF09084 (2/2) NMT1/THI5 like
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04016 (2/2) Putative heavy-metal chelation
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13549 (1/2) ATP-grasp domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00285 (1/2) Citrate synthase, C-terminal domain
jaccard_groups_3109 64.26 +- 49.54 8 0 0 0 0.09 +- 0.11 8 8

TIGR04350 (8/8) putative C-S lyase
PF18105 (8/8) PGM1 C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF00155 (8/8) Aminotransferase class I and II
PF14100 (5/8) Methane oxygenase PmoA
PF02894 (5/8) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/8) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_3108 20.07 +- 6.05 8 0 8 0 0.18 +- 0.23 8 6

PF13354 (8/8) Beta-lactamase enzyme family
PF01380 (8/8) SIS domain
PF01116 (8/8) Fructose-bisphosphate aldolase class-II
PF00126 (8/8) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR00167 (7/8) ketose-bisphosphate aldolase
PF03466 (7/8) LysR substrate binding domain
jaccard_groups_5788 82.94 +- 3.90 2 0 0 0 0.22 +- 0.37 2 15

TIGR01353 (2/2) putative dGTPase
TIGR00389 (2/2) glycine--tRNA ligase
PF13286 (2/2) Phosphohydrolase-associated domain
PF07730 (2/2) Histidine kinase
PF04203 (2/2) Sortase domain
PF03129 (2/2) Anticodon binding domain
PF02698 (2/2) DUF218 domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01966 (2/2) HD domain
PF01061 (2/2) ABC-2 type transporter
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00079 (2/2) Serpin (serine protease inhibitor)
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
jaccard_groups_6069 3900.00 +- 780.00 2 0 2 2 0.01 +- 0.00 2 10

TIGR04267 (2/2) HEXXH motif domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF13535 (2/2) ATP-grasp domain
PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
jaccard_groups_3516 126.90 +- 10.85 2 0 0 1 0.11 +- 0.19 2 17

PF06314 (2/2) Acetoacetate decarboxylase (ADC)
PF03466 (2/2) LysR substrate binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (2/2) CoA-transferase family III
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF13458 (1/2) Periplasmic binding protein
PF13411 (1/2) MerR HTH family regulatory protein
PF07690 (1/2) Major Facilitator Superfamily
PF06445 (1/2) GyrI-like small molecule binding domain
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_3034 63.82 +- 5.91 2 0 0 0 0.18 +- 0.21 2 12

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF12172 (1/2) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF01204 (1/2) Trehalase
PF01012 (1/2) Electron transfer flavoprotein domain
PF00766 (1/2) Electron transfer flavoprotein FAD-binding domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_3517 344.79 +- 140.15 5 0 0 0 0.03 +- 0.04 5 20

PF17853 (5/5) GGDEF-like domain
PF16483 (5/5) Beta-1,3-glucanase
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12077 (5/5) Transmembrane protein of unknown function (DUF3556)
PF06314 (5/5) Acetoacetate decarboxylase (ADC)
PF03466 (5/5) LysR substrate binding domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02737 (5/5) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (5/5) CoA-transferase family III
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00754 (5/5) F5/8 type C domain
PF00725 (5/5) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (5/5) Enoyl-CoA hydratase/isomerase
PF00324 (5/5) Amino acid permease
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_2037 339.02 +- 305.98 4 0 0 0 0.13 +- 0.23 4 11

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
PF13581 (4/4) Histidine kinase-like ATPase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF10099 (4/4) Anti-sigma-K factor rskA
PF08281 (4/4) Sigma-70, region 4
PF07103 (4/4) Protein of unknown function (DUF1365)
PF06966 (4/4) Protein of unknown function (DUF1295)
PF04542 (4/4) Sigma-70 region 2
PF02353 (4/4) Mycolic acid cyclopropane synthetase
PF01593 (4/4) Flavin containing amine oxidoreductase
PF13490 (3/4) Putative zinc-finger
jaccard_groups_2034 51.81 +- 34.42 4 0 0 0 0.11 +- 0.08 4 5

PF07969 (4/4) Amidohydrolase family
PF07681 (4/4) DoxX
PF00857 (4/4) Isochorismatase family
PF14542 (3/4) GCN5-related N-acetyl-transferase
PF06912 (3/4) Protein of unknown function (DUF1275)
jaccard_groups_2032 75.62 +- 54.92 9 0 1 0 0.16 +- 0.27 9 5

PF00083 (9/9) Sugar (and other) transporter
TIGR00879 (8/9) MFS transporter, sugar porter (SP) family
PF01261 (8/9) Xylose isomerase-like TIM barrel
PF02894 (7/9) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (7/9) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_6066 287.38 +- 128.62 2 0 2 0 0.02 +- 0.02 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF07730 (2/2) Histidine kinase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00122 (2/2) E1-E2 ATPase
PF00072 (2/2) Response regulator receiver domain
jaccard_groups_3044 392.47 +- 335.56 3 0 3 0 0.06 +- 0.17 3 19

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF14525 (3/3) AraC-binding-like domain
PF13349 (3/3) Putative adhesin
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12833 (3/3) Helix-turn-helix domain
PF05977 (3/3) Transmembrane secretion effector
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF03176 (3/3) MMPL family
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01022 (3/3) Bacterial regulatory protein, arsR family
PF00975 (3/3) Thioesterase domain
PF00931 (3/3) NB-ARC domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00144 (3/3) Beta-lactamase
jaccard_groups_633 17.04 +- 6.64 7 0 3 0 0.18 +- 0.21 7 5

TIGR00537 (6/7) putative methylase
PF09360 (6/7) Iron-binding zinc finger CDGSH type
PF05175 (6/7) Methyltransferase small domain
PF01266 (4/7) FAD dependent oxidoreductase
PF00355 (4/7) Rieske [2Fe-2S] domain
jaccard_groups_6081 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_630 93.78 +- 234.76 21 0 2 0 0.12 +- 0.13 21 3

PF17801 (21/21) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (21/21) Alpha galactosidase A
PF00652 (21/21) Ricin-type beta-trefoil lectin domain
jaccard_groups_634 65.39 +- 45.98 53 3 10 52 0.07 +- 0.05 50 4

PF13575 (53/53) Domain of unknown function (DUF4135)
PF05147 (52/53) Lanthionine synthetase C-like protein
PF08007 (43/53) Cupin superfamily protein
PF06189 (40/53) 5'-nucleotidase
jaccard_groups_639 106.58 +- 255.33 20 0 14 0 0.10 +- 0.10 20 4

TIGR00055 (20/20) di-trans,poly-cis-decaprenylcistransferase
PF01255 (20/20) Putative undecaprenyl diphosphate synthase
PF13202 (14/20) EF hand
PF09995 (14/20) Uncharacterized protein conserved in bacteria (DUF2236)
jaccard_groups_3511 181.48 +- 56.68 2 0 0 0 0.02 +- 0.03 2 5

PF13458 (2/2) Periplasmic binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
jaccard_groups_3743 209.51 +- 120.37 5 0 0 0 0.07 +- 0.15 5 6

PF13305 (5/5) Tetracyclin repressor-like, C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF05922 (5/5) Peptidase inhibitor I9
PF00535 (5/5) Glycosyl transferase family 2
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00082 (5/5) Subtilase family
jaccard_groups_6312 14.99 +- 0.81 2 0 0 0 0.13 +- 0.17 2 3

PF16375 (2/2) Domain of unknown function
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
jaccard_groups_2342 28.07 +- 6.79 7 0 0 0 0.12 +- 0.14 7 5

PF13517 (7/7) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (7/7) Acetyltransferase (GNAT) domain
PF07690 (7/7) Major Facilitator Superfamily
PF00089 (7/7) Trypsin
PF12867 (6/7) DinB superfamily
jaccard_groups_6310 61.37 +- 13.71 2 0 0 0 0.17 +- 0.33 2 13

TIGR02246 (2/2) conserved hypothetical protein
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF14478 (2/2) Domain of unknown function (DUF4430)
PF13649 (2/2) Methyltransferase domain
PF12822 (2/2) ECF transporter, substrate-specific component
PF04314 (2/2) Copper chaperone PCu(A)C
PF02361 (2/2) Cobalt transport protein
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
jaccard_groups_6317 72.37 +- 12.06 2 0 0 0 0.06 +- 0.01 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13535 (2/2) ATP-grasp domain
PF13394 (2/2) 4Fe-4S single cluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00355 (2/2) Rieske [2Fe-2S] domain
jaccard_groups_2610 120.04 +- 42.04 2 0 0 0 0.06 +- 0.08 2 8

TIGR01979 (2/2) cysteine desulfurase, SufS family
PF03466 (2/2) LysR substrate binding domain
PF00266 (2/2) Aminotransferase class-V
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00027 (2/2) Cyclic nucleotide-binding domain
PF14065 (1/2) Protein of unknown function (DUF4255)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
jaccard_groups_6314 34.77 +- 11.31 2 0 1 0 0.12 +- 0.11 2 7

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF13529 (1/2) Peptidase_C39 like family
PF00931 (1/2) NB-ARC domain
jaccard_groups_2348 702.94 +- 543.13 14 0 14 0 0.02 +- 0.01 14 14

TIGR01850 (14/14) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (14/14) alpha-L-glutamate ligase, RimK family
PF08443 (14/14) RimK-like ATP-grasp domain
PF02780 (14/14) Transketolase, C-terminal domain
PF02779 (14/14) Transketolase, pyrimidine binding domain
PF01118 (14/14) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (14/14) Transketolase, thiamine diphosphate binding domain
PF13193 (13/14) AMP-binding enzyme C-terminal domain
PF02771 (13/14) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (13/14) Acyl-CoA dehydrogenase, middle domain
PF00501 (13/14) AMP-binding enzyme
PF00441 (13/14) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (10/14) LysR substrate binding domain
PF00126 (10/14) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_5564 37.64 +- 1.30 2 0 0 0 0.17 +- 0.26 2 6

TIGR01426 (2/2) glycosyltransferase, MGT family
PF00535 (2/2) Glycosyl transferase family 2
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00082 (2/2) Subtilase family
PF01636 (1/2) Phosphotransferase enzyme family
PF00089 (1/2) Trypsin
jaccard_groups_5629 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_2720 75.88 +- 27.90 7 0 4 0 0.08 +- 0.10 7 6

PF13649 (7/7) Methyltransferase domain
PF02784 (7/7) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
PF00266 (7/7) Aminotransferase class-V
PF00581 (6/7) Rhodanese-like domain
PF00278 (6/7) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
jaccard_groups_3696 36.92 +- 10.61 3 0 2 0 0.09 +- 0.17 3 6

PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01471 (3/3) Putative peptidoglycan binding domain
TIGR00040 (2/3) phosphodiesterase, MJ0936 family
PF12850 (2/3) Calcineurin-like phosphoesterase superfamily domain
PF12802 (2/3) MarR family
PF05257 (2/3) CHAP domain
jaccard_groups_2724 75.72 +- 9.61 8 0 8 0 0.04 +- 0.05 8 5

PF13394 (8/8) 4Fe-4S single cluster domain
PF13377 (8/8) Periplasmic binding protein-like domain
PF01242 (8/8) 6-pyruvoyl tetrahydropterin synthase
PF01227 (8/8) GTP cyclohydrolase I
PF00356 (8/8) Bacterial regulatory proteins, lacI family
jaccard_groups_5413 254.85 +- 197.32 2 0 2 2 0.07 +- 0.22 2 12

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF18085 (2/2) Maltokinase N-terminal cap domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01757 (2/2) Acyltransferase family
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00092 (1/2) GTP-binding protein YchF
PF06071 (1/2) Protein of unknown function (DUF933)
PF01926 (1/2) 50S ribosome-binding GTPase
jaccard_groups_5414 48.84 +- 13.25 2 0 0 0 0.08 +- 0.15 2 6

PF01757 (2/2) Acyltransferase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF12802 (1/2) MarR family
PF08242 (1/2) Methyltransferase domain
PF01522 (1/2) Polysaccharide deacetylase
jaccard_groups_3690 215.27 +- 98.42 5 0 5 4 0.04 +- 0.05 5 11

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
PF10025 (5/5) Uncharacterized conserved protein (DUF2267)
PF08281 (5/5) Sigma-70, region 4
PF04542 (5/5) Sigma-70 region 2
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00067 (5/5) Cytochrome P450
TIGR03975 (4/5) ribosomal peptide maturation radical SAM protein 1
PF07690 (4/5) Major Facilitator Superfamily
PF04055 (4/5) Radical SAM superfamily
PF02310 (4/5) B12 binding domain
PF00326 (4/5) Prolyl oligopeptidase family
jaccard_groups_2297 226.23 +- 76.62 10 0 0 0 0.05 +- 0.04 10 10

TIGR00976 (10/10) hydrolase CocE/NonD family protein
PF08530 (10/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (10/10) alpha/beta hydrolase fold
PF02129 (10/10) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (10/10) Phosphotriesterase family
PF01494 (10/10) FAD binding domain
PF00753 (10/10) Metallo-beta-lactamase superfamily
PF07690 (9/10) Major Facilitator Superfamily
PF03781 (9/10) Sulfatase-modifying factor enzyme 1
PF00884 (9/10) Sulfatase
jaccard_groups_5960 1573.84 +- 732.99 2 0 2 0 0.02 +- 0.03 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01214 (2/2) dTDP-4-dehydrorhamnose reductase
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16861 (2/2) Carbamoyltransferase C-terminus
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF08484 (2/2) C-methyltransferase C-terminal domain
PF08421 (2/2) Putative zinc binding domain
PF06722 (2/2) Protein of unknown function (DUF1205)
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04321 (2/2) RmlD substrate binding domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02195 (2/2) ParB-like nuclease domain
PF02153 (2/2) Prephenate dehydrogenase
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
jaccard_groups_5963 245.92 +- 75.21 2 0 0 0 0.06 +- 0.13 2 14

PF13802 (2/2) Galactose mutarotase-like
PF13641 (2/2) Glycosyltransferase like family 2
PF13570 (2/2) PQQ-like domain
PF06182 (2/2) ABC-2 family transporter protein
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF01055 (2/2) Glycosyl hydrolases family 31
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00005 (2/2) ABC transporter
PF13377 (1/2) Periplasmic binding protein-like domain
PF00877 (1/2) NlpC/P60 family
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_5962 439.24 +- 91.93 2 0 0 0 0.02 +- 0.01 2 9

PF16884 (2/2) N-terminal domain of oxidoreductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
jaccard_groups_2119 103.89 +- 71.03 3 0 0 0 0.10 +- 0.11 3 8

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13523 (3/3) Acetyltransferase (GNAT) domain
PF06172 (3/3) Cupin superfamily (DUF985)
PF01804 (3/3) Penicillin amidase
PF05425 (2/3) Copper resistance protein D
PF04234 (2/3) CopC domain
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
jaccard_groups_2508 939.25 +- 87.33 2 0 2 2 0.03 +- 0.03 2 23

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR01760 (2/2) phage tail tape measure protein, TP901 family, core region
PF16945 (2/2) Putative lactococcus lactis phage r1t holin
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13830 (2/2) Domain of unknown function (DUF4192)
PF10145 (2/2) Phage-related minor tail protein
PF05709 (2/2) Phage tail protein
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04883 (2/2) Bacteriophage HK97-gp10, putative tail-component
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03837 (2/2) RecT family
PF02384 (2/2) N-6 DNA Methylase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01507 (2/2) Phosphoadenosine phosphosulfate reductase family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00216 (2/2) Bacterial DNA-binding protein
PF00145 (2/2) C-5 cytosine-specific DNA methylase
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13576 (1/2) Pentapeptide repeats (9 copies)
PF09339 (1/2) IclR helix-turn-helix domain
PF08007 (1/2) Cupin superfamily protein
jaccard_groups_2500 259.00 +- 1.00 2 0 0 2 0.01 +- 0.00 2 4

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF04055 (2/2) Radical SAM superfamily
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF01909 (1/2) Nucleotidyltransferase domain
jaccard_groups_2504 566.64 +- 355.75 13 0 13 0 0.03 +- 0.09 13 31

TIGR02087 (13/13) 3-isopropylmalate dehydratase, small subunit
TIGR00566 (13/13) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (13/13) aminodeoxychorismate synthase, component I
PF13673 (13/13) Acetyltransferase (GNAT) domain
PF13649 (13/13) Methyltransferase domain
PF07690 (13/13) Major Facilitator Superfamily
PF04715 (13/13) Anthranilate synthase component I, N terminal region
PF01817 (13/13) Chorismate mutase type II
PF01474 (13/13) Class-II DAHP synthetase family
PF01063 (13/13) Amino-transferase class IV
PF00850 (13/13) Histone deacetylase domain
PF00694 (13/13) Aconitase C-terminal domain
PF00682 (13/13) HMGL-like
PF00425 (13/13) chorismate binding enzyme
PF00330 (13/13) Aconitase family (aconitate hydratase)
PF00180 (13/13) Isocitrate/isopropylmalate dehydrogenase
PF00117 (13/13) Glutamine amidotransferase class-I
TIGR01733 (11/13) amino acid adenylation domain
PF16197 (11/13) Ketoacyl-synthetase C-terminal extension
PF14765 (11/13) Polyketide synthase dehydratase
PF13480 (11/13) Acetyltransferase (GNAT) domain
PF13193 (11/13) AMP-binding enzyme C-terminal domain
PF08659 (11/13) KR domain
PF02801 (11/13) Beta-ketoacyl synthase, C-terminal domain
PF00698 (11/13) Acyl transferase domain
PF00668 (11/13) Condensation domain
PF00550 (11/13) Phosphopantetheine attachment site
PF00501 (11/13) AMP-binding enzyme
PF00109 (11/13) Beta-ketoacyl synthase, N-terminal domain
PF05977 (10/13) Transmembrane secretion effector
PF00975 (10/13) Thioesterase domain
jaccard_groups_5981 257.11 +- 103.59 2 0 0 0 0.08 +- 0.17 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00037 (2/2) 4Fe-4S binding domain
PF00005 (2/2) ABC transporter
PF01575 (1/2) MaoC like domain
jaccard_groups_5988 41.81 +- 4.50 2 0 0 0 0.17 +- 0.18 2 7

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07398 (2/2) MDMPI C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
jaccard_groups_5862 388.50 +- 1.50 2 0 0 2 0.01 +- 0.00 2 3

PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01266 (2/2) FAD dependent oxidoreductase
PF00881 (2/2) Nitroreductase family
jaccard_groups_927 224.74 +- 286.58 23 0 5 1 0.10 +- 0.16 23 5

PF07748 (23/23) Glycosyl hydrolases family 38 C-terminal domain
PF01074 (23/23) Glycosyl hydrolases family 38 N-terminal domain
PF17677 (22/23) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF09261 (22/23) Alpha mannosidase middle domain
PF00528 (18/23) Binding-protein-dependent transport system inner membrane component
jaccard_groups_925 39.84 +- 24.60 7 0 1 0 0.08 +- 0.08 7 6

PF13493 (7/7) Domain of unknown function (DUF4118)
PF02702 (7/7) Osmosensitive K+ channel His kinase sensor domain
PF02518 (7/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00582 (7/7) Universal stress protein family
PF00512 (7/7) His Kinase A (phospho-acceptor) domain
PF02254 (4/7) TrkA-N domain
jaccard_groups_924 903.17 +- 1377.70 13 0 1 0 0.08 +- 0.21 13 5

PF02653 (13/13) Branched-chain amino acid transport system / permease component
PF13458 (12/13) Periplasmic binding protein
PF12399 (12/13) Branched-chain amino acid ATP-binding cassette transporter
PF00005 (12/13) ABC transporter
PF00501 (7/13) AMP-binding enzyme
jaccard_groups_921 51.80 +- 18.77 5 0 0 0 0.13 +- 0.18 5 5

TIGR00589 (5/5) methylated-DNA--[protein]-cysteine S-methyltransferase
PF07690 (5/5) Major Facilitator Superfamily
PF03009 (5/5) Glycerophosphoryl diester phosphodiesterase family
PF01035 (5/5) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF02870 (3/5) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
jaccard_groups_929 235.64 +- 127.23 10 0 0 0 0.06 +- 0.14 10 14

TIGR02138 (10/10) phosphate ABC transporter, permease protein PstC
TIGR00974 (10/10) phosphate ABC transporter, permease protein PstA
PF12849 (10/10) PBP superfamily domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00005 (10/10) ABC transporter
TIGR00972 (9/10) phosphate ABC transporter, ATP-binding protein
PF16640 (9/10) Bacterial Ig-like domain (group 3)
PF04203 (9/10) Sortase domain
PF00041 (8/10) Fibronectin type III domain
PF18431 (6/10) Bacterial CdiA-CT RNAse A domain
PF06013 (6/10) Proteins of 100 residues with WXG
PF05908 (6/10) Poly-gamma-glutamate hydrolase
TIGR01076 (5/10) sortase
PF18593 (5/10) CdiI immunity protein
jaccard_groups_5347 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_5341 56.49 +- 37.65 2 0 0 0 0.08 +- 0.11 2 5

PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08357 (2/2) SEFIR domain
PF00348 (2/2) Polyprenyl synthetase
PF13676 (1/2) TIR domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
jaccard_groups_5340 120.84 +- 25.99 2 0 2 0 0.09 +- 0.09 2 12

PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF04183 (2/2) IucA / IucC family
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (2/2) Periplasmic binding protein
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF01032 (1/2) FecCD transport family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00005 (1/2) ABC transporter
jaccard_groups_5349 14.31 +- 0.32 2 0 0 0 0.21 +- 0.24 2 7

TIGR01581 (2/2) NifC-like ABC-type porter
PF08544 (2/2) GHMP kinases C terminal
PF03459 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
jaccard_groups_5189 2274.26 +- 2061.56 3 0 2 0 0.03 +- 0.13 3 24

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02633 (3/3) Creatinine amidohydrolase
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF01180 (3/3) Dihydroorotate dehydrogenase
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00534 (3/3) Glycosyl transferases group 1
PF00483 (3/3) Nucleotidyl transferase
PF00171 (3/3) Aldehyde dehydrogenase family
PF00107 (3/3) Zinc-binding dehydrogenase
TIGR01733 (2/3) amino acid adenylation domain
PF13649 (2/3) Methyltransferase domain
PF13579 (2/3) Glycosyl transferase 4-like domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF04909 (2/3) Amidohydrolase
PF02449 (2/3) Beta-galactosidase
PF00668 (2/3) Condensation domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_5180 45.07 +- 5.68 2 0 0 0 0.10 +- 0.10 2 7

TIGR00879 (2/2) MFS transporter, sugar porter (SP) family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01910 (2/2) Thiamine-binding protein
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
PF06114 (1/2) IrrE N-terminal-like domain
jaccard_groups_5187 675.05 +- 415.45 3 0 0 0 0.08 +- 0.21 3 9

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF02780 (3/3) Transketolase, C-terminal domain
PF02779 (3/3) Transketolase, pyrimidine binding domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF00456 (3/3) Transketolase, thiamine diphosphate binding domain
PF00005 (3/3) ABC transporter
PF07690 (2/3) Major Facilitator Superfamily
PF04199 (2/3) Putative cyclase
jaccard_groups_5185 228.36 +- 13.36 2 0 2 0 0.17 +- 0.30 2 24

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF18369 (1/2) Polyketide synthase dimerisation element domain
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13191 (1/2) AAA ATPase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_5184 251.02 +- 123.71 3 0 0 0 0.03 +- 0.05 3 9

TIGR00481 (3/3) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01494 (3/3) FAD binding domain
PF01161 (3/3) Phosphatidylethanolamine-binding protein
PF01042 (3/3) Endoribonuclease L-PSP
PF00107 (3/3) Zinc-binding dehydrogenase
PF01557 (2/3) Fumarylacetoacetate (FAA) hydrolase family
jaccard_groups_5741 18.08 +- 0.35 2 0 2 2 0.17 +- 0.33 2 6

PF17885 (2/2) Styrene monooxygenase A putative substrate binding domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00494 (2/2) Squalene/phytoene synthase
PF00069 (2/2) Protein kinase domain
jaccard_groups_5743 1002.86 +- 0.00 2 0 2 0 0.02 +- 0.01 2 11

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF03466 (2/2) LysR substrate binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00664 (2/2) ABC transporter transmembrane region
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
jaccard_groups_818 83.45 +- 71.35 2 0 0 0 0.09 +- 0.16 2 3

PF00135 (2/2) Carboxylesterase family
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09084 (1/2) NMT1/THI5 like
jaccard_groups_5746 294.91 +- 210.65 2 0 2 0 0.04 +- 0.05 2 7

PF02638 (2/2) Glycosyl hydrolase-like 10
PF01471 (2/2) Putative peptidoglycan binding domain
PF00494 (2/2) Squalene/phytoene synthase
PF00348 (2/2) Polyprenyl synthetase
PF00005 (2/2) ABC transporter
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
jaccard_groups_810 16.57 +- 5.45 3 0 0 0 0.20 +- 0.38 3 4

TIGR00485 (3/3) translation elongation factor Tu
PF03144 (3/3) Elongation factor Tu domain 2
PF03143 (3/3) Elongation factor Tu C-terminal domain
PF00009 (3/3) Elongation factor Tu GTP binding domain
jaccard_groups_817 13.82 +- 7.96 40 0 0 0 0.19 +- 0.10 40 5

TIGR03801 (40/40) aspartate 4-decarboxylase
PF00155 (40/40) Aminotransferase class I and II
TIGR03802 (39/40) aspartate-alanine antiporter
PF06826 (39/40) Predicted Permease Membrane Region
PF02080 (39/40) TrkA-C domain
jaccard_groups_815 104.51 +- 133.25 6 0 5 0 0.12 +- 0.25 6 6

PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF04030 (6/6) D-arabinono-1,4-lactone oxidase
PF01565 (6/6) FAD binding domain
PF01522 (6/6) Polysaccharide deacetylase
PF00248 (5/6) Aldo/keto reductase family
PF00106 (5/6) short chain dehydrogenase
jaccard_groups_814 68.44 +- 65.20 7 0 3 0 0.07 +- 0.12 7 3

PF17189 (6/7) Glycosyl hydrolase family 30 beta sandwich domain
PF02055 (6/7) Glycosyl hydrolase family 30 TIM-barrel domain
PF00652 (6/7) Ricin-type beta-trefoil lectin domain
jaccard_groups_1088 22.09 +- 9.19 2 0 1 0 0.09 +- 0.08 2 4

PF11695 (2/2) Domain of unknown function (DUF3291)
PF12840 (1/2) Helix-turn-helix domain
PF08445 (1/2) FR47-like protein
PF00069 (1/2) Protein kinase domain
jaccard_groups_1083 16.71 +- 6.74 4 0 0 0 0.20 +- 0.26 4 4

PF10118 (4/4) Predicted metal-dependent hydrolase
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF13673 (2/4) Acetyltransferase (GNAT) domain
jaccard_groups_1080 18.19 +- 0.38 2 0 0 0 0.11 +- 0.19 2 8

TIGR00632 (2/2) DNA mismatch endonuclease Vsr
PF03852 (2/2) DNA mismatch endonuclease Vsr
PF00145 (2/2) C-5 cytosine-specific DNA methylase
PF14390 (1/2) Putative PD-(D/E)XK family member, (DUF4420)
PF10593 (1/2) Z1 domain
PF04480 (1/2) Protein of unknown function (DUF559)
PF02057 (1/2) Glycosyl hydrolase family 59
PF00383 (1/2) Cytidine and deoxycytidylate deaminase zinc-binding region
jaccard_groups_1209 113.25 +- 15.75 2 0 0 0 0.02 +- 0.01 2 4

PF07478 (2/2) D-ala D-ala ligase C-terminus
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF00583 (2/2) Acetyltransferase (GNAT) family
PF13407 (1/2) Periplasmic binding protein domain
jaccard_groups_1248 231.51 +- 124.68 37 0 37 0 0.13 +- 0.24 37 23

PF02195 (37/37) ParB-like nuclease domain
PF00668 (37/37) Condensation domain
PF00664 (37/37) ABC transporter transmembrane region
PF00501 (37/37) AMP-binding enzyme
PF00005 (37/37) ABC transporter
TIGR01733 (36/37) amino acid adenylation domain
TIGR01720 (36/37) non-ribosomal peptide synthase domain TIGR01720
PF13193 (36/37) AMP-binding enzyme C-terminal domain
PF00550 (36/37) Phosphopantetheine attachment site
TIGR01361 (33/37) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (33/37) DAHP synthase ferredoxin-like domain
PF13592 (33/37) Winged helix-turn helix
PF13551 (33/37) Winged helix-turn helix
PF13370 (33/37) 4Fe-4S single cluster domain of Ferredoxin I
PF04820 (33/37) Tryptophan halogenase
PF03621 (33/37) MbtH-like protein
PF00975 (33/37) Thioesterase domain
PF00793 (33/37) DAHP synthetase I family
PF00196 (33/37) Bacterial regulatory proteins, luxR family
PF00067 (33/37) Cytochrome P450
PF00999 (32/37) Sodium/hydrogen exchanger family
PF13191 (29/37) AAA ATPase domain
PF13649 (19/37) Methyltransferase domain
jaccard_groups_4750 32.61 +- 14.46 3 0 0 0 0.20 +- 0.26 3 8

TIGR00369 (3/3) uncharacterized domain 1
PF03061 (3/3) Thioesterase superfamily
PF01872 (3/3) RibD C-terminal domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00067 (3/3) Cytochrome P450
PF07730 (2/3) Histidine kinase
PF00892 (2/3) EamA-like transporter family
PF00072 (2/3) Response regulator receiver domain
jaccard_groups_1240 111.53 +- 30.28 2 0 0 0 0.05 +- 0.07 2 5

PF00583 (2/2) Acetyltransferase (GNAT) family
PF08877 (1/2) MepB protein
PF00561 (1/2) alpha/beta hydrolase fold
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_1717 113.27 +- 14.45 28 0 28 0 0.10 +- 0.23 28 15

PF13822 (28/28) Acyl-CoA carboxylase epsilon subunit
PF08031 (28/28) Berberine and berberine like
PF01648 (28/28) 4'-phosphopantetheinyl transferase superfamily
PF01565 (28/28) FAD binding domain
PF01494 (28/28) FAD binding domain
PF01039 (28/28) Carboxyl transferase domain
PF00583 (28/28) Acetyltransferase (GNAT) family
PF13561 (27/28) Enoyl-(Acyl carrier protein) reductase
PF13459 (27/28) 4Fe-4S single cluster domain
PF10604 (27/28) Polyketide cyclase / dehydrase and lipid transport
PF03704 (27/28) Bacterial transcriptional activator domain
PF00975 (27/28) Thioesterase domain
PF00550 (27/28) Phosphopantetheine attachment site
PF00486 (27/28) Transcriptional regulatory protein, C terminal
PF00067 (27/28) Cytochrome P450
jaccard_groups_1714 152.56 +- 17.27 4 0 0 0 0.03 +- 0.05 4 7

PF00293 (4/4) NUDIX domain
TIGR04364 (3/4) methyltransferase, FxLD system
PF08242 (3/4) Methyltransferase domain
PF07690 (3/4) Major Facilitator Superfamily
PF02585 (3/4) GlcNAc-PI de-N-acetylase
PF01135 (3/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/4) Acetyltransferase (GNAT) family
jaccard_groups_1243 191.74 +- 15.84 2 0 2 0 0.07 +- 0.21 2 12

PF07883 (2/2) Cupin domain
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF16864 (1/2) Dimerisation domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08592 (1/2) Domain of unknown function (DUF1772)
PF00891 (1/2) O-methyltransferase domain
jaccard_groups_1244 64.76 +- 3.28 2 0 1 0 0.23 +- 0.22 2 18

TIGR00839 (2/2) aspartate ammonia-lyase
PF10415 (2/2) Fumarase C C-terminus
PF07729 (2/2) FCD domain
PF06089 (2/2) L-asparaginase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF00206 (2/2) Lyase
PF18631 (1/2) Cucumopine synthase C-terminal helical bundle domain
PF17203 (1/2) Single cache domain 3
PF14689 (1/2) Sensor_kinase_SpoOB-type, alpha-helical domain
PF09339 (1/2) IclR helix-turn-helix domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01266 (1/2) FAD dependent oxidoreductase
PF00989 (1/2) PAS fold
PF00501 (1/2) AMP-binding enzyme
PF00171 (1/2) Aldehyde dehydrogenase family
PF00072 (1/2) Response regulator receiver domain
jaccard_groups_1247 269.57 +- 243.84 7 0 1 1 0.05 +- 0.08 7 3

PF00753 (7/7) Metallo-beta-lactamase superfamily
PF07690 (5/7) Major Facilitator Superfamily
PF02615 (4/7) Malate/L-lactate dehydrogenase
jaccard_groups_105 75.18 +- 80.54 54 0 0 1 0.08 +- 0.10 54 3

PF04464 (54/54) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (54/54) Glycosyl transferase family 2
PF00534 (37/54) Glycosyl transferases group 1
jaccard_groups_1887 54.75 +- 15.10 3 0 0 0 0.10 +- 0.09 3 8

TIGR00072 (3/3) hydrogenase maturation protease
PF17179 (3/3) 4Fe-4S dicluster domain
PF10418 (3/3) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (3/3) Hydrogenase maturation protease
PF01058 (3/3) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (3/3) Nickel-dependent hydrogenase
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00027 (3/3) Cyclic nucleotide-binding domain
jaccard_groups_107 51.81 +- 23.08 9 0 0 2 0.06 +- 0.06 9 2

PF12833 (9/9) Helix-turn-helix domain
PF12852 (6/9) Cupin
jaccard_groups_3560 343.25 +- 234.94 6 0 0 0 0.02 +- 0.03 6 10

PF14100 (6/6) Methane oxygenase PmoA
PF13377 (6/6) Periplasmic binding protein-like domain
PF13338 (6/6) Transcriptional regulator, AbiEi antitoxin
PF07883 (6/6) Cupin domain
PF02894 (6/6) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (6/6) Oxidoreductase family, NAD-binding Rossmann fold
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF16349 (5/6) Domain of unknown function (DUF4978)
PF14200 (5/6) Ricin-type beta-trefoil lectin domain-like
PF04616 (3/6) Glycosyl hydrolases family 43
jaccard_groups_100 365.43 +- 398.12 16 0 0 0 0.09 +- 0.21 16 2

PF17964 (16/16) Bacterial Ig domain
PF03734 (16/16) L,D-transpeptidase catalytic domain
jaccard_groups_1880 51.82 +- 23.00 4 0 2 0 0.19 +- 0.30 4 9

TIGR03571 (4/4) luciferase-type oxidoreductase, BA3436 family
PF03928 (4/4) Haem-degrading
PF00296 (4/4) Luciferase-like monooxygenase
PF00248 (4/4) Aldo/keto reductase family
PF12680 (3/4) SnoaL-like domain
PF10604 (3/4) Polyketide cyclase / dehydrase and lipid transport
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/4) Major Facilitator Superfamily
PF00857 (2/4) Isochorismatase family
jaccard_groups_102 145.62 +- 238.29 80 0 60 8 0.18 +- 0.25 80 6

TIGR03797 (80/80) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (80/80) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF03412 (80/80) Peptidase C39 family
PF00664 (80/80) ABC transporter transmembrane region
PF00005 (80/80) ABC transporter
PF13437 (74/80) HlyD family secretion protein
jaccard_groups_3567 33.12 +- 2.47 2 0 0 0 0.20 +- 0.25 2 10

TIGR00198 (2/2) catalase/peroxidase HPI
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03777 (2/2) ChpA-C
PF02515 (2/2) CoA-transferase family III
PF01475 (2/2) Ferric uptake regulator family
PF00561 (2/2) alpha/beta hydrolase fold
PF00501 (2/2) AMP-binding enzyme
PF00141 (2/2) Peroxidase
PF00069 (2/2) Protein kinase domain
PF03358 (1/2) NADPH-dependent FMN reductase
jaccard_groups_3564 82.12 +- 28.60 3 0 3 0 0.08 +- 0.04 3 13

PF16901 (3/3) C-terminal domain of alpha-glycerophosphate oxidase
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (3/3) FAD binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00083 (3/3) Sugar (and other) transporter
PF10604 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF04978 (2/3) Protein of unknown function (DUF664)
PF04655 (2/3) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04309 (2/3) Glycerol-3-phosphate responsive antiterminator
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_4106 1560.00 +- 457.32 4 0 0 0 0.01 +- 0.00 4 21

PF16353 (4/4) Domain of unknown function(DUF4981)
PF13378 (4/4) Enolase C-terminal domain-like
PF13377 (4/4) Periplasmic binding protein-like domain
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF01370 (3/4) NAD dependent epimerase/dehydratase family
TIGR01182 (2/4) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
PF06452 (2/4) Carbohydrate family 9 binding domain-like
PF02826 (2/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02065 (2/4) Melibiase
PF01081 (2/4) KDPG and KHG aldolase
PF00703 (2/4) Glycosyl hydrolases family 2
PF00294 (2/4) pfkB family carbohydrate kinase
PF00107 (2/4) Zinc-binding dehydrogenase
jaccard_groups_4107 64.63 +- 1.33 2 0 0 0 0.16 +- 0.14 2 13

PF16990 (2/2) Carbohydrate binding module (family 35)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF01204 (2/2) Trehalase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13377 (1/2) Periplasmic binding protein-like domain
PF13229 (1/2) Right handed beta helix region
PF08281 (1/2) Sigma-70, region 4
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03664 (1/2) Glycosyl hydrolase family 62
PF00754 (1/2) F5/8 type C domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00331 (1/2) Glycosyl hydrolase family 10
jaccard_groups_4101 275.73 +- 48.75 4 0 0 0 0.03 +- 0.03 4 12

PF13977 (4/4) BetI-type transcriptional repressor, C-terminal
PF13607 (4/4) Succinyl-CoA ligase like flavodoxin domain
PF13549 (4/4) ATP-grasp domain
PF13380 (4/4) CoA binding domain
PF13279 (4/4) Thioesterase-like superfamily
PF07729 (4/4) FCD domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_3603 104.94 +- 26.55 4 0 1 0 0.03 +- 0.03 4 4

TIGR00087 (4/4) 5'/3'-nucleotidase SurE
PF07690 (4/4) Major Facilitator Superfamily
PF01975 (4/4) Survival protein SurE
PF00135 (4/4) Carboxylesterase family
jaccard_groups_1408 70.03 +- 42.29 7 0 0 0 0.17 +- 0.21 7 7

PF13561 (6/7) Enoyl-(Acyl carrier protein) reductase
PF13378 (6/7) Enolase C-terminal domain-like
PF04909 (6/7) Amidohydrolase
PF02746 (6/7) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00248 (6/7) Aldo/keto reductase family
PF05336 (5/7) L-rhamnose mutarotase
PF01557 (4/7) Fumarylacetoacetate (FAA) hydrolase family
jaccard_groups_1409 292.29 +- 149.60 7 0 2 7 0.02 +- 0.02 7 4

PF04055 (7/7) Radical SAM superfamily
PF02223 (7/7) Thymidylate kinase
PF00293 (6/7) NUDIX domain
PF02310 (4/7) B12 binding domain
jaccard_groups_3804 698.76 +- 460.13 3 0 0 0 0.02 +- 0.03 3 8

PF10502 (3/3) Signal peptidase, peptidase S26
PF03704 (3/3) Bacterial transcriptional activator domain
PF00931 (3/3) NB-ARC domain
PF00717 (3/3) Peptidase S24-like
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
PF07291 (2/3) Methylamine utilisation protein MauE
PF00899 (2/3) ThiF family
jaccard_groups_3807 641.57 +- 232.29 3 0 0 0 0.02 +- 0.01 3 5

PF16875 (3/3) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (3/3) Glycosyl hydrolase family 36 C-terminal domain
PF02065 (3/3) Melibiase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4329 39.54 +- 16.14 3 0 0 0 0.12 +- 0.21 3 8

TIGR04186 (3/3) putative ATP-grasp target RiPP
PF14404 (3/3) Ribosomally synthesized peptide in Streptomyces species
PF13449 (3/3) Esterase-like activity of phytase
PF12796 (3/3) Ankyrin repeats (3 copies)
PF08031 (3/3) Berberine and berberine like
PF07690 (3/3) Major Facilitator Superfamily
PF01565 (3/3) FAD binding domain
PF00067 (3/3) Cytochrome P450
jaccard_groups_4324 156.91 +- 128.46 4 0 4 0 0.05 +- 0.11 4 5

PF13649 (4/4) Methyltransferase domain
PF06276 (4/4) Ferric iron reductase FhuF-like transporter
PF04183 (4/4) IucA / IucC family
PF18616 (2/4) CDI immunity proteins
PF18029 (2/4) Glyoxalase-like domain
jaccard_groups_4325 64.36 +- 29.46 2 0 0 0 0.16 +- 0.31 2 10

TIGR01788 (2/2) glutamate decarboxylase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13560 (2/2) Helix-turn-helix domain
PF13365 (2/2) Trypsin-like peptidase domain
PF10901 (2/2) Protein of unknown function (DUF2690)
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
jaccard_groups_4326 34.25 +- 15.69 2 0 0 0 0.15 +- 0.31 2 10

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF02872 (2/2) 5'-nucleotidase, C-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
TIGR00838 (1/2) argininosuccinate lyase
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF04343 (1/2) Protein of unknown function, DUF488
PF00206 (1/2) Lyase
jaccard_groups_4327 217.10 +- 169.90 2 0 0 0 0.04 +- 0.10 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00912 (1/2) Transglycosylase
jaccard_groups_1062 385.76 +- 314.07 44 0 31 9 0.04 +- 0.14 44 7

PF00501 (44/44) AMP-binding enzyme
PF00550 (41/44) Phosphopantetheine attachment site
PF00441 (41/44) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (40/44) Acyl-CoA dehydrogenase, middle domain
PF13193 (39/44) AMP-binding enzyme C-terminal domain
PF02771 (37/44) Acyl-CoA dehydrogenase, N-terminal domain
TIGR01733 (36/44) amino acid adenylation domain
jaccard_groups_1063 14.11 +- 0.89 2 0 0 0 0.14 +- 0.19 2 2

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
jaccard_groups_1065 101.45 +- 54.55 2 0 1 0 0.03 +- 0.03 2 8

PF13462 (2/2) Thioredoxin
PF06965 (2/2) Na+/H+ antiporter 1
TIGR00773 (1/2) Na+/H+ antiporter NhaA
PF10944 (1/2) Protein of unknown function (DUF2630)
PF07690 (1/2) Major Facilitator Superfamily
PF02308 (1/2) MgtC family
PF00248 (1/2) Aldo/keto reductase family
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_1068 218.51 +- 223.57 59 0 10 0 0.07 +- 0.07 59 13

TIGR01850 (59/59) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (59/59) alpha-L-glutamate ligase, RimK family
PF08443 (59/59) RimK-like ATP-grasp domain
PF02812 (59/59) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (59/59) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (59/59) Amino acid kinase family
PF00682 (59/59) HMGL-like
PF00501 (59/59) AMP-binding enzyme
PF00208 (59/59) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00117 (59/59) Glutamine amidotransferase class-I
PF13193 (58/59) AMP-binding enzyme C-terminal domain
PF00155 (51/59) Aminotransferase class I and II
PF02774 (37/59) Semialdehyde dehydrogenase, dimerisation domain
jaccard_groups_4744 548.43 +- 376.03 3 0 1 0 0.06 +- 0.14 3 11

PF11175 (3/3) Protein of unknown function (DUF2961)
PF07882 (3/3) L-fucose isomerase, second N-terminal domain
PF07881 (3/3) L-fucose isomerase, first N-terminal domain
PF02952 (3/3) L-fucose isomerase, C-terminal domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF13407 (2/3) Periplasmic binding protein domain
PF02653 (2/3) Branched-chain amino acid transport system / permease component
PF00005 (2/3) ABC transporter
jaccard_groups_4742 2825.68 +- 2800.07 3 0 3 2 0.08 +- 0.23 3 16

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12679 (3/3) ABC-2 family transporter protein
PF08241 (3/3) Methyltransferase domain
PF07730 (3/3) Histidine kinase
PF06722 (3/3) Protein of unknown function (DUF1205)
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
PF00733 (2/3) Asparagine synthase
jaccard_groups_4743 226.75 +- 33.25 2 0 0 0 0.01 +- 0.00 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13365 (2/2) Trypsin-like peptidase domain
PF13191 (2/2) AAA ATPase domain
PF10503 (2/2) Esterase PHB depolymerase
PF00400 (2/2) WD domain, G-beta repeat
jaccard_groups_1663 22.13 +- 7.67 3 0 0 0 0.19 +- 0.15 3 8

TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF04476 (3/3) 4-HFC-P synthase
PF04072 (3/3) Leucine carboxyl methyltransferase
PF00171 (3/3) Aldehyde dehydrogenase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF18029 (2/3) Glyoxalase-like domain
PF16116 (2/3) Domain of unknown function (DUF4832)
jaccard_groups_1668 24.83 +- 3.79 2 0 2 0 0.24 +- 0.35 2 7

PF07994 (2/2) Myo-inositol-1-phosphate synthase
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01040 (2/2) UbiA prenyltransferase family
PF01026 (2/2) TatD related DNase
PF01494 (1/2) FAD binding domain
PF01212 (1/2) Beta-eliminating lyase
jaccard_groups_1669 103.97 +- 170.68 19 0 2 0 0.10 +- 0.11 19 5

PF02782 (19/19) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (19/19) FGGY family of carbohydrate kinases, N-terminal domain
PF08220 (18/19) DeoR-like helix-turn-helix domain
PF00455 (18/19) DeoR C terminal sensor domain
PF00300 (13/19) Histidine phosphatase superfamily (branch 1)
jaccard_groups_4926 245.78 +- 157.19 3 0 0 0 0.08 +- 0.16 3 22

TIGR01552 (3/3) prevent-host-death family protein
TIGR00663 (3/3) DNA polymerase III, beta subunit
PF08031 (3/3) Berberine and berberine like
PF07690 (3/3) Major Facilitator Superfamily
PF05016 (3/3) ParE toxin of type II toxin-antitoxin system, parDE
PF04073 (3/3) Aminoacyl-tRNA editing domain
PF02768 (3/3) DNA polymerase III beta subunit, C-terminal domain
PF02767 (3/3) DNA polymerase III beta subunit, central domain
PF02604 (3/3) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02274 (3/3) Amidinotransferase
PF01565 (3/3) FAD binding domain
PF00712 (3/3) DNA polymerase III beta subunit, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
TIGR00348 (2/3) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/3) SWI2/SNF2 ATPase
PF13476 (2/3) AAA domain
PF13304 (2/3) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (2/3) HsdM N-terminal domain
PF11867 (2/3) Domain of unknown function (DUF3387)
PF04313 (2/3) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/3) N-6 DNA Methylase
PF01420 (2/3) Type I restriction modification DNA specificity domain
jaccard_groups_4924 365.53 +- 135.74 3 0 0 0 0.02 +- 0.01 3 9

PF13602 (3/3) Zinc-binding dehydrogenase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02515 (3/3) CoA-transferase family III
PF00561 (3/3) alpha/beta hydrolase fold
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF12697 (2/3) Alpha/beta hydrolase family
PF09339 (2/3) IclR helix-turn-helix domain
PF01614 (2/3) Bacterial transcriptional regulator
jaccard_groups_4259 342.42 +- 48.47 3 0 0 0 0.02 +- 0.01 3 6

PF18631 (3/3) Cucumopine synthase C-terminal helical bundle domain
PF13546 (3/3) DDE superfamily endonuclease
PF02195 (3/3) ParB-like nuclease domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_4929 355.83 +- 229.17 2 0 0 0 0.03 +- 0.04 2 11

TIGR01296 (2/2) aspartate-semialdehyde dehydrogenase
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03466 (2/2) LysR substrate binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/2) B12 binding domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00892 (2/2) EamA-like transporter family
PF00696 (2/2) Amino acid kinase family
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_4632 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_4631 69.92 +- 47.28 3 0 0 0 0.14 +- 0.15 3 7

PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF03466 (3/3) LysR substrate binding domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF17801 (2/3) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/3) Alpha galactosidase A
PF03664 (2/3) Glycosyl hydrolase family 62
jaccard_groups_4636 87.56 +- 21.14 3 0 0 0 0.04 +- 0.01 3 6

TIGR03356 (3/3) beta-galactosidase
PF08329 (3/3) Chitinase A, N-terminal domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00376 (3/3) MerR family regulatory protein
PF00331 (3/3) Glycosyl hydrolase family 10
PF00232 (3/3) Glycosyl hydrolase family 1
jaccard_groups_4638 153.77 +- 41.89 3 0 1 0 0.11 +- 0.24 3 12

PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (3/3) ABC transporter
TIGR03841 (2/3) probable F420-dependent oxidoreductase, Rv3093c family
PF00496 (2/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00294 (2/3) pfkB family carbohydrate kinase
jaccard_groups_3938 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
jaccard_groups_3930 303.36 +- 159.73 3 0 0 0 0.06 +- 0.08 3 13

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF12911 (3/3) N-terminal TM domain of oligopeptide transport permease C
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00005 (3/3) ABC transporter
TIGR00976 (2/3) hydrolase CocE/NonD family protein
TIGR00026 (2/3) deazaflavin-dependent oxidoreductase, nitroreductase family
PF08530 (2/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (2/3) Major Facilitator Superfamily
PF04075 (2/3) F420H(2)-dependent quinone reductase
PF02129 (2/3) X-Pro dipeptidyl-peptidase (S15 family)
jaccard_groups_324 72.41 +- 62.39 257 0 41 257 0.17 +- 0.11 257 8

PF08530 (257/257) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (257/257) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00005 (257/257) ABC transporter
TIGR00976 (256/257) hydrolase CocE/NonD family protein
PF02129 (256/257) X-Pro dipeptidyl-peptidase (S15 family)
PF01032 (253/257) FecCD transport family
PF01497 (250/257) Periplasmic binding protein
PF00664 (229/257) ABC transporter transmembrane region
jaccard_groups_3932 109.46 +- 5.44 5 0 0 0 0.12 +- 0.30 5 11

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (5/5) argininosuccinate lyase
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF03972 (5/5) MmgE/PrpD family
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01522 (5/5) Polysaccharide deacetylase
PF00596 (5/5) Class II Aldolase and Adducin N-terminal domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
jaccard_groups_3933 384.03 +- 260.06 4 0 1 0 0.04 +- 0.16 4 13

TIGR02348 (4/4) chaperonin GroL
TIGR01197 (4/4) metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF04909 (4/4) Amidohydrolase
PF02406 (4/4) MmoB/DmpM family
PF02332 (4/4) Methane/Phenol/Toluene Hydroxylase
PF01883 (4/4) Iron-sulfur cluster assembly protein
PF01566 (4/4) Natural resistance-associated macrophage protein
PF00970 (4/4) Oxidoreductase FAD-binding domain
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00118 (4/4) TCP-1/cpn60 chaperonin family
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (4/4) Zinc-binding dehydrogenase
jaccard_groups_320 166.73 +- 208.23 20 0 4 20 0.08 +- 0.19 20 5

PF01135 (20/20) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
TIGR04188 (19/20) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (19/20) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (19/20) putative ATP-grasp target RiPP
PF14408 (18/20) Ribosomally synthesised peptide in actinomycetes
jaccard_groups_3936 356.58 +- 209.63 4 0 3 0 0.03 +- 0.06 4 6

PF17827 (4/4) PrmC N-terminal domain
PF13649 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01266 (4/4) FAD dependent oxidoreductase
PF00440 (3/4) Bacterial regulatory proteins, tetR family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
jaccard_groups_2998 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
jaccard_groups_4818 1278.10 +- 1285.56 3 0 1 0 0.01 +- 0.00 3 11

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (3/3) amino acid adenylation domain
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00720 (2/3) Subtilisin inhibitor-like
PF00144 (2/3) Beta-lactamase
jaccard_groups_2995 183.48 +- 172.19 8 0 0 0 0.03 +- 0.02 8 3

PF07883 (8/8) Cupin domain
PF02826 (8/8) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (8/8) Phosphotransferase enzyme family
jaccard_groups_2997 66.06 +- 37.25 9 0 0 0 0.06 +- 0.06 9 5

PF13563 (9/9) 2'-5' RNA ligase superfamily
PF07690 (9/9) Major Facilitator Superfamily
PF06831 (9/9) Formamidopyrimidine-DNA glycosylase H2TH domain
PF01243 (9/9) Pyridoxamine 5'-phosphate oxidase
PF01149 (9/9) Formamidopyrimidine-DNA glycosylase N-terminal domain
jaccard_groups_4815 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
jaccard_groups_6277 206.27 +- 183.73 2 0 2 0 0.07 +- 0.20 2 6

PF18765 (2/2) Polymerase beta, Nucleotidyltransferase
PF06236 (2/2) Tyrosinase co-factor MelC1
PF00296 (2/2) Luciferase-like monooxygenase
PF00293 (2/2) NUDIX domain
PF00264 (2/2) Common central domain of tyrosinase
PF13228 (1/2) Domain of unknown function (DUF4037)
jaccard_groups_3246 172.18 +- 31.32 7 0 0 0 0.06 +- 0.09 7 10

PF13377 (7/7) Periplasmic binding protein-like domain
PF12697 (7/7) Alpha/beta hydrolase family
PF01547 (7/7) Bacterial extracellular solute-binding protein
PF01238 (7/7) Phosphomannose isomerase type I
PF00703 (7/7) Glycosyl hydrolases family 2
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00356 (7/7) Bacterial regulatory proteins, lacI family
TIGR00218 (6/7) mannose-6-phosphate isomerase, class I
PF03425 (5/7) Carbohydrate binding domain (family 11)
PF13205 (4/7) Bacterial Ig-like domain
jaccard_groups_250 64.89 +- 51.36 5 0 1 0 0.08 +- 0.15 5 5

PF01497 (5/5) Periplasmic binding protein
PF01032 (5/5) FecCD transport family
PF00005 (5/5) ABC transporter
PF11575 (3/5) FhuF 2Fe-2S C-terminal domain
PF08241 (3/5) Methyltransferase domain
jaccard_groups_257 35.46 +- 16.85 6 0 0 0 0.10 +- 0.12 6 6

TIGR01552 (6/6) prevent-host-death family protein
PF02604 (6/6) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01850 (4/6) PIN domain
PF12277 (3/6) Protein of unknown function (DUF3618)
PF07332 (3/6) Putative Actinobacterial Holin-X, holin superfamily III
PF00903 (3/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_259 91.22 +- 81.78 7 0 0 0 0.05 +- 0.06 7 2

PF00571 (7/7) CBS domain
PF04972 (6/7) BON domain
jaccard_groups_4247 748.34 +- 222.70 4 0 1 0 0.01 +- 0.01 4 9

PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF03795 (4/4) YCII-related domain
PF03321 (4/4) GH3 auxin-responsive promoter
PF01613 (4/4) Flavin reductase like domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00155 (4/4) Aminotransferase class I and II
jaccard_groups_4936 32.35 +- 0.21 3 0 0 0 0.14 +- 0.21 3 8

PF13581 (3/3) Histidine kinase-like ATPase domain
PF13305 (3/3) Tetracyclin repressor-like, C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF00294 (3/3) pfkB family carbohydrate kinase
PF00149 (3/3) Calcineurin-like phosphoesterase
TIGR01695 (2/3) murein biosynthesis integral membrane protein MurJ
PF03023 (2/3) Lipid II flippase MurJ
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_2191 25.37 +- 4.78 2 0 1 0 0.14 +- 0.13 2 6

PF09335 (2/2) SNARE associated Golgi protein
PF00248 (2/2) Aldo/keto reductase family
TIGR03395 (1/2) sphingomyelin phosphodiesterase
PF13581 (1/2) Histidine kinase-like ATPase domain
PF05532 (1/2) CsbD-like
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
jaccard_groups_2193 229.33 +- 157.67 2 0 1 0 0.05 +- 0.07 2 7

TIGR01221 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00535 (2/2) Glycosyl transferase family 2
PF07690 (1/2) Major Facilitator Superfamily
PF04464 (1/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF01047 (1/2) MarR family
PF00857 (1/2) Isochorismatase family
jaccard_groups_2197 74.57 +- 95.28 12 0 12 12 0.10 +- 0.25 12 19

TIGR03891 (12/12) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (12/12) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (12/12) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01733 (12/12) amino acid adenylation domain
PF16197 (12/12) Ketoacyl-synthetase C-terminal extension
PF14028 (12/12) Lantibiotic biosynthesis dehydratase C-term
PF13193 (12/12) AMP-binding enzyme C-terminal domain
PF08659 (12/12) KR domain
PF02801 (12/12) Beta-ketoacyl synthase, C-terminal domain
PF02624 (12/12) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/12) Nitroreductase family
PF00698 (12/12) Acyl transferase domain
PF00668 (12/12) Condensation domain
PF00550 (12/12) Phosphopantetheine attachment site
PF00501 (12/12) AMP-binding enzyme
PF00109 (12/12) Beta-ketoacyl synthase, N-terminal domain
PF03992 (11/12) Antibiotic biosynthesis monooxygenase
PF00575 (10/12) S1 RNA binding domain
PF04738 (8/12) Lantibiotic dehydratase, N terminus
jaccard_groups_3112 179.59 +- 75.27 4 0 0 0 0.03 +- 0.01 4 8

PF00970 (4/4) Oxidoreductase FAD-binding domain
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF13450 (3/4) NAD(P)-binding Rossmann-like domain
PF07690 (3/4) Major Facilitator Superfamily
jaccard_groups_3111 305.66 +- 186.24 7 0 6 0 0.07 +- 0.21 7 8

TIGR01181 (7/7) dTDP-glucose 4,6-dehydratase
PF17755 (7/7) UvrA DNA-binding domain
PF16363 (7/7) GDP-mannose 4,6 dehydratase
PF13460 (7/7) NAD(P)H-binding
PF05368 (7/7) NmrA-like family
PF03992 (7/7) Antibiotic biosynthesis monooxygenase
PF03559 (7/7) NDP-hexose 2,3-dehydratase
PF00005 (7/7) ABC transporter
jaccard_groups_6411 322.50 +- 223.27 2 0 2 0 0.06 +- 0.21 2 18

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01035 (2/2) glutamyl-tRNA reductase
PF17645 (2/2) Arylmalonate decarboxylase
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13549 (2/2) ATP-grasp domain
PF13380 (2/2) CoA binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF05201 (2/2) Glutamyl-tRNAGlu reductase, N-terminal domain
PF03795 (2/2) YCII-related domain
PF03466 (2/2) LysR substrate binding domain
PF01494 (2/2) FAD binding domain
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00892 (2/2) EamA-like transporter family
PF00745 (2/2) Glutamyl-tRNAGlu reductase, dimerisation domain
PF00490 (2/2) Delta-aminolevulinic acid dehydratase
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3114 22.83 +- 8.56 3 0 0 0 0.13 +- 0.08 3 3

PF03483 (3/3) B3/4 domain
PF04299 (2/3) Putative FMN-binding domain
PF00892 (2/3) EamA-like transporter family
jaccard_groups_6413 352.88 +- 167.12 2 0 2 2 0.02 +- 0.03 2 8

TIGR00702 (2/2) YcaO-type kinase domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF07812 (2/2) TfuA-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02543 (2/2) Carbamoyltransferase N-terminus
PF12802 (1/2) MarR family
jaccard_groups_3026 31.31 +- 4.15 2 0 0 0 0.13 +- 0.19 2 10

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/2) Alpha galactosidase A
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00348 (2/2) Polyprenyl synthetase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00144 (2/2) Beta-lactamase
PF12972 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF05089 (1/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
jaccard_groups_3027 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
jaccard_groups_3025 73.10 +- 13.56 2 0 0 0 0.03 +- 0.03 2 2

PF01613 (2/2) Flavin reductase like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_3022 315.50 +- 100.50 2 0 0 0 0.01 +- 0.01 2 12

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00589 (2/2) methylated-DNA--[protein]-cysteine S-methyltransferase
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02870 (2/2) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
TIGR02777 (1/2) DNA ligase D, 3'-phosphoesterase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13298 (1/2) DNA polymerase Ligase (LigD)
PF08031 (1/2) Berberine and berberine like
PF02805 (1/2) Metal binding domain of Ada
PF01565 (1/2) FAD binding domain
jaccard_groups_3023 311.48 +- 131.93 7 0 1 0 0.06 +- 0.21 7 6

PF02803 (7/7) Thiolase, C-terminal domain
PF00501 (7/7) AMP-binding enzyme
PF00108 (7/7) Thiolase, N-terminal domain
PF13193 (6/7) AMP-binding enzyme C-terminal domain
PF07690 (6/7) Major Facilitator Superfamily
PF13556 (5/7) PucR C-terminal helix-turn-helix domain
jaccard_groups_3021 52.56 +- 3.75 3 0 0 0 0.08 +- 0.08 3 5

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF10990 (3/3) Protein of unknown function (DUF2809)
PF07681 (3/3) DoxX
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
jaccard_groups_6077 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
jaccard_groups_3028 278.57 +- 111.43 2 0 1 0 0.01 +- 0.01 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF01266 (2/2) FAD dependent oxidoreductase
TIGR03364 (1/2) FAD dependent oxidoreductase TIGR03364
TIGR02335 (1/2) phosphonoacetate hydrolase
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF01663 (1/2) Type I phosphodiesterase / nucleotide pyrophosphatase
jaccard_groups_1482 89.44 +- 44.24 9 0 4 2 0.13 +- 0.12 9 13

PF16861 (9/9) Carbamoyltransferase C-terminus
PF13580 (9/9) SIS domain
PF13439 (9/9) Glycosyltransferase Family 4
PF13242 (9/9) HAD-hyrolase-like
PF02543 (9/9) Carbamoyltransferase N-terminus
PF01075 (9/9) Glycosyltransferase family 9 (heptosyltransferase)
PF00534 (9/9) Glycosyl transferases group 1
PF01467 (8/9) Cytidylyltransferase-like
PF01370 (8/9) NAD dependent epimerase/dehydratase family
PF00535 (8/9) Glycosyl transferase family 2
PF00294 (8/9) pfkB family carbohydrate kinase
TIGR02199 (6/9) bifunctional protein RfaE, domain II
TIGR01662 (6/9) HAD hydrolase, family IIIA
jaccard_groups_647 60.69 +- 67.32 21 0 0 0 0.16 +- 0.21 21 6

PF00294 (19/21) pfkB family carbohydrate kinase
PF13378 (18/21) Enolase C-terminal domain-like
PF02746 (18/21) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
TIGR02605 (12/21) putative regulatory protein, FmdB family
PF09723 (12/21) Zinc ribbon domain
PF14325 (11/21) Domain of unknown function (DUF4383)
jaccard_groups_642 303.86 +- 416.59 132 0 6 0 0.04 +- 0.06 132 7

TIGR03919 (132/132) type VII secretion protein EccB
PF05108 (132/132) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (127/132) type VII secretion integral membrane protein EccD
PF08817 (125/132) WXG100 protein secretion system (Wss), protein YukD
PF02575 (116/132) YbaB/EbfC DNA-binding family
PF06013 (109/132) Proteins of 100 residues with WXG
TIGR03930 (103/132) WXG100 family type VII secretion target
jaccard_groups_3759 88.53 +- 21.64 4 0 0 0 0.02 +- 0.03 4 3

PF06259 (4/4) Alpha/beta hydrolase
PF04149 (4/4) Domain of unknown function (DUF397)
PF01810 (4/4) LysE type translocator
jaccard_groups_4985 229.59 +- 202.28 2 0 0 0 0.09 +- 0.23 2 11

TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF17967 (2/2) Pullulanase N2 domain
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF03714 (2/2) Bacterial pullanase-associated domain
PF00483 (2/2) Nucleotidyl transferase
PF00128 (2/2) Alpha amylase, catalytic domain
PF02806 (1/2) Alpha amylase, C-terminal all-beta domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00686 (1/2) Starch binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_6099 56.00 +- 0.39 2 0 2 0 0.14 +- 0.14 2 16

TIGR02353 (2/2) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (2/2) amino acid adenylation domain
TIGR01350 (2/2) dihydrolipoyl dehydrogenase
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13578 (2/2) Methyltransferase domain
PF13520 (2/2) Amino acid permease
PF10009 (2/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF09557 (2/2) Domain of unknown function (DUF2382)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05239 (2/2) PRC-barrel domain
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01433 (2/2) Peptidase family M1 domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF04239 (1/2) Protein of unknown function (DUF421)
jaccard_groups_3756 167.07 +- 63.41 3 0 0 0 0.04 +- 0.04 3 3

PF01872 (3/3) RibD C-terminal domain
PF08241 (2/3) Methyltransferase domain
PF07883 (2/3) Cupin domain
jaccard_groups_4172 79.06 +- 52.46 4 0 4 0 0.17 +- 0.25 4 19

PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF14016 (4/4) Protein of unknown function (DUF4232)
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08659 (4/4) KR domain
PF08223 (4/4) PaaX-like protein C-terminal domain
PF07848 (4/4) PaaX-like protein
PF07690 (4/4) Major Facilitator Superfamily
PF04820 (4/4) Tryptophan halogenase
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13203 (2/4) Putative metallopeptidase domain
PF09967 (2/4) VWA-like domain (DUF2201)
PF07728 (2/4) AAA domain (dynein-related subfamily)
PF00534 (2/4) Glycosyl transferases group 1
jaccard_groups_6301 68.82 +- 37.20 2 0 0 0 0.14 +- 0.32 2 10

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00313 (2/2) 'Cold-shock' DNA-binding domain
TIGR02258 (1/2) 2'-5' RNA ligase
PF02834 (1/2) LigT like Phosphoesterase
PF01435 (1/2) Peptidase family M48
PF00857 (1/2) Isochorismatase family
PF00204 (1/2) DNA gyrase B
jaccard_groups_6304 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 10

TIGR02320 (2/2) phosphoenolpyruvate mutase
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00348 (2/2) Polyprenyl synthetase
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
jaccard_groups_6305 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
jaccard_groups_6308 456.07 +- 52.62 2 0 0 0 0.01 +- 0.01 2 15

TIGR00364 (2/2) queuosine biosynthesis protein QueC
PF13692 (2/2) Glycosyl transferases group 1
PF13439 (2/2) Glycosyltransferase Family 4
PF13394 (2/2) 4Fe-4S single cluster domain
PF13242 (2/2) HAD-hyrolase-like
PF08889 (2/2) WbqC-like protein family
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF02739 (2/2) 5'-3' exonuclease, N-terminal resolvase-like domain
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01367 (2/2) 5'-3' exonuclease, C-terminal SAM fold
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00534 (2/2) Glycosyl transferases group 1
PF00156 (2/2) Phosphoribosyl transferase domain
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
jaccard_groups_6309 329.75 +- 121.75 2 0 2 0 0.01 +- 0.01 2 4

PF13489 (2/2) Methyltransferase domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
jaccard_groups_2973 250.81 +- 122.24 9 0 9 0 0.12 +- 0.25 9 32

TIGR01902 (9/9) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (9/9) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (9/9) amino acid adenylation domain
TIGR00768 (9/9) alpha-L-glutamate ligase, RimK family
PF18603 (9/9) L-amino acid ligase C-terminal domain 2
PF18130 (9/9) ATP-grasp N-terminal domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF14765 (9/9) Polyketide synthase dehydratase
PF13602 (9/9) Zinc-binding dehydrogenase
PF13535 (9/9) ATP-grasp domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF08990 (9/9) Erythronolide synthase docking
PF08659 (9/9) KR domain
PF08443 (9/9) RimK-like ATP-grasp domain
PF08028 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF03992 (9/9) Antibiotic biosynthesis monooxygenase
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF02779 (9/9) Transketolase, pyrimidine binding domain
PF01546 (9/9) Peptidase family M20/M25/M40
PF01370 (9/9) NAD dependent epimerase/dehydratase family
PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (9/9) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (9/9) Thioesterase domain
PF00698 (9/9) Acyl transferase domain
PF00696 (9/9) Amino acid kinase family
PF00668 (9/9) Condensation domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00456 (9/9) Transketolase, thiamine diphosphate binding domain
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF08240 (7/9) Alcohol dehydrogenase GroES-like domain
jaccard_groups_2753 62.20 +- 24.46 2 0 0 0 0.07 +- 0.07 2 9

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF13191 (1/2) AAA ATPase domain
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF02633 (1/2) Creatinine amidohydrolase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_2976 1003.03 +- 986.94 9 0 3 0 0.03 +- 0.08 9 14

TIGR00217 (9/9) 4-alpha-glucanotransferase
PF08323 (9/9) Starch synthase catalytic domain
PF08282 (9/9) haloacid dehalogenase-like hydrolase
PF07883 (9/9) Cupin domain
PF06182 (9/9) ABC-2 family transporter protein
PF04321 (9/9) RmlD substrate binding domain
PF02446 (9/9) 4-alpha-glucanotransferase
PF01761 (9/9) 3-dehydroquinate synthase
PF00483 (9/9) Nucleotidyl transferase
PF00480 (9/9) ROK family
PF00202 (9/9) Aminotransferase class-III
PF00005 (9/9) ABC transporter
PF13692 (7/9) Glycosyl transferases group 1
PF00294 (5/9) pfkB family carbohydrate kinase
jaccard_groups_5408 86.78 +- 64.99 2 0 1 0 0.14 +- 0.28 2 9

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00083 (2/2) Sugar (and other) transporter
PF13458 (1/2) Periplasmic binding protein
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF04672 (1/2) S-adenosyl methyltransferase
PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_710 166.75 +- 193.30 21 0 5 0 0.15 +- 0.21 21 4

PF00528 (21/21) Binding-protein-dependent transport system inner membrane component
PF00128 (21/21) Alpha amylase, catalytic domain
PF11941 (16/21) Domain of unknown function (DUF3459)
PF01547 (16/21) Bacterial extracellular solute-binding protein
jaccard_groups_2978 116.33 +- 15.55 9 0 0 0 0.08 +- 0.19 9 13

PF14117 (9/9) Domain of unknown function (DUF4287)
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF06197 (9/9) Protein of unknown function (DUF998)
PF02771 (9/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF01979 (9/9) Amidohydrolase family
PF01575 (9/9) MaoC like domain
PF00501 (9/9) AMP-binding enzyme
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (9/9) Aminotransferase class I and II
PF00132 (9/9) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_480 18.78 +- 2.76 3 0 2 0 0.18 +- 0.19 3 5

TIGR00738 (3/3) Rrf2 family protein
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02082 (3/3) Transcriptional regulator
PF05532 (2/3) CsbD-like
PF01979 (2/3) Amidohydrolase family
jaccard_groups_482 49.00 +- 0.14 2 0 0 0 0.14 +- 0.32 2 6

PF17964 (2/2) Bacterial Ig domain
PF13462 (2/2) Thioredoxin
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02600 (2/2) Disulfide bond formation protein DsbB
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
jaccard_groups_486 140.57 +- 81.81 12 0 0 0 0.02 +- 0.02 12 1

PF01833 (12/12) IPT/TIG domain
jaccard_groups_5979 296.14 +- 38.14 2 0 0 0 0.01 +- 0.01 2 7

TIGR01426 (2/2) glycosyltransferase, MGT family
PF14765 (2/2) Polyketide synthase dehydratase
PF13489 (2/2) Methyltransferase domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12697 (1/2) Alpha/beta hydrolase family
PF12146 (1/2) Serine aminopeptidase, S33
jaccard_groups_489 41.08 +- 70.21 97 0 11 0 0.17 +- 0.12 97 3

PF00111 (96/97) 2Fe-2S iron-sulfur cluster binding domain
PF00355 (95/97) Rieske [2Fe-2S] domain
PF00175 (93/97) Oxidoreductase NAD-binding domain
jaccard_groups_5974 449.42 +- 324.58 2 0 0 0 0.03 +- 0.09 2 10

PF13545 (2/2) Crp-like helix-turn-helix domain
PF13191 (2/2) AAA ATPase domain
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03176 (2/2) MMPL family
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00899 (2/2) ThiF family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_5973 35.57 +- 19.46 2 0 0 0 0.18 +- 0.21 2 8

PF13649 (2/2) Methyltransferase domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF12840 (1/2) Helix-turn-helix domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF00384 (1/2) Molybdopterin oxidoreductase
jaccard_groups_2577 258.23 +- 98.52 12 0 0 0 0.03 +- 0.03 12 15

PF17754 (12/12) MftR C-terminal domain
PF14525 (12/12) AraC-binding-like domain
PF12833 (12/12) Helix-turn-helix domain
PF08240 (12/12) Alcohol dehydrogenase GroES-like domain
PF04444 (12/12) Catechol dioxygenase N terminus
PF02776 (12/12) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (12/12) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (12/12) FAD binding domain
PF01425 (12/12) Amidase
PF01047 (12/12) MarR family
PF00775 (12/12) Dioxygenase
PF00465 (12/12) Iron-containing alcohol dehydrogenase
PF00205 (12/12) Thiamine pyrophosphate enzyme, central domain
PF00107 (12/12) Zinc-binding dehydrogenase
PF00106 (12/12) short chain dehydrogenase
jaccard_groups_3880 618.82 +- 525.18 2 0 2 0 0.06 +- 0.20 2 21

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01553 (2/2) Acyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00975 (2/2) Thioesterase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01575 (1/2) MaoC like domain
jaccard_groups_2573 262.58 +- 109.46 7 0 0 0 0.01 +- 0.01 7 6

PF17137 (7/7) Domain of unknown function (DUF5110)
PF16990 (7/7) Carbohydrate binding module (family 35)
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF03595 (7/7) Voltage-dependent anion channel
PF02852 (7/7) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01055 (7/7) Glycosyl hydrolases family 31
jaccard_groups_5991 140.32 +- 82.54 2 0 0 0 0.07 +- 0.19 2 12

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06684 (2/2) Amino acid synthesis
PF01361 (2/2) Tautomerase enzyme
PF00668 (2/2) Condensation domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_5999 69.17 +- 4.84 2 0 0 0 0.08 +- 0.13 2 13

TIGR03221 (2/2) muconolactone delta-isomerase
TIGR02438 (2/2) catechol 1,2-dioxygenase
PF13378 (2/2) Enolase C-terminal domain-like
PF04444 (2/2) Catechol dioxygenase N terminus
PF03466 (2/2) LysR substrate binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02426 (2/2) Muconolactone delta-isomerase
PF00775 (2/2) Dioxygenase
PF00561 (2/2) alpha/beta hydrolase fold
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF08386 (1/2) TAP-like protein
PF01609 (1/2) Transposase DDE domain
PF01144 (1/2) Coenzyme A transferase
jaccard_groups_3883 456.80 +- 178.91 5 0 5 0 0.02 +- 0.01 5 7

PF13394 (5/5) 4Fe-4S single cluster domain
PF01977 (5/5) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (5/5) 6-pyruvoyl tetrahydropterin synthase
PF01227 (5/5) GTP cyclohydrolase I
PF00478 (5/5) IMP dehydrogenase / GMP reductase domain
PF00293 (5/5) NUDIX domain
PF00156 (5/5) Phosphoribosyl transferase domain
jaccard_groups_5572 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
jaccard_groups_795 346.12 +- 80.03 7 0 1 0 0.02 +- 0.01 7 5

TIGR00574 (7/7) DNA ligase I, ATP-dependent (dnl1)
PF04679 (7/7) ATP dependent DNA ligase C terminal region
PF01068 (7/7) ATP dependent DNA ligase domain
PF04675 (5/7) DNA ligase N terminus
PF00067 (4/7) Cytochrome P450
jaccard_groups_5571 496.76 +- 283.24 2 0 2 0 0.02 +- 0.01 2 15

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
jaccard_groups_791 407.63 +- 442.09 8 0 0 0 0.04 +- 0.05 8 6

TIGR03168 (8/8) hexose kinase, 1-phosphofructokinase family
PF01116 (8/8) Fructose-bisphosphate aldolase class-II
PF00294 (8/8) pfkB family carbohydrate kinase
TIGR00167 (7/8) ketose-bisphosphate aldolase
PF00480 (6/8) ROK family
PF00528 (5/8) Binding-protein-dependent transport system inner membrane component
jaccard_groups_792 44.43 +- 64.11 5 0 1 0 0.19 +- 0.33 5 2

TIGR00753 (5/5) undecaprenyl-diphosphatase UppP
PF02673 (5/5) Bacitracin resistance protein BacA
jaccard_groups_5575 23.27 +- 0.64 2 0 0 0 0.09 +- 0.11 2 7

PF18029 (2/2) Glyoxalase-like domain
PF13518 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF13683 (1/2) Integrase core domain
PF13023 (1/2) HD domain
jaccard_groups_798 56.06 +- 44.55 3 0 1 0 0.13 +- 0.19 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF16859 (2/3) Tetracyclin repressor-like, C-terminal domain
jaccard_groups_2402 33.37 +- 5.15 2 0 0 0 0.15 +- 0.18 2 13

PF16262 (2/2) Domain of unknown function (DUF4916)
PF04909 (2/2) Amidohydrolase
PF04672 (2/2) S-adenosyl methyltransferase
PF00120 (2/2) Glutamine synthetase, catalytic domain
TIGR01179 (1/2) UDP-glucose 4-epimerase GalE
PF16952 (1/2) Glutamine synthetase N-terminal domain
PF13185 (1/2) GAF domain
PF11338 (1/2) Protein of unknown function (DUF3140)
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05231 (1/2) MASE1
PF03988 (1/2) Repeat of Unknown Function (DUF347)
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00210 (1/2) Ferritin-like domain
jaccard_groups_5358 272.17 +- 18.67 2 0 0 0 0.05 +- 0.07 2 9

PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02633 (2/2) Creatinine amidohydrolase
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF04149 (1/2) Domain of unknown function (DUF397)
jaccard_groups_3923 411.78 +- 134.34 5 0 3 0 0.02 +- 0.03 5 14

TIGR03619 (5/5) probable F420-dependent oxidoreductase, Rv2161c family
PF07977 (5/5) FabA-like domain
PF03061 (5/5) Thioesterase superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00296 (5/5) Luciferase-like monooxygenase
PF00202 (5/5) Aminotransferase class-III
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
PF14864 (4/5) Alkyl sulfatase C-terminal
PF13847 (4/5) Methyltransferase domain
PF14863 (3/5) Alkyl sulfatase dimerisation
PF09076 (3/5) Beta/Gamma crystallin
PF00753 (3/5) Metallo-beta-lactamase superfamily
jaccard_groups_5194 64.93 +- 18.52 3 0 3 0 0.14 +- 0.32 3 17

PF08326 (3/3) Acetyl-CoA carboxylase, central region
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF01039 (3/3) Carboxyl transferase domain
PF00891 (3/3) O-methyltransferase domain
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
TIGR00612 (2/3) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
TIGR00216 (2/3) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
PF11468 (2/3) Aromatic prenyltransferase Orf2
PF07690 (2/3) Major Facilitator Superfamily
PF04551 (2/3) GcpE protein
PF02401 (2/3) LytB protein
PF01255 (2/3) Putative undecaprenyl diphosphate synthase
PF00501 (2/3) AMP-binding enzyme
PF00348 (2/3) Polyprenyl synthetase
PF00293 (2/3) NUDIX domain
jaccard_groups_334 70.31 +- 42.42 58 0 1 0 0.19 +- 0.24 58 9

PF00296 (58/58) Luciferase-like monooxygenase
PF13454 (55/58) FAD-NAD(P)-binding
TIGR03860 (51/58) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07920 (51/58) Protein of unknown function (DUF1684)
PF02983 (51/58) Alpha-lytic protease prodomain
PF00089 (50/58) Trypsin
TIGR01726 (33/58) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (32/58) Binding-protein-dependent transport system inner membrane component
PF00005 (32/58) ABC transporter
jaccard_groups_5756 585.00 +- 195.00 2 0 0 2 0.01 +- 0.01 2 7

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
jaccard_groups_866 35.30 +- 14.07 6 0 0 0 0.07 +- 0.08 6 3

PF09586 (6/6) Bacterial membrane protein YfhO
PF04138 (6/6) GtrA-like protein
PF00535 (6/6) Glycosyl transferase family 2
jaccard_groups_867 29.46 +- 2.79 2 0 0 0 0.12 +- 0.21 2 4

PF01590 (2/2) GAF domain
PF04294 (1/2) VanW like protein
PF02954 (1/2) Bacterial regulatory protein, Fis family
PF02585 (1/2) GlcNAc-PI de-N-acetylase
jaccard_groups_864 1611.61 +- 1734.45 92 0 18 0 0.02 +- 0.07 92 9

PF17914 (91/92) HopA1 effector protein family
PF02441 (89/92) Flavoprotein
PF00675 (83/92) Insulinase (Peptidase family M16)
PF00005 (81/92) ABC transporter
PF05193 (79/92) Peptidase M16 inactive domain
PF00296 (74/92) Luciferase-like monooxygenase
PF01636 (54/92) Phosphotransferase enzyme family
PF00664 (54/92) ABC transporter transmembrane region
PF13649 (47/92) Methyltransferase domain
jaccard_groups_1274 239.35 +- 316.71 34 0 34 1 0.12 +- 0.25 34 15

PF02771 (34/34) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (34/34) Acyl-CoA dehydrogenase, middle domain
PF02737 (34/34) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (34/34) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (34/34) Phosphopantetheine attachment site
PF00441 (34/34) Acyl-CoA dehydrogenase, C-terminal domain
PF02801 (31/34) Beta-ketoacyl synthase, C-terminal domain
PF00109 (31/34) Beta-ketoacyl synthase, N-terminal domain
TIGR01686 (30/34) FkbH domain
PF13193 (28/34) AMP-binding enzyme C-terminal domain
PF00501 (28/34) AMP-binding enzyme
TIGR01733 (27/34) amino acid adenylation domain
PF16197 (27/34) Ketoacyl-synthetase C-terminal extension
PF00975 (25/34) Thioesterase domain
PF00668 (25/34) Condensation domain
jaccard_groups_1276 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
jaccard_groups_1270 348.73 +- 278.36 4 0 4 0 0.09 +- 0.21 4 14

PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (2/4) 4Fe-4S single cluster domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF02195 (2/4) ParB-like nuclease domain
PF01266 (2/4) FAD dependent oxidoreductase
PF00975 (2/4) Thioesterase domain
PF00067 (2/4) Cytochrome P450
PF00005 (2/4) ABC transporter
jaccard_groups_1182 60.82 +- 31.11 5 0 0 0 0.16 +- 0.27 5 16

TIGR02378 (5/5) nitrite reductase [NAD(P)H], small subunit
TIGR02374 (5/5) nitrite reductase [NAD(P)H], large subunit
PF18267 (5/5) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (5/5) Rieske-like [2Fe-2S] domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (5/5) BFD-like [2Fe-2S] binding domain
PF03460 (5/5) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (5/5) Nitrite and sulphite reductase 4Fe-4S domain
PF11308 (4/5) Glycosyl hydrolases related to GH101 family, GH129
PF00106 (4/5) short chain dehydrogenase
TIGR03083 (3/5) uncharacterized Actinobacterial protein TIGR03083
PF13520 (3/5) Amino acid permease
PF12840 (3/5) Helix-turn-helix domain
PF11716 (3/5) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08327 (3/5) Activator of Hsp90 ATPase homolog 1-like protein
PF07398 (3/5) MDMPI C-terminal domain
jaccard_groups_1181 16.95 +- 7.53 3 0 0 0 0.19 +- 0.34 3 5

TIGR03592 (3/3) membrane protein insertase, YidC/Oxa1 family
PF02096 (3/3) 60Kd inner membrane protein
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF11755 (2/3) Protein of unknown function (DUF3311)
PF00474 (2/3) Sodium:solute symporter family
jaccard_groups_1180 71.16 +- 39.02 17 0 0 0 0.20 +- 0.22 17 15

PF01547 (16/17) Bacterial extracellular solute-binding protein
PF00544 (16/17) Pectate lyase
PF14100 (15/17) Methane oxygenase PmoA
PF04616 (15/17) Glycosyl hydrolases family 43
PF01408 (15/17) Oxidoreductase family, NAD-binding Rossmann fold
PF17851 (14/17) Beta xylosidase C-terminal Concanavalin A-like domain
PF13472 (14/17) GDSL-like Lipase/Acylhydrolase family
PF01095 (14/17) Pectinesterase
PF00528 (13/17) Binding-protein-dependent transport system inner membrane component
PF07729 (12/17) FCD domain
PF00701 (12/17) Dihydrodipicolinate synthetase family
PF00392 (12/17) Bacterial regulatory proteins, gntR family
PF00920 (11/17) Dehydratase family
TIGR03086 (10/17) TIGR03086 family protein
PF11716 (10/17) Mycothiol maleylpyruvate isomerase N-terminal domain
jaccard_groups_138 88.84 +- 48.74 4 0 0 0 0.06 +- 0.07 4 4

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF02638 (2/4) Glycosyl hydrolase-like 10
PF01471 (2/4) Putative peptidoglycan binding domain
jaccard_groups_139 280.33 +- 199.07 6 0 4 0 0.05 +- 0.17 6 9

PF02780 (6/6) Transketolase, C-terminal domain
PF00676 (6/6) Dehydrogenase E1 component
PF00364 (6/6) Biotin-requiring enzyme
PF00198 (6/6) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF02779 (5/6) Transketolase, pyrimidine binding domain
PF08545 (3/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02817 (3/6) e3 binding domain
PF00550 (3/6) Phosphopantetheine attachment site
jaccard_groups_1879 680.98 +- 800.50 18 0 1 0 0.05 +- 0.07 18 13

PF14310 (18/18) Fibronectin type III-like domain
PF01915 (18/18) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (18/18) Glycosyl hydrolase family 3 N terminal domain
PF00528 (18/18) Binding-protein-dependent transport system inner membrane component
PF13416 (17/18) Bacterial extracellular solute-binding protein
PF13377 (17/18) Periplasmic binding protein-like domain
PF00356 (17/18) Bacterial regulatory proteins, lacI family
PF17189 (11/18) Glycosyl hydrolase family 30 beta sandwich domain
PF08244 (11/18) Glycosyl hydrolases family 32 C terminal
PF02055 (11/18) Glycosyl hydrolase family 30 TIM-barrel domain
PF01833 (11/18) IPT/TIG domain
PF00754 (11/18) F5/8 type C domain
PF00251 (11/18) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_130 173.75 +- 295.28 13 0 5 0 0.06 +- 0.08 13 1

PF00348 (13/13) Polyprenyl synthetase
jaccard_groups_131 224.27 +- 49.13 3 0 3 0 0.01 +- 0.00 3 4

TIGR01490 (3/3) HAD hydrolase, family IB
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF03756 (3/3) A-factor biosynthesis hotdog domain
jaccard_groups_1877 213.36 +- 149.11 8 0 8 1 0.04 +- 0.05 8 6

PF00975 (8/8) Thioesterase domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF01370 (6/8) NAD dependent epimerase/dehydratase family
PF07690 (4/8) Major Facilitator Superfamily
PF00155 (4/8) Aminotransferase class I and II
jaccard_groups_135 79.56 +- 68.28 10 0 0 0 0.10 +- 0.22 10 3

PF07992 (10/10) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (8/10) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF00903 (5/10) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1874 166.86 +- 93.14 2 0 1 0 0.02 +- 0.02 2 5

PF04138 (2/2) GtrA-like protein
PF00535 (2/2) Glycosyl transferase family 2
PF13632 (1/2) Glycosyl transferase family group 2
PF13437 (1/2) HlyD family secretion protein
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
jaccard_groups_1476 27.08 +- 12.12 19 0 0 0 0.15 +- 0.30 19 9

PF07714 (19/19) Protein tyrosine kinase
PF06723 (19/19) MreB/Mbl protein
PF03704 (19/19) Bacterial transcriptional activator domain
PF13185 (17/19) GAF domain
PF07730 (17/19) Histidine kinase
PF07728 (17/19) AAA domain (dynein-related subfamily)
PF03861 (15/19) ANTAR domain
PF13365 (14/19) Trypsin-like peptidase domain
PF13466 (11/19) STAS domain
jaccard_groups_1475 33.10 +- 24.39 6 0 0 0 0.13 +- 0.26 6 4

TIGR00008 (6/6) translation initiation factor IF-1
PF13673 (6/6) Acetyltransferase (GNAT) domain
PF01176 (6/6) Translation initiation factor 1A / IF-1
PF03992 (3/6) Antibiotic biosynthesis monooxygenase
jaccard_groups_1473 230.96 +- 229.71 40 0 9 0 0.06 +- 0.08 40 5

PF00528 (40/40) Binding-protein-dependent transport system inner membrane component
PF01547 (38/40) Bacterial extracellular solute-binding protein
PF13378 (31/40) Enolase C-terminal domain-like
PF02746 (31/40) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF05336 (20/40) L-rhamnose mutarotase
jaccard_groups_1471 221.60 +- 92.88 7 0 5 0 0.01 +- 0.02 7 3

PF13517 (7/7) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF06737 (7/7) Transglycosylase-like domain
PF08924 (4/7) Domain of unknown function (DUF1906)
jaccard_groups_4133 198.26 +- 30.71 4 0 0 0 0.02 +- 0.01 4 6

PF12740 (4/4) Chlorophyllase enzyme
PF08223 (4/4) PaaX-like protein C-terminal domain
PF07848 (4/4) PaaX-like protein
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF00069 (4/4) Protein kinase domain
PF17765 (2/4) MmyB-like transcription regulator ligand binding domain
jaccard_groups_1478 507.76 +- 624.60 40 2 38 40 0.07 +- 0.21 38 12

PF13471 (40/40) Transglutaminase-like superfamily
PF05402 (40/40) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (40/40) ABC-2 type transporter
PF00005 (40/40) ABC transporter
PF00733 (39/40) Asparagine synthase
PF13462 (35/40) Thioredoxin
PF12730 (34/40) ABC-2 family transporter protein
PF09587 (32/40) Bacterial capsule synthesis protein PGA_cap
PF07730 (29/40) Histidine kinase
PF07291 (29/40) Methylamine utilisation protein MauE
PF00196 (26/40) Bacterial regulatory proteins, luxR family
PF00072 (26/40) Response regulator receiver domain
jaccard_groups_3838 63.94 +- 30.61 2 0 1 0 0.05 +- 0.07 2 6

PF17829 (2/2) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (2/2) Glycosyl hydrolase family 115
PF13191 (2/2) AAA ATPase domain
PF00067 (2/2) Cytochrome P450
PF17996 (1/2) Carbohydrate esterase 2 N-terminal
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
jaccard_groups_1984 36.98 +- 6.02 2 0 0 0 0.07 +- 0.04 2 6

PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07730 (2/2) Histidine kinase
PF00890 (2/2) FAD binding domain
PF00083 (2/2) Sugar (and other) transporter
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_1981 392.90 +- 135.87 17 0 16 14 0.01 +- 0.01 17 5

PF13454 (17/17) FAD-NAD(P)-binding
PF13302 (17/17) Acetyltransferase (GNAT) domain
PF02801 (17/17) Beta-ketoacyl synthase, C-terminal domain
PF00109 (17/17) Beta-ketoacyl synthase, N-terminal domain
PF05147 (14/17) Lanthionine synthetase C-like protein
jaccard_groups_4481 47.35 +- 37.67 3 0 0 0 0.13 +- 0.23 3 15

TIGR00229 (3/3) PAS domain S-box protein
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13520 (3/3) Amino acid permease
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF06386 (3/3) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (3/3) Gas vesicle synthesis protein GvpO
PF05121 (3/3) Gas vesicle protein K
PF05120 (3/3) Gas vesicle protein G
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01590 (3/3) GAF domain
PF00989 (3/3) PAS fold
PF00741 (3/3) Gas vesicle protein
PF00083 (3/3) Sugar (and other) transporter
PF00005 (2/3) ABC transporter
jaccard_groups_4480 903.00 +- 0.00 4 0 4 0 0.01 +- 0.00 4 9

PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (4/4) Major Facilitator Superfamily
PF07366 (4/4) SnoaL-like polyketide cyclase
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00501 (4/4) AMP-binding enzyme
PF00171 (4/4) Aldehyde dehydrogenase family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12680 (3/4) SnoaL-like domain
jaccard_groups_4483 949.65 +- 536.31 4 0 4 0 0.02 +- 0.02 4 19

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF01619 (4/4) Proline dehydrogenase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00487 (4/4) Fatty acid desaturase
PF00326 (4/4) Prolyl oligopeptidase family
PF00266 (4/4) Aminotransferase class-V
PF00067 (4/4) Cytochrome P450
PF17874 (2/4) MalT-like TPR region
PF13649 (2/4) Methyltransferase domain
PF13560 (2/4) Helix-turn-helix domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF12697 (2/4) Alpha/beta hydrolase family
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02441 (2/4) Flavoprotein
PF00005 (2/4) ABC transporter
jaccard_groups_4482 2165.48 +- 590.36 4 0 4 0 0.03 +- 0.14 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (4/4) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF18563 (4/4) TubC N-terminal docking domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08659 (4/4) KR domain
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00005 (4/4) ABC transporter
TIGR01686 (3/4) FkbH domain
PF13602 (3/4) Zinc-binding dehydrogenase
PF08240 (3/4) Alcohol dehydrogenase GroES-like domain
PF02737 (3/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/4) ParB-like nuclease domain
PF01266 (3/4) FAD dependent oxidoreductase
PF00725 (3/4) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_5509 218.73 +- 58.90 2 0 0 0 0.06 +- 0.12 2 14

PF09084 (2/2) NMT1/THI5 like
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
TIGR03567 (1/2) FMN reductase
TIGR01766 (1/2) transposase, IS605 OrfB family
PF12323 (1/2) Helix-turn-helix domain
PF08386 (1/2) TAP-like protein
PF07282 (1/2) Putative transposase DNA-binding domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF01385 (1/2) Probable transposase
jaccard_groups_5508 127.39 +- 21.46 2 0 0 0 0.12 +- 0.18 2 15

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13407 (2/2) Periplasmic binding protein domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04199 (2/2) Putative cyclase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF00575 (1/2) S1 RNA binding domain
jaccard_groups_1054 180.81 +- 125.53 8 0 0 0 0.02 +- 0.02 8 3

PF07582 (8/8) AP endonuclease family 2 C terminus
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (8/8) Xylose isomerase-like TIM barrel
jaccard_groups_1509 465.38 +- 414.96 36 0 5 0 0.05 +- 0.06 36 5

PF05426 (36/36) Alginate lyase
PF00295 (33/36) Glycosyl hydrolases family 28
PF00528 (32/36) Binding-protein-dependent transport system inner membrane component
PF01547 (23/36) Bacterial extracellular solute-binding protein
PF00135 (18/36) Carboxylesterase family
jaccard_groups_1052 90.83 +- 82.13 12 0 7 0 0.08 +- 0.09 12 2

PF11575 (12/12) FhuF 2Fe-2S C-terminal domain
PF04616 (8/12) Glycosyl hydrolases family 43
jaccard_groups_1503 580.50 +- 193.50 2 0 0 2 0.01 +- 0.00 2 5

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF00881 (2/2) Nitroreductase family
PF08007 (1/2) Cupin superfamily protein
PF07690 (1/2) Major Facilitator Superfamily
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_1501 94.48 +- 21.19 37 0 0 0 0.14 +- 0.25 37 11

PF08795 (37/37) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (37/37) Animal haem peroxidase
PF02585 (37/37) GlcNAc-PI de-N-acetylase
PF01061 (37/37) ABC-2 type transporter
PF00933 (37/37) Glycosyl hydrolase family 3 N terminal domain
PF00582 (37/37) Universal stress protein family
PF00199 (37/37) Catalase
PF00005 (37/37) ABC transporter
TIGR00229 (34/37) PAS domain S-box protein
PF00196 (34/37) Bacterial regulatory proteins, luxR family
PF00989 (31/37) PAS fold
jaccard_groups_4006 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1059 56.84 +- 25.17 20 0 0 0 0.14 +- 0.06 20 10

PF13370 (20/20) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (20/20) Pyridine nucleotide-disulphide oxidoreductase
PF06314 (20/20) Acetoacetate decarboxylase (ADC)
PF02900 (20/20) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01557 (20/20) Fumarylacetoacetate (FAA) hydrolase family
PF00171 (20/20) Aldehyde dehydrogenase family
PF14759 (19/20) Reductase C-terminal
PF17940 (15/20) Tetracyclin repressor-like, C-terminal domain
PF00440 (15/20) Bacterial regulatory proteins, tetR family
PF07722 (12/20) Peptidase C26
jaccard_groups_4003 306.48 +- 53.04 3 0 0 0 0.04 +- 0.05 3 11

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13229 (3/3) Right handed beta helix region
PF07745 (3/3) Glycosyl hydrolase family 53
PF07532 (3/3) Bacterial Ig-like domain (group 4)
PF04616 (3/3) Glycosyl hydrolases family 43
PF03422 (3/3) Carbohydrate binding module (family 6)
PF00754 (3/3) F5/8 type C domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF03583 (2/3) Secretory lipase
PF01522 (2/3) Polysaccharide deacetylase
jaccard_groups_1504 56.12 +- 11.39 4 0 0 0 0.04 +- 0.02 4 2

PF11706 (4/4) CGNR zinc finger
PF08962 (4/4) Domain of unknown function (DUF1876)
jaccard_groups_1698 63.06 +- 54.78 10 0 0 0 0.05 +- 0.04 10 2

PF02734 (10/10) DAK2 domain
PF02733 (10/10) Dak1 domain
jaccard_groups_1691 299.67 +- 331.64 15 0 0 0 0.08 +- 0.14 15 8

PF13378 (15/15) Enolase C-terminal domain-like
PF07729 (15/15) FCD domain
PF02746 (15/15) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (15/15) Bacterial extracellular solute-binding protein
PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF00392 (15/15) Bacterial regulatory proteins, gntR family
PF00754 (11/15) F5/8 type C domain
PF00480 (9/15) ROK family
jaccard_groups_310 213.16 +- 153.38 14 0 1 0 0.05 +- 0.12 14 3

PF02779 (14/14) Transketolase, pyrimidine binding domain
PF00456 (12/14) Transketolase, thiamine diphosphate binding domain
PF02780 (10/14) Transketolase, C-terminal domain
jaccard_groups_312 33.78 +- 40.46 7 0 1 0 0.16 +- 0.17 7 3

PF07728 (7/7) AAA domain (dynein-related subfamily)
PF13569 (4/7) Domain of unknown function (DUF4132)
PF05762 (4/7) VWA domain containing CoxE-like protein
jaccard_groups_313 129.91 +- 77.47 6 0 0 0 0.05 +- 0.15 6 3

PF00581 (6/6) Rhodanese-like domain
PF05995 (4/6) Cysteine dioxygenase type I
PF06094 (3/6) Gamma-glutamyl cyclotransferase, AIG2-like
jaccard_groups_315 126.84 +- 86.24 5 0 1 0 0.04 +- 0.07 5 1

PF01569 (5/5) PAP2 superfamily
jaccard_groups_316 49.38 +- 29.98 10 0 0 0 0.06 +- 0.04 10 2

PF00724 (10/10) NADH:flavin oxidoreductase / NADH oxidase family
PF00171 (7/10) Aldehyde dehydrogenase family
jaccard_groups_4798 145.32 +- 89.23 2 0 1 0 0.06 +- 0.14 2 13

TIGR01205 (2/2) D-alanine--D-alanine ligase
TIGR00492 (2/2) alanine racemase
PF07730 (2/2) Histidine kinase
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00842 (2/2) Alanine racemase, C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF12840 (1/2) Helix-turn-helix domain
PF05977 (1/2) Transmembrane secretion effector
PF01427 (1/2) D-ala-D-ala dipeptidase
PF00005 (1/2) ABC transporter
jaccard_groups_4265 917.74 +- 551.90 4 0 0 0 0.01 +- 0.01 4 10

TIGR04377 (4/4) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
PF03328 (4/4) HpcH/HpaI aldolase/citrate lyase family
PF02894 (4/4) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_4266 148.59 +- 34.70 4 0 4 0 0.09 +- 0.18 4 12

PF13641 (4/4) Glycosyltransferase like family 2
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00925 (4/4) GTP cyclohydrolase II
PF00400 (4/4) WD domain, G-beta repeat
PF10823 (3/4) Protein of unknown function (DUF2568)
PF09335 (3/4) SNARE associated Golgi protein
PF01810 (3/4) LysE type translocator
PF00583 (3/4) Acetyltransferase (GNAT) family
PF00067 (3/4) Cytochrome P450
jaccard_groups_4260 256.45 +- 192.53 4 0 0 0 0.08 +- 0.23 4 12

PF16864 (4/4) Dimerisation domain
PF08962 (4/4) Domain of unknown function (DUF1876)
PF03704 (4/4) Bacterial transcriptional activator domain
PF01323 (4/4) DSBA-like thioredoxin domain
PF00931 (4/4) NB-ARC domain
PF00891 (4/4) O-methyltransferase domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
TIGR00710 (2/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (2/4) Major Facilitator Superfamily
PF05423 (2/4) Mycobacterium membrane protein
PF00724 (2/4) NADH:flavin oxidoreductase / NADH oxidase family
PF00440 (2/4) Bacterial regulatory proteins, tetR family
jaccard_groups_18 26.80 +- 21.00 5 0 2 0 0.13 +- 0.25 5 2

PF00271 (5/5) Helicase conserved C-terminal domain
PF00270 (5/5) DEAD/DEAH box helicase
jaccard_groups_19 135.77 +- 158.56 92 1 18 2 0.08 +- 0.19 91 3

PF07228 (91/92) Stage II sporulation protein E (SpoIIE)
PF08448 (67/92) PAS fold
TIGR00229 (59/92) PAS domain S-box protein
jaccard_groups_4317 673.65 +- 236.08 4 0 0 0 0.02 +- 0.05 4 16

PF18448 (4/4) Carbohydrate binding domain
PF17851 (4/4) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (4/4) Domain of unknown function(DUF4981)
PF14310 (4/4) Fibronectin type III-like domain
PF04616 (4/4) Glycosyl hydrolases family 43
PF03442 (4/4) Carbohydrate binding domain X2
PF03422 (4/4) Carbohydrate binding module (family 6)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (4/4) Alpha-L-fucosidase
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF15902 (3/4) Sortilin, neurotensin receptor 3,
PF14200 (3/4) Ricin-type beta-trefoil lectin domain-like
jaccard_groups_14 267.59 +- 405.96 99 0 18 2 0.09 +- 0.13 99 3

PF13377 (99/99) Periplasmic binding protein-like domain
PF00356 (98/99) Bacterial regulatory proteins, lacI family
PF00528 (51/99) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4318 18.64 +- 4.46 2 0 0 0 0.17 +- 0.12 2 8

PF09339 (2/2) IclR helix-turn-helix domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01614 (2/2) Bacterial transcriptional regulator
PF00942 (2/2) Cellulose binding domain
PF00722 (2/2) Glycosyl hydrolases family 16
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (1/2) Glycosyl hydrolase family 92
jaccard_groups_16 97.51 +- 116.84 16 0 1 0 0.09 +- 0.15 16 2

PF03466 (16/16) LysR substrate binding domain
PF00126 (16/16) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_17 114.76 +- 122.35 75 0 4 1 0.06 +- 0.10 75 2

PF07702 (75/75) UTRA domain
PF00392 (75/75) Bacterial regulatory proteins, gntR family
jaccard_groups_10 206.23 +- 208.50 19 0 7 1 0.05 +- 0.10 19 2

PF03704 (17/19) Bacterial transcriptional activator domain
PF00486 (17/19) Transcriptional regulatory protein, C terminal
jaccard_groups_11 101.61 +- 141.47 117 0 13 5 0.12 +- 0.21 117 5

PF02518 (117/117) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (116/117) His Kinase A (phospho-acceptor) domain
PF00072 (113/117) Response regulator receiver domain
PF00486 (110/117) Transcriptional regulatory protein, C terminal
PF00672 (101/117) HAMP domain
jaccard_groups_12 25.83 +- 3.06 2 0 0 0 0.08 +- 0.07 2 4

PF13581 (2/2) Histidine kinase-like ATPase domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF07045 (1/2) Domain of unknown function (DUF1330)
PF00027 (1/2) Cyclic nucleotide-binding domain
jaccard_groups_13 129.74 +- 93.25 4 0 0 0 0.09 +- 0.18 4 4

PF04149 (4/4) Domain of unknown function (DUF397)
PF03752 (2/4) Short repeats of unknown function
PF01381 (2/4) Helix-turn-helix
PF00857 (2/4) Isochorismatase family
jaccard_groups_3908 1645.66 +- 1357.34 2 0 2 1 0.05 +- 0.19 2 38

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
TIGR00761 (2/2) acetylglutamate kinase
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF05977 (2/2) Transmembrane secretion effector
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02039 (1/2) sulfate adenylyltransferase, small subunit
TIGR02034 (1/2) sulfate adenylyltransferase, large subunit
TIGR00455 (1/2) adenylyl-sulfate kinase
PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01583 (1/2) Adenylylsulphate kinase
PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00009 (1/2) Elongation factor Tu GTP binding domain
jaccard_groups_3906 214.25 +- 177.11 4 0 0 0 0.02 +- 0.01 4 4

PF07690 (4/4) Major Facilitator Superfamily
PF00171 (4/4) Aldehyde dehydrogenase family
PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA)
PF03055 (2/4) Retinal pigment epithelial membrane protein
jaccard_groups_3900 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily
jaccard_groups_3903 161.65 +- 77.68 5 0 0 0 0.13 +- 0.22 5 17

PF13796 (5/5) Putative sensor
PF07730 (5/5) Histidine kinase
PF07729 (5/5) FCD domain
PF04303 (5/5) PrpF protein
PF03737 (5/5) Aldolase/RraA
PF02585 (5/5) GlcNAc-PI de-N-acetylase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
PF00005 (5/5) ABC transporter
PF07690 (4/5) Major Facilitator Superfamily
PF04444 (4/5) Catechol dioxygenase N terminus
PF00775 (4/5) Dioxygenase
PF00465 (4/5) Iron-containing alcohol dehydrogenase
TIGR03211 (3/5) catechol 2,3 dioxygenase
PF12730 (3/5) ABC-2 family transporter protein
jaccard_groups_4869 1871.73 +- 868.78 3 0 0 2 0.01 +- 0.02 3 10

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF05448 (3/3) Acetyl xylan esterase (AXE1)
PF04324 (3/3) BFD-like [2Fe-2S] binding domain
PF03473 (3/3) MOSC domain
PF01523 (3/3) Putative modulator of DNA gyrase
PF01061 (3/3) ABC-2 type transporter
PF00334 (3/3) Nucleoside diphosphate kinase
PF00005 (3/3) ABC transporter
PF05402 (2/3) Coenzyme PQQ synthesis protein D (PqqD)
jaccard_groups_2984 263.15 +- 115.48 7 0 6 0 0.04 +- 0.03 7 12

TIGR01356 (7/7) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (7/7) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF01676 (7/7) Metalloenzyme superfamily
PF00275 (7/7) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (7/7) Glutamine amidotransferase class-I
PF04879 (6/7) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (6/7) Molydopterin dinucleotide binding domain
PF00384 (6/7) Molybdopterin oxidoreductase
TIGR02138 (4/7) phosphate ABC transporter, permease protein PstC
PF12849 (4/7) PBP superfamily domain
PF00528 (4/7) Binding-protein-dependent transport system inner membrane component
PF00005 (4/7) ABC transporter
jaccard_groups_4863 113.24 +- 45.10 3 0 0 0 0.03 +- 0.03 3 3

PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF00106 (3/3) short chain dehydrogenase
PF00067 (3/3) Cytochrome P450
jaccard_groups_2981 125.65 +- 72.69 3 0 0 0 0.06 +- 0.16 3 13

TIGR00034 (3/3) 3-deoxy-7-phosphoheptulonate synthase
PF13458 (3/3) Periplasmic binding protein
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF07732 (3/3) Multicopper oxidase
PF07731 (3/3) Multicopper oxidase
PF01494 (3/3) FAD binding domain
PF01474 (3/3) Class-II DAHP synthetase family
PF00793 (3/3) DAHP synthetase I family
PF00501 (3/3) AMP-binding enzyme
PF13191 (2/3) AAA ATPase domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_3340 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
jaccard_groups_3347 70.37 +- 15.63 2 0 1 0 0.03 +- 0.02 2 5

PF08241 (2/2) Methyltransferase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF01757 (1/2) Acyltransferase family
PF01610 (1/2) Transposase
PF00248 (1/2) Aldo/keto reductase family
jaccard_groups_3345 488.91 +- 562.03 4 0 1 0 0.03 +- 0.02 4 11

PF11723 (4/4) Homotrimeric ring hydroxylase
PF09339 (4/4) IclR helix-turn-helix domain
PF07687 (4/4) Peptidase dimerisation domain
PF02900 (4/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01614 (4/4) Bacterial transcriptional regulator
PF00355 (4/4) Rieske [2Fe-2S] domain
PF13452 (3/4) N-terminal half of MaoC dehydratase
PF12697 (3/4) Alpha/beta hydrolase family
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF01575 (2/4) MaoC like domain
PF00037 (2/4) 4Fe-4S binding domain
jaccard_groups_3236 65.22 +- 2.46 2 0 0 0 0.12 +- 0.29 2 9

PF07730 (2/2) Histidine kinase
PF02767 (2/2) DNA polymerase III beta subunit, central domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00266 (2/2) Aminotransferase class-V
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
PF00072 (2/2) Response regulator receiver domain
PF13411 (1/2) MerR HTH family regulatory protein
PF00376 (1/2) MerR family regulatory protein
jaccard_groups_3235 249.37 +- 151.03 2 0 2 0 0.07 +- 0.07 2 7

PF09084 (2/2) NMT1/THI5 like
PF01937 (2/2) Protein of unknown function DUF89
PF01483 (2/2) Proprotein convertase P-domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
jaccard_groups_3238 46.55 +- 33.28 3 0 0 2 0.13 +- 0.20 3 8

PF13560 (3/3) Helix-turn-helix domain
PF12900 (3/3) Pyridoxamine 5'-phosphate oxidase
PF08962 (3/3) Domain of unknown function (DUF1876)
PF08940 (3/3) Domain of unknown function (DUF1918)
PF03633 (3/3) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (3/3) Glycosyl hydrolase family 65 central catalytic domain
PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF00881 (2/3) Nitroreductase family
jaccard_groups_264 102.10 +- 121.87 44 0 28 0 0.10 +- 0.19 44 4

PF00484 (44/44) Carbonic anhydrase
PF00916 (41/44) Sulfate permease family
PF07690 (28/44) Major Facilitator Superfamily
PF03756 (25/44) A-factor biosynthesis hotdog domain
jaccard_groups_265 87.53 +- 70.42 10 0 2 0 0.08 +- 0.20 10 6

PF17657 (10/10) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (10/10) Helix-hairpin-helix motif
PF07733 (10/10) Bacterial DNA polymerase III alpha NTPase domain
TIGR00594 (9/10) DNA polymerase III, alpha subunit
PF02811 (9/10) PHP domain
PF11799 (7/10) impB/mucB/samB family C-terminal domain
jaccard_groups_266 36.23 +- 11.47 4 0 0 0 0.19 +- 0.15 4 6

PF06628 (4/4) Catalase-related immune-responsive
PF00199 (4/4) Catalase
PF18011 (3/4) C-terminal domain found in long catalases
PF10022 (2/4) Uncharacterized protein conserved in bacteria (DUF2264)
PF02826 (2/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
jaccard_groups_267 146.36 +- 157.19 3 0 0 0 0.04 +- 0.05 3 4

PF07510 (3/3) Protein of unknown function (DUF1524)
PF03235 (3/3) Protein of unknown function DUF262
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00067 (2/3) Cytochrome P450
jaccard_groups_260 209.64 +- 69.74 4 0 0 0 0.01 +- 0.02 4 2

PF10935 (4/4) Protein of unknown function (DUF2637)
PF00239 (3/4) Resolvase, N terminal domain
jaccard_groups_261 126.32 +- 121.34 8 0 0 0 0.07 +- 0.11 8 2

PF03358 (8/8) NADPH-dependent FMN reductase
TIGR01755 (4/8) NAD(P)H:quinone oxidoreductase, type IV
jaccard_groups_269 177.38 +- 236.21 26 0 2 1 0.10 +- 0.17 26 3

PF02129 (26/26) X-Pro dipeptidyl-peptidase (S15 family)
PF08530 (23/26) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
TIGR00976 (21/26) hydrolase CocE/NonD family protein
jaccard_groups_2185 30.36 +- 4.04 2 0 1 2 0.07 +- 0.08 2 4

PF12833 (2/2) Helix-turn-helix domain
PF08922 (2/2) Domain of unknown function (DUF1905)
PF06445 (2/2) GyrI-like small molecule binding domain
PF05147 (2/2) Lanthionine synthetase C-like protein
jaccard_groups_3697 285.38 +- 234.62 2 0 0 0 0.04 +- 0.11 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
jaccard_groups_3164 359.10 +- 168.18 8 0 8 0 0.03 +- 0.03 8 10

PF13450 (8/8) NAD(P)-binding Rossmann-like domain
PF07690 (8/8) Major Facilitator Superfamily
PF05721 (8/8) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (8/8) Taurine catabolism dioxygenase TauD, TfdA family
PF00348 (8/8) Polyprenyl synthetase
PF00106 (8/8) short chain dehydrogenase
PF00743 (5/8) Flavin-binding monooxygenase-like
TIGR01534 (4/8) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (4/8) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (4/8) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
jaccard_groups_3162 1159.42 +- 342.97 8 0 0 0 0.04 +- 0.12 8 16

PF18565 (8/8) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (8/8) Domain of unknown function (DUF4982)
PF07859 (8/8) alpha/beta hydrolase fold
PF03737 (8/8) Aldolase/RraA
PF02837 (8/8) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (8/8) Glycosyl hydrolases family 2, TIM barrel domain
PF02775 (8/8) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01558 (8/8) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (8/8) Xylose isomerase-like TIM barrel
PF00703 (8/8) Glycosyl hydrolases family 2
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00440 (8/8) Bacterial regulatory proteins, tetR family
PF00155 (8/8) Aminotransferase class I and II
PF00756 (4/8) Putative esterase
jaccard_groups_4144 661.08 +- 241.91 4 0 0 0 0.03 +- 0.02 4 12

PF17390 (4/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (4/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (4/4) Alpha-L-rhamnosidase N-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05592 (4/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/4) Glycosyl hydrolases family 2
PF00232 (4/4) Glycosyl hydrolase family 1
PF13977 (2/4) BetI-type transcriptional repressor, C-terminal
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF00440 (2/4) Bacterial regulatory proteins, tetR family
jaccard_groups_3589 19.57 +- 2.66 4 0 0 0 0.19 +- 0.26 4 13

TIGR01031 (4/4) ribosomal protein bL32
PF07683 (4/4) Cobalamin synthesis protein cobW C-terminal domain
PF02492 (4/4) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (4/4) Ribosomal L32p protein family
PF13229 (3/4) Right handed beta helix region
PF07602 (3/4) Protein of unknown function (DUF1565)
PF04341 (3/4) Protein of unknown function, DUF485
PF00474 (3/4) Sodium:solute symporter family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
TIGR03558 (2/4) luciferase family oxidoreductase, group 1
PF08031 (2/4) Berberine and berberine like
PF01565 (2/4) FAD binding domain
PF00296 (2/4) Luciferase-like monooxygenase
jaccard_groups_3588 391.48 +- 205.18 6 0 2 0 0.03 +- 0.10 6 6

PF13535 (6/6) ATP-grasp domain
PF07690 (6/6) Major Facilitator Superfamily
PF06368 (6/6) Methylaspartate mutase E chain (MutE)
PF02310 (6/6) B12 binding domain
PF01613 (6/6) Flavin reductase like domain
PF00296 (6/6) Luciferase-like monooxygenase
jaccard_groups_3583 186.23 +- 147.00 3 0 1 0 0.04 +- 0.10 3 4

PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01494 (3/3) FAD binding domain
PF00797 (2/3) N-acetyltransferase
jaccard_groups_3587 157.42 +- 93.51 5 0 0 0 0.04 +- 0.08 5 5

PF06628 (5/5) Catalase-related immune-responsive
PF01475 (5/5) Ferric uptake regulator family
PF00248 (5/5) Aldo/keto reductase family
PF00199 (5/5) Catalase
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
jaccard_groups_1920 35.00 +- 26.00 4 0 1 0 0.16 +- 0.12 4 6

PF13377 (4/4) Periplasmic binding protein-like domain
PF01670 (4/4) Glycosyl hydrolase family 12
PF00553 (4/4) Cellulose binding domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF03067 (3/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF17648 (2/4) Family of unknown function (DUF5519)
jaccard_groups_655 69.47 +- 59.69 20 0 1 0 0.18 +- 0.24 20 7

PF13510 (20/20) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (20/20) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (20/20) BFD-like [2Fe-2S] binding domain
PF01266 (20/20) FAD dependent oxidoreductase
PF00701 (20/20) Dihydrodipicolinate synthetase family
PF05544 (17/20) Proline racemase
PF02423 (12/20) Ornithine cyclodeaminase/mu-crystallin family
jaccard_groups_654 147.20 +- 112.80 2 0 1 0 0.03 +- 0.04 2 3

PF01804 (2/2) Penicillin amidase
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_656 40.73 +- 26.37 8 0 0 0 0.08 +- 0.09 8 3

PF03061 (8/8) Thioesterase superfamily
TIGR00369 (7/8) uncharacterized domain 1
PF01638 (4/8) HxlR-like helix-turn-helix
jaccard_groups_651 17.90 +- 1.36 2 0 1 0 0.19 +- 0.30 2 8

TIGR01413 (2/2) Dyp-type peroxidase family
TIGR00873 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF04261 (2/2) Dyp-type peroxidase family
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF04454 (1/2) Encapsulating protein for peroxidase
jaccard_groups_652 334.15 +- 212.21 2 0 0 0 0.08 +- 0.21 2 23

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF14525 (1/2) AraC-binding-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12833 (1/2) Helix-turn-helix domain
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07883 (1/2) Cupin domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02803 (1/2) Thiolase, C-terminal domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02515 (1/2) CoA-transferase family III
PF01039 (1/2) Carboxyl transferase domain
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00364 (1/2) Biotin-requiring enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00285 (1/2) Citrate synthase, C-terminal domain
PF00108 (1/2) Thiolase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_1437 11.79 +- 3.07 14 0 0 0 0.18 +- 0.37 14 4

TIGR00737 (14/14) putative TIM-barrel protein, nifR3 family
PF06386 (14/14) Gas vesicle synthesis protein GvpL/GvpF
PF03364 (14/14) Polyketide cyclase / dehydrase and lipid transport
PF01207 (14/14) Dihydrouridine synthase (Dus)
jaccard_groups_5041 1877.33 +- 808.40 3 0 0 0 0.01 +- 0.01 3 28

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
TIGR00481 (3/3) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF14765 (3/3) Polyketide synthase dehydratase
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF12697 (3/3) Alpha/beta hydrolase family
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF08659 (3/3) KR domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF06684 (3/3) Amino acid synthesis
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01614 (3/3) Bacterial transcriptional regulator
PF01554 (3/3) MatE
PF01494 (3/3) FAD binding domain
PF01161 (3/3) Phosphatidylethanolamine-binding protein
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
jaccard_groups_659 161.89 +- 278.13 12 0 3 1 0.08 +- 0.13 12 2

TIGR00027 (12/12) methyltransferase, TIGR00027 family
PF04072 (12/12) Leucine carboxyl methyltransferase
jaccard_groups_2368 96.60 +- 26.24 7 0 1 0 0.04 +- 0.02 7 6

PF12697 (7/7) Alpha/beta hydrolase family
PF06684 (7/7) Amino acid synthesis
PF00296 (7/7) Luciferase-like monooxygenase
PF00171 (7/7) Aldehyde dehydrogenase family
PF07729 (6/7) FCD domain
PF00392 (6/7) Bacterial regulatory proteins, gntR family
jaccard_groups_1927 390.99 +- 240.66 4 0 0 0 0.04 +- 0.03 4 12

PF16861 (4/4) Carbamoyltransferase C-terminus
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08241 (4/4) Methyltransferase domain
PF02543 (4/4) Carbamoyltransferase N-terminus
PF02348 (4/4) Cytidylyltransferase
PF01636 (4/4) Phosphotransferase enzyme family
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00670 (4/4) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00303 (4/4) Thymidylate synthase
PF00300 (4/4) Histidine phosphatase superfamily (branch 1)
PF00293 (4/4) NUDIX domain
TIGR01549 (3/4) HAD hydrolase, family IA, variant 1
jaccard_groups_6333 498.95 +- 269.23 2 0 2 2 0.04 +- 0.05 2 17

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF08281 (2/2) Sigma-70, region 4
PF08241 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04542 (2/2) Sigma-70 region 2
PF01661 (2/2) Macro domain
PF01129 (2/2) NAD:arginine ADP-ribosyltransferase
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00881 (2/2) Nitroreductase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
jaccard_groups_3769 185.06 +- 130.17 4 0 4 0 0.06 +- 0.20 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF02897 (4/4) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (4/4) Prolyl oligopeptidase family
PF00313 (4/4) 'Cold-shock' DNA-binding domain
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00069 (4/4) Protein kinase domain
jaccard_groups_2360 116.32 +- 78.61 6 0 0 0 0.05 +- 0.08 6 7

PF12833 (6/6) Helix-turn-helix domain
PF08545 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (6/6) DJ-1/PfpI family
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_2361 287.77 +- 218.14 15 0 0 0 0.04 +- 0.04 15 8

TIGR01821 (15/15) 5-aminolevulinic acid synthase
PF07690 (15/15) Major Facilitator Superfamily
PF03466 (15/15) LysR substrate binding domain
PF01408 (15/15) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (15/15) Acetyltransferase (GNAT) family
PF00155 (15/15) Aminotransferase class I and II
PF00126 (15/15) Bacterial regulatory helix-turn-helix protein, lysR family
PF06224 (14/15) Winged helix DNA-binding domain
jaccard_groups_2961 369.33 +- 273.36 9 0 0 0 0.01 +- 0.00 9 9

PF17390 (9/9) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (9/9) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (9/9) Alpha-L-rhamnosidase N-terminal domain
PF05592 (9/9) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF18310 (8/9) Domain of unknown function (DUF5605)
PF17851 (8/9) Beta xylosidase C-terminal Concanavalin A-like domain
PF16586 (8/9) Domain of unknown function (DUF5060)
PF13204 (8/9) Protein of unknown function (DUF4038)
PF04616 (8/9) Glycosyl hydrolases family 43
jaccard_groups_2746 121.05 +- 44.91 10 0 0 0 0.10 +- 0.08 10 6

PF11975 (10/10) Family 4 glycosyl hydrolase C-terminal domain
PF02056 (10/10) Family 4 glycosyl hydrolase
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00294 (9/10) pfkB family carbohydrate kinase
PF03537 (5/10) Glycoside-hydrolase family GH114
jaccard_groups_2963 615.47 +- 545.53 2 0 2 0 0.07 +- 0.20 2 14

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF03621 (2/2) MbtH-like protein
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00697 (2/2) N-(5'phosphoribosyl)anthranilate (PRA) isomerase
PF00591 (2/2) Glycosyl transferase family, a/b domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
jaccard_groups_6427 42.67 +- 14.67 2 0 0 0 0.11 +- 0.18 2 5

PF16670 (2/2) Phosphoinositide phospholipase C, Ca2+-dependent
PF13751 (2/2) Transposase DDE domain
PF13655 (2/2) N-terminal domain of reverse transcriptase
PF03795 (2/2) YCII-related domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_2743 14.48 +- 2.31 6 0 0 0 0.21 +- 0.21 6 8

TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13589 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13483 (6/6) Beta-lactamase superfamily domain
PF04075 (6/6) F420H(2)-dependent quinone reductase
PF01738 (6/6) Dienelactone hydrolase family
PF00355 (6/6) Rieske [2Fe-2S] domain
PF00183 (6/6) Hsp90 protein
PF09490 (5/6) Probable cobalt transporter subunit (CbtA)
jaccard_groups_2968 237.30 +- 29.18 3 0 3 0 0.01 +- 0.00 3 6

TIGR01926 (3/3) uncharacterized peroxidase-related enzyme
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF07690 (3/3) Major Facilitator Superfamily
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00106 (3/3) short chain dehydrogenase
jaccard_groups_6428 273.00 +- 117.00 2 0 0 0 0.01 +- 0.01 2 5

PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00962 (2/2) Adenosine/AMP deaminase
PF13377 (1/2) Periplasmic binding protein-like domain
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_496 140.37 +- 130.76 4 0 0 0 0.12 +- 0.19 4 4

PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain
TIGR01788 (2/4) glutamate decarboxylase
PF13328 (2/4) HD domain
PF01909 (2/4) Nucleotidyltransferase domain
jaccard_groups_495 50.66 +- 79.52 9 0 3 0 0.14 +- 0.22 9 1

PF00294 (9/9) pfkB family carbohydrate kinase
jaccard_groups_494 66.46 +- 46.45 156 0 7 0 0.15 +- 0.18 156 6

TIGR00996 (156/156) virulence factor Mce family protein
PF11887 (156/156) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (156/156) MlaD protein
PF02405 (156/156) Permease MlaE
PF00005 (156/156) ABC transporter
PF13406 (115/156) Transglycosylase SLT domain
jaccard_groups_493 53.25 +- 19.48 4 0 0 0 0.06 +- 0.06 4 4

PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (3/4) Peptidase family M23
PF00583 (2/4) Acetyltransferase (GNAT) family
jaccard_groups_492 162.57 +- 122.86 22 0 4 0 0.04 +- 0.08 22 2

PF06013 (22/22) Proteins of 100 residues with WXG
TIGR03930 (16/22) WXG100 family type VII secretion target
jaccard_groups_491 620.80 +- 206.61 5 0 0 0 0.01 +- 0.00 5 4

TIGR01473 (5/5) protoheme IX farnesyltransferase
PF04261 (5/5) Dyp-type peroxidase family
PF01040 (5/5) UbiA prenyltransferase family
TIGR01413 (3/5) Dyp-type peroxidase family
jaccard_groups_2569 203.93 +- 40.37 4 0 0 2 0.06 +- 0.12 4 8

PF07690 (4/4) Major Facilitator Superfamily
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF05726 (3/4) Pirin C-terminal cupin domain
PF02678 (3/4) Pirin
PF14246 (2/4) AefR-like transcriptional repressor, C-terminal domain
PF04055 (2/4) Radical SAM superfamily
PF02668 (2/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01494 (2/4) FAD binding domain
jaccard_groups_2565 345.37 +- 304.63 2 0 0 0 0.02 +- 0.03 2 6

PF00082 (2/2) Subtilase family
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13191 (1/2) AAA ATPase domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03704 (1/2) Bacterial transcriptional activator domain
jaccard_groups_2566 126.39 +- 94.33 5 0 0 0 0.16 +- 0.30 5 10

PF05331 (5/5) Protein of unknown function (DUF742)
PF04472 (5/5) Cell division protein SepF
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF13416 (4/5) Bacterial extracellular solute-binding protein
PF12643 (4/5) MazG-like family
jaccard_groups_2560 92.26 +- 40.07 6 0 0 0 0.06 +- 0.07 6 11

TIGR01930 (6/6) acetyl-CoA C-acyltransferase
TIGR01509 (6/6) HAD hydrolase, family IA, variant 3
PF13419 (6/6) Haloacid dehalogenase-like hydrolase
PF02803 (6/6) Thiolase, C-terminal domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00108 (6/6) Thiolase, N-terminal domain
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain
PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain
PF13561 (3/6) Enoyl-(Acyl carrier protein) reductase
PF00106 (3/6) short chain dehydrogenase
jaccard_groups_2561 71.60 +- 23.75 4 0 1 0 0.04 +- 0.03 4 5

PF12802 (4/4) MarR family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
PF00107 (4/4) Zinc-binding dehydrogenase
PF05368 (3/4) NmrA-like family
jaccard_groups_2562 58.37 +- 22.12 8 0 2 0 0.06 +- 0.07 8 3

PF11512 (7/8) Agrobacterium tumefaciens protein Atu4866
PF07690 (7/8) Major Facilitator Superfamily
PF01979 (7/8) Amidohydrolase family
jaccard_groups_5219 51.76 +- 6.54 2 0 0 0 0.16 +- 0.22 2 21

TIGR02635 (2/2) L-rhamnose isomerase
TIGR02632 (2/2) rhamnulose-1-phosphate aldolase/alcohol dehydrogenase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03777 (2/2) ChpA-C
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00202 (2/2) Aminotransferase class-III
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
TIGR00879 (1/2) MFS transporter, sugar porter (SP) family
PF12697 (1/2) Alpha/beta hydrolase family
PF06134 (1/2) L-rhamnose isomerase (RhaA)
PF03479 (1/2) Plants and Prokaryotes Conserved (PCC) domain
PF00210 (1/2) Ferritin-like domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_5214 158.26 +- 16.25 3 0 0 0 0.08 +- 0.07 3 19

PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF06831 (3/3) Formamidopyrimidine-DNA glycosylase H2TH domain
PF06827 (3/3) Zinc finger found in FPG and IleRS
PF05425 (3/3) Copper resistance protein D
PF04234 (3/3) CopC domain
PF02449 (3/3) Beta-galactosidase
PF02342 (3/3) TerD domain
PF02065 (3/3) Melibiase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01149 (3/3) Formamidopyrimidine-DNA glycosylase N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00440 (3/3) Bacterial regulatory proteins, tetR family
TIGR00229 (2/3) PAS domain S-box protein
PF13581 (2/3) Histidine kinase-like ATPase domain
PF08448 (2/3) PAS fold
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF01590 (2/3) GAF domain
PF00989 (2/3) PAS fold
jaccard_groups_788 101.62 +- 112.97 9 0 0 0 0.14 +- 0.23 9 2

PF02826 (9/9) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (5/9) Cellulose binding domain
jaccard_groups_5501 65.11 +- 20.89 2 0 2 0 0.13 +- 0.24 2 9

PF18029 (2/2) Glyoxalase-like domain
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05401 (2/2) Nodulation protein S (NodS)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00107 (2/2) Zinc-binding dehydrogenase
PF01276 (1/2) Orn/Lys/Arg decarboxylase, major domain
jaccard_groups_783 209.99 +- 98.03 5 0 1 0 0.03 +- 0.08 5 2

PF03364 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF01814 (4/5) Hemerythrin HHE cation binding domain
jaccard_groups_785 323.50 +- 63.50 2 0 0 0 0.01 +- 0.00 2 3

PF13396 (2/2) Phospholipase_D-nuclease N-terminal
PF11139 (2/2) Sap, sulfolipid-1-addressing protein
PF09851 (2/2) Short C-terminal domain
jaccard_groups_784 112.93 +- 105.74 6 0 1 0 0.06 +- 0.10 6 2

PF09995 (6/6) Uncharacterized protein conserved in bacteria (DUF2236)
PF00171 (5/6) Aldehyde dehydrogenase family
jaccard_groups_5696 242.21 +- 34.21 2 0 0 0 0.02 +- 0.03 2 10

TIGR01505 (2/2) 2-hydroxy-3-oxopropionate reductase
PF14871 (2/2) Hypothetical glycosyl hydrolase 6
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13183 (2/2) 4Fe-4S dicluster domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02754 (2/2) Cysteine-rich domain
PF01565 (2/2) FAD binding domain
PF13358 (1/2) DDE superfamily endonuclease
jaccard_groups_5695 394.68 +- 74.41 2 0 0 0 0.02 +- 0.02 2 12

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09339 (2/2) IclR helix-turn-helix domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07080 (2/2) Protein of unknown function (DUF1348)
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_5694 68.53 +- 4.03 2 0 0 0 0.04 +- 0.03 2 5

PF17479 (2/2) Protein of unknown function (DUF3048) C-terminal domain
PF13411 (2/2) MerR HTH family regulatory protein
PF11258 (2/2) Protein of unknown function (DUF3048) N-terminal domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_5690 15.80 +- 3.70 2 0 0 0 0.21 +- 0.21 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04341 (2/2) Protein of unknown function, DUF485
PF04029 (2/2) 2-phosphosulpholactate phosphatase
PF00474 (2/2) Sodium:solute symporter family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF18029 (1/2) Glyoxalase-like domain
jaccard_groups_2411 560.20 +- 253.90 5 0 5 0 0.01 +- 0.01 5 8

PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (5/5) Transketolase, C-terminal domain
PF02779 (5/5) Transketolase, pyrimidine binding domain
PF00676 (5/5) Dehydrogenase E1 component
PF00364 (5/5) Biotin-requiring enzyme
PF00550 (3/5) Phosphopantetheine attachment site
PF00107 (3/5) Zinc-binding dehydrogenase
jaccard_groups_2413 1917.88 +- 1471.87 14 7 6 14 0.03 +- 0.08 7 7

TIGR03605 (14/14) SagB-type dehydrogenase domain
PF02624 (14/14) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (14/14) Nitroreductase family
PF00005 (14/14) ABC transporter
TIGR03604 (11/14) thiazole/oxazole-forming peptide maturase, SagD family component
PF02517 (11/14) CPBP intramembrane metalloprotease
PF01061 (9/14) ABC-2 type transporter
jaccard_groups_2414 117.82 +- 52.23 14 0 3 0 0.06 +- 0.07 14 12

TIGR03945 (14/14) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (14/14) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (14/14) benzoate transporter
PF13454 (14/14) FAD-NAD(P)-binding
PF03594 (14/14) Benzoate membrane transport protein
PF02423 (14/14) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (14/14) Cys/Met metabolism PLP-dependent enzyme
PF00291 (14/14) Pyridoxal-phosphate dependent enzyme
TIGR01891 (7/14) amidohydrolase
PF13424 (7/14) Tetratricopeptide repeat
PF01546 (7/14) Peptidase family M20/M25/M40
PF00931 (7/14) NB-ARC domain
jaccard_groups_2419 424.00 +- 741.20 13 0 13 0 0.14 +- 0.26 13 19

TIGR01733 (13/13) amino acid adenylation domain
PF13193 (13/13) AMP-binding enzyme C-terminal domain
PF02668 (13/13) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (13/13) Thioesterase domain
PF00550 (13/13) Phosphopantetheine attachment site
PF00501 (13/13) AMP-binding enzyme
TIGR03945 (11/13) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (11/13) 2,3-diaminopropionate biosynthesis protein SbnB
PF02423 (11/13) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (11/13) Pyridoxal-phosphate dependent enzyme
PF13561 (10/13) Enoyl-(Acyl carrier protein) reductase
TIGR01327 (9/13) phosphoglycerate dehydrogenase
PF04073 (9/13) Aminoacyl-tRNA editing domain
PF02826 (9/13) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02801 (9/13) Beta-ketoacyl synthase, C-terminal domain
PF01323 (9/13) DSBA-like thioredoxin domain
PF00109 (9/13) Beta-ketoacyl synthase, N-terminal domain
PF03621 (8/13) MbtH-like protein
PF00668 (7/13) Condensation domain
jaccard_groups_879 112.22 +- 170.00 18 0 3 0 0.10 +- 0.14 18 3

PF13309 (17/18) HTH domain
PF08348 (17/18) YheO-like PAS domain
PF00291 (14/18) Pyridoxal-phosphate dependent enzyme
jaccard_groups_878 177.39 +- 374.10 25 0 0 0 0.13 +- 0.17 25 3

PF00482 (25/25) Type II secretion system (T2SS), protein F
PF14029 (24/25) Protein of unknown function (DUF4244)
PF07811 (17/25) TadE-like protein
jaccard_groups_6403 65.49 +- 10.34 2 0 0 0 0.19 +- 0.20 2 5

PF14273 (2/2) Domain of unknown function (DUF4360)
PF14016 (2/2) Protein of unknown function (DUF4232)
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01925 (2/2) Sulfite exporter TauE/SafE
jaccard_groups_877 42.23 +- 16.41 15 0 15 0 0.18 +- 0.30 15 5

PF17964 (15/15) Bacterial Ig domain
PF13499 (15/15) EF-hand domain pair
PF05425 (15/15) Copper resistance protein D
PF03734 (15/15) L,D-transpeptidase catalytic domain
PF01522 (14/15) Polysaccharide deacetylase
jaccard_groups_873 47.05 +- 11.67 3 0 0 0 0.20 +- 0.37 3 12

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (3/3) YD repeat (two copies)
TIGR00613 (3/3) DNA repair protein RecO
TIGR00055 (3/3) di-trans,poly-cis-decaprenylcistransferase
PF13560 (3/3) Helix-turn-helix domain
PF11967 (3/3) Recombination protein O N terminal
PF05593 (3/3) RHS Repeat
PF04149 (3/3) Domain of unknown function (DUF397)
PF02565 (3/3) Recombination protein O C terminal
PF01255 (3/3) Putative undecaprenyl diphosphate synthase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00106 (3/3) short chain dehydrogenase
jaccard_groups_1262 25.80 +- 8.60 47 0 6 0 0.14 +- 0.06 47 4

TIGR01691 (47/47) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (47/47) ARD/ARD' family
PF00596 (46/47) Class II Aldolase and Adducin N-terminal domain
TIGR03328 (44/47) methylthioribulose-1-phosphate dehydratase
jaccard_groups_5032 127.43 +- 19.00 3 0 0 3 0.13 +- 0.18 3 9

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF01494 (3/3) FAD binding domain
PF00881 (3/3) Nitroreductase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
jaccard_groups_5030 138.08 +- 52.89 3 0 3 0 0.10 +- 0.26 3 19

TIGR03026 (3/3) nucleotide sugar dehydrogenase
TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF07730 (3/3) Histidine kinase
PF07690 (3/3) Major Facilitator Superfamily
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF01266 (3/3) FAD dependent oxidoreductase
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF08990 (2/3) Erythronolide synthase docking
jaccard_groups_5037 351.80 +- 235.05 3 0 3 0 0.07 +- 0.23 3 7

PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF03949 (3/3) Malic enzyme, NAD binding domain
PF00975 (3/3) Thioesterase domain
PF00390 (3/3) Malic enzyme, N-terminal domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
jaccard_groups_1264 388.00 +- 128.00 2 0 2 0 0.01 +- 0.00 2 4

TIGR00236 (2/2) UDP-N-acetylglucosamine 2-epimerase
PF02350 (2/2) UDP-N-acetylglucosamine 2-epimerase
PF01436 (1/2) NHL repeat
PF00069 (1/2) Protein kinase domain
jaccard_groups_3030 98.97 +- 47.94 4 0 2 0 0.08 +- 0.17 4 9

PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01756 (4/4) Acyl-CoA oxidase
PF00550 (4/4) Phosphopantetheine attachment site
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF08545 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01497 (2/4) Periplasmic binding protein
PF00294 (2/4) pfkB family carbohydrate kinase
jaccard_groups_1268 84.19 +- 73.22 8 0 1 0 0.06 +- 0.05 8 3

PF00106 (8/8) short chain dehydrogenase
PF00743 (5/8) Flavin-binding monooxygenase-like
PF00171 (5/8) Aldehyde dehydrogenase family
jaccard_groups_285 388.50 +- 1.50 2 0 1 0 0.01 +- 0.00 2 6

PF10590 (2/2) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF04892 (1/2) VanZ like family
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF01209 (1/2) ubiE/COQ5 methyltransferase family
PF00557 (1/2) Metallopeptidase family M24
jaccard_groups_282 82.60 +- 80.68 3 0 0 0 0.08 +- 0.10 3 1

PF01613 (3/3) Flavin reductase like domain
jaccard_groups_2261 296.71 +- 144.47 11 0 0 9 0.03 +- 0.08 11 7

PF04828 (10/11) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (10/11) Amidinotransferase
PF00999 (9/11) Sodium/hydrogen exchanger family
PF00881 (9/11) Nitroreductase family
PF12981 (7/11) Domain of Unknown Function with PDB structure (DUF3865)
PF08007 (7/11) Cupin superfamily protein
PF00487 (7/11) Fatty acid desaturase
jaccard_groups_1197 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_1190 45.04 +- 45.26 20 0 0 0 0.13 +- 0.15 20 4

PF16157 (20/20) Domain of unknown function (DUF4865)
PF00440 (20/20) Bacterial regulatory proteins, tetR family
PF02126 (19/20) Phosphotriesterase family
PF07883 (16/20) Cupin domain
jaccard_groups_280 222.88 +- 423.94 6 0 0 0 0.11 +- 0.13 6 8

TIGR03925 (6/6) type VII secretion protein EccCb
TIGR03924 (6/6) type VII secretion protein EccCa
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF01580 (6/6) FtsK/SpoIIIE family
TIGR03920 (5/6) type VII secretion integral membrane protein EccD
PF01656 (5/6) CobQ/CobB/MinD/ParA nucleotide binding domain
PF13556 (3/6) PucR C-terminal helix-turn-helix domain
PF07905 (3/6) Purine catabolism regulatory protein-like family
jaccard_groups_6065 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_281 164.73 +- 100.49 8 0 1 0 0.03 +- 0.05 8 3

PF00553 (8/8) Cellulose binding domain
PF01341 (4/8) Glycosyl hydrolases family 6
PF00331 (4/8) Glycosyl hydrolase family 10
jaccard_groups_1198 439.90 +- 389.68 37 0 32 0 0.05 +- 0.15 37 11

PF18603 (37/37) L-amino acid ligase C-terminal domain 2
PF13535 (37/37) ATP-grasp domain
PF00501 (37/37) AMP-binding enzyme
PF00291 (37/37) Pyridoxal-phosphate dependent enzyme
PF00206 (36/37) Lyase
TIGR01733 (32/37) amino acid adenylation domain
PF00550 (32/37) Phosphopantetheine attachment site
PF13193 (31/37) AMP-binding enzyme C-terminal domain
PF18130 (30/37) ATP-grasp N-terminal domain
PF00975 (30/37) Thioesterase domain
PF00288 (30/37) GHMP kinases N terminal domain
jaccard_groups_1868 30.35 +- 7.95 9 0 0 0 0.11 +- 0.12 9 2

PF07690 (9/9) Major Facilitator Superfamily
PF00291 (9/9) Pyridoxal-phosphate dependent enzyme
jaccard_groups_1869 385.39 +- 304.04 23 0 9 0 0.06 +- 0.03 23 17

PF02801 (23/23) Beta-ketoacyl synthase, C-terminal domain
PF00109 (23/23) Beta-ketoacyl synthase, N-terminal domain
PF00005 (22/23) ABC transporter
PF08545 (21/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (21/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00106 (21/23) short chain dehydrogenase
PF01144 (20/23) Coenzyme A transferase
PF00378 (20/23) Enoyl-CoA hydratase/isomerase
PF13561 (19/23) Enoyl-(Acyl carrier protein) reductase
PF00196 (19/23) Bacterial regulatory proteins, luxR family
PF12679 (14/23) ABC-2 family transporter protein
TIGR00976 (13/23) hydrolase CocE/NonD family protein
PF13193 (13/23) AMP-binding enzyme C-terminal domain
PF08530 (13/23) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (13/23) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (13/23) AMP-binding enzyme
PF04909 (12/23) Amidohydrolase
jaccard_groups_129 52.39 +- 25.19 3 0 0 0 0.07 +- 0.06 3 4

PF13333 (3/3) Integrase core domain
PF13276 (3/3) HTH-like domain
PF01527 (3/3) Transposase
PF00665 (3/3) Integrase core domain
jaccard_groups_128 101.26 +- 95.75 18 0 3 0 0.06 +- 0.09 18 1

PF01872 (18/18) RibD C-terminal domain
jaccard_groups_127 195.80 +- 78.00 8 0 0 0 0.02 +- 0.05 8 5

TIGR01549 (8/8) HAD hydrolase, family IA, variant 1
PF13419 (8/8) Haloacid dehalogenase-like hydrolase
PF01557 (4/8) Fumarylacetoacetate (FAA) hydrolase family
PF00392 (4/8) Bacterial regulatory proteins, gntR family
PF00155 (4/8) Aminotransferase class I and II
jaccard_groups_126 48.31 +- 61.39 11 0 0 0 0.10 +- 0.09 11 1

PF00903 (11/11) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_125 86.15 +- 81.68 44 0 7 0 0.19 +- 0.27 44 4

TIGR01726 (44/44) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (44/44) Binding-protein-dependent transport system inner membrane component
PF00497 (44/44) Bacterial extracellular solute-binding proteins, family 3
PF00005 (43/44) ABC transporter
jaccard_groups_1864 150.31 +- 81.89 2 0 0 0 0.08 +- 0.08 2 12

TIGR01274 (2/2) 1-aminocyclopropane-1-carboxylate deaminase
PF13377 (2/2) Periplasmic binding protein-like domain
PF07729 (2/2) FCD domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF14528 (1/2) LAGLIDADG-like domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF02522 (1/2) Aminoglycoside 3-N-acetyltransferase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_122 183.77 +- 157.07 13 0 2 0 0.09 +- 0.12 13 2

PF11706 (13/13) CGNR zinc finger
PF07336 (13/13) Putative stress-induced transcription regulator
jaccard_groups_121 12.29 +- 4.25 5 0 1 0 0.19 +- 0.31 5 2

TIGR03445 (5/5) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF02585 (5/5) GlcNAc-PI de-N-acetylase
jaccard_groups_5034 133.74 +- 6.33 3 0 0 0 0.13 +- 0.29 3 12

PF16925 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14534 (3/3) Domain of unknown function (DUF4440)
PF13602 (3/3) Zinc-binding dehydrogenase
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13160 (3/3) Protein of unknown function (DUF3995)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF05195 (3/3) Aminopeptidase P, N-terminal domain
PF04951 (3/3) D-aminopeptidase
PF00557 (3/3) Metallopeptidase family M24
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
jaccard_groups_1465 132.78 +- 149.51 37 0 16 0 0.07 +- 0.08 37 5

PF05893 (37/37) Acyl-CoA reductase (LuxC)
PF04443 (37/37) Acyl-protein synthetase, LuxE
PF00583 (33/37) Acetyltransferase (GNAT) family
PF00501 (31/37) AMP-binding enzyme
PF07690 (28/37) Major Facilitator Superfamily
jaccard_groups_1462 24.37 +- 3.16 3 0 0 0 0.20 +- 0.11 3 3

TIGR00500 (3/3) methionine aminopeptidase, type I
PF02031 (3/3) Streptomyces extracellular neutral proteinase (M7) family
PF00557 (3/3) Metallopeptidase family M24
jaccard_groups_4125 23.10 +- 1.60 2 0 0 0 0.13 +- 0.15 2 5

TIGR00127 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13581 (2/2) Histidine kinase-like ATPase domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00484 (2/2) Carbonic anhydrase
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
jaccard_groups_1998 97.91 +- 20.03 2 0 0 0 0.04 +- 0.01 2 6

PF14063 (2/2) Protein of unknown function (DUF4254)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain
jaccard_groups_3828 2101.96 +- 1163.07 4 0 4 0 0.04 +- 0.10 4 29

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01444 (4/4) methyltransferase, FkbM family
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07977 (4/4) FabA-like domain
PF05977 (4/4) Transmembrane secretion effector
PF05050 (4/4) Methyltransferase FkbM domain
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02729 (4/4) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01323 (4/4) DSBA-like thioredoxin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00185 (4/4) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (4/4) Beta-lactamase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_1995 34.04 +- 19.19 5 0 1 0 0.08 +- 0.11 5 5

TIGR02608 (4/5) delta-60 repeat domain
PF17164 (4/5) Domain of unknown function (DUF5122) beta-propeller
PF00353 (4/5) RTX calcium-binding nonapeptide repeat (4 copies)
TIGR01451 (3/5) conserved repeat domain
PF02811 (3/5) PHP domain
jaccard_groups_1996 263.90 +- 270.50 21 0 3 0 0.08 +- 0.11 21 6

TIGR01972 (21/21) proton-translocating NADH-quinone oxidoreductase, chain M
PF00507 (21/21) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (21/21) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (21/21) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (21/21) Proton-conducting membrane transporter
PF00146 (21/21) NADH dehydrogenase
jaccard_groups_1991 72.10 +- 40.50 19 0 19 0 0.15 +- 0.31 19 9

TIGR02406 (19/19) diaminobutyrate acetyltransferase
TIGR00556 (19/19) phosphopantetheine--protein transferase domain
PF13193 (19/19) AMP-binding enzyme C-terminal domain
PF06339 (19/19) Ectoine synthase
PF02784 (19/19) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (19/19) 4'-phosphopantetheinyl transferase superfamily
PF00583 (19/19) Acetyltransferase (GNAT) family
PF00501 (19/19) AMP-binding enzyme
PF00550 (18/19) Phosphopantetheine attachment site
jaccard_groups_4496 230.33 +- 112.90 3 0 3 0 0.02 +- 0.01 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13483 (3/3) Beta-lactamase superfamily domain
PF07467 (3/3) Beta-lactamase inhibitor (BLIP)
PF04989 (3/3) Cephalosporin hydroxylase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
jaccard_groups_4497 52.71 +- 20.33 4 0 1 0 0.06 +- 0.04 4 6

PF12840 (4/4) Helix-turn-helix domain
PF00581 (4/4) Rhodanese-like domain
PF00266 (4/4) Aminotransferase class-V
PF07690 (2/4) Major Facilitator Superfamily
PF01206 (2/4) Sulfurtransferase TusA
PF01053 (2/4) Cys/Met metabolism PLP-dependent enzyme
jaccard_groups_4494 174.89 +- 75.80 4 0 4 0 0.04 +- 0.10 4 8

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13577 (4/4) SnoaL-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF06902 (4/4) Divergent 4Fe-4S mono-cluster
PF04673 (4/4) Polyketide synthesis cyclase
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
jaccard_groups_1518 117.84 +- 44.31 3 0 0 0 0.03 +- 0.03 3 2

PF09948 (3/3) Predicted metal-binding integral membrane protein (DUF2182)
PF07040 (3/3) Protein of unknown function (DUF1326)
jaccard_groups_1519 31.80 +- 24.92 8 0 0 0 0.17 +- 0.26 8 8

TIGR00589 (8/8) methylated-DNA--[protein]-cysteine S-methyltransferase
PF13532 (8/8) 2OG-Fe(II) oxygenase superfamily
PF12728 (8/8) Helix-turn-helix domain
PF01035 (8/8) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF04461 (7/8) Protein of unknown function (DUF520)
PF00589 (6/8) Phage integrase family
PF12307 (5/8) Protein of unknown function (DUF3631)
PF09250 (5/8) Bifunctional DNA primase/polymerase, N-terminal
jaccard_groups_1049 57.01 +- 11.79 2 0 1 0 0.04 +- 0.03 2 4

PF14042 (2/2) Domain of unknown function (DUF4247)
PF10936 (2/2) Protein of unknown function DUF2617
PF03994 (2/2) Domain of Unknown Function (DUF350)
PF01564 (2/2) Spermine/spermidine synthase domain
jaccard_groups_3568 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase
jaccard_groups_1042 28.62 +- 13.60 8 0 4 0 0.17 +- 0.17 8 8

PF02836 (8/8) Glycosyl hydrolases family 2, TIM barrel domain
PF00754 (8/8) F5/8 type C domain
PF09362 (7/8) Domain of unknown function (DUF1996)
PF14310 (6/8) Fibronectin type III-like domain
PF01915 (6/8) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (6/8) Glycosyl hydrolase family 3 N terminal domain
PF13377 (5/8) Periplasmic binding protein-like domain
PF00356 (5/8) Bacterial regulatory proteins, lacI family
jaccard_groups_1512 63.57 +- 23.26 10 0 0 0 0.05 +- 0.05 10 5

PF16259 (10/10) Domain of unknown function (DUF4913)
PF12696 (10/10) TraM recognition site of TraD and TraG
PF02882 (10/10) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01425 (10/10) Amidase
PF00763 (10/10) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
jaccard_groups_1041 62.11 +- 21.45 11 0 0 0 0.14 +- 0.28 11 14

TIGR01389 (11/11) ATP-dependent DNA helicase RecQ
PF16124 (11/11) RecQ zinc-binding
PF09382 (11/11) RQC domain
PF00570 (11/11) HRDC domain
PF00271 (11/11) Helicase conserved C-terminal domain
PF00270 (11/11) DEAD/DEAH box helicase
TIGR03796 (10/11) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF03412 (10/11) Peptidase C39 family
PF00664 (10/11) ABC transporter transmembrane region
PF00005 (10/11) ABC transporter
TIGR03797 (9/11) NHLM bacteriocin system ABC transporter, ATP-binding protein
PF13437 (9/11) HlyD family secretion protein
PF13545 (7/11) Crp-like helix-turn-helix domain
PF00027 (7/11) Cyclic nucleotide-binding domain
jaccard_groups_1046 621.58 +- 823.10 73 0 73 73 0.04 +- 0.06 73 9

TIGR03891 (73/73) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (73/73) Lantibiotic biosynthesis dehydratase C-term
PF05147 (73/73) Lanthionine synthetase C-like protein
PF04738 (73/73) Lantibiotic dehydratase, N terminus
PF00005 (72/73) ABC transporter
PF00296 (71/73) Luciferase-like monooxygenase
PF00196 (67/73) Bacterial regulatory proteins, luxR family
PF05139 (55/73) Erythromycin esterase
PF00392 (41/73) Bacterial regulatory proteins, gntR family
jaccard_groups_1044 23.17 +- 4.47 3 0 0 0 0.15 +- 0.21 3 5

PF16859 (3/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF08962 (2/3) Domain of unknown function (DUF1876)
PF04073 (2/3) Aminoacyl-tRNA editing domain
PF03176 (2/3) MMPL family
jaccard_groups_1045 228.31 +- 376.03 17 0 16 1 0.08 +- 0.16 17 11

TIGR01733 (17/17) amino acid adenylation domain
PF13193 (17/17) AMP-binding enzyme C-terminal domain
PF02423 (17/17) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (17/17) Phosphopantetheine attachment site
PF00501 (17/17) AMP-binding enzyme
TIGR03944 (16/17) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR03945 (12/17) 2,3-diaminopropionate biosynthesis protein SbnA
PF00291 (12/17) Pyridoxal-phosphate dependent enzyme
PF02668 (11/17) Taurine catabolism dioxygenase TauD, TfdA family
TIGR02353 (9/17) non-ribosomal peptide synthetase terminal domain of unknown function
PF00975 (9/17) Thioesterase domain
jaccard_groups_4013 87.54 +- 49.34 3 0 0 0 0.03 +- 0.04 3 3

PF13328 (3/3) HD domain
PF08962 (3/3) Domain of unknown function (DUF1876)
PF00069 (3/3) Protein kinase domain
jaccard_groups_4016 27.87 +- 13.97 3 0 0 0 0.10 +- 0.11 3 3

TIGR03696 (3/3) RHS repeat-associated core domain
PF04672 (3/3) S-adenosyl methyltransferase
PF01636 (3/3) Phosphotransferase enzyme family
jaccard_groups_4015 15.24 +- 2.68 3 0 0 0 0.15 +- 0.17 3 3

PF06983 (3/3) 3-demethylubiquinone-9 3-methyltransferase
PF06224 (3/3) Winged helix DNA-binding domain
PF03176 (2/3) MMPL family
jaccard_groups_1680 208.92 +- 387.07 25 0 0 0 0.09 +- 0.15 25 3

PF00082 (25/25) Subtilase family
PF05425 (24/25) Copper resistance protein D
PF02515 (24/25) CoA-transferase family III
jaccard_groups_1681 42.32 +- 45.89 5 0 1 0 0.14 +- 0.18 5 2

PF10604 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF01593 (3/5) Flavin containing amine oxidoreductase
jaccard_groups_4018 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
jaccard_groups_1685 117.78 +- 28.47 2 0 2 0 0.02 +- 0.02 2 6

PF18741 (2/2) REase_MTES_1575
PF13545 (2/2) Crp-like helix-turn-helix domain
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02342 (2/2) TerD domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_306 27.85 +- 14.19 5 0 0 0 0.11 +- 0.09 5 4

PF13361 (5/5) UvrD-like helicase C-terminal domain
PF13245 (5/5) AAA domain
PF04264 (5/5) YceI-like domain
PF00069 (5/5) Protein kinase domain
jaccard_groups_3911 147.94 +- 122.49 4 0 0 0 0.08 +- 0.18 4 10

TIGR02810 (4/4) D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
TIGR00167 (4/4) ketose-bisphosphate aldolase
PF08013 (4/4) Tagatose 6 phosphate kinase
PF01869 (4/4) BadF/BadG/BcrA/BcrD ATPase family
PF01380 (4/4) SIS domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00892 (4/4) EamA-like transporter family
TIGR02815 (3/4) putative sugar isomerase, AgaS family
PF07702 (3/4) UTRA domain
PF00392 (3/4) Bacterial regulatory proteins, gntR family
jaccard_groups_303 31.77 +- 13.15 3 0 0 0 0.17 +- 0.28 3 6

TIGR00649 (3/3) beta-CASP ribonuclease, RNase J family
PF17770 (3/3) Ribonuclease J C-terminal domain
PF07521 (3/3) Zn-dependent metallo-hydrolase RNA specificity domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF07690 (2/3) Major Facilitator Superfamily
PF00296 (2/3) Luciferase-like monooxygenase
jaccard_groups_302 142.21 +- 214.73 14 0 1 0 0.06 +- 0.07 14 2

PF03446 (14/14) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00150 (7/14) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_3914 794.08 +- 253.14 5 0 1 5 0.01 +- 0.01 5 10

TIGR04467 (5/5) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (5/5) Methyltransferase domain
PF13480 (5/5) Acetyltransferase (GNAT) domain
PF13238 (5/5) AAA domain
PF04055 (5/5) Radical SAM superfamily
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (5/5) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00300 (5/5) Histidine phosphatase superfamily (branch 1)
jaccard_groups_300 1186.63 +- 2036.71 221 9 196 221 0.08 +- 0.13 212 9

PF02624 (221/221) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR03882 (219/221) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (216/221) thiazole/oxazole-forming peptide maturase, SagD family component
PF00881 (208/221) Nitroreductase family
PF14028 (203/221) Lantibiotic biosynthesis dehydratase C-term
PF04738 (176/221) Lantibiotic dehydratase, N terminus
PF00005 (145/221) ABC transporter
TIGR03605 (139/221) SagB-type dehydrogenase domain
PF01061 (117/221) ABC-2 type transporter
jaccard_groups_4781 182.76 +- 33.91 2 0 0 0 0.02 +- 0.01 2 7

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
TIGR01451 (2/2) conserved repeat domain
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13489 (2/2) Methyltransferase domain
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF01345 (2/2) Domain of unknown function DUF11
jaccard_groups_309 59.57 +- 54.43 9 0 1 0 0.08 +- 0.11 9 2

PF00754 (8/9) F5/8 type C domain
PF00722 (6/9) Glycosyl hydrolases family 16
jaccard_groups_2863 48.97 +- 47.93 10 0 0 0 0.14 +- 0.29 10 10

PF17042 (10/10) Nucleotide-binding C-terminal domain
PF07729 (10/10) FCD domain
PF07005 (10/10) Sugar-binding N-terminal domain
PF01261 (10/10) Xylose isomerase-like TIM barrel
PF00596 (10/10) Class II Aldolase and Adducin N-terminal domain
PF00392 (10/10) Bacterial regulatory proteins, gntR family
PF00180 (10/10) Isocitrate/isopropylmalate dehydrogenase
TIGR01935 (8/10) RraA family
PF04332 (8/10) Protein of unknown function (DUF475)
PF03737 (8/10) Aldolase/RraA
jaccard_groups_4273 29.67 +- 4.84 4 0 0 0 0.11 +- 0.14 4 11

PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF12806 (4/4) Acetyl-CoA dehydrogenase C-terminal like
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00664 (4/4) ABC transporter transmembrane region
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (4/4) ABC transporter
PF12418 (3/4) Acyl-CoA dehydrogenase N terminal
PF08124 (3/4) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/4) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02771 (3/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02278 (3/4) Polysaccharide lyase family 8, super-sandwich domain
jaccard_groups_4270 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
jaccard_groups_1650 43.12 +- 23.04 11 0 0 0 0.18 +- 0.21 11 7

TIGR03718 (11/11) integral membrane protein, TerC family
PF05331 (11/11) Protein of unknown function (DUF742)
PF03741 (11/11) Integral membrane protein TerC family
PF03259 (11/11) Roadblock/LC7 domain
PF03029 (11/11) Conserved hypothetical ATP binding protein
PF00356 (9/11) Bacterial regulatory proteins, lacI family
PF18029 (8/11) Glyoxalase-like domain
jaccard_groups_4276 16.35 +- 1.24 2 0 0 0 0.19 +- 0.24 2 7

TIGR03173 (2/2) xanthine permease
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07702 (2/2) UTRA domain
PF00860 (2/2) Permease family
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13646 (1/2) HEAT repeats
jaccard_groups_4274 118.18 +- 51.61 4 0 0 0 0.04 +- 0.03 4 9

PF13377 (4/4) Periplasmic binding protein-like domain
PF08124 (4/4) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (4/4) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (4/4) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF17291 (3/4) N-terminal domain of M60-like peptidases
PF13402 (3/4) Peptidase M60, enhancin and enhancin-like
PF10022 (3/4) Uncharacterized protein conserved in bacteria (DUF2264)
PF02826 (3/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_4307 229.35 +- 53.17 4 0 0 0 0.02 +- 0.01 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF00455 (4/4) DeoR C terminal sensor domain
PF00359 (4/4) Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PF00027 (4/4) Cyclic nucleotide-binding domain
jaccard_groups_4304 15.62 +- 1.14 4 0 0 0 0.19 +- 0.26 4 6

PF14200 (4/4) Ricin-type beta-trefoil lectin domain-like
PF12833 (4/4) Helix-turn-helix domain
PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF01965 (4/4) DJ-1/PfpI family
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
PF00583 (4/4) Acetyltransferase (GNAT) family
jaccard_groups_4301 204.33 +- 114.42 4 0 1 0 0.07 +- 0.20 4 8

PF16884 (4/4) N-terminal domain of oxidoreductase
PF06441 (4/4) Epoxide hydrolase N terminus
PF00561 (4/4) alpha/beta hydrolase fold
PF00107 (4/4) Zinc-binding dehydrogenase
PF12146 (3/4) Serine aminopeptidase, S33
PF00106 (3/4) short chain dehydrogenase
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
jaccard_groups_4658 44.20 +- 14.04 3 0 1 0 0.20 +- 0.32 3 8

PF13560 (3/3) Helix-turn-helix domain
PF12833 (3/3) Helix-turn-helix domain
PF04672 (3/3) S-adenosyl methyltransferase
PF04149 (3/3) Domain of unknown function (DUF397)
PF00005 (3/3) ABC transporter
PF13377 (2/3) Periplasmic binding protein-like domain
PF09844 (2/3) Uncharacterized conserved protein (COG2071)
PF07690 (2/3) Major Facilitator Superfamily
jaccard_groups_4308 48.24 +- 8.93 2 0 0 0 0.05 +- 0.05 2 6

PF16259 (2/2) Domain of unknown function (DUF4913)
PF12696 (2/2) TraM recognition site of TraD and TraG
PF06414 (2/2) Zeta toxin
PF00534 (2/2) Glycosyl transferases group 1
PF13439 (1/2) Glycosyltransferase Family 4
PF01425 (1/2) Amidase
jaccard_groups_5116 459.00 +- 99.71 3 0 1 3 0.01 +- 0.00 3 10

TIGR03822 (3/3) lysine-2,3-aminomutase-related protein
PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF12697 (3/3) Alpha/beta hydrolase family
PF12544 (3/3) Lysine-2,3-aminomutase
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF00144 (3/3) Beta-lactamase
jaccard_groups_6089 138.26 +- 36.92 2 0 0 0 0.07 +- 0.14 2 15

TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF05141 (2/2) Pyoverdine/dityrosine biosynthesis protein
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00483 (2/2) Nucleotidyl transferase
PF00067 (2/2) Cytochrome P450
PF12833 (1/2) Helix-turn-helix domain
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF01965 (1/2) DJ-1/PfpI family
jaccard_groups_638 63.67 +- 85.97 17 0 8 0 0.17 +- 0.27 17 6

PF02805 (17/17) Metal binding domain of Ada
PF12833 (16/17) Helix-turn-helix domain
PF06029 (15/17) AlkA N-terminal domain
PF01035 (12/17) 6-O-methylguanine DNA methyltransferase, DNA binding domain
TIGR00589 (11/17) methylated-DNA--[protein]-cysteine S-methyltransferase
PF09859 (9/17) Oxygenase, catalysing oxidative methylation of damaged DNA
jaccard_groups_4878 928.32 +- 601.42 3 0 2 0 0.04 +- 0.17 3 10

TIGR01879 (3/3) amidase, hydantoinase/carbamoylase family
TIGR01037 (3/3) dihydroorotate dehydrogenase family protein
TIGR00857 (3/3) dihydroorotase, multifunctional complex type
PF10418 (3/3) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF09084 (3/3) NMT1/THI5 like
PF01979 (3/3) Amidohydrolase family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01180 (3/3) Dihydroorotate dehydrogenase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
jaccard_groups_4873 317.48 +- 134.02 2 0 2 0 0.03 +- 0.10 2 14

PF13578 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08031 (2/2) Berberine and berberine like
PF07366 (2/2) SnoaL-like polyketide cyclase
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF13459 (1/2) 4Fe-4S single cluster domain
PF08223 (1/2) PaaX-like protein C-terminal domain
PF07848 (1/2) PaaX-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF07681 (1/2) DoxX
PF01951 (1/2) Archease protein family (MTH1598/TM1083)
PF00067 (1/2) Cytochrome P450
jaccard_groups_3358 245.38 +- 147.97 7 0 0 0 0.02 +- 0.01 7 4

PF03737 (7/7) Aldolase/RraA
PF00994 (7/7) Probable molybdopterin binding domain
PF00682 (7/7) HMGL-like
PF00180 (7/7) Isocitrate/isopropylmalate dehydrogenase
jaccard_groups_3351 66.52 +- 42.91 3 0 0 0 0.09 +- 0.13 3 8

PF17765 (3/3) MmyB-like transcription regulator ligand binding domain
PF13602 (3/3) Zinc-binding dehydrogenase
PF13560 (3/3) Helix-turn-helix domain
PF12680 (3/3) SnoaL-like domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03358 (3/3) NADPH-dependent FMN reductase
PF01965 (2/3) DJ-1/PfpI family
PF01738 (2/3) Dienelactone hydrolase family
jaccard_groups_3353 127.63 +- 92.32 6 0 0 0 0.07 +- 0.16 6 9

PF13378 (6/6) Enolase C-terminal domain-like
PF08125 (6/6) Mannitol dehydrogenase C-terminal domain
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01232 (6/6) Mannitol dehydrogenase Rossmann domain
PF07690 (5/6) Major Facilitator Superfamily
PF13377 (3/6) Periplasmic binding protein-like domain
PF08240 (3/6) Alcohol dehydrogenase GroES-like domain
PF02826 (3/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00107 (3/6) Zinc-binding dehydrogenase
jaccard_groups_3355 91.71 +- 63.81 6 0 0 0 0.06 +- 0.04 6 5

PF00848 (6/6) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (6/6) Rieske [2Fe-2S] domain
PF00111 (6/6) 2Fe-2S iron-sulfur cluster binding domain
PF16884 (5/6) N-terminal domain of oxidoreductase
PF00107 (5/6) Zinc-binding dehydrogenase
jaccard_groups_3227 647.50 +- 2.50 6 0 6 0 0.01 +- 0.00 6 11

PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02812 (6/6) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00856 (6/6) SET domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00208 (6/6) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_3228 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
jaccard_groups_6311 1254.19 +- 981.81 2 0 0 0 0.09 +- 0.24 2 18

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01048 (2/2) diaminopimelate decarboxylase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13529 (2/2) Peptidase_C39 like family
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04951 (2/2) D-aminopeptidase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (2/2) Prolyl oligopeptidase family
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00005 (2/2) ABC transporter
PF14019 (1/2) Protein of unknown function (DUF4235)
PF12277 (1/2) Protein of unknown function (DUF3618)
PF07332 (1/2) Putative Actinobacterial Holin-X, holin superfamily III
jaccard_groups_278 61.37 +- 73.38 7 0 0 0 0.10 +- 0.17 7 2

PF03965 (7/7) Penicillinase repressor
PF01435 (7/7) Peptidase family M48
jaccard_groups_273 48.61 +- 60.54 26 0 0 0 0.12 +- 0.19 26 4

PF00970 (26/26) Oxidoreductase FAD-binding domain
PF00175 (26/26) Oxidoreductase NAD-binding domain
PF00042 (23/26) Globin
PF01243 (19/26) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_2612 54.72 +- 56.67 12 0 0 0 0.10 +- 0.13 12 6

PF13828 (12/12) Domain of unknown function (DUF4190)
PF09995 (12/12) Uncharacterized protein conserved in bacteria (DUF2236)
PF01738 (12/12) Dienelactone hydrolase family
TIGR00879 (11/12) MFS transporter, sugar porter (SP) family
PF05721 (11/12) Phytanoyl-CoA dioxygenase (PhyH)
PF00083 (11/12) Sugar (and other) transporter
jaccard_groups_270 72.00 +- 33.11 7 0 1 1 0.18 +- 0.32 7 15

TIGR01497 (7/7) K+-transporting ATPase, B subunit
TIGR00680 (7/7) K+-transporting ATPase, A subunit
PF09604 (7/7) F subunit of K+-transporting ATPase (Potass_KdpF)
PF03814 (7/7) Potassium-transporting ATPase A subunit
PF02669 (7/7) K+-transporting ATPase, c chain
PF00702 (7/7) haloacid dehalogenase-like hydrolase
PF00122 (7/7) E1-E2 ATPase
TIGR02115 (6/7) K+-transporting ATPase, F subunit
TIGR00681 (6/7) K+-transporting ATPase, C subunit
PF02702 (6/7) Osmosensitive K+ channel His kinase sensor domain
PF00582 (6/7) Universal stress protein family
TIGR01525 (5/7) heavy metal translocating P-type ATPase
TIGR00374 (5/7) TIGR00374 family protein
PF03706 (5/7) Lysylphosphatidylglycerol synthase TM region
PF01814 (5/7) Hemerythrin HHE cation binding domain
jaccard_groups_274 96.88 +- 88.70 7 0 1 0 0.06 +- 0.08 7 2

PF03713 (7/7) Domain of unknown function (DUF305)
PF13714 (4/7) Phosphoenolpyruvate phosphomutase
jaccard_groups_2880 167.62 +- 107.23 7 0 0 0 0.04 +- 0.12 7 5

PF09587 (7/7) Bacterial capsule synthesis protein PGA_cap
PF08386 (7/7) TAP-like protein
PF00561 (7/7) alpha/beta hydrolase fold
PF00348 (7/7) Polyprenyl synthetase
PF00144 (7/7) Beta-lactamase
jaccard_groups_2889 31.41 +- 15.98 3 0 0 0 0.10 +- 0.10 3 3

PF13692 (3/3) Glycosyl transferases group 1
PF06925 (3/3) Monogalactosyldiacylglycerol (MGDG) synthase
PF01522 (3/3) Polysaccharide deacetylase
jaccard_groups_2267 62.58 +- 48.11 16 0 16 1 0.08 +- 0.03 16 8

TIGR03150 (16/16) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR01230 (16/16) agmatinase
PF13561 (16/16) Enoyl-(Acyl carrier protein) reductase
PF02801 (16/16) Beta-ketoacyl synthase, C-terminal domain
PF00501 (16/16) AMP-binding enzyme
PF00491 (16/16) Arginase family
PF00109 (16/16) Beta-ketoacyl synthase, N-terminal domain
PF00069 (16/16) Protein kinase domain
jaccard_groups_3178 2585.94 +- 2489.11 8 0 0 0 0.01 +- 0.02 8 14

PF09084 (8/8) NMT1/THI5 like
PF07729 (8/8) FCD domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00528 (7/8) Binding-protein-dependent transport system inner membrane component
PF00005 (7/8) ABC transporter
PF12006 (6/8) Protein of unknown function (DUF3500)
PF06240 (6/8) Carbon monoxide dehydrogenase subunit G (CoxG)
PF04909 (6/8) Amidohydrolase
PF03328 (6/8) HpcH/HpaI aldolase/citrate lyase family
PF02776 (6/8) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/8) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (6/8) Thiamine pyrophosphate enzyme, central domain
PF00135 (6/8) Carboxylesterase family
PF10282 (5/8) Lactonase, 7-bladed beta-propeller
jaccard_groups_3179 34.14 +- 8.86 7 0 0 0 0.14 +- 0.23 7 8

PF14200 (7/7) Ricin-type beta-trefoil lectin domain-like
PF03777 (7/7) ChpA-C
PF01494 (7/7) FAD binding domain
PF00459 (7/7) Inositol monophosphatase family
PF00754 (6/7) F5/8 type C domain
PF09130 (5/7) Domain of unknown function (DUF1932)
PF00106 (5/7) short chain dehydrogenase
PF03446 (4/7) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_2173 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
jaccard_groups_3175 108.73 +- 58.41 2 0 1 0 0.03 +- 0.06 2 6

PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01183 (2/2) Glycosyl hydrolases family 25
PF13560 (1/2) Helix-turn-helix domain
PF13279 (1/2) Thioesterase-like superfamily
PF04149 (1/2) Domain of unknown function (DUF397)
PF01047 (1/2) MarR family
jaccard_groups_2170 436.54 +- 154.03 4 0 0 0 0.01 +- 0.01 4 5

PF01613 (4/4) Flavin reductase like domain
PF00296 (4/4) Luciferase-like monooxygenase
TIGR03571 (2/4) luciferase-type oxidoreductase, BA3436 family
PF00501 (2/4) AMP-binding enzyme
PF00378 (2/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_2177 91.27 +- 22.73 18 0 0 0 0.07 +- 0.04 18 10

TIGR03570 (18/18) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
PF17836 (18/18) PglD N-terminal domain
PF13313 (18/18) Domain of unknown function (DUF4082)
PF13205 (18/18) Bacterial Ig-like domain
PF01408 (18/18) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (18/18) NAD dependent epimerase/dehydratase family
PF01041 (18/18) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (17/18) Glycosyl transferase family 2
TIGR03025 (16/18) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF02397 (16/18) Bacterial sugar transferase
jaccard_groups_2176 167.78 +- 51.61 6 0 3 0 0.09 +- 0.21 6 19

PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00561 (6/6) alpha/beta hydrolase fold
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (6/6) Aminotransferase class-III
PF00171 (6/6) Aldehyde dehydrogenase family
PF00107 (6/6) Zinc-binding dehydrogenase
PF13581 (5/6) Histidine kinase-like ATPase domain
PF13561 (5/6) Enoyl-(Acyl carrier protein) reductase
PF07228 (5/6) Stage II sporulation protein E (SpoIIE)
PF00474 (5/6) Sodium:solute symporter family
PF13450 (4/6) NAD(P)-binding Rossmann-like domain
PF01590 (4/6) GAF domain
PF01593 (3/6) Flavin containing amine oxidoreductase
jaccard_groups_2175 465.34 +- 271.40 17 0 4 0 0.04 +- 0.05 17 8

PF09339 (17/17) IclR helix-turn-helix domain
PF05199 (17/17) GMC oxidoreductase
PF01261 (17/17) Xylose isomerase-like TIM barrel
PF00732 (17/17) GMC oxidoreductase
PF00528 (17/17) Binding-protein-dependent transport system inner membrane component
PF00480 (17/17) ROK family
PF00383 (17/17) Cytidine and deoxycytidylate deaminase zinc-binding region
PF13416 (16/17) Bacterial extracellular solute-binding protein
jaccard_groups_6252 390.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03589 (2/2) UDP-N-acetylglucosamine 4,6-dehydratase (inverting)
TIGR02246 (2/2) conserved hypothetical protein
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF02719 (2/2) Polysaccharide biosynthesis protein
PF01425 (2/2) Amidase
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_6257 410.42 +- 115.12 2 0 0 0 0.03 +- 0.04 2 16

TIGR00872 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14433 (2/2) SUKH-3 immunity protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13401 (2/2) AAA domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF06527 (2/2) TniQ
PF06414 (2/2) Zeta toxin
PF04199 (2/2) Putative cyclase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00665 (2/2) Integrase core domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_3598 2728.16 +- 778.76 5 0 5 0 0.01 +- 0.01 5 16

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
PF13649 (5/5) Methyltransferase domain
PF13560 (5/5) Helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07993 (5/5) Male sterility protein
PF00977 (5/5) Histidine biosynthesis protein
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00107 (5/5) Zinc-binding dehydrogenase
PF13304 (4/5) AAA domain, putative AbiEii toxin, Type IV TA system
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00005 (4/5) ABC transporter
jaccard_groups_3597 67.03 +- 59.88 6 0 2 0 0.10 +- 0.08 6 5

PF13673 (6/6) Acetyltransferase (GNAT) domain
PF13411 (6/6) MerR HTH family regulatory protein
PF08534 (6/6) Redoxin
PF05988 (3/6) Bacterial protein of unknown function (DUF899)
PF00701 (3/6) Dihydrodipicolinate synthetase family
jaccard_groups_6259 128.17 +- 24.49 2 0 2 2 0.13 +- 0.29 2 19

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13424 (2/2) Tetratricopeptide repeat
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08007 (2/2) Cupin superfamily protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00931 (2/2) NB-ARC domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
jaccard_groups_3592 405.84 +- 161.12 6 0 1 6 0.01 +- 0.03 6 7

TIGR00702 (6/6) YcaO-type kinase domain
PF13489 (6/6) Methyltransferase domain
PF07812 (6/6) TfuA-like protein
PF07690 (6/6) Major Facilitator Superfamily
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF18029 (5/6) Glyoxalase-like domain
PF13231 (5/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
jaccard_groups_3031 18.33 +- 4.51 2 0 2 0 0.19 +- 0.29 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03176 (2/2) MMPL family
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13426 (1/2) PAS domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01590 (1/2) GAF domain
PF00989 (1/2) PAS fold
jaccard_groups_668 30.59 +- 11.98 14 0 14 0 0.19 +- 0.26 14 7

PF04140 (14/14) Isoprenylcysteine carboxyl methyltransferase (ICMT) family
PF02797 (14/14) Chalcone and stilbene synthases, C-terminal domain
PF01494 (14/14) FAD binding domain
PF00195 (14/14) Chalcone and stilbene synthases, N-terminal domain
PF07690 (11/14) Major Facilitator Superfamily
PF00903 (8/14) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00313 (7/14) 'Cold-shock' DNA-binding domain
jaccard_groups_3573 204.91 +- 205.17 4 0 1 0 0.09 +- 0.22 4 9

PF13977 (4/4) BetI-type transcriptional repressor, C-terminal
PF04978 (4/4) Protein of unknown function (DUF664)
PF03372 (4/4) Endonuclease/Exonuclease/phosphatase family
PF13302 (3/4) Acetyltransferase (GNAT) domain
PF12697 (3/4) Alpha/beta hydrolase family
PF07366 (3/4) SnoaL-like polyketide cyclase
PF00486 (3/4) Transcriptional regulatory protein, C terminal
PF00072 (3/4) Response regulator receiver domain
PF00005 (3/4) ABC transporter
jaccard_groups_3576 23.06 +- 3.81 2 0 0 0 0.18 +- 0.30 2 15

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF18158 (1/2) Adaptive response protein AidB N-terminal domain
PF08281 (1/2) Sigma-70, region 4
PF07690 (1/2) Major Facilitator Superfamily
PF04542 (1/2) Sigma-70 region 2
PF03466 (1/2) LysR substrate binding domain
PF02803 (1/2) Thiolase, C-terminal domain
PF02515 (1/2) CoA-transferase family III
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00108 (1/2) Thiolase, N-terminal domain
PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_2864 95.13 +- 20.44 10 0 9 0 0.13 +- 0.10 10 11

TIGR03860 (10/10) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR00738 (10/10) Rrf2 family protein
PF13743 (10/10) Thioredoxin
PF08352 (10/10) Oligopeptide/dipeptide transporter, C-terminal region
PF02082 (10/10) Transcriptional regulator
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00496 (10/10) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (10/10) Luciferase-like monooxygenase
PF00005 (10/10) ABC transporter
TIGR03567 (9/10) FMN reductase
PF03358 (9/10) NADPH-dependent FMN reductase
jaccard_groups_2087 66.77 +- 27.77 2 0 1 0 0.03 +- 0.03 2 7

TIGR04362 (2/2) choice-of-anchor C domain
PF04862 (2/2) Protein of unknown function (DUF642)
PF00106 (2/2) short chain dehydrogenase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF02018 (1/2) Carbohydrate binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00704 (1/2) Glycosyl hydrolases family 18
jaccard_groups_3579 126.88 +- 123.19 3 0 0 0 0.15 +- 0.28 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF07729 (3/3) FCD domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF02777 (2/3) Iron/manganese superoxide dismutases, C-terminal domain
PF01839 (2/3) FG-GAP repeat
PF01636 (2/3) Phosphotransferase enzyme family
PF00081 (2/3) Iron/manganese superoxide dismutases, alpha-hairpin domain
jaccard_groups_662 107.18 +- 215.76 13 0 13 0 0.14 +- 0.21 13 7

PF02797 (12/13) Chalcone and stilbene synthases, C-terminal domain
PF00195 (12/13) Chalcone and stilbene synthases, N-terminal domain
PF13560 (10/13) Helix-turn-helix domain
PF17765 (9/13) MmyB-like transcription regulator ligand binding domain
PF00067 (8/13) Cytochrome P450
PF13561 (7/13) Enoyl-(Acyl carrier protein) reductase
PF01243 (7/13) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_663 69.94 +- 54.90 19 0 3 0 0.05 +- 0.03 19 3

PF02386 (19/19) Cation transport protein
PF02254 (18/19) TrkA-N domain
PF02080 (18/19) TrkA-C domain
jaccard_groups_2083 80.96 +- 42.88 4 0 3 0 0.06 +- 0.05 4 9

TIGR01686 (4/4) FkbH domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF01596 (3/4) O-methyltransferase
PF00725 (3/4) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00975 (2/4) Thioesterase domain
jaccard_groups_665 77.14 +- 29.59 5 0 0 0 0.03 +- 0.03 5 3

PF02566 (5/5) OsmC-like protein
TIGR03561 (4/5) peroxiredoxin, Ohr subfamily
PF00903 (4/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_666 23.34 +- 12.13 7 0 0 0 0.21 +- 0.37 7 9

TIGR03705 (7/7) polyphosphate kinase 1
PF17941 (7/7) Polyphosphate kinase C-terminal domain 1
PF13090 (7/7) Polyphosphate kinase C-terminal domain 2
PF13089 (7/7) Polyphosphate kinase N-terminal domain
PF05235 (7/7) CHAD domain
PF02503 (7/7) Polyphosphate kinase middle domain
PF00293 (7/7) NUDIX domain
PF00005 (5/7) ABC transporter
PF00392 (4/7) Bacterial regulatory proteins, gntR family
jaccard_groups_3777 1034.67 +- 3.77 3 0 0 0 0.01 +- 0.00 3 5

PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07690 (3/3) Major Facilitator Superfamily
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_3774 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_2721 35.11 +- 15.58 10 0 2 0 0.13 +- 0.14 10 7

PF13439 (10/10) Glycosyltransferase Family 4
PF00534 (10/10) Glycosyl transferases group 1
PF18011 (9/10) C-terminal domain found in long catalases
PF13520 (9/10) Amino acid permease
PF06628 (9/10) Catalase-related immune-responsive
PF02709 (9/10) N-terminal domain of galactosyltransferase
PF00199 (9/10) Catalase
jaccard_groups_2316 38.92 +- 24.12 6 0 0 0 0.20 +- 0.19 6 9

TIGR00505 (6/6) GTP cyclohydrolase II
PF03706 (6/6) Lysylphosphatidylglycerol synthase TM region
PF01242 (6/6) 6-pyruvoyl tetrahydropterin synthase
PF00925 (6/6) GTP cyclohydrolase II
PF00534 (6/6) Glycosyl transferases group 1
PF16653 (4/6) Saccharopine dehydrogenase C-terminal domain
PF05222 (4/6) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (4/6) Saccharopine dehydrogenase NADP binding domain
PF01266 (4/6) FAD dependent oxidoreductase
jaccard_groups_6320 245.55 +- 107.80 2 0 0 0 0.04 +- 0.08 2 8

PF06722 (2/2) Protein of unknown function (DUF1205)
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01804 (2/2) Penicillin amidase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
jaccard_groups_6326 557.62 +- 216.38 2 0 0 0 0.01 +- 0.02 2 12

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF07690 (2/2) Major Facilitator Superfamily
PF03951 (2/2) Glutamine synthetase, beta-Grasp domain
PF03738 (2/2) Glutathionylspermidine synthase preATP-grasp
PF01266 (2/2) FAD dependent oxidoreductase
PF00578 (2/2) AhpC/TSA family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF02655 (1/2) ATP-grasp domain
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_2312 284.79 +- 311.72 13 0 1 0 0.09 +- 0.16 13 11

PF00528 (13/13) Binding-protein-dependent transport system inner membrane component
PF00005 (13/13) ABC transporter
TIGR01726 (12/13) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (12/13) hydrolase CocE/NonD family protein
PF08530 (12/13) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (12/13) X-Pro dipeptidyl-peptidase (S15 family)
PF00583 (12/13) Acetyltransferase (GNAT) family
PF00497 (12/13) Bacterial extracellular solute-binding proteins, family 3
PF01244 (11/13) Membrane dipeptidase (Peptidase family M19)
PF07690 (7/13) Major Facilitator Superfamily
PF00296 (7/13) Luciferase-like monooxygenase
jaccard_groups_2955 2014.89 +- 824.36 9 0 1 0 0.01 +- 0.01 9 12

PF13560 (9/9) Helix-turn-helix domain
PF13393 (9/9) Histidyl-tRNA synthetase
PF03721 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01370 (9/9) NAD dependent epimerase/dehydratase family
PF01061 (9/9) ABC-2 type transporter
PF00984 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00005 (9/9) ABC transporter
PF17874 (8/9) MalT-like TPR region
PF05193 (8/9) Peptidase M16 inactive domain
PF00675 (8/9) Insulinase (Peptidase family M16)
jaccard_groups_2954 97.26 +- 83.02 8 0 0 0 0.12 +- 0.27 8 6

TIGR03086 (8/8) TIGR03086 family protein
PF14534 (8/8) Domain of unknown function (DUF4440)
PF11716 (8/8) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08002 (8/8) Protein of unknown function (DUF1697)
PF02983 (8/8) Alpha-lytic protease prodomain
PF00089 (8/8) Trypsin
jaccard_groups_2951 28.33 +- 0.72 3 0 2 0 0.21 +- 0.16 3 8

PF13439 (3/3) Glycosyltransferase Family 4
PF11847 (3/3) Alpha-(1->3)-arabinofuranosyltransferase
PF11271 (3/3) Porin PorA
PF08241 (3/3) Methyltransferase domain
PF03966 (3/3) Trm112p-like protein
PF00534 (3/3) Glycosyl transferases group 1
TIGR01444 (2/3) methyltransferase, FkbM family
PF05050 (2/3) Methyltransferase FkbM domain
jaccard_groups_6433 18.29 +- 3.21 2 0 0 0 0.17 +- 0.18 2 10

TIGR01068 (2/2) thioredoxin
PF17755 (2/2) UvrA DNA-binding domain
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (2/2) DDE superfamily endonuclease
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02148 (2/2) Zn-finger in ubiquitin-hydrolases and other protein
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_6430 184.36 +- 28.36 2 0 0 0 0.02 +- 0.01 2 5

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF00753 (2/2) Metallo-beta-lactamase superfamily
jaccard_groups_4857 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family
jaccard_groups_2772 418.00 +- 114.09 3 0 0 0 0.01 +- 0.00 3 5

PF13814 (3/3) Replication-relaxation
PF07508 (3/3) Recombinase
PF05063 (3/3) MT-A70
PF02534 (3/3) Type IV secretory system Conjugative DNA transfer
PF00239 (3/3) Resolvase, N terminal domain
jaccard_groups_2959 65.67 +- 20.41 7 0 7 0 0.06 +- 0.05 7 10

PF13454 (7/7) FAD-NAD(P)-binding
PF02896 (7/7) PEP-utilising enzyme, TIM barrel domain
PF02627 (7/7) Carboxymuconolactone decarboxylase family
PF00391 (7/7) PEP-utilising enzyme, mobile domain
TIGR01613 (6/7) phage/plasmid primase, P4 family, C-terminal domain
TIGR00778 (6/7) alkylhydroperoxidase AhpD family core domain
PF08706 (6/7) D5 N terminal like
PF09250 (5/7) Bifunctional DNA primase/polymerase, N-terminal
PF03288 (5/7) Poxvirus D5 protein-like
PF01717 (5/7) Cobalamin-independent synthase, Catalytic domain
jaccard_groups_2774 858.02 +- 420.18 9 0 2 0 0.02 +- 0.01 9 10

TIGR00710 (9/9) drug resistance transporter, Bcr/CflA subfamily
PF07690 (9/9) Major Facilitator Superfamily
PF03737 (9/9) Aldolase/RraA
PF03466 (9/9) LysR substrate binding domain
PF01361 (9/9) Tautomerase enzyme
PF00994 (9/9) Probable molybdopterin binding domain
PF00682 (9/9) HMGL-like
PF00180 (9/9) Isocitrate/isopropylmalate dehydrogenase
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
PF00890 (5/9) FAD binding domain
jaccard_groups_6438 586.95 +- 251.55 2 0 0 0 0.03 +- 0.01 2 12

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16889 (2/2) Heparinase II/III N-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08787 (2/2) Alginate lyase
PF07940 (2/2) Heparinase II/III-like protein
PF07602 (2/2) Protein of unknown function (DUF1565)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF13229 (1/2) Right handed beta helix region
jaccard_groups_469 86.87 +- 86.69 11 0 1 0 0.05 +- 0.06 11 1

PF01810 (11/11) LysE type translocator
jaccard_groups_463 67.87 +- 28.77 5 0 2 0 0.08 +- 0.17 5 6

PF13361 (4/5) UvrD-like helicase C-terminal domain
PF13245 (3/5) AAA domain
PF09369 (3/5) Domain of unknown function (DUF1998)
PF04851 (3/5) Type III restriction enzyme, res subunit
PF00271 (3/5) Helicase conserved C-terminal domain
PF00069 (3/5) Protein kinase domain
jaccard_groups_467 176.56 +- 78.20 10 0 7 0 0.03 +- 0.08 10 3

TIGR02050 (10/10) carboxylate-amine ligase, YbdK family
PF04107 (10/10) Glutamate-cysteine ligase family 2(GCS2)
PF09860 (7/10) Uncharacterized protein conserved in bacteria (DUF2087)
jaccard_groups_2794 42.58 +- 20.45 4 0 4 0 0.07 +- 0.08 4 2

PF11991 (4/4) Tryptophan dimethylallyltransferase
PF01212 (4/4) Beta-eliminating lyase
jaccard_groups_2798 45.03 +- 12.22 2 0 0 0 0.10 +- 0.07 2 11

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13361 (2/2) UvrD-like helicase C-terminal domain
PF13245 (2/2) AAA domain
PF12833 (2/2) Helix-turn-helix domain
PF05593 (2/2) RHS Repeat
PF04264 (2/2) YceI-like domain
PF03527 (2/2) RHS protein
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00069 (2/2) Protein kinase domain
jaccard_groups_2551 13.82 +- 4.87 2 0 0 0 0.22 +- 0.37 2 5

TIGR00544 (2/2) prolipoprotein diacylglyceryl transferase
PF03965 (2/2) Penicillinase repressor
PF01790 (2/2) Prolipoprotein diacylglyceryl transferase
PF01435 (2/2) Peptidase family M48
PF12802 (1/2) MarR family
jaccard_groups_5209 1195.93 +- 392.03 3 0 1 0 0.01 +- 0.01 3 9

PF13483 (3/3) Beta-lactamase superfamily domain
PF09084 (3/3) NMT1/THI5 like
PF03972 (3/3) MmgE/PrpD family
PF03466 (3/3) LysR substrate binding domain
PF03328 (3/3) HpcH/HpaI aldolase/citrate lyase family
PF01361 (3/3) Tautomerase enzyme
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (3/3) ABC transporter
jaccard_groups_2553 647.25 +- 555.91 9 0 0 0 0.04 +- 0.08 9 9

TIGR00711 (9/9) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (9/9) Tetracyclin repressor-like, C-terminal domain
PF14224 (9/9) Domain of unknown function (DUF4331)
PF08240 (9/9) Alcohol dehydrogenase GroES-like domain
PF07690 (9/9) Major Facilitator Superfamily
PF00925 (9/9) GTP cyclohydrolase II
PF00440 (9/9) Bacterial regulatory proteins, tetR family
PF00107 (9/9) Zinc-binding dehydrogenase
PF04686 (5/9) Streptomyces sporulation and cell division protein, SsgA
jaccard_groups_2227 115.46 +- 112.78 8 0 0 0 0.08 +- 0.13 8 6

PF11303 (8/8) Protein of unknown function (DUF3105)
PF03713 (8/8) Domain of unknown function (DUF305)
PF09286 (7/8) Pro-kumamolisin, activation domain
PF00082 (7/8) Subtilase family
PF02540 (4/8) NAD synthase
PF00795 (4/8) Carbon-nitrogen hydrolase
jaccard_groups_2226 11.39 +- 4.37 3 0 1 0 0.21 +- 0.18 3 4

TIGR01392 (3/3) homoserine O-acetyltransferase
TIGR01326 (3/3) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_2225 55.60 +- 32.89 3 0 1 0 0.09 +- 0.12 3 3

PF08241 (3/3) Methyltransferase domain
PF13649 (2/3) Methyltransferase domain
PF00293 (2/3) NUDIX domain
jaccard_groups_2224 193.50 +- 64.50 2 0 2 0 0.01 +- 0.01 2 2

PF07993 (2/2) Male sterility protein
PF00202 (2/2) Aminotransferase class-III
jaccard_groups_5202 207.00 +- 16.07 3 0 0 0 0.05 +- 0.07 3 16

PF11308 (3/3) Glycosyl hydrolases related to GH101 family, GH129
PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF04185 (3/3) Phosphoesterase family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00171 (3/3) Aldehyde dehydrogenase family
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450
jaccard_groups_2228 513.39 +- 333.68 17 0 0 0 0.02 +- 0.01 17 8

PF07859 (17/17) alpha/beta hydrolase fold
PF07690 (17/17) Major Facilitator Superfamily
PF03959 (17/17) Serine hydrolase (FSH1)
PF01590 (17/17) GAF domain
PF00756 (17/17) Putative esterase
PF00561 (17/17) alpha/beta hydrolase fold
PF00196 (17/17) Bacterial regulatory proteins, luxR family
PF00144 (17/17) Beta-lactamase
jaccard_groups_5514 314.74 +- 75.26 2 0 0 0 0.01 +- 0.02 2 8

PF17645 (2/2) Arylmalonate decarboxylase
PF07729 (2/2) FCD domain
PF01494 (2/2) FAD binding domain
PF00857 (2/2) Isochorismatase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_5685 388.50 +- 1.50 2 0 0 0 0.01 +- 0.00 2 9

TIGR01205 (2/2) D-alanine--D-alanine ligase
TIGR00492 (2/2) alanine racemase
PF13560 (2/2) Helix-turn-helix domain
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF04149 (2/2) Domain of unknown function (DUF397)
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00842 (2/2) Alanine racemase, C-terminal domain
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
jaccard_groups_5683 711.18 +- 425.39 2 0 2 0 0.04 +- 0.09 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12261 (2/2) Thermostable hemolysin
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07977 (2/2) FabA-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF01593 (1/2) Flavin containing amine oxidoreductase
jaccard_groups_2424 589.96 +- 204.91 9 0 8 0 0.02 +- 0.03 9 16

TIGR01835 (9/9) hydroxymethylglutaryl-CoA synthase
TIGR01240 (9/9) diphosphomevalonate decarboxylase
TIGR01220 (9/9) phosphomevalonate kinase
TIGR00549 (9/9) mevalonate kinase
PF18376 (9/9) Mevalonate 5-diphosphate decarboxylase C-terminal domain
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08544 (9/9) GHMP kinases C terminal
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08540 (9/9) Hydroxymethylglutaryl-coenzyme A synthase C terminal
PF01154 (9/9) Hydroxymethylglutaryl-coenzyme A synthase N terminal
PF00368 (9/9) Hydroxymethylglutaryl-coenzyme A reductase
PF00288 (9/9) GHMP kinases N terminal domain
TIGR02151 (8/9) isopentenyl-diphosphate delta-isomerase, type 2
PF01070 (8/9) FMN-dependent dehydrogenase
PF00348 (7/9) Polyprenyl synthetase
PF01593 (5/9) Flavin containing amine oxidoreductase
jaccard_groups_2421 583.00 +- 67.00 2 0 1 0 0.01 +- 0.00 2 8

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF12802 (1/2) MarR family
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF07859 (1/2) alpha/beta hydrolase fold
PF03358 (1/2) NADPH-dependent FMN reductase
PF01761 (1/2) 3-dehydroquinate synthase
jaccard_groups_2420 156.86 +- 101.14 2 0 1 0 0.02 +- 0.03 2 5

PF09129 (2/2) Cholesterol oxidase, substrate-binding
PF01565 (2/2) FAD binding domain
PF07995 (1/2) Glucose / Sorbosone dehydrogenase
PF06283 (1/2) Trehalose utilisation
PF00494 (1/2) Squalene/phytoene synthase
jaccard_groups_2422 72.38 +- 43.72 2 0 2 1 0.18 +- 0.18 2 21

TIGR02050 (2/2) carboxylate-amine ligase, YbdK family
TIGR01382 (2/2) intracellular protease, PfpI family
PF17196 (2/2) Protein of unknown function (DUF5133)
PF13828 (2/2) Domain of unknown function (DUF4190)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF08768 (2/2) Domain of unknown function (DUF1794)
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04954 (2/2) Siderophore-interacting protein
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF03621 (2/2) MbtH-like protein
PF01965 (2/2) DJ-1/PfpI family
PF01594 (2/2) AI-2E family transporter
PF00037 (2/2) 4Fe-4S binding domain
TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF13360 (1/2) PQQ-like domain
PF05406 (1/2) WGR domain
PF03707 (1/2) Bacterial signalling protein N terminal repeat
PF01341 (1/2) Glycosyl hydrolases family 6
PF00942 (1/2) Cellulose binding domain
PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_5336 1135.75 +- 684.25 2 0 2 0 0.01 +- 0.01 2 11

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF12697 (2/2) Alpha/beta hydrolase family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01761 (2/2) 3-dehydroquinate synthase
PF01757 (2/2) Acyltransferase family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
PF00480 (1/2) ROK family
jaccard_groups_2429 320.24 +- 324.37 3 0 1 0 0.10 +- 0.28 3 6

PF03704 (3/3) Bacterial transcriptional activator domain
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00486 (3/3) Transcriptional regulatory protein, C terminal
jaccard_groups_52 41.61 +- 52.66 24 0 8 0 0.13 +- 0.23 24 5

TIGR01525 (24/24) heavy metal translocating P-type ATPase
PF00702 (24/24) haloacid dehalogenase-like hydrolase
PF00122 (24/24) E1-E2 ATPase
PF00403 (22/24) Heavy-metal-associated domain
PF04314 (16/24) Copper chaperone PCu(A)C
jaccard_groups_5332 31.47 +- 5.98 2 0 0 0 0.08 +- 0.08 2 6

PF17269 (2/2) Family of unknown function (DUF5335)
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF00753 (2/2) Metallo-beta-lactamase superfamily
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_681 149.75 +- 80.50 15 0 2 0 0.03 +- 0.03 15 3

PF01120 (12/15) Alpha-L-fucosidase
PF00754 (11/15) F5/8 type C domain
PF14200 (9/15) Ricin-type beta-trefoil lectin domain-like
jaccard_groups_687 140.53 +- 189.83 5 0 2 0 0.08 +- 0.16 5 1

PF02525 (5/5) Flavodoxin-like fold
jaccard_groups_684 63.75 +- 9.72 2 0 0 0 0.21 +- 0.27 2 18

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF07690 (2/2) Major Facilitator Superfamily
PF04237 (2/2) YjbR
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF01381 (2/2) Helix-turn-helix
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00361 (2/2) Proton-conducting membrane transporter
TIGR01822 (1/2) glycine C-acetyltransferase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF03466 (1/2) LysR substrate binding domain
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_688 24.59 +- 12.14 18 0 9 0 0.14 +- 0.08 18 3

PF17851 (18/18) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (18/18) Glycosyl hydrolases family 43
PF00106 (9/18) short chain dehydrogenase
jaccard_groups_841 135.31 +- 124.69 2 0 2 2 0.08 +- 0.09 2 3

PF00881 (2/2) Nitroreductase family
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_844 112.33 +- 11.79 3 0 0 0 0.03 +- 0.02 3 3

PF04326 (3/3) Putative DNA-binding domain
PF08445 (2/3) FR47-like protein
PF03235 (2/3) Protein of unknown function DUF262
jaccard_groups_59 30.95 +- 6.19 2 0 0 0 0.07 +- 0.09 2 7

PF00144 (2/2) Beta-lactamase
PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF07045 (1/2) Domain of unknown function (DUF1330)
PF05141 (1/2) Pyoverdine/dityrosine biosynthesis protein
PF00082 (1/2) Subtilase family
PF00067 (1/2) Cytochrome P450
jaccard_groups_849 79.24 +- 70.05 10 0 0 0 0.07 +- 0.13 10 2

PF00775 (10/10) Dioxygenase
PF01874 (8/10) ATP:dephospho-CoA triphosphoribosyl transferase
jaccard_groups_5020 51.53 +- 29.25 2 0 0 0 0.12 +- 0.20 2 5

PF14435 (2/2) SUKH-4 immunity protein
PF07690 (2/2) Major Facilitator Superfamily
PF01872 (2/2) RibD C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01206 (2/2) Sulfurtransferase TusA
jaccard_groups_1216 247.90 +- 212.30 21 0 4 2 0.04 +- 0.08 21 4

PF04444 (21/21) Catechol dioxygenase N terminus
PF00775 (21/21) Dioxygenase
PF00465 (19/21) Iron-containing alcohol dehydrogenase
PF01494 (17/21) FAD binding domain
jaccard_groups_1214 68.79 +- 74.14 3 0 1 0 0.13 +- 0.26 3 4

PF09364 (3/3) XFP N-terminal domain
PF09363 (3/3) XFP C-terminal domain
PF03894 (3/3) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF00582 (2/3) Universal stress protein family
jaccard_groups_5025 637.66 +- 461.28 3 0 3 3 0.02 +- 0.02 3 15

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF17837 (3/3) 4'-phosphopantetheinyl transferase N-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12146 (3/3) Serine aminopeptidase, S33
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF05138 (3/3) Phenylacetic acid catabolic protein
PF04055 (3/3) Radical SAM superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_5029 320.43 +- 63.17 3 0 3 0 0.03 +- 0.06 3 14

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13183 (3/3) 4Fe-4S dicluster domain
PF10370 (3/3) Domain of unknown function (DUF2437)
PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01565 (3/3) FAD binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_1218 625.03 +- 994.07 9 0 0 0 0.03 +- 0.09 9 5

TIGR00212 (9/9) hydroxymethylbilane synthase
PF01379 (9/9) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (7/9) NUDIX domain
PF00005 (7/9) ABC transporter
PF03900 (6/9) Porphobilinogen deaminase, C-terminal domain
jaccard_groups_1862 81.77 +- 17.27 2 0 0 0 0.05 +- 0.04 2 8

TIGR00836 (2/2) ammonium transporter
TIGR00101 (2/2) urease accessory protein UreG
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01774 (2/2) UreD urease accessory protein
PF00909 (2/2) Ammonium Transporter Family
PF18029 (1/2) Glyoxalase-like domain
PF10094 (1/2) Uncharacterized protein conserved in bacteria (DUF2332)
PF01730 (1/2) UreF
jaccard_groups_1866 154.38 +- 105.62 2 0 0 0 0.03 +- 0.03 2 4

PF09992 (2/2) Phosphodiester glycosidase
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00355 (1/2) Rieske [2Fe-2S] domain
jaccard_groups_1859 147.34 +- 99.36 10 0 0 0 0.06 +- 0.05 10 9

PF14200 (10/10) Ricin-type beta-trefoil lectin domain-like
PF00652 (10/10) Ricin-type beta-trefoil lectin domain
PF17801 (8/10) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (8/10) Alpha galactosidase A
PF09206 (8/10) Alpha-L-arabinofuranosidase B, catalytic
PF01120 (8/10) Alpha-L-fucosidase
PF10503 (7/10) Esterase PHB depolymerase
PF02057 (7/10) Glycosyl hydrolase family 59
PF13472 (6/10) GDSL-like Lipase/Acylhydrolase family
jaccard_groups_1856 46.80 +- 21.82 8 0 0 0 0.16 +- 0.26 8 8

PF00440 (8/8) Bacterial regulatory proteins, tetR family
PF14472 (7/8) Domain of unknown function (DUF4429)
PF17754 (5/8) MftR C-terminal domain
PF07730 (5/8) Histidine kinase
PF06259 (5/8) Alpha/beta hydrolase
PF00196 (5/8) Bacterial regulatory proteins, luxR family
PF00072 (5/8) Response regulator receiver domain
PF09851 (4/8) Short C-terminal domain
jaccard_groups_1851 33.30 +- 43.03 5 0 1 0 0.14 +- 0.23 5 2

TIGR01048 (5/5) diaminopimelate decarboxylase
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
jaccard_groups_1852 14.74 +- 0.08 2 0 0 0 0.14 +- 0.13 2 5

PF12950 (2/2) TaqI-like C-terminal specificity domain
PF07669 (2/2) Eco57I restriction-modification methylase
PF04555 (2/2) Restriction endonuclease XhoI
PF02441 (2/2) Flavoprotein
PF00293 (2/2) NUDIX domain
jaccard_groups_1458 58.49 +- 3.20 2 0 0 0 0.11 +- 0.07 2 7

PF13411 (2/2) MerR HTH family regulatory protein
PF00248 (2/2) Aldo/keto reductase family
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF09278 (1/2) MerR, DNA binding
PF07730 (1/2) Histidine kinase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
jaccard_groups_1450 37.48 +- 20.19 34 0 0 0 0.11 +- 0.11 34 12

TIGR01524 (34/34) magnesium-translocating P-type ATPase
PF17668 (34/34) Acetyltransferase (GNAT) domain
PF13530 (34/34) Sterol carrier protein domain
PF13527 (34/34) Acetyltransferase (GNAT) domain
PF02308 (34/34) MgtC family
PF00702 (34/34) haloacid dehalogenase-like hydrolase
PF00690 (34/34) Cation transporter/ATPase, N-terminus
PF00689 (34/34) Cation transporting ATPase, C-terminus
PF00122 (34/34) E1-E2 ATPase
PF03466 (33/34) LysR substrate binding domain
PF01361 (33/34) Tautomerase enzyme
PF00126 (33/34) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1455 105.63 +- 50.21 9 0 9 0 0.03 +- 0.01 9 4

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
PF03756 (9/9) A-factor biosynthesis hotdog domain
PF00067 (9/9) Cytochrome P450
PF00702 (8/9) haloacid dehalogenase-like hydrolase
jaccard_groups_1325 68.79 +- 32.59 35 0 6 0 0.17 +- 0.14 35 6

PF00728 (35/35) Glycosyl hydrolase family 20, catalytic domain
PF00528 (34/35) Binding-protein-dependent transport system inner membrane component
PF00942 (33/35) Cellulose binding domain
PF01547 (32/35) Bacterial extracellular solute-binding protein
PF00722 (32/35) Glycosyl hydrolases family 16
PF02838 (31/35) Glycosyl hydrolase family 20, domain 2
jaccard_groups_1292 32.51 +- 43.48 29 0 8 0 0.19 +- 0.09 29 7

PF13377 (29/29) Periplasmic binding protein-like domain
PF05378 (29/29) Hydantoinase/oxoprolinase N-terminal region
PF01968 (29/29) Hydantoinase/oxoprolinase
PF00356 (29/29) Bacterial regulatory proteins, lacI family
PF12831 (28/29) FAD dependent oxidoreductase
PF06808 (28/29) Tripartite ATP-independent periplasmic transporter, DctM component
PF07859 (22/29) alpha/beta hydrolase fold
jaccard_groups_4469 1270.62 +- 117.44 3 0 3 0 0.01 +- 0.01 3 18

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07859 (3/3) alpha/beta hydrolase fold
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02780 (3/3) Transketolase, C-terminal domain
PF02779 (3/3) Transketolase, pyrimidine binding domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00676 (3/3) Dehydrogenase E1 component
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00155 (3/3) Aminotransferase class I and II
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_5663 316.26 +- 199.74 2 0 0 0 0.02 +- 0.03 2 13

PF17124 (2/2) ThiJ/PfpI family-like
PF13466 (2/2) STAS domain
PF07221 (2/2) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00483 (2/2) Nucleotidyl transferase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF13577 (1/2) SnoaL-like domain
PF02880 (1/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_4463 601.71 +- 122.57 2 0 0 2 0.01 +- 0.00 2 11

PF16864 (2/2) Dimerisation domain
PF13649 (2/2) Methyltransferase domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00891 (2/2) O-methyltransferase domain
PF00670 (2/2) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
jaccard_groups_4466 3540.14 +- 3032.69 3 0 1 3 0.01 +- 0.03 3 26

TIGR01762 (3/3) chlorinating enzyme
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14805 (3/3) Tetrahydrodipicolinate N-succinyltransferase N-terminal
PF14602 (3/3) Hexapeptide repeat of succinyl-transferase
PF13535 (3/3) ATP-grasp domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF05199 (3/3) GMC oxidoreductase
PF04909 (3/3) Amidohydrolase
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00733 (3/3) Asparagine synthase
PF00732 (3/3) GMC oxidoreductase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00278 (3/3) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00155 (3/3) Aminotransferase class I and II
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF18130 (2/3) ATP-grasp N-terminal domain
PF13537 (2/3) Glutamine amidotransferase domain
PF05960 (2/3) Bacterial protein of unknown function (DUF885)
jaccard_groups_1529 112.22 +- 101.08 4 0 0 0 0.11 +- 0.25 4 3

PF09335 (4/4) SNARE associated Golgi protein
PF07681 (4/4) DoxX
PF09423 (3/4) PhoD-like phosphatase
jaccard_groups_1036 16.02 +- 0.10 2 0 0 0 0.12 +- 0.08 2 4

TIGR01695 (2/2) murein biosynthesis integral membrane protein MurJ
PF03023 (2/2) Lipid II flippase MurJ
PF01810 (2/2) LysE type translocator
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_1527 223.33 +- 208.16 14 0 1 0 0.05 +- 0.10 14 3

PF07690 (14/14) Major Facilitator Superfamily
PF00293 (14/14) NUDIX domain
PF01227 (13/14) GTP cyclohydrolase I
jaccard_groups_1034 48.61 +- 23.14 6 0 0 0 0.17 +- 0.34 6 8

PF07690 (6/6) Major Facilitator Superfamily
PF05362 (6/6) Lon protease (S16) C-terminal proteolytic domain
TIGR03921 (4/6) type VII secretion-associated serine protease mycosin
TIGR01550 (4/6) death-on-curing family protein
PF09339 (4/6) IclR helix-turn-helix domain
PF02661 (4/6) Fic/DOC family
PF00082 (4/6) Subtilase family
PF04851 (3/6) Type III restriction enzyme, res subunit
jaccard_groups_1031 165.83 +- 94.17 2 0 1 0 0.04 +- 0.05 2 11

PF17203 (2/2) Single cache domain 3
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
TIGR01979 (1/2) cysteine desulfurase, SufS family
PF13641 (1/2) Glycosyltransferase like family 2
PF13188 (1/2) PAS domain
PF02254 (1/2) TrkA-N domain
PF01757 (1/2) Acyltransferase family
PF00266 (1/2) Aminotransferase class-V
PF00027 (1/2) Cyclic nucleotide-binding domain
jaccard_groups_4067 304.17 +- 54.17 2 0 0 0 0.03 +- 0.04 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
jaccard_groups_4066 90.33 +- 51.30 4 0 1 0 0.08 +- 0.10 4 5

PF01427 (4/4) D-ala-D-ala dipeptidase
PF00293 (4/4) NUDIX domain
PF00005 (4/4) ABC transporter
PF01425 (2/4) Amidase
PF00069 (2/4) Protein kinase domain
jaccard_groups_4068 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
jaccard_groups_3966 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
jaccard_groups_3963 52.42 +- 37.23 2 0 1 0 0.13 +- 0.28 2 10

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00553 (2/2) Cellulose binding domain
TIGR01341 (1/2) aconitate hydratase 1
PF13439 (1/2) Glycosyltransferase Family 4
PF00694 (1/2) Aconitase C-terminal domain
PF00672 (1/2) HAMP domain
PF00534 (1/2) Glycosyl transferases group 1
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00330 (1/2) Aconitase family (aconitate hydratase)
jaccard_groups_3960 420.50 +- 335.82 5 0 0 0 0.08 +- 0.18 5 14

TIGR01727 (5/5) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01428 (5/5) haloacid dehalogenase, type II
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF08352 (5/5) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (5/5) FCD domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00496 (5/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00005 (5/5) ABC transporter
TIGR01297 (4/5) cation diffusion facilitator family transporter
PF16916 (4/5) Dimerisation domain of Zinc Transporter
PF01545 (4/5) Cation efflux family
PF00171 (4/5) Aldehyde dehydrogenase family
jaccard_groups_3969 655.79 +- 464.04 5 0 5 5 0.04 +- 0.14 5 14

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00630 (5/5) excinuclease ABC subunit A
PF17755 (5/5) UvrA DNA-binding domain
PF07730 (5/5) Histidine kinase
PF07690 (5/5) Major Facilitator Superfamily
PF06722 (5/5) Protein of unknown function (DUF1205)
PF04101 (5/5) Glycosyltransferase family 28 C-terminal domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00881 (5/5) Nitroreductase family
PF00190 (5/5) Cupin
jaccard_groups_4207 1442.18 +- 592.37 4 0 3 2 0.02 +- 0.04 4 11

PF01663 (4/4) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01061 (4/4) ABC-2 type transporter
PF00550 (4/4) Phosphopantetheine attachment site
PF00005 (4/4) ABC transporter
TIGR01179 (3/4) UDP-glucose 4-epimerase GalE
PF02585 (3/4) GlcNAc-PI de-N-acetylase
PF01569 (3/4) PAP2 superfamily
PF01370 (3/4) NAD dependent epimerase/dehydratase family
PF00534 (3/4) Glycosyl transferases group 1
PF00300 (3/4) Histidine phosphatase superfamily (branch 1)
PF04055 (2/4) Radical SAM superfamily
jaccard_groups_4203 41.78 +- 18.92 2 0 0 0 0.12 +- 0.09 2 5

TIGR00504 (2/2) pyroglutamyl-peptidase I
PF11199 (2/2) Protein of unknown function (DUF2891)
PF06166 (2/2) Protein of unknown function (DUF979)
PF06149 (2/2) Protein of unknown function (DUF969)
PF01470 (2/2) Pyroglutamyl peptidase
jaccard_groups_4202 26.59 +- 10.34 2 0 0 0 0.23 +- 0.33 2 10

TIGR02094 (2/2) alpha-glucan phosphorylases
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF11897 (2/2) Protein of unknown function (DUF3417)
PF07730 (2/2) Histidine kinase
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00343 (2/2) Carbohydrate phosphorylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
jaccard_groups_4201 335.33 +- 121.62 4 0 1 0 0.04 +- 0.03 4 9

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (4/4) Periplasmic binding protein-like domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF12833 (3/4) Helix-turn-helix domain
PF01965 (3/4) DJ-1/PfpI family
jaccard_groups_1140 146.20 +- 194.66 27 0 7 21 0.13 +- 0.17 27 18

PF00403 (26/27) Heavy-metal-associated domain
TIGR01525 (25/27) heavy metal translocating P-type ATPase
PF04314 (25/27) Copper chaperone PCu(A)C
PF00702 (25/27) haloacid dehalogenase-like hydrolase
PF00122 (25/27) E1-E2 ATPase
TIGR02937 (24/27) RNA polymerase sigma factor, sigma-70 family
PF08281 (24/27) Sigma-70, region 4
PF04542 (24/27) Sigma-70 region 2
PF01497 (24/27) Periplasmic binding protein
PF01032 (24/27) FecCD transport family
PF00005 (24/27) ABC transporter
PF00733 (21/27) Asparagine synthase
TIGR01536 (20/27) asparagine synthase (glutamine-hydrolyzing)
PF13537 (20/27) Glutamine amidotransferase domain
PF00067 (20/27) Cytochrome P450
PF05141 (18/27) Pyoverdine/dityrosine biosynthesis protein
PF07690 (17/27) Major Facilitator Superfamily
PF06197 (14/27) Protein of unknown function (DUF998)
jaccard_groups_4666 921.11 +- 384.91 3 0 0 0 0.01 +- 0.00 3 9

PF14310 (3/3) Fibronectin type III-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00232 (3/3) Glycosyl hydrolase family 1
PF16353 (2/3) Domain of unknown function(DUF4981)
PF02929 (2/3) Beta galactosidase small chain
PF02837 (2/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/3) Glycosyl hydrolases family 2, TIM barrel domain
jaccard_groups_4680 165.86 +- 0.00 2 0 2 0 0.02 +- 0.02 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13601 (2/2) Winged helix DNA-binding domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03403 (2/2) Platelet-activating factor acetylhydrolase, isoform II
PF00501 (2/2) AMP-binding enzyme
jaccard_groups_4687 322.67 +- 93.33 2 0 0 0 0.01 +- 0.01 2 4

PF12006 (2/2) Protein of unknown function (DUF3500)
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_4686 605.60 +- 393.34 3 0 3 2 0.01 +- 0.01 3 11

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16861 (3/3) Carbamoyltransferase C-terminus
PF14518 (3/3) Iron-containing redox enzyme
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
TIGR04085 (2/3) radical SAM additional 4Fe4S-binding SPASM domain
PF05977 (2/3) Transmembrane secretion effector
PF04055 (2/3) Radical SAM superfamily
PF01048 (2/3) Phosphorylase superfamily
jaccard_groups_4685 1241.52 +- 1144.44 3 0 3 0 0.04 +- 0.10 3 20

TIGR01733 (3/3) amino acid adenylation domain
TIGR01444 (3/3) methyltransferase, FkbM family
PF17837 (3/3) 4'-phosphopantetheinyl transferase N-terminal domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF05050 (3/3) Methyltransferase FkbM domain
PF03621 (3/3) MbtH-like protein
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
PF05995 (2/3) Cysteine dioxygenase type I
jaccard_groups_4688 185.29 +- 74.71 2 0 2 0 0.01 +- 0.01 2 3

PF02195 (2/2) ParB-like nuclease domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
jaccard_groups_4841 1530.48 +- 523.91 3 0 2 0 0.01 +- 0.03 3 14

PF05193 (3/3) Peptidase M16 inactive domain
PF01937 (3/3) Protein of unknown function DUF89
PF01326 (3/3) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (3/3) ABC-2 type transporter
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00391 (3/3) PEP-utilising enzyme, mobile domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF03965 (2/3) Penicillinase repressor
PF01475 (2/3) Ferric uptake regulator family
PF01435 (2/3) Peptidase family M48
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_4512 58.18 +- 2.13 2 0 0 0 0.15 +- 0.08 2 8

PF07969 (2/2) Amidohydrolase family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF01047 (2/2) MarR family
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_4842 645.00 +- 0.00 3 0 3 0 0.01 +- 0.00 3 10

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF04101 (3/3) Glycosyltransferase family 28 C-terminal domain
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03023 (3/3) Lipid II flippase MurJ
PF02397 (3/3) Bacterial sugar transferase
PF01522 (3/3) Polysaccharide deacetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
jaccard_groups_4516 48.87 +- 0.00 2 0 0 0 0.20 +- 0.39 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (2/2) argininosuccinate lyase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07905 (2/2) Purine catabolism regulatory protein-like family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00491 (2/2) Arginase family
PF00206 (2/2) Lyase
PF00005 (2/2) ABC transporter
jaccard_groups_4846 451.12 +- 125.20 3 0 2 0 0.03 +- 0.03 3 10

PF14742 (3/3) N-terminal domain of (some) glycogen debranching enzymes
PF10282 (3/3) Lactonase, 7-bladed beta-propeller
PF07883 (3/3) Cupin domain
PF07729 (3/3) FCD domain
PF06202 (3/3) Amylo-alpha-1,6-glucosidase
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF03600 (3/3) Citrate transporter
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
jaccard_groups_4849 40.24 +- 11.36 2 0 0 0 0.06 +- 0.08 2 8

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF16656 (2/2) Purple acid Phosphatase, N-terminal domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07971 (2/2) Glycosyl hydrolase family 92
PF01638 (2/2) HxlR-like helix-turn-helix
PF00149 (2/2) Calcineurin-like phosphoesterase
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
jaccard_groups_4518 140.60 +- 64.81 3 0 0 0 0.03 +- 0.04 3 5

PF13564 (3/3) DoxX-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (3/3) NADPH-dependent FMN reductase
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_3211 213.71 +- 68.52 5 0 5 0 0.02 +- 0.01 5 4

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF04673 (5/5) Polyketide synthesis cyclase
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF00067 (5/5) Cytochrome P450
jaccard_groups_208 187.13 +- 232.87 31 0 0 31 0.08 +- 0.21 31 9

TIGR04269 (31/31) radical SAM/SPASM domain protein, FxsB family
PF13424 (31/31) Tetratricopeptide repeat
PF04055 (31/31) Radical SAM superfamily
PF13676 (30/31) TIR domain
TIGR04267 (27/31) HEXXH motif domain
PF13374 (27/31) Tetratricopeptide repeat
TIGR04276 (25/31) FxsC C-terminal domain
PF00931 (25/31) NB-ARC domain
PF01656 (16/31) CobQ/CobB/MinD/ParA nucleotide binding domain
jaccard_groups_3827 90.81 +- 45.38 5 0 0 0 0.14 +- 0.14 5 8

TIGR03696 (5/5) RHS repeat-associated core domain
TIGR01643 (5/5) YD repeat (two copies)
PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF05593 (5/5) RHS Repeat
PF03527 (5/5) RHS protein
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
jaccard_groups_207 115.95 +- 110.65 11 0 2 0 0.10 +- 0.26 11 1

PF01370 (11/11) NAD dependent epimerase/dehydratase family
jaccard_groups_2152 51.02 +- 12.50 3 0 0 0 0.04 +- 0.05 3 8

PF13481 (3/3) AAA domain
PF13408 (3/3) Recombinase zinc beta ribbon domain
PF10935 (3/3) Protein of unknown function (DUF2637)
PF07508 (3/3) Recombinase
PF05713 (3/3) Bacterial mobilisation protein (MobC)
PF00772 (3/3) DnaB-like helicase N terminal domain
PF00239 (3/3) Resolvase, N terminal domain
PF03432 (2/3) Relaxase/Mobilisation nuclease domain
jaccard_groups_201 74.66 +- 99.22 13 0 0 0 0.09 +- 0.17 13 4

PF14016 (13/13) Protein of unknown function (DUF4232)
TIGR04267 (10/13) HEXXH motif domain
PF08962 (10/13) Domain of unknown function (DUF1876)
PF00156 (10/13) Phosphoribosyl transferase domain
jaccard_groups_2895 1164.00 +- 384.00 3 1 2 3 0.01 +- 0.00 2 9

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR03975 (2/3) ribosomal peptide maturation radical SAM protein 1
TIGR03891 (2/3) thiopeptide-type bacteriocin biosynthesis domain
PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
jaccard_groups_2897 151.16 +- 141.34 2 0 1 0 0.09 +- 0.13 2 4

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00106 (2/2) short chain dehydrogenase
PF09346 (1/2) SMI1 / KNR4 family (SUKH-1)
PF00069 (1/2) Protein kinase domain
jaccard_groups_2892 21.62 +- 13.90 4 0 0 0 0.14 +- 0.14 4 3

TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF13302 (3/4) Acetyltransferase (GNAT) domain
jaccard_groups_3373 460.22 +- 221.87 3 0 0 0 0.02 +- 0.01 3 8

PF14759 (3/3) Reductase C-terminal
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00866 (3/3) Ring hydroxylating beta subunit
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00106 (3/3) short chain dehydrogenase
jaccard_groups_3370 462.55 +- 341.69 7 0 0 0 0.05 +- 0.10 7 18

TIGR01088 (7/7) 3-dehydroquinate dehydratase, type II
PF18317 (7/7) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (7/7) IclR helix-turn-helix domain
PF08501 (7/7) Shikimate dehydrogenase substrate binding domain
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF02627 (7/7) Carboxymuconolactone decarboxylase family
PF01614 (7/7) Bacterial transcriptional regulator
PF01557 (7/7) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (7/7) Xylose isomerase-like TIM barrel
PF01220 (7/7) Dehydroquinase class II
PF00903 (7/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (7/7) HMGL-like
PF00083 (7/7) Sugar (and other) transporter
TIGR03217 (6/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (6/7) acetaldehyde dehydrogenase (acetylating)
PF09290 (6/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (6/7) Semialdehyde dehydrogenase, NAD binding domain
jaccard_groups_3823 149.55 +- 64.04 3 0 0 0 0.04 +- 0.03 3 8

PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04972 (3/3) BON domain
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF00571 (3/3) CBS domain
PF13305 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_2169 288.76 +- 326.39 16 0 0 0 0.09 +- 0.22 16 12

PF03706 (16/16) Lysylphosphatidylglycerol synthase TM region
PF03372 (16/16) Endonuclease/Exonuclease/phosphatase family
PF01370 (16/16) NAD dependent epimerase/dehydratase family
PF01040 (16/16) UbiA prenyltransferase family
PF00535 (16/16) Glycosyl transferase family 2
PF00248 (16/16) Aldo/keto reductase family
PF00202 (16/16) Aminotransferase class-III
PF00196 (15/16) Bacterial regulatory proteins, luxR family
PF11755 (9/16) Protein of unknown function (DUF3311)
PF00583 (9/16) Acetyltransferase (GNAT) family
PF00474 (9/16) Sodium:solute symporter family
PF03176 (8/16) MMPL family
jaccard_groups_6132 1529.06 +- 164.06 2 0 2 2 0.01 +- 0.00 2 12

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04072 (2/2) Leucine carboxyl methyltransferase
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02441 (2/2) Flavoprotein
PF02195 (2/2) ParB-like nuclease domain
PF00881 (2/2) Nitroreductase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF06779 (1/2) Uncharacterised MFS-type transporter YbfB
jaccard_groups_2164 287.41 +- 243.08 5 0 2 0 0.02 +- 0.04 5 8

TIGR00566 (5/5) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (5/5) aminodeoxychorismate synthase, component I
PF04715 (5/5) Anthranilate synthase component I, N terminal region
PF00425 (5/5) chorismate binding enzyme
PF00117 (5/5) Glutamine amidotransferase class-I
TIGR01803 (3/5) chorismate mutase related enzymes
PF02153 (3/5) Prephenate dehydrogenase
PF01817 (3/5) Chorismate mutase type II
jaccard_groups_6136 511.00 +- 91.00 2 0 0 0 0.01 +- 0.01 2 8

TIGR01722 (2/2) methylmalonate-semialdehyde dehydrogenase (acylating)
PF11534 (2/2) Hexameric tyrosine-coordinated heme protein (HTHP)
PF07690 (2/2) Major Facilitator Superfamily
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_2167 164.03 +- 90.32 7 0 0 7 0.08 +- 0.20 7 8

TIGR04085 (7/7) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (7/7) Carbamoyltransferase C-terminus
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF05977 (7/7) Transmembrane secretion effector
PF02543 (7/7) Carbamoyltransferase N-terminus
PF13186 (6/7) Iron-sulfur cluster-binding domain
PF05721 (6/7) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (4/7) Radical SAM superfamily
jaccard_groups_6225 2387.67 +- 710.67 2 0 0 0 0.01 +- 0.00 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00673 (2/2) cyanase
PF13379 (2/2) NMT1-like family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02566 (2/2) OsmC-like protein
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01613 (2/2) Flavin reductase like domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
jaccard_groups_6223 19.83 +- 2.27 2 0 0 0 0.20 +- 0.36 2 7

TIGR00754 (2/2) bacterioferritin
PF09130 (2/2) Domain of unknown function (DUF1932)
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF00210 (2/2) Ferritin-like domain
PF10400 (1/2) Virulence activator alpha C-term
PF08922 (1/2) Domain of unknown function (DUF1905)
PF03551 (1/2) Transcriptional regulator PadR-like family
jaccard_groups_6222 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_6220 33.84 +- 0.11 2 0 2 0 0.15 +- 0.21 2 9

PF13439 (2/2) Glycosyltransferase Family 4
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF01638 (2/2) HxlR-like helix-turn-helix
PF00534 (2/2) Glycosyl transferases group 1
jaccard_groups_510 20.79 +- 1.91 4 0 0 0 0.22 +- 0.29 4 8

PF13452 (4/4) N-terminal half of MaoC dehydratase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01575 (4/4) MaoC like domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF12172 (3/4) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08924 (3/4) Domain of unknown function (DUF1906)
PF01796 (3/4) DUF35 OB-fold domain, acyl-CoA-associated
jaccard_groups_514 56.44 +- 4.73 2 0 1 0 0.15 +- 0.19 2 12

PF03636 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13185 (1/2) GAF domain
PF07730 (1/2) Histidine kinase
PF01522 (1/2) Polysaccharide deacetylase
PF00754 (1/2) F5/8 type C domain
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00582 (1/2) Universal stress protein family
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_3541 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family
jaccard_groups_2099 98.91 +- 93.88 12 0 0 0 0.12 +- 0.16 12 6

TIGR01840 (12/12) esterase, PHB depolymerase family
PF10503 (12/12) Esterase PHB depolymerase
PF07519 (12/12) Tannase and feruloyl esterase
PF10605 (11/12) 3HB-oligomer hydrolase (3HBOH)
PF13193 (8/12) AMP-binding enzyme C-terminal domain
PF00501 (8/12) AMP-binding enzyme
jaccard_groups_678 194.17 +- 53.48 3 0 0 0 0.02 +- 0.01 3 5

TIGR02365 (3/3) dihydroxyacetone kinase, L subunit
PF02734 (3/3) DAK2 domain
PF02733 (3/3) Dak1 domain
PF07690 (2/3) Major Facilitator Superfamily
PF00083 (2/3) Sugar (and other) transporter
jaccard_groups_677 122.53 +- 106.07 37 0 7 37 0.06 +- 0.09 37 4

PF13537 (37/37) Glutamine amidotransferase domain
PF00733 (37/37) Asparagine synthase
TIGR01536 (34/37) asparagine synthase (glutamine-hydrolyzing)
PF07690 (19/37) Major Facilitator Superfamily
jaccard_groups_2090 81.63 +- 27.44 3 0 0 0 0.17 +- 0.28 3 7

PF07730 (3/3) Histidine kinase
PF07690 (3/3) Major Facilitator Superfamily
PF01494 (3/3) FAD binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF02687 (2/3) FtsX-like permease family
PF00005 (2/3) ABC transporter
jaccard_groups_670 35.24 +- 31.75 3 0 1 0 0.22 +- 0.39 3 6

TIGR02644 (3/3) pyrimidine-nucleoside phosphorylase
PF13466 (3/3) STAS domain
PF07831 (3/3) Pyrimidine nucleoside phosphorylase C-terminal domain
PF02885 (3/3) Glycosyl transferase family, helical bundle domain
PF02608 (3/3) ABC transporter substrate-binding protein PnrA-like
PF00591 (3/3) Glycosyl transferase family, a/b domain
jaccard_groups_6357 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
jaccard_groups_6352 180.30 +- 87.44 2 0 0 0 0.07 +- 0.14 2 12

PF07730 (2/2) Histidine kinase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF03008 (2/2) Archaea bacterial proteins of unknown function
PF02687 (2/2) FtsX-like permease family
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF13424 (1/2) Tetratricopeptide repeat
PF13176 (1/2) Tetratricopeptide repeat
PF00931 (1/2) NB-ARC domain
jaccard_groups_3141 95.93 +- 59.81 3 0 0 0 0.12 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00144 (3/3) Beta-lactamase
PF18029 (2/3) Glyoxalase-like domain
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00210 (2/3) Ferritin-like domain
jaccard_groups_3145 39.15 +- 24.09 5 0 0 0 0.17 +- 0.14 5 7

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
PF05270 (5/5) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04542 (5/5) Sigma-70 region 2
PF03664 (5/5) Glycosyl hydrolase family 62
PF00331 (5/5) Glycosyl hydrolase family 10
PF14200 (4/5) Ricin-type beta-trefoil lectin domain-like
PF00652 (4/5) Ricin-type beta-trefoil lectin domain
jaccard_groups_3147 59.37 +- 29.26 5 0 0 0 0.08 +- 0.06 5 5

PF16653 (5/5) Saccharopine dehydrogenase C-terminal domain
PF05222 (5/5) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (5/5) Saccharopine dehydrogenase NADP binding domain
PF01266 (5/5) FAD dependent oxidoreductase
PF02423 (4/5) Ornithine cyclodeaminase/mu-crystallin family
jaccard_groups_2766 1186.36 +- 1618.96 5 0 1 0 0.08 +- 0.16 5 7

PF13407 (5/5) Periplasmic binding protein domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (5/5) ABC transporter
PF00106 (3/5) short chain dehydrogenase
jaccard_groups_4711 462.27 +- 130.14 3 0 0 0 0.01 +- 0.01 3 9

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF00487 (3/3) Fatty acid desaturase
PF00107 (3/3) Zinc-binding dehydrogenase
jaccard_groups_2941 189.68 +- 213.81 9 0 0 0 0.06 +- 0.11 9 7

TIGR01525 (9/9) heavy metal translocating P-type ATPase
PF07371 (9/9) Protein of unknown function (DUF1490)
PF01297 (9/9) Zinc-uptake complex component A periplasmic
PF00950 (9/9) ABC 3 transport family
PF00702 (9/9) haloacid dehalogenase-like hydrolase
PF00122 (9/9) E1-E2 ATPase
PF00005 (9/9) ABC transporter
jaccard_groups_2761 1099.00 +- 449.00 3 1 0 0 0.01 +- 0.00 2 6

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF01614 (3/3) Bacterial transcriptional regulator
PF00501 (3/3) AMP-binding enzyme
PF02515 (2/3) CoA-transferase family III
PF01144 (2/3) Coenzyme A transferase
jaccard_groups_471 30.64 +- 12.98 7 0 0 0 0.08 +- 0.09 7 2

PF03780 (7/7) Asp23 family, cell envelope-related function
PF00795 (4/7) Carbon-nitrogen hydrolase
jaccard_groups_470 49.43 +- 66.56 26 0 0 0 0.08 +- 0.13 26 5

PF17866 (26/26) AAA lid domain
PF13229 (26/26) Right handed beta helix region
PF00082 (26/26) Subtilase family
PF00004 (26/26) ATPase family associated with various cellular activities (AAA)
PF00652 (23/26) Ricin-type beta-trefoil lectin domain
jaccard_groups_473 120.88 +- 79.01 3 0 2 0 0.04 +- 0.05 3 2

PF02698 (3/3) DUF218 domain
PF08889 (2/3) WbqC-like protein family
jaccard_groups_472 265.75 +- 419.22 38 0 8 0 0.12 +- 0.14 38 4

PF00005 (38/38) ABC transporter
PF13343 (37/38) Bacterial extracellular solute-binding protein
PF08402 (37/38) TOBE domain
PF00528 (36/38) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4356 776.00 +- 2.83 3 0 0 0 0.01 +- 0.00 3 8

PF14759 (3/3) Reductase C-terminal
PF13279 (3/3) Thioesterase-like superfamily
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (3/3) Flavin reductase like domain
PF00775 (3/3) Dioxygenase
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (3/3) Cytochrome P450
jaccard_groups_2783 364.35 +- 214.06 10 0 1 2 0.03 +- 0.07 10 8

PF07690 (10/10) Major Facilitator Superfamily
PF03781 (10/10) Sulfatase-modifying factor enzyme 1
PF00925 (10/10) GTP cyclohydrolase II
PF00400 (10/10) WD domain, G-beta repeat
PF13424 (8/10) Tetratricopeptide repeat
PF03704 (8/10) Bacterial transcriptional activator domain
PF03358 (8/10) NADPH-dependent FMN reductase
PF00931 (8/10) NB-ARC domain
jaccard_groups_2546 12.72 +- 0.45 3 0 0 0 0.24 +- 0.38 3 7

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13560 (3/3) Helix-turn-helix domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08031 (3/3) Berberine and berberine like
PF04149 (3/3) Domain of unknown function (DUF397)
PF01565 (3/3) FAD binding domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
jaccard_groups_2231 31.54 +- 4.68 4 0 0 0 0.18 +- 0.13 4 9

PF14503 (4/4) YhfZ C-terminal domain
PF14502 (4/4) Helix-turn-helix domain
PF10941 (4/4) Protein of unknown function DUF2620
PF10797 (4/4) Protein of unknown function
PF02126 (4/4) Phosphotriesterase family
PF01676 (4/4) Metalloenzyme superfamily
PF01168 (4/4) Alanine racemase, N-terminal domain
PF00874 (4/4) PRD domain
PF00266 (3/4) Aminotransferase class-V
jaccard_groups_2232 33.88 +- 3.13 2 0 2 0 0.18 +- 0.28 2 11

TIGR01935 (2/2) RraA family
PF14378 (2/2) PAP2 superfamily
PF12222 (2/2) Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A
PF07730 (2/2) Histidine kinase
PF04226 (2/2) Transglycosylase associated protein
PF03737 (2/2) Aldolase/RraA
PF00494 (2/2) Squalene/phytoene synthase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
jaccard_groups_4158 24.02 +- 0.98 2 0 0 0 0.12 +- 0.15 2 6

PF01522 (2/2) Polysaccharide deacetylase
PF00106 (2/2) short chain dehydrogenase
PF13354 (1/2) Beta-lactamase enzyme family
PF05653 (1/2) Magnesium transporter NIPA
PF04672 (1/2) S-adenosyl methyltransferase
PF02342 (1/2) TerD domain
jaccard_groups_2234 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
jaccard_groups_2235 184.70 +- 53.45 14 0 2 0 0.12 +- 0.18 14 23

PF13191 (14/14) AAA ATPase domain
PF12697 (14/14) Alpha/beta hydrolase family
PF01547 (14/14) Bacterial extracellular solute-binding protein
PF00528 (14/14) Binding-protein-dependent transport system inner membrane component
PF00196 (14/14) Bacterial regulatory proteins, luxR family
PF17853 (13/14) GGDEF-like domain
PF14525 (13/14) AraC-binding-like domain
PF13556 (13/14) PucR C-terminal helix-turn-helix domain
PF12833 (13/14) Helix-turn-helix domain
PF07969 (13/14) Amidohydrolase family
PF07859 (13/14) alpha/beta hydrolase fold
PF07681 (13/14) DoxX
PF01184 (13/14) GPR1/FUN34/yaaH family
PF00857 (13/14) Isochorismatase family
PF00561 (13/14) alpha/beta hydrolase fold
PF00210 (13/14) Ferritin-like domain
PF14542 (12/14) GCN5-related N-acetyl-transferase
PF07992 (11/14) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (11/14) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
TIGR04037 (8/14) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (8/14) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF03358 (8/14) NADPH-dependent FMN reductase
PF00296 (8/14) Luciferase-like monooxygenase
jaccard_groups_2540 226.80 +- 223.37 12 0 0 12 0.03 +- 0.01 12 4

PF13480 (12/12) Acetyltransferase (GNAT) domain
PF04055 (12/12) Radical SAM superfamily
PF02492 (12/12) CobW/HypB/UreG, nucleotide-binding domain
PF13847 (11/12) Methyltransferase domain
jaccard_groups_2238 152.46 +- 41.04 2 0 2 0 0.01 +- 0.01 2 2

PF13810 (2/2) Domain of unknown function (DUF4185)
PF08310 (2/2) LGFP repeat
jaccard_groups_2239 192.15 +- 49.28 3 0 0 0 0.03 +- 0.04 3 4

TIGR01910 (3/3) peptidase, ArgE/DapE family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_5833 53.33 +- 11.17 2 0 0 0 0.11 +- 0.16 2 15

PF14871 (2/2) Hypothetical glycosyl hydrolase 6
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13602 (2/2) Zinc-binding dehydrogenase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08448 (2/2) PAS fold
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00989 (2/2) PAS fold
PF00457 (2/2) Glycosyl hydrolases family 11
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF03664 (1/2) Glycosyl hydrolase family 62
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
jaccard_groups_4401 5344.50 +- 176.64 4 0 4 4 0.01 +- 0.00 4 15

TIGR04267 (4/4) HEXXH motif domain
TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF14907 (4/4) Uncharacterised nucleotidyltransferase
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF13640 (4/4) 2OG-Fe(II) oxygenase superfamily
PF08241 (4/4) Methyltransferase domain
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF02223 (4/4) Thymidylate kinase
PF02195 (4/4) ParB-like nuclease domain
PF01909 (4/4) Nucleotidyltransferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00293 (4/4) NUDIX domain
PF00202 (4/4) Aminotransferase class-III
jaccard_groups_2438 141.19 +- 173.82 3 0 0 0 0.11 +- 0.19 3 3

PF08445 (3/3) FR47-like protein
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF00005 (3/3) ABC transporter
jaccard_groups_764 177.15 +- 57.52 3 0 0 0 0.01 +- 0.01 3 3

PF08924 (3/3) Domain of unknown function (DUF1906)
PF09362 (2/3) Domain of unknown function (DUF1996)
PF01471 (2/3) Putative peptidoglycan binding domain
jaccard_groups_2430 27.13 +- 9.89 3 0 0 0 0.13 +- 0.16 3 8

PF13671 (3/3) AAA domain
PF13563 (3/3) 2'-5' RNA ligase superfamily
PF09414 (3/3) RNA ligase
PF04928 (3/3) Poly(A) polymerase central domain
PF04457 (3/3) MJ1316 RNA cyclic group end recognition domain
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
TIGR03086 (2/3) TIGR03086 family protein
PF11716 (2/3) Mycothiol maleylpyruvate isomerase N-terminal domain
jaccard_groups_2431 323.36 +- 249.61 7 0 5 0 0.06 +- 0.13 7 7

PF06722 (7/7) Protein of unknown function (DUF1205)
PF03559 (7/7) NDP-hexose 2,3-dehydratase
PF00483 (7/7) Nucleotidyl transferase
TIGR01208 (6/7) glucose-1-phosphate thymidylyltransferase
TIGR01181 (6/7) dTDP-glucose 4,6-dehydratase
PF16363 (6/7) GDP-mannose 4,6 dehydratase
PF01408 (6/7) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_2436 83.27 +- 23.96 7 0 1 0 0.06 +- 0.04 7 4

PF10604 (7/7) Polyketide cyclase / dehydrase and lipid transport
PF03055 (6/7) Retinal pigment epithelial membrane protein
PF00440 (6/7) Bacterial regulatory proteins, tetR family
PF07690 (5/7) Major Facilitator Superfamily
jaccard_groups_767 187.37 +- 238.35 88 0 6 2 0.14 +- 0.17 88 6

PF09084 (87/88) NMT1/THI5 like
PF00528 (87/88) Binding-protein-dependent transport system inner membrane component
PF00005 (87/88) ABC transporter
PF00296 (86/88) Luciferase-like monooxygenase
TIGR03860 (83/88) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF02668 (66/88) Taurine catabolism dioxygenase TauD, TfdA family
jaccard_groups_5657 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF15607 (2/2) Bacterial toxin 44
PF12256 (2/2) Insecticide toxin TcdB middle/N-terminal region
PF05593 (2/2) RHS Repeat
PF03534 (2/2) Salmonella virulence plasmid 65kDa B protein
PF00561 (2/2) alpha/beta hydrolase fold
jaccard_groups_5656 105.07 +- 2.91 2 0 1 0 0.16 +- 0.26 2 18

PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07729 (2/2) FCD domain
PF05544 (2/2) Proline racemase
PF05195 (2/2) Aminopeptidase P, N-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00557 (2/2) Metallopeptidase family M24
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13808 (1/2) DDE_Tnp_1-associated
jaccard_groups_5655 61.70 +- 9.46 2 0 0 0 0.21 +- 0.27 2 13

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF14023 (2/2) Protein of unknown function (DUF4239)
PF14013 (2/2) MT0933-like antitoxin protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF13229 (2/2) Right handed beta helix region
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
PF01872 (1/2) RibD C-terminal domain
jaccard_groups_5658 285.84 +- 53.64 2 0 0 0 0.03 +- 0.01 2 13

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13229 (2/2) Right handed beta helix region
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07745 (2/2) Glycosyl hydrolase family 53
PF07224 (2/2) Chlorophyllase
PF04616 (2/2) Glycosyl hydrolases family 43
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF02371 (1/2) Transposase IS116/IS110/IS902 family
PF01548 (1/2) Transposase
jaccard_groups_691 21.76 +- 11.08 2 0 1 0 0.12 +- 0.23 2 12

TIGR01132 (2/2) phosphoglucomutase, alpha-D-glucose phosphate-specific
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF18029 (1/2) Glyoxalase-like domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05231 (1/2) MASE1
PF01471 (1/2) Putative peptidoglycan binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00075 (1/2) RNase H
jaccard_groups_695 27.00 +- 18.34 4 0 0 0 0.15 +- 0.21 4 6

PF04185 (4/4) Phosphoesterase family
PF05506 (3/4) Domain of unknown function (DUF756)
TIGR03396 (2/4) phospholipase C, phosphocholine-specific
PF13599 (2/4) Pentapeptide repeats (9 copies)
PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA)
PF00496 (2/4) Bacterial extracellular solute-binding proteins, family 5 Middle
jaccard_groups_694 191.35 +- 229.51 52 0 8 52 0.06 +- 0.12 52 10

TIGR02109 (52/52) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (52/52) Iron-sulfur cluster-binding domain
PF04055 (52/52) Radical SAM superfamily
TIGR02111 (51/52) coenzyme PQQ biosynthesis protein C
PF03070 (51/52) TENA/THI-4/PQQC family
PF12706 (48/52) Beta-lactamase superfamily domain
TIGR03859 (42/52) coenzyme PQQ biosynthesis protein PqqD
PF07995 (42/52) Glucose / Sorbosone dehydrogenase
PF05402 (42/52) Coenzyme PQQ synthesis protein D (PqqD)
TIGR02107 (37/52) coenzyme PQQ precursor peptide PqqA
jaccard_groups_5780 541.21 +- 462.12 2 0 2 0 0.08 +- 0.25 2 8

PF13732 (2/2) Domain of unknown function (DUF4162)
PF01061 (2/2) ABC-2 type transporter
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF01134 (1/2) Glucose inhibited division protein A
PF00561 (1/2) alpha/beta hydrolase fold
jaccard_groups_856 146.00 +- 88.40 6 0 0 0 0.03 +- 0.04 6 6

PF08223 (6/6) PaaX-like protein C-terminal domain
PF07848 (6/6) PaaX-like protein
PF13193 (3/6) AMP-binding enzyme C-terminal domain
PF07690 (3/6) Major Facilitator Superfamily
PF00534 (3/6) Glycosyl transferases group 1
PF00501 (3/6) AMP-binding enzyme
jaccard_groups_852 39.71 +- 13.00 4 0 0 0 0.16 +- 0.15 4 12

TIGR02429 (2/4) 3-oxoacid CoA-transferase, A subunit
TIGR02428 (2/4) 3-oxoacid CoA-transferase, B subunit
TIGR02423 (2/4) protocatechuate 3,4-dioxygenase, alpha subunit
TIGR02422 (2/4) protocatechuate 3,4-dioxygenase, beta subunit
TIGR01930 (2/4) acetyl-CoA C-acyltransferase
PF12391 (2/4) Protocatechuate 3,4-dioxygenase beta subunit N terminal
PF10397 (2/4) Adenylosuccinate lyase C-terminus
PF02803 (2/4) Thiolase, C-terminal domain
PF01144 (2/4) Coenzyme A transferase
PF00775 (2/4) Dioxygenase
PF00206 (2/4) Lyase
PF00108 (2/4) Thiolase, N-terminal domain
jaccard_groups_851 152.29 +- 196.96 11 0 0 0 0.10 +- 0.18 11 4

PF02837 (11/11) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (11/11) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (11/11) Glycosyl hydrolases family 2
PF00528 (7/11) Binding-protein-dependent transport system inner membrane component
jaccard_groups_850 99.60 +- 66.42 5 0 0 0 0.09 +- 0.17 5 3

PF12802 (5/5) MarR family
PF00583 (5/5) Acetyltransferase (GNAT) family
PF01261 (4/5) Xylose isomerase-like TIM barrel
jaccard_groups_859 272.87 +- 96.48 6 0 6 0 0.02 +- 0.02 6 7

TIGR01746 (6/6) thioester reductase domain
PF07993 (6/6) Male sterility protein
PF00501 (6/6) AMP-binding enzyme
PF13193 (5/6) AMP-binding enzyme C-terminal domain
PF00550 (5/6) Phosphopantetheine attachment site
PF00196 (4/6) Bacterial regulatory proteins, luxR family
PF00300 (3/6) Histidine phosphatase superfamily (branch 1)
jaccard_groups_858 23.42 +- 9.35 6 0 1 0 0.19 +- 0.28 6 4

TIGR00494 (6/6) protein CrcB
PF02641 (6/6) Uncharacterized ACR, COG1993
PF02537 (6/6) CrcB-like protein, Camphor Resistance (CrcB)
PF09594 (3/6) Glycosyltransferase family 87
jaccard_groups_5014 26.46 +- 1.39 2 0 0 0 0.11 +- 0.29 2 10

TIGR04267 (2/2) HEXXH motif domain
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF07075 (2/2) Protein of unknown function (DUF1343)
PF05547 (2/2) Immune inhibitor A peptidase M6
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00144 (2/2) Beta-lactamase
jaccard_groups_1200 372.51 +- 120.76 31 0 5 0 0.06 +- 0.17 31 14

TIGR01850 (31/31) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (31/31) RimK-like ATP-grasp domain
PF02779 (31/31) Transketolase, pyrimidine binding domain
PF01118 (31/31) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (31/31) Transketolase, thiamine diphosphate binding domain
TIGR01902 (30/31) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (30/31) Peptidase family M20/M25/M40
PF00696 (30/31) Amino acid kinase family
PF01041 (29/31) DegT/DnrJ/EryC1/StrS aminotransferase family
TIGR00768 (26/31) alpha-L-glutamate ligase, RimK family
PF18603 (25/31) L-amino acid ligase C-terminal domain 2
PF18130 (25/31) ATP-grasp N-terminal domain
PF13535 (25/31) ATP-grasp domain
PF07690 (25/31) Major Facilitator Superfamily
jaccard_groups_1201 311.62 +- 155.06 6 0 0 0 0.02 +- 0.10 6 11

TIGR01554 (6/6) phage major capsid protein, HK97 family
TIGR01543 (6/6) phage prohead protease, HK97 family
TIGR01537 (6/6) phage portal protein, HK97 family
PF05065 (6/6) Phage capsid family
PF04860 (6/6) Phage portal protein
PF04586 (6/6) Caudovirus prohead serine protease
PF01844 (6/6) HNH endonuclease
PF01510 (6/6) N-acetylmuramoyl-L-alanine amidase
PF09250 (3/6) Bifunctional DNA primase/polymerase, N-terminal
PF04851 (3/6) Type III restriction enzyme, res subunit
PF00271 (3/6) Helicase conserved C-terminal domain
jaccard_groups_5019 112.53 +- 104.80 3 0 0 0 0.05 +- 0.08 3 3

PF09848 (3/3) Uncharacterized conserved protein (DUF2075)
PF07728 (3/3) AAA domain (dynein-related subfamily)
PF00931 (2/3) NB-ARC domain
jaccard_groups_5018 232.51 +- 39.34 3 0 0 0 0.05 +- 0.09 3 11

TIGR00326 (3/3) riboflavin biosynthesis protein RibD
PF12894 (3/3) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (3/3) Major Facilitator Superfamily
PF07676 (3/3) WD40-like Beta Propeller Repeat
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (3/3) RibD C-terminal domain
PF00925 (3/3) GTP cyclohydrolase II
PF00400 (3/3) WD domain, G-beta repeat
PF00383 (3/3) Cytidine and deoxycytidylate deaminase zinc-binding region
TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13641 (2/3) Glycosyltransferase like family 2
jaccard_groups_3123 277.02 +- 107.44 3 0 3 0 0.04 +- 0.06 3 12

TIGR00654 (3/3) phenazine biosynthesis protein, PhzF family
PF10590 (3/3) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF03284 (3/3) Phenazine biosynthesis protein A/B
PF02567 (3/3) Phenazine biosynthesis-like protein
PF01474 (3/3) Class-II DAHP synthetase family
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00857 (3/3) Isochorismatase family
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF05199 (2/3) GMC oxidoreductase
PF00732 (2/3) GMC oxidoreductase
PF00171 (2/3) Aldehyde dehydrogenase family
jaccard_groups_3122 73.71 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR01472 (2/2) GDP-mannose 4,6-dehydratase
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13641 (2/2) Glycosyltransferase like family 2
PF05050 (2/2) Methyltransferase FkbM domain
PF04932 (2/2) O-Antigen ligase
jaccard_groups_3652 88.24 +- 7.83 2 0 2 0 0.11 +- 0.16 2 17

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17829 (2/2) Gylcosyl hydrolase family 115 C-terminal domain
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF15979 (2/2) Glycosyl hydrolase family 115
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08962 (2/2) Domain of unknown function (DUF1876)
PF07971 (2/2) Glycosyl hydrolase family 92
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00583 (2/2) Acetyltransferase (GNAT) family
PF14310 (1/2) Fibronectin type III-like domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_6462 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
jaccard_groups_6345 1424.50 +- 5.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR02946 (2/2) acyltransferase, WS/DGAT/MGAT
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06974 (2/2) Protein of unknown function (DUF1298)
PF03007 (2/2) Wax ester synthase-like Acyl-CoA acyltransferase domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
jaccard_groups_2702 61.73 +- 47.84 9 0 2 8 0.17 +- 0.18 9 13

TIGR01255 (9/9) formate acetyltransferase
PF02901 (9/9) Pyruvate formate lyase-like
PF01228 (9/9) Glycine radical
TIGR02493 (8/9) pyruvate formate-lyase 1-activating enzyme
PF04055 (8/9) Radical SAM superfamily
TIGR00886 (7/9) nitrite transporter
PF13247 (7/9) 4Fe-4S dicluster domain
PF07690 (7/9) Major Facilitator Superfamily
PF04879 (7/9) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (7/9) Molydopterin dinucleotide binding domain
PF00384 (7/9) Molybdopterin oxidoreductase
PF00355 (7/9) Rieske [2Fe-2S] domain
PF00037 (7/9) 4Fe-4S binding domain
jaccard_groups_6347 546.23 +- 485.77 2 0 0 0 0.06 +- 0.13 2 8

PF13377 (2/2) Periplasmic binding protein-like domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF12680 (1/2) SnoaL-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF00753 (1/2) Metallo-beta-lactamase superfamily
jaccard_groups_1448 102.26 +- 31.22 3 0 1 0 0.03 +- 0.03 3 5

PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF07690 (2/3) Major Facilitator Superfamily
PF00753 (2/3) Metallo-beta-lactamase superfamily
jaccard_groups_1330 82.08 +- 28.09 41 0 0 0 0.17 +- 0.22 41 19

PF13377 (41/41) Periplasmic binding protein-like domain
PF10022 (41/41) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (41/41) DeoR-like helix-turn-helix domain
PF02826 (41/41) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (41/41) Bacterial extracellular solute-binding protein
PF00528 (41/41) Binding-protein-dependent transport system inner membrane component
PF06628 (40/41) Catalase-related immune-responsive
PF06386 (40/41) Gas vesicle synthesis protein GvpL/GvpF
PF05121 (40/41) Gas vesicle protein K
PF05120 (40/41) Gas vesicle protein G
PF03364 (40/41) Polyketide cyclase / dehydrase and lipid transport
PF00741 (40/41) Gas vesicle protein
PF00199 (40/41) Catalase
PF18011 (39/41) C-terminal domain found in long catalases
PF05800 (39/41) Gas vesicle synthesis protein GvpO
PF13649 (31/41) Methyltransferase domain
PF00106 (29/41) short chain dehydrogenase
PF16859 (27/41) Tetracyclin repressor-like, C-terminal domain
PF00440 (27/41) Bacterial regulatory proteins, tetR family
jaccard_groups_1447 390.23 +- 677.19 17 0 17 0 0.09 +- 0.20 17 9

PF13561 (17/17) Enoyl-(Acyl carrier protein) reductase
PF07977 (17/17) FabA-like domain
PF01323 (17/17) DSBA-like thioredoxin domain
PF00109 (17/17) Beta-ketoacyl synthase, N-terminal domain
TIGR01830 (16/17) 3-oxoacyl-[acyl-carrier-protein] reductase
PF12697 (14/17) Alpha/beta hydrolase family
PF02801 (14/17) Beta-ketoacyl synthase, C-terminal domain
PF00550 (14/17) Phosphopantetheine attachment site
PF03621 (11/17) MbtH-like protein
jaccard_groups_1444 419.32 +- 244.77 39 0 39 0 0.04 +- 0.09 39 17

TIGR01733 (39/39) amino acid adenylation domain
PF13193 (39/39) AMP-binding enzyme C-terminal domain
PF07690 (39/39) Major Facilitator Superfamily
PF00550 (39/39) Phosphopantetheine attachment site
PF00501 (39/39) AMP-binding enzyme
PF03704 (37/39) Bacterial transcriptional activator domain
PF03621 (37/39) MbtH-like protein
PF00668 (37/39) Condensation domain
PF06224 (36/39) Winged helix DNA-binding domain
PF00975 (36/39) Thioesterase domain
PF00486 (36/39) Transcriptional regulatory protein, C terminal
PF00171 (36/39) Aldehyde dehydrogenase family
PF00067 (36/39) Cytochrome P450
PF02771 (35/39) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (35/39) Acyl-CoA dehydrogenase, middle domain
PF00441 (35/39) Acyl-CoA dehydrogenase, C-terminal domain
PF01648 (33/39) 4'-phosphopantetheinyl transferase superfamily
jaccard_groups_6045 214.34 +- 169.17 2 0 1 0 0.11 +- 0.28 2 18

TIGR00442 (2/2) histidine--tRNA ligase
TIGR00044 (2/2) pyridoxal phosphate enzyme, YggS family
PF13393 (2/2) Histidyl-tRNA synthetase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03129 (2/2) Anticodon binding domain
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01168 (2/2) Alanine racemase, N-terminal domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF13649 (1/2) Methyltransferase domain
PF08242 (1/2) Methyltransferase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00376 (1/2) MerR family regulatory protein
PF00334 (1/2) Nucleoside diphosphate kinase
jaccard_groups_4473 437.83 +- 296.52 4 0 0 0 0.04 +- 0.11 4 16

PF14226 (4/4) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (4/4) Methyltransferase domain
PF03781 (4/4) Sulfatase-modifying factor enzyme 1
PF03171 (4/4) 2OG-Fe(II) oxygenase superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00400 (4/4) WD domain, G-beta repeat
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
PF13570 (3/4) PQQ-like domain
PF12894 (3/4) Anaphase-promoting complex subunit 4 WD40 domain
PF18603 (2/4) L-amino acid ligase C-terminal domain 2
PF18130 (2/4) ATP-grasp N-terminal domain
PF18029 (2/4) Glyoxalase-like domain
PF13535 (2/4) ATP-grasp domain
PF07690 (2/4) Major Facilitator Superfamily
PF03358 (2/4) NADPH-dependent FMN reductase
jaccard_groups_4475 1022.81 +- 86.91 3 0 0 0 0.02 +- 0.02 3 14

PF14759 (3/3) Reductase C-terminal
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF04213 (3/3) Htaa
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00561 (3/3) alpha/beta hydrolase fold
PF00248 (3/3) Aldo/keto reductase family
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (3/3) Zinc-binding dehydrogenase
PF00067 (3/3) Cytochrome P450
TIGR04416 (2/3) group II intron reverse transcriptase/maturase
PF08388 (2/3) Group II intron, maturase-specific domain
PF00665 (2/3) Integrase core domain
PF00078 (2/3) Reverse transcriptase (RNA-dependent DNA polymerase)
jaccard_groups_1841 112.59 +- 59.41 2 0 1 0 0.04 +- 0.03 2 9

PF13229 (2/2) Right handed beta helix region
PF00754 (2/2) F5/8 type C domain
PF15780 (1/2) Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00041 (1/2) Fibronectin type III domain
jaccard_groups_1847 131.76 +- 113.57 9 0 4 0 0.07 +- 0.15 9 3

PF09265 (9/9) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF01565 (9/9) FAD binding domain
PF07228 (5/9) Stage II sporulation protein E (SpoIIE)
jaccard_groups_1025 37.41 +- 14.10 6 0 1 0 0.17 +- 0.14 6 9

PF16363 (6/6) GDP-mannose 4,6 dehydratase
PF12138 (6/6) Spherulation-specific family 4
PF11997 (6/6) Domain of unknown function (DUF3492)
PF03537 (6/6) Glycoside-hydrolase family GH114
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF00483 (6/6) Nucleotidyl transferase
PF13692 (3/6) Glycosyl transferases group 1
PF00534 (3/6) Glycosyl transferases group 1
PF00440 (3/6) Bacterial regulatory proteins, tetR family
jaccard_groups_1026 105.34 +- 91.68 4 0 0 0 0.05 +- 0.05 4 2

PF03459 (4/4) TOBE domain
TIGR00638 (2/4) molybdenum-pterin binding domain
jaccard_groups_1020 41.30 +- 11.97 36 0 0 0 0.11 +- 0.10 36 5

TIGR00456 (36/36) arginine--tRNA ligase
PF05746 (36/36) DALR anticodon binding domain
PF03485 (36/36) Arginyl tRNA synthetase N terminal domain
PF00750 (36/36) tRNA synthetases class I (R)
PF00561 (36/36) alpha/beta hydrolase fold
jaccard_groups_1022 35.15 +- 8.38 3 0 0 0 0.06 +- 0.09 3 3

PF10935 (3/3) Protein of unknown function (DUF2637)
PF01695 (3/3) IstB-like ATP binding protein
PF00239 (3/3) Resolvase, N terminal domain
jaccard_groups_1532 80.46 +- 42.34 4 0 0 0 0.07 +- 0.21 4 6

PF05222 (4/4) Alanine dehydrogenase/PNT, N-terminal domain
PF01262 (4/4) Alanine dehydrogenase/PNT, C-terminal domain
PF12697 (3/4) Alpha/beta hydrolase family
PF01494 (3/4) FAD binding domain
PF02909 (2/4) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/4) Bacterial regulatory proteins, tetR family
jaccard_groups_4075 1161.19 +- 530.18 4 0 4 4 0.02 +- 0.04 4 18

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (4/4) Thioesterase domain
PF00733 (4/4) Asparagine synthase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
TIGR00838 (2/4) argininosuccinate lyase
TIGR00032 (2/4) argininosuccinate synthase
PF14698 (2/4) Argininosuccinate lyase C-terminal
PF08028 (2/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00764 (2/4) Arginosuccinate synthase
PF00581 (2/4) Rhodanese-like domain
PF00578 (2/4) AhpC/TSA family
PF00206 (2/4) Lyase
jaccard_groups_4077 353.93 +- 253.66 3 0 3 0 0.06 +- 0.14 3 5

TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00107 (3/3) Zinc-binding dehydrogenase
PF07690 (2/3) Major Facilitator Superfamily
jaccard_groups_1535 112.03 +- 107.60 17 0 5 2 0.17 +- 0.25 17 6

PF13581 (17/17) Histidine kinase-like ATPase domain
PF13407 (17/17) Periplasmic binding protein domain
PF07228 (17/17) Stage II sporulation protein E (SpoIIE)
PF02653 (16/17) Branched-chain amino acid transport system / permease component
PF00005 (16/17) ABC transporter
PF13185 (9/17) GAF domain
jaccard_groups_1538 66.94 +- 20.18 33 0 0 0 0.11 +- 0.06 33 14

PF13561 (33/33) Enoyl-(Acyl carrier protein) reductase
PF07883 (33/33) Cupin domain
PF02776 (33/33) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (33/33) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00355 (33/33) Rieske [2Fe-2S] domain
PF00205 (33/33) Thiamine pyrophosphate enzyme, central domain
PF00175 (33/33) Oxidoreductase NAD-binding domain
PF00111 (33/33) 2Fe-2S iron-sulfur cluster binding domain
PF12697 (32/33) Alpha/beta hydrolase family
PF03447 (32/33) Homoserine dehydrogenase, NAD binding domain
PF01958 (32/33) Domain of unknown function DUF108
PF00903 (32/33) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00171 (32/33) Aldehyde dehydrogenase family
PF01042 (31/33) Endoribonuclease L-PSP
jaccard_groups_4079 462.24 +- 317.76 2 0 1 0 0.05 +- 0.20 2 14

TIGR03889 (2/2) nitrile hydratase accessory protein
TIGR03888 (2/2) nitrile hydratase, beta subunit
TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF13816 (2/2) Haem-containing dehydratase
PF09490 (2/2) Probable cobalt transporter subunit (CbtA)
PF09489 (2/2) Probable cobalt transporter subunit (CbtB)
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
PF01425 (2/2) Amidase
PF00501 (2/2) AMP-binding enzyme
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_3977 107.82 +- 38.90 5 0 5 0 0.18 +- 0.14 5 12

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13672 (5/5) Protein phosphatase 2C
PF13411 (5/5) MerR HTH family regulatory protein
PF09335 (5/5) SNARE associated Golgi protein
PF07944 (5/5) Beta-L-arabinofuranosidase, GH127
PF07730 (5/5) Histidine kinase
PF05448 (5/5) Acetyl xylan esterase (AXE1)
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
PF00005 (5/5) ABC transporter
jaccard_groups_3973 1236.40 +- 901.45 5 0 5 0 0.05 +- 0.19 5 24

TIGR03297 (5/5) phosphonopyruvate decarboxylase
TIGR02315 (5/5) phosphonate ABC transporter, ATP-binding protein
TIGR01356 (5/5) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (5/5) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR01098 (5/5) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (5/5) phosphonate ABC transporter, permease protein PhnE
PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF14765 (5/5) Polyketide synthase dehydratase
PF12974 (5/5) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF08659 (5/5) KR domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01676 (5/5) Metalloenzyme superfamily
PF00698 (5/5) Acyl transferase domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00275 (5/5) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (5/5) Glutamine amidotransferase class-I
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
PF00106 (5/5) short chain dehydrogenase
PF00005 (5/5) ABC transporter
PF00550 (4/5) Phosphopantetheine attachment site
jaccard_groups_3978 37.02 +- 9.98 5 0 0 0 0.14 +- 0.26 5 10

PF14542 (5/5) GCN5-related N-acetyl-transferase
PF12802 (5/5) MarR family
PF07690 (5/5) Major Facilitator Superfamily
PF05726 (5/5) Pirin C-terminal cupin domain
PF02678 (5/5) Pirin
PF01326 (5/5) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00089 (5/5) Trypsin
TIGR04036 (4/5) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF14559 (4/5) Tetratricopeptide repeat
PF00296 (4/5) Luciferase-like monooxygenase
jaccard_groups_5112 54.17 +- 15.06 3 0 0 0 0.17 +- 0.28 3 12

TIGR01581 (3/3) NifC-like ABC-type porter
TIGR00638 (3/3) molybdenum-pterin binding domain
PF12770 (3/3) CHAT domain
PF12728 (3/3) Helix-turn-helix domain
PF10590 (3/3) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF03459 (3/3) TOBE domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01494 (3/3) FAD binding domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
jaccard_groups_4218 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
jaccard_groups_4211 16.71 +- 2.62 4 0 1 0 0.15 +- 0.20 4 3

PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01427 (4/4) D-ala-D-ala dipeptidase
PF00795 (4/4) Carbon-nitrogen hydrolase
jaccard_groups_4212 318.77 +- 150.28 4 0 3 0 0.05 +- 0.07 4 7

TIGR00157 (4/4) ribosome small subunit-dependent GTPase A
PF13732 (4/4) Domain of unknown function (DUF4162)
PF13649 (4/4) Methyltransferase domain
PF03193 (4/4) RsgA GTPase
PF01061 (4/4) ABC-2 type transporter
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00005 (4/4) ABC transporter
jaccard_groups_2836 439.52 +- 312.43 8 0 0 0 0.09 +- 0.17 8 11

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF13378 (8/8) Enolase C-terminal domain-like
PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00150 (8/8) Cellulase (glycosyl hydrolase family 5)
TIGR02937 (7/8) RNA polymerase sigma factor, sigma-70 family
PF14200 (7/8) Ricin-type beta-trefoil lectin domain-like
PF04542 (7/8) Sigma-70 region 2
PF00652 (7/8) Ricin-type beta-trefoil lectin domain
PF14498 (6/8) Glycosyl hydrolase family 65, N-terminal domain
PF13561 (4/8) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_4271 346.20 +- 204.39 2 0 0 0 0.02 +- 0.02 2 8

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07993 (2/2) Male sterility protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_1155 294.68 +- 432.13 12 0 5 0 0.08 +- 0.12 12 5

PF07690 (12/12) Major Facilitator Superfamily
PF01047 (10/12) MarR family
TIGR01751 (6/12) crotonyl-CoA carboxylase/reductase
PF08240 (6/12) Alcohol dehydrogenase GroES-like domain
PF00107 (6/12) Zinc-binding dehydrogenase
jaccard_groups_1157 38.48 +- 28.48 14 0 6 0 0.11 +- 0.13 14 7

PF14361 (14/14) RsbT co-antagonist protein rsbRD N-terminal domain
PF07228 (14/14) Stage II sporulation protein E (SpoIIE)
PF01740 (14/14) STAS domain
PF02518 (12/14) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13581 (11/14) Histidine kinase-like ATPase domain
PF00512 (8/14) His Kinase A (phospho-acceptor) domain
PF00072 (8/14) Response regulator receiver domain
jaccard_groups_1158 73.93 +- 80.80 22 0 1 1 0.10 +- 0.07 22 8

PF13193 (22/22) AMP-binding enzyme C-terminal domain
PF00501 (22/22) AMP-binding enzyme
TIGR01217 (21/22) acetoacetate-CoA ligase
PF16177 (21/22) Acetyl-coenzyme A synthetase N-terminus
PF01557 (20/22) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (20/22) FAD binding domain
PF00903 (20/22) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13564 (15/22) DoxX-like family
jaccard_groups_4674 337.77 +- 33.50 2 0 2 0 0.21 +- 0.29 2 29

TIGR02246 (2/2) conserved hypothetical protein
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF12051 (2/2) Protein of unknown function (DUF3533)
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/2) Histidine kinase
PF04673 (2/2) Polyketide synthesis cyclase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00483 (2/2) Nucleotidyl transferase
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
jaccard_groups_4691 175.22 +- 37.62 2 0 0 0 0.07 +- 0.05 2 11

PF17912 (2/2) MalK OB fold domain
PF08402 (2/2) TOBE domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00005 (2/2) ABC transporter
PF03009 (1/2) Glycerophosphoryl diester phosphodiesterase family
jaccard_groups_4693 21.74 +- 2.70 2 0 0 0 0.14 +- 0.16 2 5

TIGR03356 (2/2) beta-galactosidase
PF08445 (2/2) FR47-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF06030 (2/2) Bacterial protein of unknown function (DUF916)
PF00232 (2/2) Glycosyl hydrolase family 1
jaccard_groups_2830 50.01 +- 21.34 4 0 0 0 0.17 +- 0.36 4 10

TIGR00086 (4/4) SsrA-binding protein
PF17820 (4/4) PDZ domain
PF14016 (4/4) Protein of unknown function (DUF4232)
PF03572 (4/4) Peptidase family S41
PF01668 (4/4) SmpB protein
TIGR01840 (3/4) esterase, PHB depolymerase family
TIGR00666 (3/4) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
TIGR00225 (3/4) C-terminal processing peptidase
PF10503 (3/4) Esterase PHB depolymerase
PF02113 (3/4) D-Ala-D-Ala carboxypeptidase 3 (S13) family
jaccard_groups_4699 143.87 +- 105.32 3 0 0 1 0.04 +- 0.04 3 3

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF00005 (3/3) ABC transporter
PF00719 (2/3) Inorganic pyrophosphatase
jaccard_groups_4856 254.25 +- 284.68 3 0 3 0 0.09 +- 0.24 3 9

TIGR04462 (3/3) enduracididine biosynthesis enzyme MppP
TIGR04460 (3/3) enduracididine biosynthesis enzyme MppR
PF12697 (3/3) Alpha/beta hydrolase family
PF06314 (3/3) Acetoacetate decarboxylase (ADC)
PF03621 (3/3) MbtH-like protein
PF03301 (3/3) Tryptophan 2,3-dioxygenase
PF00891 (3/3) O-methyltransferase domain
PF00535 (3/3) Glycosyl transferase family 2
PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_4501 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF04321 (2/2) RmlD substrate binding domain
PF02719 (2/2) Polysaccharide biosynthesis protein
PF00069 (2/2) Protein kinase domain
jaccard_groups_4855 468.39 +- 129.56 3 0 0 0 0.02 +- 0.01 3 7

TIGR02798 (3/3) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12697 (3/3) Alpha/beta hydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF03737 (3/3) Aldolase/RraA
PF02426 (3/3) Muconolactone delta-isomerase
PF02585 (2/3) GlcNAc-PI de-N-acetylase
jaccard_groups_4858 16.84 +- 1.44 2 0 0 0 0.18 +- 0.17 2 9

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF14525 (2/2) AraC-binding-like domain
PF14273 (2/2) Domain of unknown function (DUF4360)
PF12833 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00089 (2/2) Trypsin
jaccard_groups_3208 309.60 +- 206.40 2 0 2 0 0.01 +- 0.01 2 2

PF07722 (2/2) Peptidase C26
PF02627 (2/2) Carboxymuconolactone decarboxylase family
jaccard_groups_3204 139.83 +- 69.92 3 0 0 0 0.17 +- 0.35 3 27

TIGR02868 (3/3) thiol reductant ABC exporter, CydC subunit
TIGR02857 (3/3) thiol reductant ABC exporter, CydD subunit
TIGR02138 (3/3) phosphate ABC transporter, permease protein PstC
TIGR00974 (3/3) phosphate ABC transporter, permease protein PstA
TIGR00203 (3/3) cytochrome d ubiquinol oxidase, subunit II
PF13499 (3/3) EF-hand domain pair
PF13185 (3/3) GAF domain
PF12849 (3/3) PBP superfamily domain
PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF07730 (3/3) Histidine kinase
PF04203 (3/3) Sortase domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02322 (3/3) Cytochrome bd terminal oxidase subunit II
PF01654 (3/3) Cytochrome bd terminal oxidase subunit I
PF00672 (3/3) HAMP domain
PF00664 (3/3) ABC transporter transmembrane region
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
TIGR00458 (2/3) aspartate--tRNA(Asn) ligase
PF07411 (2/3) Domain of unknown function (DUF1508)
PF05685 (2/3) Putative restriction endonuclease
PF01336 (2/3) OB-fold nucleic acid binding domain
PF01135 (2/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00152 (2/3) tRNA synthetases class II (D, K and N)
jaccard_groups_3205 10.29 +- 0.89 3 0 3 0 0.19 +- 0.39 3 6

TIGR00876 (3/3) transaldolase
PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF01590 (3/3) GAF domain
PF00923 (3/3) Transaldolase/Fructose-6-phosphate aldolase
jaccard_groups_3200 296.34 +- 213.33 5 0 2 0 0.07 +- 0.22 5 26

TIGR02100 (5/5) glycogen debranching enzyme GlgX
TIGR01515 (5/5) 1,4-alpha-glucan branching enzyme
TIGR00377 (5/5) anti-anti-sigma factor
PF18085 (5/5) Maltokinase N-terminal cap domain
PF17124 (5/5) ThiJ/PfpI family-like
PF13614 (5/5) AAA domain
PF13581 (5/5) Histidine kinase-like ATPase domain
PF13546 (5/5) DDE superfamily endonuclease
PF13466 (5/5) STAS domain
PF13460 (5/5) NAD(P)H-binding
PF13380 (5/5) CoA binding domain
PF11896 (5/5) Domain of unknown function (DUF3416)
PF07690 (5/5) Major Facilitator Superfamily
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF07221 (5/5) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (5/5) EthD domain
PF02922 (5/5) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (5/5) DJ-1/PfpI family
PF01740 (5/5) STAS domain
PF00483 (5/5) Nucleotidyl transferase
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF00128 (5/5) Alpha amylase, catalytic domain
PF02806 (4/5) Alpha amylase, C-terminal all-beta domain
PF00132 (4/5) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_3201 158.14 +- 170.69 6 0 6 0 0.11 +- 0.20 6 6

PF08484 (6/6) C-methyltransferase C-terminal domain
PF08421 (6/6) Putative zinc binding domain
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF01061 (6/6) ABC-2 type transporter
PF00908 (6/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00005 (6/6) ABC transporter
jaccard_groups_219 125.82 +- 153.97 4 0 2 0 0.13 +- 0.26 4 8

PF17900 (4/4) Peptidase M1 N-terminal domain
PF01433 (4/4) Peptidase family M1 domain
TIGR02412 (2/4) aminopeptidase N
PF13434 (2/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF13384 (2/4) Homeodomain-like domain
PF11838 (2/4) ERAP1-like C-terminal domain
PF04402 (2/4) Protein of unknown function (DUF541)
PF00282 (2/4) Pyridoxal-dependent decarboxylase conserved domain
jaccard_groups_218 128.87 +- 100.15 8 0 2 0 0.05 +- 0.09 8 1

PF03372 (8/8) Endonuclease/Exonuclease/phosphatase family
jaccard_groups_217 103.25 +- 70.08 2 0 0 0 0.09 +- 0.16 2 7

PF14378 (2/2) PAP2 superfamily
PF09594 (2/2) Glycosyltransferase family 87
PF13692 (1/2) Glycosyl transferases group 1
PF08241 (1/2) Methyltransferase domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01471 (1/2) Putative peptidoglycan binding domain
PF01436 (1/2) NHL repeat
jaccard_groups_216 128.78 +- 190.96 65 0 19 0 0.06 +- 0.09 65 3

PF02776 (65/65) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF00205 (63/65) Thiamine pyrophosphate enzyme, central domain
PF02775 (62/65) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
jaccard_groups_210 158.52 +- 210.54 51 0 6 0 0.05 +- 0.09 51 1

PF01408 (51/51) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_212 85.54 +- 95.32 15 0 0 0 0.06 +- 0.07 15 1

PF00753 (15/15) Metallo-beta-lactamase superfamily
jaccard_groups_6128 18.49 +- 10.17 2 0 0 0 0.16 +- 0.28 2 6

TIGR01976 (2/2) cysteine desulfurase family protein
PF13560 (2/2) Helix-turn-helix domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00266 (2/2) Aminotransferase class-V
PF04134 (1/2) Protein of unknown function, DUF393
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
jaccard_groups_2159 114.10 +- 111.67 15 0 14 0 0.09 +- 0.24 15 6

PF13649 (15/15) Methyltransferase domain
PF03621 (15/15) MbtH-like protein
PF02668 (15/15) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (15/15) Aminotransferase class I and II
PF07592 (14/15) Rhodopirellula transposase DDE domain
PF13349 (13/15) Putative adhesin
jaccard_groups_6121 234.00 +- 26.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06259 (2/2) Alpha/beta hydrolase
jaccard_groups_2150 214.45 +- 99.62 17 0 0 0 0.07 +- 0.08 17 8

PF04909 (17/17) Amidohydrolase
PF01547 (17/17) Bacterial extracellular solute-binding protein
PF00528 (17/17) Binding-protein-dependent transport system inner membrane component
PF05336 (15/17) L-rhamnose mutarotase
PF08240 (14/17) Alcohol dehydrogenase GroES-like domain
PF00248 (10/17) Aldo/keto reductase family
PF00107 (10/17) Zinc-binding dehydrogenase
PF13561 (9/17) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_6127 163.69 +- 25.02 2 0 2 0 0.03 +- 0.02 2 11

TIGR03367 (2/2) queuosine biosynthesis protein QueD
TIGR00364 (2/2) queuosine biosynthesis protein QueC
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13394 (2/2) 4Fe-4S single cluster domain
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00487 (2/2) Fatty acid desaturase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_6235 2080.00 +- 260.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02597 (2/2) ThiS family
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF02310 (2/2) B12 binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_6236 497.18 +- 7.60 2 0 0 0 0.06 +- 0.15 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF13473 (2/2) Cupredoxin-like domain
PF12698 (2/2) ABC-2 family transporter protein
PF11666 (2/2) Protein of unknown function (DUF2933)
PF07690 (2/2) Major Facilitator Superfamily
PF04945 (2/2) YHS domain
PF04191 (2/2) Phospholipid methyltransferase
PF04012 (2/2) PspA/IM30 family
PF03713 (2/2) Domain of unknown function (DUF305)
PF01435 (2/2) Peptidase family M48
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
jaccard_groups_3371 129.78 +- 98.27 7 0 1 0 0.03 +- 0.04 7 4

TIGR00345 (7/7) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (7/7) 5TM C-terminal transporter carbon starvation CstA
PF02554 (7/7) Carbon starvation protein CstA
PF02374 (7/7) Anion-transporting ATPase
jaccard_groups_3374 22.32 +- 2.76 3 0 3 0 0.13 +- 0.09 3 5

TIGR02824 (3/3) putative NAD(P)H quinone oxidoreductase, PIG3 family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07859 (3/3) alpha/beta hydrolase fold
PF01965 (3/3) DJ-1/PfpI family
PF13602 (2/3) Zinc-binding dehydrogenase
jaccard_groups_3375 162.45 +- 95.56 4 0 1 0 0.04 +- 0.06 4 3

PF13649 (4/4) Methyltransferase domain
PF01494 (3/4) FAD binding domain
PF13460 (2/4) NAD(P)H-binding
jaccard_groups_500 32.05 +- 11.03 3 0 3 0 0.11 +- 0.09 3 2

PF02031 (3/3) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (3/3) LysE type translocator
jaccard_groups_502 77.93 +- 104.17 4 0 1 0 0.10 +- 0.12 4 2

PF04909 (4/4) Amidohydrolase
PF00083 (2/4) Sugar (and other) transporter
jaccard_groups_505 128.04 +- 19.61 4 0 0 0 0.02 +- 0.02 4 5

TIGR00180 (4/4) ParB/RepB/Spo0J family partition protein
PF13614 (4/4) AAA domain
PF02195 (4/4) ParB-like nuclease domain
PF03417 (3/4) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF00753 (3/4) Metallo-beta-lactamase superfamily
jaccard_groups_504 50.53 +- 68.69 17 0 0 0 0.18 +- 0.32 17 11

TIGR02103 (17/17) alpha-1,6-glucosidases, pullulanase-type
PF17967 (17/17) Pullulanase N2 domain
PF11852 (17/17) Domain of unknown function (DUF3372)
PF02922 (17/17) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (17/17) Alpha amylase, C-terminal all-beta domain
PF00128 (17/17) Alpha amylase, catalytic domain
PF03714 (16/17) Bacterial pullanase-associated domain
PF02962 (14/17) 5-carboxymethyl-2-hydroxymuconate isomerase
PF07228 (13/17) Stage II sporulation protein E (SpoIIE)
PF00072 (13/17) Response regulator receiver domain
PF00686 (12/17) Starch binding domain
jaccard_groups_509 266.33 +- 173.90 6 0 2 0 0.06 +- 0.10 6 4

PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF01613 (3/6) Flavin reductase like domain
PF00296 (3/6) Luciferase-like monooxygenase
jaccard_groups_3554 100.23 +- 46.69 3 0 0 0 0.06 +- 0.04 3 10

TIGR01930 (3/3) acetyl-CoA C-acyltransferase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02803 (3/3) Thiolase, C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF00108 (3/3) Thiolase, N-terminal domain
PF02737 (2/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00970 (2/3) Oxidoreductase FAD-binding domain
PF00725 (2/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_6349 101.85 +- 10.50 2 0 0 0 0.12 +- 0.16 2 17

PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF14587 (2/2) O-Glycosyl hydrolase family 30
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF14100 (2/2) Methane oxygenase PmoA
PF07883 (2/2) Cupin domain
PF03664 (2/2) Glycosyl hydrolase family 62
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00331 (2/2) Glycosyl hydrolase family 10
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04542 (1/2) Sigma-70 region 2
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
jaccard_groups_3791 667.24 +- 335.44 5 0 5 0 0.03 +- 0.06 5 14

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12832 (5/5) MFS_1 like family
PF01212 (5/5) Beta-eliminating lyase
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00156 (5/5) Phosphoribosyl transferase domain
PF00067 (5/5) Cytochrome P450
TIGR00229 (3/5) PAS domain S-box protein
PF08448 (3/5) PAS fold
PF07228 (3/5) Stage II sporulation protein E (SpoIIE)
PF01814 (3/5) Hemerythrin HHE cation binding domain
PF01590 (3/5) GAF domain
PF00989 (3/5) PAS fold
jaccard_groups_3792 136.38 +- 108.42 5 0 0 0 0.03 +- 0.07 5 6

PF13669 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF01494 (3/5) FAD binding domain
jaccard_groups_3793 47.14 +- 1.98 4 0 0 4 0.10 +- 0.08 4 5

PF13360 (4/4) PQQ-like domain
PF00069 (4/4) Protein kinase domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
PF04185 (3/4) Phosphoesterase family
jaccard_groups_3794 201.13 +- 62.99 5 0 5 5 0.09 +- 0.19 5 19

TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13537 (5/5) Glutamine amidotransferase domain
PF08592 (5/5) Domain of unknown function (DUF1772)
PF07883 (5/5) Cupin domain
PF04673 (5/5) Polyketide synthesis cyclase
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF03364 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00733 (5/5) Asparagine synthase
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
TIGR00924 (4/5) amino acid/peptide transporter (Peptide:H+ symporter)
PF03704 (4/5) Bacterial transcriptional activator domain
PF00931 (4/5) NB-ARC domain
PF00854 (4/5) POT family
PF00550 (4/5) Phosphopantetheine attachment site
PF00486 (4/5) Transcriptional regulatory protein, C terminal
PF00067 (4/5) Cytochrome P450
PF04672 (3/5) S-adenosyl methyltransferase
jaccard_groups_6341 128.60 +- 0.40 2 0 0 0 0.16 +- 0.33 2 15

PF13473 (2/2) Cupredoxin-like domain
PF13462 (2/2) Thioredoxin
PF13386 (2/2) Cytochrome C biogenesis protein transmembrane region
PF11303 (2/2) Protein of unknown function (DUF3105)
PF11292 (2/2) Protein of unknown function (DUF3093)
PF09678 (2/2) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF09490 (2/2) Probable cobalt transporter subunit (CbtA)
PF09489 (2/2) Probable cobalt transporter subunit (CbtB)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF00484 (2/2) Carbonic anhydrase
PF00403 (2/2) Heavy-metal-associated domain
jaccard_groups_3796 175.80 +- 132.70 5 0 0 0 0.04 +- 0.10 5 4

PF05901 (5/5) Excalibur calcium-binding domain
PF00293 (5/5) NUDIX domain
PF01738 (4/5) Dienelactone hydrolase family
PF00067 (3/5) Cytochrome P450
jaccard_groups_3156 1128.80 +- 378.64 5 0 0 0 0.01 +- 0.00 5 9

PF14525 (5/5) AraC-binding-like domain
PF12833 (5/5) Helix-turn-helix domain
PF11716 (5/5) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF01613 (5/5) Flavin reductase like domain
PF00296 (5/5) Luciferase-like monooxygenase
PF12680 (4/5) SnoaL-like domain
PF02653 (4/5) Branched-chain amino acid transport system / permease component
PF00005 (4/5) ABC transporter
jaccard_groups_3150 38.78 +- 14.21 5 0 0 5 0.11 +- 0.19 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF00881 (5/5) Nitroreductase family
PF10935 (3/5) Protein of unknown function (DUF2637)
jaccard_groups_3151 264.77 +- 134.67 6 0 2 0 0.03 +- 0.02 6 10

TIGR03105 (6/6) glutamine synthetase, type III
PF13522 (6/6) Glutamine amidotransferase domain
PF01645 (6/6) Conserved region in glutamate synthase
PF01493 (6/6) GXGXG motif
PF01266 (6/6) FAD dependent oxidoreductase
PF00120 (6/6) Glutamine synthetase, catalytic domain
TIGR00836 (4/6) ammonium transporter
PF07883 (4/6) Cupin domain
PF00909 (4/6) Ammonium Transporter Family
PF01381 (3/6) Helix-turn-helix
jaccard_groups_4367 783.81 +- 506.19 2 0 0 0 0.03 +- 0.07 2 11

TIGR03544 (2/2) DivIVA domain
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF05103 (2/2) DivIVA protein
PF01545 (2/2) Cation efflux family
PF16995 (1/2) Transmembrane region of lysyl-tRNA synthetase
PF09924 (1/2) Uncharacterised conserved protein (DUF2156)
PF08239 (1/2) Bacterial SH3 domain
PF07690 (1/2) Major Facilitator Superfamily
PF01252 (1/2) Signal peptidase (SPase) II
PF00756 (1/2) Putative esterase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_3159 205.77 +- 128.64 8 0 1 0 0.07 +- 0.15 8 8

PF12833 (8/8) Helix-turn-helix domain
PF02774 (8/8) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (8/8) DJ-1/PfpI family
PF01118 (8/8) Semialdehyde dehydrogenase, NAD binding domain
PF00196 (8/8) Bacterial regulatory proteins, luxR family
PF00171 (8/8) Aldehyde dehydrogenase family
PF00696 (7/8) Amino acid kinase family
PF00465 (7/8) Iron-containing alcohol dehydrogenase
jaccard_groups_449 78.95 +- 87.78 39 0 4 0 0.07 +- 0.14 39 3

PF12277 (39/39) Protein of unknown function (DUF3618)
PF07332 (39/39) Putative Actinobacterial Holin-X, holin superfamily III
PF14019 (33/39) Protein of unknown function (DUF4235)
jaccard_groups_445 341.87 +- 210.82 3 0 1 0 0.07 +- 0.24 3 3

PF00326 (3/3) Prolyl oligopeptidase family
PF07690 (2/3) Major Facilitator Superfamily
PF00067 (2/3) Cytochrome P450
jaccard_groups_446 133.52 +- 113.90 2 0 0 0 0.05 +- 0.07 2 12

TIGR01613 (2/2) phage/plasmid primase, P4 family, C-terminal domain
PF08706 (2/2) D5 N terminal like
PF03288 (2/2) Poxvirus D5 protein-like
TIGR04538 (1/2) cytochrome P450, cyclodipeptide synthase-associated
TIGR00180 (1/2) ParB/RepB/Spo0J family partition protein
PF13646 (1/2) HEAT repeats
PF13614 (1/2) AAA domain
PF11774 (1/2) Lsr2
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF07690 (1/2) Major Facilitator Superfamily
PF02195 (1/2) ParB-like nuclease domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_447 18.77 +- 0.34 4 0 0 0 0.21 +- 0.39 4 12

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
TIGR00209 (4/4) galactose-1-phosphate uridylyltransferase
TIGR00131 (4/4) galactokinase
PF14099 (4/4) Polysaccharide lyase
PF10509 (4/4) Galactokinase galactose-binding signature
PF08544 (4/4) GHMP kinases C terminal
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF02744 (4/4) Galactose-1-phosphate uridyl transferase, C-terminal domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01087 (4/4) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF00455 (4/4) DeoR C terminal sensor domain
PF00288 (4/4) GHMP kinases N terminal domain
jaccard_groups_441 187.43 +- 267.37 6 0 1 1 0.09 +- 0.16 6 11

TIGR02243 (6/6) putative baseplate assembly protein
TIGR02241 (6/6) conserved hypothetical phage tail region protein
PF06841 (6/6) T4-like virus tail tube protein gp19
PF04965 (6/6) Gene 25-like lysozyme
PF17482 (5/6) Phage tail sheath C-terminal domain
PF14065 (5/6) Protein of unknown function (DUF4255)
PF13699 (5/6) Domain of unknown function (DUF4157)
PF04984 (5/6) Phage tail sheath protein subtilisin-like domain
PF04865 (5/6) Baseplate J-like protein
PF00004 (5/6) ATPase family associated with various cellular activities (AAA)
PF01476 (3/6) LysM domain
jaccard_groups_997 110.60 +- 128.96 8 0 2 0 0.07 +- 0.16 8 3

PF18593 (8/8) CdiI immunity protein
PF18431 (8/8) Bacterial CdiA-CT RNAse A domain
PF06013 (8/8) Proteins of 100 residues with WXG
jaccard_groups_994 251.87 +- 72.91 7 0 0 0 0.03 +- 0.11 7 16

TIGR01558 (7/7) putative phage terminase, small subunit, P27 family
TIGR01554 (7/7) phage major capsid protein, HK97 family
TIGR01543 (7/7) phage prohead protease, HK97 family
TIGR01537 (7/7) phage portal protein, HK97 family
PF10145 (7/7) Phage-related minor tail protein
PF05119 (7/7) Phage terminase, small subunit
PF05065 (7/7) Phage capsid family
PF04860 (7/7) Phage portal protein
PF04586 (7/7) Caudovirus prohead serine protease
PF03354 (7/7) Phage Terminase
PF01510 (6/7) N-acetylmuramoyl-L-alanine amidase
PF01381 (6/7) Helix-turn-helix
PF16945 (4/7) Putative lactococcus lactis phage r1t holin
PF13229 (4/7) Right handed beta helix region
PF01476 (4/7) LysM domain
PF01464 (4/7) Transglycosylase SLT domain
jaccard_groups_992 163.86 +- 159.65 3 0 0 0 0.08 +- 0.12 3 4

PF16192 (3/3) C-terminal four TMM region of protein-O-mannosyltransferase
PF02366 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF05223 (2/3) NTF2-like N-terminal transpeptidase domain
PF00905 (2/3) Penicillin binding protein transpeptidase domain
jaccard_groups_993 168.75 +- 157.01 60 0 4 0 0.05 +- 0.06 60 10

PF07690 (59/60) Major Facilitator Superfamily
PF03771 (59/60) Domain of unknown function (DUF317)
PF01638 (58/60) HxlR-like helix-turn-helix
PF13535 (52/60) ATP-grasp domain
PF16259 (51/60) Domain of unknown function (DUF4913)
PF17802 (50/60) Prealbumin-like fold domain
PF08239 (46/60) Bacterial SH3 domain
PF18130 (45/60) ATP-grasp N-terminal domain
PF01555 (44/60) DNA methylase
TIGR01167 (34/60) LPXTG cell wall anchor domain
jaccard_groups_991 59.35 +- 34.78 2 0 0 0 0.13 +- 0.18 2 7

PF13091 (2/2) PLD-like domain
PF11907 (2/2) Domain of unknown function (DUF3427)
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02810 (2/2) SEC-C motif
PF00296 (2/2) Luciferase-like monooxygenase
PF00271 (2/2) Helicase conserved C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_999 217.74 +- 45.15 4 0 3 4 0.01 +- 0.00 4 4

TIGR01444 (4/4) methyltransferase, FkbM family
PF05050 (4/4) Methyltransferase FkbM domain
PF04055 (4/4) Radical SAM superfamily
PF02310 (4/4) B12 binding domain
jaccard_groups_2204 115.14 +- 110.03 9 0 0 3 0.07 +- 0.05 9 11

PF17801 (9/9) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (9/9) Alpha galactosidase A
PF07995 (9/9) Glucose / Sorbosone dehydrogenase
PF07470 (9/9) Glycosyl Hydrolase Family 88
PF03422 (9/9) Carbohydrate binding module (family 6)
PF01120 (9/9) Alpha-L-fucosidase
PF00754 (9/9) F5/8 type C domain
PF00041 (8/9) Fibronectin type III domain
PF14099 (7/9) Polysaccharide lyase
PF00295 (6/9) Glycosyl hydrolases family 28
PF00704 (5/9) Glycosyl hydrolases family 18
jaccard_groups_2206 140.05 +- 83.24 6 0 1 0 0.05 +- 0.05 6 6

PF13460 (5/6) NAD(P)H-binding
PF00561 (5/6) alpha/beta hydrolase fold
TIGR00711 (4/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07992 (4/6) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/6) Major Facilitator Superfamily
PF01494 (3/6) FAD binding domain
jaccard_groups_2203 285.51 +- 269.10 13 0 13 0 0.10 +- 0.22 13 19

PF00005 (13/13) ABC transporter
TIGR01733 (12/13) amino acid adenylation domain
PF13193 (12/13) AMP-binding enzyme C-terminal domain
PF03621 (12/13) MbtH-like protein
PF02797 (12/13) Chalcone and stilbene synthases, C-terminal domain
PF02518 (12/13) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (12/13) HAMP domain
PF00668 (12/13) Condensation domain
PF00664 (12/13) ABC transporter transmembrane region
PF00512 (12/13) His Kinase A (phospho-acceptor) domain
PF00501 (12/13) AMP-binding enzyme
PF00378 (12/13) Enoyl-CoA hydratase/isomerase
PF00195 (12/13) Chalcone and stilbene synthases, N-terminal domain
PF00155 (12/13) Aminotransferase class I and II
PF02153 (11/13) Prephenate dehydrogenase
PF01070 (11/13) FMN-dependent dehydrogenase
PF00550 (11/13) Phosphopantetheine attachment site
PF12697 (10/13) Alpha/beta hydrolase family
TIGR01720 (8/13) non-ribosomal peptide synthase domain TIGR01720
jaccard_groups_2202 58.36 +- 48.16 7 0 0 0 0.11 +- 0.20 7 7

PF07690 (7/7) Major Facilitator Superfamily
PF03466 (7/7) LysR substrate binding domain
PF00126 (7/7) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR00710 (6/7) drug resistance transporter, Bcr/CflA subfamily
PF02826 (6/7) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01361 (6/7) Tautomerase enzyme
PF00553 (6/7) Cellulose binding domain
jaccard_groups_2209 810.60 +- 160.00 8 0 8 0 0.02 +- 0.10 8 27

TIGR01850 (8/8) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (8/8) amino acid adenylation domain
TIGR00761 (8/8) acetylglutamate kinase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF01546 (8/8) Peptidase family M20/M25/M40
PF01118 (8/8) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (8/8) Amino acid kinase family
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
TIGR01902 (6/8) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF13561 (6/8) Enoyl-(Acyl carrier protein) reductase
PF08443 (6/8) RimK-like ATP-grasp domain
PF02774 (6/8) Semialdehyde dehydrogenase, dimerisation domain
TIGR01206 (5/8) lysine biosynthesis protein LysW
TIGR00768 (5/8) alpha-L-glutamate ligase, RimK family
PF16197 (5/8) Ketoacyl-synthetase C-terminal extension
PF08659 (5/8) KR domain
PF07993 (5/8) Male sterility protein
PF03621 (5/8) MbtH-like protein
PF02801 (5/8) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/8) Acyl transferase domain
PF00109 (5/8) Beta-ketoacyl synthase, N-terminal domain
PF14399 (4/8) Butirosin biosynthesis protein H, N-terminal
PF02771 (4/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/8) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/8) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_2330 316.43 +- 439.21 13 0 13 1 0.11 +- 0.15 13 17

TIGR01733 (13/13) amino acid adenylation domain
PF18563 (13/13) TubC N-terminal docking domain
PF13193 (13/13) AMP-binding enzyme C-terminal domain
PF08242 (13/13) Methyltransferase domain
PF00975 (13/13) Thioesterase domain
PF00668 (13/13) Condensation domain
PF00664 (13/13) ABC transporter transmembrane region
PF00550 (13/13) Phosphopantetheine attachment site
PF00501 (13/13) AMP-binding enzyme
PF00005 (13/13) ABC transporter
TIGR01761 (12/13) thiazolinyl imide reductase
PF01408 (12/13) Oxidoreductase family, NAD-binding Rossmann fold
PF03435 (11/13) Saccharopine dehydrogenase NADP binding domain
TIGR03494 (10/13) salicylate synthase
PF13649 (10/13) Methyltransferase domain
PF00425 (10/13) chorismate binding enzyme
PF00067 (10/13) Cytochrome P450
jaccard_groups_2840 34.31 +- 35.67 5 0 0 0 0.14 +- 0.22 5 5

PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (5/5) Cellulose binding domain
PF12900 (4/5) Pyridoxamine 5'-phosphate oxidase
PF13377 (3/5) Periplasmic binding protein-like domain
PF00356 (3/5) Bacterial regulatory proteins, lacI family
jaccard_groups_2847 146.86 +- 132.06 6 0 3 0 0.11 +- 0.23 6 9

PF10633 (6/6) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01074 (6/6) Glycosyl hydrolases family 38 N-terminal domain
PF13377 (5/6) Periplasmic binding protein-like domain
PF09261 (5/6) Alpha mannosidase middle domain
PF00356 (5/6) Bacterial regulatory proteins, lacI family
PF03644 (4/6) Glycosyl hydrolase family 85
PF00754 (4/6) F5/8 type C domain
PF18029 (3/6) Glyoxalase-like domain
PF00720 (3/6) Subtilisin inhibitor-like
jaccard_groups_2846 189.94 +- 64.98 3 0 0 0 0.04 +- 0.04 3 9

PF14552 (3/3) Tautomerase enzyme
PF12706 (3/3) Beta-lactamase superfamily domain
PF03466 (3/3) LysR substrate binding domain
PF01361 (3/3) Tautomerase enzyme
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF13546 (2/3) DDE superfamily endonuclease
PF07859 (2/3) alpha/beta hydrolase fold
PF07690 (2/3) Major Facilitator Superfamily
PF03060 (2/3) Nitronate monooxygenase
jaccard_groups_2844 233.60 +- 80.20 10 0 1 0 0.03 +- 0.03 10 8

PF07690 (10/10) Major Facilitator Superfamily
PF00155 (10/10) Aminotransferase class I and II
PF00106 (10/10) short chain dehydrogenase
PF03746 (9/10) LamB/YcsF family
PF02682 (9/10) Carboxyltransferase domain, subdomain C and D
PF02626 (9/10) Carboxyltransferase domain, subdomain A and B
PF00083 (7/10) Sugar (and other) transporter
PF00440 (6/10) Bacterial regulatory proteins, tetR family
jaccard_groups_5536 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_2849 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
jaccard_groups_5824 2338.97 +- 241.03 2 0 0 0 0.01 +- 0.02 2 10

PF12680 (2/2) SnoaL-like domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00005 (2/2) ABC transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01494 (1/2) FAD binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
jaccard_groups_5531 413.36 +- 321.43 2 0 1 0 0.06 +- 0.21 2 21

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF09339 (1/2) IclR helix-turn-helix domain
PF06974 (1/2) Protein of unknown function (DUF1298)
PF03007 (1/2) Wax ester synthase-like Acyl-CoA acyltransferase domain
PF01614 (1/2) Bacterial transcriptional regulator
PF01039 (1/2) Carboxyl transferase domain
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
jaccard_groups_2449 298.48 +- 222.29 9 0 3 0 0.07 +- 0.15 9 13

PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF01959 (8/9) 3-dehydroquinate synthase II
PF01791 (8/9) DeoC/LacD family aldolase
PF01370 (7/9) NAD dependent epimerase/dehydratase family
PF13561 (6/9) Enoyl-(Acyl carrier protein) reductase
PF13454 (6/9) FAD-NAD(P)-binding
PF10397 (6/9) Adenylosuccinate lyase C-terminus
PF07690 (6/9) Major Facilitator Superfamily
PF00206 (6/9) Lyase
jaccard_groups_2842 104.44 +- 98.23 8 0 0 0 0.09 +- 0.13 8 4

TIGR03666 (8/8) PPOX class probable F420-dependent enzyme, Rv2061 family
PF01243 (8/8) Pyridoxamine 5'-phosphate oxidase
PF07690 (7/8) Major Facilitator Superfamily
PF00171 (6/8) Aldehyde dehydrogenase family
jaccard_groups_2445 41.59 +- 26.30 2 0 1 0 0.07 +- 0.15 2 4

PF13649 (2/2) Methyltransferase domain
PF00248 (2/2) Aldo/keto reductase family
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF10901 (1/2) Protein of unknown function (DUF2690)
jaccard_groups_2444 202.15 +- 109.88 9 0 9 0 0.02 +- 0.01 9 7

TIGR04475 (9/9) phenylalanine aminomutase (D-beta-phenylalanine forming)
PF14534 (9/9) Domain of unknown function (DUF4440)
PF13977 (9/9) BetI-type transcriptional repressor, C-terminal
PF13459 (9/9) 4Fe-4S single cluster domain
PF00440 (9/9) Bacterial regulatory proteins, tetR family
PF00221 (9/9) Aromatic amino acid lyase
PF00067 (9/9) Cytochrome P450
jaccard_groups_2441 285.26 +- 125.26 2 0 1 0 0.02 +- 0.02 2 7

TIGR00414 (2/2) serine--tRNA ligase
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF02403 (2/2) Seryl-tRNA synthetase N-terminal domain
PF01941 (2/2) S-adenosylmethionine synthetase (AdoMet synthetase)
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00534 (1/2) Glycosyl transferases group 1
jaccard_groups_5316 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
jaccard_groups_5646 212.96 +- 84.74 2 0 2 0 0.05 +- 0.07 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01510 (2/2) pantetheine-phosphate adenylyltransferase
PF13646 (2/2) HEAT repeats
PF13411 (2/2) MerR HTH family regulatory protein
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02310 (2/2) B12 binding domain
PF01467 (2/2) Cytidylyltransferase-like
PF00857 (2/2) Isochorismatase family
PF02607 (1/2) B12 binding domain
jaccard_groups_1715 273.27 +- 38.73 2 0 2 0 0.01 +- 0.01 2 6

PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF05977 (2/2) Transmembrane secretion effector
PF04183 (2/2) IucA / IucC family
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF13228 (1/2) Domain of unknown function (DUF4037)
PF01909 (1/2) Nucleotidyltransferase domain
jaccard_groups_5224 1293.33 +- 4.71 3 0 3 3 0.01 +- 0.00 3 6

PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF01928 (3/3) CYTH domain
PF01523 (3/3) Putative modulator of DNA gyrase
PF01061 (3/3) ABC-2 type transporter
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
jaccard_groups_1712 130.98 +- 82.27 14 0 4 0 0.13 +- 0.23 14 17

TIGR03217 (14/14) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (14/14) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (14/14) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (14/14) 3-hydroxyanthranilate 3,4-dioxygenase
PF09290 (14/14) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (14/14) DmpG-like communication domain
PF06052 (14/14) 3-hydroxyanthranilic acid dioxygenase
PF04909 (14/14) Amidohydrolase
PF01557 (14/14) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (14/14) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (14/14) Endoribonuclease L-PSP
PF00682 (14/14) HMGL-like
PF00171 (14/14) Aldehyde dehydrogenase family
TIGR01814 (12/14) kynureninase
PF00324 (12/14) Amino acid permease
PF00266 (12/14) Aminotransferase class-V
PF08309 (10/14) LVIVD repeat
jaccard_groups_2336 30.80 +- 11.11 9 0 0 0 0.12 +- 0.26 9 3

TIGR03296 (9/9) M6 family metalloprotease domain
PF09339 (9/9) IclR helix-turn-helix domain
PF03777 (9/9) ChpA-C
jaccard_groups_5796 157.48 +- 95.83 2 0 0 0 0.11 +- 0.16 2 9

TIGR03707 (2/2) polyphosphate kinase 2
TIGR02315 (2/2) phosphonate ABC transporter, ATP-binding protein
TIGR01098 (2/2) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (2/2) phosphonate ABC transporter, permease protein PhnE
PF12974 (2/2) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF01384 (2/2) Phosphate transporter family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
jaccard_groups_1711 28.13 +- 20.87 9 0 0 0 0.15 +- 0.15 9 7

TIGR00344 (9/9) alanine--tRNA ligase
PF07973 (9/9) Threonyl and Alanyl tRNA synthetase second additional domain
PF02272 (9/9) DHHA1 domain
PF01411 (9/9) tRNA synthetases class II (A)
PF00583 (7/9) Acetyltransferase (GNAT) family
TIGR03723 (6/9) tRNA threonylcarbamoyl adenosine modification protein TsaD
PF00814 (6/9) Glycoprotease family
jaccard_groups_5008 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
jaccard_groups_1231 42.79 +- 18.19 10 0 1 0 0.13 +- 0.16 10 5

TIGR01484 (10/10) HAD hydrolase, family IIB
PF08282 (10/10) haloacid dehalogenase-like hydrolase
PF04149 (10/10) Domain of unknown function (DUF397)
PF00353 (10/10) RTX calcium-binding nonapeptide repeat (4 copies)
PF13560 (5/10) Helix-turn-helix domain
jaccard_groups_5003 519.33 +- 184.79 3 0 0 0 0.01 +- 0.00 3 6

PF08282 (3/3) haloacid dehalogenase-like hydrolase
PF01259 (3/3) SAICAR synthetase
PF00106 (3/3) short chain dehydrogenase
TIGR01484 (2/3) HAD hydrolase, family IIB
PF07690 (2/3) Major Facilitator Superfamily
PF00326 (2/3) Prolyl oligopeptidase family
jaccard_groups_1233 27.88 +- 3.22 2 0 0 0 0.20 +- 0.33 2 22

TIGR03444 (2/2) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
TIGR03442 (2/2) ergothioneine biosynthesis protein EgtC
TIGR03440 (2/2) ergothioneine biosynthesis protein EgtB
TIGR03438 (2/2) dimethylhistidine N-methyltransferase
PF13522 (2/2) Glutamine amidotransferase domain
PF12867 (2/2) DinB superfamily
PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
TIGR01891 (1/2) amidohydrolase
PF13515 (1/2) Fusaric acid resistance protein-like
PF13444 (1/2) Acetyltransferase (GNAT) domain
PF12802 (1/2) MarR family
PF11338 (1/2) Protein of unknown function (DUF3140)
PF05685 (1/2) Putative restriction endonuclease
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01553 (1/2) Acyltransferase
PF01546 (1/2) Peptidase family M20/M25/M40
PF01098 (1/2) Cell cycle protein
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
jaccard_groups_1232 109.99 +- 106.26 24 0 0 0 0.10 +- 0.13 24 6

PF14534 (22/24) Domain of unknown function (DUF4440)
PF08002 (22/24) Protein of unknown function (DUF1697)
PF05922 (22/24) Peptidase inhibitor I9
PF00082 (22/24) Subtilase family
PF00664 (14/24) ABC transporter transmembrane region
PF00005 (13/24) ABC transporter
jaccard_groups_5006 327.62 +- 23.17 3 0 0 0 0.01 +- 0.00 3 5

PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF07366 (3/3) SnoaL-like polyketide cyclase
PF05223 (3/3) NTF2-like N-terminal transpeptidase domain
PF00905 (3/3) Penicillin binding protein transpeptidase domain
jaccard_groups_5007 1030.83 +- 658.58 3 0 3 3 0.05 +- 0.19 3 8

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
PF04055 (3/3) Radical SAM superfamily
PF02896 (3/3) PEP-utilising enzyme, TIM barrel domain
PF01061 (3/3) ABC-2 type transporter
PF00391 (3/3) PEP-utilising enzyme, mobile domain
PF00160 (3/3) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
jaccard_groups_1237 65.64 +- 79.64 24 0 1 1 0.15 +- 0.18 24 10

TIGR01660 (24/24) nitrate reductase, beta subunit
TIGR01580 (24/24) nitrate reductase, alpha subunit
TIGR00684 (24/24) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (24/24) respiratory nitrate reductase, gamma subunit
PF14711 (24/24) Respiratory nitrate reductase beta C-terminal
PF13247 (24/24) 4Fe-4S dicluster domain
PF02665 (24/24) Nitrate reductase gamma subunit
PF02613 (24/24) Nitrate reductase delta subunit
PF01568 (24/24) Molydopterin dinucleotide binding domain
PF00384 (24/24) Molybdopterin oxidoreductase
jaccard_groups_618 38.91 +- 24.62 12 0 4 0 0.07 +- 0.07 12 4

PF08021 (12/12) Siderophore-interacting FAD-binding domain
PF04954 (12/12) Siderophore-interacting protein
PF17074 (8/12) Darcynin, domain of unknown function
PF03446 (8/12) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_104 121.55 +- 137.13 54 0 4 0 0.06 +- 0.08 54 2

PF13602 (53/54) Zinc-binding dehydrogenase
PF08240 (53/54) Alcohol dehydrogenase GroES-like domain
jaccard_groups_1306 222.22 +- 200.94 7 0 0 0 0.04 +- 0.04 7 2

PF14031 (7/7) Putative serine dehydratase domain
PF01168 (7/7) Alanine racemase, N-terminal domain
jaccard_groups_1301 10.22 +- 2.16 2 0 0 0 0.25 +- 0.36 2 7

PF13624 (2/2) SurA N-terminal domain
PF08924 (1/2) Domain of unknown function (DUF1906)
PF06737 (1/2) Transglycosylase-like domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF02384 (1/2) N-6 DNA Methylase
PF01476 (1/2) LysM domain
PF00069 (1/2) Protein kinase domain
jaccard_groups_103 98.01 +- 95.75 24 0 2 0 0.08 +- 0.12 24 1

PF00652 (24/24) Ricin-type beta-trefoil lectin domain
jaccard_groups_6543 237.95 +- 165.17 2 0 0 2 0.12 +- 0.26 2 11

PF18559 (2/2) Galactose-binding domain-like
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00535 (2/2) Glycosyl transferase family 2
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF02709 (1/2) N-terminal domain of galactosyltransferase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
jaccard_groups_3229 273.64 +- 353.82 3 0 0 2 0.13 +- 0.29 3 5

PF04972 (3/3) BON domain
PF00571 (3/3) CBS domain
PF00881 (2/3) Nitroreductase family
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
jaccard_groups_1495 240.02 +- 26.08 8 0 8 8 0.01 +- 0.03 8 7

TIGR03975 (8/8) ribosomal peptide maturation radical SAM protein 1
PF04055 (8/8) Radical SAM superfamily
PF02310 (8/8) B12 binding domain
PF08241 (5/8) Methyltransferase domain
PF13424 (4/8) Tetratricopeptide repeat
PF03704 (4/8) Bacterial transcriptional activator domain
PF00931 (4/8) NB-ARC domain
jaccard_groups_1497 156.24 +- 87.09 39 0 6 0 0.13 +- 0.15 39 16

PF13378 (38/39) Enolase C-terminal domain-like
PF02746 (38/39) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF13561 (37/39) Enoyl-(Acyl carrier protein) reductase
PF07729 (37/39) FCD domain
PF00392 (37/39) Bacterial regulatory proteins, gntR family
PF13407 (36/39) Periplasmic binding protein domain
PF08240 (36/39) Alcohol dehydrogenase GroES-like domain
PF02653 (36/39) Branched-chain amino acid transport system / permease component
PF00107 (36/39) Zinc-binding dehydrogenase
PF00005 (36/39) ABC transporter
PF01081 (34/39) KDPG and KHG aldolase
PF00294 (34/39) pfkB family carbohydrate kinase
TIGR01182 (33/39) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF05025 (31/39) RbsD / FucU transport protein family
PF00248 (31/39) Aldo/keto reductase family
PF04909 (28/39) Amidohydrolase
jaccard_groups_1496 94.93 +- 8.27 2 0 0 0 0.03 +- 0.02 2 7

PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
TIGR00377 (1/2) anti-anti-sigma factor
PF01740 (1/2) STAS domain
PF00293 (1/2) NUDIX domain
jaccard_groups_1491 704.75 +- 578.21 34 0 34 0 0.02 +- 0.02 34 8

PF00550 (34/34) Phosphopantetheine attachment site
PF00664 (33/34) ABC transporter transmembrane region
PF00005 (33/34) ABC transporter
PF00668 (32/34) Condensation domain
PF00501 (32/34) AMP-binding enzyme
PF16861 (20/34) Carbamoyltransferase C-terminus
PF02543 (20/34) Carbamoyltransferase N-terminus
PF13193 (17/34) AMP-binding enzyme C-terminal domain
jaccard_groups_1943 69.82 +- 128.86 13 0 0 13 0.12 +- 0.30 13 7

PF03704 (13/13) Bacterial transcriptional activator domain
PF02687 (13/13) FtsX-like permease family
PF00486 (13/13) Transcriptional regulatory protein, C terminal
PF00005 (13/13) ABC transporter
PF14518 (12/13) Iron-containing redox enzyme
PF04055 (12/13) Radical SAM superfamily
PF12704 (11/13) MacB-like periplasmic core domain
jaccard_groups_4447 96.51 +- 36.71 4 0 0 0 0.15 +- 0.14 4 15

TIGR01392 (4/4) homoserine O-acetyltransferase
TIGR01326 (4/4) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF18029 (4/4) Glyoxalase-like domain
PF08007 (4/4) Cupin superfamily protein
PF06999 (4/4) Sucrase/ferredoxin-like
PF03404 (4/4) Mo-co oxidoreductase dimerisation domain
PF01184 (4/4) GPR1/FUN34/yaaH family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00561 (4/4) alpha/beta hydrolase fold
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
TIGR01409 (3/4) Tat (twin-arginine translocation) pathway signal sequence
TIGR02980 (2/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04539 (2/4) Sigma-70 region 3
jaccard_groups_1945 67.55 +- 34.41 15 0 1 0 0.17 +- 0.13 15 9

PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF13646 (14/15) HEAT repeats
PF12838 (14/15) 4Fe-4S dicluster domain
PF09084 (14/15) NMT1/THI5 like
PF07702 (14/15) UTRA domain
PF02910 (14/15) Fumarate reductase flavoprotein C-term
PF00890 (14/15) FAD binding domain
PF00392 (14/15) Bacterial regulatory proteins, gntR family
PF00005 (14/15) ABC transporter
jaccard_groups_4442 25.61 +- 10.50 2 0 1 0 0.11 +- 0.19 2 4

PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00561 (2/2) alpha/beta hydrolase fold
PF13653 (1/2) Glycerophosphoryl diester phosphodiesterase family
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
jaccard_groups_1781 32.14 +- 16.31 3 0 0 0 0.09 +- 0.13 3 3

PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1785 208.96 +- 152.37 20 0 0 0 0.03 +- 0.06 20 3

PF00877 (20/20) NlpC/P60 family
PF01145 (15/20) SPFH domain / Band 7 family
PF00196 (15/20) Bacterial regulatory proteins, luxR family
jaccard_groups_4049 909.95 +- 631.92 3 0 1 0 0.07 +- 0.19 3 15

PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00072 (3/3) Response regulator receiver domain
TIGR02960 (2/3) RNA polymerase sigma-70 factor, TIGR02960 family
PF14330 (2/3) Domain of unknown function (DUF4387)
PF08281 (2/3) Sigma-70, region 4
PF07287 (2/3) Acyclic terpene utilisation family protein AtuA
PF04542 (2/3) Sigma-70 region 2
PF03176 (2/3) MMPL family
PF01872 (2/3) RibD C-terminal domain
jaccard_groups_1546 304.58 +- 17.92 2 0 0 0 0.01 +- 0.01 2 12

PF13814 (2/2) Replication-relaxation
PF12696 (2/2) TraM recognition site of TraD and TraG
PF12666 (2/2) PrgI family protein
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF01464 (2/2) Transglycosylase SLT domain
PF00877 (2/2) NlpC/P60 family
TIGR03930 (1/2) WXG100 family type VII secretion target
PF12846 (1/2) AAA-like domain
PF10824 (1/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (1/2) Proteins of 100 residues with WXG
PF01935 (1/2) Helicase HerA, central domain
PF00005 (1/2) ABC transporter
jaccard_groups_1544 78.11 +- 99.23 14 0 5 0 0.12 +- 0.17 14 5

PF07690 (14/14) Major Facilitator Superfamily
PF00067 (11/14) Cytochrome P450
PF13561 (10/14) Enoyl-(Acyl carrier protein) reductase
PF00440 (10/14) Bacterial regulatory proteins, tetR family
PF08044 (7/14) Domain of unknown function (DUF1707)
jaccard_groups_1014 98.07 +- 134.96 4 0 0 0 0.13 +- 0.31 4 10

TIGR00360 (4/4) ComEC/Rec2-related protein
PF12840 (4/4) Helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF03772 (4/4) Competence protein
PF00797 (4/4) N-acetyltransferase
PF00753 (4/4) Metallo-beta-lactamase superfamily
TIGR00762 (3/4) EDD domain protein, DegV family
PF02645 (3/4) Uncharacterised protein, DegV family COG1307
PF12836 (2/4) Helix-hairpin-helix motif
PF10531 (2/4) SLBB domain
jaccard_groups_1017 23.46 +- 1.67 2 0 1 0 0.24 +- 0.31 2 10

TIGR03709 (2/2) polyphosphate:nucleotide phosphotransferase, PPK2 family
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF01522 (2/2) Polysaccharide deacetylase
PF01266 (2/2) FAD dependent oxidoreductase
PF01145 (2/2) SPFH domain / Band 7 family
PF00484 (2/2) Carbonic anhydrase
PF00355 (2/2) Rieske [2Fe-2S] domain
TIGR00481 (1/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF01161 (1/2) Phosphatidylethanolamine-binding protein
PF00916 (1/2) Sulfate permease family
jaccard_groups_1540 60.44 +- 77.41 8 0 0 0 0.10 +- 0.11 8 5

TIGR04012 (8/8) poly-gamma-glutamate synthase PgsB
PF14102 (8/8) Capsule biosynthesis CapC
PF08245 (8/8) Mur ligase middle domain
PF00877 (8/8) NlpC/P60 family
PF00672 (8/8) HAMP domain
jaccard_groups_4041 51.44 +- 24.07 2 0 0 0 0.11 +- 0.16 2 6

PF01042 (2/2) Endoribonuclease L-PSP
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00561 (2/2) alpha/beta hydrolase fold
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00037 (1/2) 4Fe-4S binding domain
jaccard_groups_4042 604.20 +- 273.30 2 0 1 0 0.02 +- 0.01 2 11

PF13377 (2/2) Periplasmic binding protein-like domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02018 (1/2) Carbohydrate binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_3949 22.50 +- 3.18 5 0 0 0 0.18 +- 0.17 5 5

PF13564 (5/5) DoxX-like family
PF11139 (5/5) Sap, sulfolipid-1-addressing protein
PF07690 (5/5) Major Facilitator Superfamily
PF04029 (5/5) 2-phosphosulpholactate phosphatase
PF01494 (5/5) FAD binding domain
jaccard_groups_3940 1661.04 +- 262.74 4 0 2 4 0.01 +- 0.01 4 11

TIGR00702 (4/4) YcaO-type kinase domain
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF08007 (4/4) Cupin superfamily protein
PF07812 (4/4) TfuA-like protein
PF07690 (4/4) Major Facilitator Superfamily
PF05193 (4/4) Peptidase M16 inactive domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (4/4) Aminoglycoside 3-N-acetyltransferase
PF00675 (4/4) Insulinase (Peptidase family M16)
PF00326 (4/4) Prolyl oligopeptidase family
PF13349 (2/4) Putative adhesin
jaccard_groups_3947 299.56 +- 173.55 5 0 0 0 0.05 +- 0.06 5 7

PF14592 (5/5) Chondroitinase B
PF13472 (5/5) GDSL-like Lipase/Acylhydrolase family
PF01120 (5/5) Alpha-L-fucosidase
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF13416 (4/5) Bacterial extracellular solute-binding protein
PF01261 (4/5) Xylose isomerase-like TIM barrel
TIGR03804 (3/5) parallel beta-helix repeat
jaccard_groups_3946 147.72 +- 51.98 5 0 0 0 0.04 +- 0.04 5 8

PF07690 (5/5) Major Facilitator Superfamily
PF01596 (5/5) O-methyltransferase
PF01402 (5/5) Ribbon-helix-helix protein, copG family
PF00970 (5/5) Oxidoreductase FAD-binding domain
PF00175 (5/5) Oxidoreductase NAD-binding domain
PF00072 (5/5) Response regulator receiver domain
TIGR00027 (3/5) methyltransferase, TIGR00027 family
PF04072 (3/5) Leucine carboxyl methyltransferase
jaccard_groups_1165 85.80 +- 24.16 4 0 0 0 0.04 +- 0.06 4 6

TIGR00575 (4/4) DNA ligase, NAD-dependent
PF12826 (4/4) Helix-hairpin-helix motif
PF03120 (4/4) NAD-dependent DNA ligase OB-fold domain
PF01653 (4/4) NAD-dependent DNA ligase adenylation domain
PF00533 (4/4) BRCA1 C Terminus (BRCT) domain
PF14520 (2/4) Helix-hairpin-helix domain
jaccard_groups_1164 83.95 +- 59.76 52 0 3 0 0.07 +- 0.05 52 4

PF13738 (52/52) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (52/52) FMN-dependent dehydrogenase
PF00999 (52/52) Sodium/hydrogen exchanger family
PF00067 (52/52) Cytochrome P450
jaccard_groups_1160 407.43 +- 379.53 60 0 58 0 0.09 +- 0.14 60 22

PF07690 (60/60) Major Facilitator Superfamily
PF02668 (60/60) Taurine catabolism dioxygenase TauD, TfdA family
PF00550 (60/60) Phosphopantetheine attachment site
PF13193 (58/60) AMP-binding enzyme C-terminal domain
PF10862 (58/60) FcoT-like thioesterase domain
PF00501 (58/60) AMP-binding enzyme
PF00668 (57/60) Condensation domain
PF07993 (56/60) Male sterility protein
TIGR01746 (55/60) thioester reductase domain
TIGR01733 (55/60) amino acid adenylation domain
PF05118 (54/60) Aspartyl/Asparaginyl beta-hydroxylase
PF01497 (53/60) Periplasmic binding protein
PF01032 (53/60) FecCD transport family
PF00005 (53/60) ABC transporter
PF08545 (50/60) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (50/60) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
TIGR00747 (49/60) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF04314 (45/60) Copper chaperone PCu(A)C
TIGR01525 (44/60) heavy metal translocating P-type ATPase
PF00702 (44/60) haloacid dehalogenase-like hydrolase
PF00403 (44/60) Heavy-metal-associated domain
PF00122 (44/60) E1-E2 ATPase
jaccard_groups_1763 101.39 +- 51.59 7 0 1 0 0.09 +- 0.13 7 12

TIGR03026 (7/7) nucleotide sugar dehydrogenase
TIGR00696 (7/7) glycosyltransferase, WecB/TagA/CpsF family
PF14602 (7/7) Hexapeptide repeat of succinyl-transferase
PF13440 (7/7) Polysaccharide biosynthesis protein
PF03808 (7/7) Glycosyl transferase WecB/TagA/CpsF family
PF03721 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02350 (7/7) UDP-N-acetylglucosamine 2-epimerase
PF00984 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (7/7) Glycosyl transferase family 2
PF00132 (7/7) Bacterial transferase hexapeptide (six repeats)
TIGR00236 (6/7) UDP-N-acetylglucosamine 2-epimerase
jaccard_groups_198 23.11 +- 20.98 4 0 1 0 0.15 +- 0.25 4 3

PF00704 (4/4) Glycosyl hydrolases family 18
PF06483 (2/4) Chitinase C
PF00652 (2/4) Ricin-type beta-trefoil lectin domain
jaccard_groups_199 236.20 +- 209.18 9 0 0 0 0.02 +- 0.06 9 1

PF00400 (9/9) WD domain, G-beta repeat
jaccard_groups_197 127.67 +- 145.83 22 0 0 0 0.09 +- 0.15 22 4

PF13280 (22/22) WYL domain
PF08279 (20/22) HTH domain
PF13649 (14/22) Methyltransferase domain
PF00300 (14/22) Histidine phosphatase superfamily (branch 1)
jaccard_groups_194 15.19 +- 3.88 6 0 0 0 0.18 +- 0.23 6 4

PF08220 (6/6) DeoR-like helix-turn-helix domain
PF00455 (6/6) DeoR C terminal sensor domain
PF01116 (4/6) Fructose-bisphosphate aldolase class-II
PF01380 (3/6) SIS domain
jaccard_groups_222 577.76 +- 709.61 324 0 12 12 0.08 +- 0.13 324 5

PF07811 (322/324) TadE-like protein
PF00437 (322/324) Type II/IV secretion system protein
PF00482 (319/324) Type II secretion system (T2SS), protein F
PF13400 (239/324) Putative Flp pilus-assembly TadE/G-like
PF01476 (163/324) LysM domain
jaccard_groups_223 68.72 +- 80.87 17 0 17 0 0.13 +- 0.25 17 3

PF06236 (17/17) Tyrosinase co-factor MelC1
PF00264 (17/17) Common central domain of tyrosinase
PF03777 (11/17) ChpA-C
jaccard_groups_224 39.00 +- 0.00 2 0 0 0 0.05 +- 0.03 2 2

PF05532 (2/2) CsbD-like
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_226 125.15 +- 97.07 3 0 0 0 0.04 +- 0.05 3 1

PF00795 (3/3) Carbon-nitrogen hydrolase
jaccard_groups_228 55.71 +- 30.95 2 0 0 0 0.05 +- 0.09 2 2

PF07876 (2/2) Stress responsive A/B Barrel Domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
jaccard_groups_4539 1832.43 +- 932.16 3 0 0 3 0.02 +- 0.05 3 18

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01522 (3/3) Polysaccharide deacetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (3/3) Asparagine synthase
PF00550 (3/3) Phosphopantetheine attachment site
PF00535 (3/3) Glycosyl transferase family 2
PF00501 (3/3) AMP-binding enzyme
PF00155 (3/3) Aminotransferase class I and II
TIGR04364 (2/3) methyltransferase, FxLD system
PF08242 (2/3) Methyltransferase domain
PF01135 (2/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/3) NUDIX domain
jaccard_groups_4538 383.97 +- 301.74 3 0 3 0 0.13 +- 0.27 3 28

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00155 (3/3) Aminotransferase class I and II
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
TIGR00223 (2/3) aspartate 1-decarboxylase
PF13847 (2/3) Methyltransferase domain
PF13535 (2/3) ATP-grasp domain
PF13450 (2/3) NAD(P)-binding Rossmann-like domain
PF13358 (2/3) DDE superfamily endonuclease
PF03621 (2/3) MbtH-like protein
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF02729 (2/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02261 (2/3) Aspartate decarboxylase
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00185 (2/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
jaccard_groups_4997 388.67 +- 90.04 3 0 0 3 0.01 +- 0.01 3 8

TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF13537 (3/3) Glutamine amidotransferase domain
PF11794 (3/3) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08242 (3/3) Methyltransferase domain
PF03241 (3/3) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (3/3) Flavin reductase like domain
PF00733 (3/3) Asparagine synthase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
jaccard_groups_4223 195.78 +- 132.58 2 0 2 0 0.07 +- 0.23 2 20

PF07690 (2/2) Major Facilitator Superfamily
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (2/2) Biotin carboxylase C-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00364 (2/2) Biotin-requiring enzyme
PF00289 (2/2) Biotin carboxylase, N-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF06094 (1/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF01522 (1/2) Polysaccharide deacetylase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_4991 10.00 +- 1.15 3 0 0 0 0.20 +- 0.20 3 4

PF16113 (3/3) Enoyl-CoA hydratase/isomerase
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_4226 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
jaccard_groups_3896 693.88 +- 690.26 5 0 0 0 0.07 +- 0.18 5 21

TIGR01928 (5/5) o-succinylbenzoate synthase
TIGR01727 (5/5) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF13378 (5/5) Enolase C-terminal domain-like
PF08352 (5/5) Oligopeptide/dipeptide transporter, C-terminal region
PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01546 (5/5) Peptidase family M20/M25/M40
PF01380 (5/5) SIS domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00496 (5/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (5/5) ABC transporter
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF12831 (4/5) FAD dependent oxidoreductase
PF07883 (4/5) Cupin domain
PF07690 (4/5) Major Facilitator Superfamily
PF02515 (4/5) CoA-transferase family III
PF01381 (4/5) Helix-turn-helix
PF00701 (4/5) Dihydrodipicolinate synthetase family
PF00378 (4/5) Enoyl-CoA hydratase/isomerase
PF00171 (4/5) Aldehyde dehydrogenase family
jaccard_groups_3892 58.54 +- 52.32 5 0 0 0 0.11 +- 0.08 5 5

PF05141 (5/5) Pyoverdine/dityrosine biosynthesis protein
PF00067 (5/5) Cytochrome P450
PF12697 (4/5) Alpha/beta hydrolase family
PF12833 (3/5) Helix-turn-helix domain
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_4999 51.28 +- 32.85 2 0 1 0 0.10 +- 0.16 2 4

PF09992 (2/2) Phosphodiester glycosidase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00480 (2/2) ROK family
PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_1401 71.31 +- 110.41 9 0 2 0 0.13 +- 0.18 9 2

PF00440 (9/9) Bacterial regulatory proteins, tetR family
PF00248 (9/9) Aldo/keto reductase family
jaccard_groups_6119 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family
jaccard_groups_6115 26.34 +- 1.11 2 0 2 0 0.15 +- 0.22 2 14

TIGR03086 (2/2) TIGR03086 family protein
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12740 (2/2) Chlorophyllase enzyme
PF12697 (2/2) Alpha/beta hydrolase family
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11611 (2/2) Domain of unknown function (DUF4352)
PF07690 (2/2) Major Facilitator Superfamily
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF00741 (2/2) Gas vesicle protein
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00561 (2/2) alpha/beta hydrolase fold
jaccard_groups_3412 199.53 +- 41.27 4 0 4 0 0.02 +- 0.01 4 4

PF11468 (4/4) Aromatic prenyltransferase Orf2
PF04672 (4/4) S-adenosyl methyltransferase
PF03284 (4/4) Phenazine biosynthesis protein A/B
PF01494 (4/4) FAD binding domain
jaccard_groups_6117 185.73 +- 13.00 2 0 2 0 0.17 +- 0.26 2 19

PF13577 (2/2) SnoaL-like domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00891 (2/2) O-methyltransferase domain
PF00581 (2/2) Rhodanese-like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF16864 (1/2) Dimerisation domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF12697 (1/2) Alpha/beta hydrolase family
jaccard_groups_3410 18.55 +- 5.04 6 0 0 0 0.19 +- 0.36 6 9

TIGR00465 (6/6) ketol-acid reductoisomerase
PF12902 (6/6) Ferritin-like
PF08281 (6/6) Sigma-70, region 4
PF07991 (6/6) Acetohydroxy acid isomeroreductase, NADPH-binding domain
PF04542 (6/6) Sigma-70 region 2
PF01450 (6/6) Acetohydroxy acid isomeroreductase, catalytic domain
PF00903 (6/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF13191 (3/6) AAA ATPase domain
jaccard_groups_3417 325.00 +- 195.00 2 0 2 0 0.03 +- 0.04 2 11

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08241 (2/2) Methyltransferase domain
PF07993 (2/2) Male sterility protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00106 (2/2) short chain dehydrogenase
PF07690 (1/2) Major Facilitator Superfamily
jaccard_groups_6113 39.10 +- 4.23 2 0 0 0 0.13 +- 0.22 2 14

TIGR01132 (2/2) phosphoglucomutase, alpha-D-glucose phosphate-specific
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12802 (2/2) MarR family
PF08448 (2/2) PAS fold
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01590 (2/2) GAF domain
PF00857 (2/2) Isochorismatase family
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
TIGR00229 (1/2) PAS domain S-box protein
jaccard_groups_3414 197.53 +- 57.43 7 0 0 0 0.04 +- 0.05 7 10

PF09339 (7/7) IclR helix-turn-helix domain
PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01614 (7/7) Bacterial transcriptional regulator
PF01425 (7/7) Amidase
PF00795 (7/7) Carbon-nitrogen hydrolase
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
PF02866 (6/7) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02775 (6/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00171 (6/7) Aldehyde dehydrogenase family
PF00056 (6/7) lactate/malate dehydrogenase, NAD binding domain
jaccard_groups_3306 266.41 +- 230.78 4 0 0 0 0.05 +- 0.11 4 5

PF12802 (4/4) MarR family
PF00561 (4/4) alpha/beta hydrolase fold
TIGR03620 (3/4) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF07859 (3/4) alpha/beta hydrolase fold
PF06441 (3/4) Epoxide hydrolase N terminus
jaccard_groups_3300 57.50 +- 6.05 4 0 0 4 0.11 +- 0.12 4 6

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF13565 (4/4) Homeodomain-like domain
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF02954 (4/4) Bacterial regulatory protein, Fis family
PF01590 (4/4) GAF domain
PF00733 (4/4) Asparagine synthase
jaccard_groups_6200 212.46 +- 24.04 2 0 1 0 0.05 +- 0.04 2 14

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF04072 (2/2) Leucine carboxyl methyltransferase
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF18604 (1/2) Pre ATP-grasp domain
PF00975 (1/2) Thioesterase domain
jaccard_groups_6202 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_3309 201.38 +- 129.32 7 0 3 0 0.07 +- 0.16 7 6

TIGR00711 (7/7) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (7/7) Major Facilitator Superfamily
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
PF03777 (4/7) ChpA-C
jaccard_groups_535 136.90 +- 121.10 2 0 0 0 0.08 +- 0.11 2 3

PF01814 (2/2) Hemerythrin HHE cation binding domain
PF06305 (1/2) Lipopolysaccharide assembly protein A domain
PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_537 21.82 +- 12.34 26 0 1 0 0.16 +- 0.25 26 3

PF13641 (26/26) Glycosyltransferase like family 2
PF01757 (26/26) Acyltransferase family
PF01522 (26/26) Polysaccharide deacetylase
jaccard_groups_3091 913.02 +- 827.87 8 0 8 0 0.04 +- 0.05 8 26

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (8/8) amino acid adenylation domain
TIGR00976 (8/8) hydrolase CocE/NonD family protein
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF13187 (8/8) 4Fe-4S dicluster domain
PF08659 (8/8) KR domain
PF08545 (8/8) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (8/8) Major Facilitator Superfamily
PF04432 (8/8) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (8/8) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF02737 (8/8) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (8/8) FMN-dependent dehydrogenase
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00296 (8/8) Luciferase-like monooxygenase
PF00275 (8/8) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (8/8) Aminotransferase class-III
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF07228 (4/8) Stage II sporulation protein E (SpoIIE)
jaccard_groups_904 266.50 +- 203.60 3 0 3 0 0.04 +- 0.08 3 1

PF00668 (3/3) Condensation domain
jaccard_groups_538 411.87 +- 425.79 68 0 16 5 0.07 +- 0.11 68 5

PF00528 (68/68) Binding-protein-dependent transport system inner membrane component
PF00005 (67/68) ABC transporter
PF08402 (60/68) TOBE domain
PF13416 (59/68) Bacterial extracellular solute-binding protein
PF00171 (46/68) Aldehyde dehydrogenase family
jaccard_groups_453 62.55 +- 5.10 3 0 2 0 0.22 +- 0.26 3 16

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (3/3) FCD domain
PF05544 (3/3) Proline racemase
PF04324 (3/3) BFD-like [2Fe-2S] binding domain
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
jaccard_groups_451 102.03 +- 94.78 9 0 1 1 0.07 +- 0.14 9 3

PF07732 (9/9) Multicopper oxidase
PF07731 (9/9) Multicopper oxidase
PF00394 (6/9) Multicopper oxidase
jaccard_groups_450 36.51 +- 38.43 3 0 0 0 0.17 +- 0.31 3 3

TIGR00223 (3/3) aspartate 1-decarboxylase
PF02261 (3/3) Aspartate decarboxylase
PF14542 (2/3) GCN5-related N-acetyl-transferase
jaccard_groups_454 56.55 +- 21.32 21 0 0 0 0.21 +- 0.30 21 10

PF12911 (21/21) N-terminal TM domain of oligopeptide transport permease C
PF11997 (21/21) Domain of unknown function (DUF3492)
PF08352 (21/21) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (21/21) Binding-protein-dependent transport system inner membrane component
PF00496 (21/21) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (21/21) ABC transporter
PF13692 (20/21) Glycosyl transferases group 1
PF11350 (19/21) Protein of unknown function (DUF3152)
PF01370 (15/21) NAD dependent epimerase/dehydratase family
PF12138 (14/21) Spherulation-specific family 4
jaccard_groups_3525 246.07 +- 111.87 6 0 4 0 0.02 +- 0.01 6 3

PF06912 (6/6) Protein of unknown function (DUF1275)
PF03928 (6/6) Haem-degrading
PF00171 (6/6) Aldehyde dehydrogenase family
jaccard_groups_3174 266.39 +- 170.78 4 0 0 0 0.08 +- 0.23 4 6

TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01141 (4/4) histidinol-phosphate transaminase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00155 (4/4) Aminotransferase class I and II
PF01613 (3/4) Flavin reductase like domain
jaccard_groups_2143 483.98 +- 209.35 2 0 2 1 0.06 +- 0.11 2 17

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03704 (2/2) Bacterial transcriptional activator domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00440 (2/2) Bacterial regulatory proteins, tetR family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17227 (1/2) Family of unknown function (DUF5302)
PF13822 (1/2) Acyl-CoA carboxylase epsilon subunit
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF00698 (1/2) Acyl transferase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_2140 152.40 +- 88.39 4 0 0 0 0.03 +- 0.07 4 5

PF07853 (4/4) Protein of unknown function (DUF1648)
PF13411 (2/4) MerR HTH family regulatory protein
PF04264 (2/4) YceI-like domain
PF01909 (2/4) Nucleotidyltransferase domain
PF00392 (2/4) Bacterial regulatory proteins, gntR family
jaccard_groups_2147 114.26 +- 40.54 2 0 0 0 0.02 +- 0.02 2 3

PF06172 (2/2) Cupin superfamily (DUF985)
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF13564 (1/2) DoxX-like family
jaccard_groups_2145 124.17 +- 101.88 15 0 0 0 0.18 +- 0.26 15 18

PF00583 (15/15) Acetyltransferase (GNAT) family
PF01756 (14/15) Acyl-CoA oxidase
PF11941 (13/15) Domain of unknown function (DUF3459)
PF01497 (13/15) Periplasmic binding protein
PF00128 (13/15) Alpha amylase, catalytic domain
PF07705 (12/15) CARDB
PF00754 (12/15) F5/8 type C domain
PF00294 (12/15) pfkB family carbohydrate kinase
TIGR00105 (11/15) ribosomal protein bL31
PF02770 (11/15) Acyl-CoA dehydrogenase, middle domain
PF01197 (11/15) Ribosomal protein L31
TIGR00765 (10/15) YihY family inner membrane protein
PF05922 (10/15) Peptidase inhibitor I9
PF03631 (10/15) Virulence factor BrkB
PF01032 (10/15) FecCD transport family
PF00082 (10/15) Subtilase family
PF00005 (10/15) ABC transporter
PF08028 (8/15) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_2925 17.84 +- 8.27 3 0 0 0 0.12 +- 0.15 3 3

PF13515 (3/3) Fusaric acid resistance protein-like
PF01979 (3/3) Amidohydrolase family
PF05988 (2/3) Bacterial protein of unknown function (DUF899)
jaccard_groups_2148 178.59 +- 147.68 3 0 0 0 0.04 +- 0.04 3 3

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (3/3) Cytochrome P450
PF03745 (2/3) Domain of unknown function (DUF309)
jaccard_groups_2149 91.97 +- 23.01 8 0 4 0 0.11 +- 0.16 8 13

PF17645 (8/8) Arylmalonate decarboxylase
PF12697 (8/8) Alpha/beta hydrolase family
PF06240 (8/8) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (8/8) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (8/8) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (8/8) [2Fe-2S] binding domain
PF01494 (8/8) FAD binding domain
PF01315 (8/8) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (8/8) MarR family
PF00941 (8/8) FAD binding domain in molybdopterin dehydrogenase
PF00857 (8/8) Isochorismatase family
PF00083 (8/8) Sugar (and other) transporter
PF00111 (7/8) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_2922 30.42 +- 7.21 6 0 0 0 0.16 +- 0.09 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01494 (6/6) FAD binding domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF04131 (5/6) Putative N-acetylmannosamine-6-phosphate epimerase
PF00701 (5/6) Dihydrodipicolinate synthetase family
PF00480 (5/6) ROK family
jaccard_groups_3172 161.77 +- 52.50 8 0 0 0 0.07 +- 0.08 8 6

PF09362 (8/8) Domain of unknown function (DUF1996)
PF03713 (8/8) Domain of unknown function (DUF305)
PF02861 (8/8) Clp amino terminal domain, pathogenicity island component
PF01061 (8/8) ABC-2 type transporter
PF00005 (8/8) ABC transporter
PF00754 (6/8) F5/8 type C domain
jaccard_groups_984 173.49 +- 170.81 56 0 30 49 0.05 +- 0.06 56 3

PF07690 (55/56) Major Facilitator Superfamily
PF13649 (50/56) Methyltransferase domain
PF04055 (49/56) Radical SAM superfamily
jaccard_groups_3631 237.69 +- 314.93 5 0 5 0 0.10 +- 0.26 5 18

TIGR00171 (5/5) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (5/5) 3-isopropylmalate dehydratase, large subunit
PF00694 (5/5) Aconitase C-terminal domain
PF00682 (5/5) HMGL-like
PF00330 (5/5) Aconitase family (aconitate hydratase)
PF00180 (5/5) Isocitrate/isopropylmalate dehydrogenase
PF00155 (5/5) Aminotransferase class I and II
TIGR00169 (4/5) 3-isopropylmalate dehydrogenase
PF11806 (4/5) Domain of unknown function (DUF3327)
PF03621 (4/5) MbtH-like protein
PF00756 (4/5) Putative esterase
TIGR01733 (3/5) amino acid adenylation domain
TIGR01720 (3/5) non-ribosomal peptide synthase domain TIGR01720
PF13193 (3/5) AMP-binding enzyme C-terminal domain
PF08242 (3/5) Methyltransferase domain
PF00668 (3/5) Condensation domain
PF00550 (3/5) Phosphopantetheine attachment site
PF00501 (3/5) AMP-binding enzyme
jaccard_groups_3630 666.10 +- 448.37 3 0 0 0 0.02 +- 0.03 3 6

PF16875 (3/3) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (3/3) Glycosyl hydrolase family 36 C-terminal domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF02065 (3/3) Melibiase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF14498 (2/3) Glycosyl hydrolase family 65, N-terminal domain
jaccard_groups_3636 205.00 +- 103.34 5 0 4 0 0.04 +- 0.02 5 16

TIGR03947 (5/5) capreomycidine synthase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02585 (5/5) GlcNAc-PI de-N-acetylase
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (5/5) Glycosyl transferase family 2
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
TIGR03946 (4/5) arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependent
TIGR01733 (4/5) amino acid adenylation domain
PF00550 (4/5) Phosphopantetheine attachment site
PF01370 (3/5) NAD dependent epimerase/dehydratase family
PF00583 (3/5) Acetyltransferase (GNAT) family
jaccard_groups_983 204.38 +- 185.86 11 0 2 0 0.04 +- 0.08 11 5

PF18565 (11/11) Glycoside hydrolase family 2 C-terminal domain 5
PF02837 (11/11) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (11/11) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (11/11) Glycosyl hydrolases family 2
PF16355 (10/11) Domain of unknown function (DUF4982)
jaccard_groups_5491 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
jaccard_groups_2218 248.25 +- 275.23 14 0 0 0 0.11 +- 0.19 14 11

PF03033 (14/14) Glycosyltransferase family 28 N-terminal domain
PF01551 (14/14) Peptidase family M23
PF00392 (14/14) Bacterial regulatory proteins, gntR family
PF00005 (14/14) ABC transporter
PF12679 (13/14) ABC-2 family transporter protein
PF13411 (10/14) MerR HTH family regulatory protein
PF07739 (10/14) TipAS antibiotic-recognition domain
TIGR01764 (7/14) DNA binding domain, excisionase family
PF13245 (7/14) AAA domain
PF12728 (7/14) Helix-turn-helix domain
PF12697 (7/14) Alpha/beta hydrolase family
jaccard_groups_5492 42.56 +- 10.58 2 0 2 0 0.18 +- 0.36 2 13

TIGR01123 (2/2) branched-chain amino acid aminotransferase
TIGR00977 (2/2) citramalate synthase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08502 (2/2) LeuA allosteric (dimerisation) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01063 (2/2) Amino-transferase class IV
PF00975 (2/2) Thioesterase domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF13581 (1/2) Histidine kinase-like ATPase domain
jaccard_groups_5496 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
jaccard_groups_2213 239.20 +- 125.72 6 0 6 0 0.05 +- 0.06 6 15

TIGR00747 (6/6) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03364 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF00550 (6/6) Phosphopantetheine attachment site
PF00202 (6/6) Aminotransferase class-III
PF00171 (6/6) Aldehyde dehydrogenase family
TIGR00414 (4/6) serine--tRNA ligase
PF00587 (4/6) tRNA synthetase class II core domain (G, H, P, S and T)
PF03972 (3/6) MmgE/PrpD family
PF02801 (3/6) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/6) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (3/6) Flavin reductase like domain
PF00781 (3/6) Diacylglycerol kinase catalytic domain
PF00109 (3/6) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_2214 17.23 +- 11.82 3 0 0 0 0.19 +- 0.22 3 5

PF13641 (3/3) Glycosyltransferase like family 2
PF09118 (3/3) Domain of unknown function (DUF1929)
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2
PF13231 (2/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
jaccard_groups_2850 68.45 +- 86.76 6 0 2 0 0.10 +- 0.15 6 5

TIGR02601 (6/6) autotransporter-associated beta strand repeat
PF12951 (6/6) Passenger-associated-transport-repeat
PF01569 (6/6) PAP2 superfamily
PF02366 (4/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF01418 (3/6) Helix-turn-helix domain, rpiR family
jaccard_groups_2851 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
jaccard_groups_6373 24.72 +- 1.08 2 0 0 0 0.16 +- 0.23 2 9

TIGR01031 (2/2) ribosomal protein bL32
PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (2/2) Ribosomal L32p protein family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
jaccard_groups_5819 1066.24 +- 281.26 2 0 2 1 0.04 +- 0.07 2 17

PF16347 (2/2) Domain of unknown function (DUF4976)
PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01301 (2/2) Glycosyl hydrolases family 35
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF00664 (1/2) ABC transporter transmembrane region
PF00296 (1/2) Luciferase-like monooxygenase
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
jaccard_groups_6374 50.74 +- 14.21 2 0 0 0 0.12 +- 0.12 2 6

PF08751 (2/2) TrwC relaxase
PF08007 (2/2) Cupin superfamily protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00248 (2/2) Aldo/keto reductase family
PF01545 (1/2) Cation efflux family
jaccard_groups_2321 294.37 +- 149.66 7 0 0 2 0.09 +- 0.20 7 3

PF07690 (7/7) Major Facilitator Superfamily
PF01425 (7/7) Amidase
PF01244 (5/7) Membrane dipeptidase (Peptidase family M19)
jaccard_groups_2859 36.79 +- 28.21 2 0 2 0 0.13 +- 0.15 2 5

PF01613 (2/2) Flavin reductase like domain
PF12708 (1/2) Pectate lyase superfamily protein
PF04820 (1/2) Tryptophan halogenase
PF01494 (1/2) FAD binding domain
PF00999 (1/2) Sodium/hydrogen exchanger family
jaccard_groups_5816 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02223 (2/2) Thymidylate kinase
PF01503 (2/2) Phosphoribosyl-ATP pyrophosphohydrolase
jaccard_groups_2459 172.52 +- 97.26 6 0 3 0 0.10 +- 0.26 6 2

PF06368 (6/6) Methylaspartate mutase E chain (MutE)
PF02310 (6/6) B12 binding domain
jaccard_groups_2454 142.81 +- 137.21 5 0 0 5 0.04 +- 0.05 5 3

PF04055 (5/5) Radical SAM superfamily
PF01928 (5/5) CYTH domain
PF13581 (3/5) Histidine kinase-like ATPase domain
jaccard_groups_2451 58.42 +- 11.22 2 0 0 0 0.07 +- 0.08 2 8

TIGR00078 (2/2) nicotinate-nucleotide diphosphorylase (carboxylating)
PF07045 (2/2) Domain of unknown function (DUF1330)
PF02749 (2/2) Quinolinate phosphoribosyl transferase, N-terminal domain
PF01729 (2/2) Quinolinate phosphoribosyl transferase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF01047 (1/2) MarR family
PF00107 (1/2) Zinc-binding dehydrogenase
jaccard_groups_5676 172.29 +- 61.71 2 0 0 0 0.02 +- 0.02 2 6

TIGR03356 (2/2) beta-galactosidase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00331 (2/2) Glycosyl hydrolase family 10
PF00232 (2/2) Glycosyl hydrolase family 1
PF13343 (1/2) Bacterial extracellular solute-binding protein
PF04235 (1/2) Protein of unknown function (DUF418)
jaccard_groups_5672 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_2827 288.90 +- 282.94 8 0 0 0 0.03 +- 0.02 8 5

PF09339 (8/8) IclR helix-turn-helix domain
PF01614 (8/8) Bacterial transcriptional regulator
PF01494 (7/8) FAD binding domain
PF01557 (6/8) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (6/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_5678 518.00 +- 2.00 2 0 0 0 0.01 +- 0.00 2 6

PF13469 (2/2) Sulfotransferase family
PF05977 (2/2) Transmembrane secretion effector
PF02274 (2/2) Amidinotransferase
PF02065 (2/2) Melibiase
PF01583 (2/2) Adenylylsulphate kinase
PF00535 (2/2) Glycosyl transferase family 2
jaccard_groups_5818 585.00 +- 195.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR00655 (2/2) formyltetrahydrofolate deformylase
PF02219 (2/2) Methylenetetrahydrofolate reductase
PF01842 (2/2) ACT domain
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00551 (2/2) Formyl transferase
PF07676 (1/2) WD40-like Beta Propeller Repeat
jaccard_groups_5256 60.86 +- 34.51 2 0 2 0 0.21 +- 0.27 2 11

PF13560 (2/2) Helix-turn-helix domain
PF05257 (2/2) CHAP domain
PF01987 (2/2) Mitochondrial biogenesis AIM24
PF01553 (2/2) Acyltransferase
PF01047 (2/2) MarR family
PF00400 (2/2) WD domain, G-beta repeat
TIGR00843 (1/2) benzoate transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12894 (1/2) Anaphase-promoting complex subunit 4 WD40 domain
PF03594 (1/2) Benzoate membrane transport protein
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_5254 78.41 +- 22.70 2 0 2 0 0.04 +- 0.05 2 6

PF17926 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14219 (2/2) Domain of unknown function (DUF4328)
PF13354 (2/2) Beta-lactamase enzyme family
PF08044 (2/2) Domain of unknown function (DUF1707)
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
jaccard_groups_5001 1155.62 +- 779.38 2 0 1 0 0.01 +- 0.00 2 6

PF03358 (2/2) NADPH-dependent FMN reductase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01474 (2/2) Class-II DAHP synthetase family
PF00866 (2/2) Ring hydroxylating beta subunit
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (2/2) Rieske [2Fe-2S] domain
jaccard_groups_1228 110.43 +- 118.29 48 0 33 0 0.09 +- 0.10 48 5

PF02782 (48/48) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (48/48) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (47/48) Histidine phosphatase superfamily (branch 1)
PF02826 (38/48) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF07690 (36/48) Major Facilitator Superfamily
jaccard_groups_5078 212.77 +- 130.96 3 0 0 0 0.08 +- 0.11 3 19

TIGR03668 (3/3) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (3/3) probable F420-dependent oxidoreductase, Rv2161c family
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13529 (3/3) Peptidase_C39 like family
PF03547 (3/3) Membrane transport protein
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
TIGR02980 (2/3) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF12697 (2/3) Alpha/beta hydrolase family
PF07729 (2/3) FCD domain
PF06684 (2/3) Amino acid synthesis
PF04545 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
PF04539 (2/3) Sigma-70 region 3
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00171 (2/3) Aldehyde dehydrogenase family
jaccard_groups_5074 85.16 +- 50.82 3 0 0 0 0.11 +- 0.25 3 14

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14525 (3/3) AraC-binding-like domain
PF13458 (3/3) Periplasmic binding protein
PF12840 (3/3) Helix-turn-helix domain
PF12833 (3/3) Helix-turn-helix domain
PF11774 (3/3) Lsr2
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit
PF01425 (3/3) Amidase
PF00583 (3/3) Acetyltransferase (GNAT) family
jaccard_groups_5073 77.20 +- 3.09 3 0 0 0 0.10 +- 0.17 3 15

TIGR01297 (3/3) cation diffusion facilitator family transporter
TIGR01048 (3/3) diaminopimelate decarboxylase
PF16916 (3/3) Dimerisation domain of Zinc Transporter
PF03098 (3/3) Animal haem peroxidase
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01764 (3/3) Lipase (class 3)
PF01565 (3/3) FAD binding domain
PF01545 (3/3) Cation efflux family
PF01494 (3/3) FAD binding domain
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00067 (3/3) Cytochrome P450
PF08241 (2/3) Methyltransferase domain
jaccard_groups_5072 58.50 +- 1.38 3 0 3 0 0.15 +- 0.34 3 9

PF17926 (3/3) Tetracyclin repressor-like, C-terminal domain
PF13822 (3/3) Acyl-CoA carboxylase epsilon subunit
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13411 (3/3) MerR HTH family regulatory protein
PF09278 (3/3) MerR, DNA binding
PF07690 (3/3) Major Facilitator Superfamily
PF01361 (3/3) Tautomerase enzyme
PF01039 (3/3) Carboxyl transferase domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
jaccard_groups_5004 55.20 +- 30.88 2 0 2 0 0.23 +- 0.19 2 23

TIGR00765 (2/2) YihY family inner membrane protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF05922 (2/2) Peptidase inhibitor I9
PF03631 (2/2) Virulence factor BrkB
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
PF00082 (2/2) Subtilase family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
TIGR00231 (1/2) small GTP-binding protein domain
PF14492 (1/2) Elongation Factor G, domain II
PF13279 (1/2) Thioesterase-like superfamily
PF07705 (1/2) CARDB
PF03764 (1/2) Elongation factor G, domain IV
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF01263 (1/2) Aldose 1-epimerase
PF00754 (1/2) F5/8 type C domain
PF00679 (1/2) Elongation factor G C-terminus
PF00009 (1/2) Elongation factor Tu GTP binding domain
jaccard_groups_5164 464.29 +- 204.29 2 0 2 0 0.02 +- 0.01 2 8

TIGR00808 (2/2) malonate transporter, MadM subunit
TIGR00807 (2/2) malonate transporter, MadL subunit
PF17408 (2/2) Malonyl-CoA decarboxylase N-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05292 (2/2) Malonyl-CoA decarboxylase C-terminal domain
PF03818 (2/2) Malonate/sodium symporter MadM subunit
PF03817 (2/2) Malonate transporter MadL subunit
PF00501 (2/2) AMP-binding enzyme
jaccard_groups_1312 13.73 +- 2.78 2 0 0 0 0.21 +- 0.35 2 5

PF01019 (2/2) Gamma-glutamyltranspeptidase
TIGR00066 (1/2) gamma-glutamyltransferase
PF07335 (1/2) Fungal chitosanase of glycosyl hydrolase group 75
PF00459 (1/2) Inositol monophosphatase family
PF00245 (1/2) Alkaline phosphatase
jaccard_groups_1313 129.84 +- 233.05 22 0 2 0 0.16 +- 0.15 22 6

PF01557 (22/22) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (22/22) FAD binding domain
PF00903 (21/22) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF04199 (18/22) Putative cyclase
PF04909 (17/22) Amidohydrolase
PF13561 (12/22) Enoyl-(Acyl carrier protein) reductase
jaccard_groups_1317 108.60 +- 55.19 47 0 0 0 0.05 +- 0.04 47 7

PF02668 (47/47) Taurine catabolism dioxygenase TauD, TfdA family
PF01925 (47/47) Sulfite exporter TauE/SafE
PF01070 (47/47) FMN-dependent dehydrogenase
TIGR00843 (45/47) benzoate transporter
PF03594 (45/47) Benzoate membrane transport protein
PF12697 (39/47) Alpha/beta hydrolase family
PF12897 (29/47) Alanine-glyoxylate amino-transferase
jaccard_groups_5105 394.29 +- 121.22 3 0 3 0 0.02 +- 0.01 3 6

TIGR00924 (3/3) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (3/3) Dimerisation domain
PF04820 (3/3) Tryptophan halogenase
PF00891 (3/3) O-methyltransferase domain
PF00854 (3/3) POT family
PF00296 (3/3) Luciferase-like monooxygenase
jaccard_groups_88 24.97 +- 10.57 3 0 2 0 0.14 +- 0.23 3 8

PF17871 (3/3) AAA lid domain
PF10431 (3/3) C-terminal, D2-small domain, of ClpB protein
PF07724 (3/3) AAA domain (Cdc48 subfamily)
PF02861 (3/3) Clp amino terminal domain, pathogenicity island component
PF00004 (3/3) ATPase family associated with various cellular activities (AAA)
PF07690 (2/3) Major Facilitator Superfamily
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF01546 (2/3) Peptidase family M20/M25/M40
jaccard_groups_2084 49.43 +- 1.05 2 0 0 0 0.10 +- 0.05 2 5

PF12002 (2/2) MgsA AAA+ ATPase C terminal
PF04237 (2/2) YjbR
PF16193 (1/2) AAA C-terminal domain
PF05496 (1/2) Holliday junction DNA helicase RuvB P-loop domain
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
jaccard_groups_2081 89.38 +- 45.32 9 0 1 0 0.05 +- 0.06 9 2

PF07690 (9/9) Major Facilitator Superfamily
PF13302 (7/9) Acetyltransferase (GNAT) domain
jaccard_groups_4184 85.60 +- 28.46 2 0 0 0 0.12 +- 0.25 2 21

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF18130 (2/2) ATP-grasp N-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF14518 (2/2) Iron-containing redox enzyme
PF13535 (2/2) ATP-grasp domain
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00988 (2/2) Carbamoyl-phosphate synthase small chain, CPSase domain
TIGR01369 (1/2) carbamoyl-phosphate synthase, large subunit
TIGR01368 (1/2) carbamoyl-phosphate synthase, small subunit
PF02787 (1/2) Carbamoyl-phosphate synthetase large chain, oligomerisation domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02142 (1/2) MGS-like domain
PF00117 (1/2) Glutamine amidotransferase class-I
jaccard_groups_4181 162.70 +- 50.89 3 0 3 0 0.05 +- 0.06 3 7

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03466 (3/3) LysR substrate binding domain
PF01361 (3/3) Tautomerase enzyme
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00072 (3/3) Response regulator receiver domain
jaccard_groups_1956 194.60 +- 87.59 4 0 4 0 0.08 +- 0.20 4 14

TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01245 (4/4) anthranilate phosphoribosyltransferase
TIGR00566 (4/4) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF13432 (4/4) Tetratricopeptide repeat
PF13424 (4/4) Tetratricopeptide repeat
PF04715 (4/4) Anthranilate synthase component I, N terminal region
PF03704 (4/4) Bacterial transcriptional activator domain
PF02885 (4/4) Glycosyl transferase family, helical bundle domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF00931 (4/4) NB-ARC domain
PF00591 (4/4) Glycosyl transferase family, a/b domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00425 (4/4) chorismate binding enzyme
PF00117 (4/4) Glutamine amidotransferase class-I
jaccard_groups_1957 204.07 +- 154.07 7 0 0 0 0.03 +- 0.02 7 5

TIGR01323 (7/7) nitrile hydratase, alpha subunit
PF02979 (7/7) Nitrile hydratase, alpha chain
PF02211 (7/7) Nitrile hydratase beta subunit
TIGR03889 (5/7) nitrile hydratase accessory protein
TIGR03888 (5/7) nitrile hydratase, beta subunit
jaccard_groups_1796 284.11 +- 147.18 4 0 0 0 0.02 +- 0.02 4 2

PF03737 (4/4) Aldolase/RraA
PF02826 (3/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_1827 151.43 +- 132.79 4 0 0 0 0.07 +- 0.15 4 8

PF13191 (4/4) AAA ATPase domain
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF14525 (3/4) AraC-binding-like domain
PF12833 (3/4) Helix-turn-helix domain
PF12697 (2/4) Alpha/beta hydrolase family
PF10604 (2/4) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/4) Major Facilitator Superfamily
PF03055 (2/4) Retinal pigment epithelial membrane protein
jaccard_groups_1792 80.20 +- 28.94 19 0 4 0 0.20 +- 0.09 19 13

PF18603 (19/19) L-amino acid ligase C-terminal domain 2
PF18130 (19/19) ATP-grasp N-terminal domain
PF13649 (19/19) Methyltransferase domain
PF13535 (19/19) ATP-grasp domain
PF13378 (19/19) Enolase C-terminal domain-like
PF07690 (19/19) Major Facilitator Superfamily
PF02746 (19/19) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (19/19) Binding-protein-dependent transport system inner membrane component
PF00496 (19/19) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00291 (19/19) Pyridoxal-phosphate dependent enzyme
PF00005 (19/19) ABC transporter
PF04016 (15/19) Putative heavy-metal chelation
PF08352 (11/19) Oligopeptide/dipeptide transporter, C-terminal region
jaccard_groups_1793 147.02 +- 137.23 15 0 0 0 0.08 +- 0.10 15 3

PF12802 (15/15) MarR family
PF07690 (15/15) Major Facilitator Superfamily
PF00857 (15/15) Isochorismatase family
jaccard_groups_1790 66.83 +- 41.65 21 0 0 0 0.11 +- 0.12 21 7

PF08240 (20/21) Alcohol dehydrogenase GroES-like domain
PF00107 (20/21) Zinc-binding dehydrogenase
PF13561 (18/21) Enoyl-(Acyl carrier protein) reductase
PF00106 (18/21) short chain dehydrogenase
PF07690 (17/21) Major Facilitator Superfamily
PF18050 (16/21) Cyclophilin-like family
PF07883 (12/21) Cupin domain
jaccard_groups_1791 87.32 +- 32.08 16 0 4 0 0.04 +- 0.05 16 5

PF00857 (16/16) Isochorismatase family
PF11387 (15/16) Protein of unknown function (DUF2795)
PF07179 (15/16) SseB protein N-terminal domain
PF02133 (15/16) Permease for cytosine/purines, uracil, thiamine, allantoin
PF12706 (13/16) Beta-lactamase superfamily domain
jaccard_groups_1828 88.45 +- 59.36 16 0 11 0 0.17 +- 0.14 16 11

PF02837 (16/16) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (16/16) Glycosyl hydrolases family 2
PF07691 (15/16) PA14 domain
PF13407 (14/16) Periplasmic binding protein domain
PF02653 (14/16) Branched-chain amino acid transport system / permease component
PF00005 (14/16) ABC transporter
PF13377 (13/16) Periplasmic binding protein-like domain
PF00356 (13/16) Bacterial regulatory proteins, lacI family
PF13385 (12/16) Concanavalin A-like lectin/glucanases superfamily
PF08386 (12/16) TAP-like protein
PF00561 (12/16) alpha/beta hydrolase fold
jaccard_groups_1798 28.98 +- 5.53 2 0 0 0 0.09 +- 0.07 2 7

PF14267 (2/2) Domain of unknown function (DUF4357)
PF10117 (2/2) McrBC 5-methylcytosine restriction system component
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF02463 (2/2) RecF/RecN/SMC N terminal domain
PF13560 (1/2) Helix-turn-helix domain
PF13361 (1/2) UvrD-like helicase C-terminal domain
PF13245 (1/2) AAA domain
jaccard_groups_1554 128.40 +- 107.68 22 0 8 0 0.06 +- 0.11 22 8

PF13193 (22/22) AMP-binding enzyme C-terminal domain
PF02771 (22/22) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (22/22) Acyl-CoA dehydrogenase, middle domain
PF00501 (22/22) AMP-binding enzyme
PF00441 (22/22) Acyl-CoA dehydrogenase, C-terminal domain
PF14864 (13/22) Alkyl sulfatase C-terminal
PF14863 (13/22) Alkyl sulfatase dimerisation
PF00753 (13/22) Metallo-beta-lactamase superfamily
jaccard_groups_1007 135.96 +- 89.50 3 0 1 0 0.05 +- 0.08 3 5

PF16875 (3/3) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (3/3) Glycosyl hydrolase family 36 C-terminal domain
PF02065 (3/3) Melibiase
PF00754 (3/3) F5/8 type C domain
PF08306 (2/3) Glycosyl hydrolase family 98
jaccard_groups_1000 181.89 +- 158.33 7 0 1 0 0.02 +- 0.02 7 4

PF07228 (7/7) Stage II sporulation protein E (SpoIIE)
PF02607 (7/7) B12 binding domain
PF02310 (7/7) B12 binding domain
PF13466 (6/7) STAS domain
jaccard_groups_1559 267.25 +- 216.10 31 0 5 0 0.04 +- 0.07 31 4

PF00293 (31/31) NUDIX domain
PF00005 (30/31) ABC transporter
PF08241 (18/31) Methyltransferase domain
PF01135 (16/31) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
jaccard_groups_4050 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
jaccard_groups_4051 443.79 +- 206.36 4 0 0 0 0.01 +- 0.02 4 9

PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02036 (4/4) SCP-2 sterol transfer family
PF01425 (4/4) Amidase
PF00899 (4/4) ThiF family
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF12697 (3/4) Alpha/beta hydrolase family
PF03704 (3/4) Bacterial transcriptional activator domain
PF00486 (3/4) Transcriptional regulatory protein, C terminal
jaccard_groups_3959 70.64 +- 0.27 2 0 0 0 0.04 +- 0.06 2 5

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF16868 (2/2) NMT1-like family
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
jaccard_groups_3956 712.26 +- 656.94 4 0 4 0 0.05 +- 0.19 4 17

TIGR03026 (4/4) nucleotide sugar dehydrogenase
PF13578 (4/4) Methyltransferase domain
PF13191 (4/4) AAA ATPase domain
PF05199 (4/4) GMC oxidoreductase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03704 (4/4) Bacterial transcriptional activator domain
PF01266 (4/4) FAD dependent oxidoreductase
PF01061 (4/4) ABC-2 type transporter
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00732 (4/4) GMC oxidoreductase
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/4) ABC transporter
PF02801 (2/4) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/4) Acyl transferase domain
PF00109 (2/4) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_3957 855.20 +- 102.65 5 0 5 4 0.01 +- 0.00 5 11

TIGR00027 (5/5) methyltransferase, TIGR00027 family
PF11066 (5/5) Protein of unknown function (DUF2867)
PF08028 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF07366 (5/5) SnoaL-like polyketide cyclase
PF04072 (5/5) Leucine carboxyl methyltransferase
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF00155 (5/5) Aminotransferase class I and II
TIGR01536 (4/5) asparagine synthase (glutamine-hydrolyzing)
PF13537 (4/5) Glutamine amidotransferase domain
PF12146 (4/5) Serine aminopeptidase, S33
PF00733 (4/5) Asparagine synthase
jaccard_groups_3955 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
jaccard_groups_3953 625.07 +- 496.01 5 0 0 0 0.02 +- 0.02 5 10

PF07729 (5/5) FCD domain
PF07690 (5/5) Major Facilitator Superfamily
PF05378 (5/5) Hydantoinase/oxoprolinase N-terminal region
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02538 (5/5) Hydantoinase B/oxoprolinase
PF01968 (5/5) Hydantoinase/oxoprolinase
PF01558 (5/5) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF00857 (5/5) Isochorismatase family
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00155 (5/5) Aminotransferase class I and II
jaccard_groups_1178 487.59 +- 467.59 13 0 1 13 0.03 +- 0.12 13 3

TIGR00702 (13/13) YcaO-type kinase domain
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF07812 (12/13) TfuA-like protein
jaccard_groups_4451 32.20 +- 11.98 3 0 0 0 0.12 +- 0.23 3 5

TIGR02246 (3/3) conserved hypothetical protein
PF14534 (3/3) Domain of unknown function (DUF4440)
PF04149 (3/3) Domain of unknown function (DUF397)
PF01738 (3/3) Dienelactone hydrolase family
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_4457 2023.52 +- 1169.56 4 0 0 0 0.03 +- 0.09 4 20

PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13692 (4/4) Glycosyl transferases group 1
PF13489 (4/4) Methyltransferase domain
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF12708 (4/4) Pectate lyase superfamily protein
PF04101 (4/4) Glycosyltransferase family 28 C-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02566 (4/4) OsmC-like protein
PF01979 (4/4) Amidohydrolase family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00664 (4/4) ABC transporter transmembrane region
PF00155 (4/4) Aminotransferase class I and II
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
TIGR01179 (3/4) UDP-glucose 4-epimerase GalE
PF16363 (3/4) GDP-mannose 4,6 dehydratase
PF07883 (3/4) Cupin domain
PF13641 (2/4) Glycosyltransferase like family 2
PF03704 (2/4) Bacterial transcriptional activator domain
PF00486 (2/4) Transcriptional regulatory protein, C terminal
jaccard_groups_1171 342.40 +- 275.51 60 0 2 0 0.04 +- 0.02 60 11

TIGR01733 (60/60) amino acid adenylation domain
PF11695 (60/60) Domain of unknown function (DUF3291)
PF07859 (60/60) alpha/beta hydrolase fold
PF01494 (60/60) FAD binding domain
PF00583 (60/60) Acetyltransferase (GNAT) family
PF00581 (60/60) Rhodanese-like domain
PF00501 (60/60) AMP-binding enzyme
PF07883 (59/60) Cupin domain
PF09334 (58/60) tRNA synthetases class I (M)
PF13434 (56/60) L-lysine 6-monooxygenase (NADPH-requiring)
PF01266 (56/60) FAD dependent oxidoreductase
jaccard_groups_6327 334.62 +- 22.62 2 0 2 0 0.03 +- 0.01 2 6

PF13560 (2/2) Helix-turn-helix domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00400 (2/2) WD domain, G-beta repeat
jaccard_groups_189 60.90 +- 29.69 14 0 0 0 0.21 +- 0.29 14 7

TIGR03445 (14/14) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF07730 (14/14) Histidine kinase
PF02585 (14/14) GlcNAc-PI de-N-acetylase
PF00005 (13/14) ABC transporter
PF12698 (12/14) ABC-2 family transporter protein
PF00196 (12/14) Bacterial regulatory proteins, luxR family
PF00072 (12/14) Response regulator receiver domain
jaccard_groups_185 59.72 +- 34.04 4 0 1 0 0.10 +- 0.19 4 4

TIGR00254 (4/4) diguanylate cyclase (GGDEF) domain
PF00990 (4/4) Diguanylate cyclase, GGDEF domain
TIGR00229 (2/4) PAS domain S-box protein
PF10935 (2/4) Protein of unknown function (DUF2637)
jaccard_groups_187 326.63 +- 12.50 2 0 0 0 0.02 +- 0.01 2 11

PF17863 (2/2) AAA lid domain
PF07726 (2/2) ATPase family associated with various cellular activities (AAA)
PF01882 (2/2) Protein of unknown function DUF58
PF13559 (1/2) Domain of unknown function (DUF4129)
PF13519 (1/2) von Willebrand factor type A domain
PF12804 (1/2) MobA-like NTP transferase domain
PF07584 (1/2) Aerotolerance regulator N-terminal
PF01841 (1/2) Transglutaminase-like superfamily
PF01580 (1/2) FtsK/SpoIIIE family
PF00877 (1/2) NlpC/P60 family
PF00069 (1/2) Protein kinase domain
jaccard_groups_183 30.39 +- 23.42 9 0 0 0 0.11 +- 0.12 9 2

PF14200 (9/9) Ricin-type beta-trefoil lectin domain-like
PF04616 (6/9) Glycosyl hydrolases family 43
jaccard_groups_182 155.40 +- 249.34 53 0 4 0 0.11 +- 0.14 53 4

PF01915 (53/53) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (53/53) Glycosyl hydrolase family 3 N terminal domain
PF14310 (48/53) Fibronectin type III-like domain
PF00528 (28/53) Binding-protein-dependent transport system inner membrane component
jaccard_groups_237 44.01 +- 3.88 2 0 2 0 0.09 +- 0.18 2 4

TIGR00377 (2/2) anti-anti-sigma factor
PF01740 (2/2) STAS domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_236 25.21 +- 1.02 2 0 0 0 0.08 +- 0.13 2 7

PF00480 (2/2) ROK family
PF13551 (1/2) Winged helix-turn helix
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF07940 (1/2) Heparinase II/III-like protein
PF05448 (1/2) Acetyl xylan esterase (AXE1)
PF00027 (1/2) Cyclic nucleotide-binding domain
jaccard_groups_232 308.19 +- 252.20 41 0 17 0 0.04 +- 0.11 41 3

PF02801 (41/41) Beta-ketoacyl synthase, C-terminal domain
PF00109 (38/41) Beta-ketoacyl synthase, N-terminal domain
PF00550 (35/41) Phosphopantetheine attachment site
jaccard_groups_231 127.23 +- 108.42 18 0 2 0 0.10 +- 0.18 18 4

TIGR01180 (18/18) putative alpha-1,2-mannosidase
PF17678 (18/18) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (18/18) Glycosyl hydrolase family 92
PF00754 (14/18) F5/8 type C domain
jaccard_groups_230 316.05 +- 439.26 245 27 216 245 0.03 +- 0.04 218 4

PF00733 (244/245) Asparagine synthase
PF13471 (243/245) Transglutaminase-like superfamily
PF05402 (169/245) Coenzyme PQQ synthesis protein D (PqqD)
PF00005 (128/245) ABC transporter
jaccard_groups_81 92.60 +- 131.79 30 0 3 2 0.07 +- 0.09 30 1

PF13649 (30/30) Methyltransferase domain
jaccard_groups_80 130.30 +- 91.69 3 0 1 0 0.02 +- 0.03 3 2

PF12840 (3/3) Helix-turn-helix domain
PF08327 (2/3) Activator of Hsp90 ATPase homolog 1-like protein
jaccard_groups_87 88.26 +- 144.87 121 0 53 0 0.11 +- 0.17 121 6

PF00941 (121/121) FAD binding domain in molybdopterin dehydrogenase
PF02738 (120/121) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (120/121) [2Fe-2S] binding domain
PF01315 (120/121) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF03450 (110/121) CO dehydrogenase flavoprotein C-terminal domain
PF00111 (106/121) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_85 105.41 +- 58.50 2 0 0 0 0.10 +- 0.16 2 11

PF02371 (2/2) Transposase IS116/IS110/IS902 family
PF01548 (2/2) Transposase
PF12697 (1/2) Alpha/beta hydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF01979 (1/2) Amidohydrolase family
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_84 127.44 +- 89.22 2 0 0 0 0.04 +- 0.04 2 8

PF13358 (2/2) DDE superfamily endonuclease
TIGR04364 (1/2) methyltransferase, FxLD system
PF13592 (1/2) Winged helix-turn helix
PF13565 (1/2) Homeodomain-like domain
PF13551 (1/2) Winged helix-turn helix
PF07859 (1/2) alpha/beta hydrolase fold
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00067 (1/2) Cytochrome P450
jaccard_groups_4521 147.65 +- 42.12 3 0 0 0 0.03 +- 0.03 3 8

PF16951 (3/3) Putative methionine and alanine importer, small subunit
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
PF00209 (3/3) Sodium:neurotransmitter symporter family
TIGR00842 (2/3) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02028 (2/3) BCCT, betaine/carnitine/choline family transporter
PF00085 (2/3) Thioredoxin
jaccard_groups_4526 169.56 +- 115.57 3 0 0 0 0.10 +- 0.25 3 13

PF04041 (3/3) beta-1,4-mannooligosaccharide phosphorylase
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00128 (3/3) Alpha amylase, catalytic domain
PF13377 (2/3) Periplasmic binding protein-like domain
PF11941 (2/3) Domain of unknown function (DUF3459)
PF02880 (2/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/3) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF00408 (2/3) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00356 (2/3) Bacterial regulatory proteins, lacI family
jaccard_groups_4524 137.42 +- 29.42 2 0 0 0 0.09 +- 0.12 2 9

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF03008 (1/2) Archaea bacterial proteins of unknown function
PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_4237 799.78 +- 559.84 4 0 1 4 0.02 +- 0.04 4 14

PF17676 (4/4) LD-carboxypeptidase C-terminal domain
PF13581 (4/4) Histidine kinase-like ATPase domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13280 (4/4) WYL domain
PF08279 (4/4) HTH domain
PF04055 (4/4) Radical SAM superfamily
PF02310 (4/4) B12 binding domain
PF02016 (4/4) LD-carboxypeptidase N-terminal domain
PF00730 (4/4) HhH-GPD superfamily base excision DNA repair protein
PF00293 (4/4) NUDIX domain
PF00152 (4/4) tRNA synthetases class II (D, K and N)
PF00005 (4/4) ABC transporter
PF03372 (2/4) Endonuclease/Exonuclease/phosphatase family
PF01135 (2/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
jaccard_groups_4235 43.30 +- 8.66 3 0 1 0 0.18 +- 0.19 3 17

TIGR00474 (3/3) L-seryl-tRNA(Sec) selenium transferase
PF13247 (3/3) 4Fe-4S dicluster domain
PF12838 (3/3) 4Fe-4S dicluster domain
PF12390 (3/3) Selenocysteine synthase N terminal
PF04879 (3/3) Molybdopterin oxidoreductase Fe4S4 domain
PF03916 (3/3) Polysulphide reductase, NrfD
PF03841 (3/3) L-seryl-tRNA selenium transferase
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
PF00009 (3/3) Elongation factor Tu GTP binding domain
TIGR00476 (2/3) selenide, water dikinase
TIGR00475 (2/3) selenocysteine-specific translation elongation factor
PF09107 (2/3) Elongation factor SelB, winged helix
PF02769 (2/3) AIR synthase related protein, C-terminal domain
PF00586 (2/3) AIR synthase related protein, N-terminal domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00005 (2/3) ABC transporter
jaccard_groups_3885 145.69 +- 108.33 3 0 0 0 0.04 +- 0.04 3 2

TIGR01428 (3/3) haloacid dehalogenase, type II
PF00702 (3/3) haloacid dehalogenase-like hydrolase
jaccard_groups_4988 237.28 +- 57.47 3 0 0 0 0.06 +- 0.09 3 15

TIGR01451 (3/3) conserved repeat domain
TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF18029 (3/3) Glyoxalase-like domain
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF12831 (3/3) FAD dependent oxidoreductase
PF07971 (3/3) Glycosyl hydrolase family 92
PF07730 (3/3) Histidine kinase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
jaccard_groups_4239 281.99 +- 177.86 4 0 4 0 0.06 +- 0.20 4 4

PF06500 (4/4) Alpha/beta hydrolase of unknown function (DUF1100)
PF01494 (4/4) FAD binding domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00198 (4/4) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
jaccard_groups_2694 144.61 +- 96.53 7 0 0 0 0.09 +- 0.19 7 9

PF17765 (6/7) MmyB-like transcription regulator ligand binding domain
PF13560 (6/7) Helix-turn-helix domain
PF07690 (6/7) Major Facilitator Superfamily
PF00248 (6/7) Aldo/keto reductase family
PF00106 (6/7) short chain dehydrogenase
PF13561 (5/7) Enoyl-(Acyl carrier protein) reductase
PF02627 (5/7) Carboxymuconolactone decarboxylase family
PF01494 (5/7) FAD binding domain
PF03992 (4/7) Antibiotic biosynthesis monooxygenase
jaccard_groups_3689 19.59 +- 0.00 3 0 0 0 0.15 +- 0.17 3 5

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF04542 (3/3) Sigma-70 region 2
PF04264 (3/3) YceI-like domain
PF01471 (3/3) Putative peptidoglycan binding domain
PF00413 (3/3) Matrixin
jaccard_groups_3408 133.87 +- 64.11 5 0 0 0 0.05 +- 0.15 5 3

PF13343 (5/5) Bacterial extracellular solute-binding protein
PF00561 (5/5) alpha/beta hydrolase fold
PF00485 (5/5) Phosphoribulokinase / Uridine kinase family
jaccard_groups_4557 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_3400 24.14 +- 4.42 3 0 1 0 0.16 +- 0.10 3 5

TIGR02798 (3/3) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF04909 (3/3) Amidohydrolase
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF00083 (3/3) Sugar (and other) transporter
jaccard_groups_3403 201.54 +- 70.75 6 0 1 0 0.05 +- 0.14 6 20

TIGR03860 (6/6) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01733 (6/6) amino acid adenylation domain
TIGR01341 (6/6) aconitate hydratase 1
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF13535 (6/6) ATP-grasp domain
PF13378 (6/6) Enolase C-terminal domain-like
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01613 (6/6) Flavin reductase like domain
PF00694 (6/6) Aconitase C-terminal domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00330 (6/6) Aconitase family (aconitate hydratase)
PF00296 (6/6) Luciferase-like monooxygenase
PF00285 (6/6) Citrate synthase, C-terminal domain
PF07690 (5/6) Major Facilitator Superfamily
PF02826 (5/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02518 (4/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00072 (4/6) Response regulator receiver domain
PF02786 (3/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
jaccard_groups_3405 337.71 +- 311.77 6 0 0 0 0.09 +- 0.24 6 11

TIGR00556 (6/6) phosphopantetheine--protein transferase domain
TIGR00027 (6/6) methyltransferase, TIGR00027 family
PF11583 (6/6) P-aminobenzoate N-oxygenase AurF
PF07690 (6/6) Major Facilitator Superfamily
PF04072 (6/6) Leucine carboxyl methyltransferase
PF01648 (6/6) 4'-phosphopantetheinyl transferase superfamily
PF01575 (6/6) MaoC like domain
PF12706 (4/6) Beta-lactamase superfamily domain
PF06628 (4/6) Catalase-related immune-responsive
PF00550 (4/6) Phosphopantetheine attachment site
PF00199 (4/6) Catalase
jaccard_groups_3315 820.61 +- 469.39 2 0 1 2 0.03 +- 0.05 2 6

PF13471 (2/2) Transglutaminase-like superfamily
PF00400 (2/2) WD domain, G-beta repeat
PF00326 (2/2) Prolyl oligopeptidase family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
jaccard_groups_4553 630.06 +- 384.39 3 0 1 0 0.02 +- 0.01 3 5

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF04616 (3/3) Glycosyl hydrolases family 43
PF02018 (3/3) Carbohydrate binding domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF13229 (2/3) Right handed beta helix region
jaccard_groups_529 167.47 +- 85.77 7 0 0 0 0.02 +- 0.01 7 1

PF04655 (7/7) Aminoglycoside/hydroxyurea antibiotic resistance kinase
jaccard_groups_522 31.24 +- 20.45 3 0 0 0 0.12 +- 0.25 3 2

PF03747 (3/3) ADP-ribosylglycohydrolase
PF00293 (2/3) NUDIX domain
jaccard_groups_521 131.26 +- 107.93 5 0 0 0 0.06 +- 0.09 5 1

PF11387 (5/5) Protein of unknown function (DUF2795)
jaccard_groups_520 27.48 +- 7.98 2 0 0 0 0.08 +- 0.06 2 7

PF13202 (2/2) EF hand
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF13833 (1/2) EF-hand domain pair
PF13499 (1/2) EF-hand domain pair
PF08448 (1/2) PAS fold
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF00027 (1/2) Cyclic nucleotide-binding domain
jaccard_groups_527 157.24 +- 105.16 4 0 0 0 0.04 +- 0.09 4 4

TIGR00026 (4/4) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (4/4) F420H(2)-dependent quinone reductase
PF00106 (2/4) short chain dehydrogenase
PF00005 (2/4) ABC transporter
jaccard_groups_526 430.00 +- 121.62 3 0 0 0 0.01 +- 0.00 3 3

TIGR00654 (3/3) phenazine biosynthesis protein, PhzF family
PF02567 (3/3) Phenazine biosynthesis-like protein
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
jaccard_groups_524 144.17 +- 101.64 3 0 0 0 0.13 +- 0.24 3 5

TIGR04416 (3/3) group II intron reverse transcriptase/maturase
PF08388 (3/3) Group II intron, maturase-specific domain
PF00078 (3/3) Reverse transcriptase (RNA-dependent DNA polymerase)
PF13655 (2/3) N-terminal domain of reverse transcriptase
PF01844 (2/3) HNH endonuclease
jaccard_groups_426 76.92 +- 0.48 2 0 0 0 0.05 +- 0.06 2 8

TIGR01891 (2/2) amidohydrolase
PF07859 (2/2) alpha/beta hydrolase fold
PF01546 (2/2) Peptidase family M20/M25/M40
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF01425 (1/2) Amidase
PF00501 (1/2) AMP-binding enzyme
PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_424 44.93 +- 28.59 3 0 0 0 0.21 +- 0.34 3 11

TIGR03535 (3/3) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
PF14789 (3/3) Tetrahydrodipicolinate N-succinyltransferase middle
PF14602 (3/3) Hexapeptide repeat of succinyl-transferase
PF17940 (2/3) Tetracyclin repressor-like, C-terminal domain
PF14019 (2/3) Protein of unknown function (DUF4235)
PF12277 (2/3) Protein of unknown function (DUF3618)
PF08281 (2/3) Sigma-70, region 4
PF07332 (2/3) Putative Actinobacterial Holin-X, holin superfamily III
PF04542 (2/3) Sigma-70 region 2
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_3538 121.94 +- 93.06 2 0 0 0 0.03 +- 0.04 2 4

PF01494 (2/2) FAD binding domain
PF00106 (2/2) short chain dehydrogenase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF00459 (1/2) Inositol monophosphatase family
jaccard_groups_420 112.46 +- 149.16 12 0 3 3 0.10 +- 0.19 12 3

PF00041 (11/12) Fibronectin type III domain
PF00704 (10/12) Glycosyl hydrolases family 18
PF02018 (8/12) Carbohydrate binding domain
jaccard_groups_428 86.63 +- 233.60 29 0 5 1 0.13 +- 0.18 29 2

PF00174 (29/29) Oxidoreductase molybdopterin binding domain
PF01292 (25/29) Prokaryotic cytochrome b561
jaccard_groups_3533 163.45 +- 141.42 6 0 6 0 0.14 +- 0.25 6 20

TIGR01733 (6/6) amino acid adenylation domain
TIGR01720 (6/6) non-ribosomal peptide synthase domain TIGR01720
TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08021 (6/6) Siderophore-interacting FAD-binding domain
PF07690 (6/6) Major Facilitator Superfamily
PF04954 (6/6) Siderophore-interacting protein
PF01497 (6/6) Periplasmic binding protein
PF01032 (6/6) FecCD transport family
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00005 (6/6) ABC transporter
TIGR04316 (4/6) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
TIGR00034 (4/6) 3-deoxy-7-phosphoheptulonate synthase
PF13561 (4/6) Enoyl-(Acyl carrier protein) reductase
PF00857 (4/6) Isochorismatase family
PF00793 (4/6) DAHP synthetase I family
TIGR00543 (3/6) isochorismate synthase
PF00425 (3/6) chorismate binding enzyme
jaccard_groups_2049 117.55 +- 130.23 13 0 1 0 0.09 +- 0.11 13 5

PF00535 (12/13) Glycosyl transferase family 2
PF07690 (11/13) Major Facilitator Superfamily
PF00877 (10/13) NlpC/P60 family
PF07728 (7/13) AAA domain (dynein-related subfamily)
PF03771 (7/13) Domain of unknown function (DUF317)
jaccard_groups_2043 67.48 +- 4.29 3 0 0 0 0.18 +- 0.23 3 15

TIGR02980 (3/3) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF05227 (3/3) CHASE3 domain
PF04545 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF04539 (3/3) Sigma-70 region 3
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01047 (3/3) MarR family
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00072 (3/3) Response regulator receiver domain
jaccard_groups_2042 46.48 +- 37.71 10 0 0 0 0.10 +- 0.08 10 6

TIGR03668 (10/10) PPOX class probable F420-dependent enzyme, Rv0121 family
PF01243 (10/10) Pyridoxamine 5'-phosphate oxidase
TIGR03619 (9/10) probable F420-dependent oxidoreductase, Rv2161c family
PF00296 (9/10) Luciferase-like monooxygenase
PF02133 (7/10) Permease for cytosine/purines, uracil, thiamine, allantoin
PF04199 (6/10) Putative cyclase
jaccard_groups_2046 77.54 +- 107.93 6 0 0 0 0.08 +- 0.05 6 3

TIGR01733 (6/6) amino acid adenylation domain
PF00501 (6/6) AMP-binding enzyme
PF00378 (6/6) Enoyl-CoA hydratase/isomerase
jaccard_groups_2045 150.89 +- 148.80 9 0 4 0 0.08 +- 0.15 9 13

PF13560 (9/9) Helix-turn-helix domain
PF12900 (9/9) Pyridoxamine 5'-phosphate oxidase
PF08240 (9/9) Alcohol dehydrogenase GroES-like domain
PF00107 (9/9) Zinc-binding dehydrogenase
TIGR01509 (8/9) HAD hydrolase, family IA, variant 3
PF12724 (8/9) Flavodoxin domain
PF12679 (8/9) ABC-2 family transporter protein
PF08962 (8/9) Domain of unknown function (DUF1876)
PF03636 (8/9) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (8/9) Glycosyl hydrolase family 65 central catalytic domain
PF00702 (8/9) haloacid dehalogenase-like hydrolase
PF00582 (8/9) Universal stress protein family
PF00005 (8/9) ABC transporter
jaccard_groups_6103 348.30 +- 38.70 2 0 2 0 0.01 +- 0.00 2 3

PF06339 (2/2) Ectoine synthase
PF01425 (2/2) Amidase
PF00668 (2/2) Condensation domain
jaccard_groups_2133 66.12 +- 39.81 3 0 0 0 0.19 +- 0.22 3 3

PF13411 (3/3) MerR HTH family regulatory protein
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01427 (2/3) D-ala-D-ala dipeptidase
jaccard_groups_2132 25.47 +- 0.05 2 0 0 0 0.24 +- 0.13 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13426 (2/2) PAS domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04616 (2/2) Glycosyl hydrolases family 43
PF01095 (2/2) Pectinesterase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00067 (2/2) Cytochrome P450
jaccard_groups_6104 61.59 +- 38.28 2 0 0 0 0.10 +- 0.13 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF01636 (2/2) Phosphotransferase enzyme family
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF12833 (1/2) Helix-turn-helix domain
PF12697 (1/2) Alpha/beta hydrolase family
PF03466 (1/2) LysR substrate binding domain
PF01965 (1/2) DJ-1/PfpI family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_289 456.81 +- 496.95 233 0 14 12 0.04 +- 0.08 233 6

PF00082 (228/233) Subtilase family
PF06013 (213/233) Proteins of 100 residues with WXG
TIGR03930 (211/233) WXG100 family type VII secretion target
PF05108 (197/233) Type VII secretion system ESX-1, transport TM domain B
TIGR03921 (196/233) type VII secretion-associated serine protease mycosin
TIGR03919 (181/233) type VII secretion protein EccB
jaccard_groups_2138 56.54 +- 25.80 5 0 0 0 0.10 +- 0.09 5 5

PF04149 (5/5) Domain of unknown function (DUF397)
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family
PF13411 (3/5) MerR HTH family regulatory protein
PF00248 (3/5) Aldo/keto reductase family
jaccard_groups_2911 382.43 +- 479.69 9 0 9 9 0.10 +- 0.26 9 6

PF06114 (9/9) IrrE N-terminal-like domain
PF05147 (9/9) Lanthionine synthetase C-like protein
PF02687 (9/9) FtsX-like permease family
PF00082 (9/9) Subtilase family
PF00069 (9/9) Protein kinase domain
PF00005 (9/9) ABC transporter
jaccard_groups_2913 24.31 +- 6.48 9 0 0 0 0.09 +- 0.11 9 3

PF11203 (9/9) Putative type VII ESX secretion system translocon, EccE
PF00877 (9/9) NlpC/P60 family
PF02195 (5/9) ParB-like nuclease domain
jaccard_groups_2912 51.73 +- 17.07 2 0 0 0 0.05 +- 0.05 2 3

PF13581 (2/2) Histidine kinase-like ATPase domain
PF00670 (2/2) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00293 (2/2) NUDIX domain
jaccard_groups_2914 95.75 +- 21.85 2 0 0 0 0.17 +- 0.20 2 19

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF14310 (2/2) Fibronectin type III-like domain
PF13560 (2/2) Helix-turn-helix domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04149 (1/2) Domain of unknown function (DUF397)
PF03795 (1/2) YCII-related domain
PF00553 (1/2) Cellulose binding domain
PF00331 (1/2) Glycosyl hydrolase family 10
jaccard_groups_2916 72.22 +- 58.93 6 0 1 0 0.12 +- 0.25 6 6

PF13459 (6/6) 4Fe-4S single cluster domain
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00067 (6/6) Cytochrome P450
PF13556 (4/6) PucR C-terminal helix-turn-helix domain
PF00005 (4/6) ABC transporter
PF07681 (3/6) DoxX
jaccard_groups_3622 157.16 +- 135.21 4 0 0 0 0.04 +- 0.05 4 6

TIGR03086 (4/4) TIGR03086 family protein
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08546 (4/4) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (4/4) Ketopantoate reductase PanE/ApbA
PF08002 (3/4) Protein of unknown function (DUF1697)
PF01323 (3/4) DSBA-like thioredoxin domain
jaccard_groups_3628 1561.57 +- 1191.59 6 0 1 0 0.02 +- 0.01 6 13

TIGR01263 (6/6) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF14696 (6/6) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (6/6) ATP-grasp domain
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (6/6) Prephenate dehydrogenase
PF01613 (6/6) Flavin reductase like domain
PF01070 (6/6) FMN-dependent dehydrogenase
PF00903 (6/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (6/6) Luciferase-like monooxygenase
PF00155 (6/6) Aminotransferase class I and II
PF18130 (5/6) ATP-grasp N-terminal domain
PF00106 (3/6) short chain dehydrogenase
jaccard_groups_2269 133.03 +- 108.08 12 0 12 0 0.06 +- 0.12 12 10

TIGR01733 (12/12) amino acid adenylation domain
PF00975 (12/12) Thioesterase domain
PF00550 (12/12) Phosphopantetheine attachment site
PF00501 (12/12) AMP-binding enzyme
PF14681 (9/12) Uracil phosphoribosyltransferase
PF13419 (9/12) Haloacid dehalogenase-like hydrolase
PF04227 (9/12) Indigoidine synthase A like protein
PF01361 (9/12) Tautomerase enzyme
PF07690 (7/12) Major Facilitator Superfamily
TIGR01509 (6/12) HAD hydrolase, family IA, variant 3
jaccard_groups_2595 49.09 +- 19.55 11 0 0 0 0.15 +- 0.26 11 8

PF09594 (11/11) Glycosyltransferase family 87
PF03088 (11/11) Strictosidine synthase
PF12840 (10/11) Helix-turn-helix domain
PF07745 (8/11) Glycosyl hydrolase family 53
TIGR03814 (6/11) glutaminase A
TIGR00494 (6/11) protein CrcB
PF04960 (6/11) Glutaminase
PF02537 (6/11) CrcB-like protein, Camphor Resistance (CrcB)
jaccard_groups_2597 395.45 +- 116.96 11 0 7 11 0.01 +- 0.00 11 4

PF07690 (11/11) Major Facilitator Superfamily
PF02624 (11/11) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF13649 (9/11) Methyltransferase domain
PF05711 (9/11) Macrocin-O-methyltransferase (TylF)
jaccard_groups_2596 180.86 +- 113.47 5 0 0 0 0.04 +- 0.03 5 10

TIGR01591 (5/5) formate dehydrogenase, alpha subunit
PF13187 (5/5) 4Fe-4S dicluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF01257 (5/5) Thioredoxin-like [2Fe-2S] ferredoxin
PF00384 (5/5) Molybdopterin oxidoreductase
PF13510 (4/5) 2Fe-2S iron-sulfur cluster binding domain
PF07690 (3/5) Major Facilitator Superfamily
jaccard_groups_2263 236.69 +- 112.12 4 0 0 0 0.03 +- 0.03 4 6

PF01636 (4/4) Phosphotransferase enzyme family
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (4/4) NUDIX domain
PF13649 (3/4) Methyltransferase domain
PF07690 (3/4) Major Facilitator Superfamily
PF02899 (2/4) Phage integrase, N-terminal SAM-like domain
jaccard_groups_2262 52.13 +- 5.65 7 0 0 0 0.21 +- 0.38 7 6

PF12840 (7/7) Helix-turn-helix domain
PF05175 (7/7) Methyltransferase small domain
PF01061 (7/7) ABC-2 type transporter
PF00005 (7/7) ABC transporter
TIGR00041 (6/7) dTMP kinase
PF02223 (6/7) Thymidylate kinase
jaccard_groups_5488 1046.84 +- 773.16 2 0 1 2 0.01 +- 0.02 2 12

PF13649 (2/2) Methyltransferase domain
PF13632 (2/2) Glycosyl transferase family group 2
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (2/2) Glycosyl transferase family 2
TIGR04426 (1/2) TDP-4-amino-4,6-dideoxy-D-glucose deaminase
PF16363 (1/2) GDP-mannose 4,6 dehydratase
PF13578 (1/2) Methyltransferase domain
PF06182 (1/2) ABC-2 family transporter protein
PF00005 (1/2) ABC transporter
jaccard_groups_5489 24.39 +- 5.96 2 0 0 0 0.09 +- 0.11 2 5

TIGR00099 (2/2) Cof-like hydrolase
PF12161 (2/2) HsdM N-terminal domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
jaccard_groups_6366 758.21 +- 660.79 2 0 0 0 0.07 +- 0.23 2 14

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03417 (2/2) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01321 (2/2) Creatinase/Prolidase N-terminal domain
PF00557 (2/2) Metallopeptidase family M24
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF18364 (1/2) Molybdopterin oxidoreductase N-terminal domain
PF13454 (1/2) FAD-NAD(P)-binding
PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF00384 (1/2) Molybdopterin oxidoreductase
jaccard_groups_6367 160.86 +- 68.07 2 0 2 0 0.11 +- 0.28 2 18

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16911 (2/2) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF09339 (2/2) IclR helix-turn-helix domain
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/2) CoA-transferase family III
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (2/2) Bacterial transcriptional regulator
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_6364 186.14 +- 8.86 2 0 0 0 0.03 +- 0.01 2 9

PF13808 (2/2) DDE_Tnp_1-associated
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01609 (2/2) Transposase DDE domain
PF01596 (2/2) O-methyltransferase
PF01494 (2/2) FAD binding domain
PF00581 (2/2) Rhodanese-like domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_6360 1129.14 +- 297.14 2 0 0 0 0.03 +- 0.02 2 20

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07702 (2/2) UTRA domain
PF06283 (2/2) Trehalose utilisation
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02728 (2/2) Copper amine oxidase, N3 domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01179 (2/2) Copper amine oxidase, enzyme domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF01869 (1/2) BadF/BadG/BcrA/BcrD ATPase family
PF00480 (1/2) ROK family
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_2862 629.58 +- 226.83 10 0 5 0 0.01 +- 0.01 10 11

PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF12710 (10/10) haloacid dehalogenase-like hydrolase
PF07690 (10/10) Major Facilitator Superfamily
PF00501 (10/10) AMP-binding enzyme
TIGR01490 (9/10) HAD hydrolase, family IB
PF13561 (9/10) Enoyl-(Acyl carrier protein) reductase
PF05655 (9/10) Pseudomonas avirulence D protein (AvrD)
PF01648 (9/10) 4'-phosphopantetheinyl transferase superfamily
PF00975 (9/10) Thioesterase domain
PF00753 (9/10) Metallo-beta-lactamase superfamily
PF00550 (9/10) Phosphopantetheine attachment site
jaccard_groups_2681 171.19 +- 56.94 4 0 0 0 0.01 +- 0.01 4 4

TIGR00447 (4/4) aminoacyl-tRNA hydrolase
PF11303 (4/4) Protein of unknown function (DUF3105)
PF03713 (4/4) Domain of unknown function (DUF305)
PF01195 (4/4) Peptidyl-tRNA hydrolase
jaccard_groups_2680 725.24 +- 513.13 11 0 0 0 0.03 +- 0.04 11 8

PF13561 (11/11) Enoyl-(Acyl carrier protein) reductase
PF09084 (11/11) NMT1/THI5 like
PF03737 (11/11) Aldolase/RraA
PF03466 (11/11) LysR substrate binding domain
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF00294 (11/11) pfkB family carbohydrate kinase
PF00126 (11/11) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (11/11) ABC transporter
jaccard_groups_6369 318.70 +- 79.35 2 0 1 0 0.05 +- 0.04 2 19

TIGR02299 (2/2) 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
TIGR02295 (2/2) 3,4-dihydroxyphenylacetate 2,3-dioxygenase
TIGR00674 (2/2) 4-hydroxy-tetrahydrodipicolinate synthase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF03737 (2/2) Aldolase/RraA
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR00745 (1/2) 2-dehydropantoate 2-reductase
PF13343 (1/2) Bacterial extracellular solute-binding protein
PF12802 (1/2) MarR family
PF12680 (1/2) SnoaL-like domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01323 (1/2) DSBA-like thioredoxin domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
jaccard_groups_5803 134.22 +- 18.67 2 0 2 0 0.03 +- 0.05 2 4

PF13560 (2/2) Helix-turn-helix domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00756 (2/2) Putative esterase
jaccard_groups_738 53.84 +- 28.16 14 0 0 0 0.15 +- 0.22 14 7

PF00082 (13/14) Subtilase family
PF00005 (13/14) ABC transporter
PF02687 (11/14) FtsX-like permease family
PF17964 (9/14) Bacterial Ig domain
PF03734 (9/14) L,D-transpeptidase catalytic domain
PF03992 (8/14) Antibiotic biosynthesis monooxygenase
PF01152 (8/14) Bacterial-like globin
jaccard_groups_5801 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_5808 229.33 +- 114.67 2 0 2 0 0.02 +- 0.02 2 4

PF07681 (2/2) DoxX
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF02515 (2/2) CoA-transferase family III
PF00285 (2/2) Citrate synthase, C-terminal domain
jaccard_groups_2661 260.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF04199 (2/2) Putative cyclase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00550 (1/2) Phosphopantetheine attachment site
jaccard_groups_2660 75.00 +- 55.00 2 0 0 0 0.06 +- 0.08 2 5

PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF08305 (2/2) NPCBM/NEW2 domain
PF01055 (1/2) Glycosyl hydrolases family 31
PF00884 (1/2) Sulfatase
PF00135 (1/2) Carboxylesterase family
jaccard_groups_2665 87.21 +- 28.34 2 0 0 0 0.11 +- 0.15 2 18

PF13183 (2/2) 4Fe-4S dicluster domain
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01565 (2/2) FAD binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00106 (2/2) short chain dehydrogenase
TIGR02778 (1/2) DNA ligase D, polymerase domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13244 (1/2) Domain of unknown function (DUF4040)
PF04066 (1/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (1/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (1/2) Na+/H+ antiporter subunit
PF02754 (1/2) Cysteine-rich domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00723 (1/2) Glycosyl hydrolases family 15
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/2) Proton-conducting membrane transporter
jaccard_groups_2668 306.87 +- 141.49 11 0 6 0 0.03 +- 0.07 11 4

PF02633 (11/11) Creatinine amidohydrolase
PF01180 (11/11) Dihydroorotate dehydrogenase
PF07690 (9/11) Major Facilitator Superfamily
PF05014 (7/11) Nucleoside 2-deoxyribosyltransferase
jaccard_groups_2460 146.09 +- 103.87 8 0 8 0 0.18 +- 0.23 8 14

TIGR01733 (8/8) amino acid adenylation domain
TIGR01720 (8/8) non-ribosomal peptide synthase domain TIGR01720
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF01382 (8/8) Avidin family
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00106 (8/8) short chain dehydrogenase
TIGR01727 (5/8) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (5/8) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (5/8) Binding-protein-dependent transport system inner membrane component
PF00496 (5/8) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (5/8) ABC transporter
jaccard_groups_2463 20.00 +- 0.00 2 0 0 0 0.20 +- 0.13 2 9

PF17964 (2/2) Bacterial Ig domain
PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01614 (2/2) Bacterial transcriptional regulator
PF00722 (2/2) Glycosyl hydrolases family 16
PF00083 (2/2) Sugar (and other) transporter
jaccard_groups_2465 71.00 +- 19.00 2 0 0 0 0.04 +- 0.01 2 7

PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF00561 (1/2) alpha/beta hydrolase fold
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_2468 138.29 +- 119.71 2 0 0 0 0.07 +- 0.19 2 2

PF02666 (2/2) Phosphatidylserine decarboxylase
PF00450 (2/2) Serine carboxypeptidase
jaccard_groups_5666 580.50 +- 193.50 2 0 0 0 0.01 +- 0.01 2 5

PF13577 (2/2) SnoaL-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF01638 (1/2) HxlR-like helix-turn-helix
jaccard_groups_5667 48.84 +- 19.96 2 0 0 0 0.05 +- 0.08 2 4

PF13581 (2/2) Histidine kinase-like ATPase domain
PF04248 (2/2) Domain of unknown function (DUF427)
PF01323 (2/2) DSBA-like thioredoxin domain
PF00561 (2/2) alpha/beta hydrolase fold
jaccard_groups_5664 72.68 +- 43.43 2 0 2 0 0.06 +- 0.08 2 7

TIGR04539 (2/2) tRNA-dependent cyclodipeptide synthase
TIGR00654 (2/2) phenazine biosynthesis protein, PhzF family
PF16715 (2/2) Cyclodipeptide synthase
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02567 (2/2) Phenazine biosynthesis-like protein
PF00144 (2/2) Beta-lactamase
PF00067 (2/2) Cytochrome P450
jaccard_groups_5247 150.03 +- 21.03 2 0 1 0 0.03 +- 0.01 2 6

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_5243 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
jaccard_groups_5248 3841.96 +- 544.04 2 0 2 2 0.01 +- 0.00 2 18

TIGR01179 (2/2) UDP-glucose 4-epimerase GalE
PF13350 (2/2) Tyrosine phosphatase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF04055 (2/2) Radical SAM superfamily
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00326 (2/2) Prolyl oligopeptidase family
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
TIGR01733 (1/2) amino acid adenylation domain
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01841 (1/2) Transglutaminase-like superfamily
PF00668 (1/2) Condensation domain
PF00534 (1/2) Glycosyl transferases group 1
jaccard_groups_889 18.12 +- 2.41 3 0 0 0 0.20 +- 0.25 3 7

PF17928 (3/3) Tetracyclin repressor-like, C-terminal domain
PF08402 (3/3) TOBE domain
PF04879 (3/3) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00384 (3/3) Molybdopterin oxidoreductase
PF00005 (3/3) ABC transporter
jaccard_groups_881 324.11 +- 228.78 9 0 3 2 0.06 +- 0.09 9 8

TIGR00126 (9/9) deoxyribose-phosphate aldolase
PF13407 (9/9) Periplasmic binding protein domain
PF07702 (9/9) UTRA domain
PF05025 (9/9) RbsD / FucU transport protein family
PF00392 (9/9) Bacterial regulatory proteins, gntR family
PF00005 (9/9) ABC transporter
PF02653 (8/9) Branched-chain amino acid transport system / permease component
PF00294 (8/9) pfkB family carbohydrate kinase
jaccard_groups_2556 24.81 +- 14.19 2 0 0 0 0.11 +- 0.11 2 8

PF13749 (2/2) Putative ATP-dependent DNA helicase recG C-terminal
PF04326 (2/2) Putative DNA-binding domain
PF13614 (1/2) AAA domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF03793 (1/2) PASTA domain
PF02810 (1/2) SEC-C motif
PF00877 (1/2) NlpC/P60 family
PF00293 (1/2) NUDIX domain
jaccard_groups_5063 119.56 +- 47.42 3 0 0 0 0.11 +- 0.16 3 12

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01297 (3/3) cation diffusion facilitator family transporter
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF01545 (3/3) Cation efflux family
PF01022 (3/3) Bacterial regulatory protein, arsR family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF13489 (2/3) Methyltransferase domain
PF13377 (2/3) Periplasmic binding protein-like domain
PF00356 (2/3) Bacterial regulatory proteins, lacI family
jaccard_groups_957 25.33 +- 10.14 10 0 9 0 0.17 +- 0.22 10 6

TIGR01181 (10/10) dTDP-glucose 4,6-dehydratase
PF16363 (10/10) GDP-mannose 4,6 dehydratase
PF00483 (8/10) Nucleotidyl transferase
TIGR01214 (6/10) dTDP-4-dehydrorhamnose reductase
TIGR01208 (6/10) glucose-1-phosphate thymidylyltransferase
PF04321 (6/10) RmlD substrate binding domain
jaccard_groups_955 203.03 +- 174.03 9 0 4 0 0.05 +- 0.08 9 6

PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF00550 (8/9) Phosphopantetheine attachment site
TIGR00747 (5/9) 3-oxoacyl-[acyl-carrier-protein] synthase III
jaccard_groups_5110 62.47 +- 18.15 2 0 0 0 0.05 +- 0.07 2 6

PF14100 (2/2) Methane oxygenase PmoA
PF13229 (2/2) Right handed beta helix region
PF07602 (2/2) Protein of unknown function (DUF1565)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_1365 44.99 +- 75.33 12 0 4 0 0.14 +- 0.19 12 5

TIGR02434 (12/12) precorrin-6A synthase (deacetylating)
PF00590 (12/12) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF03745 (11/12) Domain of unknown function (DUF309)
TIGR00711 (6/12) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (6/12) Major Facilitator Superfamily
jaccard_groups_5113 572.06 +- 280.11 3 0 2 0 0.01 +- 0.01 3 7

PF13669 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13454 (3/3) FAD-NAD(P)-binding
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF12897 (2/3) Alanine-glyoxylate amino-transferase
jaccard_groups_1363 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
jaccard_groups_1361 14.04 +- 0.09 2 0 0 0 0.14 +- 0.06 2 3

PF18143 (2/2) HAD domain in Swiss Army Knife RNA repair proteins
PF13649 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
jaccard_groups_1360 42.37 +- 34.45 6 0 1 0 0.09 +- 0.09 6 3

PF02738 (6/6) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (6/6) [2Fe-2S] binding domain
PF00111 (6/6) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_1369 26.94 +- 7.85 24 0 4 0 0.18 +- 0.17 24 17

TIGR03346 (24/24) ATP-dependent chaperone protein ClpB
TIGR02350 (24/24) chaperone protein DnaK
PF17871 (24/24) AAA lid domain
PF10431 (24/24) C-terminal, D2-small domain, of ClpB protein
PF07992 (24/24) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (24/24) AAA domain (Cdc48 subfamily)
PF02861 (24/24) Clp amino terminal domain, pathogenicity island component
PF01556 (24/24) DnaJ C terminal domain
PF01025 (24/24) GrpE
PF00226 (24/24) DnaJ domain
PF00085 (24/24) Thioredoxin
PF00027 (24/24) Cyclic nucleotide-binding domain
PF00012 (24/24) Hsp70 protein
PF00004 (24/24) ATPase family associated with various cellular activities (AAA)
TIGR01068 (23/24) thioredoxin
PF13591 (23/24) MerR HTH family regulatory protein
PF02148 (22/24) Zn-finger in ubiquitin-hydrolases and other protein
jaccard_groups_1368 37.28 +- 5.92 9 0 1 0 0.20 +- 0.27 9 7

TIGR02276 (9/9) 40-residue YVTN family beta-propeller repeat
PF17964 (9/9) Bacterial Ig domain
PF03734 (9/9) L,D-transpeptidase catalytic domain
PF01522 (9/9) Polysaccharide deacetylase
TIGR04215 (8/9) choice-of-anchor A domain
PF17802 (8/9) Prealbumin-like fold domain
PF13499 (8/9) EF-hand domain pair
jaccard_groups_2688 75.73 +- 46.38 5 0 0 0 0.06 +- 0.06 5 8

TIGR01180 (5/5) putative alpha-1,2-mannosidase
PF17678 (5/5) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (5/5) Glycosyl hydrolase family 92
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (5/5) HAMP domain
PF00553 (5/5) Cellulose binding domain
PF00512 (5/5) His Kinase A (phospho-acceptor) domain
PF03067 (4/5) Lytic polysaccharide mono-oxygenase, cellulose-degrading
jaccard_groups_1969 31.71 +- 1.94 2 0 0 0 0.09 +- 0.09 2 4

PF09992 (2/2) Phosphodiester glycosidase
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF05036 (2/2) Sporulation related domain
PF00756 (2/2) Putative esterase
jaccard_groups_1968 43.64 +- 21.40 13 0 0 0 0.08 +- 0.11 13 6

PF12802 (13/13) MarR family
PF12680 (13/13) SnoaL-like domain
PF01323 (13/13) DSBA-like thioredoxin domain
PF00753 (13/13) Metallo-beta-lactamase superfamily
PF13377 (7/13) Periplasmic binding protein-like domain
PF00356 (7/13) Bacterial regulatory proteins, lacI family
jaccard_groups_1960 664.02 +- 187.25 3 0 1 3 0.02 +- 0.02 3 8

TIGR04267 (3/3) HEXXH motif domain
TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF04055 (3/3) Radical SAM superfamily
PF02223 (3/3) Thymidylate kinase
PF00293 (3/3) NUDIX domain
PF00144 (3/3) Beta-lactamase
PF00069 (3/3) Protein kinase domain
PF00248 (2/3) Aldo/keto reductase family
jaccard_groups_1963 29.36 +- 4.55 2 0 0 0 0.13 +- 0.14 2 7

PF01081 (2/2) KDPG and KHG aldolase
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00255 (1/2) Glutathione peroxidase
PF00067 (1/2) Cytochrome P450
jaccard_groups_1768 291.82 +- 117.81 5 0 3 0 0.01 +- 0.01 5 3

PF05401 (5/5) Nodulation protein S (NodS)
PF02585 (5/5) GlcNAc-PI de-N-acetylase
PF00535 (4/5) Glycosyl transferase family 2
jaccard_groups_1811 271.67 +- 266.53 3 0 3 0 0.11 +- 0.18 3 5

PF13523 (3/3) Acetyltransferase (GNAT) domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF06276 (3/3) Ferric iron reductase FhuF-like transporter
PF04183 (3/3) IucA / IucC family
PF00282 (3/3) Pyridoxal-dependent decarboxylase conserved domain
jaccard_groups_1813 99.64 +- 117.43 18 0 2 0 0.09 +- 0.13 18 3

PF07690 (18/18) Major Facilitator Superfamily
PF05721 (16/18) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (13/18) Condensation domain
jaccard_groups_1766 172.01 +- 83.27 7 0 0 0 0.02 +- 0.02 7 13

TIGR00557 (7/7) 4-hydroxythreonine-4-phosphate dehydrogenase PdxA
PF17042 (7/7) Nucleotide-binding C-terminal domain
PF08220 (7/7) DeoR-like helix-turn-helix domain
PF07690 (7/7) Major Facilitator Superfamily
PF07005 (7/7) Sugar-binding N-terminal domain
PF04166 (7/7) Pyridoxal phosphate biosynthetic protein PdxA
PF00455 (7/7) DeoR C terminal sensor domain
PF13396 (5/7) Phospholipase_D-nuclease N-terminal
PF09851 (5/7) Short C-terminal domain
PF17203 (4/7) Single cache domain 3
PF13581 (4/7) Histidine kinase-like ATPase domain
PF13185 (4/7) GAF domain
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
jaccard_groups_1563 91.69 +- 91.54 23 0 1 0 0.16 +- 0.14 23 11

PF02837 (23/23) Glycosyl hydrolases family 2, sugar binding domain
PF16353 (22/23) Domain of unknown function(DUF4981)
PF04030 (22/23) D-arabinono-1,4-lactone oxidase
PF02929 (22/23) Beta galactosidase small chain
PF02836 (22/23) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (22/23) FAD binding domain
PF00528 (22/23) Binding-protein-dependent transport system inner membrane component
PF00480 (22/23) ROK family
PF13412 (17/23) Winged helix-turn-helix DNA-binding
PF01547 (13/23) Bacterial extracellular solute-binding protein
PF00005 (12/23) ABC transporter
jaccard_groups_1567 56.06 +- 19.08 34 0 0 0 0.15 +- 0.13 34 12

TIGR00247 (34/34) conserved hypothetical protein, YceG family
PF07729 (34/34) FCD domain
PF07690 (34/34) Major Facilitator Superfamily
PF02618 (34/34) YceG-like family
PF00392 (33/34) Bacterial regulatory proteins, gntR family
TIGR01048 (31/34) diaminopimelate decarboxylase
PF02784 (31/34) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
TIGR00026 (28/34) deazaflavin-dependent oxidoreductase, nitroreductase family
PF18029 (28/34) Glyoxalase-like domain
PF13411 (28/34) MerR HTH family regulatory protein
PF09278 (28/34) MerR, DNA binding
PF04075 (28/34) F420H(2)-dependent quinone reductase
jaccard_groups_1583 92.33 +- 61.75 2 0 0 0 0.08 +- 0.15 2 9

PF14606 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF06580 (2/2) Histidine kinase
PF04397 (2/2) LytTr DNA-binding domain
PF03640 (2/2) Secreted repeat of unknown function
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00474 (2/2) Sodium:solute symporter family
PF00296 (2/2) Luciferase-like monooxygenase
PF00072 (2/2) Response regulator receiver domain
jaccard_groups_1582 62.33 +- 67.59 30 0 1 0 0.12 +- 0.08 30 8

PF04303 (30/30) PrpF protein
PF03737 (30/30) Aldolase/RraA
PF07729 (29/30) FCD domain
PF00903 (29/30) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (29/30) Bacterial regulatory proteins, gntR family
PF07690 (28/30) Major Facilitator Superfamily
PF02585 (27/30) GlcNAc-PI de-N-acetylase
TIGR03211 (22/30) catechol 2,3 dioxygenase
jaccard_groups_4739 42.17 +- 14.56 2 0 2 0 0.11 +- 0.20 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF05834 (2/2) Lycopene cyclase protein
PF02082 (2/2) Transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
jaccard_groups_4086 188.50 +- 57.91 4 0 0 0 0.02 +- 0.01 4 8

TIGR03620 (4/4) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (4/4) MmyB-like transcription regulator ligand binding domain
PF16884 (4/4) N-terminal domain of oxidoreductase
PF13560 (4/4) Helix-turn-helix domain
PF12680 (4/4) SnoaL-like domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00107 (4/4) Zinc-binding dehydrogenase
PF00106 (2/4) short chain dehydrogenase
jaccard_groups_4083 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase
jaccard_groups_1584 216.25 +- 216.94 8 0 7 6 0.03 +- 0.03 8 4

TIGR04539 (8/8) tRNA-dependent cyclodipeptide synthase
PF16715 (8/8) Cyclodipeptide synthase
PF00881 (6/8) Nitroreductase family
PF00089 (6/8) Trypsin
jaccard_groups_4733 32.68 +- 0.44 3 0 0 0 0.12 +- 0.14 3 4

PF13701 (3/3) Transposase DDE domain group 1
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01476 (3/3) LysM domain
PF00248 (3/3) Aldo/keto reductase family
jaccard_groups_1588 91.94 +- 87.83 5 0 0 0 0.04 +- 0.05 5 2

PF08877 (5/5) MepB protein
PF00501 (3/5) AMP-binding enzyme
jaccard_groups_4089 383.00 +- 93.28 4 0 3 0 0.01 +- 0.01 4 7

PF08031 (4/4) Berberine and berberine like
PF03704 (4/4) Bacterial transcriptional activator domain
PF01565 (4/4) FAD binding domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
TIGR00026 (2/4) deazaflavin-dependent oxidoreductase, nitroreductase family
PF07366 (2/4) SnoaL-like polyketide cyclase
PF04075 (2/4) F420H(2)-dependent quinone reductase
jaccard_groups_4088 294.42 +- 273.36 4 0 3 0 0.08 +- 0.23 4 14

TIGR00223 (4/4) aspartate 1-decarboxylase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02261 (4/4) Aspartate decarboxylase
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00107 (4/4) Zinc-binding dehydrogenase
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF01613 (3/4) Flavin reductase like domain
PF00561 (2/4) alpha/beta hydrolase fold
jaccard_groups_4424 1191.19 +- 1181.25 4 1 1 4 0.05 +- 0.18 3 22

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/4) Methyltransferase domain
PF07993 (4/4) Male sterility protein
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF03176 (4/4) MMPL family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/4) MOSC domain
PF01575 (3/4) MaoC like domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF05193 (2/4) Peptidase M16 inactive domain
PF03476 (2/4) MOSC N-terminal beta barrel domain
PF00106 (2/4) short chain dehydrogenase
jaccard_groups_1108 16.43 +- 4.27 9 0 1 0 0.16 +- 0.13 9 3

PF11583 (9/9) P-aminobenzoate N-oxygenase AurF
PF07992 (9/9) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (9/9) 4Fe-4S binding domain
jaccard_groups_1104 150.84 +- 84.55 5 0 0 0 0.06 +- 0.12 5 4

PF17103 (5/5) Stealth protein CR4, conserved region 4
PF17102 (5/5) Stealth protein CR3, conserved region 3
PF17101 (5/5) Stealth protein CR1, conserved region 1
PF11380 (5/5) Stealth protein CR2, conserved region 2
jaccard_groups_1101 21.31 +- 3.98 3 0 0 0 0.15 +- 0.28 3 1

PF09848 (3/3) Uncharacterized conserved protein (DUF2075)
jaccard_groups_4428 18.69 +- 4.79 4 0 4 4 0.17 +- 0.13 4 7

TIGR04187 (4/4) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (4/4) putative ATP-grasp target RiPP
TIGR03943 (4/4) TIGR03943 family protein
PF14404 (4/4) Ribosomally synthesized peptide in Streptomyces species
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF03773 (4/4) Predicted permease
PF02852 (4/4) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
jaccard_groups_3324 303.76 +- 124.51 6 0 0 6 0.03 +- 0.10 6 5

TIGR04267 (6/6) HEXXH motif domain
PF13186 (6/6) Iron-sulfur cluster-binding domain
PF04055 (6/6) Radical SAM superfamily
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00067 (6/6) Cytochrome P450
jaccard_groups_94 42.01 +- 12.20 6 0 2 0 0.23 +- 0.40 6 9

TIGR01051 (6/6) DNA topoisomerase I
PF13368 (6/6) Topoisomerase C-terminal repeat
PF01751 (6/6) Toprim domain
PF01131 (6/6) DNA topoisomerase
TIGR00041 (4/6) dTMP kinase
PF05175 (4/6) Methyltransferase small domain
PF02223 (4/6) Thymidylate kinase
PF00561 (4/6) alpha/beta hydrolase fold
PF13177 (3/6) DNA polymerase III, delta subunit
jaccard_groups_95 161.74 +- 102.82 3 0 0 0 0.08 +- 0.21 3 2

PF13460 (3/3) NAD(P)H-binding
PF00248 (2/3) Aldo/keto reductase family
jaccard_groups_96 143.93 +- 136.62 3 0 0 1 0.06 +- 0.07 3 2

PF13412 (3/3) Winged helix-turn-helix DNA-binding
PF01037 (3/3) Lrp/AsnC ligand binding domain
jaccard_groups_97 127.51 +- 108.93 30 0 5 0 0.04 +- 0.08 30 2

PF08241 (30/30) Methyltransferase domain
PF00067 (19/30) Cytochrome P450
jaccard_groups_90 36.68 +- 6.32 2 0 0 0 0.09 +- 0.09 2 6

PF13546 (2/2) DDE superfamily endonuclease
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF05977 (1/2) Transmembrane secretion effector
PF05270 (1/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF01609 (1/2) Transposase DDE domain
jaccard_groups_92 452.54 +- 492.07 23 0 4 0 0.09 +- 0.15 23 2

PF00528 (23/23) Binding-protein-dependent transport system inner membrane component
PF01547 (22/23) Bacterial extracellular solute-binding protein
jaccard_groups_4885 401.61 +- 29.35 3 0 3 0 0.02 +- 0.01 3 11

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF03795 (3/3) YCII-related domain
PF02310 (3/3) B12 binding domain
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00107 (3/3) Zinc-binding dehydrogenase
jaccard_groups_4884 643.39 +- 207.52 3 0 3 0 0.01 +- 0.01 3 10

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00155 (3/3) Aminotransferase class I and II
PF00107 (3/3) Zinc-binding dehydrogenase
PF14696 (2/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
jaccard_groups_98 78.43 +- 66.84 395 0 1 0 0.19 +- 0.31 395 11

PF00482 (394/395) Type II secretion system (T2SS), protein F
PF00437 (392/395) Type II/IV secretion system protein
PF07811 (390/395) TadE-like protein
TIGR03177 (384/395) Flp pilus assembly protein CpaB
PF16976 (384/395) Flp pilus assembly protein RcpC/CpaB
PF00691 (368/395) OmpA family
PF13614 (352/395) AAA domain
PF13400 (317/395) Putative Flp pilus-assembly TadE/G-like
PF00072 (312/395) Response regulator receiver domain
PF00196 (311/395) Bacterial regulatory proteins, luxR family
PF07730 (294/395) Histidine kinase
jaccard_groups_99 142.49 +- 184.42 70 0 13 8 0.08 +- 0.12 70 1

PF00296 (70/70) Luciferase-like monooxygenase
jaccard_groups_1611 111.28 +- 76.49 9 0 1 0 0.13 +- 0.12 9 4

PF07690 (9/9) Major Facilitator Superfamily
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00583 (7/9) Acetyltransferase (GNAT) family
jaccard_groups_1610 90.80 +- 106.53 34 0 2 32 0.12 +- 0.23 34 10

TIGR00710 (34/34) drug resistance transporter, Bcr/CflA subfamily
PF12833 (34/34) Helix-turn-helix domain
PF07690 (34/34) Major Facilitator Superfamily
PF00067 (33/34) Cytochrome P450
TIGR01536 (32/34) asparagine synthase (glutamine-hydrolyzing)
PF13537 (32/34) Glutamine amidotransferase domain
PF02195 (32/34) ParB-like nuclease domain
PF00733 (32/34) Asparagine synthase
PF00291 (32/34) Pyridoxal-phosphate dependent enzyme
PF00132 (32/34) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_4951 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
jaccard_groups_4950 393.40 +- 239.84 3 0 3 0 0.12 +- 0.31 3 20

TIGR02039 (3/3) sulfate adenylyltransferase, small subunit
TIGR02034 (3/3) sulfate adenylyltransferase, large subunit
TIGR00670 (3/3) aspartate carbamoyltransferase
TIGR00455 (3/3) adenylyl-sulfate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01583 (3/3) Adenylylsulphate kinase
PF01507 (3/3) Phosphoadenosine phosphosulfate reductase family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00459 (3/3) Inositol monophosphatase family
PF00326 (3/3) Prolyl oligopeptidase family
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
PF00009 (3/3) Elongation factor Tu GTP binding domain
jaccard_groups_4955 2762.67 +- 988.06 3 0 3 0 0.01 +- 0.00 3 13

TIGR03297 (3/3) phosphonopyruvate decarboxylase
TIGR00045 (3/3) glycerate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF02595 (3/3) Glycerate kinase family
PF01061 (3/3) ABC-2 type transporter
PF00696 (3/3) Amino acid kinase family
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00266 (3/3) Aminotransferase class-V
PF00005 (3/3) ABC transporter
jaccard_groups_4958 182.92 +- 27.92 3 0 3 0 0.17 +- 0.34 3 11

PF13424 (3/3) Tetratricopeptide repeat
PF06259 (3/3) Alpha/beta hydrolase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01757 (3/3) Acyltransferase family
PF01177 (3/3) Asp/Glu/Hydantoin racemase
PF01061 (3/3) ABC-2 type transporter
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
jaccard_groups_3439 577.56 +- 422.41 6 0 6 0 0.08 +- 0.23 6 18

PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF14765 (6/6) Polyketide synthase dehydratase
PF08659 (6/6) KR domain
PF04820 (6/6) Tryptophan halogenase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00975 (6/6) Thioesterase domain
PF00698 (6/6) Acyl transferase domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00107 (5/6) Zinc-binding dehydrogenase
PF13191 (4/6) AAA ATPase domain
PF01613 (4/6) Flavin reductase like domain
PF03704 (3/6) Bacterial transcriptional activator domain
PF00931 (3/6) NB-ARC domain
PF00486 (3/6) Transcriptional regulatory protein, C terminal
PF00067 (3/6) Cytochrome P450
jaccard_groups_258 46.11 +- 25.91 4 0 0 0 0.14 +- 0.29 4 3

PF00271 (4/4) Helicase conserved C-terminal domain
PF00176 (4/4) SNF2 family N-terminal domain
PF12419 (2/4) SNF2 Helicase protein
jaccard_groups_3434 26.70 +- 12.90 3 0 0 0 0.10 +- 0.12 3 5

PF01513 (3/3) ATP-NAD kinase
PF00188 (3/3) Cysteine-rich secretory protein family
PF00067 (3/3) Cytochrome P450
PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF13560 (2/3) Helix-turn-helix domain
jaccard_groups_3436 124.57 +- 47.72 4 0 0 0 0.04 +- 0.04 4 10

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/4) Sigma-70, region 4
PF07883 (4/4) Cupin domain
PF04542 (4/4) Sigma-70 region 2
TIGR00778 (3/4) alkylhydroperoxidase AhpD family core domain
PF07690 (3/4) Major Facilitator Superfamily
PF02627 (3/4) Carboxymuconolactone decarboxylase family
PF01966 (3/4) HD domain
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
PF00107 (2/4) Zinc-binding dehydrogenase
jaccard_groups_3433 187.85 +- 156.51 6 0 2 0 0.12 +- 0.14 6 8

TIGR03356 (6/6) beta-galactosidase
PF13802 (6/6) Galactose mutarotase-like
PF13416 (6/6) Bacterial extracellular solute-binding protein
PF01055 (6/6) Glycosyl hydrolases family 31
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00232 (6/6) Glycosyl hydrolase family 1
PF13377 (4/6) Periplasmic binding protein-like domain
PF00356 (4/6) Bacterial regulatory proteins, lacI family
jaccard_groups_3981 80.95 +- 63.65 5 0 1 0 0.13 +- 0.27 5 8

TIGR00236 (5/5) UDP-N-acetylglucosamine 2-epimerase
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13517 (5/5) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08031 (5/5) Berberine and berberine like
PF07690 (5/5) Major Facilitator Superfamily
PF02350 (5/5) UDP-N-acetylglucosamine 2-epimerase
PF01757 (5/5) Acyltransferase family
PF01565 (5/5) FAD binding domain
jaccard_groups_3980 88.49 +- 77.91 5 0 5 0 0.14 +- 0.34 5 16

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03756 (5/5) A-factor biosynthesis hotdog domain
TIGR01490 (4/5) HAD hydrolase, family IB
PF12710 (4/5) haloacid dehalogenase-like hydrolase
PF12680 (4/5) SnoaL-like domain
PF07690 (4/5) Major Facilitator Superfamily
PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain
PF01636 (4/5) Phosphotransferase enzyme family
PF01144 (4/5) Coenzyme A transferase
PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain
PF02771 (3/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/5) Acyl-CoA dehydrogenase, middle domain
PF01494 (3/5) FAD binding domain
PF00441 (3/5) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_3982 332.68 +- 190.70 4 0 0 0 0.03 +- 0.04 4 9

PF03466 (4/4) LysR substrate binding domain
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
PF09339 (3/4) IclR helix-turn-helix domain
PF03328 (3/4) HpcH/HpaI aldolase/citrate lyase family
PF02776 (3/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01614 (3/4) Bacterial transcriptional regulator
PF01522 (3/4) Polysaccharide deacetylase
PF00561 (3/4) alpha/beta hydrolase fold
jaccard_groups_3322 176.81 +- 124.49 7 0 7 0 0.03 +- 0.03 7 12

TIGR01733 (7/7) amino acid adenylation domain
PF13640 (7/7) 2OG-Fe(II) oxygenase superfamily
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF07993 (7/7) Male sterility protein
PF05118 (7/7) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00106 (7/7) short chain dehydrogenase
TIGR01746 (5/7) thioester reductase domain
PF18130 (5/7) ATP-grasp N-terminal domain
jaccard_groups_3989 789.48 +- 524.82 5 0 1 0 0.02 +- 0.08 5 11

PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01613 (5/5) Flavin reductase like domain
PF00296 (5/5) Luciferase-like monooxygenase
TIGR03944 (4/5) 2,3-diaminopropionate biosynthesis protein SbnB
PF14518 (4/5) Iron-containing redox enzyme
PF02423 (4/5) Ornithine cyclodeaminase/mu-crystallin family
PF00069 (3/5) Protein kinase domain
jaccard_groups_3988 209.25 +- 39.90 5 0 1 0 0.03 +- 0.02 5 8

TIGR00069 (5/5) histidinol dehydrogenase
PF12697 (5/5) Alpha/beta hydrolase family
PF07883 (5/5) Cupin domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF00815 (5/5) Histidinol dehydrogenase
PF00106 (5/5) short chain dehydrogenase
PF07690 (4/5) Major Facilitator Superfamily
PF07366 (4/5) SnoaL-like polyketide cyclase
jaccard_groups_558 95.61 +- 105.35 7 0 4 0 0.11 +- 0.19 7 1

PF00756 (7/7) Putative esterase
jaccard_groups_559 114.40 +- 202.34 90 0 77 89 0.08 +- 0.11 90 7

TIGR03882 (89/90) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (89/90) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (89/90) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF07730 (78/90) Histidine kinase
PF00196 (70/90) Bacterial regulatory proteins, luxR family
PF00072 (70/90) Response regulator receiver domain
PF12840 (63/90) Helix-turn-helix domain
jaccard_groups_556 65.35 +- 72.12 21 0 5 0 0.09 +- 0.14 21 1

PF00150 (21/21) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_555 64.47 +- 16.41 7 0 3 0 0.19 +- 0.27 7 5

PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00005 (7/7) ABC transporter
PF04069 (5/7) Substrate binding domain of ABC-type glycine betaine transport system
TIGR01186 (4/7) glycine betaine/L-proline transport ATP binding subunit
PF00171 (4/7) Aldehyde dehydrogenase family
jaccard_groups_550 31.32 +- 15.64 3 0 0 0 0.12 +- 0.25 3 4

PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF16945 (2/3) Putative lactococcus lactis phage r1t holin
PF08924 (2/3) Domain of unknown function (DUF1906)
jaccard_groups_551 24.11 +- 31.09 8 0 0 0 0.21 +- 0.36 8 5

TIGR01549 (8/8) HAD hydrolase, family IA, variant 1
PF17197 (8/8) Domain of unknown function (DUF5134)
PF01435 (8/8) Peptidase family M48
PF00702 (8/8) haloacid dehalogenase-like hydrolase
PF01569 (7/8) PAP2 superfamily
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_jaccard_groups_2057 114.10 +- 111.67 15 0 14 0 0.09 +- 0.24 15 6

PF13649 (15/15) Methyltransferase domain
PF03621 (15/15) MbtH-like protein
PF02668 (15/15) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (15/15) Aminotransferase class I and II
PF07592 (14/15) Rhodopirellula transposase DDE domain
PF13349 (13/15) Putative adhesin
precursor_jaccard_groups_41063 245.92 +- 75.21 2 0 0 0 0.06 +- 0.13 2 14

PF13802 (2/2) Galactose mutarotase-like
PF13641 (2/2) Glycosyltransferase like family 2
PF13570 (2/2) PQQ-like domain
PF06182 (2/2) ABC-2 family transporter protein
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF01055 (2/2) Glycosyl hydrolases family 31
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00005 (2/2) ABC transporter
PF13377 (1/2) Periplasmic binding protein-like domain
PF00877 (1/2) NlpC/P60 family
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_628 22.48 +- 9.12 9 0 0 0 0.21 +- 0.33 9 11

TIGR02937 (9/9) RNA polymerase sigma factor, sigma-70 family
TIGR00554 (9/9) pantothenate kinase
TIGR00271 (9/9) uncharacterized hydrophobic domain
PF08281 (9/9) Sigma-70, region 4
PF04542 (9/9) Sigma-70 region 2
PF04149 (9/9) Domain of unknown function (DUF397)
PF04087 (9/9) Domain of unknown function (DUF389)
PF00485 (9/9) Phosphoribulokinase / Uridine kinase family
PF13560 (8/9) Helix-turn-helix domain
PF07228 (7/9) Stage II sporulation protein E (SpoIIE)
PF00903 (6/9) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_27651 112.04 +- 73.04 2 0 2 0 0.14 +- 0.26 2 20

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02127 (2/2) Aminopeptidase I zinc metalloprotease (M18)
PF01145 (2/2) SPFH domain / Band 7 family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (1/2) amino acid adenylation domain
PF12158 (1/2) Protein of unknown function (DUF3592)
PF00877 (1/2) NlpC/P60 family
precursor_jaccard_groups_41413 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_12142 21.35 +- 5.35 4 0 0 0 0.18 +- 0.09 4 6

PF16157 (4/4) Domain of unknown function (DUF4865)
PF07883 (4/4) Cupin domain
PF02126 (4/4) Phosphotriesterase family
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF14552 (3/4) Tautomerase enzyme
PF01361 (3/4) Tautomerase enzyme
precursor_jaccard_groups_37851 181.17 +- 52.17 2 0 0 0 0.03 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF07179 (1/2) SseB protein N-terminal domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_8042 109.83 +- 98.18 6 0 5 0 0.07 +- 0.08 6 6

PF07690 (6/6) Major Facilitator Superfamily
PF05893 (6/6) Acyl-CoA reductase (LuxC)
PF04443 (6/6) Acyl-protein synthetase, LuxE
PF01553 (6/6) Acyltransferase
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00501 (5/6) AMP-binding enzyme
precursor_jaccard_groups_37735 352.88 +- 167.12 2 0 2 2 0.02 +- 0.03 2 8

TIGR00702 (2/2) YcaO-type kinase domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF07812 (2/2) TfuA-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02543 (2/2) Carbamoyltransferase N-terminus
PF12802 (1/2) MarR family
precursor_jaccard_groups_8162 20.81 +- 7.45 2 0 0 0 0.17 +- 0.13 2 8

TIGR00045 (2/2) glycerate kinase
PF02595 (2/2) Glycerate kinase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (2/2) Sodium:sulfate symporter transmembrane region
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_22399 17.52 +- 1.02 3 0 0 0 0.23 +- 0.33 3 11

PF14509 (3/3) Glycosyl-hydrolase 97 C-terminal, oligomerisation
PF14508 (3/3) Glycosyl-hydrolase 97 N-terminal
PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF10566 (3/3) Glycoside hydrolase 97
PF08305 (3/3) NPCBM/NEW2 domain
PF07730 (3/3) Histidine kinase
PF03176 (3/3) MMPL family
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00069 (3/3) Protein kinase domain
precursor_jaccard_groups_10230 40.22 +- 17.68 5 0 0 0 0.11 +- 0.06 5 10

TIGR00745 (5/5) 2-dehydropantoate 2-reductase
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13412 (5/5) Winged helix-turn-helix DNA-binding
PF13404 (5/5) AsnC-type helix-turn-helix domain
PF08546 (5/5) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (5/5) Major Facilitator Superfamily
PF02558 (5/5) Ketopantoate reductase PanE/ApbA
PF01546 (5/5) Peptidase family M20/M25/M40
PF01522 (5/5) Polysaccharide deacetylase
PF01037 (5/5) Lrp/AsnC ligand binding domain
precursor_jaccard_groups_4483 26.83 +- 5.46 6 0 0 0 0.08 +- 0.04 6 2

PF02734 (6/6) DAK2 domain
PF02733 (6/6) Dak1 domain
precursor_jaccard_groups_12568 145.93 +- 80.58 4 0 0 0 0.05 +- 0.04 4 12

TIGR01167 (4/4) LPXTG cell wall anchor domain
PF18130 (4/4) ATP-grasp N-terminal domain
PF17802 (4/4) Prealbumin-like fold domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF04828 (4/4) Glutathione-dependent formaldehyde-activating enzyme
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF00583 (4/4) Acetyltransferase (GNAT) family
PF01555 (3/4) DNA methylase
precursor_jaccard_groups_8684 213.71 +- 68.52 5 0 5 0 0.02 +- 0.01 5 4

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF04673 (5/5) Polyketide synthesis cyclase
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_30496 104.29 +- 51.71 2 0 0 0 0.11 +- 0.18 2 12

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13489 (2/2) Methyltransferase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_65 199.17 +- 91.62 5 0 0 0 0.05 +- 0.18 5 3

PF04149 (5/5) Domain of unknown function (DUF397)
PF13649 (4/5) Methyltransferase domain
PF13560 (3/5) Helix-turn-helix domain
precursor_jaccard_groups_30254 831.24 +- 728.76 2 0 2 2 0.06 +- 0.23 2 8

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF01061 (2/2) ABC-2 type transporter
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00160 (2/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_25875 169.40 +- 91.57 2 0 0 0 0.14 +- 0.17 2 25

TIGR03707 (2/2) polyphosphate kinase 2
TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF07729 (2/2) FCD domain
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01384 (2/2) Phosphate transporter family
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR03618 (1/2) PPOX class probable F420-dependent enzyme
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF03358 (1/2) NADPH-dependent FMN reductase
PF01638 (1/2) HxlR-like helix-turn-helix
PF01425 (1/2) Amidase
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00893 (1/2) Small Multidrug Resistance protein
precursor_jaccard_groups_41187 127.39 +- 21.46 2 0 0 0 0.12 +- 0.18 2 15

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13407 (2/2) Periplasmic binding protein domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04199 (2/2) Putative cyclase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF00575 (1/2) S1 RNA binding domain
precursor_jaccard_groups_21571 78.80 +- 44.78 2 0 2 0 0.20 +- 0.34 2 17

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03061 (2/2) Thioesterase superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF02057 (1/2) Glycosyl hydrolase family 59
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_21576 218.10 +- 64.15 3 0 0 0 0.05 +- 0.14 3 20

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01341 (3/3) aconitate hydratase 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01613 (3/3) Flavin reductase like domain
PF00694 (3/3) Aconitase C-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00330 (3/3) Aconitase family (aconitate hydratase)
PF00296 (3/3) Luciferase-like monooxygenase
PF00285 (3/3) Citrate synthase, C-terminal domain
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_4154 14.17 +- 3.10 4 0 0 0 0.14 +- 0.10 4 2

PF07995 (4/4) Glucose / Sorbosone dehydrogenase
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
precursor_jaccard_groups_29703 236.46 +- 153.54 2 0 2 2 0.02 +- 0.03 2 5

TIGR02438 (2/2) catechol 1,2-dioxygenase
PF04444 (2/2) Catechol dioxygenase N terminus
PF01494 (2/2) FAD binding domain
PF00775 (2/2) Dioxygenase
PF00733 (2/2) Asparagine synthase
precursor_jaccard_groups_25277 181.00 +- 77.00 2 0 0 0 0.01 +- 0.01 2 5

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF08306 (2/2) Glycosyl hydrolase family 98
PF02065 (2/2) Melibiase
PF00754 (2/2) F5/8 type C domain
precursor_jaccard_groups_38317 145.53 +- 112.47 2 0 0 0 0.05 +- 0.18 2 13

PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14588 (2/2) YjgF/chorismate_mutase-like, putative endoribonuclease
PF14336 (2/2) Domain of unknown function (DUF4392)
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07005 (2/2) Sugar-binding N-terminal domain
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF17203 (1/2) Single cache domain 3
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13188 (1/2) PAS domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01590 (1/2) GAF domain
precursor_jaccard_groups_1147 339.13 +- 0.00 3 0 0 0 0.03 +- 0.01 3 8

TIGR00574 (3/3) DNA ligase I, ATP-dependent (dnl1)
PF04679 (3/3) ATP dependent DNA ligase C terminal region
PF04675 (3/3) DNA ligase N terminus
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01380 (3/3) SIS domain
PF01068 (3/3) ATP dependent DNA ligase domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_jaccard_groups_15822 124.66 +- 0.85 2 0 0 0 0.05 +- 0.06 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF04542 (2/2) Sigma-70 region 2
PF04264 (2/2) YceI-like domain
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF00890 (1/2) FAD binding domain
precursor_jaccard_groups_44567 117.34 +- 48.52 2 0 2 0 0.03 +- 0.04 2 4

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_30671 27.36 +- 2.87 2 0 0 0 0.11 +- 0.06 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_28834 56.73 +- 9.21 2 0 0 0 0.09 +- 0.12 2 7

PF18029 (2/2) Glyoxalase-like domain
PF12867 (2/2) DinB superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_30675 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_30676 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_6889 65.61 +- 30.61 3 0 0 0 0.07 +- 0.06 3 8

TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/3) Glycosyl hydrolase family 92
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00553 (3/3) Cellulose binding domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/3) HAMP domain
PF00512 (2/3) His Kinase A (phospho-acceptor) domain
precursor_jaccard_groups_6881 2526.98 +- 1499.77 7 0 7 7 0.01 +- 0.01 7 8

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (7/7) Nitroreductase family
PF00296 (7/7) Luciferase-like monooxygenase
precursor_jaccard_groups_269 201.33 +- 242.34 42 0 8 42 0.06 +- 0.12 42 10

TIGR03859 (42/42) coenzyme PQQ biosynthesis protein PqqD
TIGR02109 (42/42) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (42/42) Iron-sulfur cluster-binding domain
PF05402 (42/42) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (42/42) Radical SAM superfamily
TIGR02111 (41/42) coenzyme PQQ biosynthesis protein C
PF03070 (41/42) TENA/THI-4/PQQC family
PF12706 (38/42) Beta-lactamase superfamily domain
TIGR02107 (35/42) coenzyme PQQ precursor peptide PqqA
PF07995 (35/42) Glucose / Sorbosone dehydrogenase
precursor_jaccard_groups_5852 1159.42 +- 342.97 8 0 0 0 0.04 +- 0.12 8 16

PF18565 (8/8) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (8/8) Domain of unknown function (DUF4982)
PF07859 (8/8) alpha/beta hydrolase fold
PF03737 (8/8) Aldolase/RraA
PF02837 (8/8) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (8/8) Glycosyl hydrolases family 2, TIM barrel domain
PF02775 (8/8) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01558 (8/8) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (8/8) Xylose isomerase-like TIM barrel
PF00703 (8/8) Glycosyl hydrolases family 2
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00440 (8/8) Bacterial regulatory proteins, tetR family
PF00155 (8/8) Aminotransferase class I and II
PF00756 (4/8) Putative esterase
precursor_jaccard_groups_30422 111.52 +- 3.19 2 0 0 0 0.03 +- 0.03 2 4

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF02566 (2/2) OsmC-like protein
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_5857 100.67 +- 33.24 4 0 1 0 0.14 +- 0.12 4 6

PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00942 (4/4) Cellulose binding domain
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
PF00722 (4/4) Glycosyl hydrolases family 16
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_29013 333.38 +- 53.62 2 0 0 0 0.09 +- 0.04 2 9

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_463 440.97 +- 404.03 2 0 0 0 0.04 +- 0.06 2 10

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF14033 (1/2) Protein of unknown function (DUF4246)
PF07591 (1/2) Pretoxin HINT domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01425 (1/2) Amidase
PF00482 (1/2) Type II secretion system (T2SS), protein F
precursor_jaccard_groups_16393 34.16 +- 4.43 2 0 0 0 0.15 +- 0.15 2 8

PF13796 (2/2) Putative sensor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07730 (2/2) Histidine kinase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_465 51.61 +- 21.50 5 0 1 0 0.06 +- 0.05 5 4

TIGR00476 (5/5) selenide, water dikinase
PF02769 (5/5) AIR synthase related protein, C-terminal domain
PF01471 (5/5) Putative peptidoglycan binding domain
PF00586 (5/5) AIR synthase related protein, N-terminal domain
precursor_jaccard_groups_37452 408.72 +- 371.28 2 0 2 0 0.08 +- 0.24 2 9

TIGR02262 (2/2) benzoate-CoA ligase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08031 (2/2) Berberine and berberine like
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_45562 204.45 +- 60.34 2 0 0 0 0.07 +- 0.04 2 11

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF07690 (2/2) Major Facilitator Superfamily
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00146 (2/2) NADH dehydrogenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_28548 1354.09 +- 64.09 2 0 0 0 0.01 +- 0.00 2 10

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF14832 (2/2) Putative oxalocrotonate tautomerase enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF00892 (2/2) EamA-like transporter family
PF00857 (2/2) Isochorismatase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_19848 517.33 +- 1.89 3 0 3 3 0.01 +- 0.00 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_19441 218.58 +- 5.07 3 0 3 0 0.02 +- 0.01 3 8

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13577 (3/3) SnoaL-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06902 (3/3) Divergent 4Fe-4S mono-cluster
PF04673 (3/3) Polyketide synthesis cyclase
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_20532 26.74 +- 1.00 2 0 0 0 0.15 +- 0.11 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_601 191.83 +- 148.64 14 0 0 0 0.02 +- 0.02 14 4

PF13649 (14/14) Methyltransferase domain
PF13280 (14/14) WYL domain
PF00300 (14/14) Histidine phosphatase superfamily (branch 1)
PF08279 (12/14) HTH domain
precursor_jaccard_groups_20536 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_44690 26.46 +- 1.39 2 0 0 0 0.11 +- 0.29 2 10

TIGR04267 (2/2) HEXXH motif domain
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF07075 (2/2) Protein of unknown function (DUF1343)
PF05547 (2/2) Immune inhibitor A peptidase M6
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_6939 39.50 +- 3.50 2 0 2 0 0.24 +- 0.16 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01443 (2/2) intein C-terminal splicing region
PF07591 (2/2) Pretoxin HINT domain
PF01804 (2/2) Penicillin amidase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
PF00501 (1/2) AMP-binding enzyme
precursor_jaccard_groups_7757 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_jaccard_groups_10490 16.84 +- 1.56 3 0 3 0 0.17 +- 0.21 3 9

PF13424 (3/3) Tetratricopeptide repeat
PF09997 (3/3) Predicted membrane protein (DUF2238)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF00348 (3/3) Polyprenyl synthetase
PF00144 (3/3) Beta-lactamase
PF00069 (3/3) Protein kinase domain
PF02342 (2/3) TerD domain
PF01987 (2/3) Mitochondrial biogenesis AIM24
PF00188 (2/3) Cysteine-rich secretory protein family
precursor_jaccard_groups_17915 91.34 +- 41.59 3 0 0 0 0.06 +- 0.13 3 9

PF13613 (3/3) Helix-turn-helix of DDE superfamily endonuclease
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13359 (3/3) DDE superfamily endonuclease
PF07690 (3/3) Major Facilitator Superfamily
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF13669 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13377 (2/3) Periplasmic binding protein-like domain
PF00356 (2/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_17912 163.15 +- 18.84 3 0 0 0 0.04 +- 0.03 3 5

PF13649 (3/3) Methyltransferase domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01047 (3/3) MarR family
PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_29233 211.09 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05593 (2/2) RHS Repeat
PF03527 (2/2) RHS protein
precursor_jaccard_groups_45100 53.36 +- 3.25 2 0 0 0 0.11 +- 0.12 2 12

TIGR01660 (2/2) nitrate reductase, beta subunit
TIGR01580 (2/2) nitrate reductase, alpha subunit
TIGR00684 (2/2) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (2/2) respiratory nitrate reductase, gamma subunit
PF14711 (2/2) Respiratory nitrate reductase beta C-terminal
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF02665 (2/2) Nitrate reductase gamma subunit
PF02613 (2/2) Nitrate reductase delta subunit
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_22019 239.74 +- 139.79 3 0 3 3 0.05 +- 0.04 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_26551 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_44368 160.63 +- 37.47 2 0 0 0 0.14 +- 0.22 2 20

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13464 (1/2) Domain of unknown function (DUF4115)
PF00271 (1/2) Helicase conserved C-terminal domain
PF00270 (1/2) DEAD/DEAH box helicase
PF00069 (1/2) Protein kinase domain
precursor_jaccard_groups_13164 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_jaccard_groups_3116 47.24 +- 30.43 4 0 4 0 0.18 +- 0.12 4 23

TIGR01733 (4/4) amino acid adenylation domain
PF16884 (4/4) N-terminal domain of oxidoreductase
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08659 (4/4) KR domain
PF04116 (4/4) Fatty acid hydroxylase superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01593 (4/4) Flavin containing amine oxidoreductase
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00107 (4/4) Zinc-binding dehydrogenase
PF07690 (3/4) Major Facilitator Superfamily
PF00067 (3/4) Cytochrome P450
PF17754 (2/4) MftR C-terminal domain
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
PF00440 (2/4) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_37238 182.28 +- 67.22 2 0 0 0 0.09 +- 0.06 2 10

TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF16347 (2/2) Domain of unknown function (DUF4976)
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF09084 (2/2) NMT1/THI5 like
PF04909 (2/2) Amidohydrolase
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_34228 141.31 +- 84.44 2 0 0 2 0.02 +- 0.05 2 5

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13570 (2/2) PQQ-like domain
PF13560 (2/2) Helix-turn-helix domain
PF13360 (2/2) PQQ-like domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_3448 725.24 +- 513.13 11 0 0 0 0.03 +- 0.04 11 8

PF13561 (11/11) Enoyl-(Acyl carrier protein) reductase
PF09084 (11/11) NMT1/THI5 like
PF03737 (11/11) Aldolase/RraA
PF03466 (11/11) LysR substrate binding domain
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF00294 (11/11) pfkB family carbohydrate kinase
PF00126 (11/11) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (11/11) ABC transporter
precursor_jaccard_groups_16408 131.88 +- 49.18 3 0 0 0 0.03 +- 0.02 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF02734 (3/3) DAK2 domain
PF02733 (3/3) Dak1 domain
PF00083 (3/3) Sugar (and other) transporter
TIGR02365 (2/3) dihydroxyacetone kinase, L subunit
precursor_jaccard_groups_2645 14.33 +- 1.43 2 0 0 0 0.14 +- 0.01 2 2

PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_15376 214.86 +- 44.62 3 0 0 0 0.08 +- 0.07 3 16

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03564 (3/3) F420-dependent oxidoreductase, MSMEG_4879 family
PF18029 (3/3) Glyoxalase-like domain
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07920 (3/3) Protein of unknown function (DUF1684)
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR01726 (2/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF02574 (2/3) Homocysteine S-methyltransferase
PF00497 (2/3) Bacterial extracellular solute-binding proteins, family 3
precursor_jaccard_groups_25126 121.33 +- 34.67 2 0 2 2 0.02 +- 0.01 2 2

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
precursor_jaccard_groups_5087 121.29 +- 102.40 7 0 0 0 0.04 +- 0.05 7 4

PF02838 (7/7) Glycosyl hydrolase family 20, domain 2
PF01120 (7/7) Alpha-L-fucosidase
PF00728 (7/7) Glycosyl hydrolase family 20, catalytic domain
PF00144 (7/7) Beta-lactamase
precursor_jaccard_groups_110 104.08 +- 48.18 2 0 0 0 0.19 +- 0.26 2 6

PF11774 (2/2) Lsr2
PF07730 (2/2) Histidine kinase
PF01061 (2/2) ABC-2 type transporter
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_10835 328.45 +- 257.44 4 0 0 0 0.03 +- 0.02 4 16

TIGR03804 (4/4) parallel beta-helix repeat
TIGR03641 (4/4) CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP
TIGR02593 (4/4) CRISPR-associated protein Cas5
TIGR02585 (4/4) CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP
TIGR01877 (4/4) CRISPR-associated endoribonuclease Cas6
TIGR01596 (4/4) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (4/4) CRISPR-associated helicase Cas3
TIGR01573 (4/4) CRISPR-associated endonuclease Cas2
PF18019 (4/4) HD domain
PF13229 (4/4) Right handed beta helix region
PF09827 (4/4) CRISPR associated protein Cas2
PF09704 (4/4) CRISPR-associated protein (Cas_Cas5)
PF01930 (4/4) Domain of unknown function DUF83
PF01881 (4/4) CRISPR associated protein Cas6
PF01867 (4/4) CRISPR associated protein Cas1
PF00270 (4/4) DEAD/DEAH box helicase
precursor_jaccard_groups_34829 294.61 +- 0.00 2 0 2 0 0.04 +- 0.10 2 16

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02254 (2/2) TrkA-N domain
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01323 (2/2) DSBA-like thioredoxin domain
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_jaccard_groups_15378 260.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 2

PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
precursor_jaccard_groups_40885 711.64 +- 133.36 2 0 0 0 0.01 +- 0.01 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF10935 (2/2) Protein of unknown function (DUF2637)
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_9438 220.23 +- 52.97 5 0 0 0 0.03 +- 0.03 5 10

PF09339 (5/5) IclR helix-turn-helix domain
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01614 (5/5) Bacterial transcriptional regulator
PF01425 (5/5) Amidase
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF02866 (4/5) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02775 (4/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00171 (4/5) Aldehyde dehydrogenase family
PF00056 (4/5) lactate/malate dehydrogenase, NAD binding domain
precursor_jaccard_groups_34791 18.20 +- 1.20 2 0 0 0 0.22 +- 0.34 2 8

PF13560 (2/2) Helix-turn-helix domain
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF04672 (2/2) S-adenosyl methyltransferase
PF04149 (2/2) Domain of unknown function (DUF397)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_12683 282.32 +- 186.77 2 0 0 2 0.03 +- 0.04 2 5

TIGR03930 (2/2) WXG100 family type VII secretion target
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_11831 30.48 +- 1.52 4 0 0 0 0.13 +- 0.14 4 7

PF14031 (4/4) Putative serine dehydratase domain
PF13309 (4/4) HTH domain
PF08348 (4/4) YheO-like PAS domain
PF07077 (4/4) Protein of unknown function (DUF1345)
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01168 (4/4) Alanine racemase, N-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_44960 63.98 +- 1.65 2 0 2 0 0.23 +- 0.31 2 11

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13478 (2/2) XdhC Rossmann domain
PF07883 (2/2) Cupin domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_44740 285.17 +- 3.72 2 0 0 0 0.03 +- 0.03 2 5

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF01425 (2/2) Amidase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF13546 (1/2) DDE superfamily endonuclease
PF01526 (1/2) Tn3 transposase DDE domain
precursor_jaccard_groups_32368 551.25 +- 228.75 2 0 0 0 0.03 +- 0.07 2 15

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF04444 (2/2) Catechol dioxygenase N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00501 (2/2) AMP-binding enzyme
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_3209 114.27 +- 17.27 3 0 3 0 0.06 +- 0.13 3 8

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
TIGR01534 (2/3) glyceraldehyde-3-phosphate dehydrogenase, type I
PF13450 (2/3) NAD(P)-binding Rossmann-like domain
PF02800 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (2/3) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_30108 10.22 +- 1.00 2 0 0 0 0.20 +- 0.07 2 2

PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_45526 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 2

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_34315 135.60 +- 89.11 2 0 0 0 0.12 +- 0.27 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12833 (2/2) Helix-turn-helix domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_287 385.92 +- 298.48 11 0 11 11 0.04 +- 0.13 11 7

TIGR04364 (11/11) methyltransferase, FxLD system
TIGR04363 (11/11) FxLD family lantipeptide
TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
PF01135 (11/11) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_jaccard_groups_3200 16.96 +- 1.51 7 0 7 0 0.17 +- 0.19 7 7

PF17765 (7/7) MmyB-like transcription regulator ligand binding domain
PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF13560 (7/7) Helix-turn-helix domain
PF01243 (7/7) Pyridoxamine 5'-phosphate oxidase
PF02797 (6/7) Chalcone and stilbene synthases, C-terminal domain
PF00195 (6/7) Chalcone and stilbene synthases, N-terminal domain
PF00067 (6/7) Cytochrome P450
precursor_jaccard_groups_2486 23.96 +- 15.47 5 0 0 0 0.18 +- 0.16 5 4

PF16157 (5/5) Domain of unknown function (DUF4865)
PF02126 (5/5) Phosphotriesterase family
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF07883 (4/5) Cupin domain
precursor_jaccard_groups_12889 148.59 +- 34.70 4 0 4 0 0.09 +- 0.18 4 12

PF13641 (4/4) Glycosyltransferase like family 2
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00925 (4/4) GTP cyclohydrolase II
PF00400 (4/4) WD domain, G-beta repeat
PF10823 (3/4) Protein of unknown function (DUF2568)
PF09335 (3/4) SNARE associated Golgi protein
PF01810 (3/4) LysE type translocator
PF00583 (3/4) Acetyltransferase (GNAT) family
PF00067 (3/4) Cytochrome P450
precursor_jaccard_groups_31478 50.30 +- 3.87 2 0 2 2 0.08 +- 0.05 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_43289 51.86 +- 4.58 2 0 2 0 0.08 +- 0.10 2 8

TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01794 (2/2) Ferric reductase like transmembrane component
PF01590 (2/2) GAF domain
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF00494 (2/2) Squalene/phytoene synthase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_23385 271.79 +- 83.75 3 0 0 0 0.14 +- 0.20 3 17

PF13508 (3/3) Acetyltransferase (GNAT) domain
PF11941 (3/3) Domain of unknown function (DUF3459)
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07705 (3/3) CARDB
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01756 (3/3) Acyl-CoA oxidase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00754 (3/3) F5/8 type C domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
PF00128 (3/3) Alpha amylase, catalytic domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_23382 40.84 +- 20.91 3 0 0 0 0.09 +- 0.11 3 6

TIGR01552 (3/3) prevent-host-death family protein
PF12277 (3/3) Protein of unknown function (DUF3618)
PF07332 (3/3) Putative Actinobacterial Holin-X, holin superfamily III
PF02604 (3/3) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01850 (3/3) PIN domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2791 20.14 +- 3.67 2 0 0 0 0.14 +- 0.03 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF04149 (2/2) Domain of unknown function (DUF397)
PF13560 (1/2) Helix-turn-helix domain
precursor_jaccard_groups_4819 97.26 +- 83.02 8 0 0 0 0.12 +- 0.27 8 6

TIGR03086 (8/8) TIGR03086 family protein
PF14534 (8/8) Domain of unknown function (DUF4440)
PF11716 (8/8) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08002 (8/8) Protein of unknown function (DUF1697)
PF02983 (8/8) Alpha-lytic protease prodomain
PF00089 (8/8) Trypsin
precursor_jaccard_groups_43351 31.72 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_43353 157.60 +- 16.51 2 0 2 0 0.08 +- 0.23 2 18

TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11706 (2/2) CGNR zinc finger
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07336 (2/2) Putative stress-induced transcription regulator
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02525 (2/2) Flavodoxin-like fold
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00067 (2/2) Cytochrome P450
PF00550 (1/2) Phosphopantetheine attachment site
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_7368 21.00 +- 4.97 3 0 2 0 0.10 +- 0.09 3 3

PF13564 (3/3) DoxX-like family
PF07883 (3/3) Cupin domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_4814 53.26 +- 10.52 4 0 0 0 0.18 +- 0.12 4 7

PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF08533 (3/4) Beta-galactosidase C-terminal domain
precursor_jaccard_groups_34556 77.83 +- 6.99 2 0 2 0 0.21 +- 0.32 2 22

TIGR01686 (2/2) FkbH domain
PF18605 (2/2) Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF11700 (2/2) Vacuole effluxer Atg22 like
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF03466 (2/2) LysR substrate binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_25728 410.49 +- 103.17 2 0 0 0 0.02 +- 0.05 2 10

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF12307 (2/2) Protein of unknown function (DUF3631)
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF00746 (2/2) LPXTG cell wall anchor motif
precursor_jaccard_groups_57 224.45 +- 191.07 59 4 48 33 0.07 +- 0.11 55 4

PF00069 (59/59) Protein kinase domain
PF00664 (58/59) ABC transporter transmembrane region
PF00005 (58/59) ABC transporter
PF05147 (33/59) Lanthionine synthetase C-like protein
precursor_jaccard_groups_52 64.95 +- 43.57 5 0 2 0 0.23 +- 0.20 5 9

PF14659 (5/5) Phage integrase, N-terminal SAM-like domain
PF12728 (5/5) Helix-turn-helix domain
PF10935 (5/5) Protein of unknown function (DUF2637)
PF05122 (5/5) Mobile element transfer protein
PF01580 (5/5) FtsK/SpoIIIE family
PF00589 (5/5) Phage integrase family
TIGR01764 (4/5) DNA binding domain, excisionase family
PF07702 (4/5) UTRA domain
PF00392 (4/5) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_13370 15.83 +- 2.49 3 0 0 0 0.19 +- 0.25 3 6

PF09350 (3/3) Domain of unknown function (DUF1992)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_39201 83.65 +- 5.65 2 0 0 0 0.04 +- 0.04 2 4

PF16757 (2/2) Alpha-L-fucosidase C-terminal domain
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01120 (2/2) Alpha-L-fucosidase
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
precursor_jaccard_groups_3064 113.02 +- 64.50 9 0 0 0 0.06 +- 0.09 9 6

PF14759 (9/9) Reductase C-terminal
PF07992 (9/9) Pyridine nucleotide-disulphide oxidoreductase
PF13370 (8/9) 4Fe-4S single cluster domain of Ferredoxin I
PF00903 (8/9) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF14016 (5/9) Protein of unknown function (DUF4232)
PF01557 (5/9) Fumarylacetoacetate (FAA) hydrolase family
precursor_jaccard_groups_58 60.20 +- 30.70 13 0 0 0 0.22 +- 0.30 13 7

TIGR03445 (13/13) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF07730 (13/13) Histidine kinase
PF02585 (13/13) GlcNAc-PI de-N-acetylase
PF00005 (12/13) ABC transporter
PF12698 (11/13) ABC-2 family transporter protein
PF00196 (11/13) Bacterial regulatory proteins, luxR family
PF00072 (11/13) Response regulator receiver domain
precursor_jaccard_groups_13379 166.14 +- 91.86 2 0 0 0 0.02 +- 0.01 2 3

PF07702 (2/2) UTRA domain
PF01590 (2/2) GAF domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_12569 388.50 +- 1.50 2 0 0 2 0.01 +- 0.00 2 6

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
precursor_jaccard_groups_6354 26.89 +- 5.88 7 0 0 0 0.16 +- 0.20 7 5

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF08044 (7/7) Domain of unknown function (DUF1707)
PF07690 (7/7) Major Facilitator Superfamily
PF00440 (7/7) Bacterial regulatory proteins, tetR family
PF00067 (7/7) Cytochrome P450
precursor_jaccard_groups_27942 160.58 +- 131.92 2 0 0 0 0.03 +- 0.04 2 3

PF02515 (2/2) CoA-transferase family III
PF00082 (2/2) Subtilase family
PF05425 (1/2) Copper resistance protein D
precursor_jaccard_groups_18142 72.47 +- 33.08 2 0 0 0 0.05 +- 0.04 2 6

PF12802 (2/2) MarR family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05368 (2/2) NmrA-like family
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF08332 (1/2) Calcium/calmodulin dependent protein kinase II association domain
precursor_jaccard_groups_18143 30.20 +- 1.31 2 0 0 0 0.07 +- 0.04 2 4

PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_14111 24.24 +- 7.21 4 0 0 0 0.22 +- 0.08 4 8

TIGR01234 (4/4) ribulokinase
PF13377 (4/4) Periplasmic binding protein-like domain
PF11762 (4/4) L-arabinose isomerase C-terminal domain
PF02782 (4/4) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (4/4) L-arabinose isomerase
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_18146 9.88 +- 1.70 3 0 0 0 0.21 +- 0.25 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_14661 70.71 +- 11.68 2 0 0 0 0.13 +- 0.13 2 5

PF14534 (2/2) Domain of unknown function (DUF4440)
PF08002 (2/2) Protein of unknown function (DUF1697)
PF01323 (2/2) DSBA-like thioredoxin domain
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_18498 224.28 +- 198.91 3 0 1 0 0.04 +- 0.05 3 4

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF02638 (3/3) Glycosyl hydrolase-like 10
PF01471 (3/3) Putative peptidoglycan binding domain
precursor_jaccard_groups_35978 17.62 +- 4.04 2 0 0 0 0.12 +- 0.11 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
precursor_jaccard_groups_32528 332.22 +- 72.22 2 0 0 0 0.01 +- 0.00 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF03746 (2/2) LamB/YcsF family
PF02682 (2/2) Carboxyltransferase domain, subdomain C and D
PF02626 (2/2) Carboxyltransferase domain, subdomain A and B
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_7544 157.42 +- 93.51 5 0 0 0 0.04 +- 0.08 5 5

PF06628 (5/5) Catalase-related immune-responsive
PF01475 (5/5) Ferric uptake regulator family
PF00248 (5/5) Aldo/keto reductase family
PF00199 (5/5) Catalase
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_9651 38.89 +- 9.46 4 0 0 0 0.08 +- 0.09 4 6

TIGR03696 (4/4) RHS repeat-associated core domain
TIGR01643 (4/4) YD repeat (two copies)
TIGR00778 (4/4) alkylhydroperoxidase AhpD family core domain
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF05593 (4/4) RHS Repeat
PF02627 (4/4) Carboxymuconolactone decarboxylase family
precursor_jaccard_groups_22271 338.62 +- 48.38 2 0 0 0 0.01 +- 0.00 2 2

PF07690 (2/2) Major Facilitator Superfamily
PF07519 (2/2) Tannase and feruloyl esterase
precursor_jaccard_groups_14069 1974.26 +- 999.08 3 0 3 3 0.01 +- 0.04 3 11

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (3/3) ABC-2 type transporter
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR03882 (2/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00881 (2/3) Nitroreductase family
precursor_jaccard_groups_35370 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_14064 579.93 +- 757.51 3 0 3 1 0.03 +- 0.04 3 9

TIGR01733 (3/3) amino acid adenylation domain
TIGR00709 (3/3) 2,4-diaminobutyrate 4-transaminase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00202 (3/3) Aminotransferase class-III
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_jaccard_groups_14061 37.31 +- 5.54 3 0 0 0 0.11 +- 0.10 3 5

PF06723 (3/3) MreB/Mbl protein
PF03060 (3/3) Nitronate monooxygenase
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_11617 680.00 +- 57.77 4 0 4 4 0.01 +- 0.00 4 11

TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF13537 (4/4) Glutamine amidotransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05114 (4/4) Protein of unknown function (DUF692)
PF04303 (4/4) PrpF protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF01979 (4/4) Amidohydrolase family
PF00881 (4/4) Nitroreductase family
PF00733 (4/4) Asparagine synthase
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (3/4) Acyl-CoA dehydrogenase, middle domain
precursor_jaccard_groups_11614 19.54 +- 2.52 4 0 0 0 0.19 +- 0.29 4 8

TIGR02980 (4/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14087 (4/4) Domain of unknown function (DUF4267)
PF13649 (4/4) Methyltransferase domain
PF04545 (4/4) Sigma-70, region 4
PF04542 (4/4) Sigma-70 region 2
PF04539 (4/4) Sigma-70 region 3
PF01590 (4/4) GAF domain
PF00583 (3/4) Acetyltransferase (GNAT) family
precursor_jaccard_groups_11611 204.12 +- 86.97 4 0 4 0 0.09 +- 0.13 4 17

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10862 (4/4) FcoT-like thioesterase domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_6768 32.76 +- 5.45 5 0 0 0 0.16 +- 0.09 5 7

PF07690 (5/5) Major Facilitator Superfamily
PF04131 (5/5) Putative N-acetylmannosamine-6-phosphate epimerase
PF02909 (5/5) Tetracyclin repressor-like, C-terminal domain
PF01494 (5/5) FAD binding domain
PF00701 (5/5) Dihydrodipicolinate synthetase family
PF00480 (5/5) ROK family
PF00440 (5/5) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_2425 38.01 +- 2.35 2 0 0 0 0.21 +- 0.23 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF01427 (2/2) D-ala-D-ala dipeptidase
precursor_jaccard_groups_35685 126.63 +- 34.90 2 0 2 0 0.12 +- 0.15 2 7

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_32321 162.00 +- 33.00 2 0 0 0 0.02 +- 0.01 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_11532 28.63 +- 3.51 4 0 4 0 0.15 +- 0.25 4 6

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00501 (4/4) AMP-binding enzyme
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_jaccard_groups_34854 259.00 +- 1.00 2 0 0 2 0.01 +- 0.00 2 4

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
precursor_jaccard_groups_15621 381.94 +- 45.60 3 0 0 0 0.01 +- 0.01 3 8

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF07690 (3/3) Major Facilitator Superfamily
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_33235 118.89 +- 102.25 2 0 2 0 0.06 +- 0.18 2 4

PF17195 (2/2) Protein of unknown function (DUF5132)
PF12697 (2/2) Alpha/beta hydrolase family
PF05960 (2/2) Bacterial protein of unknown function (DUF885)
PF00975 (2/2) Thioesterase domain
precursor_jaccard_groups_39733 203.61 +- 44.72 2 0 0 0 0.06 +- 0.01 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6780 259.00 +- 1.00 2 0 2 2 0.01 +- 0.00 2 3

PF05147 (2/2) Lanthionine synthetase C-like protein
PF04055 (2/2) Radical SAM superfamily
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_33236 36.86 +- 0.00 2 0 2 0 0.05 +- 0.08 2 2

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_7786 298.54 +- 60.97 6 0 0 0 0.03 +- 0.02 6 7

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF08666 (6/6) SAF domain
PF07811 (6/6) TadE-like protein
PF03704 (6/6) Bacterial transcriptional activator domain
PF01476 (6/6) LysM domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_jaccard_groups_42390 20.26 +- 1.65 2 0 0 0 0.15 +- 0.23 2 5

PF13377 (2/2) Periplasmic binding protein-like domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (2/2) Cellulose binding domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_13599 106.18 +- 2.15 2 0 2 0 0.05 +- 0.00 2 9

TIGR01060 (2/2) phosphopyruvate hydratase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF03952 (2/2) Enolase, N-terminal domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00113 (2/2) Enolase, C-terminal TIM barrel domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_2331 262.34 +- 76.06 14 0 2 0 0.01 +- 0.01 14 4

PF03412 (14/14) Peptidase C39 family
PF00664 (14/14) ABC transporter transmembrane region
PF00535 (14/14) Glycosyl transferase family 2
PF00005 (14/14) ABC transporter
precursor_jaccard_groups_2337 810.60 +- 160.00 8 0 8 0 0.02 +- 0.10 8 27

TIGR01850 (8/8) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (8/8) amino acid adenylation domain
TIGR00761 (8/8) acetylglutamate kinase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF01546 (8/8) Peptidase family M20/M25/M40
PF01118 (8/8) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (8/8) Amino acid kinase family
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
TIGR01902 (6/8) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF13561 (6/8) Enoyl-(Acyl carrier protein) reductase
PF08443 (6/8) RimK-like ATP-grasp domain
PF02774 (6/8) Semialdehyde dehydrogenase, dimerisation domain
TIGR01206 (5/8) lysine biosynthesis protein LysW
TIGR00768 (5/8) alpha-L-glutamate ligase, RimK family
PF16197 (5/8) Ketoacyl-synthetase C-terminal extension
PF08659 (5/8) KR domain
PF07993 (5/8) Male sterility protein
PF03621 (5/8) MbtH-like protein
PF02801 (5/8) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/8) Acyl transferase domain
PF00109 (5/8) Beta-ketoacyl synthase, N-terminal domain
PF14399 (4/8) Butirosin biosynthesis protein H, N-terminal
PF02771 (4/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/8) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/8) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_8879 285.47 +- 50.52 5 0 0 0 0.02 +- 0.03 5 9

TIGR01324 (5/5) cystathionine beta-lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF02786 (5/5) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01053 (5/5) Cys/Met metabolism PLP-dependent enzyme
PF00581 (5/5) Rhodanese-like domain
PF13229 (3/5) Right handed beta helix region
PF02655 (3/5) ATP-grasp domain
precursor_jaccard_groups_44379 172.67 +- 0.67 2 0 2 0 0.01 +- 0.00 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_1833 302.48 +- 82.04 14 0 14 14 0.01 +- 0.01 14 3

PF13471 (14/14) Transglutaminase-like superfamily
PF13302 (14/14) Acetyltransferase (GNAT) domain
PF00733 (14/14) Asparagine synthase
precursor_jaccard_groups_1520 76.99 +- 36.20 11 0 9 0 0.19 +- 0.13 11 11

PF13385 (11/11) Concanavalin A-like lectin/glucanases superfamily
PF08386 (11/11) TAP-like protein
PF07691 (11/11) PA14 domain
PF02837 (11/11) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (11/11) Glycosyl hydrolases family 2
PF00561 (11/11) alpha/beta hydrolase fold
PF13407 (10/11) Periplasmic binding protein domain
PF02653 (10/11) Branched-chain amino acid transport system / permease component
PF00005 (10/11) ABC transporter
PF13377 (9/11) Periplasmic binding protein-like domain
PF00356 (9/11) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_16780 636.32 +- 221.68 2 0 0 0 0.02 +- 0.03 2 3

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_1839 830.60 +- 180.60 2 0 1 2 0.04 +- 0.04 2 23

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF13649 (1/2) Methyltransferase domain
PF02875 (1/2) Mur ligase family, glutamate ligase domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (1/2) GAF domain
PF01427 (1/2) D-ala-D-ala dipeptidase
PF00723 (1/2) Glycosyl hydrolases family 15
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_1529 4937.06 +- 1952.35 24 0 24 24 0.01 +- 0.05 24 10

TIGR03882 (24/24) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (24/24) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (24/24) Lantibiotic biosynthesis dehydratase C-term
PF02624 (24/24) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (24/24) Nitroreductase family
PF00005 (24/24) ABC transporter
PF12698 (15/24) ABC-2 family transporter protein
TIGR03891 (13/24) thiopeptide-type bacteriocin biosynthesis domain
PF05402 (13/24) Coenzyme PQQ synthesis protein D (PqqD)
PF13601 (12/24) Winged helix DNA-binding domain
precursor_jaccard_groups_33125 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 8

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (2/2) GAF domain
PF12450 (2/2) von Willebrand factor
PF12034 (2/2) Domain of unknown function (DUF3520)
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03704 (2/2) Bacterial transcriptional activator domain
PF00092 (2/2) von Willebrand factor type A domain
precursor_jaccard_groups_15289 1452.30 +- 801.37 3 0 0 0 0.03 +- 0.09 3 9

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06259 (3/3) Alpha/beta hydrolase
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_24917 1186.67 +- 103.33 2 0 0 0 0.01 +- 0.00 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF14310 (2/2) Fibronectin type III-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_45316 433.15 +- 43.15 2 0 2 0 0.02 +- 0.02 2 18

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14435 (2/2) SUKH-4 immunity protein
PF13462 (2/2) Thioredoxin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_541 111.39 +- 89.74 46 0 16 46 0.06 +- 0.16 46 4

PF07690 (46/46) Major Facilitator Superfamily
PF04055 (46/46) Radical SAM superfamily
PF02897 (46/46) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (46/46) Prolyl oligopeptidase family
precursor_jaccard_groups_32748 74.55 +- 19.27 2 0 0 2 0.04 +- 0.05 2 7

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF03547 (2/2) Membrane transport protein
PF00892 (2/2) EamA-like transporter family
PF00881 (2/2) Nitroreductase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_18286 12.71 +- 4.49 2 0 0 0 0.18 +- 0.17 2 3

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_2934 259.00 +- 1.00 4 0 0 0 0.01 +- 0.00 4 2

PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF01814 (4/4) Hemerythrin HHE cation binding domain
precursor_jaccard_groups_36409 408.32 +- 127.52 2 0 0 0 0.02 +- 0.02 2 10

TIGR01136 (2/2) cysteine synthase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01361 (2/2) Tautomerase enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_11289 419.05 +- 309.92 4 0 2 0 0.07 +- 0.06 4 11

TIGR01428 (4/4) haloacid dehalogenase, type II
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
TIGR01726 (2/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13416 (2/4) Bacterial extracellular solute-binding protein
PF08402 (2/4) TOBE domain
PF00497 (2/4) Bacterial extracellular solute-binding proteins, family 3
precursor_jaccard_groups_38482 255.00 +- 135.00 2 0 0 0 0.02 +- 0.02 2 4

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01494 (2/2) FAD binding domain
PF00797 (2/2) N-acetyltransferase
precursor_jaccard_groups_16268 34.67 +- 0.00 2 0 2 0 0.06 +- 0.03 2 2

PF03745 (2/2) Domain of unknown function (DUF309)
PF01636 (2/2) Phosphotransferase enzyme family
precursor_jaccard_groups_22146 462.27 +- 130.14 3 0 0 0 0.01 +- 0.01 3 9

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF00487 (3/3) Fatty acid desaturase
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_22417 219.78 +- 159.77 3 0 3 0 0.06 +- 0.09 3 8

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03919 (3/3) type VII secretion protein EccB
PF13560 (3/3) Helix-turn-helix domain
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF04149 (3/3) Domain of unknown function (DUF397)
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_22415 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_jaccard_groups_6433 20.13 +- 3.02 3 0 0 0 0.10 +- 0.09 3 2

PF13508 (3/3) Acetyltransferase (GNAT) domain
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_jaccard_groups_8277 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_18035 361.61 +- 108.54 3 0 0 0 0.02 +- 0.01 3 8

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF06496 (3/3) Protein of unknown function (DUF1097)
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit
precursor_jaccard_groups_18036 10.58 +- 0.26 2 0 0 0 0.19 +- 0.06 2 4

TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13202 (2/2) EF hand
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
precursor_jaccard_groups_10130 65.41 +- 17.32 2 0 0 0 0.15 +- 0.14 2 7

PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF02449 (2/2) Beta-galactosidase
PF01670 (2/2) Glycosyl hydrolase family 12
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_857 112.88 +- 16.12 2 0 0 0 0.02 +- 0.02 2 2

PF13649 (2/2) Methyltransferase domain
PF05685 (2/2) Putative restriction endonuclease
precursor_jaccard_groups_851 230.98 +- 125.35 4 0 4 4 0.06 +- 0.13 4 4

PF05147 (4/4) Lanthionine synthetase C-like protein
PF00069 (4/4) Protein kinase domain
PF13302 (3/4) Acetyltransferase (GNAT) domain
PF00294 (2/4) pfkB family carbohydrate kinase
precursor_jaccard_groups_6236 87.31 +- 58.20 6 0 0 0 0.04 +- 0.05 6 2

TIGR03930 (6/6) WXG100 family type VII secretion target
PF06013 (6/6) Proteins of 100 residues with WXG
precursor_jaccard_groups_6542 412.80 +- 103.20 2 0 2 2 0.01 +- 0.00 2 2

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_32705 482.86 +- 37.14 2 0 0 0 0.02 +- 0.01 2 8

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6545 63.00 +- 23.00 4 0 0 0 0.04 +- 0.02 4 2

PF01757 (4/4) Acyltransferase family
PF00106 (4/4) short chain dehydrogenase
precursor_jaccard_groups_1783 35.70 +- 15.84 2 0 0 0 0.09 +- 0.13 2 3

PF00877 (2/2) NlpC/P60 family
PF11203 (1/2) Putative type VII ESX secretion system translocon, EccE
PF00535 (1/2) Glycosyl transferase family 2
precursor_jaccard_groups_11445 54.61 +- 22.32 3 0 0 0 0.06 +- 0.07 3 4

PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00583 (2/3) Acetyltransferase (GNAT) family
precursor_jaccard_groups_14805 27.10 +- 6.92 3 0 0 0 0.08 +- 0.07 3 3

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_11440 75.50 +- 106.52 4 0 0 0 0.11 +- 0.19 4 2

PF02779 (4/4) Transketolase, pyrimidine binding domain
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
precursor_jaccard_groups_29835 26.74 +- 5.51 2 0 0 0 0.12 +- 0.18 2 6

TIGR03567 (2/2) FMN reductase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF00962 (2/2) Adenosine/AMP deaminase
PF00720 (2/2) Subtilisin inhibitor-like
precursor_jaccard_groups_35991 1078.07 +- 82.93 2 0 2 0 0.01 +- 0.00 2 21

TIGR04171 (2/2) ribonucleoside-diphosphate reductase, class 1b, beta subunit
TIGR04170 (2/2) ribonucleoside-diphosphate reductase, class 1b, alpha subunit
TIGR02124 (2/2) hydrogenase expression/formation protein HypE
TIGR00143 (2/2) carbamoyltransferase HypF
PF17788 (2/2) HypF Kae1-like domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF08343 (2/2) Ribonucleotide reductase N-terminal
PF07690 (2/2) Major Facilitator Superfamily
PF07503 (2/2) HypF finger
PF05977 (2/2) Transmembrane secretion effector
PF04167 (2/2) Protein of unknown function (DUF402)
PF02867 (2/2) Ribonucleotide reductase, barrel domain
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01300 (2/2) Telomere recombination
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00857 (2/2) Isochorismatase family
PF00708 (2/2) Acylphosphatase
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00317 (2/2) Ribonucleotide reductase, all-alpha domain
PF00268 (2/2) Ribonucleotide reductase, small chain
precursor_jaccard_groups_33341 25.06 +- 0.10 2 0 0 0 0.20 +- 0.36 2 9

TIGR00485 (2/2) translation elongation factor Tu
PF13828 (2/2) Domain of unknown function (DUF4190)
PF09913 (2/2) Predicted membrane protein (DUF2142)
PF08044 (2/2) Domain of unknown function (DUF1707)
PF04138 (2/2) GtrA-like protein
PF03144 (2/2) Elongation factor Tu domain 2
PF03143 (2/2) Elongation factor Tu C-terminal domain
PF00535 (2/2) Glycosyl transferase family 2
PF00009 (2/2) Elongation factor Tu GTP binding domain
precursor_jaccard_groups_33343 172.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 2

PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF03713 (2/2) Domain of unknown function (DUF305)
precursor_jaccard_groups_12398 342.72 +- 122.82 4 0 0 0 0.03 +- 0.03 4 8

PF14525 (4/4) AraC-binding-like domain
PF12833 (4/4) Helix-turn-helix domain
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF02909 (4/4) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_jaccard_groups_15754 10.38 +- 1.09 2 0 1 0 0.20 +- 0.02 2 12

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13478 (2/2) XdhC Rossmann domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
precursor_jaccard_groups_29953 39.09 +- 3.91 2 0 0 0 0.08 +- 0.01 2 5

PF16884 (2/2) N-terminal domain of oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_7969 31.72 +- 11.32 6 0 0 0 0.11 +- 0.13 6 7

PF18011 (6/6) C-terminal domain found in long catalases
PF13520 (6/6) Amino acid permease
PF13439 (6/6) Glycosyltransferase Family 4
PF06628 (6/6) Catalase-related immune-responsive
PF02709 (6/6) N-terminal domain of galactosyltransferase
PF00534 (6/6) Glycosyl transferases group 1
PF00199 (6/6) Catalase
precursor_jaccard_groups_27640 23.46 +- 3.14 2 0 0 2 0.17 +- 0.33 2 5

PF04972 (2/2) BON domain
PF00881 (2/2) Nitroreductase family
PF00571 (2/2) CBS domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_39847 129.26 +- 48.01 2 0 0 0 0.09 +- 0.06 2 8

PF13187 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
precursor_jaccard_groups_19458 483.60 +- 137.88 3 0 0 0 0.05 +- 0.05 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_44236 350.75 +- 107.92 2 0 0 0 0.01 +- 0.01 2 8

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_12403 133.50 +- 84.85 3 0 0 0 0.08 +- 0.20 3 4

PF07690 (3/3) Major Facilitator Superfamily
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_22703 632.96 +- 689.98 3 0 0 0 0.09 +- 0.20 3 9

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF05345 (3/3) Putative Ig domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (3/3) Proprotein convertase P-domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00664 (3/3) ABC transporter transmembrane region
PF00656 (3/3) Caspase domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_7966 789.47 +- 163.41 5 0 5 5 0.01 +- 0.02 5 9

TIGR04085 (5/5) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF08241 (5/5) Methyltransferase domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF01980 (5/5) tRNA-methyltransferase O
PF01494 (5/5) FAD binding domain
PF17920 (4/5) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/5) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_20853 1233.71 +- 550.62 3 0 0 0 0.01 +- 0.00 3 4

PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_jaccard_groups_19036 133.74 +- 6.33 3 0 0 0 0.13 +- 0.29 3 12

PF16925 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14534 (3/3) Domain of unknown function (DUF4440)
PF13602 (3/3) Zinc-binding dehydrogenase
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13160 (3/3) Protein of unknown function (DUF3995)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF05195 (3/3) Aminopeptidase P, N-terminal domain
PF04951 (3/3) D-aminopeptidase
PF00557 (3/3) Metallopeptidase family M24
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_1657 350.90 +- 99.07 8 0 0 0 0.01 +- 0.01 8 5

PF03007 (8/8) Wax ester synthase-like Acyl-CoA acyltransferase domain
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF06974 (5/8) Protein of unknown function (DUF1298)
precursor_jaccard_groups_1656 85.50 +- 32.32 15 0 3 0 0.05 +- 0.05 15 5

PF11387 (15/15) Protein of unknown function (DUF2795)
PF02133 (15/15) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00857 (15/15) Isochorismatase family
PF07179 (14/15) SseB protein N-terminal domain
PF12706 (12/15) Beta-lactamase superfamily domain
precursor_jaccard_groups_1302 251.89 +- 204.05 28 0 0 28 0.03 +- 0.04 28 6

TIGR03882 (28/28) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (28/28) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (28/28) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (28/28) Nitroreductase family
PF00664 (28/28) ABC transporter transmembrane region
PF00005 (28/28) ABC transporter
precursor_jaccard_groups_1652 16.92 +- 2.81 20 0 20 0 0.18 +- 0.20 20 4

PF11991 (20/20) Tryptophan dimethylallyltransferase
PF05331 (20/20) Protein of unknown function (DUF742)
PF03259 (20/20) Roadblock/LC7 domain
PF03029 (20/20) Conserved hypothetical ATP binding protein
precursor_jaccard_groups_18990 518.00 +- 2.00 2 0 0 2 0.01 +- 0.00 2 9

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF05977 (2/2) Transmembrane secretion effector
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_36535 111.54 +- 7.54 2 0 0 2 0.03 +- 0.03 2 4

PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF02223 (2/2) Thymidylate kinase
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_16891 42.59 +- 22.93 2 0 0 0 0.13 +- 0.23 2 6

PF10011 (2/2) Predicted membrane protein (DUF2254)
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_18924 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain
precursor_jaccard_groups_9876 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily
precursor_jaccard_groups_42820 304.77 +- 44.77 2 0 0 0 0.02 +- 0.01 2 6

PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01935 (2/2) Helicase HerA, central domain
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_jaccard_groups_5141 519.99 +- 158.48 8 0 8 0 0.02 +- 0.01 8 13

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (8/8) amino acid adenylation domain
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF02655 (8/8) ATP-grasp domain
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00296 (8/8) Luciferase-like monooxygenase
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_42826 601.71 +- 122.57 2 0 0 2 0.01 +- 0.00 2 11

PF16864 (2/2) Dimerisation domain
PF13649 (2/2) Methyltransferase domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00891 (2/2) O-methyltransferase domain
PF00670 (2/2) S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_12574 281.99 +- 177.86 4 0 4 0 0.06 +- 0.20 4 4

PF06500 (4/4) Alpha/beta hydrolase of unknown function (DUF1100)
PF01494 (4/4) FAD binding domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00198 (4/4) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_jaccard_groups_12573 171.19 +- 56.94 4 0 0 0 0.01 +- 0.01 4 4

TIGR00447 (4/4) aminoacyl-tRNA hydrolase
PF11303 (4/4) Protein of unknown function (DUF3105)
PF03713 (4/4) Domain of unknown function (DUF305)
PF01195 (4/4) Peptidyl-tRNA hydrolase
precursor_jaccard_groups_37595 232.20 +- 77.40 2 0 0 0 0.01 +- 0.01 2 4

PF04266 (2/2) ASCH domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_37265 151.17 +- 22.17 2 0 0 0 0.03 +- 0.03 2 8

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07702 (2/2) UTRA domain
PF03747 (2/2) ADP-ribosylglycohydrolase
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF02133 (1/2) Permease for cytosine/purines, uracil, thiamine, allantoin
precursor_jaccard_groups_38263 209.21 +- 56.32 2 0 2 0 0.06 +- 0.12 2 12

PF13407 (2/2) Periplasmic binding protein domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01263 (2/2) Aldose 1-epimerase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00005 (2/2) ABC transporter
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
precursor_jaccard_groups_41122 614.31 +- 165.69 2 0 0 0 0.02 +- 0.07 2 13

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF13649 (2/2) Methyltransferase domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07398 (2/2) MDMPI C-terminal domain
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00303 (2/2) Thymidylate synthase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (1/2) Acyl-CoA oxidase
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_41127 452.75 +- 127.75 2 0 0 2 0.01 +- 0.00 2 7

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF10014 (2/2) 2OG-Fe dioxygenase
PF07690 (2/2) Major Facilitator Superfamily
PF04828 (2/2) Glutathione-dependent formaldehyde-activating enzyme
PF04055 (2/2) Radical SAM superfamily
PF00487 (2/2) Fatty acid desaturase
precursor_jaccard_groups_22568 138.21 +- 87.51 3 0 3 3 0.12 +- 0.24 3 12

TIGR04188 (3/3) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (3/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (3/3) putative ATP-grasp target RiPP
PF14408 (3/3) Ribosomally synthesised peptide in actinomycetes
PF13581 (3/3) Histidine kinase-like ATPase domain
PF07969 (3/3) Amidohydrolase family
PF07702 (3/3) UTRA domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01032 (3/3) FecCD transport family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_22561 382.91 +- 195.96 3 0 0 0 0.03 +- 0.04 3 9

PF09339 (3/3) IclR helix-turn-helix domain
PF03466 (3/3) LysR substrate binding domain
PF01614 (3/3) Bacterial transcriptional regulator
PF01522 (3/3) Polysaccharide deacetylase
PF00561 (3/3) alpha/beta hydrolase fold
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family
PF02776 (2/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
precursor_jaccard_groups_22564 76.17 +- 27.03 2 0 2 0 0.03 +- 0.03 2 6

PF14525 (2/2) AraC-binding-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12833 (2/2) Helix-turn-helix domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_21892 447.68 +- 277.08 3 0 2 0 0.03 +- 0.03 3 6

PF05426 (3/3) Alginate lyase
PF05345 (3/3) Putative Ig domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00295 (3/3) Glycosyl hydrolases family 28
PF00135 (2/3) Carboxylesterase family
precursor_jaccard_groups_18857 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF04321 (2/2) RmlD substrate binding domain
PF02719 (2/2) Polysaccharide biosynthesis protein
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_8454 27.10 +- 9.02 3 0 3 0 0.19 +- 0.30 3 8

PF13410 (3/3) Glutathione S-transferase, C-terminal domain
PF13409 (3/3) Glutathione S-transferase, N-terminal domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF03422 (3/3) Carbohydrate binding module (family 6)
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00722 (3/3) Glycosyl hydrolases family 16
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF13230 (2/3) Glutamine amidotransferases class-II
precursor_jaccard_groups_4143 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_4140 202.33 +- 316.65 6 0 0 0 0.15 +- 0.33 6 8

PF14029 (6/6) Protein of unknown function (DUF4244)
PF00482 (6/6) Type II secretion system (T2SS), protein F
TIGR03819 (5/6) helicase/secretion neighborhood ATPase
TIGR03816 (5/6) helicase/secretion neighborhood TadE-like protein
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF00437 (5/6) Type II/IV secretion system protein
TIGR03815 (4/6) helicase/secretion neighborhood CpaE-like protein
PF01656 (3/6) CobQ/CobB/MinD/ParA nucleotide binding domain
precursor_jaccard_groups_8450 472.70 +- 171.61 5 0 3 0 0.02 +- 0.01 5 8

PF13416 (5/5) Bacterial extracellular solute-binding protein
PF09339 (5/5) IclR helix-turn-helix domain
PF05199 (5/5) GMC oxidoreductase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00732 (5/5) GMC oxidoreductase
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00480 (5/5) ROK family
PF00383 (5/5) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_36628 120.40 +- 34.40 2 0 0 2 0.02 +- 0.02 2 5

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF03995 (2/2) Peptidase inhibitor family I36
PF00733 (2/2) Asparagine synthase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_25869 263.12 +- 19.07 2 0 0 0 0.05 +- 0.06 2 11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF13237 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01061 (2/2) ABC-2 type transporter
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4145 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_25867 223.36 +- 10.64 2 0 0 0 0.04 +- 0.04 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF08532 (1/2) Beta-galactosidase trimerisation domain
PF02449 (1/2) Beta-galactosidase
precursor_jaccard_groups_29710 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_9900 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18014 (2/2) Acetyltransferase (GNAT) domain
PF03777 (2/2) ChpA-C
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_12088 34.55 +- 4.24 4 0 0 0 0.09 +- 0.03 4 7

PF13377 (4/4) Periplasmic binding protein-like domain
PF13343 (4/4) Bacterial extracellular solute-binding protein
PF12802 (4/4) MarR family
PF12680 (4/4) SnoaL-like domain
PF01323 (4/4) DSBA-like thioredoxin domain
PF00753 (4/4) Metallo-beta-lactamase superfamily
PF00356 (4/4) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_44519 18.91 +- 0.00 2 0 0 0 0.11 +- 0.08 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07681 (2/2) DoxX
precursor_jaccard_groups_30662 582.00 +- 192.00 2 0 0 0 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_30661 301.01 +- 159.70 2 0 0 0 0.02 +- 0.02 2 7

PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_16270 29.33 +- 4.05 3 0 0 0 0.10 +- 0.11 3 5

PF13517 (3/3) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF12867 (3/3) DinB superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF00089 (3/3) Trypsin
precursor_jaccard_groups_26287 105.74 +- 24.26 2 0 0 0 0.03 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_26284 517.14 +- 77.14 2 0 0 0 0.01 +- 0.01 2 7

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (2/2) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_7775 94.48 +- 13.27 6 0 0 0 0.10 +- 0.05 6 8

PF16353 (6/6) Domain of unknown function(DUF4981)
PF13416 (6/6) Bacterial extracellular solute-binding protein
PF02929 (6/6) Beta galactosidase small chain
PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (6/6) Glycosyl hydrolases family 2
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_jaccard_groups_20142 129.47 +- 98.14 3 0 0 0 0.04 +- 0.06 3 1

PF01810 (3/3) LysE type translocator
precursor_jaccard_groups_273 68.04 +- 58.94 24 0 3 0 0.11 +- 0.15 24 4

PF00067 (24/24) Cytochrome P450
PF13370 (23/24) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (13/24) Pyridine nucleotide-disulphide oxidoreductase
PF00171 (13/24) Aldehyde dehydrogenase family
precursor_jaccard_groups_20631 488.44 +- 38.97 3 0 3 3 0.01 +- 0.00 3 7

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (3/3) luciferase family oxidoreductase, group 1
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_276 21.00 +- 9.59 26 0 3 0 0.18 +- 0.27 26 12

PF06386 (26/26) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (26/26) Gas vesicle synthesis protein GvpO
PF05121 (26/26) Gas vesicle protein K
PF05120 (26/26) Gas vesicle protein G
PF03364 (26/26) Polyketide cyclase / dehydrase and lipid transport
PF00741 (26/26) Gas vesicle protein
PF17657 (23/26) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (23/26) Helix-hairpin-helix motif
PF07733 (23/26) Bacterial DNA polymerase III alpha NTPase domain
PF02811 (23/26) PHP domain
TIGR00594 (22/26) DNA polymerase III, alpha subunit
PF00817 (22/26) impB/mucB/samB family
precursor_jaccard_groups_17675 162.70 +- 50.89 3 0 3 0 0.05 +- 0.06 3 7

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03466 (3/3) LysR substrate binding domain
PF01361 (3/3) Tautomerase enzyme
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_25468 293.18 +- 35.18 2 0 0 0 0.01 +- 0.00 2 9

TIGR02170 (2/2) thymidylate synthase, flavin-dependent
TIGR00730 (2/2) TIGR00730 family protein
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (2/2) ATP-grasp domain
PF03641 (2/2) Possible lysine decarboxylase
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02511 (2/2) Thymidylate synthase complementing protein
PF00860 (2/2) Permease family
precursor_jaccard_groups_17670 26.58 +- 5.62 3 0 0 0 0.08 +- 0.07 3 4

TIGR00369 (3/3) uncharacterized domain 1
PF11695 (3/3) Domain of unknown function (DUF3291)
PF03061 (3/3) Thioesterase superfamily
PF01638 (3/3) HxlR-like helix-turn-helix
precursor_jaccard_groups_478 39.19 +- 11.66 6 0 0 0 0.12 +- 0.21 6 7

TIGR00710 (6/6) drug resistance transporter, Bcr/CflA subfamily
PF07690 (6/6) Major Facilitator Superfamily
PF03466 (6/6) LysR substrate binding domain
PF02826 (6/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01361 (6/6) Tautomerase enzyme
PF00553 (6/6) Cellulose binding domain
PF00126 (6/6) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_31027 305.00 +- 215.00 2 0 0 0 0.02 +- 0.01 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00171 (2/2) Aldehyde dehydrogenase family
PF08031 (1/2) Berberine and berberine like
PF01565 (1/2) FAD binding domain
precursor_jaccard_groups_477 91.84 +- 28.24 7 0 0 0 0.12 +- 0.08 7 10

PF13802 (7/7) Galactose mutarotase-like
PF13377 (7/7) Periplasmic binding protein-like domain
PF01055 (7/7) Glycosyl hydrolases family 31
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00356 (7/7) Bacterial regulatory proteins, lacI family
PF14310 (6/7) Fibronectin type III-like domain
PF03422 (6/7) Carbohydrate binding module (family 6)
PF01915 (6/7) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (6/7) Glycosyl hydrolase family 3 N terminal domain
PF13416 (5/7) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_476 83.15 +- 40.49 3 0 3 0 0.19 +- 0.26 3 13

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13459 (3/3) 4Fe-4S single cluster domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
TIGR01188 (2/3) daunorubicin resistance ABC transporter, ATP-binding protein
PF01061 (2/3) ABC-2 type transporter
PF00501 (2/3) AMP-binding enzyme
PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_22966 24.55 +- 3.14 3 0 0 0 0.17 +- 0.15 3 8

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF17801 (3/3) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (3/3) Alpha galactosidase A
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF07944 (3/3) Beta-L-arabinofuranosidase, GH127
PF05270 (3/3) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03664 (3/3) Glycosyl hydrolase family 62
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_37668 328.15 +- 104.38 2 0 2 0 0.07 +- 0.16 2 15

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
precursor_jaccard_groups_5844 196.47 +- 18.53 2 0 0 0 0.02 +- 0.03 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF15605 (2/2) Bacterial toxin 28
PF07179 (2/2) SseB protein N-terminal domain
PF05593 (2/2) RHS Repeat
PF04149 (2/2) Domain of unknown function (DUF397)
PF15594 (1/2) Immunity protein 50
precursor_jaccard_groups_5843 60.23 +- 18.22 4 0 0 0 0.04 +- 0.02 4 3

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (4/4) MDMPI C-terminal domain
precursor_jaccard_groups_19767 818.85 +- 360.44 3 0 3 0 0.03 +- 0.07 3 14

TIGR00229 (3/3) PAS domain S-box protein
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12832 (3/3) MFS_1 like family
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF01590 (3/3) GAF domain
PF01212 (3/3) Beta-eliminating lyase
PF00989 (3/3) PAS fold
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00156 (3/3) Phosphoribosyl transferase domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_614 82.08 +- 28.09 41 0 0 0 0.17 +- 0.22 41 19

PF13377 (41/41) Periplasmic binding protein-like domain
PF10022 (41/41) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (41/41) DeoR-like helix-turn-helix domain
PF02826 (41/41) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (41/41) Bacterial extracellular solute-binding protein
PF00528 (41/41) Binding-protein-dependent transport system inner membrane component
PF06628 (40/41) Catalase-related immune-responsive
PF06386 (40/41) Gas vesicle synthesis protein GvpL/GvpF
PF05121 (40/41) Gas vesicle protein K
PF05120 (40/41) Gas vesicle protein G
PF03364 (40/41) Polyketide cyclase / dehydrase and lipid transport
PF00741 (40/41) Gas vesicle protein
PF00199 (40/41) Catalase
PF18011 (39/41) C-terminal domain found in long catalases
PF05800 (39/41) Gas vesicle synthesis protein GvpO
PF13649 (31/41) Methyltransferase domain
PF00106 (29/41) short chain dehydrogenase
PF16859 (27/41) Tetracyclin repressor-like, C-terminal domain
PF00440 (27/41) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_21031 254.25 +- 284.68 3 0 3 0 0.09 +- 0.24 3 9

TIGR04462 (3/3) enduracididine biosynthesis enzyme MppP
TIGR04460 (3/3) enduracididine biosynthesis enzyme MppR
PF12697 (3/3) Alpha/beta hydrolase family
PF06314 (3/3) Acetoacetate decarboxylase (ADC)
PF03621 (3/3) MbtH-like protein
PF03301 (3/3) Tryptophan 2,3-dioxygenase
PF00891 (3/3) O-methyltransferase domain
PF00535 (3/3) Glycosyl transferase family 2
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_21032 1326.22 +- 281.32 2 0 0 0 0.01 +- 0.01 2 15

TIGR02960 (2/2) RNA polymerase sigma-70 factor, TIGR02960 family
PF14330 (2/2) Domain of unknown function (DUF4387)
PF08281 (2/2) Sigma-70, region 4
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF07287 (2/2) Acyclic terpene utilisation family protein AtuA
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01872 (2/2) RibD C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_42786 85.66 +- 58.78 2 0 0 0 0.07 +- 0.17 2 6

PF13545 (2/2) Crp-like helix-turn-helix domain
PF11575 (2/2) FhuF 2Fe-2S C-terminal domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_21036 339.61 +- 180.52 3 0 0 0 0.07 +- 0.11 3 7

TIGR03296 (3/3) M6 family metalloprotease domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_40726 102.27 +- 3.04 2 0 2 0 0.08 +- 0.03 2 14

PF16901 (2/2) C-terminal domain of alpha-glycerophosphate oxidase
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF04978 (2/2) Protein of unknown function (DUF664)
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_40092 13.01 +- 2.18 2 0 0 0 0.19 +- 0.06 2 3

PF00704 (2/2) Glycosyl hydrolases family 18
PF00082 (2/2) Subtilase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_16751 1905.20 +- 308.06 3 0 3 3 0.02 +- 0.02 3 11

PF16864 (3/3) Dimerisation domain
PF13471 (3/3) Transglutaminase-like superfamily
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01494 (3/3) FAD binding domain
PF00891 (3/3) O-methyltransferase domain
PF00733 (3/3) Asparagine synthase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17905 30.60 +- 5.27 3 0 0 0 0.11 +- 0.14 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12806 (3/3) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (3/3) Acyl-CoA dehydrogenase N terminal
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00664 (3/3) ABC transporter transmembrane region
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_20036 22.31 +- 1.63 2 0 0 0 0.09 +- 0.13 2 4

PF18564 (2/2) Glycoside hydrolase family 5 C-terminal domain
PF14016 (2/2) Protein of unknown function (DUF4232)
PF01425 (2/2) Amidase
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_17456 187.64 +- 18.76 2 0 0 0 0.05 +- 0.04 2 8

PF14016 (2/2) Protein of unknown function (DUF4232)
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (2/2) Alpha mannosidase middle domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_25273 60.92 +- 3.58 2 0 2 0 0.03 +- 0.02 2 3

PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_45110 80.93 +- 54.86 2 0 2 0 0.09 +- 0.07 2 9

TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01546 (2/2) Peptidase family M20/M25/M40
PF01522 (2/2) Polysaccharide deacetylase
precursor_jaccard_groups_45113 208.79 +- 51.21 2 0 2 0 0.05 +- 0.09 2 9

PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07920 (2/2) Protein of unknown function (DUF1684)
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02655 (2/2) ATP-grasp domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28445 994.22 +- 94.22 2 0 0 0 0.02 +- 0.02 2 14

TIGR04416 (2/2) group II intron reverse transcriptase/maturase
PF14759 (2/2) Reductase C-terminal
PF08388 (2/2) Group II intron, maturase-specific domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04213 (2/2) Htaa
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00665 (2/2) Integrase core domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00248 (2/2) Aldo/keto reductase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_45118 16.92 +- 1.44 2 0 0 0 0.18 +- 0.30 2 3

PF13649 (2/2) Methyltransferase domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_28993 84.78 +- 0.00 2 0 2 0 0.06 +- 0.08 2 6

PF14759 (2/2) Reductase C-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09335 (2/2) SNARE associated Golgi protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_3472 635.55 +- 515.64 10 0 10 10 0.04 +- 0.18 10 7

TIGR03891 (10/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (10/10) Lantibiotic biosynthesis dehydratase C-term
PF05147 (10/10) Lanthionine synthetase C-like protein
PF04738 (10/10) Lantibiotic dehydratase, N terminus
PF00664 (8/10) ABC transporter transmembrane region
PF00005 (8/10) ABC transporter
PF13302 (7/10) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_28287 1971.40 +- 122.51 2 0 2 2 0.03 +- 0.07 2 20

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF13520 (2/2) Amino acid permease
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07978 (2/2) NIPSNAP
PF07691 (2/2) PA14 domain
PF05977 (2/2) Transmembrane secretion effector
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00975 (2/2) Thioesterase domain
PF00733 (2/2) Asparagine synthase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_44422 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_jaccard_groups_28283 131.16 +- 62.34 2 0 0 0 0.03 +- 0.03 2 4

PF18370 (2/2) Rhamnogalacturonan I lyases beta-sheet domain
PF10503 (2/2) Esterase PHB depolymerase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_26840 929.22 +- 318.78 2 0 0 0 0.01 +- 0.03 2 10

PF14307 (2/2) Glycosyltransferase WbsX
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01061 (2/2) ABC-2 type transporter
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4319 115.85 +- 65.26 7 0 3 0 0.06 +- 0.08 7 2

PF07702 (7/7) UTRA domain
PF00392 (7/7) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_41082 106.52 +- 6.52 2 0 0 0 0.04 +- 0.01 2 4

TIGR01733 (2/2) amino acid adenylation domain
PF07859 (2/2) alpha/beta hydrolase fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_44428 166.53 +- 14.34 2 0 2 0 0.07 +- 0.15 2 10

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF03861 (2/2) ANTAR domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00571 (2/2) CBS domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_4031 25.16 +- 8.72 3 0 0 0 0.14 +- 0.19 3 3

PF13649 (3/3) Methyltransferase domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (3/3) Major Facilitator Superfamily
precursor_jaccard_groups_2655 89.17 +- 44.69 10 0 0 0 0.15 +- 0.09 10 4

PF13400 (10/10) Putative Flp pilus-assembly TadE/G-like
PF07811 (10/10) TadE-like protein
PF00482 (10/10) Type II secretion system (T2SS), protein F
PF00437 (10/10) Type II/IV secretion system protein
precursor_jaccard_groups_34572 42.17 +- 14.56 2 0 2 0 0.11 +- 0.20 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF05834 (2/2) Lycopene cyclase protein
PF02082 (2/2) Transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
precursor_jaccard_groups_36650 496.76 +- 283.24 2 0 2 0 0.02 +- 0.01 2 15

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_jaccard_groups_2659 11.42 +- 2.72 4 0 3 0 0.19 +- 0.21 4 5

PF01061 (4/4) ABC-2 type transporter
PF00498 (4/4) FHA domain
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF16697 (2/4) Inner membrane component of T3SS, cytoplasmic domain
precursor_jaccard_groups_37936 238.97 +- 31.03 2 0 2 0 0.04 +- 0.05 2 14

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF12680 (2/2) SnoaL-like domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03704 (2/2) Bacterial transcriptional activator domain
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_102 386.93 +- 278.10 7 0 7 7 0.05 +- 0.13 7 11

TIGR03897 (7/7) type 2 lantibiotic biosynthesis protein LanM
PF13575 (7/7) Domain of unknown function (DUF4135)
PF13191 (7/7) AAA ATPase domain
PF05147 (7/7) Lanthionine synthetase C-like protein
PF03704 (7/7) Bacterial transcriptional activator domain
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00196 (7/7) Bacterial regulatory proteins, luxR family
PF00931 (6/7) NB-ARC domain
PF13185 (4/7) GAF domain
PF08448 (4/7) PAS fold
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_43166 276.53 +- 70.13 2 0 0 0 0.03 +- 0.04 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_34760 1424.50 +- 5.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR02946 (2/2) acyltransferase, WS/DGAT/MGAT
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06974 (2/2) Protein of unknown function (DUF1298)
PF03007 (2/2) Wax ester synthase-like Acyl-CoA acyltransferase domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11840 528.78 +- 87.12 4 0 4 0 0.02 +- 0.03 4 6

PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_11846 191.07 +- 76.21 4 0 0 0 0.01 +- 0.01 4 2

PF13602 (4/4) Zinc-binding dehydrogenase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_43169 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_28193 1956.02 +- 301.48 2 0 0 0 0.01 +- 0.00 2 6

PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02449 (2/2) Beta-galactosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_45600 57.21 +- 7.97 2 0 0 0 0.10 +- 0.10 2 12

TIGR03217 (2/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/2) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (2/2) DmpG-like communication domain
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00296 (2/2) Luciferase-like monooxygenase
PF07690 (1/2) Major Facilitator Superfamily
PF00083 (1/2) Sugar (and other) transporter
precursor_jaccard_groups_45603 148.29 +- 74.57 2 0 0 0 0.03 +- 0.02 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_38106 148.71 +- 51.96 2 0 0 0 0.05 +- 0.05 2 6

PF14279 (2/2) HNH endonuclease
PF13560 (2/2) Helix-turn-helix domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF07508 (2/2) Recombinase
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF00239 (2/2) Resolvase, N terminal domain
precursor_jaccard_groups_31943 262.23 +- 11.40 2 0 0 0 0.04 +- 0.03 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02467 (2/2) Transcription factor WhiB
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_17051 46.93 +- 15.30 3 0 0 0 0.23 +- 0.20 3 9

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_7208 35.11 +- 9.73 6 0 0 0 0.12 +- 0.16 6 4

PF07690 (6/6) Major Facilitator Superfamily
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (6/6) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (6/6) Acetyltransferase (GNAT) family
precursor_jaccard_groups_34363 518.00 +- 2.00 2 0 0 2 0.01 +- 0.00 2 5

TIGR03930 (2/2) WXG100 family type VII secretion target
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_4953 12.41 +- 4.04 4 0 0 0 0.20 +- 0.20 4 6

PF10282 (4/4) Lactonase, 7-bladed beta-propeller
PF07702 (4/4) UTRA domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
TIGR03173 (2/4) xanthine permease
PF00860 (2/4) Permease family
PF00561 (2/4) alpha/beta hydrolase fold
precursor_jaccard_groups_25486 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_43566 74.02 +- 1.46 2 0 1 0 0.04 +- 0.04 2 5

TIGR04538 (2/2) cytochrome P450, cyclodipeptide synthase-associated
PF13191 (2/2) AAA ATPase domain
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_25480 334.54 +- 310.46 2 0 0 0 0.11 +- 0.22 2 8

PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_34365 55.98 +- 0.00 2 0 0 0 0.20 +- 0.37 2 13

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
TIGR00544 (2/2) prolipoprotein diacylglyceryl transferase
PF13462 (2/2) Thioredoxin
PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01988 (2/2) VIT family
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF01790 (2/2) Prolipoprotein diacylglyceryl transferase
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_23884 171.39 +- 0.64 2 0 2 0 0.09 +- 0.25 2 21

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF08659 (2/2) KR domain
PF05199 (2/2) GMC oxidoreductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00732 (2/2) GMC oxidoreductase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_24605 32.16 +- 19.16 2 0 0 0 0.14 +- 0.29 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_jaccard_groups_24353 1361.71 +- 233.20 2 0 0 0 0.02 +- 0.00 2 17

TIGR02118 (2/2) conserved hypothetical protein
TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07110 (2/2) EthD domain
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF01636 (2/2) Phosphotransferase enzyme family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00108 (2/2) Thiolase, N-terminal domain
precursor_jaccard_groups_23802 14.59 +- 2.01 2 0 0 0 0.14 +- 0.07 2 5

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF14378 (1/2) PAP2 superfamily
precursor_jaccard_groups_37401 39.49 +- 10.60 2 0 2 0 0.13 +- 0.10 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF07045 (2/2) Domain of unknown function (DUF1330)
PF03403 (2/2) Platelet-activating factor acetylhydrolase, isoform II
PF01047 (2/2) MarR family
PF01148 (1/2) Cytidylyltransferase family
PF00155 (1/2) Aminotransferase class I and II
precursor_jaccard_groups_5444 698.38 +- 267.94 8 0 0 8 0.01 +- 0.00 8 4

PF07690 (8/8) Major Facilitator Superfamily
PF04055 (8/8) Radical SAM superfamily
PF02441 (8/8) Flavoprotein
PF02310 (4/8) B12 binding domain
precursor_jaccard_groups_1860 451.91 +- 137.60 5 0 5 5 0.01 +- 0.01 5 6

TIGR04364 (5/5) methyltransferase, FxLD system
TIGR03891 (5/5) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF05147 (5/5) Lanthionine synthetase C-like protein
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF01135 (5/5) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_jaccard_groups_28074 55.71 +- 30.95 2 0 0 0 0.05 +- 0.09 2 2

PF07876 (2/2) Stress responsive A/B Barrel Domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
precursor_jaccard_groups_11987 268.55 +- 266.44 3 0 0 0 0.06 +- 0.12 3 5

TIGR03620 (3/3) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF12802 (3/3) MarR family
PF07859 (3/3) alpha/beta hydrolase fold
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_43366 47.14 +- 1.61 2 0 0 0 0.04 +- 0.04 2 10

TIGR03351 (2/2) phosphonatase-like hydrolase
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF07702 (2/2) UTRA domain
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_43367 36.62 +- 5.24 2 0 0 0 0.20 +- 0.18 2 12

TIGR01234 (2/2) ribulokinase
PF13377 (2/2) Periplasmic binding protein-like domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF03473 (2/2) MOSC domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_2784 58.11 +- 27.96 2 0 2 2 0.17 +- 0.33 2 10

PF07730 (2/2) Histidine kinase
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03793 (2/2) PASTA domain
PF00664 (2/2) ABC transporter transmembrane region
PF00326 (2/2) Prolyl oligopeptidase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3302 1451.44 +- 885.96 11 0 11 0 0.01 +- 0.01 11 11

PF16197 (11/11) Ketoacyl-synthetase C-terminal extension
PF13535 (11/11) ATP-grasp domain
PF07690 (11/11) Major Facilitator Superfamily
PF02801 (11/11) Beta-ketoacyl synthase, C-terminal domain
PF00975 (11/11) Thioesterase domain
PF00698 (11/11) Acyl transferase domain
PF00550 (11/11) Phosphopantetheine attachment site
PF00109 (11/11) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (10/11) amino acid adenylation domain
PF13193 (10/11) AMP-binding enzyme C-terminal domain
PF00501 (10/11) AMP-binding enzyme
precursor_jaccard_groups_3653 99.38 +- 16.84 2 0 0 0 0.10 +- 0.24 2 24

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR02009 (2/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (2/2) Glyoxalase-like domain
PF17866 (2/2) AAA lid domain
PF14436 (2/2) Bacterial EndoU nuclease
PF13560 (2/2) Helix-turn-helix domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF13229 (2/2) Right handed beta helix region
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (2/2) Cupin domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03636 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_3309 324.83 +- 216.12 10 0 3 0 0.11 +- 0.21 10 14

TIGR00928 (10/10) adenylosuccinate lyase
TIGR00711 (10/10) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (10/10) Acetyltransferase (GNAT) domain
PF07690 (10/10) Major Facilitator Superfamily
PF01814 (10/10) Hemerythrin HHE cation binding domain
PF01425 (10/10) Amidase
PF00486 (10/10) Transcriptional regulatory protein, C terminal
PF00206 (10/10) Lyase
PF00120 (10/10) Glutamine synthetase, catalytic domain
PF00072 (10/10) Response regulator receiver domain
PF12800 (9/10) 4Fe-4S binding domain
PF13460 (6/10) NAD(P)H-binding
PF01494 (6/10) FAD binding domain
PF00561 (6/10) alpha/beta hydrolase fold
precursor_jaccard_groups_43369 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_11998 662.17 +- 72.93 4 0 4 0 0.01 +- 0.00 4 17

TIGR01679 (4/4) FAD-linked oxidoreductase
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01122 (4/4) branched-chain amino acid aminotransferase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08666 (4/4) SAF domain
PF04321 (4/4) RmlD substrate binding domain
PF04030 (4/4) D-arabinono-1,4-lactone oxidase
PF03737 (4/4) Aldolase/RraA
PF03102 (4/4) NeuB family
PF02780 (4/4) Transketolase, C-terminal domain
PF02779 (4/4) Transketolase, pyrimidine binding domain
PF01565 (4/4) FAD binding domain
PF01063 (4/4) Amino-transferase class IV
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
TIGR00473 (3/4) CDP-diacylglycerol-serine O-phosphatidyltransferase
PF01066 (3/4) CDP-alcohol phosphatidyltransferase
precursor_jaccard_groups_33812 55.60 +- 12.20 2 0 2 0 0.17 +- 0.17 2 10

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11992 39.12 +- 8.89 4 0 0 0 0.09 +- 0.08 4 7

PF18050 (4/4) Cyclophilin-like family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00107 (4/4) Zinc-binding dehydrogenase
PF00106 (4/4) short chain dehydrogenase
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF02065 (2/4) Melibiase
precursor_jaccard_groups_11996 136.23 +- 2.56 2 0 1 0 0.12 +- 0.19 2 15

PF14592 (2/2) Chondroitinase B
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13378 (2/2) Enolase C-terminal domain-like
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07729 (2/2) FCD domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01120 (2/2) Alpha-L-fucosidase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_1 163.00 +- 102.82 7 0 0 1 0.06 +- 0.16 7 2

PF04149 (7/7) Domain of unknown function (DUF397)
PF13560 (6/7) Helix-turn-helix domain
precursor_jaccard_groups_2 62.32 +- 74.74 22 0 2 0 0.11 +- 0.22 22 2

PF04149 (22/22) Domain of unknown function (DUF397)
PF13560 (20/22) Helix-turn-helix domain
precursor_jaccard_groups_4 66.88 +- 66.48 4 0 0 0 0.12 +- 0.23 4 7

PF04149 (4/4) Domain of unknown function (DUF397)
PF13560 (2/4) Helix-turn-helix domain
PF03992 (2/4) Antibiotic biosynthesis monooxygenase
PF03752 (2/4) Short repeats of unknown function
PF01381 (2/4) Helix-turn-helix
PF00857 (2/4) Isochorismatase family
PF00583 (2/4) Acetyltransferase (GNAT) family
precursor_jaccard_groups_5 77.90 +- 96.46 8 0 0 1 0.10 +- 0.21 8 4

PF13560 (8/8) Helix-turn-helix domain
PF04149 (8/8) Domain of unknown function (DUF397)
PF13302 (5/8) Acetyltransferase (GNAT) domain
PF00069 (5/8) Protein kinase domain
precursor_jaccard_groups_9 113.22 +- 141.39 13 0 4 0 0.07 +- 0.12 13 4

PF13560 (13/13) Helix-turn-helix domain
PF04149 (13/13) Domain of unknown function (DUF397)
PF05899 (7/13) Protein of unknown function (DUF861)
PF05685 (7/13) Putative restriction endonuclease
precursor_jaccard_groups_34583 181.70 +- 78.30 2 0 0 0 0.04 +- 0.05 2 9

PF14552 (2/2) Tautomerase enzyme
PF13546 (2/2) DDE superfamily endonuclease
PF12706 (2/2) Beta-lactamase superfamily domain
PF07859 (2/2) alpha/beta hydrolase fold
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01361 (2/2) Tautomerase enzyme
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_18480 52.15 +- 4.37 2 0 0 0 0.08 +- 0.06 2 6

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_35216 110.30 +- 63.03 2 0 0 0 0.03 +- 0.02 2 5

PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
precursor_jaccard_groups_7551 332.28 +- 117.15 5 0 0 5 0.01 +- 0.01 5 5

TIGR04267 (5/5) HEXXH motif domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF04055 (5/5) Radical SAM superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_18487 358.75 +- 32.16 2 0 0 0 0.01 +- 0.01 2 18

TIGR01558 (2/2) putative phage terminase, small subunit, P27 family
TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/2) Phage-related minor tail protein
PF05119 (2/2) Phage terminase, small subunit
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04586 (2/2) Caudovirus prohead serine protease
PF04542 (2/2) Sigma-70 region 2
PF03354 (2/2) Phage Terminase
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (2/2) Collagen triple helix repeat (20 copies)
PF01381 (2/2) Helix-turn-helix
PF00271 (2/2) Helicase conserved C-terminal domain
precursor_jaccard_groups_32244 488.91 +- 421.09 2 0 0 0 0.06 +- 0.23 2 12

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11136 (2/2) Protein of unknown function (DUF2889)
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00384 (2/2) Molybdopterin oxidoreductase
PF00106 (2/2) short chain dehydrogenase
TIGR01915 (1/2) NADPH-dependent F420 reductase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
precursor_jaccard_groups_43014 1363.59 +- 571.41 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_5206 43.66 +- 3.32 5 0 0 0 0.23 +- 0.32 5 12

TIGR03177 (5/5) Flp pilus assembly protein CpaB
PF16976 (5/5) Flp pilus assembly protein RcpC/CpaB
PF13614 (5/5) AAA domain
PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF07730 (5/5) Histidine kinase
PF04964 (5/5) Flp/Fap pilin component
PF00691 (5/5) OmpA family
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
precursor_jaccard_groups_7559 204.09 +- 95.16 6 0 2 0 0.06 +- 0.02 6 10

PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00378 (6/6) Enoyl-CoA hydratase/isomerase
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00005 (6/6) ABC transporter
PF13561 (5/6) Enoyl-(Acyl carrier protein) reductase
PF08545 (5/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01144 (5/6) Coenzyme A transferase
PF00106 (5/6) short chain dehydrogenase
precursor_jaccard_groups_82 75.20 +- 73.79 11 0 11 0 0.13 +- 0.27 11 3

PF06236 (11/11) Tyrosinase co-factor MelC1
PF03777 (11/11) ChpA-C
PF00264 (11/11) Common central domain of tyrosinase
precursor_jaccard_groups_32408 68.31 +- 1.00 2 0 0 0 0.09 +- 0.20 2 13

TIGR03885 (2/2) probable non-F420 flavinoid oxidoreductase
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16657 (2/2) Maltogenic Amylase, C-terminal domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF13384 (2/2) Homeodomain-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF05231 (2/2) MASE1
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF00296 (2/2) Luciferase-like monooxygenase
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_13295 121.56 +- 12.45 4 0 4 0 0.12 +- 0.17 4 9

TIGR01187 (4/4) polyamine ABC transporter, ATP-binding protein
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08402 (4/4) TOBE domain
PF01593 (4/4) Flavin containing amine oxidoreductase
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00171 (4/4) Aldehyde dehydrogenase family
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_8093 96.44 +- 32.56 2 0 2 0 0.23 +- 0.33 2 20

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF13822 (1/2) Acyl-CoA carboxylase epsilon subunit
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12697 (1/2) Alpha/beta hydrolase family
PF05977 (1/2) Transmembrane secretion effector
PF03358 (1/2) NADPH-dependent FMN reductase
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_25621 88.43 +- 21.02 2 0 0 0 0.03 +- 0.04 2 9

TIGR01840 (2/2) esterase, PHB depolymerase family
PF18143 (2/2) HAD domain in Swiss Army Knife RNA repair proteins
PF13279 (2/2) Thioesterase-like superfamily
PF12972 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
PF12971 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF09362 (2/2) Domain of unknown function (DUF1996)
PF05089 (2/2) Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
PF03713 (2/2) Domain of unknown function (DUF305)
precursor_jaccard_groups_14010 31.71 +- 1.94 2 0 0 0 0.09 +- 0.09 2 4

PF09992 (2/2) Phosphodiester glycosidase
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF05036 (2/2) Sporulation related domain
PF00756 (2/2) Putative esterase
precursor_jaccard_groups_42717 272.88 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR00212 (2/2) hydroxymethylbilane synthase
PF05977 (2/2) Transmembrane secretion effector
PF01379 (2/2) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF03900 (1/2) Porphobilinogen deaminase, C-terminal domain
precursor_jaccard_groups_2438 58.80 +- 18.26 7 0 0 0 0.21 +- 0.17 7 7

TIGR03860 (7/7) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (7/7) NMT1/THI5 like
PF02668 (7/7) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00480 (7/7) ROK family
PF00296 (7/7) Luciferase-like monooxygenase
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_9482 26.76 +- 10.80 5 0 5 0 0.18 +- 0.37 5 6

TIGR01751 (5/5) crotonyl-CoA carboxylase/reductase
PF11236 (5/5) Protein of unknown function (DUF3037)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF00107 (5/5) Zinc-binding dehydrogenase
PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_12985 26.91 +- 4.49 2 0 0 0 0.20 +- 0.30 2 25

TIGR02378 (2/2) nitrite reductase [NAD(P)H], small subunit
TIGR02374 (2/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (2/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (2/2) Rieske-like [2Fe-2S] domain
PF13560 (2/2) Helix-turn-helix domain
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF03460 (2/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (2/2) Nitrite and sulphite reductase 4Fe-4S domain
PF00106 (2/2) short chain dehydrogenase
TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
TIGR01891 (1/2) amidohydrolase
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF14440 (1/2) Xanthomonas XOO_2897-like deaminase
PF14435 (1/2) SUKH-4 immunity protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13520 (1/2) Amino acid permease
PF12840 (1/2) Helix-turn-helix domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08327 (1/2) Activator of Hsp90 ATPase homolog 1-like protein
PF07398 (1/2) MDMPI C-terminal domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF01546 (1/2) Peptidase family M20/M25/M40
precursor_jaccard_groups_42495 54.58 +- 0.35 2 0 0 0 0.20 +- 0.34 2 13

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13578 (2/2) Methyltransferase domain
PF13185 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05199 (2/2) GMC oxidoreductase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7156 158.14 +- 170.69 6 0 6 0 0.11 +- 0.20 6 6

PF08484 (6/6) C-methyltransferase C-terminal domain
PF08421 (6/6) Putative zinc binding domain
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF01061 (6/6) ABC-2 type transporter
PF00908 (6/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_24517 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region
precursor_jaccard_groups_14232 224.27 +- 49.13 3 0 3 0 0.01 +- 0.00 3 4

TIGR01490 (3/3) HAD hydrolase, family IB
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF03756 (3/3) A-factor biosynthesis hotdog domain
precursor_jaccard_groups_5337 207.27 +- 160.94 7 0 7 0 0.13 +- 0.25 7 19

TIGR02980 (7/7) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
TIGR01733 (7/7) amino acid adenylation domain
TIGR01720 (7/7) non-ribosomal peptide synthase domain TIGR01720
PF17196 (7/7) Protein of unknown function (DUF5133)
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12401 (7/7) Protein of unknown function (DUF2662)
PF04545 (7/7) Sigma-70, region 4
PF04542 (7/7) Sigma-70 region 2
PF04539 (7/7) Sigma-70 region 3
PF02518 (7/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01061 (7/7) ABC-2 type transporter
PF00672 (7/7) HAMP domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00512 (7/7) His Kinase A (phospho-acceptor) domain
PF00501 (7/7) AMP-binding enzyme
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00072 (7/7) Response regulator receiver domain
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_464 889.65 +- 952.51 59 5 54 58 0.05 +- 0.15 54 7

TIGR03897 (58/59) type 2 lantibiotic biosynthesis protein LanM
PF13575 (58/59) Domain of unknown function (DUF4135)
PF05147 (58/59) Lanthionine synthetase C-like protein
PF03412 (58/59) Peptidase C39 family
PF00664 (58/59) ABC transporter transmembrane region
PF00005 (58/59) ABC transporter
PF14867 (53/59) Lantibiotic alpha
precursor_jaccard_groups_14239 75.06 +- 30.73 3 0 3 0 0.14 +- 0.19 3 8

PF12833 (3/3) Helix-turn-helix domain
PF03259 (3/3) Roadblock/LC7 domain
PF01965 (3/3) DJ-1/PfpI family
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (3/3) Aldehyde dehydrogenase family
PF04237 (2/3) YjbR
precursor_jaccard_groups_31534 17.64 +- 0.00 2 0 0 0 0.23 +- 0.37 2 5

PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF03745 (2/2) Domain of unknown function (DUF309)
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_15638 350.57 +- 233.96 3 0 3 0 0.07 +- 0.24 3 8

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03621 (3/3) MbtH-like protein
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_8992 672.14 +- 574.84 5 0 0 0 0.03 +- 0.02 5 5

PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
precursor_jaccard_groups_8998 234.03 +- 30.26 5 0 5 5 0.01 +- 0.00 5 7

TIGR03975 (5/5) ribosomal peptide maturation radical SAM protein 1
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF08241 (4/5) Methyltransferase domain
PF13424 (3/5) Tetratricopeptide repeat
PF03704 (3/5) Bacterial transcriptional activator domain
PF00931 (3/5) NB-ARC domain
precursor_jaccard_groups_15632 55.61 +- 3.48 2 0 2 0 0.22 +- 0.39 2 10

PF13407 (2/2) Periplasmic binding protein domain
PF12802 (2/2) MarR family
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00550 (2/2) Phosphopantetheine attachment site
PF00480 (2/2) ROK family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32332 36.01 +- 8.86 2 0 2 0 0.06 +- 0.08 2 3

PF14019 (2/2) Protein of unknown function (DUF4235)
PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_jaccard_groups_39723 1346.54 +- 1013.21 2 0 0 0 0.02 +- 0.02 2 14

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/2) AAA-like domain
PF12642 (2/2) Conjugative transposon protein TcpC
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00877 (2/2) NlpC/P60 family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF13406 (1/2) Transglycosylase SLT domain
PF01478 (1/2) Type IV leader peptidase family
PF00691 (1/2) OmpA family
PF00293 (1/2) NUDIX domain
precursor_jaccard_groups_9461 66.14 +- 7.57 2 0 2 0 0.18 +- 0.26 2 10

PF13560 (2/2) Helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07883 (2/2) Cupin domain
PF03466 (2/2) LysR substrate binding domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_2324 130.09 +- 105.34 3 0 0 3 0.09 +- 0.25 3 18

TIGR04504 (3/3) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (3/3) mycofactocin precursor
TIGR03967 (3/3) putative mycofactocin binding protein MftB
TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (3/3) mycofactocin system glycosyltransferase
TIGR03964 (3/3) mycofactocin system creatininase family protein
TIGR03962 (3/3) mycofactocin radical SAM maturase
TIGR02188 (3/3) acetate--CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF04055 (3/3) Radical SAM superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
PF00501 (3/3) AMP-binding enzyme
PF00406 (3/3) Adenylate kinase
PF13186 (2/3) Iron-sulfur cluster-binding domain
precursor_jaccard_groups_35187 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR02418 (2/2) acetolactate synthase, catabolic
TIGR01252 (2/2) alpha-acetolactate decarboxylase
PF03306 (2/2) Alpha-acetolactate decarboxylase
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_7792 41.87 +- 25.41 4 0 0 0 0.07 +- 0.03 4 2

PF06751 (4/4) Ethanolamine ammonia lyase large subunit (EutB)
PF05985 (4/4) Ethanolamine ammonia-lyase light chain (EutC)
precursor_jaccard_groups_13585 375.66 +- 254.28 4 0 0 0 0.04 +- 0.16 4 4

PF17914 (4/4) HopA1 effector protein family
PF13649 (4/4) Methyltransferase domain
PF02441 (4/4) Flavoprotein
PF01636 (2/4) Phosphotransferase enzyme family
precursor_jaccard_groups_7806 59.96 +- 20.77 5 0 3 0 0.10 +- 0.13 5 6

PF13653 (5/5) Glycerophosphoryl diester phosphodiesterase family
PF07690 (5/5) Major Facilitator Superfamily
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (5/5) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (5/5) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (5/5) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_3926 128.39 +- 49.44 10 0 5 0 0.14 +- 0.14 10 16

PF13407 (10/10) Periplasmic binding protein domain
PF13378 (10/10) Enolase C-terminal domain-like
PF07729 (10/10) FCD domain
PF05025 (10/10) RbsD / FucU transport protein family
PF02746 (10/10) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (10/10) Branched-chain amino acid transport system / permease component
PF00392 (10/10) Bacterial regulatory proteins, gntR family
PF00005 (10/10) ABC transporter
PF13561 (9/10) Enoyl-(Acyl carrier protein) reductase
PF08240 (9/10) Alcohol dehydrogenase GroES-like domain
PF01081 (9/10) KDPG and KHG aldolase
PF00294 (9/10) pfkB family carbohydrate kinase
PF00248 (9/10) Aldo/keto reductase family
PF00107 (9/10) Zinc-binding dehydrogenase
TIGR01182 (8/10) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF04909 (8/10) Amidohydrolase
precursor_jaccard_groups_1533 442.88 +- 425.57 13 0 13 0 0.08 +- 0.23 13 14

TIGR01733 (13/13) amino acid adenylation domain
PF13193 (13/13) AMP-binding enzyme C-terminal domain
PF03621 (13/13) MbtH-like protein
PF00668 (13/13) Condensation domain
PF00550 (13/13) Phosphopantetheine attachment site
PF00501 (13/13) AMP-binding enzyme
PF00975 (12/13) Thioesterase domain
TIGR04020 (11/13) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01720 (11/13) non-ribosomal peptide synthase domain TIGR01720
PF16197 (11/13) Ketoacyl-synthetase C-terminal extension
PF02801 (11/13) Beta-ketoacyl synthase, C-terminal domain
PF00296 (11/13) Luciferase-like monooxygenase
PF00109 (11/13) Beta-ketoacyl synthase, N-terminal domain
PF07690 (10/13) Major Facilitator Superfamily
precursor_jaccard_groups_10034 9.00 +- 0.00 2 0 0 0 0.22 +- 0.13 2 4

PF03471 (2/2) Transporter associated domain
PF01595 (2/2) Cyclin M transmembrane N-terminal domain
PF00582 (2/2) Universal stress protein family
PF00571 (2/2) CBS domain
precursor_jaccard_groups_1823 820.78 +- 765.26 16 0 16 1 0.03 +- 0.10 16 14

TIGR01850 (16/16) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (16/16) alpha-L-glutamate ligase, RimK family
PF08443 (16/16) RimK-like ATP-grasp domain
PF02780 (16/16) Transketolase, C-terminal domain
PF02779 (16/16) Transketolase, pyrimidine binding domain
PF01118 (16/16) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (16/16) Transketolase, thiamine diphosphate binding domain
PF13193 (15/16) AMP-binding enzyme C-terminal domain
PF02771 (15/16) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (15/16) Acyl-CoA dehydrogenase, middle domain
PF00501 (15/16) AMP-binding enzyme
PF00441 (15/16) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (10/16) LysR substrate binding domain
PF00126 (10/16) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_8841 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_6335 140.33 +- 50.33 2 0 2 0 0.07 +- 0.18 2 16

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF16864 (1/2) Dimerisation domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF03621 (1/2) MbtH-like protein
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01937 (1/2) Protein of unknown function DUF89
PF00975 (1/2) Thioesterase domain
PF00891 (1/2) O-methyltransferase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_43944 69.46 +- 4.96 2 0 0 0 0.04 +- 0.04 2 8

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12802 (1/2) MarR family
precursor_jaccard_groups_4555 58.51 +- 2.56 2 0 0 0 0.19 +- 0.18 2 10

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13671 (1/2) AAA domain
PF03404 (1/2) Mo-co oxidoreductase dimerisation domain
PF00174 (1/2) Oxidoreductase molybdopterin binding domain
precursor_jaccard_groups_36431 812.16 +- 80.91 2 0 2 0 0.02 +- 0.04 2 10

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03412 (2/2) Peptidase C39 family
PF01636 (2/2) Phosphotransferase enzyme family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_18807 517.33 +- 1.89 3 0 0 0 0.01 +- 0.00 3 7

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF05141 (3/3) Pyoverdine/dityrosine biosynthesis protein
PF04820 (3/3) Tryptophan halogenase
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01565 (3/3) FAD binding domain
precursor_jaccard_groups_41592 142.58 +- 0.76 2 0 2 2 0.01 +- 0.01 2 3

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_2928 244.72 +- 31.94 12 0 0 0 0.01 +- 0.00 12 3

PF13545 (12/12) Crp-like helix-turn-helix domain
PF07228 (12/12) Stage II sporulation protein E (SpoIIE)
PF00027 (12/12) Cyclic nucleotide-binding domain
precursor_jaccard_groups_1794 14.15 +- 3.62 13 0 1 0 0.16 +- 0.12 13 5

PF05331 (13/13) Protein of unknown function (DUF742)
PF03259 (13/13) Roadblock/LC7 domain
PF03029 (13/13) Conserved hypothetical ATP binding protein
PF00672 (13/13) HAMP domain
PF02518 (12/13) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_23655 42.47 +- 9.53 2 0 1 0 0.07 +- 0.05 2 9

TIGR00641 (2/2) methylmalonyl-CoA mutase N-terminal domain
PF14435 (2/2) SUKH-4 immunity protein
PF03308 (2/2) Methylmalonyl Co-A mutase-associated GTPase MeaB
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02310 (2/2) B12 binding domain
PF01642 (2/2) Methylmalonyl-CoA mutase
PF01321 (2/2) Creatinase/Prolidase N-terminal domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00557 (2/2) Metallopeptidase family M24
precursor_jaccard_groups_14342 35.83 +- 7.17 2 0 1 0 0.06 +- 0.02 2 6

PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06439 (2/2) Domain of Unknown Function (DUF1080)
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF00801 (2/2) PKD domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_1792 180.60 +- 77.40 2 0 0 0 0.01 +- 0.01 2 2

PF02547 (2/2) Queuosine biosynthesis protein
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_4797 63.69 +- 4.57 4 0 4 0 0.20 +- 0.32 4 19

PF14027 (4/4) Questin oxidase-like
PF13822 (4/4) Acyl-CoA carboxylase epsilon subunit
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF12697 (4/4) Alpha/beta hydrolase family
PF10604 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF07690 (4/4) Major Facilitator Superfamily
PF04673 (4/4) Polyketide synthesis cyclase
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01494 (4/4) FAD binding domain
PF01039 (4/4) Carboxyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00106 (4/4) short chain dehydrogenase
PF07732 (3/4) Multicopper oxidase
PF07731 (3/4) Multicopper oxidase
PF00394 (3/4) Multicopper oxidase
PF00364 (3/4) Biotin-requiring enzyme
PF02786 (2/4) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (2/4) Biotin carboxylase C-terminal domain
precursor_jaccard_groups_6440 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_27416 27.04 +- 2.28 2 0 0 0 0.15 +- 0.04 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF14667 (1/2) Polysaccharide biosynthesis C-terminal domain
precursor_jaccard_groups_37123 409.91 +- 174.38 2 0 0 0 0.04 +- 0.06 2 11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF12802 (2/2) MarR family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_27704 233.00 +- 25.00 2 0 0 0 0.01 +- 0.00 2 2

PF13460 (2/2) NAD(P)H-binding
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_9269 42.67 +- 9.06 5 0 0 0 0.07 +- 0.05 5 9

PF03450 (5/5) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (5/5) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (5/5) [2Fe-2S] binding domain
PF01315 (5/5) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (5/5) FAD binding domain in molybdopterin dehydrogenase
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF13478 (4/5) XdhC Rossmann domain
PF09339 (4/5) IclR helix-turn-helix domain
PF02625 (4/5) XdhC and CoxI family
precursor_jaccard_groups_826 94.48 +- 21.19 37 0 0 0 0.14 +- 0.25 37 11

PF08795 (37/37) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (37/37) Animal haem peroxidase
PF02585 (37/37) GlcNAc-PI de-N-acetylase
PF01061 (37/37) ABC-2 type transporter
PF00933 (37/37) Glycosyl hydrolase family 3 N terminal domain
PF00582 (37/37) Universal stress protein family
PF00199 (37/37) Catalase
PF00005 (37/37) ABC transporter
TIGR00229 (34/37) PAS domain S-box protein
PF00196 (34/37) Bacterial regulatory proteins, luxR family
PF00989 (31/37) PAS fold
precursor_jaccard_groups_42021 314.08 +- 75.92 2 0 0 0 0.01 +- 0.02 2 7

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF00296 (2/2) Luciferase-like monooxygenase
PF01494 (1/2) FAD binding domain
precursor_jaccard_groups_18732 468.39 +- 129.56 3 0 0 0 0.02 +- 0.01 3 7

TIGR02798 (3/3) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12697 (3/3) Alpha/beta hydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF03737 (3/3) Aldolase/RraA
PF02426 (3/3) Muconolactone delta-isomerase
PF02585 (2/3) GlcNAc-PI de-N-acetylase
precursor_jaccard_groups_9263 625.39 +- 132.43 5 0 0 0 0.01 +- 0.01 5 6

TIGR03930 (5/5) WXG100 family type VII secretion target
TIGR03921 (5/5) type VII secretion-associated serine protease mycosin
TIGR03919 (5/5) type VII secretion protein EccB
PF06013 (5/5) Proteins of 100 residues with WXG
PF05108 (5/5) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/5) Subtilase family
precursor_jaccard_groups_6207 37.97 +- 11.97 2 0 0 0 0.20 +- 0.23 2 13

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13602 (2/2) Zinc-binding dehydrogenase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01546 (2/2) Peptidase family M20/M25/M40
PF00672 (2/2) HAMP domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
TIGR04037 (1/2) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (1/2) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF03358 (1/2) NADPH-dependent FMN reductase
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_31238 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_10108 26.75 +- 3.45 5 0 0 0 0.08 +- 0.14 5 14

TIGR02680 (5/5) TIGR02680 family protein
TIGR02678 (5/5) TIGR02678 family protein
TIGR02677 (5/5) TIGR02677 family protein
TIGR00484 (5/5) translation elongation factor G
PF14492 (5/5) Elongation Factor G, domain II
PF13558 (5/5) Putative exonuclease SbcCD, C subunit
PF10127 (5/5) RNA repair pathway DNA polymerase beta family
PF09983 (5/5) Uncharacterized protein conserved in bacteria C-term(DUF2220)
PF09661 (5/5) Protein of unknown function (DUF2398)
PF09660 (5/5) Protein of unknown function (DUF2397)
PF03764 (5/5) Elongation factor G, domain IV
PF03144 (5/5) Elongation factor Tu domain 2
PF00679 (5/5) Elongation factor G C-terminus
PF00009 (5/5) Elongation factor Tu GTP binding domain
precursor_jaccard_groups_5027 123.62 +- 97.58 3 0 0 0 0.03 +- 0.03 3 3

PF07702 (3/3) UTRA domain
PF00668 (3/3) Condensation domain
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_14897 112.38 +- 62.86 2 0 1 0 0.06 +- 0.05 2 4

PF01427 (2/2) D-ala-D-ala dipeptidase
PF00293 (2/2) NUDIX domain
PF13671 (1/2) AAA domain
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_27098 832.61 +- 32.46 2 0 2 2 0.03 +- 0.06 2 26

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13581 (2/2) Histidine kinase-like ATPase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF13671 (1/2) AAA domain
PF13599 (1/2) Pentapeptide repeats (9 copies)
PF08242 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01427 (1/2) D-ala-D-ala dipeptidase
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00723 (1/2) Glycosyl hydrolases family 15
precursor_jaccard_groups_10102 47.14 +- 1.98 4 0 0 4 0.10 +- 0.08 4 5

PF13360 (4/4) PQQ-like domain
PF00069 (4/4) Protein kinase domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
PF04185 (3/4) Phosphoesterase family
precursor_jaccard_groups_10103 57.50 +- 6.05 4 0 0 4 0.11 +- 0.12 4 6

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF13565 (4/4) Homeodomain-like domain
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF02954 (4/4) Bacterial regulatory protein, Fis family
PF01590 (4/4) GAF domain
PF00733 (4/4) Asparagine synthase
precursor_jaccard_groups_8515 14.27 +- 0.54 2 0 0 0 0.21 +- 0.34 2 7

TIGR01412 (2/2) Tat-translocated enzyme
PF07987 (2/2) Domain of unkown function (DUF1775)
PF05425 (2/2) Copper resistance protein D
PF04314 (2/2) Copper chaperone PCu(A)C
PF04261 (2/2) Dyp-type peroxidase family
PF04234 (2/2) CopC domain
PF02630 (2/2) SCO1/SenC
precursor_jaccard_groups_37057 153.97 +- 23.06 2 0 2 0 0.09 +- 0.08 2 14

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13489 (2/2) Methyltransferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF08659 (2/2) KR domain
PF07859 (2/2) alpha/beta hydrolase fold
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_37052 676.66 +- 57.46 2 0 0 0 0.02 +- 0.01 2 7

PF07859 (2/2) alpha/beta hydrolase fold
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_29922 1186.17 +- 232.83 2 0 2 2 0.01 +- 0.00 2 13

PF13580 (2/2) SIS domain
PF08544 (2/2) GHMP kinases C terminal
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF01761 (2/2) 3-dehydroquinate synthase
PF01555 (2/2) DNA methylase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01087 (2/2) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00288 (2/2) GHMP kinases N terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_11184 99.55 +- 112.40 3 0 0 0 0.10 +- 0.19 3 5

PF18593 (3/3) CdiI immunity protein
PF18431 (3/3) Bacterial CdiA-CT RNAse A domain
PF13560 (3/3) Helix-turn-helix domain
PF06013 (3/3) Proteins of 100 residues with WXG
PF04149 (3/3) Domain of unknown function (DUF397)
precursor_jaccard_groups_41222 129.00 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF01833 (2/2) IPT/TIG domain
PF01636 (2/2) Phosphotransferase enzyme family
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_12164 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF04978 (2/2) Protein of unknown function (DUF664)
precursor_jaccard_groups_41049 730.56 +- 559.44 2 0 1 0 0.07 +- 0.16 2 16

TIGR04458 (2/2) 4-nitrotryptophan synthase
TIGR00730 (2/2) TIGR00730 family protein
PF13649 (2/2) Methyltransferase domain
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF02898 (2/2) Nitric oxide synthase, oxygenase domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01745 (2/2) Isopentenyl transferase
PF01565 (2/2) FAD binding domain
PF00872 (2/2) Transposase, Mutator family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_37690 324.11 +- 14.51 2 0 2 0 0.02 +- 0.03 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13610 (2/2) DDE domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF02554 (2/2) Carbon starvation protein CstA
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_33379 246.55 +- 29.88 2 0 0 2 0.02 +- 0.00 2 5

PF13847 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
precursor_jaccard_groups_1002 296.64 +- 648.16 17 0 17 0 0.13 +- 0.24 17 10

PF13561 (17/17) Enoyl-(Acyl carrier protein) reductase
PF12697 (17/17) Alpha/beta hydrolase family
PF07977 (17/17) FabA-like domain
PF03621 (17/17) MbtH-like protein
PF01323 (17/17) DSBA-like thioredoxin domain
PF00109 (17/17) Beta-ketoacyl synthase, N-terminal domain
PF02801 (14/17) Beta-ketoacyl synthase, C-terminal domain
PF00550 (14/17) Phosphopantetheine attachment site
TIGR01830 (10/17) 3-oxoacyl-[acyl-carrier-protein] reductase
PF00975 (9/17) Thioesterase domain
precursor_jaccard_groups_1003 474.85 +- 555.56 25 0 25 0 0.06 +- 0.15 25 14

TIGR01733 (25/25) amino acid adenylation domain
PF13193 (25/25) AMP-binding enzyme C-terminal domain
PF07690 (25/25) Major Facilitator Superfamily
PF06368 (25/25) Methylaspartate mutase E chain (MutE)
PF03621 (25/25) MbtH-like protein
PF02310 (25/25) B12 binding domain
PF01645 (25/25) Conserved region in glutamate synthase
PF00975 (25/25) Thioesterase domain
PF00668 (25/25) Condensation domain
PF00550 (25/25) Phosphopantetheine attachment site
PF00501 (25/25) AMP-binding enzyme
PF00152 (25/25) tRNA synthetases class II (D, K and N)
PF01648 (23/25) 4'-phosphopantetheinyl transferase superfamily
PF02668 (16/25) Taurine catabolism dioxygenase TauD, TfdA family
precursor_jaccard_groups_27076 759.33 +- 76.39 2 0 0 0 0.01 +- 0.00 2 7

PF16375 (2/2) Domain of unknown function
PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF04616 (2/2) Glycosyl hydrolases family 43
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_20029 449.33 +- 47.14 3 0 0 0 0.01 +- 0.00 3 6

PF17939 (3/3) Tetracyclin repressor-like, C-terminal domain
PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07859 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_7971 47.44 +- 14.97 6 0 0 6 0.08 +- 0.10 6 6

TIGR01536 (6/6) asparagine synthase (glutamine-hydrolyzing)
PF13622 (6/6) Thioesterase-like superfamily
PF13537 (6/6) Glutamine amidotransferase domain
PF07690 (6/6) Major Facilitator Superfamily
PF01425 (6/6) Amidase
PF00733 (6/6) Asparagine synthase
precursor_jaccard_groups_7977 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_19467 757.46 +- 843.88 3 0 0 0 0.09 +- 0.19 3 15

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00248 (3/3) Aldo/keto reductase family
PF00005 (3/3) ABC transporter
PF07920 (2/3) Protein of unknown function (DUF1684)
PF07690 (2/3) Major Facilitator Superfamily
PF05922 (2/3) Peptidase inhibitor I9
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00082 (2/3) Subtilase family
precursor_jaccard_groups_10218 11.68 +- 2.92 2 0 0 0 0.22 +- 0.23 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_10210 84.15 +- 89.10 5 0 4 0 0.06 +- 0.07 5 2

PF01510 (5/5) N-acetylmuramoyl-L-alanine amidase
PF01183 (5/5) Glycosyl hydrolases family 25
precursor_jaccard_groups_1644 214.96 +- 102.76 4 0 4 0 0.04 +- 0.04 4 5

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01946 (3/4) Thi4 family
precursor_jaccard_groups_1313 435.72 +- 307.47 24 0 20 0 0.03 +- 0.04 24 6

PF13193 (24/24) AMP-binding enzyme C-terminal domain
PF01959 (24/24) 3-dehydroquinate synthase II
PF01791 (24/24) DeoC/LacD family aldolase
PF01494 (24/24) FAD binding domain
PF00501 (24/24) AMP-binding enzyme
TIGR03892 (18/24) thiazolylpeptide-type bacteriocin precursor
precursor_jaccard_groups_1315 20.61 +- 16.38 9 0 0 0 0.20 +- 0.36 9 6

PF12806 (9/9) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (9/9) Acyl-CoA dehydrogenase N terminal
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF00775 (9/9) Dioxygenase
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF13641 (8/9) Glycosyltransferase like family 2
precursor_jaccard_groups_19512 286.05 +- 74.48 3 0 3 0 0.01 +- 0.00 3 5

PF13535 (3/3) ATP-grasp domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF05960 (3/3) Bacterial protein of unknown function (DUF885)
PF02195 (3/3) ParB-like nuclease domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_8196 273.59 +- 115.10 6 0 0 0 0.03 +- 0.01 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_jaccard_groups_9861 480.08 +- 238.08 3 0 0 0 0.07 +- 0.14 3 11

TIGR01426 (3/3) glycosyltransferase, MGT family
PF13546 (3/3) DDE superfamily endonuclease
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (3/3) Pretoxin HINT domain
PF04471 (3/3) Restriction endonuclease
PF03752 (3/3) Short repeats of unknown function
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF00535 (3/3) Glycosyl transferase family 2
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00089 (3/3) Trypsin
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_9864 71.12 +- 20.64 2 0 0 0 0.04 +- 0.03 2 7

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00484 (2/2) Carbonic anhydrase
PF00072 (2/2) Response regulator receiver domain
PF00916 (1/2) Sulfate permease family
precursor_jaccard_groups_38006 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_18938 117.78 +- 28.47 2 0 2 0 0.02 +- 0.02 2 6

PF18741 (2/2) REase_MTES_1575
PF13545 (2/2) Crp-like helix-turn-helix domain
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02342 (2/2) TerD domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_9868 9.28 +- 0.62 4 0 0 0 0.22 +- 0.16 4 3

PF13649 (4/4) Methyltransferase domain
PF07883 (4/4) Cupin domain
PF01381 (4/4) Helix-turn-helix
precursor_jaccard_groups_5155 190.08 +- 61.70 7 0 7 7 0.01 +- 0.00 7 4

TIGR03891 (7/7) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF05147 (7/7) Lanthionine synthetase C-like protein
PF04738 (7/7) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_14906 256.07 +- 76.34 4 0 0 0 0.02 +- 0.01 4 2

PF01757 (4/4) Acyltransferase family
PF01522 (4/4) Polysaccharide deacetylase
precursor_jaccard_groups_21480 193.01 +- 38.01 3 0 3 0 0.09 +- 0.20 3 25

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF13649 (3/3) Methyltransferase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08281 (3/3) Sigma-70, region 4
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF03824 (3/3) High-affinity nickel-transport protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_21482 316.69 +- 87.47 3 0 0 0 0.04 +- 0.03 3 10

PF15979 (3/3) Glycosyl hydrolase family 115
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00877 (3/3) NlpC/P60 family
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF17829 (2/3) Gylcosyl hydrolase family 115 C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_19995 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_35355 78.08 +- 11.23 2 0 0 0 0.04 +- 0.03 2 5

TIGR03889 (2/2) nitrile hydratase accessory protein
TIGR03888 (2/2) nitrile hydratase, beta subunit
TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
precursor_jaccard_groups_19998 23.27 +- 3.11 3 0 0 0 0.09 +- 0.08 3 3

PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00457 (3/3) Glycosyl hydrolases family 11
PF00331 (3/3) Glycosyl hydrolase family 10
precursor_jaccard_groups_11311 21.98 +- 5.92 3 0 0 0 0.10 +- 0.06 3 5

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_13988 60.74 +- 9.60 4 0 4 0 0.07 +- 0.03 4 10

TIGR01733 (4/4) amino acid adenylation domain
PF14681 (4/4) Uracil phosphoribosyltransferase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF04227 (4/4) Indigoidine synthase A like protein
PF01361 (4/4) Tautomerase enzyme
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
TIGR01549 (3/4) HAD hydrolase, family IA, variant 1
precursor_jaccard_groups_35424 72.56 +- 4.84 2 0 2 0 0.10 +- 0.21 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_22609 32.67 +- 14.24 2 0 0 0 0.11 +- 0.19 2 10

PF07690 (2/2) Major Facilitator Superfamily
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00108 (2/2) Thiolase, N-terminal domain
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF07591 (1/2) Pretoxin HINT domain
precursor_jaccard_groups_30275 286.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF05729 (1/2) NACHT domain
precursor_jaccard_groups_30270 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_jaccard_groups_21158 79.55 +- 23.01 3 0 3 0 0.06 +- 0.06 3 9

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF11512 (3/3) Agrobacterium tumefaciens protein Atu4866
PF07690 (3/3) Major Facilitator Superfamily
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF13480 (2/3) Acetyltransferase (GNAT) domain
PF00155 (2/3) Aminotransferase class I and II
precursor_jaccard_groups_22599 327.62 +- 23.17 3 0 0 0 0.01 +- 0.01 3 6

PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF03466 (3/3) LysR substrate binding domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00884 (3/3) Sulfatase
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_11278 275.73 +- 48.75 4 0 0 0 0.03 +- 0.03 4 12

PF13977 (4/4) BetI-type transcriptional repressor, C-terminal
PF13607 (4/4) Succinyl-CoA ligase like flavodoxin domain
PF13549 (4/4) ATP-grasp domain
PF13380 (4/4) CoA binding domain
PF13279 (4/4) Thioesterase-like superfamily
PF07729 (4/4) FCD domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_27676 388.50 +- 1.50 2 0 0 0 0.01 +- 0.00 2 6

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_22287 1034.67 +- 3.77 3 0 3 0 0.01 +- 0.00 3 17

TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08242 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00155 (3/3) Aminotransferase class I and II
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_11073 71.19 +- 45.70 3 0 0 0 0.05 +- 0.06 3 1

PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_38452 26.80 +- 1.64 2 0 0 2 0.15 +- 0.24 2 11

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14404 (2/2) Ribosomally synthesized peptide in Streptomyces species
PF13405 (2/2) EF-hand domain
PF13202 (2/2) EF hand
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF09471 (2/2) IgA Peptidase M64
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01593 (2/2) Flavin containing amine oxidoreductase
PF13833 (1/2) EF-hand domain pair
PF13499 (1/2) EF-hand domain pair
precursor_jaccard_groups_10389 129.38 +- 72.75 5 0 0 5 0.05 +- 0.10 5 5

TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
PF13537 (5/5) Glutamine amidotransferase domain
PF00797 (5/5) N-acetyltransferase
PF00733 (5/5) Asparagine synthase
PF00135 (5/5) Carboxylesterase family
precursor_jaccard_groups_25814 9.87 +- 0.59 2 0 0 0 0.20 +- 0.28 2 2

PF02156 (2/2) Glycosyl hydrolase family 26
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_9911 16.52 +- 1.04 2 0 0 0 0.18 +- 0.34 2 6

TIGR04037 (2/2) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (2/2) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF03358 (2/2) NADPH-dependent FMN reductase
PF00582 (2/2) Universal stress protein family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_4011 324.79 +- 118.13 10 0 10 10 0.02 +- 0.02 10 3

PF13471 (10/10) Transglutaminase-like superfamily
PF00733 (10/10) Asparagine synthase
PF00005 (10/10) ABC transporter
precursor_jaccard_groups_592 22.51 +- 20.25 18 0 0 0 0.20 +- 0.37 18 7

PF13517 (18/18) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF07859 (18/18) alpha/beta hydrolase fold
PF07730 (18/18) Histidine kinase
PF01839 (18/18) FG-GAP repeat
PF00196 (18/18) Bacterial regulatory proteins, luxR family
PF00072 (18/18) Response regulator receiver domain
PF13460 (15/18) NAD(P)H-binding
precursor_jaccard_groups_4016 33.73 +- 9.33 8 0 8 0 0.21 +- 0.20 8 8

PF11991 (8/8) Tryptophan dimethylallyltransferase
PF05331 (8/8) Protein of unknown function (DUF742)
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF02518 (8/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (8/8) Beta-eliminating lyase
PF00664 (8/8) ABC transporter transmembrane region
PF00005 (8/8) ABC transporter
precursor_jaccard_groups_37472 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_37471 403.22 +- 4.70 2 0 0 0 0.03 +- 0.01 2 10

PF10935 (2/2) Protein of unknown function (DUF2637)
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF13144 (1/2) Chaperone for flagella basal body P-ring formation
PF08666 (1/2) SAF domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_44502 46.94 +- 3.06 2 0 0 0 0.11 +- 0.26 2 8

TIGR03445 (2/2) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01817 (2/2) Chorismate mutase type II
PF01425 (2/2) Amidase
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_8063 297.39 +- 131.92 6 0 1 0 0.02 +- 0.02 6 5

PF13404 (6/6) AsnC-type helix-turn-helix domain
PF07969 (6/6) Amidohydrolase family
PF02133 (6/6) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01037 (6/6) Lrp/AsnC ligand binding domain
PF00583 (6/6) Acetyltransferase (GNAT) family
precursor_jaccard_groups_28856 12.27 +- 1.66 2 0 0 0 0.17 +- 0.23 2 4

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF07883 (2/2) Cupin domain
PF01609 (2/2) Transposase DDE domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_17608 18.05 +- 3.84 3 0 0 0 0.19 +- 0.29 3 5

PF05685 (3/3) Putative restriction endonuclease
PF04149 (3/3) Domain of unknown function (DUF397)
PF00067 (3/3) Cytochrome P450
PF13560 (2/3) Helix-turn-helix domain
PF13302 (2/3) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_15709 264.25 +- 23.13 3 0 0 0 0.03 +- 0.02 3 7

PF13814 (3/3) Replication-relaxation
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_jaccard_groups_38844 45.17 +- 4.18 2 0 0 0 0.22 +- 0.22 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05175 (2/2) Methyltransferase small domain
PF04016 (2/2) Putative heavy-metal chelation
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_21737 790.12 +- 159.63 3 0 3 0 0.01 +- 0.01 3 11

TIGR01490 (3/3) HAD hydrolase, family IB
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF05655 (3/3) Pseudomonas avirulence D protein (AvrD)
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00975 (3/3) Thioesterase domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_17446 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_jaccard_groups_8148 134.53 +- 90.94 3 0 0 0 0.03 +- 0.04 3 2

PF08877 (3/3) MepB protein
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_25921 23.30 +- 0.70 2 0 0 0 0.13 +- 0.15 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_jaccard_groups_8066 609.67 +- 386.30 6 0 6 6 0.05 +- 0.14 6 11

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (6/6) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (6/6) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (6/6) SagB-type dehydrogenase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (6/6) HlyD family secretion protein
PF03412 (6/6) Peptidase C39 family
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/6) Nitroreductase family
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_22912 181.52 +- 36.96 3 0 1 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_5838 103.24 +- 52.77 8 0 8 0 0.03 +- 0.01 8 4

TIGR01509 (8/8) HAD hydrolase, family IA, variant 3
PF03756 (8/8) A-factor biosynthesis hotdog domain
PF00702 (8/8) haloacid dehalogenase-like hydrolase
PF00067 (8/8) Cytochrome P450
precursor_jaccard_groups_30584 15.20 +- 5.33 2 0 2 0 0.15 +- 0.16 2 3

TIGR02434 (2/2) precorrin-6A synthase (deacetylating)
PF03745 (2/2) Domain of unknown function (DUF309)
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
precursor_jaccard_groups_29587 38.91 +- 7.53 2 0 0 0 0.08 +- 0.05 2 4

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_30588 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_5835 43.50 +- 23.93 5 0 0 0 0.19 +- 0.19 5 9

TIGR00505 (5/5) GTP cyclohydrolase II
PF03706 (5/5) Lysylphosphatidylglycerol synthase TM region
PF01242 (5/5) 6-pyruvoyl tetrahydropterin synthase
PF00925 (5/5) GTP cyclohydrolase II
PF00534 (5/5) Glycosyl transferases group 1
PF16653 (4/5) Saccharopine dehydrogenase C-terminal domain
PF05222 (4/5) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (4/5) Saccharopine dehydrogenase NADP binding domain
PF01266 (4/5) FAD dependent oxidoreductase
precursor_jaccard_groups_8730 37.81 +- 15.94 2 0 2 0 0.21 +- 0.22 2 8

PF14310 (2/2) Fibronectin type III-like domain
PF09362 (2/2) Domain of unknown function (DUF1996)
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00754 (2/2) F5/8 type C domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_21027 27.87 +- 13.97 3 0 0 0 0.10 +- 0.11 3 3

TIGR03696 (3/3) RHS repeat-associated core domain
PF04672 (3/3) S-adenosyl methyltransferase
PF01636 (3/3) Phosphotransferase enzyme family
precursor_jaccard_groups_4810 2014.89 +- 824.36 9 0 1 0 0.01 +- 0.01 9 12

PF13560 (9/9) Helix-turn-helix domain
PF13393 (9/9) Histidyl-tRNA synthetase
PF03721 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01370 (9/9) NAD dependent epimerase/dehydratase family
PF01061 (9/9) ABC-2 type transporter
PF00984 (9/9) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00005 (9/9) ABC transporter
PF17874 (8/9) MalT-like TPR region
PF05193 (8/9) Peptidase M16 inactive domain
PF00675 (8/9) Insulinase (Peptidase family M16)
precursor_jaccard_groups_3468 68.72 +- 13.29 4 0 0 2 0.07 +- 0.08 4 19

PF14325 (4/4) Domain of unknown function (DUF4383)
PF00106 (4/4) short chain dehydrogenase
TIGR01828 (3/4) pyruvate, phosphate dikinase
PF02896 (3/4) PEP-utilising enzyme, TIM barrel domain
PF02607 (3/4) B12 binding domain
PF01326 (3/4) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00582 (3/4) Universal stress protein family
PF00391 (3/4) PEP-utilising enzyme, mobile domain
TIGR02493 (2/4) pyruvate formate-lyase 1-activating enzyme
TIGR01534 (2/4) glyceraldehyde-3-phosphate dehydrogenase, type I
TIGR01255 (2/4) formate acetyltransferase
PF13411 (2/4) MerR HTH family regulatory protein
PF04055 (2/4) Radical SAM superfamily
PF02901 (2/4) Pyruvate formate lyase-like
PF02800 (2/4) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01228 (2/4) Glycine radical
PF00465 (2/4) Iron-containing alcohol dehydrogenase
PF00171 (2/4) Aldehyde dehydrogenase family
PF00044 (2/4) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_3466 18.28 +- 2.03 2 0 0 0 0.16 +- 0.20 2 7

PF13280 (2/2) WYL domain
PF11720 (2/2) Peptidase inhibitor I78 family
PF08279 (2/2) HTH domain
PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
PF13439 (1/2) Glycosyltransferase Family 4
PF00534 (1/2) Glycosyl transferases group 1
precursor_jaccard_groups_29218 1649.38 +- 170.62 2 0 1 0 0.01 +- 0.00 2 12

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF11706 (2/2) CGNR zinc finger
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07336 (2/2) Putative stress-induced transcription regulator
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF04854 (2/2) Protein of unknown function, DUF624
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00532 (2/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_25039 277.15 +- 78.93 2 0 0 0 0.04 +- 0.06 2 10

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_jaccard_groups_24035 57.11 +- 1.39 2 0 2 0 0.05 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05675 (2/2) Protein of unknown function (DUF817)
PF01810 (2/2) LysE type translocator
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_39122 439.83 +- 15.17 2 0 2 0 0.02 +- 0.01 2 8

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12832 (2/2) MFS_1 like family
PF01212 (2/2) Beta-eliminating lyase
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00156 (2/2) Phosphoribosyl transferase domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_627 409.74 +- 276.60 6 0 6 6 0.06 +- 0.20 6 7

TIGR04364 (6/6) methyltransferase, FxLD system
TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF01135 (6/6) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
TIGR04363 (4/6) FxLD family lantipeptide
precursor_jaccard_groups_17932 191.78 +- 19.93 3 0 0 0 0.13 +- 0.24 3 14

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00223 (3/3) aspartate 1-decarboxylase
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02261 (3/3) Aspartate decarboxylase
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
PF14498 (2/3) Glycosyl hydrolase family 65, N-terminal domain
precursor_jaccard_groups_29213 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 6

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF11706 (2/2) CGNR zinc finger
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
precursor_jaccard_groups_17936 30.66 +- 3.29 2 0 0 2 0.13 +- 0.06 2 6

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05141 (2/2) Pyoverdine/dityrosine biosynthesis protein
PF00733 (2/2) Asparagine synthase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_5944 292.86 +- 73.14 7 0 7 7 0.01 +- 0.00 7 4

PF13471 (7/7) Transglutaminase-like superfamily
PF05402 (7/7) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (7/7) Asparagine synthase
PF00480 (7/7) ROK family
precursor_jaccard_groups_40406 367.65 +- 174.15 2 0 0 0 0.02 +- 0.02 2 10

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07366 (2/2) SnoaL-like polyketide cyclase
PF04978 (2/2) Protein of unknown function (DUF664)
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF12146 (1/2) Serine aminopeptidase, S33
precursor_jaccard_groups_5943 764.64 +- 456.88 4 0 4 0 0.04 +- 0.12 4 5

PF13649 (4/4) Methyltransferase domain
PF12697 (4/4) Alpha/beta hydrolase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01593 (3/4) Flavin containing amine oxidoreductase
precursor_jaccard_groups_29452 147.43 +- 110.57 2 0 0 0 0.03 +- 0.05 2 3

PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00107 (2/2) Zinc-binding dehydrogenase
PF14667 (1/2) Polysaccharide biosynthesis C-terminal domain
precursor_jaccard_groups_29102 175.06 +- 37.41 2 0 0 0 0.03 +- 0.04 2 9

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_28292 193.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 4

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_13103 28.89 +- 0.00 2 0 2 0 0.07 +- 0.04 2 4

PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01565 (2/2) FAD binding domain
precursor_jaccard_groups_16467 94.87 +- 115.35 3 0 0 0 0.10 +- 0.11 3 3

PF07702 (3/3) UTRA domain
PF04672 (3/3) S-adenosyl methyltransferase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_28294 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_22826 74.74 +- 20.34 3 0 0 0 0.09 +- 0.11 3 5

PF08241 (3/3) Methyltransferase domain
PF05711 (3/3) Macrocin-O-methyltransferase (TylF)
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
precursor_jaccard_groups_30294 22.87 +- 1.20 2 0 0 0 0.20 +- 0.17 2 23

TIGR03346 (2/2) ATP-dependent chaperone protein ClpB
TIGR02350 (2/2) chaperone protein DnaK
TIGR01068 (2/2) thioredoxin
PF17871 (2/2) AAA lid domain
PF13591 (2/2) MerR HTH family regulatory protein
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF02148 (2/2) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (2/2) DnaJ C terminal domain
PF01025 (2/2) GrpE
PF00226 (2/2) DnaJ domain
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00012 (2/2) Hsp70 protein
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
TIGR00630 (1/2) excinuclease ABC subunit A
PF17755 (1/2) UvrA DNA-binding domain
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
PF01411 (1/2) tRNA synthetases class II (A)
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_15990 426.92 +- 330.10 3 0 3 3 0.01 +- 0.01 3 5

PF08007 (3/3) Cupin superfamily protein
PF07690 (3/3) Major Facilitator Superfamily
PF05114 (3/3) Protein of unknown function (DUF692)
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
precursor_jaccard_groups_26858 174.69 +- 44.69 2 0 0 0 0.06 +- 0.02 2 4

PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_10583 37.02 +- 9.98 5 0 0 0 0.14 +- 0.26 5 10

PF14542 (5/5) GCN5-related N-acetyl-transferase
PF12802 (5/5) MarR family
PF07690 (5/5) Major Facilitator Superfamily
PF05726 (5/5) Pirin C-terminal cupin domain
PF02678 (5/5) Pirin
PF01326 (5/5) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00089 (5/5) Trypsin
TIGR04036 (4/5) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF14559 (4/5) Tetratricopeptide repeat
PF00296 (4/5) Luciferase-like monooxygenase
precursor_jaccard_groups_13807 782.71 +- 351.28 4 0 0 0 0.03 +- 0.04 4 11

PF18099 (4/4) DUF5010 C-terminal domain
PF13377 (4/4) Periplasmic binding protein-like domain
PF11941 (4/4) Domain of unknown function (DUF3459)
PF10756 (4/4) Bacterial PH domain
PF03663 (4/4) Glycosyl hydrolase family 76
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00128 (4/4) Alpha amylase, catalytic domain
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (3/4) Dehydratase family
precursor_jaccard_groups_3796 858.02 +- 420.18 9 0 2 0 0.02 +- 0.01 9 10

TIGR00710 (9/9) drug resistance transporter, Bcr/CflA subfamily
PF07690 (9/9) Major Facilitator Superfamily
PF03737 (9/9) Aldolase/RraA
PF03466 (9/9) LysR substrate binding domain
PF01361 (9/9) Tautomerase enzyme
PF00994 (9/9) Probable molybdopterin binding domain
PF00682 (9/9) HMGL-like
PF00180 (9/9) Isocitrate/isopropylmalate dehydrogenase
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
PF00890 (5/9) FAD binding domain
precursor_jaccard_groups_37594 109.51 +- 1.92 2 0 0 0 0.04 +- 0.03 2 6

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_38554 72.29 +- 2.49 2 0 0 0 0.14 +- 0.30 2 11

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF16864 (2/2) Dimerisation domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF07690 (2/2) Major Facilitator Superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_24727 580.50 +- 193.50 2 0 0 0 0.01 +- 0.01 2 5

PF13577 (2/2) SnoaL-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF01638 (1/2) HxlR-like helix-turn-helix
precursor_jaccard_groups_24726 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_28276 337.77 +- 33.50 2 0 2 0 0.21 +- 0.29 2 29

TIGR02246 (2/2) conserved hypothetical protein
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF12051 (2/2) Protein of unknown function (DUF3533)
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/2) Histidine kinase
PF04673 (2/2) Polyketide synthesis cyclase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00483 (2/2) Nucleotidyl transferase
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_40371 15.41 +- 2.73 2 0 0 0 0.13 +- 0.13 2 5

PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_jaccard_groups_3447 69.39 +- 8.93 7 0 0 0 0.15 +- 0.06 7 6

PF13416 (7/7) Bacterial extracellular solute-binding protein
PF13377 (7/7) Periplasmic binding protein-like domain
PF01204 (7/7) Trehalase
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00356 (7/7) Bacterial regulatory proteins, lacI family
PF13649 (6/7) Methyltransferase domain
precursor_jaccard_groups_41969 433.58 +- 275.92 2 0 0 0 0.04 +- 0.03 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4325 104.00 +- 0.00 2 0 0 0 0.04 +- 0.02 2 3

PF08445 (2/2) FR47-like protein
PF04326 (2/2) Putative DNA-binding domain
PF03235 (2/2) Protein of unknown function DUF262
precursor_jaccard_groups_13039 103.19 +- 52.98 4 0 0 0 0.02 +- 0.03 4 2

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF01243 (4/4) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_44237 271.23 +- 126.83 2 0 2 0 0.13 +- 0.29 2 23

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF14759 (2/2) Reductase C-terminal
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08241 (2/2) Methyltransferase domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07977 (2/2) FabA-like domain
PF04073 (2/2) Aminoacyl-tRNA editing domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01323 (2/2) DSBA-like thioredoxin domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
precursor_jaccard_groups_4943 250.81 +- 122.24 9 0 9 0 0.12 +- 0.25 9 32

TIGR01902 (9/9) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (9/9) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (9/9) amino acid adenylation domain
TIGR00768 (9/9) alpha-L-glutamate ligase, RimK family
PF18603 (9/9) L-amino acid ligase C-terminal domain 2
PF18130 (9/9) ATP-grasp N-terminal domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF14765 (9/9) Polyketide synthase dehydratase
PF13602 (9/9) Zinc-binding dehydrogenase
PF13535 (9/9) ATP-grasp domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF08990 (9/9) Erythronolide synthase docking
PF08659 (9/9) KR domain
PF08443 (9/9) RimK-like ATP-grasp domain
PF08028 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF03992 (9/9) Antibiotic biosynthesis monooxygenase
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF02779 (9/9) Transketolase, pyrimidine binding domain
PF01546 (9/9) Peptidase family M20/M25/M40
PF01370 (9/9) NAD dependent epimerase/dehydratase family
PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (9/9) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (9/9) Thioesterase domain
PF00698 (9/9) Acyl transferase domain
PF00696 (9/9) Amino acid kinase family
PF00668 (9/9) Condensation domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00456 (9/9) Transketolase, thiamine diphosphate binding domain
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF08240 (7/9) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_6846 18.55 +- 5.04 6 0 0 0 0.19 +- 0.36 6 9

TIGR00465 (6/6) ketol-acid reductoisomerase
PF12902 (6/6) Ferritin-like
PF08281 (6/6) Sigma-70, region 4
PF07991 (6/6) Acetohydroxy acid isomeroreductase, NADPH-binding domain
PF04542 (6/6) Sigma-70 region 2
PF01450 (6/6) Acetohydroxy acid isomeroreductase, catalytic domain
PF00903 (6/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF13191 (3/6) AAA ATPase domain
precursor_jaccard_groups_30125 74.81 +- 28.39 2 0 2 2 0.06 +- 0.04 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_31181 269.54 +- 250.46 2 0 0 0 0.11 +- 0.27 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00481 (2/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF07690 (2/2) Major Facilitator Superfamily
PF01161 (2/2) Phosphatidylethanolamine-binding protein
PF00857 (2/2) Isochorismatase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_23563 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_18389 62.55 +- 5.10 3 0 2 0 0.22 +- 0.26 3 16

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (3/3) FCD domain
PF05544 (3/3) Proline racemase
PF04324 (3/3) BFD-like [2Fe-2S] binding domain
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_1197 60.92 +- 21.76 12 0 0 0 0.21 +- 0.28 12 7

TIGR03860 (12/12) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (12/12) FAD-NAD(P)-binding
PF07920 (12/12) Protein of unknown function (DUF1684)
PF00296 (12/12) Luciferase-like monooxygenase
PF02983 (10/12) Alpha-lytic protease prodomain
PF01145 (10/12) SPFH domain / Band 7 family
PF00089 (10/12) Trypsin
precursor_jaccard_groups_40974 366.83 +- 20.17 2 0 2 0 0.01 +- 0.01 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_34979 470.31 +- 131.69 2 0 2 0 0.03 +- 0.07 2 12

TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF05199 (2/2) GMC oxidoreductase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00732 (2/2) GMC oxidoreductase
PF00664 (2/2) ABC transporter transmembrane region
PF00483 (2/2) Nucleotidyl transferase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_34972 191.33 +- 9.33 2 0 0 0 0.01 +- 0.01 2 3

PF13560 (2/2) Helix-turn-helix domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_jaccard_groups_3645 43.36 +- 36.39 3 0 0 0 0.14 +- 0.23 3 10

TIGR00589 (3/3) methylated-DNA--[protein]-cysteine S-methyltransferase
PF13532 (3/3) 2OG-Fe(II) oxygenase superfamily
PF12728 (3/3) Helix-turn-helix domain
PF12307 (3/3) Protein of unknown function (DUF3631)
PF09250 (3/3) Bifunctional DNA primase/polymerase, N-terminal
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF11750 (2/3) Protein of unknown function (DUF3307)
PF10935 (2/3) Protein of unknown function (DUF2637)
PF04461 (2/3) Protein of unknown function (DUF520)
PF00589 (2/3) Phage integrase family
precursor_jaccard_groups_28720 33.95 +- 0.00 2 0 0 0 0.15 +- 0.32 2 9

TIGR00193 (2/2) urease, gamma subunit
TIGR00192 (2/2) urease, beta subunit
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF01979 (2/2) Amidohydrolase family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_34576 73.71 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR01472 (2/2) GDP-mannose 4,6-dehydratase
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13641 (2/2) Glycosyltransferase like family 2
PF05050 (2/2) Methyltransferase FkbM domain
PF04932 (2/2) O-Antigen ligase
precursor_jaccard_groups_3867 403.67 +- 214.34 10 0 0 0 0.04 +- 0.05 10 7

PF13531 (10/10) Bacterial extracellular solute-binding protein
PF08402 (10/10) TOBE domain
PF00694 (10/10) Aconitase C-terminal domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00005 (10/10) ABC transporter
PF08445 (5/10) FR47-like protein
PF00106 (5/10) short chain dehydrogenase
precursor_jaccard_groups_3869 13.66 +- 4.77 2 0 2 0 0.17 +- 0.16 2 1

PF00756 (2/2) Putative esterase
precursor_jaccard_groups_9877 2193.23 +- 1659.28 5 0 5 5 0.04 +- 0.10 5 10

TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF04072 (5/5) Leucine carboxyl methyltransferase
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (5/5) CPBP intramembrane metalloprotease
PF01061 (5/5) ABC-2 type transporter
PF00881 (5/5) Nitroreductase family
PF00005 (5/5) ABC transporter
TIGR00027 (4/5) methyltransferase, TIGR00027 family
PF00149 (4/5) Calcineurin-like phosphoesterase
precursor_jaccard_groups_3319 42.96 +- 9.04 2 0 0 0 0.05 +- 0.04 2 3

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13783 (2/2) Domain of unknown function (DUF4177)
PF01120 (2/2) Alpha-L-fucosidase
precursor_jaccard_groups_13350 635.87 +- 315.27 4 0 0 0 0.04 +- 0.01 4 13

PF17189 (4/4) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (4/4) Fibronectin type III-like domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF13377 (4/4) Periplasmic binding protein-like domain
PF08244 (4/4) Glycosyl hydrolases family 32 C terminal
PF02055 (4/4) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (4/4) IPT/TIG domain
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00754 (4/4) F5/8 type C domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00251 (4/4) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_13351 2023.52 +- 1169.56 4 0 0 0 0.03 +- 0.09 4 20

PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13692 (4/4) Glycosyl transferases group 1
PF13489 (4/4) Methyltransferase domain
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF12708 (4/4) Pectate lyase superfamily protein
PF04101 (4/4) Glycosyltransferase family 28 C-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02566 (4/4) OsmC-like protein
PF01979 (4/4) Amidohydrolase family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00664 (4/4) ABC transporter transmembrane region
PF00155 (4/4) Aminotransferase class I and II
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
TIGR01179 (3/4) UDP-glucose 4-epimerase GalE
PF16363 (3/4) GDP-mannose 4,6 dehydratase
PF07883 (3/4) Cupin domain
PF13641 (2/4) Glycosyltransferase like family 2
PF03704 (2/4) Bacterial transcriptional activator domain
PF00486 (2/4) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_42718 13.25 +- 0.25 2 0 2 0 0.15 +- 0.12 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
precursor_jaccard_groups_41453 29.47 +- 3.47 2 0 0 0 0.10 +- 0.09 2 4

TIGR01412 (2/2) Tat-translocated enzyme
PF09375 (2/2) Imelysin
PF04261 (2/2) Dyp-type peroxidase family
PF04185 (2/2) Phosphoesterase family
precursor_jaccard_groups_13354 110.74 +- 20.91 4 0 0 0 0.07 +- 0.04 4 12

TIGR03570 (4/4) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03025 (4/4) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF17836 (4/4) PglD N-terminal domain
PF13313 (4/4) Domain of unknown function (DUF4082)
PF13205 (4/4) Bacterial Ig-like domain
PF02397 (4/4) Bacterial sugar transferase
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (4/4) Glycosyl transferase family 2
PF03404 (3/4) Mo-co oxidoreductase dimerisation domain
PF00132 (3/4) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_3081 171.70 +- 129.89 6 0 0 0 0.07 +- 0.15 6 3

PF08445 (6/6) FR47-like protein
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00005 (3/6) ABC transporter
precursor_jaccard_groups_2220 56.54 +- 25.80 5 0 0 0 0.10 +- 0.09 5 5

PF04149 (5/5) Domain of unknown function (DUF397)
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family
PF13411 (3/5) MerR HTH family regulatory protein
PF00248 (3/5) Aldo/keto reductase family
precursor_jaccard_groups_39229 147.49 +- 19.43 2 0 0 2 0.17 +- 0.22 2 20

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (2/2) formate acetyltransferase
TIGR00886 (2/2) nitrite transporter
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01228 (2/2) Glycine radical
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
TIGR02374 (1/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (1/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (1/2) Rieske-like [2Fe-2S] domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF03460 (1/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (1/2) Nitrite and sulphite reductase 4Fe-4S domain
precursor_jaccard_groups_10731 606.68 +- 103.68 5 0 1 0 0.01 +- 0.01 5 6

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
precursor_jaccard_groups_43398 476.58 +- 25.08 2 0 0 0 0.01 +- 0.02 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF01614 (2/2) Bacterial transcriptional regulator
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_27121 396.06 +- 136.06 2 0 0 0 0.02 +- 0.02 2 9

TIGR00784 (2/2) citrate transporter
PF17874 (2/2) MalT-like TPR region
PF13649 (2/2) Methyltransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03600 (2/2) Citrate transporter
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_32501 135.86 +- 49.86 2 0 0 0 0.03 +- 0.04 2 4

PF05653 (2/2) Magnesium transporter NIPA
PF03576 (2/2) Peptidase family S58
PF01494 (2/2) FAD binding domain
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_38935 161.20 +- 98.80 2 0 0 0 0.02 +- 0.04 2 6

PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_91 68.71 +- 48.53 256 0 41 256 0.17 +- 0.11 256 8

PF08530 (256/256) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (256/256) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR00976 (255/256) hydrolase CocE/NonD family protein
PF02129 (255/256) X-Pro dipeptidyl-peptidase (S15 family)
PF00005 (255/256) ABC transporter
PF01032 (251/256) FecCD transport family
PF01497 (248/256) Periplasmic binding protein
PF00664 (229/256) ABC transporter transmembrane region
precursor_jaccard_groups_32507 35.30 +- 20.41 2 0 2 0 0.09 +- 0.14 2 4

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (2/2) Phosphopantetheine attachment site
precursor_jaccard_groups_35228 50.89 +- 7.89 2 0 2 0 0.09 +- 0.13 2 7

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF18844 (2/2) Bacterial archaeo-eukaryotic release factor family 2
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00384 (2/2) Molybdopterin oxidoreductase
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10990 (1/2) Protein of unknown function (DUF2809)
PF00795 (1/2) Carbon-nitrogen hydrolase
precursor_jaccard_groups_7528 15.09 +- 4.84 4 0 0 0 0.16 +- 0.16 4 3

PF08546 (4/4) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (4/4) Ketopantoate reductase PanE/ApbA
PF01568 (4/4) Molydopterin dinucleotide binding domain
precursor_jaccard_groups_31982 711.18 +- 425.39 2 0 2 0 0.04 +- 0.09 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12261 (2/2) Thermostable hemolysin
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07977 (2/2) FabA-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF01593 (1/2) Flavin containing amine oxidoreductase
precursor_jaccard_groups_39531 35.50 +- 2.45 2 0 0 0 0.08 +- 0.08 2 5

TIGR01412 (2/2) Tat-translocated enzyme
PF09375 (2/2) Imelysin
PF04261 (2/2) Dyp-type peroxidase family
PF04185 (2/2) Phosphoesterase family
PF14040 (1/2) Deoxyribonuclease NucA/NucB
precursor_jaccard_groups_32436 476.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 3

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_35422 25.20 +- 1.80 2 0 0 0 0.12 +- 0.09 2 4

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08534 (2/2) Redoxin
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
precursor_jaccard_groups_2133 37.32 +- 36.01 10 0 0 0 0.10 +- 0.06 10 3

PF13480 (10/10) Acetyltransferase (GNAT) domain
PF01522 (10/10) Polysaccharide deacetylase
PF00535 (10/10) Glycosyl transferase family 2
precursor_jaccard_groups_32433 166.12 +- 93.88 2 0 0 0 0.02 +- 0.02 2 4

TIGR03666 (2/2) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07335 (2/2) Fungal chitosanase of glycosyl hydrolase group 75
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_33816 31.41 +- 2.73 2 0 0 0 0.22 +- 0.34 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13620 (2/2) Carboxypeptidase regulatory-like domain
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF04264 (2/2) YceI-like domain
PF01047 (2/2) MarR family
precursor_jaccard_groups_14005 208.27 +- 86.13 4 0 0 0 0.03 +- 0.06 4 3

PF09265 (4/4) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF01565 (4/4) FAD binding domain
PF00294 (4/4) pfkB family carbohydrate kinase
precursor_jaccard_groups_2686 158.95 +- 206.43 8 0 5 0 0.07 +- 0.11 8 6

PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (8/8) BFD-like [2Fe-2S] binding domain
PF02782 (8/8) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (8/8) FAD dependent oxidoreductase
PF00370 (8/8) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (5/8) NUDIX domain
precursor_jaccard_groups_9456 38.24 +- 1.45 2 0 1 0 0.15 +- 0.12 2 10

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF12138 (2/2) Spherulation-specific family 4
PF11997 (2/2) Domain of unknown function (DUF3492)
PF03537 (2/2) Glycoside-hydrolase family GH114
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00534 (2/2) Glycosyl transferases group 1
PF00483 (2/2) Nucleotidyl transferase
PF07690 (1/2) Major Facilitator Superfamily
PF01494 (1/2) FAD binding domain
PF00383 (1/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_24503 73.19 +- 11.76 2 0 2 0 0.08 +- 0.08 2 14

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13560 (2/2) Helix-turn-helix domain
PF13478 (2/2) XdhC Rossmann domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00756 (2/2) Putative esterase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_11516 331.75 +- 90.93 4 0 0 0 0.04 +- 0.04 4 14

TIGR02138 (4/4) phosphate ABC transporter, permease protein PstC
TIGR01076 (4/4) sortase
TIGR00974 (4/4) phosphate ABC transporter, permease protein PstA
TIGR00972 (4/4) phosphate ABC transporter, ATP-binding protein
PF18431 (4/4) Bacterial CdiA-CT RNAse A domain
PF16640 (4/4) Bacterial Ig-like domain (group 3)
PF12849 (4/4) PBP superfamily domain
PF06013 (4/4) Proteins of 100 residues with WXG
PF05908 (4/4) Poly-gamma-glutamate hydrolase
PF04203 (4/4) Sortase domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00005 (4/4) ABC transporter
PF18593 (3/4) CdiI immunity protein
PF00041 (3/4) Fibronectin type III domain
precursor_jaccard_groups_11513 13.58 +- 0.00 2 0 0 0 0.15 +- 0.15 2 3

PF03621 (2/2) MbtH-like protein
PF01435 (2/2) Peptidase family M48
PF01186 (2/2) Lysyl oxidase
precursor_jaccard_groups_25122 33.44 +- 6.56 2 0 0 0 0.12 +- 0.09 2 9

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00689 (2/2) sugar-phosphate isomerase, RpiB/LacA/LacB family
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_18235 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
precursor_jaccard_groups_36334 118.09 +- 27.25 2 0 0 0 0.12 +- 0.15 2 15

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_32615 176.31 +- 11.52 2 0 2 0 0.11 +- 0.24 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF14016 (2/2) Protein of unknown function (DUF4232)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13460 (2/2) NAD(P)H-binding
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF04264 (2/2) YceI-like domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03321 (2/2) GH3 auxin-responsive promoter
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF01695 (2/2) IstB-like ATP binding protein
PF00665 (2/2) Integrase core domain
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF02910 (1/2) Fumarate reductase flavoprotein C-term
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_15609 158.00 +- 72.96 3 0 0 0 0.02 +- 0.01 3 2

PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_9072 165.12 +- 57.92 5 0 0 0 0.02 +- 0.01 5 2

PF00583 (5/5) Acetyltransferase (GNAT) family
PF00155 (5/5) Aminotransferase class I and II
precursor_jaccard_groups_18127 178.62 +- 0.00 2 0 2 2 0.02 +- 0.00 2 3

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
precursor_jaccard_groups_8850 198.26 +- 30.71 4 0 0 0 0.02 +- 0.01 4 6

PF12740 (4/4) Chlorophyllase enzyme
PF08223 (4/4) PaaX-like protein C-terminal domain
PF07848 (4/4) PaaX-like protein
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF00069 (4/4) Protein kinase domain
PF17765 (2/4) MmyB-like transcription regulator ligand binding domain
precursor_jaccard_groups_43955 618.82 +- 525.18 2 0 2 0 0.06 +- 0.20 2 21

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01553 (2/2) Acyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00975 (2/2) Thioesterase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01575 (1/2) MaoC like domain
precursor_jaccard_groups_43954 196.88 +- 46.88 2 0 2 0 0.02 +- 0.01 2 10

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF11639 (2/2) REDY-like protein HapK
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01839 (2/2) FG-GAP repeat
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_901 60.37 +- 28.17 28 0 0 0 0.19 +- 0.13 28 7

PF13416 (28/28) Bacterial extracellular solute-binding protein
PF08533 (28/28) Beta-galactosidase C-terminal domain
PF02449 (28/28) Beta-galactosidase
PF00528 (28/28) Binding-protein-dependent transport system inner membrane component
PF08532 (27/28) Beta-galactosidase trimerisation domain
PF01670 (27/28) Glycosyl hydrolase family 12
PF14498 (23/28) Glycosyl hydrolase family 65, N-terminal domain
precursor_jaccard_groups_36909 664.57 +- 367.43 2 0 2 0 0.02 +- 0.02 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_9581 69.35 +- 20.90 5 0 5 0 0.06 +- 0.05 5 10

TIGR01613 (5/5) phage/plasmid primase, P4 family, C-terminal domain
TIGR00778 (5/5) alkylhydroperoxidase AhpD family core domain
PF13454 (5/5) FAD-NAD(P)-binding
PF09250 (5/5) Bifunctional DNA primase/polymerase, N-terminal
PF08706 (5/5) D5 N terminal like
PF03288 (5/5) Poxvirus D5 protein-like
PF02896 (5/5) PEP-utilising enzyme, TIM barrel domain
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00391 (5/5) PEP-utilising enzyme, mobile domain
PF01717 (4/5) Cobalamin-independent synthase, Catalytic domain
precursor_jaccard_groups_23345 87.54 +- 49.34 3 0 0 0 0.03 +- 0.04 3 3

PF13328 (3/3) HD domain
PF08962 (3/3) Domain of unknown function (DUF1876)
PF00069 (3/3) Protein kinase domain
precursor_jaccard_groups_19624 63.39 +- 17.86 2 0 0 0 0.04 +- 0.02 2 5

PF13404 (2/2) AsnC-type helix-turn-helix domain
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_jaccard_groups_18832 113.24 +- 45.10 3 0 0 0 0.03 +- 0.03 3 3

PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF00106 (3/3) short chain dehydrogenase
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_18121 20.71 +- 3.28 3 0 3 0 0.15 +- 0.27 3 9

PF18029 (3/3) Glyoxalase-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (3/3) Alpha mannosidase middle domain
PF03644 (3/3) Glycosyl hydrolase family 85
PF01074 (3/3) Glycosyl hydrolases family 38 N-terminal domain
PF00754 (3/3) F5/8 type C domain
PF00720 (3/3) Subtilisin inhibitor-like
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_15519 282.67 +- 79.50 3 0 2 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01180 (3/3) Dihydroorotate dehydrogenase
precursor_jaccard_groups_32762 40.06 +- 1.82 2 0 1 0 0.13 +- 0.06 2 14

TIGR01375 (2/2) sarcosine oxidase, gamma subunit family
TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_40887 195.60 +- 94.65 2 0 2 0 0.02 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_14351 570.07 +- 368.19 4 0 4 0 0.05 +- 0.03 4 25

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_4549 216.83 +- 179.94 5 0 0 0 0.07 +- 0.10 5 6

PF12696 (5/5) TraM recognition site of TraD and TraG
PF03771 (5/5) Domain of unknown function (DUF317)
PF00877 (5/5) NlpC/P60 family
PF00535 (5/5) Glycosyl transferase family 2
PF07690 (4/5) Major Facilitator Superfamily
PF13535 (3/5) ATP-grasp domain
precursor_jaccard_groups_19298 80.99 +- 11.14 2 0 2 0 0.11 +- 0.28 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_6456 30.63 +- 8.40 6 0 0 0 0.11 +- 0.16 6 5

PF16157 (6/6) Domain of unknown function (DUF4865)
PF13977 (6/6) BetI-type transcriptional repressor, C-terminal
PF07883 (6/6) Cupin domain
PF02126 (6/6) Phosphotriesterase family
PF00440 (6/6) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_43219 130.78 +- 92.08 2 0 0 0 0.05 +- 0.09 2 3

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01596 (2/2) O-methyltransferase
PF01474 (2/2) Class-II DAHP synthetase family
precursor_jaccard_groups_2451 150.54 +- 185.97 15 0 0 0 0.04 +- 0.05 15 4

PF04199 (15/15) Putative cyclase
PF02776 (15/15) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF00205 (15/15) Thiamine pyrophosphate enzyme, central domain
PF02775 (13/15) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
precursor_jaccard_groups_8215 155.27 +- 14.26 3 0 0 0 0.07 +- 0.16 3 10

TIGR00262 (3/3) tryptophan synthase, alpha subunit
PF12696 (3/3) TraM recognition site of TraD and TraG
PF07728 (3/3) AAA domain (dynein-related subfamily)
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF00772 (3/3) DnaB-like helicase N terminal domain
PF00535 (3/3) Glycosyl transferase family 2
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00290 (3/3) Tryptophan synthase alpha chain
PF00145 (3/3) C-5 cytosine-specific DNA methylase
precursor_jaccard_groups_9294 62.04 +- 7.30 2 0 0 0 0.07 +- 0.07 2 4

PF13411 (2/2) MerR HTH family regulatory protein
PF01425 (2/2) Amidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_13641 180.76 +- 121.38 4 0 4 0 0.08 +- 0.16 4 15

TIGR03150 (4/4) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR00517 (4/4) acyl carrier protein
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00171 (4/4) Aldehyde dehydrogenase family
PF00155 (4/4) Aminotransferase class I and II
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_836 298.22 +- 278.02 12 1 11 12 0.05 +- 0.13 11 8

TIGR03891 (12/12) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (12/12) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (12/12) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (12/12) Lantibiotic biosynthesis dehydratase C-term
PF04738 (12/12) Lantibiotic dehydratase, N terminus
PF02624 (12/12) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/12) Nitroreductase family
TIGR03605 (7/12) SagB-type dehydrogenase domain
precursor_jaccard_groups_9292 658.02 +- 501.26 5 0 5 0 0.05 +- 0.17 5 8

TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08242 (5/5) Methyltransferase domain
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
precursor_jaccard_groups_838 39.20 +- 5.15 7 0 0 0 0.19 +- 0.25 7 7

TIGR04215 (7/7) choice-of-anchor A domain
TIGR02276 (7/7) 40-residue YVTN family beta-propeller repeat
PF17964 (7/7) Bacterial Ig domain
PF17802 (7/7) Prealbumin-like fold domain
PF13499 (7/7) EF-hand domain pair
PF03734 (7/7) L,D-transpeptidase catalytic domain
PF01522 (7/7) Polysaccharide deacetylase
precursor_jaccard_groups_1258 12.19 +- 4.03 20 0 0 0 0.18 +- 0.06 20 5

TIGR03802 (20/20) aspartate-alanine antiporter
TIGR03801 (20/20) aspartate 4-decarboxylase
PF06826 (20/20) Predicted Permease Membrane Region
PF02080 (20/20) TrkA-C domain
PF00155 (20/20) Aminotransferase class I and II
precursor_jaccard_groups_32872 18.63 +- 2.64 2 0 0 0 0.16 +- 0.10 2 6

PF13247 (2/2) 4Fe-4S dicluster domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_34827 96.37 +- 5.37 2 0 0 0 0.03 +- 0.04 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_32290 304.91 +- 46.91 2 0 0 0 0.02 +- 0.02 2 13

TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13466 (2/2) STAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03793 (2/2) PASTA domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (2/2) STAS domain
PF00989 (2/2) PAS fold
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_29858 839.62 +- 720.38 2 0 2 0 0.06 +- 0.20 2 11

TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (2/2) dihydroorotate dehydrogenase family protein
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF09084 (2/2) NMT1/THI5 like
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF00589 (1/2) Phage integrase family
precursor_jaccard_groups_37061 134.23 +- 12.02 2 0 2 0 0.03 +- 0.03 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03109 (2/2) ABC1 family
PF00487 (2/2) Fatty acid desaturase
precursor_jaccard_groups_579 86.17 +- 58.59 4 0 0 0 0.08 +- 0.13 4 6

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/4) Sigma-70, region 4
PF06108 (4/4) Protein of unknown function (DUF952)
PF04542 (4/4) Sigma-70 region 2
PF03795 (4/4) YCII-related domain
PF01872 (3/4) RibD C-terminal domain
precursor_jaccard_groups_37068 228.68 +- 78.77 2 0 1 0 0.05 +- 0.08 2 9

PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13377 (2/2) Periplasmic binding protein-like domain
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_21197 258.00 +- 0.00 3 0 0 0 0.01 +- 0.00 3 3

PF12833 (3/3) Helix-turn-helix domain
PF02311 (3/3) AraC-like ligand binding domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_9855 387.82 +- 122.11 5 0 0 0 0.01 +- 0.01 5 5

PF16859 (5/5) Tetracyclin repressor-like, C-terminal domain
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF01243 (5/5) Pyridoxamine 5'-phosphate oxidase
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_29934 449.26 +- 376.34 2 0 0 0 0.05 +- 0.19 2 7

PF13462 (2/2) Thioredoxin
PF11292 (2/2) Protein of unknown function (DUF3093)
PF09678 (2/2) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF00484 (2/2) Carbonic anhydrase
PF07987 (1/2) Domain of unkown function (DUF1775)
precursor_jaccard_groups_7947 30.29 +- 4.94 3 0 0 0 0.10 +- 0.12 3 5

PF14342 (3/3) Domain of unknown function (DUF4396)
PF07690 (3/3) Major Facilitator Superfamily
PF03860 (3/3) Domain of Unknown Function (DUF326)
PF03713 (3/3) Domain of unknown function (DUF305)
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_34255 432.28 +- 0.00 2 0 2 0 0.05 +- 0.12 2 20

TIGR01733 (2/2) amino acid adenylation domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF05050 (2/2) Methyltransferase FkbM domain
PF03621 (2/2) MbtH-like protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_12176 142.15 +- 116.47 4 0 0 0 0.07 +- 0.13 4 7

PF16353 (4/4) Domain of unknown function(DUF4981)
PF13385 (4/4) Concanavalin A-like lectin/glucanases superfamily
PF09995 (4/4) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/4) Glycosyl hydrolases family 2
precursor_jaccard_groups_22760 24.37 +- 3.16 3 0 0 0 0.20 +- 0.11 3 3

TIGR00500 (3/3) methionine aminopeptidase, type I
PF02031 (3/3) Streptomyces extracellular neutral proteinase (M7) family
PF00557 (3/3) Metallopeptidase family M24
precursor_jaccard_groups_12541 63.39 +- 13.39 2 0 2 0 0.12 +- 0.21 2 13

TIGR01733 (2/2) amino acid adenylation domain
TIGR01167 (2/2) LPXTG cell wall anchor domain
PF14012 (2/2) Protein of unknown function (DUF4229)
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00375 (2/2) Sodium:dicarboxylate symporter family
PF17932 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_34551 126.16 +- 12.76 2 0 2 0 0.17 +- 0.31 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF05534 (2/2) HicB family
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_19058 242.64 +- 117.60 3 0 3 0 0.04 +- 0.05 3 15

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF03060 (3/3) Nitronate monooxygenase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00698 (3/3) Acyl transferase domain
PF00664 (3/3) ABC transporter transmembrane region
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
TIGR01426 (2/3) glycosyltransferase, MGT family
PF05270 (2/3) Alpha-L-arabinofuranosidase B (ABFB) domain
precursor_jaccard_groups_10204 176.96 +- 65.89 5 0 5 5 0.08 +- 0.14 5 12

TIGR01187 (5/5) polyamine ABC transporter, ATP-binding protein
PF13575 (5/5) Domain of unknown function (DUF4135)
PF13416 (5/5) Bacterial extracellular solute-binding protein
PF08402 (5/5) TOBE domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF01593 (5/5) Flavin containing amine oxidoreductase
PF00848 (5/5) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00171 (5/5) Aldehyde dehydrogenase family
PF00005 (5/5) ABC transporter
TIGR03897 (3/5) type 2 lantibiotic biosynthesis protein LanM
precursor_jaccard_groups_12770 104.16 +- 31.25 4 0 0 0 0.03 +- 0.03 4 8

PF12697 (4/4) Alpha/beta hydrolase family
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF00667 (4/4) FAD binding domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00258 (4/4) Flavodoxin
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00107 (4/4) Zinc-binding dehydrogenase
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_41637 509.69 +- 54.69 2 0 2 0 0.01 +- 0.00 2 9

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
precursor_jaccard_groups_36193 48.84 +- 11.60 2 0 2 0 0.23 +- 0.31 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01167 (2/2) LPXTG cell wall anchor domain
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14012 (2/2) Protein of unknown function (DUF4229)
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00375 (2/2) Sodium:dicarboxylate symporter family
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF01756 (1/2) Acyl-CoA oxidase
precursor_jaccard_groups_12776 43.22 +- 4.86 2 0 0 0 0.21 +- 0.14 2 9

PF18011 (2/2) C-terminal domain found in long catalases
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF06628 (2/2) Catalase-related immune-responsive
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00199 (2/2) Catalase
PF13185 (1/2) GAF domain
PF03861 (1/2) ANTAR domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_14911 157.91 +- 24.09 2 0 0 0 0.03 +- 0.03 2 12

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14016 (2/2) Protein of unknown function (DUF4232)
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00775 (2/2) Dioxygenase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_42845 1241.09 +- 448.91 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6573 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II
precursor_jaccard_groups_5160 174.14 +- 108.66 6 0 5 0 0.02 +- 0.02 6 4

PF10067 (6/6) Predicted membrane protein (DUF2306)
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF00107 (6/6) Zinc-binding dehydrogenase
PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_38287 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6
precursor_jaccard_groups_12512 140.58 +- 23.65 4 0 0 4 0.02 +- 0.01 4 4

PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF04339 (4/4) Peptidogalycan biosysnthesis/recognition
PF04055 (4/4) Radical SAM superfamily
PF00303 (4/4) Thymidylate synthase
precursor_jaccard_groups_16073 41.84 +- 36.08 3 0 0 0 0.09 +- 0.07 3 3

PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF02195 (2/3) ParB-like nuclease domain
precursor_jaccard_groups_45355 164.67 +- 95.33 2 0 2 0 0.02 +- 0.03 2 3

PF02350 (2/2) UDP-N-acetylglucosamine 2-epimerase
PF00069 (2/2) Protein kinase domain
TIGR00236 (1/2) UDP-N-acetylglucosamine 2-epimerase
precursor_jaccard_groups_38215 14.74 +- 0.08 2 0 0 0 0.14 +- 0.13 2 5

PF12950 (2/2) TaqI-like C-terminal specificity domain
PF07669 (2/2) Eco57I restriction-modification methylase
PF04555 (2/2) Restriction endonuclease XhoI
PF02441 (2/2) Flavoprotein
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_4166 168.44 +- 128.63 10 0 2 0 0.15 +- 0.08 10 18

PF14310 (10/10) Fibronectin type III-like domain
PF13377 (10/10) Periplasmic binding protein-like domain
PF09084 (10/10) NMT1/THI5 like
PF01915 (10/10) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF00933 (10/10) Glycosyl hydrolase family 3 N terminal domain
PF00753 (10/10) Metallo-beta-lactamase superfamily
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00356 (10/10) Bacterial regulatory proteins, lacI family
PF00150 (10/10) Cellulase (glycosyl hydrolase family 5)
PF00135 (10/10) Carboxylesterase family
PF00005 (10/10) ABC transporter
PF16197 (7/10) Ketoacyl-synthetase C-terminal extension
PF02801 (7/10) Beta-ketoacyl synthase, C-terminal domain
PF01370 (7/10) NAD dependent epimerase/dehydratase family
PF00155 (7/10) Aminotransferase class I and II
PF00109 (7/10) Beta-ketoacyl synthase, N-terminal domain
PF00067 (7/10) Cytochrome P450
precursor_jaccard_groups_13820 34.09 +- 15.72 3 0 0 0 0.17 +- 0.24 3 7

PF00082 (3/3) Subtilase family
PF00005 (3/3) ABC transporter
PF17964 (2/3) Bacterial Ig domain
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF03734 (2/3) L,D-transpeptidase catalytic domain
PF02687 (2/3) FtsX-like permease family
PF01152 (2/3) Bacterial-like globin
precursor_jaccard_groups_16851 193.83 +- 19.72 3 0 1 0 0.05 +- 0.03 3 5

PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_16852 136.50 +- 19.50 2 0 0 0 0.03 +- 0.01 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF09339 (2/2) IclR helix-turn-helix domain
PF02525 (2/2) Flavodoxin-like fold
PF01614 (2/2) Bacterial transcriptional regulator
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF01494 (1/2) FAD binding domain
precursor_jaccard_groups_30868 328.50 +- 58.50 2 0 0 0 0.01 +- 0.00 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
precursor_jaccard_groups_22007 18.80 +- 4.95 3 0 0 0 0.11 +- 0.12 3 5

PF13489 (3/3) Methyltransferase domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
PF00204 (3/3) DNA gyrase B
precursor_jaccard_groups_38441 147.59 +- 112.41 2 0 0 0 0.03 +- 0.05 2 2

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
precursor_jaccard_groups_4767 86.49 +- 106.63 9 0 0 0 0.14 +- 0.30 9 4

PF07504 (9/9) Fungalysin/Thermolysin Propeptide Motif
PF03713 (9/9) Domain of unknown function (DUF305)
PF02868 (9/9) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (9/9) Thermolysin metallopeptidase, catalytic domain
precursor_jaccard_groups_16980 10.84 +- 1.24 3 0 0 0 0.19 +- 0.10 3 4

PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF00672 (3/3) HAMP domain
precursor_jaccard_groups_32991 55.24 +- 28.63 2 0 0 0 0.12 +- 0.21 2 11

PF09861 (2/2) Lactate racemase N-terminal domain
PF07729 (2/2) FCD domain
PF04909 (2/2) Amidohydrolase
PF01969 (2/2) Protein of unknown function DUF111
PF00731 (2/2) AIR carboxylase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
TIGR00299 (1/2) TIGR00299 family protein
TIGR00268 (1/2) TIGR00268 family protein
PF02540 (1/2) NAD synthase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
precursor_jaccard_groups_16211 232.51 +- 39.34 3 0 0 0 0.05 +- 0.09 3 11

TIGR00326 (3/3) riboflavin biosynthesis protein RibD
PF12894 (3/3) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (3/3) Major Facilitator Superfamily
PF07676 (3/3) WD40-like Beta Propeller Repeat
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (3/3) RibD C-terminal domain
PF00925 (3/3) GTP cyclohydrolase II
PF00400 (3/3) WD domain, G-beta repeat
PF00383 (3/3) Cytidine and deoxycytidylate deaminase zinc-binding region
TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13641 (2/3) Glycosyltransferase like family 2
precursor_jaccard_groups_585 20.88 +- 5.69 4 0 0 0 0.20 +- 0.28 4 10

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07690 (4/4) Major Facilitator Superfamily
PF04138 (4/4) GtrA-like protein
PF03777 (4/4) ChpA-C
PF02909 (4/4) Tetracyclin repressor-like, C-terminal domain
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (4/4) HAMP domain
PF00535 (4/4) Glycosyl transferase family 2
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_584 174.56 +- 122.08 24 0 24 24 0.05 +- 0.03 24 5

TIGR04451 (24/24) lantipeptide, SCO0268 family
TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (24/24) Lantibiotic biosynthesis dehydratase C-term
PF05147 (24/24) Lanthionine synthetase C-like protein
PF04738 (24/24) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_589 49.00 +- 0.14 2 0 0 0 0.14 +- 0.32 2 6

PF17964 (2/2) Bacterial Ig domain
PF13462 (2/2) Thioredoxin
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02600 (2/2) Disulfide bond formation protein DsbB
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_21585 177.11 +- 82.89 2 0 2 0 0.09 +- 0.13 2 13

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_25249 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_11346 26.03 +- 8.37 2 0 0 0 0.23 +- 0.28 2 11

TIGR00045 (2/2) glycerate kinase
PF07690 (2/2) Major Facilitator Superfamily
PF02595 (2/2) Glycerate kinase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (2/2) Sodium:sulfate symporter transmembrane region
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00144 (2/2) Beta-lactamase
PF00072 (2/2) Response regulator receiver domain
PF12867 (1/2) DinB superfamily
precursor_jaccard_groups_456 9.92 +- 0.00 2 0 0 0 0.20 +- 0.22 2 3

PF13328 (2/2) HD domain
PF01909 (2/2) Nucleotidyltransferase domain
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
precursor_jaccard_groups_45289 17.79 +- 0.91 2 0 0 0 0.23 +- 0.17 2 10

TIGR01660 (2/2) nitrate reductase, beta subunit
TIGR01580 (2/2) nitrate reductase, alpha subunit
TIGR00684 (2/2) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (2/2) respiratory nitrate reductase, gamma subunit
PF14711 (2/2) Respiratory nitrate reductase beta C-terminal
PF13247 (2/2) 4Fe-4S dicluster domain
PF02665 (2/2) Nitrate reductase gamma subunit
PF02613 (2/2) Nitrate reductase delta subunit
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_26625 17.20 +- 4.91 2 0 2 0 0.12 +- 0.06 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_22905 1146.00 +- 338.46 3 0 0 0 0.01 +- 0.01 3 11

TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF14518 (3/3) Iron-containing redox enzyme
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00069 (3/3) Protein kinase domain
precursor_jaccard_groups_5794 153.91 +- 63.52 6 0 6 0 0.15 +- 0.27 6 21

PF13578 (6/6) Methyltransferase domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF10604 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF08028 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (6/6) Major Facilitator Superfamily
PF04673 (6/6) Polyketide synthesis cyclase
PF03992 (6/6) Antibiotic biosynthesis monooxygenase
PF03358 (6/6) NADPH-dependent FMN reductase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF01494 (6/6) FAD binding domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00106 (6/6) short chain dehydrogenase
PF00072 (6/6) Response regulator receiver domain
PF01648 (5/6) 4'-phosphopantetheinyl transferase superfamily
TIGR00128 (4/6) malonyl CoA-acyl carrier protein transacylase
PF13822 (4/6) Acyl-CoA carboxylase epsilon subunit
PF01039 (4/6) Carboxyl transferase domain
PF00698 (4/6) Acyl transferase domain
precursor_jaccard_groups_29022 449.42 +- 324.58 2 0 0 0 0.03 +- 0.09 2 10

PF13545 (2/2) Crp-like helix-turn-helix domain
PF13191 (2/2) AAA ATPase domain
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03176 (2/2) MMPL family
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00899 (2/2) ThiF family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_5825 47.05 +- 11.67 3 0 0 0 0.20 +- 0.37 3 12

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (3/3) YD repeat (two copies)
TIGR00613 (3/3) DNA repair protein RecO
TIGR00055 (3/3) di-trans,poly-cis-decaprenylcistransferase
PF13560 (3/3) Helix-turn-helix domain
PF11967 (3/3) Recombination protein O N terminal
PF05593 (3/3) RHS Repeat
PF04149 (3/3) Domain of unknown function (DUF397)
PF02565 (3/3) Recombination protein O C terminal
PF01255 (3/3) Putative undecaprenyl diphosphate synthase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_38055 37.64 +- 1.30 2 0 0 0 0.17 +- 0.26 2 6

TIGR01426 (2/2) glycosyltransferase, MGT family
PF00535 (2/2) Glycosyl transferase family 2
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00082 (2/2) Subtilase family
PF01636 (1/2) Phosphotransferase enzyme family
PF00089 (1/2) Trypsin
precursor_jaccard_groups_38050 40.98 +- 4.64 2 0 1 0 0.10 +- 0.08 2 8

TIGR01234 (2/2) ribulokinase
PF13377 (2/2) Periplasmic binding protein-like domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_21054 324.25 +- 46.50 3 0 3 0 0.01 +- 0.00 3 7

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_13135 91.26 +- 29.72 3 0 0 0 0.02 +- 0.02 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
precursor_jaccard_groups_13130 111.70 +- 65.10 4 0 4 0 0.05 +- 0.10 4 8

TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13521 (4/4) AAA domain
PF12680 (4/4) SnoaL-like domain
PF11468 (4/4) Aromatic prenyltransferase Orf2
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05655 (4/4) Pseudomonas avirulence D protein (AvrD)
PF03358 (4/4) NADPH-dependent FMN reductase
precursor_jaccard_groups_30732 144.48 +- 113.52 2 0 0 0 0.04 +- 0.09 2 4

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF05977 (1/2) Transmembrane secretion effector
precursor_jaccard_groups_20058 18.15 +- 3.82 3 0 0 0 0.18 +- 0.33 3 7

PF17996 (3/3) Carbohydrate esterase 2 N-terminal
PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01012 (3/3) Electron transfer flavoprotein domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_29203 41.90 +- 13.50 2 0 2 2 0.15 +- 0.11 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (2/2) formate acetyltransferase
PF13247 (2/2) 4Fe-4S dicluster domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01228 (2/2) Glycine radical
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
TIGR00886 (1/2) nitrite transporter
PF07690 (1/2) Major Facilitator Superfamily
PF00501 (1/2) AMP-binding enzyme
precursor_jaccard_groups_29200 403.00 +- 247.00 2 0 0 0 0.02 +- 0.02 2 8

PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF01451 (1/2) Low molecular weight phosphotyrosine protein phosphatase
precursor_jaccard_groups_20053 189.74 +- 14.16 2 0 0 0 0.07 +- 0.06 2 7

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_2248 52.13 +- 5.65 7 0 0 0 0.21 +- 0.38 7 6

PF12840 (7/7) Helix-turn-helix domain
PF05175 (7/7) Methyltransferase small domain
PF01061 (7/7) ABC-2 type transporter
PF00005 (7/7) ABC transporter
TIGR00041 (6/7) dTMP kinase
PF02223 (6/7) Thymidylate kinase
precursor_jaccard_groups_24056 2858.53 +- 2313.20 2 0 2 0 0.03 +- 0.15 2 27

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13579 (2/2) Glycosyl transferase 4-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04909 (2/2) Amidohydrolase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02449 (2/2) Beta-galactosidase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01180 (2/2) Dihydroorotate dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
precursor_jaccard_groups_8704 331.31 +- 98.19 4 0 4 0 0.01 +- 0.01 4 6

PF13459 (4/4) 4Fe-4S single cluster domain
PF10589 (4/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (4/4) TAP-like protein
PF03640 (4/4) Secreted repeat of unknown function
PF01512 (4/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (4/4) alpha/beta hydrolase fold
precursor_jaccard_groups_28463 24.72 +- 1.08 2 0 0 0 0.08 +- 0.08 2 4

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
precursor_jaccard_groups_14736 136.83 +- 87.53 3 0 2 0 0.02 +- 0.01 3 2

PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF04616 (3/3) Glycosyl hydrolases family 43
precursor_jaccard_groups_28467 304.17 +- 54.17 2 0 0 0 0.03 +- 0.04 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_40418 485.13 +- 88.21 2 0 2 2 0.01 +- 0.01 2 11

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF13537 (2/2) Glutamine amidotransferase domain
PF07883 (2/2) Cupin domain
PF04303 (2/2) PrpF protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01979 (2/2) Amidohydrolase family
PF01361 (2/2) Tautomerase enzyme
PF00733 (2/2) Asparagine synthase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_20612 239.74 +- 77.74 3 0 2 0 0.04 +- 0.02 3 3

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF07944 (3/3) Beta-L-arabinofuranosidase, GH127
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_5959 151.58 +- 28.82 7 0 2 0 0.03 +- 0.02 7 4

PF13377 (7/7) Periplasmic binding protein-like domain
PF05199 (7/7) GMC oxidoreductase
PF00732 (7/7) GMC oxidoreductase
PF00356 (7/7) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_44401 53.92 +- 18.08 2 0 0 0 0.11 +- 0.05 2 9

TIGR02133 (2/2) ribose 5-phosphate isomerase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00121 (2/2) Triosephosphate isomerase
precursor_jaccard_groups_15989 55.87 +- 1.39 3 0 0 0 0.18 +- 0.13 3 10

PF13646 (3/3) HEAT repeats
PF12838 (3/3) 4Fe-4S dicluster domain
PF09084 (3/3) NMT1/THI5 like
PF07702 (3/3) UTRA domain
PF02910 (3/3) Fumarate reductase flavoprotein C-term
PF01797 (3/3) Transposase IS200 like
PF00890 (3/3) FAD binding domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_24990 139.98 +- 39.33 2 0 0 0 0.04 +- 0.04 2 6

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_14096 651.38 +- 451.61 3 0 0 0 0.02 +- 0.01 3 6

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF00581 (3/3) Rhodanese-like domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_124 167.81 +- 180.77 15 0 0 0 0.09 +- 0.21 15 6

PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF07690 (14/15) Major Facilitator Superfamily
PF01551 (13/15) Peptidase family M23
PF00291 (12/15) Pyridoxal-phosphate dependent enzyme
PF07739 (11/15) TipAS antibiotic-recognition domain
PF13411 (10/15) MerR HTH family regulatory protein
precursor_jaccard_groups_126 175.25 +- 126.12 48 0 0 0 0.04 +- 0.06 48 2

PF06737 (48/48) Transglycosylase-like domain
PF01476 (48/48) LysM domain
precursor_jaccard_groups_6215 314.19 +- 225.10 7 0 1 0 0.03 +- 0.08 7 8

PF13424 (7/7) Tetratricopeptide repeat
PF07690 (7/7) Major Facilitator Superfamily
PF03781 (7/7) Sulfatase-modifying factor enzyme 1
PF03704 (7/7) Bacterial transcriptional activator domain
PF03358 (7/7) NADPH-dependent FMN reductase
PF00931 (7/7) NB-ARC domain
PF00925 (7/7) GTP cyclohydrolase II
PF00400 (7/7) WD domain, G-beta repeat
precursor_jaccard_groups_11860 114.31 +- 18.14 2 0 0 0 0.08 +- 0.04 2 5

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_34295 453.84 +- 326.16 2 0 0 0 0.03 +- 0.10 2 15

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF17866 (2/2) AAA lid domain
PF13229 (2/2) Right handed beta helix region
PF13191 (2/2) AAA ATPase domain
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF01580 (2/2) FtsK/SpoIIIE family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_24752 1683.00 +- 123.00 2 0 0 0 0.01 +- 0.00 2 3

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
PF02515 (1/2) CoA-transferase family III
precursor_jaccard_groups_15191 20.32 +- 2.96 3 0 1 0 0.15 +- 0.06 3 4

TIGR00791 (3/3) transporter, gluconate:H+ symporter (GntP) family
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02447 (3/3) GntP family permease
precursor_jaccard_groups_45623 16.08 +- 2.16 2 0 0 0 0.22 +- 0.37 2 6

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01694 (2/2) methylthioadenosine phosphorylase
PF09723 (2/2) Zinc ribbon domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01048 (2/2) Phosphorylase superfamily
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_29045 53.35 +- 6.08 2 0 2 2 0.08 +- 0.06 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF00704 (2/2) Glycosyl hydrolases family 18
PF00553 (2/2) Cellulose binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_28880 61.81 +- 9.42 2 0 1 0 0.15 +- 0.34 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
PF13581 (1/2) Histidine kinase-like ATPase domain
PF04952 (1/2) Succinylglutamate desuccinylase / Aspartoacylase family
precursor_jaccard_groups_3525 17.11 +- 7.52 4 0 0 0 0.16 +- 0.18 4 5

PF16697 (4/4) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (4/4) ABC-2 type transporter
PF00498 (4/4) FHA domain
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_38122 262.45 +- 4.45 2 0 0 0 0.02 +- 0.02 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF05853 (2/2) beta-keto acid cleavage enzyme
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00474 (2/2) Sodium:solute symporter family
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_4200 52.08 +- 6.11 8 0 0 0 0.19 +- 0.35 8 8

TIGR00042 (8/8) non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
PF07730 (8/8) Histidine kinase
PF01725 (8/8) Ham1 family
PF01061 (8/8) ABC-2 type transporter
PF00196 (8/8) Bacterial regulatory proteins, luxR family
PF00072 (8/8) Response regulator receiver domain
PF00005 (8/8) ABC transporter
PF02518 (7/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_3523 190.61 +- 166.56 10 0 0 10 0.05 +- 0.05 10 11

TIGR03606 (10/10) dehydrogenase, PQQ-dependent, s-GDH family
TIGR02111 (10/10) coenzyme PQQ biosynthesis protein C
TIGR02109 (10/10) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (10/10) Iron-sulfur cluster-binding domain
PF12706 (10/10) Beta-lactamase superfamily domain
PF07995 (10/10) Glucose / Sorbosone dehydrogenase
PF04055 (10/10) Radical SAM superfamily
PF03070 (10/10) TENA/THI-4/PQQC family
PF00440 (10/10) Bacterial regulatory proteins, tetR family
PF00067 (10/10) Cytochrome P450
PF13459 (8/10) 4Fe-4S single cluster domain
precursor_jaccard_groups_4970 382.43 +- 479.69 9 0 9 9 0.10 +- 0.26 9 6

PF06114 (9/9) IrrE N-terminal-like domain
PF05147 (9/9) Lanthionine synthetase C-like protein
PF02687 (9/9) FtsX-like permease family
PF00082 (9/9) Subtilase family
PF00069 (9/9) Protein kinase domain
PF00005 (9/9) ABC transporter
precursor_jaccard_groups_17039 89.22 +- 38.28 3 0 0 0 0.14 +- 0.16 3 8

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF01613 (3/3) Flavin reductase like domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00480 (3/3) ROK family
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
PF00248 (2/3) Aldo/keto reductase family
precursor_jaccard_groups_19308 4213.72 +- 3526.28 2 0 1 2 0.02 +- 0.03 2 32

TIGR01762 (2/2) chlorinating enzyme
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF14805 (2/2) Tetrahydrodipicolinate N-succinyltransferase N-terminal
PF14602 (2/2) Hexapeptide repeat of succinyl-transferase
PF13535 (2/2) ATP-grasp domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05199 (2/2) GMC oxidoreductase
PF04909 (2/2) Amidohydrolase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00733 (2/2) Asparagine synthase
PF00732 (2/2) GMC oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00155 (2/2) Aminotransferase class I and II
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF18130 (1/2) ATP-grasp N-terminal domain
PF13845 (1/2) Septum formation
PF13828 (1/2) Domain of unknown function (DUF4190)
PF13537 (1/2) Glutamine amidotransferase domain
PF13522 (1/2) Glutamine amidotransferase domain
PF05960 (1/2) Bacterial protein of unknown function (DUF885)
PF00271 (1/2) Helicase conserved C-terminal domain
PF00176 (1/2) SNF2 family N-terminal domain
PF00149 (1/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_28641 56.58 +- 29.42 2 0 0 0 0.05 +- 0.03 2 3

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
precursor_jaccard_groups_44712 3900.00 +- 780.00 2 0 2 2 0.01 +- 0.00 2 10

TIGR04267 (2/2) HEXXH motif domain
PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF13535 (2/2) ATP-grasp domain
PF07931 (2/2) Chloramphenicol phosphotransferase-like protein
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_20188 204.18 +- 77.53 3 0 0 0 0.01 +- 0.01 3 1

PF01833 (3/3) IPT/TIG domain
precursor_jaccard_groups_15214 78.71 +- 73.04 3 0 0 0 0.11 +- 0.28 3 7

PF13462 (3/3) Thioredoxin
PF11292 (3/3) Protein of unknown function (DUF3093)
PF09678 (3/3) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF07987 (3/3) Domain of unkown function (DUF1775)
PF05425 (3/3) Copper resistance protein D
PF04234 (3/3) CopC domain
PF00484 (3/3) Carbonic anhydrase
precursor_jaccard_groups_4356 202.15 +- 109.88 9 0 9 0 0.02 +- 0.01 9 7

TIGR04475 (9/9) phenylalanine aminomutase (D-beta-phenylalanine forming)
PF14534 (9/9) Domain of unknown function (DUF4440)
PF13977 (9/9) BetI-type transcriptional repressor, C-terminal
PF13459 (9/9) 4Fe-4S single cluster domain
PF00440 (9/9) Bacterial regulatory proteins, tetR family
PF00221 (9/9) Aromatic amino acid lyase
PF00067 (9/9) Cytochrome P450
precursor_jaccard_groups_25351 541.21 +- 462.12 2 0 2 0 0.08 +- 0.25 2 8

PF13732 (2/2) Domain of unknown function (DUF4162)
PF01061 (2/2) ABC-2 type transporter
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
PF12697 (1/2) Alpha/beta hydrolase family
PF01134 (1/2) Glucose inhibited division protein A
PF00561 (1/2) alpha/beta hydrolase fold
precursor_jaccard_groups_31420 129.50 +- 0.50 2 0 2 0 0.02 +- 0.01 2 5

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_31421 9.22 +- 0.48 2 0 2 0 0.22 +- 0.20 2 5

PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF13581 (1/2) Histidine kinase-like ATPase domain
precursor_jaccard_groups_34906 12.71 +- 0.98 2 0 0 0 0.16 +- 0.01 2 2

PF08241 (2/2) Methyltransferase domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_30309 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_44668 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
precursor_jaccard_groups_12302 63.94 +- 30.61 2 0 1 0 0.05 +- 0.07 2 6

PF17829 (2/2) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (2/2) Glycosyl hydrolase family 115
PF13191 (2/2) AAA ATPase domain
PF00067 (2/2) Cytochrome P450
PF17996 (1/2) Carbohydrate esterase 2 N-terminal
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
precursor_jaccard_groups_40564 323.75 +- 1.25 2 0 0 0 0.01 +- 0.01 2 7

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07690 (2/2) Major Facilitator Superfamily
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_42708 177.75 +- 80.25 2 0 1 0 0.01 +- 0.01 2 3

PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
precursor_jaccard_groups_42700 238.98 +- 117.11 2 0 1 0 0.05 +- 0.04 2 10

PF17387 (2/2) Glycosyl hydrolase family 59 central domain
PF13407 (2/2) Periplasmic binding protein domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02057 (2/2) Glycosyl hydrolase family 59
PF00703 (2/2) Glycosyl hydrolases family 2
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00005 (2/2) ABC transporter
PF03466 (1/2) LysR substrate binding domain
precursor_jaccard_groups_33956 134.01 +- 78.72 2 0 2 2 0.06 +- 0.05 2 9

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat
precursor_jaccard_groups_19591 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_31088 463.12 +- 268.12 2 0 0 0 0.03 +- 0.02 2 7

TIGR01728 (2/2) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF09084 (2/2) NMT1/THI5 like
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_31737 206.27 +- 183.73 2 0 2 0 0.07 +- 0.20 2 6

PF18765 (2/2) Polymerase beta, Nucleotidyltransferase
PF06236 (2/2) Tyrosinase co-factor MelC1
PF00296 (2/2) Luciferase-like monooxygenase
PF00293 (2/2) NUDIX domain
PF00264 (2/2) Common central domain of tyrosinase
PF13228 (1/2) Domain of unknown function (DUF4037)
precursor_jaccard_groups_30307 237.03 +- 98.37 2 0 0 0 0.02 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_39099 56.65 +- 11.50 2 0 0 0 0.06 +- 0.04 2 7

PF04016 (2/2) Putative heavy-metal chelation
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
PF05175 (1/2) Methyltransferase small domain
precursor_jaccard_groups_21824 212.77 +- 130.96 3 0 0 0 0.08 +- 0.11 3 19

TIGR03668 (3/3) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (3/3) probable F420-dependent oxidoreductase, Rv2161c family
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13529 (3/3) Peptidase_C39 like family
PF03547 (3/3) Membrane transport protein
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
TIGR02980 (2/3) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF12697 (2/3) Alpha/beta hydrolase family
PF07729 (2/3) FCD domain
PF06684 (2/3) Amino acid synthesis
PF04545 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
PF04539 (2/3) Sigma-70 region 3
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00171 (2/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_11640 129.97 +- 51.79 4 0 0 0 0.08 +- 0.13 4 16

TIGR03026 (4/4) nucleotide sugar dehydrogenase
TIGR00696 (4/4) glycosyltransferase, WecB/TagA/CpsF family
PF14602 (4/4) Hexapeptide repeat of succinyl-transferase
PF13440 (4/4) Polysaccharide biosynthesis protein
PF03808 (4/4) Glycosyl transferase WecB/TagA/CpsF family
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02350 (4/4) UDP-N-acetylglucosamine 2-epimerase
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (4/4) Glycosyl transferase family 2
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
TIGR00236 (3/4) UDP-N-acetylglucosamine 2-epimerase
PF08240 (3/4) Alcohol dehydrogenase GroES-like domain
PF01614 (3/4) Bacterial transcriptional regulator
PF00107 (3/4) Zinc-binding dehydrogenase
PF02706 (2/4) Chain length determinant protein
precursor_jaccard_groups_7532 242.88 +- 28.52 4 0 0 0 0.01 +- 0.00 4 5

TIGR01549 (4/4) HAD hydrolase, family IA, variant 1
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00155 (4/4) Aminotransferase class I and II
precursor_jaccard_groups_19617 259.33 +- 0.94 3 0 0 0 0.01 +- 0.00 3 3

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00550 (3/3) Phosphopantetheine attachment site
precursor_jaccard_groups_5222 262.58 +- 109.46 7 0 0 0 0.01 +- 0.01 7 6

PF17137 (7/7) Domain of unknown function (DUF5110)
PF16990 (7/7) Carbohydrate binding module (family 35)
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF03595 (7/7) Voltage-dependent anion channel
PF02852 (7/7) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01055 (7/7) Glycosyl hydrolases family 31
precursor_jaccard_groups_4358 630.67 +- 254.09 3 0 0 0 0.03 +- 0.03 3 14

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF02449 (3/3) Beta-galactosidase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00135 (3/3) Carboxylesterase family
PF16499 (2/3) Alpha galactosidase A
PF14508 (2/3) Glycosyl-hydrolase 97 N-terminal
PF06964 (2/3) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/3) Glycosyl hydrolases family 43
precursor_jaccard_groups_43035 69.55 +- 8.45 2 0 0 0 0.04 +- 0.05 2 3

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF00719 (2/2) Inorganic pyrophosphatase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_543 13.69 +- 3.24 3 0 0 0 0.17 +- 0.15 3 3

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF12697 (2/3) Alpha/beta hydrolase family
precursor_jaccard_groups_2695 14.92 +- 2.40 7 0 0 0 0.21 +- 0.21 7 8

TIGR00026 (7/7) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13589 (7/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF04075 (7/7) F420H(2)-dependent quinone reductase
PF00183 (7/7) Hsp90 protein
PF13483 (6/7) Beta-lactamase superfamily domain
PF01738 (6/7) Dienelactone hydrolase family
PF00355 (6/7) Rieske [2Fe-2S] domain
PF09490 (5/7) Probable cobalt transporter subunit (CbtA)
precursor_jaccard_groups_39932 246.68 +- 140.32 2 0 2 0 0.02 +- 0.02 2 4

PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_42636 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_43728 50.95 +- 2.43 2 0 0 0 0.21 +- 0.21 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF02777 (1/2) Iron/manganese superoxide dismutases, C-terminal domain
PF00081 (1/2) Iron/manganese superoxide dismutases, alpha-hairpin domain
precursor_jaccard_groups_11587 60.11 +- 9.38 4 0 0 0 0.07 +- 0.05 4 12

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18130 (4/4) ATP-grasp N-terminal domain
PF17802 (4/4) Prealbumin-like fold domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF01555 (4/4) DNA methylase
PF01068 (4/4) ATP dependent DNA ligase domain
precursor_jaccard_groups_3742 36.71 +- 11.64 4 0 0 0 0.12 +- 0.20 4 5

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF12172 (4/4) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08445 (4/4) FR47-like protein
PF07681 (4/4) DoxX
PF01796 (4/4) DUF35 OB-fold domain, acyl-CoA-associated
precursor_jaccard_groups_30094 45.07 +- 5.68 2 0 0 0 0.10 +- 0.10 2 7

TIGR00879 (2/2) MFS transporter, sugar porter (SP) family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01910 (2/2) Thiamine-binding protein
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
PF06114 (1/2) IrrE N-terminal-like domain
precursor_jaccard_groups_6138 159.06 +- 45.79 2 0 1 0 0.06 +- 0.08 2 8

PF12696 (2/2) TraM recognition site of TraD and TraG
PF03771 (2/2) Domain of unknown function (DUF317)
PF00772 (2/2) DnaB-like helicase N terminal domain
PF00145 (2/2) C-5 cytosine-specific DNA methylase
PF11203 (1/2) Putative type VII ESX secretion system translocon, EccE
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF00877 (1/2) NlpC/P60 family
PF00535 (1/2) Glycosyl transferase family 2
precursor_jaccard_groups_28495 44.20 +- 4.17 2 0 0 0 0.07 +- 0.06 2 5

PF02945 (2/2) Recombination endonuclease VII
PF00950 (2/2) ABC 3 transport family
PF00891 (2/2) O-methyltransferase domain
PF00351 (2/2) Biopterin-dependent aromatic amino acid hydroxylase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_24716 14.31 +- 0.32 2 0 0 0 0.21 +- 0.24 2 7

TIGR01581 (2/2) NifC-like ABC-type porter
PF08544 (2/2) GHMP kinases C terminal
PF03459 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11503 106.42 +- 47.85 4 0 0 0 0.02 +- 0.01 4 2

TIGR03930 (4/4) WXG100 family type VII secretion target
PF06013 (4/4) Proteins of 100 residues with WXG
precursor_jaccard_groups_31553 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF12802 (2/2) MarR family
PF09335 (2/2) SNARE associated Golgi protein
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain
precursor_jaccard_groups_31883 387.00 +- 129.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR00654 (2/2) phenazine biosynthesis protein, PhzF family
PF02567 (2/2) Phenazine biosynthesis-like protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
precursor_jaccard_groups_31557 207.41 +- 9.31 2 0 0 0 0.09 +- 0.16 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01120 (2/2) Alpha-L-fucosidase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
PF17754 (1/2) MftR C-terminal domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF10518 (1/2) TAT (twin-arginine translocation) pathway signal sequence
PF07859 (1/2) alpha/beta hydrolase fold
PF00754 (1/2) F5/8 type C domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_31558 48.84 +- 19.96 2 0 0 0 0.05 +- 0.08 2 4

PF13581 (2/2) Histidine kinase-like ATPase domain
PF04248 (2/2) Domain of unknown function (DUF427)
PF01323 (2/2) DSBA-like thioredoxin domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_23199 201.84 +- 49.19 3 0 0 0 0.12 +- 0.20 3 23

TIGR04037 (3/3) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (3/3) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF17853 (3/3) GGDEF-like domain
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14525 (3/3) AraC-binding-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13191 (3/3) AAA ATPase domain
PF12833 (3/3) Helix-turn-helix domain
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07969 (3/3) Amidohydrolase family
PF07859 (3/3) alpha/beta hydrolase fold
PF07681 (3/3) DoxX
PF03358 (3/3) NADPH-dependent FMN reductase
PF02852 (3/3) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01184 (3/3) GPR1/FUN34/yaaH family
PF00857 (3/3) Isochorismatase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00210 (3/3) Ferritin-like domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_18596 431.52 +- 139.52 3 0 0 0 0.01 +- 0.01 3 9

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF07202 (3/3) T-complex protein 10 C-terminus
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_18227 547.42 +- 584.10 3 0 3 2 0.09 +- 0.23 3 24

TIGR03494 (3/3) salicylate synthase
TIGR02185 (3/3) putative ECF transporter S component, Trep_Strep family
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09605 (3/3) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF03704 (3/3) Bacterial transcriptional activator domain
PF02361 (3/3) Cobalt transport protein
PF00975 (3/3) Thioesterase domain
PF00931 (3/3) NB-ARC domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00425 (3/3) chorismate binding enzyme
PF00005 (3/3) ABC transporter
TIGR03696 (2/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
TIGR01443 (2/3) intein C-terminal splicing region
PF13537 (2/3) Glutamine amidotransferase domain
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat
PF00733 (2/3) Asparagine synthase
PF00664 (2/3) ABC transporter transmembrane region
precursor_jaccard_groups_33773 245.55 +- 107.80 2 0 0 0 0.04 +- 0.08 2 8

PF06722 (2/2) Protein of unknown function (DUF1205)
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF01804 (2/2) Penicillin amidase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9441 344.00 +- 121.62 3 0 0 0 0.01 +- 0.01 3 6

TIGR01356 (3/3) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01141 (3/3) histidinol-phosphate transaminase
PF01613 (3/3) Flavin reductase like domain
PF00275 (3/3) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_33776 16.13 +- 3.55 2 0 0 0 0.20 +- 0.09 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_42457 42.38 +- 0.62 2 0 0 0 0.09 +- 0.25 2 4

PF16945 (2/2) Putative lactococcus lactis phage r1t holin
PF08924 (2/2) Domain of unknown function (DUF1906)
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_5311 563.01 +- 487.86 8 0 8 0 0.10 +- 0.23 8 27

TIGR01830 (8/8) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (8/8) amino acid adenylation domain
TIGR01720 (8/8) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (8/8) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (8/8) Domain of unknown function (DUF4162)
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07977 (8/8) FabA-like domain
PF03621 (8/8) MbtH-like protein
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF01323 (8/8) DSBA-like thioredoxin domain
PF01061 (8/8) ABC-2 type transporter
PF00975 (8/8) Thioesterase domain
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF00005 (8/8) ABC transporter
PF13160 (7/8) Protein of unknown function (DUF3995)
TIGR03945 (6/8) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (6/8) 2,3-diaminopropionate biosynthesis protein SbnB
PF13279 (6/8) Thioesterase-like superfamily
PF12146 (6/8) Serine aminopeptidase, S33
PF06368 (6/8) Methylaspartate mutase E chain (MutE)
PF02423 (6/8) Ornithine cyclodeaminase/mu-crystallin family
PF02310 (6/8) B12 binding domain
PF00291 (6/8) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_14213 319.40 +- 14.24 4 0 0 0 0.01 +- 0.00 4 6

PF07690 (4/4) Major Facilitator Superfamily
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00899 (4/4) ThiF family
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_2342 10.52 +- 1.72 7 0 7 0 0.20 +- 0.30 7 7

TIGR00589 (7/7) methylated-DNA--[protein]-cysteine S-methyltransferase
PF12833 (7/7) Helix-turn-helix domain
PF09859 (7/7) Oxygenase, catalysing oxidative methylation of damaged DNA
PF06029 (7/7) AlkA N-terminal domain
PF02805 (7/7) Metal binding domain of Ada
PF01035 (7/7) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF02870 (4/7) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
precursor_jaccard_groups_18138 1278.10 +- 1285.56 3 0 1 0 0.01 +- 0.00 3 11

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (3/3) amino acid adenylation domain
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (3/3) Luciferase-like monooxygenase
PF00720 (2/3) Subtilisin inhibitor-like
PF00144 (2/3) Beta-lactamase
precursor_jaccard_groups_36855 141.85 +- 82.86 2 0 2 0 0.10 +- 0.09 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00664 (2/2) ABC transporter transmembrane region
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6040 400.93 +- 119.98 7 0 7 7 0.01 +- 0.01 7 3

PF13471 (7/7) Transglutaminase-like superfamily
PF00733 (7/7) Asparagine synthase
PF00005 (6/7) ABC transporter
precursor_jaccard_groups_2344 17.36 +- 3.03 2 0 0 0 0.17 +- 0.21 2 9

PF07382 (2/2) Histone H1-like nucleoprotein HC2
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05532 (2/2) CsbD-like
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03780 (2/2) Asp23 family, cell envelope-related function
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00741 (2/2) Gas vesicle protein
precursor_jaccard_groups_24630 175.99 +- 57.04 2 0 2 2 0.09 +- 0.18 2 22

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF11188 (2/2) Protein of unknown function (DUF2975)
PF08592 (2/2) Domain of unknown function (DUF1772)
PF07883 (2/2) Cupin domain
PF04673 (2/2) Polyketide synthesis cyclase
PF04672 (2/2) S-adenosyl methyltransferase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03704 (2/2) Bacterial transcriptional activator domain
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01850 (2/2) PIN domain
PF00931 (2/2) NB-ARC domain
PF00854 (2/2) POT family
PF00733 (2/2) Asparagine synthase
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_9598 29.25 +- 0.75 2 0 2 0 0.12 +- 0.13 2 6

TIGR00377 (2/2) anti-anti-sigma factor
PF13466 (2/2) STAS domain
PF04191 (2/2) Phospholipid methyltransferase
PF02541 (2/2) Ppx/GppA phosphatase family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_710 2247.66 +- 1896.14 43 0 11 0 0.02 +- 0.09 43 10

PF17914 (43/43) HopA1 effector protein family
PF00664 (43/43) ABC transporter transmembrane region
PF00296 (43/43) Luciferase-like monooxygenase
PF00005 (43/43) ABC transporter
PF02441 (42/43) Flavoprotein
PF00675 (41/43) Insulinase (Peptidase family M16)
PF05193 (37/43) Peptidase M16 inactive domain
PF01636 (37/43) Phosphotransferase enzyme family
PF00891 (37/43) O-methyltransferase domain
PF12698 (24/43) ABC-2 family transporter protein
precursor_jaccard_groups_935 80.32 +- 35.78 2 0 0 0 0.14 +- 0.11 2 4

PF13649 (2/2) Methyltransferase domain
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00872 (1/2) Transposase, Mutator family
precursor_jaccard_groups_10695 533.76 +- 91.96 5 0 5 0 0.01 +- 0.00 5 6

PF13640 (5/5) 2OG-Fe(II) oxygenase superfamily
PF13350 (5/5) Tyrosine phosphatase family
PF07690 (5/5) Major Facilitator Superfamily
PF01142 (5/5) tRNA pseudouridine synthase D (TruD)
PF00275 (5/5) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00106 (5/5) short chain dehydrogenase
precursor_jaccard_groups_938 58.68 +- 31.24 9 0 0 0 0.04 +- 0.04 9 2

PF03372 (9/9) Endonuclease/Exonuclease/phosphatase family
PF00583 (9/9) Acetyltransferase (GNAT) family
precursor_jaccard_groups_10697 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_23358 51.21 +- 6.05 3 0 0 0 0.08 +- 0.07 3 5

PF13649 (3/3) Methyltransferase domain
PF11706 (3/3) CGNR zinc finger
PF08445 (3/3) FR47-like protein
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07336 (3/3) Putative stress-induced transcription regulator
precursor_jaccard_groups_20005 65.82 +- 0.00 2 0 0 0 0.15 +- 0.17 2 9

TIGR03723 (2/2) tRNA threonylcarbamoyl adenosine modification protein TsaD
TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02272 (2/2) DHHA1 domain
PF01475 (2/2) Ferric uptake regulator family
PF01411 (2/2) tRNA synthetases class II (A)
PF00814 (2/2) Glycoprotease family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_2900 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_32770 20.67 +- 2.10 2 0 0 0 0.10 +- 0.10 2 3

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_4578 18.53 +- 4.88 9 0 0 0 0.23 +- 0.36 9 11

TIGR02103 (9/9) alpha-1,6-glucosidases, pullulanase-type
PF17967 (9/9) Pullulanase N2 domain
PF11852 (9/9) Domain of unknown function (DUF3372)
PF07228 (9/9) Stage II sporulation protein E (SpoIIE)
PF03714 (9/9) Bacterial pullanase-associated domain
PF02962 (9/9) 5-carboxymethyl-2-hydroxymuconate isomerase
PF02922 (9/9) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (9/9) Alpha amylase, C-terminal all-beta domain
PF00686 (9/9) Starch binding domain
PF00128 (9/9) Alpha amylase, catalytic domain
PF00072 (9/9) Response regulator receiver domain
precursor_jaccard_groups_5005 524.78 +- 612.66 9 0 9 0 0.05 +- 0.16 9 11

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
TIGR00652 (9/9) diaminopimelate epimerase
PF18130 (9/9) ATP-grasp N-terminal domain
PF14518 (9/9) Iron-containing redox enzyme
PF13535 (9/9) ATP-grasp domain
PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF10014 (9/9) 2OG-Fe dioxygenase
PF07690 (9/9) Major Facilitator Superfamily
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01678 (9/9) Diaminopimelate epimerase
PF00155 (9/9) Aminotransferase class I and II
precursor_jaccard_groups_11470 234.00 +- 26.00 2 0 0 2 0.01 +- 0.01 2 5

TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_18041 95.94 +- 24.92 3 0 0 0 0.03 +- 0.02 3 4

PF13649 (3/3) Methyltransferase domain
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
precursor_jaccard_groups_19264 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_18829 125.03 +- 36.02 3 0 3 0 0.14 +- 0.30 3 21

TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF14765 (2/3) Polyketide synthase dehydratase
PF08990 (2/3) Erythronolide synthase docking
PF08659 (2/3) KR domain
PF08044 (2/3) Domain of unknown function (DUF1707)
precursor_jaccard_groups_18826 29.18 +- 7.68 2 0 0 0 0.07 +- 0.05 2 2

PF13649 (2/2) Methyltransferase domain
PF00484 (2/2) Carbonic anhydrase
precursor_jaccard_groups_8881 78.20 +- 29.31 4 0 4 0 0.19 +- 0.20 4 20

TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00566 (4/4) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (4/4) aminodeoxychorismate synthase, component I
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF04715 (4/4) Anthranilate synthase component I, N terminal region
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01061 (4/4) ABC-2 type transporter
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00425 (4/4) chorismate binding enzyme
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_6663 229.78 +- 39.91 3 0 0 0 0.01 +- 0.00 3 6

TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/3) Glycosyl hydrolase family 92
PF07488 (3/3) Glycosyl hydrolase family 67 middle domain
PF07477 (3/3) Glycosyl hydrolase family 67 C-terminus
PF00754 (3/3) F5/8 type C domain
precursor_jaccard_groups_8228 29.54 +- 15.29 6 0 4 0 0.13 +- 0.15 6 9

PF14361 (6/6) RsbT co-antagonist protein rsbRD N-terminal domain
PF13581 (6/6) Histidine kinase-like ATPase domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF06348 (6/6) Protein of unknown function (DUF1059)
PF04545 (6/6) Sigma-70, region 4
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (6/6) STAS domain
PF00512 (6/6) His Kinase A (phospho-acceptor) domain
PF00072 (6/6) Response regulator receiver domain
precursor_jaccard_groups_9287 817.68 +- 534.83 5 0 5 0 0.03 +- 0.12 5 25

TIGR01821 (5/5) 5-aminolevulinic acid synthase
TIGR01733 (5/5) amino acid adenylation domain
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF13535 (5/5) ATP-grasp domain
PF13424 (5/5) Tetratricopeptide repeat
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (5/5) Major Facilitator Superfamily
PF05977 (5/5) Transmembrane secretion effector
PF03704 (5/5) Bacterial transcriptional activator domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02655 (5/5) ATP-grasp domain
PF01212 (5/5) Beta-eliminating lyase
PF00975 (5/5) Thioesterase domain
PF00931 (5/5) NB-ARC domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00487 (5/5) Fatty acid desaturase
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00288 (5/5) GHMP kinases N terminal domain
PF00206 (5/5) Lyase
PF00155 (5/5) Aminotransferase class I and II
precursor_jaccard_groups_6591 77.74 +- 21.24 7 0 0 0 0.03 +- 0.04 7 6

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (7/7) FAD binding domain
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
PF13669 (4/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_15186 32.88 +- 17.35 3 0 0 0 0.11 +- 0.11 3 7

PF18448 (3/3) Carbohydrate binding domain
PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF03442 (3/3) Carbohydrate binding domain X2
PF03330 (3/3) Lytic transglycolase
PF02065 (3/3) Melibiase
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_15185 209.52 +- 69.97 3 0 0 0 0.01 +- 0.01 3 3

TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF04072 (3/3) Leucine carboxyl methyltransferase
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_13656 392.47 +- 335.56 3 0 3 0 0.06 +- 0.17 3 19

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF14525 (3/3) AraC-binding-like domain
PF13349 (3/3) Putative adhesin
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12833 (3/3) Helix-turn-helix domain
PF05977 (3/3) Transmembrane secretion effector
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF03176 (3/3) MMPL family
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01022 (3/3) Bacterial regulatory protein, arsR family
PF00975 (3/3) Thioesterase domain
PF00931 (3/3) NB-ARC domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00144 (3/3) Beta-lactamase
precursor_jaccard_groups_13659 3050.28 +- 2074.67 4 0 4 4 0.01 +- 0.00 4 10

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00005 (4/4) ABC transporter
PF12679 (2/4) ABC-2 family transporter protein
precursor_jaccard_groups_27279 1297.58 +- 1172.42 2 0 2 0 0.08 +- 0.23 2 17

TIGR01746 (2/2) thioester reductase domain
PF17920 (2/2) Tetracyclin repressor-like, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF08031 (2/2) Berberine and berberine like
PF07993 (2/2) Male sterility protein
PF04820 (2/2) Tryptophan halogenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01061 (2/2) ABC-2 type transporter
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_jaccard_groups_23127 107.00 +- 23.87 2 0 0 0 0.20 +- 0.27 2 20

TIGR03356 (2/2) beta-galactosidase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00977 (2/2) citramalate synthase
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08502 (2/2) LeuA allosteric (dimerisation) domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF02983 (2/2) Alpha-lytic protease prodomain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00682 (2/2) HMGL-like
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00005 (2/2) ABC transporter
PF04371 (1/2) Porphyromonas-type peptidyl-arginine deiminase
precursor_jaccard_groups_1485 64.47 +- 15.74 3 0 3 0 0.03 +- 0.02 3 1

PF01494 (3/3) FAD binding domain
precursor_jaccard_groups_41440 124.18 +- 2.31 2 0 1 0 0.12 +- 0.27 2 12

TIGR03841 (2/2) probable F420-dependent oxidoreductase, Rv3093c family
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_14692 88.53 +- 21.64 4 0 0 0 0.02 +- 0.03 4 3

PF06259 (4/4) Alpha/beta hydrolase
PF04149 (4/4) Domain of unknown function (DUF397)
PF01810 (4/4) LysE type translocator
precursor_jaccard_groups_12692 666.50 +- 508.70 3 0 3 0 0.04 +- 0.12 3 12

TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_12694 473.18 +- 329.18 3 0 3 0 0.08 +- 0.18 3 18

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03704 (3/3) Bacterial transcriptional activator domain
PF03466 (3/3) LysR substrate binding domain
PF03176 (3/3) MMPL family
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01323 (3/3) DSBA-like thioredoxin domain
PF01061 (3/3) ABC-2 type transporter
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_8138 142.35 +- 168.39 6 0 0 6 0.03 +- 0.01 6 4

PF13480 (6/6) Acetyltransferase (GNAT) domain
PF04055 (6/6) Radical SAM superfamily
PF02492 (6/6) CobW/HypB/UreG, nucleotide-binding domain
PF13847 (5/6) Methyltransferase domain
precursor_jaccard_groups_1063 142.19 +- 116.53 16 0 0 0 0.08 +- 0.08 16 7

PF05922 (16/16) Peptidase inhibitor I9
PF00082 (16/16) Subtilase family
PF14534 (15/16) Domain of unknown function (DUF4440)
PF08002 (15/16) Protein of unknown function (DUF1697)
PF00664 (11/16) ABC transporter transmembrane region
PF00005 (10/16) ABC transporter
PF01323 (8/16) DSBA-like thioredoxin domain
precursor_jaccard_groups_7953 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
precursor_jaccard_groups_19405 481.00 +- 41.72 3 0 0 0 0.02 +- 0.02 3 7

PF07940 (3/3) Heparinase II/III-like protein
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
precursor_jaccard_groups_4680 208.79 +- 64.06 5 0 0 0 0.02 +- 0.01 5 4

PF13454 (5/5) FAD-NAD(P)-binding
PF07969 (5/5) Amidohydrolase family
PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
precursor_jaccard_groups_27053 518.00 +- 2.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR00013 (2/2) 4-oxalocrotonate tautomerase family enzyme
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF03928 (2/2) Haem-degrading
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01361 (2/2) Tautomerase enzyme
precursor_jaccard_groups_4685 19.00 +- 3.72 7 0 7 0 0.11 +- 0.07 7 4

PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (7/7) Conserved region in glutamate synthase
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_10270 75.00 +- 3.00 2 0 0 0 0.08 +- 0.15 2 4

PF13520 (2/2) Amino acid permease
PF01636 (2/2) Phosphotransferase enzyme family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_jaccard_groups_33489 107.64 +- 9.63 2 0 2 0 0.09 +- 0.23 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13424 (2/2) Tetratricopeptide repeat
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12770 (2/2) CHAT domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07681 (2/2) DoxX
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13808 (1/2) DDE_Tnp_1-associated
PF13545 (1/2) Crp-like helix-turn-helix domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01609 (1/2) Transposase DDE domain
precursor_jaccard_groups_12743 75.94 +- 58.69 3 0 0 0 0.08 +- 0.07 3 9

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF02057 (3/3) Glycosyl hydrolase family 59
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF17801 (2/3) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/3) Alpha galactosidase A
PF13472 (2/3) GDSL-like Lipase/Acylhydrolase family
PF09206 (2/3) Alpha-L-arabinofuranosidase B, catalytic
PF01229 (2/3) Glycosyl hydrolases family 39
PF01120 (2/3) Alpha-L-fucosidase
precursor_jaccard_groups_1668 24.76 +- 8.08 21 0 4 0 0.14 +- 0.05 21 4

TIGR01691 (21/21) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (21/21) ARD/ARD' family
PF00596 (21/21) Class II Aldolase and Adducin N-terminal domain
TIGR03328 (19/21) methylthioribulose-1-phosphate dehydratase
precursor_jaccard_groups_22115 26.26 +- 10.40 3 0 0 0 0.14 +- 0.23 3 3

PF13649 (3/3) Methyltransferase domain
PF00089 (3/3) Trypsin
PF04978 (2/3) Protein of unknown function (DUF664)
precursor_jaccard_groups_5176 35.72 +- 11.71 5 0 0 0 0.20 +- 0.20 5 13

TIGR00045 (5/5) glycerate kinase
PF13517 (5/5) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (5/5) Acetyltransferase (GNAT) domain
PF12867 (5/5) DinB superfamily
PF07690 (5/5) Major Facilitator Superfamily
PF02595 (5/5) Glycerate kinase family
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (5/5) Sodium:sulfate symporter transmembrane region
PF00672 (5/5) HAMP domain
PF00512 (5/5) His Kinase A (phospho-acceptor) domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00089 (5/5) Trypsin
PF00072 (5/5) Response regulator receiver domain
precursor_jaccard_groups_20885 181.12 +- 108.72 3 0 0 0 0.03 +- 0.05 3 3

PF14759 (3/3) Reductase C-terminal
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_26454 680.25 +- 99.75 2 0 2 0 0.01 +- 0.00 2 8

PF08031 (2/2) Berberine and berberine like
PF06236 (2/2) Tyrosinase co-factor MelC1
PF03704 (2/2) Bacterial transcriptional activator domain
PF01565 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00264 (2/2) Common central domain of tyrosinase
PF00221 (2/2) Aromatic amino acid lyase
precursor_jaccard_groups_4194 41.42 +- 16.41 9 0 0 0 0.12 +- 0.24 9 5

PF03450 (9/9) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (9/9) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (9/9) [2Fe-2S] binding domain
PF01315 (9/9) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (9/9) FAD binding domain in molybdopterin dehydrogenase
precursor_jaccard_groups_30452 559.00 +- 215.00 2 0 2 0 0.01 +- 0.01 2 10

PF13424 (2/2) Tetratricopeptide repeat
PF13394 (2/2) 4Fe-4S single cluster domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00931 (2/2) NB-ARC domain
PF00478 (2/2) IMP dehydrogenase / GMP reductase domain
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_30458 22.49 +- 4.60 2 0 0 0 0.14 +- 0.07 2 5

TIGR02798 (2/2) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF04909 (2/2) Amidohydrolase
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_8402 101.38 +- 64.90 2 0 0 0 0.08 +- 0.21 2 10

TIGR00369 (2/2) uncharacterized domain 1
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03061 (2/2) Thioesterase superfamily
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_8401 193.05 +- 0.00 2 0 0 0 0.14 +- 0.11 2 9

PF17939 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13796 (2/2) Putative sensor
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07730 (2/2) Histidine kinase
PF01047 (2/2) MarR family
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_19081 39.79 +- 9.21 3 0 3 0 0.13 +- 0.20 3 11

PF13478 (3/3) XdhC Rossmann domain
PF07728 (3/3) AAA domain (dynein-related subfamily)
PF06240 (3/3) Carbon monoxide dehydrogenase subunit G (CoxG)
PF05762 (3/3) VWA domain containing CoxE-like protein
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_30921 720.96 +- 53.62 2 0 0 0 0.02 +- 0.00 2 11

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01425 (2/2) Amidase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR02713 (1/2) allophanate hydrolase
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF00455 (1/2) DeoR C terminal sensor domain
precursor_jaccard_groups_37252 451.50 +- 64.50 2 0 2 0 0.01 +- 0.00 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
precursor_jaccard_groups_21133 48.41 +- 31.27 2 0 1 0 0.16 +- 0.14 2 10

PF17648 (2/2) Family of unknown function (DUF5519)
PF13377 (2/2) Periplasmic binding protein-like domain
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (2/2) Glycosyl hydrolase family 12
PF00553 (2/2) Cellulose binding domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF13569 (1/2) Domain of unknown function (DUF4132)
PF13411 (1/2) MerR HTH family regulatory protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF02767 (1/2) DNA polymerase III beta subunit, central domain
precursor_jaccard_groups_12520 133.25 +- 36.69 4 0 0 4 0.10 +- 0.11 4 24

TIGR03104 (4/4) asparagine synthase family amidotransferase
TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
TIGR01662 (4/4) HAD hydrolase, family IIIA
PF13537 (4/4) Glutamine amidotransferase domain
PF13242 (4/4) HAD-hyrolase-like
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF07676 (4/4) WD40-like Beta Propeller Repeat
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF01075 (4/4) Glycosyltransferase family 9 (heptosyltransferase)
PF00733 (4/4) Asparagine synthase
PF00535 (4/4) Glycosyl transferase family 2
PF00455 (4/4) DeoR C terminal sensor domain
PF00326 (4/4) Prolyl oligopeptidase family
PF13641 (3/4) Glycosyltransferase like family 2
TIGR02199 (2/4) bifunctional protein RfaE, domain II
PF16861 (2/4) Carbamoyltransferase C-terminus
PF13580 (2/4) SIS domain
PF13439 (2/4) Glycosyltransferase Family 4
PF02543 (2/4) Carbamoyltransferase N-terminus
PF01467 (2/4) Cytidylyltransferase-like
PF01370 (2/4) NAD dependent epimerase/dehydratase family
PF00534 (2/4) Glycosyl transferases group 1
PF00294 (2/4) pfkB family carbohydrate kinase
precursor_jaccard_groups_13838 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_12522 258.50 +- 0.87 4 0 0 0 0.01 +- 0.00 4 6

PF17390 (4/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (4/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (4/4) Alpha-L-rhamnosidase N-terminal domain
PF05592 (4/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00355 (4/4) Rieske [2Fe-2S] domain
precursor_jaccard_groups_1111 532.62 +- 299.32 30 0 0 0 0.02 +- 0.02 30 7

PF17914 (30/30) HopA1 effector protein family
PF05193 (30/30) Peptidase M16 inactive domain
PF00675 (30/30) Insulinase (Peptidase family M16)
PF13649 (29/30) Methyltransferase domain
PF02441 (29/30) Flavoprotein
PF00296 (25/30) Luciferase-like monooxygenase
PF00005 (23/30) ABC transporter
precursor_jaccard_groups_11252 76.51 +- 41.30 4 0 4 0 0.05 +- 0.06 4 7

PF12728 (4/4) Helix-turn-helix domain
PF07995 (4/4) Glucose / Sorbosone dehydrogenase
PF06283 (4/4) Trehalose utilisation
PF03422 (4/4) Carbohydrate binding module (family 6)
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00801 (4/4) PKD domain
PF00589 (4/4) Phage integrase family
precursor_jaccard_groups_7549 265.18 +- 68.33 6 0 0 0 0.06 +- 0.06 6 7

PF17851 (6/6) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF04616 (6/6) Glycosyl hydrolases family 43
PF02826 (6/6) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_38430 64.36 +- 29.46 2 0 0 0 0.16 +- 0.31 2 10

TIGR01788 (2/2) glutamate decarboxylase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13560 (2/2) Helix-turn-helix domain
PF13365 (2/2) Trypsin-like peptidase domain
PF10901 (2/2) Protein of unknown function (DUF2690)
PF07690 (2/2) Major Facilitator Superfamily
PF03358 (2/2) NADPH-dependent FMN reductase
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_4758 125.65 +- 72.69 3 0 0 0 0.06 +- 0.16 3 13

TIGR00034 (3/3) 3-deoxy-7-phosphoheptulonate synthase
PF13458 (3/3) Periplasmic binding protein
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF07732 (3/3) Multicopper oxidase
PF07731 (3/3) Multicopper oxidase
PF01494 (3/3) FAD binding domain
PF01474 (3/3) Class-II DAHP synthetase family
PF00793 (3/3) DAHP synthetase I family
PF00501 (3/3) AMP-binding enzyme
PF13191 (2/3) AAA ATPase domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_27986 116.24 +- 12.76 2 0 0 0 0.12 +- 0.18 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
PF13577 (1/2) SnoaL-like domain
precursor_jaccard_groups_39589 323.00 +- 193.00 2 0 0 0 0.05 +- 0.07 2 5

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (2/2) MDMPI C-terminal domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04672 (1/2) S-adenosyl methyltransferase
precursor_jaccard_groups_27988 52.52 +- 39.62 2 0 0 0 0.13 +- 0.27 2 10

TIGR01167 (2/2) LPXTG cell wall anchor domain
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01872 (2/2) RibD C-terminal domain
PF01590 (2/2) GAF domain
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00989 (2/2) PAS fold
PF00465 (2/2) Iron-containing alcohol dehydrogenase
precursor_jaccard_groups_16997 62.94 +- 7.17 3 0 0 0 0.16 +- 0.12 3 7

PF13601 (3/3) Winged helix DNA-binding domain
PF12698 (3/3) ABC-2 family transporter protein
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00135 (3/3) Carboxylesterase family
PF00005 (3/3) ABC transporter
PF01497 (2/3) Periplasmic binding protein
PF01032 (2/3) FecCD transport family
precursor_jaccard_groups_19885 482.02 +- 29.43 3 0 0 0 0.02 +- 0.03 3 10

PF12833 (3/3) Helix-turn-helix domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02311 (3/3) AraC-like ligand binding domain
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00664 (3/3) ABC transporter transmembrane region
PF00561 (3/3) alpha/beta hydrolase fold
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_9015 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
precursor_jaccard_groups_26903 20.21 +- 2.07 2 0 0 0 0.15 +- 0.11 2 8

PF18050 (2/2) Cyclophilin-like family
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13359 (2/2) DDE superfamily endonuclease
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_12230 95.81 +- 27.93 4 0 0 0 0.17 +- 0.19 4 9

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (4/4) virulence factor Mce family protein
PF13406 (4/4) Transglycosylase SLT domain
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (4/4) Sigma-70, region 4
PF04542 (4/4) Sigma-70 region 2
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_44528 135.29 +- 122.71 2 0 0 0 0.08 +- 0.11 2 2

PF13458 (2/2) Periplasmic binding protein
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_141 78.94 +- 144.02 89 0 89 0 0.15 +- 0.23 89 12

TIGR03025 (89/89) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (89/89) Glycosyl transferases group 1
PF13480 (89/89) Acetyltransferase (GNAT) domain
PF13439 (89/89) Glycosyltransferase Family 4
PF04932 (89/89) O-Antigen ligase
PF03777 (89/89) ChpA-C
PF03023 (89/89) Lipid II flippase MurJ
PF02397 (89/89) Bacterial sugar transferase
PF01522 (89/89) Polysaccharide deacetylase
PF00534 (89/89) Glycosyl transferases group 1
PF00348 (73/89) Polyprenyl synthetase
PF00857 (46/89) Isochorismatase family
precursor_jaccard_groups_21599 46.49 +- 20.71 3 0 0 0 0.08 +- 0.08 3 5

PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09335 (3/3) SNARE associated Golgi protein
PF07532 (3/3) Bacterial Ig-like domain (group 4)
PF04616 (3/3) Glycosyl hydrolases family 43
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_17624 308.15 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

PF18631 (2/2) Cucumopine synthase C-terminal helical bundle domain
PF13546 (2/2) DDE superfamily endonuclease
PF02195 (2/2) ParB-like nuclease domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_25239 80.95 +- 7.19 2 0 0 0 0.12 +- 0.08 2 9

TIGR00052 (2/2) nudix-type nucleoside diphosphatase, YffH/AdpP family
PF17912 (2/2) MalK OB fold domain
PF04248 (2/2) Domain of unknown function (DUF427)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01230 (2/2) HIT domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00293 (2/2) NUDIX domain
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_17623 208.00 +- 159.49 3 0 0 0 0.03 +- 0.06 3 6

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01569 (3/3) PAP2 superfamily
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00282 (3/3) Pyridoxal-dependent decarboxylase conserved domain
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_26322 7843.20 +- 6508.80 2 0 2 2 0.05 +- 0.15 2 21

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_jaccard_groups_29694 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_29695 200.54 +- 186.46 2 0 0 0 0.07 +- 0.14 2 8

PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF11361 (2/2) Protein of unknown function (DUF3159)
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00667 (1/2) FAD binding domain
PF00258 (1/2) Flavodoxin
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_17820 556.00 +- 402.80 3 0 0 0 0.03 +- 0.06 3 12

TIGR01409 (3/3) Tat (twin-arginine translocation) pathway signal sequence
PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (3/3) Major Facilitator Superfamily
PF04616 (3/3) Glycosyl hydrolases family 43
PF02449 (3/3) Beta-galactosidase
PF00801 (3/3) PKD domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_5765 67.51 +- 6.49 6 0 6 0 0.12 +- 0.12 6 22

TIGR01733 (6/6) amino acid adenylation domain
TIGR01048 (6/6) diaminopimelate decarboxylase
PF16884 (6/6) N-terminal domain of oxidoreductase
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF14765 (6/6) Polyketide synthase dehydratase
PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08659 (6/6) KR domain
PF07690 (6/6) Major Facilitator Superfamily
PF04116 (6/6) Fatty acid hydroxylase superfamily
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02784 (6/6) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01593 (6/6) Flavin containing amine oxidoreductase
PF01266 (6/6) FAD dependent oxidoreductase
PF00975 (6/6) Thioesterase domain
PF00698 (6/6) Acyl transferase domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00107 (6/6) Zinc-binding dehydrogenase
PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_20550 22.97 +- 12.22 2 0 2 0 0.13 +- 0.14 2 3

PF06236 (2/2) Tyrosinase co-factor MelC1
PF00264 (2/2) Common central domain of tyrosinase
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
precursor_jaccard_groups_16192 325.00 +- 239.00 3 0 0 0 0.03 +- 0.08 3 3

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family
precursor_jaccard_groups_38913 227.50 +- 32.50 2 0 0 0 0.01 +- 0.00 2 2

PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_jaccard_groups_16199 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_5769 175.15 +- 104.09 7 0 7 0 0.03 +- 0.03 7 8

TIGR01733 (7/7) amino acid adenylation domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF01494 (7/7) FAD binding domain
PF00975 (7/7) Thioesterase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00106 (7/7) short chain dehydrogenase
precursor_jaccard_groups_5768 236.78 +- 244.03 6 0 6 0 0.11 +- 0.24 6 24

TIGR01733 (6/6) amino acid adenylation domain
TIGR01686 (6/6) FkbH domain
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05977 (6/6) Transmembrane secretion effector
PF03621 (6/6) MbtH-like protein
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (6/6) Periplasmic binding protein
PF01032 (6/6) FecCD transport family
PF00975 (6/6) Thioesterase domain
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00005 (6/6) ABC transporter
PF07690 (5/6) Major Facilitator Superfamily
precursor_jaccard_groups_335 42.57 +- 14.66 3 0 0 0 0.12 +- 0.23 3 13

TIGR00254 (3/3) diguanylate cyclase (GGDEF) domain
PF14659 (3/3) Phage integrase, N-terminal SAM-like domain
PF13148 (3/3) Protein of unknown function (DUF3987)
PF00990 (3/3) Diguanylate cyclase, GGDEF domain
PF00589 (3/3) Phage integrase family
TIGR01764 (2/3) DNA binding domain, excisionase family
PF13349 (2/3) Putative adhesin
PF13102 (2/3) Phage integrase SAM-like domain
PF12728 (2/3) Helix-turn-helix domain
PF09339 (2/3) IclR helix-turn-helix domain
PF09250 (2/3) Bifunctional DNA primase/polymerase, N-terminal
PF07690 (2/3) Major Facilitator Superfamily
PF05362 (2/3) Lon protease (S16) C-terminal proteolytic domain
precursor_jaccard_groups_337 49.97 +- 24.68 9 0 0 0 0.08 +- 0.14 9 6

TIGR00254 (9/9) diguanylate cyclase (GGDEF) domain
PF00990 (9/9) Diguanylate cyclase, GGDEF domain
PF12728 (8/9) Helix-turn-helix domain
PF10935 (8/9) Protein of unknown function (DUF2637)
PF09250 (6/9) Bifunctional DNA primase/polymerase, N-terminal
PF00589 (6/9) Phage integrase family
precursor_jaccard_groups_38047 222.57 +- 67.66 2 0 0 0 0.07 +- 0.04 2 12

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF04952 (1/2) Succinylglutamate desuccinylase / Aspartoacylase family
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III
precursor_jaccard_groups_6919 233.43 +- 45.78 7 0 0 0 0.01 +- 0.00 7 9

PF18310 (7/7) Domain of unknown function (DUF5605)
PF17851 (7/7) Beta xylosidase C-terminal Concanavalin A-like domain
PF17390 (7/7) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (7/7) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16586 (7/7) Domain of unknown function (DUF5060)
PF13204 (7/7) Protein of unknown function (DUF4038)
PF08531 (7/7) Alpha-L-rhamnosidase N-terminal domain
PF05592 (7/7) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF04616 (7/7) Glycosyl hydrolases family 43
precursor_jaccard_groups_483 18.12 +- 2.41 3 0 0 0 0.20 +- 0.25 3 7

PF17928 (3/3) Tetracyclin repressor-like, C-terminal domain
PF08402 (3/3) TOBE domain
PF04879 (3/3) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00384 (3/3) Molybdopterin oxidoreductase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_4360 12.36 +- 0.48 7 0 0 0 0.24 +- 0.38 7 5

TIGR01549 (7/7) HAD hydrolase, family IA, variant 1
PF17197 (7/7) Domain of unknown function (DUF5134)
PF01569 (7/7) PAP2 superfamily
PF01435 (7/7) Peptidase family M48
PF00702 (7/7) haloacid dehalogenase-like hydrolase
precursor_jaccard_groups_6913 41.66 +- 0.48 4 0 0 0 0.22 +- 0.14 4 8

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08533 (4/4) Beta-galactosidase C-terminal domain
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_4364 227.53 +- 174.07 3 0 0 0 0.06 +- 0.13 3 4

TIGR01382 (3/3) intracellular protease, PfpI family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03928 (3/3) Haem-degrading
PF01965 (3/3) DJ-1/PfpI family
precursor_jaccard_groups_25349 163.67 +- 94.33 2 0 0 0 0.02 +- 0.01 2 4

PF12697 (2/2) Alpha/beta hydrolase family
PF10012 (2/2) Uncharacterized protein conserved in bacteria (DUF2255)
PF01738 (2/2) Dienelactone hydrolase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_25587 193.50 +- 0.00 2 0 2 0 0.03 +- 0.01 2 5

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_28789 22.15 +- 0.95 2 0 0 0 0.14 +- 0.16 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_jaccard_groups_20556 237.28 +- 57.47 3 0 0 0 0.06 +- 0.09 3 15

TIGR01451 (3/3) conserved repeat domain
TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF18029 (3/3) Glyoxalase-like domain
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF12831 (3/3) FAD dependent oxidoreductase
PF07971 (3/3) Glycosyl hydrolase family 92
PF07730 (3/3) Histidine kinase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_17958 698.29 +- 358.70 3 0 0 0 0.02 +- 0.03 3 7

PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF03704 (3/3) Bacterial transcriptional activator domain
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_jaccard_groups_40173 86.67 +- 0.00 2 0 2 0 0.02 +- 0.00 2 4

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_5966 260.42 +- 92.40 7 0 0 7 0.04 +- 0.10 7 4

PF04828 (7/7) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (7/7) Amidinotransferase
PF00999 (7/7) Sodium/hydrogen exchanger family
PF00881 (7/7) Nitroreductase family
precursor_jaccard_groups_20663 60.14 +- 48.71 2 0 0 0 0.13 +- 0.12 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00672 (2/2) HAMP domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
precursor_jaccard_groups_5969 34.14 +- 8.86 7 0 0 0 0.14 +- 0.23 7 8

PF14200 (7/7) Ricin-type beta-trefoil lectin domain-like
PF03777 (7/7) ChpA-C
PF01494 (7/7) FAD binding domain
PF00459 (7/7) Inositol monophosphatase family
PF00754 (6/7) F5/8 type C domain
PF09130 (5/7) Domain of unknown function (DUF1932)
PF00106 (5/7) short chain dehydrogenase
PF03446 (4/7) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_29473 61.31 +- 24.17 2 0 0 0 0.11 +- 0.07 2 9

TIGR01217 (2/2) acetoacetate-CoA ligase
PF16177 (2/2) Acetyl-coenzyme A synthetase N-terminus
PF13564 (2/2) DoxX-like family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (2/2) AMP-binding enzyme
PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_7652 17.22 +- 5.22 2 0 0 0 0.13 +- 0.12 2 6

PF13600 (2/2) N-terminal domain of unknown function (DUF4140)
PF13598 (2/2) Domain of unknown function (DUF4139)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain
TIGR02231 (1/2) conserved hypothetical protein
precursor_jaccard_groups_24983 40.00 +- 0.00 2 0 0 0 0.10 +- 0.22 2 6

PF13361 (2/2) UvrD-like helicase C-terminal domain
PF13245 (2/2) AAA domain
PF09369 (2/2) Domain of unknown function (DUF1998)
PF04851 (2/2) Type III restriction enzyme, res subunit
PF00296 (2/2) Luciferase-like monooxygenase
PF00271 (2/2) Helicase conserved C-terminal domain
precursor_jaccard_groups_16688 311.06 +- 166.74 3 0 0 0 0.02 +- 0.01 3 10

PF16349 (3/3) Domain of unknown function (DUF4978)
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF14100 (3/3) Methane oxygenase PmoA
PF13377 (3/3) Periplasmic binding protein-like domain
PF13338 (3/3) Transcriptional regulator, AbiEi antitoxin
PF07883 (3/3) Cupin domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_15978 123.98 +- 106.19 2 0 2 0 0.10 +- 0.21 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02195 (2/2) ParB-like nuclease domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08242 (1/2) Methyltransferase domain
PF04820 (1/2) Tryptophan halogenase
PF03621 (1/2) MbtH-like protein
PF00999 (1/2) Sodium/hydrogen exchanger family
PF00975 (1/2) Thioesterase domain
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_16682 33.15 +- 2.48 3 0 0 0 0.12 +- 0.07 3 7

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_29902 225.00 +- 165.00 2 0 0 2 0.03 +- 0.04 2 5

PF13671 (2/2) AAA domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF04055 (2/2) Radical SAM superfamily
PF01928 (2/2) CYTH domain
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_153 111.54 +- 105.83 3 0 0 3 0.07 +- 0.11 3 11

TIGR04276 (3/3) FxsC C-terminal domain
TIGR04269 (3/3) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (3/3) FXSXX-COOH protein
TIGR04267 (3/3) HEXXH motif domain
PF13676 (3/3) TIR domain
PF13424 (3/3) Tetratricopeptide repeat
PF04055 (3/3) Radical SAM superfamily
PF00931 (3/3) NB-ARC domain
PF13614 (2/3) AAA domain
PF13374 (2/3) Tetratricopeptide repeat
PF02522 (2/3) Aminoglycoside 3-N-acetyltransferase
precursor_jaccard_groups_24182 633.75 +- 400.60 2 0 2 0 0.06 +- 0.14 2 21

TIGR00217 (2/2) 4-alpha-glucanotransferase
TIGR00099 (2/2) Cof-like hydrolase
PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13692 (2/2) Glycosyl transferases group 1
PF08323 (2/2) Starch synthase catalytic domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07883 (2/2) Cupin domain
PF06182 (2/2) ABC-2 family transporter protein
PF05199 (2/2) GMC oxidoreductase
PF04321 (2/2) RmlD substrate binding domain
PF02446 (2/2) 4-alpha-glucanotransferase
PF02057 (2/2) Glycosyl hydrolase family 59
PF01761 (2/2) 3-dehydroquinate synthase
PF00732 (2/2) GMC oxidoreductase
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00248 (2/2) Aldo/keto reductase family
PF00202 (2/2) Aminotransferase class-III
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_14544 104.04 +- 12.83 3 0 0 0 0.03 +- 0.02 3 6

PF12697 (3/3) Alpha/beta hydrolase family
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF01494 (3/3) FAD binding domain
PF01262 (3/3) Alanine dehydrogenase/PNT, C-terminal domain
PF02909 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_17552 114.15 +- 7.92 2 0 2 0 0.10 +- 0.09 2 16

TIGR01662 (2/2) HAD hydrolase, family IIIA
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13580 (2/2) SIS domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13242 (2/2) HAD-hyrolase-like
PF12028 (2/2) Protein of unknown function (DUF3515)
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01467 (2/2) Cytidylyltransferase-like
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR02199 (1/2) bifunctional protein RfaE, domain II
TIGR00125 (1/2) cytidyltransferase-like domain
precursor_jaccard_groups_38131 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_jaccard_groups_24184 82.65 +- 14.85 2 0 0 0 0.11 +- 0.03 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11873 410.25 +- 124.26 4 0 0 0 0.01 +- 0.01 4 6

PF13599 (4/4) Pentapeptide repeats (9 copies)
PF13489 (4/4) Methyltransferase domain
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF08445 (2/4) FR47-like protein
PF07730 (2/4) Histidine kinase
PF00583 (2/4) Acetyltransferase (GNAT) family
precursor_jaccard_groups_11871 125.26 +- 77.54 3 0 0 0 0.04 +- 0.08 3 3

PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF04266 (3/3) ASCH domain
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_jaccard_groups_10874 1086.27 +- 671.10 5 0 0 0 0.01 +- 0.00 5 7

TIGR03921 (5/5) type VII secretion-associated serine protease mycosin
TIGR03919 (5/5) type VII secretion protein EccB
PF06259 (5/5) Alpha/beta hydrolase
PF05108 (5/5) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/5) Subtilase family
TIGR03930 (3/5) WXG100 family type VII secretion target
PF06013 (3/5) Proteins of 100 residues with WXG
precursor_jaccard_groups_24740 14.22 +- 0.78 2 0 0 0 0.21 +- 0.20 2 3

PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF01554 (1/2) MatE
precursor_jaccard_groups_40352 82.76 +- 8.47 2 0 0 0 0.07 +- 0.12 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
TIGR03930 (1/2) WXG100 family type VII secretion target
PF06013 (1/2) Proteins of 100 residues with WXG
precursor_jaccard_groups_29303 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_24747 64.56 +- 19.01 2 0 2 2 0.10 +- 0.24 2 16

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05173 (2/2) Dihydrodipicolinate reductase, C-terminus
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00881 (2/2) Nitroreductase family
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR02246 (1/2) conserved hypothetical protein
TIGR01048 (1/2) diaminopimelate decarboxylase
PF17837 (1/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF14534 (1/2) Domain of unknown function (DUF4440)
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01113 (1/2) Dihydrodipicolinate reductase, N-terminus
PF00899 (1/2) ThiF family
PF00581 (1/2) Rhodanese-like domain
precursor_jaccard_groups_24962 1072.50 +- 214.50 2 0 2 0 0.01 +- 0.01 2 11

PF16861 (2/2) Carbamoyltransferase C-terminus
PF13560 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_15883 155.71 +- 58.32 3 0 0 0 0.04 +- 0.04 3 8

PF07690 (3/3) Major Facilitator Superfamily
PF01596 (3/3) O-methyltransferase
PF01402 (3/3) Ribbon-helix-helix protein, copG family
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00072 (3/3) Response regulator receiver domain
TIGR00027 (2/3) methyltransferase, TIGR00027 family
PF04072 (2/3) Leucine carboxyl methyltransferase
precursor_jaccard_groups_14333 125.56 +- 76.73 4 0 0 0 0.02 +- 0.01 4 4

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain
precursor_jaccard_groups_15887 87.56 +- 21.14 3 0 0 0 0.04 +- 0.01 3 6

TIGR03356 (3/3) beta-galactosidase
PF08329 (3/3) Chitinase A, N-terminal domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00376 (3/3) MerR family regulatory protein
PF00331 (3/3) Glycosyl hydrolase family 10
PF00232 (3/3) Glycosyl hydrolase family 1
precursor_jaccard_groups_45654 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
precursor_jaccard_groups_28895 19.83 +- 2.27 2 0 0 0 0.20 +- 0.36 2 7

TIGR00754 (2/2) bacterioferritin
PF09130 (2/2) Domain of unknown function (DUF1932)
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF00210 (2/2) Ferritin-like domain
PF10400 (1/2) Virulence activator alpha C-term
PF08922 (1/2) Domain of unknown function (DUF1905)
PF03551 (1/2) Transcriptional regulator PadR-like family
precursor_jaccard_groups_28894 145.35 +- 20.51 2 0 0 0 0.06 +- 0.10 2 16

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13466 (2/2) STAS domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00108 (2/2) Thiolase, N-terminal domain
precursor_jaccard_groups_15889 26.35 +- 4.85 2 0 0 0 0.15 +- 0.26 2 8

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF07690 (2/2) Major Facilitator Superfamily
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF05437 (1/2) Branched-chain amino acid transport protein (AzlD)
PF03591 (1/2) AzlC protein
precursor_jaccard_groups_32947 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02223 (2/2) Thymidylate kinase
PF01503 (2/2) Phosphoribosyl-ATP pyrophosphohydrolase
precursor_jaccard_groups_13017 256.01 +- 202.81 3 0 0 0 0.06 +- 0.13 3 3

PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_4962 93.20 +- 26.88 6 0 1 0 0.04 +- 0.02 6 6

PF12697 (6/6) Alpha/beta hydrolase family
PF07729 (6/6) FCD domain
PF06684 (6/6) Amino acid synthesis
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF00296 (6/6) Luciferase-like monooxygenase
PF00171 (6/6) Aldehyde dehydrogenase family
precursor_jaccard_groups_3243 72.45 +- 133.79 12 0 0 12 0.12 +- 0.29 12 7

PF14518 (12/12) Iron-containing redox enzyme
PF04055 (12/12) Radical SAM superfamily
PF03704 (12/12) Bacterial transcriptional activator domain
PF02687 (12/12) FtsX-like permease family
PF00486 (12/12) Transcriptional regulatory protein, C terminal
PF00005 (12/12) ABC transporter
PF12704 (10/12) MacB-like periplasmic core domain
precursor_jaccard_groups_3532 27.62 +- 17.66 6 0 2 0 0.19 +- 0.17 6 21

TIGR00143 (6/6) carbamoyltransferase HypF
TIGR00073 (6/6) hydrogenase accessory protein HypB
TIGR00072 (6/6) hydrogenase maturation protease
PF17788 (6/6) HypF Kae1-like domain
PF14720 (6/6) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (6/6) Protein of unknown function (DUF4232)
PF07503 (6/6) HypF finger
PF02492 (6/6) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (6/6) Hydrogenase maturation protease
PF01300 (6/6) Telomere recombination
PF01155 (6/6) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (6/6) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (6/6) Acylphosphatase
PF00374 (6/6) Nickel-dependent hydrogenase
TIGR02124 (5/6) hydrogenase expression/formation protein HypE
TIGR00075 (5/6) hydrogenase expression/formation protein HypD
TIGR00074 (5/6) hydrogenase assembly chaperone HypC/HupF
PF02769 (5/6) AIR synthase related protein, C-terminal domain
PF01924 (5/6) Hydrogenase formation hypA family
PF01455 (5/6) HupF/HypC family
PF00586 (5/6) AIR synthase related protein, N-terminal domain
precursor_jaccard_groups_16532 9.92 +- 0.40 2 0 0 0 0.20 +- 0.28 2 2

PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_4210 37.66 +- 8.65 5 0 2 0 0.14 +- 0.17 5 8

PF17754 (5/5) MftR C-terminal domain
PF08445 (5/5) FR47-like protein
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter
PF13561 (3/5) Enoyl-(Acyl carrier protein) reductase
precursor_jaccard_groups_27587 388.00 +- 128.00 2 0 2 0 0.02 +- 0.01 2 7

PF13394 (2/2) 4Fe-4S single cluster domain
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00478 (2/2) IMP dehydrogenase / GMP reductase domain
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_6863 38.20 +- 0.50 2 0 0 0 0.10 +- 0.13 2 7

PF12728 (2/2) Helix-turn-helix domain
PF11750 (2/2) Protein of unknown function (DUF3307)
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF05707 (2/2) Zonular occludens toxin (Zot)
PF00589 (2/2) Phage integrase family
PF10935 (1/2) Protein of unknown function (DUF2637)
PF00293 (1/2) NUDIX domain
precursor_jaccard_groups_3249 100.24 +- 85.41 7 0 0 0 0.05 +- 0.09 7 4

PF01243 (7/7) Pyridoxamine 5'-phosphate oxidase
PF00970 (7/7) Oxidoreductase FAD-binding domain
PF00175 (7/7) Oxidoreductase NAD-binding domain
PF00042 (7/7) Globin
precursor_jaccard_groups_19421 431.67 +- 154.38 3 0 3 0 0.01 +- 0.00 3 6

PF03412 (3/3) Peptidase C39 family
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_6867 119.89 +- 53.23 3 0 0 0 0.02 +- 0.01 3 5

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_24364 24.96 +- 11.46 2 0 0 0 0.11 +- 0.11 2 3

PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF00877 (2/2) NlpC/P60 family
PF00535 (1/2) Glycosyl transferase family 2
precursor_jaccard_groups_25762 38.16 +- 4.73 2 0 0 0 0.21 +- 0.36 2 7

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03816 (2/2) helicase/secretion neighborhood TadE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_2598 22.01 +- 5.59 6 0 5 0 0.17 +- 0.21 6 7

PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF11991 (5/6) Tryptophan dimethylallyltransferase
PF01212 (5/6) Beta-eliminating lyase
PF00383 (5/6) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_4988 55.73 +- 16.93 8 0 0 0 0.14 +- 0.18 8 7

TIGR00996 (8/8) virulence factor Mce family protein
PF13406 (8/8) Transglycosylase SLT domain
PF11887 (8/8) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (8/8) MlaD protein
PF02405 (8/8) Permease MlaE
PF00005 (8/8) ABC transporter
PF13577 (5/8) SnoaL-like domain
precursor_jaccard_groups_34910 128.57 +- 41.93 2 0 2 0 0.10 +- 0.26 2 15

TIGR00223 (2/2) aspartate 1-decarboxylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02261 (2/2) Aspartate decarboxylase
PF01613 (2/2) Flavin reductase like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF12697 (1/2) Alpha/beta hydrolase family
PF00561 (1/2) alpha/beta hydrolase fold
precursor_jaccard_groups_34912 274.12 +- 112.88 2 0 2 0 0.01 +- 0.01 2 5

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF00891 (2/2) O-methyltransferase domain
PF13577 (1/2) SnoaL-like domain
precursor_jaccard_groups_4980 43.84 +- 8.75 9 0 0 0 0.17 +- 0.21 9 7

TIGR00996 (9/9) virulence factor Mce family protein
PF13577 (9/9) SnoaL-like domain
PF11887 (9/9) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (9/9) MlaD protein
PF02405 (9/9) Permease MlaE
PF00005 (9/9) ABC transporter
PF13406 (8/9) Transglycosylase SLT domain
precursor_jaccard_groups_4981 93.34 +- 74.16 3 0 0 0 0.20 +- 0.29 3 10

PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
TIGR03177 (2/3) Flp pilus assembly protein CpaB
PF16976 (2/3) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/3) AAA domain
PF07811 (2/3) TadE-like protein
PF00437 (2/3) Type II/IV secretion system protein
precursor_jaccard_groups_40200 102.01 +- 7.46 2 0 0 0 0.04 +- 0.03 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
precursor_jaccard_groups_21243 280.59 +- 151.56 3 0 0 0 0.07 +- 0.06 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF17851 (2/3) Beta xylosidase C-terminal Concanavalin A-like domain
precursor_jaccard_groups_40595 209.46 +- 92.46 2 0 0 0 0.08 +- 0.08 2 11

TIGR01234 (2/2) ribulokinase
PF18029 (2/2) Glyoxalase-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_44670 29.96 +- 2.80 2 0 0 0 0.13 +- 0.06 2 4

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF07045 (2/2) Domain of unknown function (DUF1330)
PF01047 (2/2) MarR family
precursor_jaccard_groups_44899 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_2207 708.41 +- 344.45 17 2 15 17 0.02 +- 0.06 15 8

TIGR03891 (17/17) thiopeptide-type bacteriocin biosynthesis domain
TIGR03731 (17/17) lantibiotic, gallidermin/nisin family
PF14028 (17/17) Lantibiotic biosynthesis dehydratase C-term
PF05147 (17/17) Lanthionine synthetase C-like protein
PF04738 (17/17) Lantibiotic dehydratase, N terminus
PF01061 (17/17) ABC-2 type transporter
PF00005 (17/17) ABC transporter
PF02052 (14/17) Gallidermin
precursor_jaccard_groups_2202 147.48 +- 74.59 17 0 1 0 0.02 +- 0.01 17 2

PF08241 (17/17) Methyltransferase domain
PF00067 (17/17) Cytochrome P450
precursor_jaccard_groups_20086 73.50 +- 30.50 2 0 0 0 0.06 +- 0.05 2 3

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_9498 194.60 +- 87.59 4 0 4 0 0.08 +- 0.20 4 14

TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01245 (4/4) anthranilate phosphoribosyltransferase
TIGR00566 (4/4) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF13432 (4/4) Tetratricopeptide repeat
PF13424 (4/4) Tetratricopeptide repeat
PF04715 (4/4) Anthranilate synthase component I, N terminal region
PF03704 (4/4) Bacterial transcriptional activator domain
PF02885 (4/4) Glycosyl transferase family, helical bundle domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF00931 (4/4) NB-ARC domain
PF00591 (4/4) Glycosyl transferase family, a/b domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00425 (4/4) chorismate binding enzyme
PF00117 (4/4) Glutamine amidotransferase class-I
precursor_jaccard_groups_10474 128.15 +- 18.60 4 0 0 0 0.02 +- 0.01 4 3

PF07582 (4/4) AP endonuclease family 2 C terminus
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (4/4) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_10475 145.36 +- 94.06 5 0 3 5 0.02 +- 0.02 5 2

PF05147 (5/5) Lanthionine synthetase C-like protein
PF00296 (5/5) Luciferase-like monooxygenase
precursor_jaccard_groups_7328 39.43 +- 9.11 5 0 0 0 0.08 +- 0.10 5 6

TIGR02983 (5/5) RNA polymerase sigma-70 factor, sigma-E family
PF13489 (5/5) Methyltransferase domain
PF08281 (5/5) Sigma-70, region 4
PF04978 (5/5) Protein of unknown function (DUF664)
PF04542 (5/5) Sigma-70 region 2
PF13424 (3/5) Tetratricopeptide repeat
precursor_jaccard_groups_43801 117.22 +- 27.91 2 0 2 0 0.05 +- 0.06 2 13

TIGR01426 (2/2) glycosyltransferase, MGT family
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00664 (2/2) ABC transporter transmembrane region
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_13488 88.97 +- 4.84 2 0 2 0 0.04 +- 0.05 2 6

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF01839 (2/2) FG-GAP repeat
precursor_jaccard_groups_40823 72.38 +- 43.72 2 0 2 1 0.18 +- 0.18 2 21

TIGR02050 (2/2) carboxylate-amine ligase, YbdK family
TIGR01382 (2/2) intracellular protease, PfpI family
PF17196 (2/2) Protein of unknown function (DUF5133)
PF13828 (2/2) Domain of unknown function (DUF4190)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF08768 (2/2) Domain of unknown function (DUF1794)
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04954 (2/2) Siderophore-interacting protein
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF03621 (2/2) MbtH-like protein
PF01965 (2/2) DJ-1/PfpI family
PF01594 (2/2) AI-2E family transporter
PF00037 (2/2) 4Fe-4S binding domain
TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF13360 (1/2) PQQ-like domain
PF05406 (1/2) WGR domain
PF03707 (1/2) Bacterial signalling protein N terminal repeat
PF01341 (1/2) Glycosyl hydrolases family 6
PF00942 (1/2) Cellulose binding domain
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_43026 139.29 +- 120.71 2 0 0 0 0.06 +- 0.05 2 2

PF08386 (2/2) TAP-like protein
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_38953 70.22 +- 13.78 2 0 0 0 0.10 +- 0.13 2 10

TIGR04316 (2/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF13546 (2/2) DDE superfamily endonuclease
PF03358 (2/2) NADPH-dependent FMN reductase
PF01494 (2/2) FAD binding domain
PF01474 (2/2) Class-II DAHP synthetase family
PF00857 (2/2) Isochorismatase family
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_42281 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_23698 680.00 +- 35.00 2 0 1 0 0.01 +- 0.02 2 9

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF01636 (2/2) Phosphotransferase enzyme family
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_jaccard_groups_36923 1281.00 +- 525.00 2 0 0 0 0.02 +- 0.02 2 9

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF06889 (2/2) Protein of unknown function (DUF1266)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_3756 15.97 +- 3.83 3 0 0 0 0.13 +- 0.09 3 4

PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF01425 (3/3) Amidase
PF01411 (3/3) tRNA synthetases class II (A)
PF00474 (3/3) Sodium:solute symporter family
precursor_jaccard_groups_39390 164.86 +- 47.86 2 0 0 0 0.04 +- 0.02 2 5

TIGR00784 (2/2) citrate transporter
PF18435 (2/2) Esterase Ig-like N-terminal domain
PF10503 (2/2) Esterase PHB depolymerase
PF03600 (2/2) Citrate transporter
PF00135 (2/2) Carboxylesterase family
precursor_jaccard_groups_23695 56.00 +- 0.39 2 0 2 0 0.14 +- 0.14 2 16

TIGR02353 (2/2) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (2/2) amino acid adenylation domain
TIGR01350 (2/2) dihydrolipoyl dehydrogenase
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13578 (2/2) Methyltransferase domain
PF13520 (2/2) Amino acid permease
PF10009 (2/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF09557 (2/2) Domain of unknown function (DUF2382)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05239 (2/2) PRC-barrel domain
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01433 (2/2) Peptidase family M1 domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF04239 (1/2) Protein of unknown function (DUF421)
precursor_jaccard_groups_11899 241.43 +- 18.57 2 0 0 2 0.01 +- 0.00 2 9

TIGR04276 (2/2) FxsC C-terminal domain
TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13614 (2/2) AAA domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF04055 (2/2) Radical SAM superfamily
PF02522 (2/2) Aminoglycoside 3-N-acetyltransferase
precursor_jaccard_groups_9611 296.86 +- 197.58 5 0 1 0 0.05 +- 0.04 5 11

TIGR01167 (5/5) LPXTG cell wall anchor domain
PF17802 (5/5) Prealbumin-like fold domain
PF16259 (5/5) Domain of unknown function (DUF4913)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF03771 (5/5) Domain of unknown function (DUF317)
PF01638 (5/5) HxlR-like helix-turn-helix
PF00583 (5/5) Acetyltransferase (GNAT) family
PF08239 (4/5) Bacterial SH3 domain
PF01555 (4/5) DNA methylase
PF18130 (3/5) ATP-grasp N-terminal domain
precursor_jaccard_groups_9615 41.86 +- 7.00 3 0 0 0 0.05 +- 0.04 3 5

PF16259 (3/3) Domain of unknown function (DUF4913)
PF12696 (3/3) TraM recognition site of TraD and TraG
PF02882 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01425 (3/3) Amidase
PF00763 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_jaccard_groups_32164 417.11 +- 145.80 2 0 0 0 0.02 +- 0.02 2 5

PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF00857 (2/2) Isochorismatase family
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_929 24.21 +- 5.26 7 0 0 0 0.19 +- 0.31 7 7

PF13560 (7/7) Helix-turn-helix domain
PF09339 (7/7) IclR helix-turn-helix domain
PF04978 (7/7) Protein of unknown function (DUF664)
PF04149 (7/7) Domain of unknown function (DUF397)
PF00005 (7/7) ABC transporter
PF05362 (6/7) Lon protease (S16) C-terminal proteolytic domain
PF00753 (5/7) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_924 38.21 +- 20.04 33 0 0 0 0.11 +- 0.11 33 12

TIGR01524 (33/33) magnesium-translocating P-type ATPase
PF17668 (33/33) Acetyltransferase (GNAT) domain
PF13530 (33/33) Sterol carrier protein domain
PF13527 (33/33) Acetyltransferase (GNAT) domain
PF03466 (33/33) LysR substrate binding domain
PF02308 (33/33) MgtC family
PF01361 (33/33) Tautomerase enzyme
PF00702 (33/33) haloacid dehalogenase-like hydrolase
PF00690 (33/33) Cation transporter/ATPase, N-terminus
PF00689 (33/33) Cation transporting ATPase, C-terminus
PF00126 (33/33) Bacterial regulatory helix-turn-helix protein, lysR family
PF00122 (33/33) E1-E2 ATPase
precursor_jaccard_groups_1873 281.17 +- 144.53 2 0 2 0 0.09 +- 0.25 2 10

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF07730 (1/2) Histidine kinase
PF01061 (1/2) ABC-2 type transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_35886 95.67 +- 9.64 2 0 0 2 0.05 +- 0.03 2 10

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/2) Glutamine amidotransferase domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02195 (2/2) ParB-like nuclease domain
PF00733 (2/2) Asparagine synthase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_12331 215.00 +- 43.00 4 0 0 0 0.01 +- 0.00 4 4

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF02894 (4/4) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_jaccard_groups_9126 69.33 +- 46.77 2 0 0 0 0.15 +- 0.18 2 9

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
PF02803 (1/2) Thiolase, C-terminal domain
PF01925 (1/2) Sulfite exporter TauE/SafE
PF00108 (1/2) Thiolase, N-terminal domain
precursor_jaccard_groups_31899 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_9124 1192.54 +- 713.58 5 0 0 0 0.02 +- 0.02 5 6

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
precursor_jaccard_groups_42460 21.74 +- 2.70 2 0 0 0 0.14 +- 0.16 2 5

TIGR03356 (2/2) beta-galactosidase
PF08445 (2/2) FR47-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF06030 (2/2) Bacterial protein of unknown function (DUF916)
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_18219 320.43 +- 63.17 3 0 3 0 0.03 +- 0.06 3 14

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13183 (3/3) 4Fe-4S dicluster domain
PF10370 (3/3) Domain of unknown function (DUF2437)
PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01565 (3/3) FAD binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_5362 139.96 +- 73.90 8 0 0 0 0.08 +- 0.09 8 7

PF07729 (8/8) FCD domain
PF01670 (8/8) Glycosyl hydrolase family 12
PF01081 (8/8) KDPG and KHG aldolase
PF00553 (8/8) Cellulose binding domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
PF00144 (8/8) Beta-lactamase
precursor_jaccard_groups_14207 323.50 +- 63.50 2 0 0 0 0.02 +- 0.01 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_9057 456.25 +- 207.42 5 0 5 5 0.02 +- 0.01 5 16

TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
TIGR00857 (5/5) dihydroorotase, multifunctional complex type
PF13537 (5/5) Glutamine amidotransferase domain
PF04303 (5/5) PrpF protein
PF03358 (5/5) NADPH-dependent FMN reductase
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01979 (5/5) Amidohydrolase family
PF01494 (5/5) FAD binding domain
PF00733 (5/5) Asparagine synthase
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF07690 (4/5) Major Facilitator Superfamily
PF00268 (4/5) Ribonucleotide reductase, small chain
precursor_jaccard_groups_6052 142.16 +- 107.72 6 0 0 0 0.04 +- 0.08 6 3

PF10935 (6/6) Protein of unknown function (DUF2637)
PF00239 (6/6) Resolvase, N terminal domain
PF01695 (3/6) IstB-like ATP binding protein
precursor_jaccard_groups_9720 55.69 +- 1.94 2 0 0 0 0.18 +- 0.23 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13454 (2/2) FAD-NAD(P)-binding
PF02983 (2/2) Alpha-lytic protease prodomain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7509 174.02 +- 106.46 3 0 0 0 0.03 +- 0.05 3 4

PF07702 (3/3) UTRA domain
PF07690 (3/3) Major Facilitator Superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_39170 780.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF12802 (2/2) MarR family
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
precursor_jaccard_groups_7054 490.44 +- 25.62 6 0 6 6 0.01 +- 0.00 6 6

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00685 (6/6) Sulfotransferase domain
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_12826 36.88 +- 3.03 4 0 4 0 0.08 +- 0.01 4 3

PF00550 (4/4) Phosphopantetheine attachment site
PF00268 (4/4) Ribonucleotide reductase, small chain
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_12823 60.28 +- 4.67 2 0 0 0 0.13 +- 0.30 2 4

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03780 (2/2) Asp23 family, cell envelope-related function
precursor_jaccard_groups_6694 806.75 +- 193.00 2 0 1 2 0.05 +- 0.17 2 26

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13581 (2/2) Histidine kinase-like ATPase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04672 (2/2) S-adenosyl methyltransferase
PF03457 (2/2) Helicase associated domain
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01590 (2/2) GAF domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13649 (1/2) Methyltransferase domain
PF08241 (1/2) Methyltransferase domain
PF00872 (1/2) Transposase, Mutator family
precursor_jaccard_groups_44301 1290.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF13242 (2/2) HAD-hyrolase-like
PF06182 (2/2) ABC-2 family transporter protein
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_19375 68.47 +- 9.68 2 0 0 0 0.15 +- 0.14 2 14

PF04909 (2/2) Amidohydrolase
PF04199 (2/2) Putative cyclase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
TIGR02429 (1/2) 3-oxoacid CoA-transferase, A subunit
TIGR02428 (1/2) 3-oxoacid CoA-transferase, B subunit
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12802 (1/2) MarR family
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF01614 (1/2) Bacterial transcriptional regulator
PF01144 (1/2) Coenzyme A transferase
precursor_jaccard_groups_43939 256.29 +- 219.14 2 0 0 0 0.07 +- 0.13 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_35109 405.53 +- 129.77 2 0 2 0 0.03 +- 0.04 2 18

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01063 (2/2) Amino-transferase class IV
PF00850 (2/2) Histone deacetylase domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00425 (2/2) chorismate binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_jaccard_groups_10681 78.13 +- 105.07 4 0 0 0 0.09 +- 0.11 4 2

PF07702 (4/4) UTRA domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_10685 12.56 +- 0.75 5 0 0 0 0.24 +- 0.03 5 5

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF04909 (5/5) Amidohydrolase
PF01575 (5/5) MaoC like domain
PF00501 (5/5) AMP-binding enzyme
precursor_jaccard_groups_2974 33.88 +- 3.13 2 0 2 0 0.18 +- 0.28 2 11

TIGR01935 (2/2) RraA family
PF14378 (2/2) PAP2 superfamily
PF12222 (2/2) Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A
PF07730 (2/2) Histidine kinase
PF04226 (2/2) Transglycosylase associated protein
PF03737 (2/2) Aldolase/RraA
PF00494 (2/2) Squalene/phytoene synthase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_14370 41.59 +- 6.30 3 0 0 3 0.12 +- 0.23 3 15

TIGR04339 (3/3) PQQ system protein
TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR03075 (3/3) PQQ-dependent dehydrogenase, methanol/ethanol family
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
TIGR02107 (3/3) coenzyme PQQ precursor peptide PqqA
TIGR00198 (3/3) catalase/peroxidase HPI
PF13360 (3/3) PQQ-like domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08042 (3/3) PqqA family
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04397 (3/3) LytTr DNA-binding domain
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
PF00141 (3/3) Peroxidase
precursor_jaccard_groups_11403 207.33 +- 73.07 3 0 0 0 0.01 +- 0.01 3 2

PF07859 (3/3) alpha/beta hydrolase fold
PF01569 (3/3) PAP2 superfamily
precursor_jaccard_groups_8232 115.24 +- 34.84 5 0 0 0 0.07 +- 0.07 5 8

TIGR01484 (5/5) HAD hydrolase, family IIB
PF13309 (5/5) HTH domain
PF08348 (5/5) YheO-like PAS domain
PF08282 (5/5) haloacid dehalogenase-like hydrolase
PF04655 (5/5) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF04075 (5/5) F420H(2)-dependent quinone reductase
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_19270 631.53 +- 248.09 3 0 3 0 0.02 +- 0.01 3 9

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06259 (3/3) Alpha/beta hydrolase
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_1587 37.10 +- 20.46 11 0 0 0 0.11 +- 0.13 11 5

PF05331 (11/11) Protein of unknown function (DUF742)
PF04149 (11/11) Domain of unknown function (DUF397)
PF03259 (11/11) Roadblock/LC7 domain
PF03029 (11/11) Conserved hypothetical ATP binding protein
PF00067 (11/11) Cytochrome P450
precursor_jaccard_groups_6676 47.01 +- 9.00 4 0 0 0 0.20 +- 0.13 4 8

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13343 (4/4) Bacterial extracellular solute-binding protein
PF08402 (4/4) TOBE domain
PF03372 (4/4) Endonuclease/Exonuclease/phosphatase family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00005 (4/4) ABC transporter
PF07690 (2/4) Major Facilitator Superfamily
precursor_jaccard_groups_4565 49.55 +- 30.01 7 0 1 0 0.16 +- 0.26 7 13

TIGR04382 (7/7) 5-dehydro-2-deoxygluconokinase
TIGR04377 (7/7) 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00294 (7/7) pfkB family carbohydrate kinase
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
TIGR04378 (6/7) 5-deoxy-glucuronate isomerase
TIGR01722 (6/7) methylmalonate-semialdehyde dehydrogenase (acylating)
PF04962 (6/7) KduI/IolB family
PF02894 (6/7) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (6/7) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (6/7) Xylose isomerase-like TIM barrel
PF00171 (6/7) Aldehyde dehydrogenase family
precursor_jaccard_groups_18675 40.24 +- 11.36 2 0 0 0 0.06 +- 0.08 2 8

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF16656 (2/2) Purple acid Phosphatase, N-terminal domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07971 (2/2) Glycosyl hydrolase family 92
PF01638 (2/2) HxlR-like helix-turn-helix
PF00149 (2/2) Calcineurin-like phosphoesterase
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
precursor_jaccard_groups_9541 345.07 +- 214.66 5 0 5 0 0.02 +- 0.01 5 15

TIGR01733 (5/5) amino acid adenylation domain
TIGR01188 (5/5) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00838 (5/5) argininosuccinate lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF11495 (5/5) Archaeal transcriptional regulator TrmB
PF03767 (5/5) HAD superfamily, subfamily IIIB (Acid phosphatase)
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_41895 256.55 +- 33.70 2 0 0 0 0.02 +- 0.03 2 6

TIGR00212 (2/2) hydroxymethylbilane synthase
PF03900 (2/2) Porphobilinogen deaminase, C-terminal domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01379 (2/2) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_2585 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF03640 (2/2) Secreted repeat of unknown function
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
precursor_jaccard_groups_6785 48.68 +- 11.86 4 0 0 0 0.04 +- 0.06 4 5

TIGR00641 (4/4) methylmalonyl-CoA mutase N-terminal domain
PF03308 (4/4) Methylmalonyl Co-A mutase-associated GTPase MeaB
PF02310 (4/4) B12 binding domain
PF01642 (4/4) Methylmalonyl-CoA mutase
PF00353 (4/4) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_jaccard_groups_1478 44.57 +- 18.71 8 0 0 0 0.18 +- 0.19 8 8

TIGR03718 (8/8) integral membrane protein, TerC family
PF05331 (8/8) Protein of unknown function (DUF742)
PF03741 (8/8) Integral membrane protein TerC family
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF00378 (7/8) Enoyl-CoA hydratase/isomerase
PF00067 (7/8) Cytochrome P450
PF18029 (4/8) Glyoxalase-like domain
precursor_jaccard_groups_36314 127.51 +- 3.67 2 0 2 0 0.08 +- 0.17 2 11

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_19678 201.34 +- 185.66 2 0 0 0 0.10 +- 0.12 2 3

PF05425 (2/2) Copper resistance protein D
PF02515 (2/2) CoA-transferase family III
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_14684 71.52 +- 10.65 4 0 4 4 0.06 +- 0.04 4 5

PF13471 (4/4) Transglutaminase-like superfamily
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (4/4) Asparagine synthase
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_6588 25.34 +- 6.76 6 0 0 0 0.16 +- 0.12 6 18

TIGR03346 (6/6) ATP-dependent chaperone protein ClpB
TIGR02350 (6/6) chaperone protein DnaK
PF17871 (6/6) AAA lid domain
PF10431 (6/6) C-terminal, D2-small domain, of ClpB protein
PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (6/6) AAA domain (Cdc48 subfamily)
PF02861 (6/6) Clp amino terminal domain, pathogenicity island component
PF02148 (6/6) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (6/6) DnaJ C terminal domain
PF01025 (6/6) GrpE
PF00226 (6/6) DnaJ domain
PF00085 (6/6) Thioredoxin
PF00027 (6/6) Cyclic nucleotide-binding domain
PF00012 (6/6) Hsp70 protein
PF00004 (6/6) ATPase family associated with various cellular activities (AAA)
TIGR01068 (5/6) thioredoxin
PF13591 (5/6) MerR HTH family regulatory protein
PF00011 (5/6) Hsp20/alpha crystallin family
precursor_jaccard_groups_23039 372.43 +- 218.12 3 0 3 3 0.07 +- 0.17 3 4

TIGR03558 (3/3) luciferase family oxidoreductase, group 1
PF07690 (3/3) Major Facilitator Superfamily
PF05147 (3/3) Lanthionine synthetase C-like protein
PF00296 (3/3) Luciferase-like monooxygenase
precursor_jaccard_groups_41940 347.93 +- 153.74 2 0 2 2 0.05 +- 0.08 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6781 199.97 +- 52.36 6 0 6 0 0.12 +- 0.17 6 19

TIGR01181 (6/6) dTDP-glucose 4,6-dehydratase
PF16363 (6/6) GDP-mannose 4,6 dehydratase
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF10604 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF07690 (6/6) Major Facilitator Superfamily
PF04672 (6/6) S-adenosyl methyltransferase
PF03559 (6/6) NDP-hexose 2,3-dehydratase
PF03358 (6/6) NADPH-dependent FMN reductase
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF01757 (6/6) Acyltransferase family
PF01494 (6/6) FAD binding domain
PF01408 (6/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF01041 (6/6) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (6/6) Phosphopantetheine attachment site
PF00248 (6/6) Aldo/keto reductase family
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00106 (6/6) short chain dehydrogenase
PF04673 (5/6) Polyketide synthesis cyclase
precursor_jaccard_groups_19675 518.00 +- 181.02 3 0 3 0 0.01 +- 0.00 3 3

PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01613 (3/3) Flavin reductase like domain
precursor_jaccard_groups_817 44.13 +- 25.70 2 0 0 0 0.19 +- 0.38 2 10

TIGR00225 (2/2) C-terminal processing peptidase
TIGR00086 (2/2) SsrA-binding protein
PF17820 (2/2) PDZ domain
PF14016 (2/2) Protein of unknown function (DUF4232)
PF03572 (2/2) Peptidase family S41
PF01668 (2/2) SmpB protein
TIGR01840 (1/2) esterase, PHB depolymerase family
TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF10503 (1/2) Esterase PHB depolymerase
PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_jaccard_groups_33545 40.66 +- 1.66 2 0 2 0 0.15 +- 0.31 2 9

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_33541 81.71 +- 56.95 2 0 0 0 0.10 +- 0.11 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF11239 (2/2) Protein of unknown function (DUF3040)
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_1299 47.56 +- 24.22 16 0 0 0 0.10 +- 0.10 16 4

TIGR03860 (16/16) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (16/16) Major Facilitator Superfamily
PF00296 (16/16) Luciferase-like monooxygenase
PF00106 (14/16) short chain dehydrogenase
precursor_jaccard_groups_22033 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_jaccard_groups_19416 34.27 +- 8.13 3 0 3 3 0.18 +- 0.25 3 10

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01207 (3/3) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/3) dTDP-glucose 4,6-dehydratase
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF07730 (3/3) Histidine kinase
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00483 (3/3) Nucleotidyl transferase
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
precursor_jaccard_groups_41098 49.36 +- 5.66 2 0 0 0 0.21 +- 0.13 2 8

PF13560 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF04149 (2/2) Domain of unknown function (DUF397)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_8525 35.67 +- 3.42 2 0 0 0 0.17 +- 0.28 2 3

PF13649 (2/2) Methyltransferase domain
PF04978 (2/2) Protein of unknown function (DUF664)
PF04149 (2/2) Domain of unknown function (DUF397)
precursor_jaccard_groups_37004 87.37 +- 4.65 2 0 0 0 0.10 +- 0.11 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10091 (2/2) Putative glucoamylase
PF04149 (2/2) Domain of unknown function (DUF397)
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_27048 220.60 +- 101.90 2 0 0 0 0.02 +- 0.02 2 6

PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00857 (2/2) Isochorismatase family
PF08448 (1/2) PAS fold
PF00582 (1/2) Universal stress protein family
precursor_jaccard_groups_1611 26.64 +- 9.38 23 0 2 0 0.14 +- 0.06 23 4

TIGR03328 (23/23) methylthioribulose-1-phosphate dehydratase
TIGR01691 (23/23) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (23/23) ARD/ARD' family
PF00596 (23/23) Class II Aldolase and Adducin N-terminal domain
precursor_jaccard_groups_27461 28.92 +- 7.25 2 0 0 0 0.15 +- 0.23 2 8

TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14404 (2/2) Ribosomally synthesized peptide in Streptomyces species
PF13449 (2/2) Esterase-like activity of phytase
PF12796 (2/2) Ankyrin repeats (3 copies)
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_10268 56.94 +- 36.88 2 0 0 0 0.15 +- 0.28 2 8

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13459 (2/2) 4Fe-4S single cluster domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF07681 (1/2) DoxX
precursor_jaccard_groups_6475 25.88 +- 9.37 6 0 0 0 0.09 +- 0.11 6 5

PF17866 (6/6) AAA lid domain
PF13229 (6/6) Right handed beta helix region
PF00652 (6/6) Ricin-type beta-trefoil lectin domain
PF00082 (6/6) Subtilase family
PF00004 (6/6) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_20897 33.73 +- 10.19 3 0 0 0 0.10 +- 0.15 3 4

TIGR01701 (3/3) oxidoreductase alpha (molybdopterin) subunit
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_jaccard_groups_35869 23.32 +- 3.77 2 0 0 0 0.18 +- 0.13 2 7

TIGR01048 (2/2) diaminopimelate decarboxylase
TIGR00247 (2/2) conserved hypothetical protein, YceG family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02618 (2/2) YceG-like family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_39741 116.12 +- 4.23 2 0 1 0 0.15 +- 0.28 2 26

TIGR03221 (2/2) muconolactone delta-isomerase
TIGR02438 (2/2) catechol 1,2-dioxygenase
PF13577 (2/2) SnoaL-like domain
PF13532 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13378 (2/2) Enolase C-terminal domain-like
PF12891 (2/2) Glycoside hydrolase family 44
PF09339 (2/2) IclR helix-turn-helix domain
PF07745 (2/2) Glycosyl hydrolase family 53
PF07690 (2/2) Major Facilitator Superfamily
PF04444 (2/2) Catechol dioxygenase N terminus
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02426 (2/2) Muconolactone delta-isomerase
PF01614 (2/2) Bacterial transcriptional regulator
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00866 (2/2) Ring hydroxylating beta subunit
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00775 (2/2) Dioxygenase
PF00553 (2/2) Cellulose binding domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (2/2) short chain dehydrogenase
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_35861 893.37 +- 424.28 2 0 2 0 0.01 +- 0.02 2 24

TIGR01733 (2/2) amino acid adenylation domain
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12802 (2/2) MarR family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01613 (2/2) Flavin reductase like domain
PF01474 (2/2) Class-II DAHP synthetase family
PF00975 (2/2) Thioesterase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_39953 1013.89 +- 362.11 2 0 0 0 0.01 +- 0.01 2 9

PF13483 (2/2) Beta-lactamase superfamily domain
PF09084 (2/2) NMT1/THI5 like
PF03972 (2/2) MmgE/PrpD family
PF03466 (2/2) LysR substrate binding domain
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF01361 (2/2) Tautomerase enzyme
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_37710 322.50 +- 223.27 2 0 2 0 0.06 +- 0.21 2 18

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01035 (2/2) glutamyl-tRNA reductase
PF17645 (2/2) Arylmalonate decarboxylase
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13549 (2/2) ATP-grasp domain
PF13380 (2/2) CoA binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF05201 (2/2) Glutamyl-tRNAGlu reductase, N-terminal domain
PF03795 (2/2) YCII-related domain
PF03466 (2/2) LysR substrate binding domain
PF01494 (2/2) FAD binding domain
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00892 (2/2) EamA-like transporter family
PF00745 (2/2) Glutamyl-tRNAGlu reductase, dimerisation domain
PF00490 (2/2) Delta-aminolevulinic acid dehydratase
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_39951 32.14 +- 5.91 2 0 0 0 0.10 +- 0.16 2 6

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF05977 (2/2) Transmembrane secretion effector
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_8416 156.60 +- 58.07 6 0 0 0 0.08 +- 0.13 6 7

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF07045 (6/6) Domain of unknown function (DUF1330)
PF01738 (6/6) Dienelactone hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_13801 1460.18 +- 638.65 4 0 0 0 0.01 +- 0.01 4 9

TIGR03850 (4/4) carbohydrate ABC transporter substrate-binding protein, CPR_0540 family
PF13377 (4/4) Periplasmic binding protein-like domain
PF01120 (4/4) Alpha-L-fucosidase
PF00754 (4/4) F5/8 type C domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF13416 (2/4) Bacterial extracellular solute-binding protein
PF13145 (2/4) PPIC-type PPIASE domain
PF01547 (2/4) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_5559 50.00 +- 13.87 8 0 0 0 0.13 +- 0.09 8 5

PF07729 (8/8) FCD domain
PF03067 (8/8) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (8/8) Glycosyl hydrolase family 12
PF00553 (8/8) Cellulose binding domain
PF00392 (8/8) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_21453 140.60 +- 64.81 3 0 0 0 0.03 +- 0.04 3 5

PF13564 (3/3) DoxX-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (3/3) NADPH-dependent FMN reductase
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_22638 2762.67 +- 988.06 3 0 3 0 0.01 +- 0.00 3 13

TIGR03297 (3/3) phosphonopyruvate decarboxylase
TIGR00045 (3/3) glycerate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF02595 (3/3) Glycerate kinase family
PF01061 (3/3) ABC-2 type transporter
PF00696 (3/3) Amino acid kinase family
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00266 (3/3) Aminotransferase class-V
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_30446 34.53 +- 5.50 2 0 2 0 0.09 +- 0.10 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_18266 64.76 +- 3.28 2 0 1 0 0.23 +- 0.22 2 18

TIGR00839 (2/2) aspartate ammonia-lyase
PF10415 (2/2) Fumarase C C-terminus
PF07729 (2/2) FCD domain
PF06089 (2/2) L-asparaginase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF00206 (2/2) Lyase
PF18631 (1/2) Cucumopine synthase C-terminal helical bundle domain
PF17203 (1/2) Single cache domain 3
PF14689 (1/2) Sensor_kinase_SpoOB-type, alpha-helical domain
PF09339 (1/2) IclR helix-turn-helix domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01266 (1/2) FAD dependent oxidoreductase
PF00989 (1/2) PAS fold
PF00501 (1/2) AMP-binding enzyme
PF00171 (1/2) Aldehyde dehydrogenase family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_22633 452.02 +- 56.64 3 0 0 0 0.02 +- 0.01 3 5

PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF01935 (3/3) Helicase HerA, central domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_jaccard_groups_12535 128.33 +- 106.21 4 0 4 0 0.05 +- 0.02 4 12

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
PF18130 (4/4) ATP-grasp N-terminal domain
PF13640 (4/4) 2OG-Fe(II) oxygenase superfamily
PF13535 (4/4) ATP-grasp domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00106 (4/4) short chain dehydrogenase
precursor_jaccard_groups_13935 43.48 +- 6.72 3 0 3 0 0.09 +- 0.15 3 8

TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR02353 (3/3) non-ribosomal peptide synthetase terminal domain of unknown function
TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_11220 148.57 +- 74.71 4 0 0 0 0.02 +- 0.04 4 6

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03919 (4/4) type VII secretion protein EccB
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (3/4) type VII secretion integral membrane protein EccD
PF08817 (3/4) WXG100 protein secretion system (Wss), protein YukD
precursor_jaccard_groups_27681 146.45 +- 50.79 2 0 0 0 0.11 +- 0.03 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (2/2) FMN reductase
PF09084 (2/2) NMT1/THI5 like
PF03358 (2/2) NADPH-dependent FMN reductase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1056 67.02 +- 20.38 31 0 0 0 0.11 +- 0.06 31 14

PF13561 (31/31) Enoyl-(Acyl carrier protein) reductase
PF12697 (31/31) Alpha/beta hydrolase family
PF07883 (31/31) Cupin domain
PF03447 (31/31) Homoserine dehydrogenase, NAD binding domain
PF02776 (31/31) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (31/31) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01958 (31/31) Domain of unknown function DUF108
PF01042 (31/31) Endoribonuclease L-PSP
PF00903 (31/31) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00355 (31/31) Rieske [2Fe-2S] domain
PF00205 (31/31) Thiamine pyrophosphate enzyme, central domain
PF00175 (31/31) Oxidoreductase NAD-binding domain
PF00171 (31/31) Aldehyde dehydrogenase family
PF00111 (31/31) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_28863 29.88 +- 1.21 2 0 0 0 0.13 +- 0.16 2 3

TIGR01755 (2/2) NAD(P)H:quinone oxidoreductase, type IV
PF08445 (2/2) FR47-like protein
PF03358 (2/2) NADPH-dependent FMN reductase
precursor_jaccard_groups_1053 9.45 +- 0.70 5 0 2 0 0.21 +- 0.13 5 4

PF02133 (5/5) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01070 (5/5) FMN-dependent dehydrogenase
PF02826 (4/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF12697 (3/5) Alpha/beta hydrolase family
precursor_jaccard_groups_26027 85.92 +- 7.41 2 0 2 2 0.16 +- 0.11 2 11

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_37822 148.57 +- 0.00 2 0 2 2 0.01 +- 0.01 2 5

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00733 (2/2) Asparagine synthase
PF00221 (2/2) Aromatic amino acid lyase
precursor_jaccard_groups_34842 271.23 +- 244.77 2 0 0 0 0.03 +- 0.07 2 9

PF13560 (2/2) Helix-turn-helix domain
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF07745 (2/2) Glycosyl hydrolase family 53
PF04149 (2/2) Domain of unknown function (DUF397)
PF02449 (2/2) Beta-galactosidase
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00069 (1/2) Protein kinase domain
precursor_jaccard_groups_9943 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_27995 20.95 +- 1.83 2 0 0 0 0.19 +- 0.38 2 8

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
TIGR01341 (2/2) aconitate hydratase 1
PF00704 (2/2) Glycosyl hydrolases family 18
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)
TIGR03851 (1/2) carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_29595 18.30 +- 0.96 2 0 0 0 0.19 +- 0.05 2 12

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13478 (2/2) XdhC Rossmann domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_jaccard_groups_5612 53.79 +- 13.26 5 0 5 0 0.18 +- 0.19 5 24

TIGR00073 (5/5) hydrogenase accessory protein HypB
TIGR00072 (5/5) hydrogenase maturation protease
PF14720 (5/5) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (5/5) Protein of unknown function (DUF4232)
PF07503 (5/5) HypF finger
PF02492 (5/5) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (5/5) Hydrogenase maturation protease
PF01300 (5/5) Telomere recombination
PF01155 (5/5) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (5/5) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (5/5) Acylphosphatase
PF00374 (5/5) Nickel-dependent hydrogenase
TIGR00143 (4/5) carbamoyltransferase HypF
PF17788 (4/5) HypF Kae1-like domain
TIGR02124 (3/5) hydrogenase expression/formation protein HypE
TIGR00075 (3/5) hydrogenase expression/formation protein HypD
TIGR00074 (3/5) hydrogenase assembly chaperone HypC/HupF
PF12833 (3/5) Helix-turn-helix domain
PF12625 (3/5) Arabinose-binding domain of AraC transcription regulator, N-term
PF03583 (3/5) Secretory lipase
PF02769 (3/5) AIR synthase related protein, C-terminal domain
PF01924 (3/5) Hydrogenase formation hypA family
PF01455 (3/5) HupF/HypC family
PF00586 (3/5) AIR synthase related protein, N-terminal domain
precursor_jaccard_groups_19895 498.13 +- 195.19 3 0 0 0 0.01 +- 0.02 3 13

TIGR02348 (3/3) chaperonin GroL
TIGR01197 (3/3) metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF04909 (3/3) Amidohydrolase
PF02406 (3/3) MmoB/DmpM family
PF02332 (3/3) Methane/Phenol/Toluene Hydroxylase
PF01883 (3/3) Iron-sulfur cluster assembly protein
PF01566 (3/3) Natural resistance-associated macrophage protein
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00118 (3/3) TCP-1/cpn60 chaperonin family
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_21211 200.11 +- 58.80 3 0 0 0 0.04 +- 0.03 3 12

TIGR01167 (3/3) LPXTG cell wall anchor domain
PF18130 (3/3) ATP-grasp N-terminal domain
PF17802 (3/3) Prealbumin-like fold domain
PF16259 (3/3) Domain of unknown function (DUF4913)
PF13535 (3/3) ATP-grasp domain
PF12307 (3/3) Protein of unknown function (DUF3631)
PF08239 (3/3) Bacterial SH3 domain
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF02899 (3/3) Phage integrase, N-terminal SAM-like domain
PF01638 (3/3) HxlR-like helix-turn-helix
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_jaccard_groups_19897 32.68 +- 0.44 3 0 0 0 0.12 +- 0.14 3 4

PF13701 (3/3) Transposase DDE domain group 1
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01476 (3/3) LysM domain
PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_21213 72.50 +- 7.50 2 0 0 0 0.03 +- 0.03 2 4

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF12840 (2/2) Helix-turn-helix domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_5577 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_jaccard_groups_21218 75.58 +- 11.08 2 0 0 0 0.03 +- 0.02 2 7

TIGR00348 (2/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF11867 (2/2) Domain of unknown function (DUF3387)
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_jaccard_groups_22253 76.16 +- 29.36 3 0 3 0 0.07 +- 0.12 3 5

PF03777 (3/3) ChpA-C
PF03559 (3/3) NDP-hexose 2,3-dehydratase
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (3/3) dTDP-4-dehydrorhamnose 3,5-epimerase
precursor_jaccard_groups_10912 148.63 +- 64.84 5 0 0 0 0.12 +- 0.19 5 11

PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF05544 (5/5) Proline racemase
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF00005 (5/5) ABC transporter
PF13510 (4/5) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/5) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (4/5) BFD-like [2Fe-2S] binding domain
PF01266 (4/5) FAD dependent oxidoreductase
PF00701 (4/5) Dihydrodipicolinate synthetase family
precursor_jaccard_groups_10911 389.37 +- 400.51 5 0 0 0 0.10 +- 0.17 5 8

PF13411 (5/5) MerR HTH family regulatory protein
PF07739 (5/5) TipAS antibiotic-recognition domain
PF03033 (5/5) Glycosyltransferase family 28 N-terminal domain
PF01551 (5/5) Peptidase family M23
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00005 (5/5) ABC transporter
PF12679 (4/5) ABC-2 family transporter protein
PF00201 (3/5) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_17635 36.03 +- 2.32 3 0 3 0 0.14 +- 0.25 3 6

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04030 (3/3) D-arabinono-1,4-lactone oxidase
PF01565 (3/3) FAD binding domain
PF01522 (3/3) Polysaccharide deacetylase
PF00248 (3/3) Aldo/keto reductase family
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_30623 132.74 +- 40.60 2 0 2 0 0.04 +- 0.05 2 8

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (2/2) benzoate transporter
PF13454 (2/2) FAD-NAD(P)-binding
PF03594 (2/2) Benzoate membrane transport protein
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_25220 56.96 +- 8.04 2 0 0 0 0.22 +- 0.22 2 11

TIGR00797 (2/2) MATE efflux family protein
PF13407 (2/2) Periplasmic binding protein domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
PF00156 (1/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_13613 79.06 +- 52.46 4 0 4 0 0.17 +- 0.25 4 19

PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF14016 (4/4) Protein of unknown function (DUF4232)
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08659 (4/4) KR domain
PF08223 (4/4) PaaX-like protein C-terminal domain
PF07848 (4/4) PaaX-like protein
PF07690 (4/4) Major Facilitator Superfamily
PF04820 (4/4) Tryptophan halogenase
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13203 (2/4) Putative metallopeptidase domain
PF09967 (2/4) VWA-like domain (DUF2201)
PF07728 (2/4) AAA domain (dynein-related subfamily)
PF00534 (2/4) Glycosyl transferases group 1
precursor_jaccard_groups_29687 6286.90 +- 4033.10 2 0 2 2 0.02 +- 0.07 2 21

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12698 (2/2) ABC-2 family transporter protein
PF08044 (2/2) Domain of unknown function (DUF1707)
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_5776 795.64 +- 536.08 8 0 8 8 0.03 +- 0.08 8 12

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_jaccard_groups_37620 46.14 +- 9.40 2 0 0 0 0.18 +- 0.21 2 17

TIGR00476 (2/2) selenide, water dikinase
TIGR00474 (2/2) L-seryl-tRNA(Sec) selenium transferase
PF13247 (2/2) 4Fe-4S dicluster domain
PF12838 (2/2) 4Fe-4S dicluster domain
PF12390 (2/2) Selenocysteine synthase N terminal
PF09107 (2/2) Elongation factor SelB, winged helix
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03916 (2/2) Polysulphide reductase, NrfD
PF03841 (2/2) L-seryl-tRNA selenium transferase
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00384 (2/2) Molybdopterin oxidoreductase
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF00005 (2/2) ABC transporter
TIGR00475 (1/2) selenocysteine-specific translation elongation factor
precursor_jaccard_groups_5772 10.01 +- 0.86 8 0 8 0 0.20 +- 0.04 8 4

TIGR00055 (8/8) di-trans,poly-cis-decaprenylcistransferase
PF13202 (8/8) EF hand
PF09995 (8/8) Uncharacterized protein conserved in bacteria (DUF2236)
PF01255 (8/8) Putative undecaprenyl diphosphate synthase
precursor_jaccard_groups_31693 10.87 +- 0.95 2 0 0 0 0.19 +- 0.05 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_5809 217.25 +- 54.68 8 0 0 0 0.01 +- 0.00 8 3

PF02771 (8/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02597 (8/8) ThiS family
PF00441 (8/8) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_38557 65.25 +- 4.08 2 0 2 0 0.06 +- 0.01 2 3

TIGR04538 (2/2) cytochrome P450, cyclodipeptide synthase-associated
PF00857 (2/2) Isochorismatase family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_7987 405.84 +- 161.12 6 0 1 6 0.01 +- 0.03 6 7

TIGR00702 (6/6) YcaO-type kinase domain
PF13489 (6/6) Methyltransferase domain
PF07812 (6/6) TfuA-like protein
PF07690 (6/6) Major Facilitator Superfamily
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF18029 (5/6) Glyoxalase-like domain
PF13231 (5/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
precursor_jaccard_groups_25912 124.09 +- 5.91 2 0 0 0 0.02 +- 0.01 2 2

PF08808 (2/2) RES domain
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_4357 21.67 +- 6.75 9 0 9 0 0.17 +- 0.05 9 3

PF17851 (9/9) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (9/9) Glycosyl hydrolases family 43
PF00106 (9/9) short chain dehydrogenase
precursor_jaccard_groups_41582 190.65 +- 2.85 2 0 2 0 0.05 +- 0.03 2 11

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF07993 (2/2) Male sterility protein
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01979 (2/2) Amidohydrolase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01040 (2/2) UbiA prenyltransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase
precursor_jaccard_groups_20276 344.00 +- 121.62 3 0 0 0 0.01 +- 0.00 3 5

PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF07690 (3/3) Major Facilitator Superfamily
PF03781 (3/3) Sulfatase-modifying factor enzyme 1
PF03551 (3/3) Transcriptional regulator PadR-like family
PF00884 (3/3) Sulfatase
precursor_jaccard_groups_20271 20.19 +- 4.93 3 0 0 0 0.17 +- 0.34 3 8

TIGR00762 (3/3) EDD domain protein, DegV family
TIGR00360 (3/3) ComEC/Rec2-related protein
PF12840 (3/3) Helix-turn-helix domain
PF07690 (3/3) Major Facilitator Superfamily
PF03772 (3/3) Competence protein
PF02645 (3/3) Uncharacterised protein, DegV family COG1307
PF00797 (3/3) N-acetyltransferase
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_4352 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_16300 9.68 +- 0.13 2 0 0 0 0.21 +- 0.00 2 5

TIGR03802 (2/2) aspartate-alanine antiporter
TIGR03801 (2/2) aspartate 4-decarboxylase
PF06826 (2/2) Predicted Permease Membrane Region
PF02080 (2/2) TrkA-C domain
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_3183 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_26806 227.25 +- 162.75 2 0 0 0 0.03 +- 0.05 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_6905 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
precursor_jaccard_groups_30718 38.59 +- 7.63 2 0 0 0 0.08 +- 0.05 2 5

TIGR00638 (2/2) molybdenum-pterin binding domain
PF03459 (2/2) TOBE domain
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF12802 (1/2) MarR family
PF00480 (1/2) ROK family
precursor_jaccard_groups_14136 906.50 +- 3.50 4 0 4 4 0.01 +- 0.00 4 11

TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
TIGR00027 (4/4) methyltransferase, TIGR00027 family
PF13537 (4/4) Glutamine amidotransferase domain
PF12146 (4/4) Serine aminopeptidase, S33
PF11066 (4/4) Protein of unknown function (DUF2867)
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07366 (4/4) SnoaL-like polyketide cyclase
PF04072 (4/4) Leucine carboxyl methyltransferase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF00733 (4/4) Asparagine synthase
PF00155 (4/4) Aminotransferase class I and II
precursor_jaccard_groups_35210 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_17123 68.11 +- 7.93 3 0 3 0 0.19 +- 0.30 3 20

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (3/3) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (3/3) amino acid adenylation domain
TIGR01327 (3/3) phosphoglycerate dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF05977 (3/3) Transmembrane secretion effector
PF04073 (3/3) Aminoacyl-tRNA editing domain
PF03176 (3/3) MMPL family
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01022 (3/3) Bacterial regulatory protein, arsR family
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (3/3) Beta-lactamase
precursor_jaccard_groups_42890 1202.14 +- 87.86 2 0 2 0 0.01 +- 0.00 2 8

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7330 329.78 +- 46.39 6 0 6 0 0.02 +- 0.02 6 12

TIGR01458 (6/6) HAD hydrolase, TIGR01458 family
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF13535 (6/6) ATP-grasp domain
PF13344 (6/6) Haloacid dehalogenase-like hydrolase
PF13242 (6/6) HAD-hyrolase-like
PF07690 (6/6) Major Facilitator Superfamily
PF03364 (6/6) Polyketide cyclase / dehydrase and lipid transport
PF01663 (6/6) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01326 (6/6) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00391 (6/6) PEP-utilising enzyme, mobile domain
PF00149 (6/6) Calcineurin-like phosphoesterase
precursor_jaccard_groups_20675 89.38 +- 40.62 2 0 0 0 0.03 +- 0.01 2 4

PF13466 (2/2) STAS domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02607 (2/2) B12 binding domain
PF02310 (2/2) B12 binding domain
precursor_jaccard_groups_15967 25.95 +- 12.19 3 0 0 0 0.12 +- 0.07 3 3

PF01266 (3/3) FAD dependent oxidoreductase
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_jaccard_groups_15961 62.90 +- 17.85 3 0 1 0 0.18 +- 0.18 3 8

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (3/3) virulence factor Mce family protein
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_13187 24.49 +- 4.96 4 0 0 0 0.08 +- 0.06 4 2

PF08445 (4/4) FR47-like protein
PF01810 (4/4) LysE type translocator
precursor_jaccard_groups_28403 8.15 +- 0.00 2 0 0 0 0.25 +- 0.29 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF02018 (2/2) Carbohydrate binding domain
PF00704 (2/2) Glycosyl hydrolases family 18
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_5976 29.28 +- 15.54 4 0 0 0 0.11 +- 0.09 4 5

PF13361 (4/4) UvrD-like helicase C-terminal domain
PF13245 (4/4) AAA domain
PF04264 (4/4) YceI-like domain
PF00069 (4/4) Protein kinase domain
PF13546 (2/4) DDE superfamily endonuclease
precursor_jaccard_groups_37530 329.72 +- 50.99 2 0 0 0 0.03 +- 0.05 2 11

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13229 (2/2) Right handed beta helix region
PF07745 (2/2) Glycosyl hydrolase family 53
PF07532 (2/2) Bacterial Ig-like domain (group 4)
PF04616 (2/2) Glycosyl hydrolases family 43
PF03583 (2/2) Secretory lipase
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01522 (2/2) Polysaccharide deacetylase
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_518 347.40 +- 281.52 57 0 0 0 0.04 +- 0.02 57 11

TIGR01733 (57/57) amino acid adenylation domain
PF11695 (57/57) Domain of unknown function (DUF3291)
PF09334 (57/57) tRNA synthetases class I (M)
PF07883 (57/57) Cupin domain
PF07859 (57/57) alpha/beta hydrolase fold
PF01494 (57/57) FAD binding domain
PF00583 (57/57) Acetyltransferase (GNAT) family
PF00581 (57/57) Rhodanese-like domain
PF00501 (57/57) AMP-binding enzyme
PF01266 (55/57) FAD dependent oxidoreductase
PF13434 (54/57) L-lysine 6-monooxygenase (NADPH-requiring)
precursor_jaccard_groups_17019 160.60 +- 97.40 2 0 0 0 0.10 +- 0.28 2 4

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_38142 47.20 +- 0.00 2 0 0 0 0.06 +- 0.07 2 7

TIGR00229 (2/2) PAS domain S-box protein
PF14342 (2/2) Domain of unknown function (DUF4396)
PF13426 (2/2) PAS domain
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00857 (2/2) Isochorismatase family
precursor_jaccard_groups_25178 48.24 +- 18.38 2 0 0 0 0.16 +- 0.08 2 8

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13692 (2/2) Glycosyl transferases group 1
PF12138 (2/2) Spherulation-specific family 4
PF11997 (2/2) Domain of unknown function (DUF3492)
PF03537 (2/2) Glycoside-hydrolase family GH114
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00483 (2/2) Nucleotidyl transferase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40617 136.72 +- 7.72 2 0 0 0 0.01 +- 0.01 2 3

PF09362 (2/2) Domain of unknown function (DUF1996)
PF08924 (2/2) Domain of unknown function (DUF1906)
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_25689 41.78 +- 18.92 2 0 0 0 0.12 +- 0.09 2 5

TIGR00504 (2/2) pyroglutamyl-peptidase I
PF11199 (2/2) Protein of unknown function (DUF2891)
PF06166 (2/2) Protein of unknown function (DUF979)
PF06149 (2/2) Protein of unknown function (DUF969)
PF01470 (2/2) Pyroglutamyl peptidase
precursor_jaccard_groups_10863 68.65 +- 72.99 5 0 0 0 0.08 +- 0.09 5 4

PF14200 (5/5) Ricin-type beta-trefoil lectin domain-like
PF09997 (5/5) Predicted membrane protein (DUF2238)
PF05270 (5/5) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (5/5) Glycosyl hydrolases family 43
precursor_jaccard_groups_24953 511.00 +- 91.00 2 0 0 0 0.01 +- 0.01 2 8

TIGR01722 (2/2) methylmalonate-semialdehyde dehydrogenase (acylating)
PF11534 (2/2) Hexameric tyrosine-coordinated heme protein (HTHP)
PF07690 (2/2) Major Facilitator Superfamily
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_40348 366.73 +- 1.84 2 0 0 0 0.03 +- 0.02 2 12

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF05977 (2/2) Transmembrane secretion effector
PF05199 (2/2) GMC oxidoreductase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF14013 (1/2) MT0933-like antitoxin protein
PF03707 (1/2) Bacterial signalling protein N terminal repeat
PF00135 (1/2) Carboxylesterase family
precursor_jaccard_groups_32955 35.83 +- 7.17 2 0 0 0 0.06 +- 0.05 2 3

PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_15897 24.51 +- 9.58 3 0 0 0 0.10 +- 0.06 3 4

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07398 (3/3) MDMPI C-terminal domain
PF01814 (3/3) Hemerythrin HHE cation binding domain
precursor_jaccard_groups_42252 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_jaccard_groups_45649 580.50 +- 0.00 2 0 0 0 0.02 +- 0.00 2 4

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04909 (2/2) Amidohydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_16546 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
precursor_jaccard_groups_44261 70.56 +- 11.54 2 0 0 0 0.15 +- 0.14 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF02342 (2/2) TerD domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_40900 23.09 +- 9.24 2 0 0 0 0.20 +- 0.15 2 8

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF18029 (2/2) Glyoxalase-like domain
PF16116 (2/2) Domain of unknown function (DUF4832)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04476 (2/2) 4-HFC-P synthase
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_24310 55.00 +- 9.04 2 0 0 0 0.20 +- 0.24 2 9

PF12708 (2/2) Pectate lyase superfamily protein
PF07705 (2/2) CARDB
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF11941 (1/2) Domain of unknown function (DUF3459)
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_19527 62.67 +- 21.49 3 0 0 0 0.09 +- 0.12 3 6

PF13378 (3/3) Enolase C-terminal domain-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_21848 2338.97 +- 241.03 2 0 0 0 0.01 +- 0.02 2 10

PF12680 (2/2) SnoaL-like domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00005 (2/2) ABC transporter
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF01494 (1/2) FAD binding domain
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_41615 65.11 +- 20.89 2 0 2 0 0.13 +- 0.24 2 9

PF18029 (2/2) Glyoxalase-like domain
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05401 (2/2) Nodulation protein S (NodS)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00107 (2/2) Zinc-binding dehydrogenase
PF01276 (1/2) Orn/Lys/Arg decarboxylase, major domain
precursor_jaccard_groups_13327 139.95 +- 120.14 4 0 0 0 0.08 +- 0.12 4 3

PF02782 (4/4) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (4/4) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (4/4) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_34925 38.25 +- 3.59 2 0 0 0 0.11 +- 0.18 2 5

PF11239 (2/2) Protein of unknown function (DUF3040)
PF07690 (2/2) Major Facilitator Superfamily
PF04203 (2/2) Sortase domain
PF02610 (2/2) L-arabinose isomerase
PF00999 (2/2) Sodium/hydrogen exchanger family
precursor_jaccard_groups_31153 380.73 +- 115.42 2 0 0 2 0.03 +- 0.03 2 8

PF14099 (2/2) Polysaccharide lyase
PF13377 (2/2) Periplasmic binding protein-like domain
PF13360 (2/2) PQQ-like domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF06283 (1/2) Trehalose utilisation
precursor_jaccard_groups_28138 135.10 +- 124.90 2 0 0 0 0.10 +- 0.16 2 1

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_34923 180.30 +- 87.44 2 0 0 0 0.07 +- 0.14 2 12

PF07730 (2/2) Histidine kinase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF03008 (2/2) Archaea bacterial proteins of unknown function
PF02687 (2/2) FtsX-like permease family
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF13424 (1/2) Tetratricopeptide repeat
PF13176 (1/2) Tetratricopeptide repeat
PF00931 (1/2) NB-ARC domain
precursor_jaccard_groups_34381 62.24 +- 15.92 2 0 0 0 0.12 +- 0.17 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3291 435.68 +- 245.53 11 0 10 0 0.01 +- 0.01 11 4

PF04324 (11/11) BFD-like [2Fe-2S] binding domain
PF00551 (11/11) Formyl transferase
PF00334 (11/11) Nucleoside diphosphate kinase
PF00202 (11/11) Aminotransferase class-III
precursor_jaccard_groups_40584 54.16 +- 11.43 2 0 0 0 0.15 +- 0.23 2 10

PF18029 (2/2) Glyoxalase-like domain
PF13191 (2/2) AAA ATPase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00210 (2/2) Ferritin-like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_44606 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF06912 (2/2) Protein of unknown function (DUF1275)
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_3188 424.27 +- 220.30 11 0 7 0 0.06 +- 0.03 11 18

PF13561 (11/11) Enoyl-(Acyl carrier protein) reductase
PF08545 (11/11) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (11/11) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (11/11) Beta-ketoacyl synthase, C-terminal domain
PF01144 (11/11) Coenzyme A transferase
PF00378 (11/11) Enoyl-CoA hydratase/isomerase
PF00196 (11/11) Bacterial regulatory proteins, luxR family
PF00109 (11/11) Beta-ketoacyl synthase, N-terminal domain
PF00106 (11/11) short chain dehydrogenase
PF00005 (11/11) ABC transporter
PF12679 (10/11) ABC-2 family transporter protein
TIGR00976 (9/11) hydrolase CocE/NonD family protein
PF13193 (9/11) AMP-binding enzyme C-terminal domain
PF08530 (9/11) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/11) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/11) AMP-binding enzyme
PF04909 (8/11) Amidohydrolase
PF12697 (7/11) Alpha/beta hydrolase family
precursor_jaccard_groups_9145 12.90 +- 0.99 5 0 0 0 0.23 +- 0.04 5 5

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF04909 (5/5) Amidohydrolase
PF01575 (5/5) MaoC like domain
PF00501 (5/5) AMP-binding enzyme
precursor_jaccard_groups_41772 79.47 +- 31.10 2 0 0 0 0.04 +- 0.03 2 4

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (2/2) UTRA domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_6553 39.28 +- 2.72 2 0 0 0 0.23 +- 0.36 2 8

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03815 (2/2) helicase/secretion neighborhood CpaE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03816 (1/2) helicase/secretion neighborhood TadE-like protein
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
precursor_jaccard_groups_17307 280.43 +- 183.86 3 0 0 0 0.02 +- 0.05 3 4

PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF00294 (3/3) pfkB family carbohydrate kinase
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
precursor_jaccard_groups_20099 691.01 +- 84.49 3 0 3 0 0.07 +- 0.18 3 17

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18456 (3/3) Diiron non-heme beta-hydroxylase N-terminal domain
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF12706 (3/3) Beta-lactamase superfamily domain
PF12697 (3/3) Alpha/beta hydrolase family
PF03621 (3/3) MbtH-like protein
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (3/3) ParB-like nuclease domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17301 305.62 +- 233.24 3 0 3 0 0.03 +- 0.04 3 9

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF08659 (3/3) KR domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_3616 172.90 +- 64.45 9 0 0 0 0.10 +- 0.14 9 11

TIGR01726 (9/9) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF01244 (9/9) Membrane dipeptidase (Peptidase family M19)
PF00583 (9/9) Acetyltransferase (GNAT) family
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00497 (9/9) Bacterial extracellular solute-binding proteins, family 3
PF00005 (9/9) ABC transporter
TIGR00976 (8/9) hydrolase CocE/NonD family protein
PF08530 (8/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/9) X-Pro dipeptidyl-peptidase (S15 family)
PF00296 (6/9) Luciferase-like monooxygenase
PF07690 (5/9) Major Facilitator Superfamily
precursor_jaccard_groups_24088 84.67 +- 18.80 2 0 1 0 0.15 +- 0.16 2 14

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF10518 (2/2) TAT (twin-arginine translocation) pathway signal sequence
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_13492 694.36 +- 239.48 4 0 4 0 0.03 +- 0.03 4 26

TIGR01733 (4/4) amino acid adenylation domain
PF18563 (4/4) TubC N-terminal docking domain
PF16653 (4/4) Saccharopine dehydrogenase C-terminal domain
PF14518 (4/4) Iron-containing redox enzyme
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF13535 (4/4) ATP-grasp domain
PF13434 (4/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF09334 (4/4) tRNA synthetases class I (M)
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF05222 (4/4) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (4/4) Saccharopine dehydrogenase NADP binding domain
PF03417 (4/4) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01266 (4/4) FAD dependent oxidoreductase
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (3/4) Cytochrome P450
precursor_jaccard_groups_13023 328.72 +- 190.80 4 0 0 0 0.02 +- 0.02 4 9

TIGR00167 (4/4) ketose-bisphosphate aldolase
PF17042 (4/4) Nucleotide-binding C-terminal domain
PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (4/4) GntP family permease
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00392 (4/4) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_29183 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_21846 163.22 +- 148.78 2 0 0 0 0.11 +- 0.26 2 4

TIGR00813 (2/2) transporter, solute:sodium symporter (SSS) family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00485 (2/2) Phosphoribulokinase / Uridine kinase family
PF00474 (2/2) Sodium:solute symporter family
precursor_jaccard_groups_34651 294.20 +- 221.80 2 0 0 0 0.06 +- 0.20 2 9

PF11723 (2/2) Homotrimeric ring hydroxylase
PF03972 (2/2) MmgE/PrpD family
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF00561 (2/2) alpha/beta hydrolase fold
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_43056 112.24 +- 3.04 2 0 0 0 0.03 +- 0.03 2 6

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07519 (2/2) Tannase and feruloyl esterase
PF05685 (2/2) Putative restriction endonuclease
PF00589 (2/2) Phage integrase family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_3981 382.54 +- 121.74 9 0 7 9 0.01 +- 0.00 9 4

PF07690 (9/9) Major Facilitator Superfamily
PF05711 (9/9) Macrocin-O-methyltransferase (TylF)
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF13649 (8/9) Methyltransferase domain
precursor_jaccard_groups_23683 109.86 +- 0.00 2 0 0 0 0.09 +- 0.00 2 8

PF13407 (2/2) Periplasmic binding protein domain
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF06283 (2/2) Trehalose utilisation
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00801 (2/2) PKD domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_42614 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain
precursor_jaccard_groups_9606 777.00 +- 3.00 2 0 2 0 0.01 +- 0.00 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00464 (2/2) Serine hydroxymethyltransferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_9607 43.71 +- 9.40 5 0 0 0 0.15 +- 0.15 5 18

TIGR01374 (5/5) sarcosine oxidase, delta subunit family
TIGR01373 (5/5) sarcosine oxidase, beta subunit family
TIGR01372 (5/5) sarcosine oxidase, alpha subunit family
PF17806 (5/5) Sarcosine oxidase A3 domain
PF16350 (5/5) FAD dependent oxidoreductase central domain
PF13516 (5/5) Leucine Rich repeat
PF13203 (5/5) Putative metallopeptidase domain
PF09967 (5/5) VWA-like domain (DUF2201)
PF08669 (5/5) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF07728 (5/5) AAA domain (dynein-related subfamily)
PF04268 (5/5) Sarcosine oxidase, gamma subunit family
PF04267 (5/5) Sarcosine oxidase, delta subunit family
PF02882 (5/5) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (5/5) Aminomethyltransferase folate-binding domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00763 (5/5) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF13510 (4/5) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_9605 1015.29 +- 590.98 5 0 0 0 0.01 +- 0.01 5 5

PF08666 (5/5) SAF domain
PF07811 (5/5) TadE-like protein
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF01476 (4/5) LysM domain
precursor_jaccard_groups_730 234.79 +- 200.58 2 0 0 2 0.05 +- 0.14 2 6

PF13599 (2/2) Pentapeptide repeats (9 copies)
PF04055 (2/2) Radical SAM superfamily
PF13560 (1/2) Helix-turn-helix domain
PF08241 (1/2) Methyltransferase domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF00248 (1/2) Aldo/keto reductase family
precursor_jaccard_groups_3969 473.15 +- 166.50 7 0 0 0 0.04 +- 0.01 7 5

PF13407 (7/7) Periplasmic binding protein domain
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF01261 (7/7) Xylose isomerase-like TIM barrel
PF00652 (7/7) Ricin-type beta-trefoil lectin domain
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_43909 13.43 +- 2.89 2 0 0 0 0.22 +- 0.19 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00501 (2/2) AMP-binding enzyme
PF01145 (1/2) SPFH domain / Band 7 family
PF00877 (1/2) NlpC/P60 family
precursor_jaccard_groups_17104 85.16 +- 50.82 3 0 0 0 0.11 +- 0.25 3 14

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14525 (3/3) AraC-binding-like domain
PF13458 (3/3) Periplasmic binding protein
PF12840 (3/3) Helix-turn-helix domain
PF12833 (3/3) Helix-turn-helix domain
PF11774 (3/3) Lsr2
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit
PF01425 (3/3) Amidase
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_jaccard_groups_13787 251.45 +- 195.83 4 0 0 0 0.03 +- 0.07 4 6

PF00082 (4/4) Subtilase family
TIGR03930 (3/4) WXG100 family type VII secretion target
PF06013 (3/4) Proteins of 100 residues with WXG
TIGR03921 (2/4) type VII secretion-associated serine protease mycosin
TIGR03919 (2/4) type VII secretion protein EccB
PF05108 (2/4) Type VII secretion system ESX-1, transport TM domain B
precursor_jaccard_groups_3967 108.92 +- 28.27 4 0 4 0 0.12 +- 0.27 4 19

PF18605 (4/4) Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF14759 (4/4) Reductase C-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF08659 (4/4) KR domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF06368 (4/4) Methylaspartate mutase E chain (MutE)
PF02909 (4/4) Tetracyclin repressor-like, C-terminal domain
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (4/4) B12 binding domain
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_1861 145.88 +- 116.91 16 0 1 0 0.16 +- 0.22 16 26

PF13244 (14/16) Domain of unknown function (DUF4040)
PF09364 (14/16) XFP N-terminal domain
PF09363 (14/16) XFP C-terminal domain
PF04066 (14/16) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF03894 (14/16) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF00420 (14/16) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (14/16) Proton-conducting membrane transporter
PF04879 (13/16) Molybdopterin oxidoreductase Fe4S4 domain
PF04039 (13/16) Domain related to MnhB subunit of Na+/H+ antiporter
PF01568 (13/16) Molydopterin dinucleotide binding domain
PF00667 (13/16) FAD binding domain
PF00384 (13/16) Molybdopterin oxidoreductase
PF00258 (13/16) Flavodoxin
PF00175 (13/16) Oxidoreductase NAD-binding domain
PF14759 (12/16) Reductase C-terminal
PF07992 (12/16) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (12/16) Major Facilitator Superfamily
PF06276 (12/16) Ferric iron reductase FhuF-like transporter
PF04183 (12/16) IucA / IucC family
PF02784 (12/16) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01497 (12/16) Periplasmic binding protein
PF00005 (12/16) ABC transporter
PF01032 (11/16) FecCD transport family
PF13535 (10/16) ATP-grasp domain
PF03328 (9/16) HpcH/HpaI aldolase/citrate lyase family
PF18130 (8/16) ATP-grasp N-terminal domain
precursor_jaccard_groups_10078 12.85 +- 1.22 5 0 0 0 0.16 +- 0.03 5 2

PF08445 (5/5) FR47-like protein
PF00106 (5/5) short chain dehydrogenase
precursor_jaccard_groups_955 485.95 +- 620.87 36 3 33 36 0.07 +- 0.21 33 12

PF13471 (36/36) Transglutaminase-like superfamily
PF05402 (36/36) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (36/36) ABC-2 type transporter
PF00733 (36/36) Asparagine synthase
PF00005 (36/36) ABC transporter
PF13462 (34/36) Thioredoxin
PF12730 (34/36) ABC-2 family transporter protein
PF09587 (31/36) Bacterial capsule synthesis protein PGA_cap
PF07291 (28/36) Methylamine utilisation protein MauE
PF07730 (27/36) Histidine kinase
PF00196 (24/36) Bacterial regulatory proteins, luxR family
PF00072 (24/36) Response regulator receiver domain
precursor_jaccard_groups_14764 23.05 +- 4.81 2 0 0 0 0.11 +- 0.16 2 7

TIGR02434 (2/2) precorrin-6A synthase (deacetylating)
PF12796 (2/2) Ankyrin repeats (3 copies)
PF03745 (2/2) Domain of unknown function (DUF309)
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12802 (1/2) MarR family
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_32371 101.11 +- 6.89 2 0 0 0 0.12 +- 0.22 2 7

PF12679 (2/2) ABC-2 family transporter protein
PF07883 (2/2) Cupin domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32370 27.85 +- 4.40 2 0 0 0 0.11 +- 0.13 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF08751 (2/2) TrwC relaxase
PF03466 (2/2) LysR substrate binding domain
PF00872 (2/2) Transposase, Mutator family
PF00293 (2/2) NUDIX domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_35896 276.43 +- 110.57 2 0 2 0 0.03 +- 0.02 2 16

TIGR03947 (2/2) capreomycidine synthase
TIGR03946 (2/2) arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependent
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_35670 186.14 +- 8.86 2 0 0 0 0.03 +- 0.01 2 9

PF13808 (2/2) DDE_Tnp_1-associated
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01609 (2/2) Transposase DDE domain
PF01596 (2/2) O-methyltransferase
PF01494 (2/2) FAD binding domain
PF00581 (2/2) Rhodanese-like domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_35898 106.96 +- 34.94 2 0 0 0 0.07 +- 0.03 2 13

PF17645 (2/2) Arylmalonate decarboxylase
PF12697 (2/2) Alpha/beta hydrolase family
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01494 (2/2) FAD binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (2/2) MarR family
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00857 (2/2) Isochorismatase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_6061 47.76 +- 34.35 7 0 7 0 0.05 +- 0.04 7 4

PF02776 (7/7) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (7/7) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (7/7) Thiamine pyrophosphate enzyme, central domain
PF00171 (7/7) Aldehyde dehydrogenase family
precursor_jaccard_groups_18446 8.57 +- 0.00 2 0 0 0 0.23 +- 0.31 2 3

TIGR02469 (2/2) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
TIGR01465 (2/2) precorrin-4 C11-methyltransferase
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
precursor_jaccard_groups_2566 114.33 +- 17.12 5 0 0 0 0.11 +- 0.06 5 10

TIGR01382 (5/5) intracellular protease, PfpI family
PF13823 (5/5) Alcohol dehydrogenase GroES-associated
PF09123 (5/5) Domain of unknown function (DUF1931)
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF01965 (5/5) DJ-1/PfpI family
PF00248 (5/5) Aldo/keto reductase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF13515 (4/5) Fusaric acid resistance protein-like
PF12805 (4/5) FUSC-like inner membrane protein yccS
precursor_jaccard_groups_42502 56.28 +- 1.74 2 0 0 0 0.17 +- 0.13 2 5

PF09084 (2/2) NMT1/THI5 like
PF01145 (2/2) SPFH domain / Band 7 family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_42054 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00534 (2/2) Glycosyl transferases group 1
precursor_jaccard_groups_2560 812.71 +- 692.59 4 0 0 4 0.02 +- 0.02 4 11

TIGR00702 (4/4) YcaO-type kinase domain
PF13649 (4/4) Methyltransferase domain
PF07812 (4/4) TfuA-like protein
PF07479 (4/4) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01210 (4/4) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
TIGR02937 (2/4) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/4) Sigma-70, region 4
PF08241 (2/4) Methyltransferase domain
PF04542 (2/4) Sigma-70 region 2
PF01614 (2/4) Bacterial transcriptional regulator
precursor_jaccard_groups_2561 277.35 +- 238.65 2 0 0 0 0.03 +- 0.05 2 2

PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
precursor_jaccard_groups_26023 297.63 +- 115.17 2 0 2 0 0.05 +- 0.06 2 7

TIGR00157 (2/2) ribosome small subunit-dependent GTPase A
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13649 (2/2) Methyltransferase domain
PF03193 (2/2) RsgA GTPase
PF01061 (2/2) ABC-2 type transporter
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3916 94.31 +- 11.27 2 0 0 0 0.11 +- 0.22 2 26

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
TIGR02378 (2/2) nitrite reductase [NAD(P)H], small subunit
TIGR02374 (2/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (2/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (2/2) Rieske-like [2Fe-2S] domain
PF13520 (2/2) Amino acid permease
PF12840 (2/2) Helix-turn-helix domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF08327 (2/2) Activator of Hsp90 ATPase homolog 1-like protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07398 (2/2) MDMPI C-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03460 (2/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (2/2) Nitrite and sulphite reductase 4Fe-4S domain
PF00106 (2/2) short chain dehydrogenase
PF16640 (1/2) Bacterial Ig-like domain (group 3)
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07098 (1/2) Protein of unknown function (DUF1360)
PF06271 (1/2) RDD family
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01810 (1/2) LysE type translocator
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_10679 9.00 +- 0.00 2 0 0 0 0.22 +- 0.15 2 2

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_14306 20.18 +- 2.70 3 0 0 0 0.20 +- 0.15 3 10

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13247 (3/3) 4Fe-4S dicluster domain
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_jaccard_groups_35998 229.33 +- 114.67 2 0 2 0 0.02 +- 0.02 2 4

PF07681 (2/2) DoxX
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF02515 (2/2) CoA-transferase family III
PF00285 (2/2) Citrate synthase, C-terminal domain
precursor_jaccard_groups_39261 696.60 +- 77.40 2 0 2 2 0.01 +- 0.00 2 9

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR00702 (2/2) YcaO-type kinase domain
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF08007 (2/2) Cupin superfamily protein
PF07812 (2/2) TfuA-like protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_20297 111.13 +- 95.50 3 0 0 0 0.10 +- 0.18 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF16347 (3/3) Domain of unknown function (DUF4976)
PF13560 (3/3) Helix-turn-helix domain
PF09992 (3/3) Phosphodiester glycosidase
PF05036 (3/3) Sporulation related domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF04149 (3/3) Domain of unknown function (DUF397)
PF00884 (3/3) Sulfatase
PF00756 (3/3) Putative esterase
precursor_jaccard_groups_36278 155.05 +- 102.95 2 0 2 0 0.04 +- 0.06 2 23

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08241 (2/2) Methyltransferase domain
PF07993 (2/2) Male sterility protein
PF01695 (2/2) IstB-like ATP binding protein
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00665 (2/2) Integrase core domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF03358 (1/2) NADPH-dependent FMN reductase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (1/2) Thioesterase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_11416 28.59 +- 7.25 4 0 0 0 0.07 +- 0.03 4 6

TIGR00229 (4/4) PAS domain S-box protein
PF08448 (4/4) PAS fold
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF01590 (4/4) GAF domain
PF00989 (4/4) PAS fold
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_19793 123.10 +- 101.52 3 0 1 0 0.15 +- 0.15 3 4

PF11706 (3/3) CGNR zinc finger
PF07336 (3/3) Putative stress-induced transcription regulator
PF00005 (3/3) ABC transporter
PF00561 (2/3) alpha/beta hydrolase fold
precursor_jaccard_groups_6648 45.88 +- 12.90 3 0 0 0 0.11 +- 0.07 3 8

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_41550 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase
precursor_jaccard_groups_1598 57.96 +- 12.04 2 0 0 2 0.05 +- 0.10 2 9

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily
precursor_jaccard_groups_39616 38.62 +- 15.17 2 0 0 0 0.06 +- 0.10 2 5

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF14016 (2/2) Protein of unknown function (DUF4232)
PF12840 (2/2) Helix-turn-helix domain
PF08044 (2/2) Domain of unknown function (DUF1707)
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_4515 270.26 +- 140.91 4 0 0 0 0.03 +- 0.05 4 8

PF12696 (4/4) TraM recognition site of TraD and TraG
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF00772 (4/4) DnaB-like helicase N terminal domain
PF00145 (4/4) C-5 cytosine-specific DNA methylase
PF02899 (3/4) Phage integrase, N-terminal SAM-like domain
PF00535 (3/4) Glycosyl transferase family 2
precursor_jaccard_groups_18660 237.30 +- 29.18 3 0 3 0 0.01 +- 0.00 3 6

TIGR01926 (3/3) uncharacterized peroxidase-related enzyme
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF07690 (3/3) Major Facilitator Superfamily
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_41429 17.69 +- 0.74 2 0 0 0 0.11 +- 0.13 2 3

TIGR00099 (2/2) Cof-like hydrolase
PF09335 (2/2) SNARE associated Golgi protein
PF08282 (2/2) haloacid dehalogenase-like hydrolase
precursor_jaccard_groups_41428 182.00 +- 52.00 2 0 0 0 0.02 +- 0.01 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF03928 (2/2) Haem-degrading
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_15368 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_9136 465.60 +- 61.73 5 0 5 0 0.01 +- 0.00 5 5

PF05977 (5/5) Transmembrane secretion effector
PF05893 (5/5) Acyl-CoA reductase (LuxC)
PF04443 (5/5) Acyl-protein synthetase, LuxE
PF03756 (5/5) A-factor biosynthesis hotdog domain
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_jaccard_groups_13476 555.59 +- 532.35 4 0 0 0 0.02 +- 0.02 4 10

PF07729 (4/4) FCD domain
PF07690 (4/4) Major Facilitator Superfamily
PF05378 (4/4) Hydantoinase/oxoprolinase N-terminal region
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02538 (4/4) Hydantoinase B/oxoprolinase
PF01968 (4/4) Hydantoinase/oxoprolinase
PF01558 (4/4) Pyruvate ferredoxin/flavodoxin oxidoreductase
PF00857 (4/4) Isochorismatase family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00155 (4/4) Aminotransferase class I and II
precursor_jaccard_groups_9130 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_41424 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF05534 (2/2) HicB family
precursor_jaccard_groups_35323 61.09 +- 32.05 2 0 0 2 0.12 +- 0.18 2 12

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF08962 (2/2) Domain of unknown function (DUF1876)
PF08940 (2/2) Domain of unknown function (DUF1918)
PF03633 (2/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (2/2) Glycosyl hydrolase family 65 central catalytic domain
PF00881 (2/2) Nitroreductase family
PF17203 (1/2) Single cache domain 3
PF13581 (1/2) Histidine kinase-like ATPase domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01590 (1/2) GAF domain
precursor_jaccard_groups_13679 32.05 +- 11.03 3 0 3 0 0.11 +- 0.09 3 2

PF02031 (3/3) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (3/3) LysE type translocator
precursor_jaccard_groups_31970 157.48 +- 132.77 2 0 0 0 0.07 +- 0.13 2 4

TIGR03666 (2/2) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07690 (2/2) Major Facilitator Superfamily
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_13671 461.13 +- 364.31 4 0 0 0 0.08 +- 0.19 4 18

TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01428 (4/4) haloacid dehalogenase, type II
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (4/4) FCD domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00005 (4/4) ABC transporter
TIGR01297 (3/4) cation diffusion facilitator family transporter
PF16916 (3/4) Dimerisation domain of Zinc Transporter
PF01545 (3/4) Cation efflux family
PF00171 (3/4) Aldehyde dehydrogenase family
PF17189 (2/4) Glycosyl hydrolase family 30 beta sandwich domain
PF12840 (2/4) Helix-turn-helix domain
PF07690 (2/4) Major Facilitator Superfamily
PF00581 (2/4) Rhodanese-like domain
precursor_jaccard_groups_13676 313.28 +- 231.83 4 0 0 0 0.03 +- 0.04 4 6

TIGR01751 (4/4) crotonyl-CoA carboxylase/reductase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF01047 (4/4) MarR family
PF00857 (4/4) Isochorismatase family
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_jaccard_groups_23023 56.60 +- 20.75 3 0 0 0 0.12 +- 0.07 3 8

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_41956 645.32 +- 489.88 2 0 0 0 0.07 +- 0.21 2 11

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
precursor_jaccard_groups_37046 19.59 +- 0.00 2 0 0 0 0.15 +- 0.17 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF04542 (2/2) Sigma-70 region 2
PF04264 (2/2) YceI-like domain
PF01471 (2/2) Putative peptidoglycan binding domain
PF00413 (2/2) Matrixin
precursor_jaccard_groups_42879 21.48 +- 7.72 2 0 0 0 0.12 +- 0.13 2 5

PF09335 (2/2) SNARE associated Golgi protein
PF07730 (2/2) Histidine kinase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_15412 138.46 +- 43.67 3 0 0 0 0.03 +- 0.02 3 9

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_8397 117.56 +- 43.17 4 0 4 0 0.10 +- 0.18 4 10

TIGR03885 (4/4) probable non-F420 flavinoid oxidoreductase
PF18306 (4/4) SLOG cluster4 family
PF16657 (4/4) Maltogenic Amylase, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03641 (4/4) Possible lysine decarboxylase
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (4/4) Polysaccharide deacetylase
PF00553 (4/4) Cellulose binding domain
PF00296 (4/4) Luciferase-like monooxygenase
PF00128 (4/4) Alpha amylase, catalytic domain
precursor_jaccard_groups_14945 22.32 +- 2.76 3 0 3 0 0.13 +- 0.09 3 5

TIGR02824 (3/3) putative NAD(P)H quinone oxidoreductase, PIG3 family
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07859 (3/3) alpha/beta hydrolase fold
PF01965 (3/3) DJ-1/PfpI family
PF13602 (2/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_32001 388.50 +- 1.50 2 0 0 0 0.01 +- 0.00 2 9

TIGR01205 (2/2) D-alanine--D-alanine ligase
TIGR00492 (2/2) alanine racemase
PF13560 (2/2) Helix-turn-helix domain
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF04149 (2/2) Domain of unknown function (DUF397)
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00842 (2/2) Alanine racemase, C-terminal domain
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
precursor_jaccard_groups_15418 214.79 +- 38.91 3 0 3 0 0.03 +- 0.02 3 13

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00296 (3/3) Luciferase-like monooxygenase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_27032 60.31 +- 29.11 2 0 0 0 0.15 +- 0.20 2 6

TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_22003 84.93 +- 58.51 3 0 0 0 0.16 +- 0.17 3 9

TIGR00996 (3/3) virulence factor Mce family protein
PF13814 (3/3) Replication-relaxation
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/3) Sigma-70, region 4
PF04542 (2/3) Sigma-70 region 2
precursor_jaccard_groups_27037 320.46 +- 139.19 2 0 2 0 0.04 +- 0.03 2 12

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (2/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF12849 (2/2) PBP superfamily domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF01676 (2/2) Metalloenzyme superfamily
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00384 (2/2) Molybdopterin oxidoreductase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (2/2) Glutamine amidotransferase class-I
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1288 57.09 +- 28.29 9 0 0 0 0.04 +- 0.04 9 4

PF10974 (9/9) Protein of unknown function (DUF2804)
PF05922 (9/9) Peptidase inhibitor I9
PF01483 (9/9) Proprotein convertase P-domain
PF00082 (9/9) Subtilase family
precursor_jaccard_groups_41776 285.38 +- 234.62 2 0 0 0 0.04 +- 0.11 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_41778 645.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08659 (2/2) KR domain
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_1282 270.77 +- 162.57 28 0 28 0 0.04 +- 0.10 28 13

TIGR00709 (28/28) 2,4-diaminobutyrate 4-transaminase
TIGR00657 (28/28) aspartate kinase
PF13434 (28/28) L-lysine 6-monooxygenase (NADPH-requiring)
PF07690 (28/28) Major Facilitator Superfamily
PF04204 (28/28) Homoserine O-succinyltransferase
PF00696 (28/28) Amino acid kinase family
PF00202 (28/28) Aminotransferase class-III
PF00668 (26/28) Condensation domain
PF00501 (26/28) AMP-binding enzyme
TIGR01733 (25/28) amino acid adenylation domain
PF13193 (25/28) AMP-binding enzyme C-terminal domain
PF00975 (25/28) Thioesterase domain
PF00550 (25/28) Phosphopantetheine attachment site
precursor_jaccard_groups_6485 69.40 +- 80.65 7 0 0 0 0.09 +- 0.06 7 7

TIGR03930 (7/7) WXG100 family type VII secretion target
TIGR03919 (7/7) type VII secretion protein EccB
PF06013 (7/7) Proteins of 100 residues with WXG
PF05108 (7/7) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (6/7) type VII secretion integral membrane protein EccD
PF08817 (6/7) WXG100 protein secretion system (Wss), protein YukD
PF02575 (4/7) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_42594 43.69 +- 3.22 2 0 0 0 0.09 +- 0.08 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_1600 37.17 +- 24.00 23 0 0 0 0.09 +- 0.08 23 3

PF04464 (23/23) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (23/23) Glycosyl transferase family 2
PF00534 (23/23) Glycosyl transferases group 1
precursor_jaccard_groups_41395 80.48 +- 6.19 2 0 0 0 0.03 +- 0.01 2 4

PF08592 (2/2) Domain of unknown function (DUF1772)
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF00394 (2/2) Multicopper oxidase
precursor_jaccard_groups_18062 255.64 +- 55.48 3 0 0 0 0.09 +- 0.22 3 21

TIGR01928 (3/3) o-succinylbenzoate synthase
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (3/3) Enolase C-terminal domain-like
PF12831 (3/3) FAD dependent oxidoreductase
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (3/3) CoA-transferase family III
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF01546 (3/3) Peptidase family M20/M25/M40
PF01381 (3/3) Helix-turn-helix
PF01380 (3/3) SIS domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_10095 85.33 +- 49.96 5 0 5 0 0.11 +- 0.19 5 8

PF12704 (5/5) MacB-like periplasmic core domain
PF02687 (5/5) FtsX-like permease family
PF02153 (5/5) Prephenate dehydrogenase
PF01471 (5/5) Putative peptidoglycan binding domain
PF01243 (5/5) Pyridoxamine 5'-phosphate oxidase
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
TIGR03618 (4/5) PPOX class probable F420-dependent enzyme
precursor_jaccard_groups_15094 496.17 +- 214.03 3 0 0 0 0.01 +- 0.02 3 9

PF12697 (3/3) Alpha/beta hydrolase family
PF03704 (3/3) Bacterial transcriptional activator domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02036 (3/3) SCP-2 sterol transfer family
PF01425 (3/3) Amidase
PF00899 (3/3) ThiF family
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_11307 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_10258 19.85 +- 5.46 5 0 0 0 0.11 +- 0.11 5 2

PF11203 (5/5) Putative type VII ESX secretion system translocon, EccE
PF00877 (5/5) NlpC/P60 family
precursor_jaccard_groups_5117 23.30 +- 0.63 3 0 0 0 0.09 +- 0.05 3 4

TIGR00008 (3/3) translation initiation factor IF-1
PF13673 (3/3) Acetyltransferase (GNAT) domain
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF01176 (3/3) Translation initiation factor 1A / IF-1
precursor_jaccard_groups_35874 69.12 +- 27.63 2 0 0 0 0.05 +- 0.07 2 9

TIGR02115 (2/2) K+-transporting ATPase, F subunit
PF13493 (2/2) Domain of unknown function (DUF4118)
PF12746 (2/2) GNAT acetyltransferase
PF09604 (2/2) F subunit of K+-transporting ATPase (Potass_KdpF)
PF02702 (2/2) Osmosensitive K+ channel His kinase sensor domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00582 (2/2) Universal stress protein family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_36388 729.09 +- 209.09 2 0 2 0 0.01 +- 0.00 2 7

PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13454 (2/2) FAD-NAD(P)-binding
PF12897 (2/2) Alanine-glyoxylate amino-transferase
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_19564 14.51 +- 0.00 2 0 0 0 0.21 +- 0.10 2 6

TIGR00342 (2/2) tRNA sulfurtransferase ThiI
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02926 (2/2) THUMP domain
PF02568 (2/2) Thiamine biosynthesis protein (ThiI)
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_12037 59.34 +- 39.18 4 0 0 0 0.09 +- 0.22 4 7

PF10002 (4/4) Predicted membrane protein (DUF2243)
PF09678 (4/4) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF01814 (4/4) Hemerythrin HHE cation binding domain
PF09844 (3/4) Uncharacterized conserved protein (COG2071)
PF07228 (3/4) Stage II sporulation protein E (SpoIIE)
TIGR02891 (2/4) cytochrome c oxidase, subunit I
PF00115 (2/4) Cytochrome C and Quinol oxidase polypeptide I
precursor_jaccard_groups_37706 158.77 +- 13.23 2 0 0 0 0.08 +- 0.05 2 7

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_41379 26.57 +- 7.84 2 0 0 0 0.12 +- 0.08 2 6

PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13411 (2/2) MerR HTH family regulatory protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_5485 305.66 +- 186.24 7 0 6 0 0.07 +- 0.21 7 8

TIGR01181 (7/7) dTDP-glucose 4,6-dehydratase
PF17755 (7/7) UvrA DNA-binding domain
PF16363 (7/7) GDP-mannose 4,6 dehydratase
PF13460 (7/7) NAD(P)H-binding
PF05368 (7/7) NmrA-like family
PF03992 (7/7) Antibiotic biosynthesis monooxygenase
PF03559 (7/7) NDP-hexose 2,3-dehydratase
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_8172 47.99 +- 27.03 3 0 3 0 0.23 +- 0.35 3 16

TIGR01746 (3/3) thioester reductase domain
TIGR01686 (3/3) FkbH domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF12697 (3/3) Alpha/beta hydrolase family
PF08659 (3/3) KR domain
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_12782 64.02 +- 2.74 4 0 0 0 0.12 +- 0.12 4 10

PF13586 (4/4) Transposase DDE domain
PF12802 (4/4) MarR family
PF07690 (4/4) Major Facilitator Superfamily
PF01327 (4/4) Polypeptide deformylase
PF00857 (4/4) Isochorismatase family
PF00106 (4/4) short chain dehydrogenase
TIGR02957 (3/4) RNA polymerase sigma-70 factor, TIGR02957 family
PF12680 (3/4) SnoaL-like domain
PF08281 (3/4) Sigma-70, region 4
PF04542 (3/4) Sigma-70 region 2
precursor_jaccard_groups_36122 258.00 +- 129.00 2 0 2 2 0.02 +- 0.02 2 5

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_41370 8.39 +- 0.14 2 0 0 0 0.24 +- 0.08 2 2

PF01341 (2/2) Glycosyl hydrolases family 6
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_21447 394.46 +- 277.78 3 0 0 3 0.03 +- 0.08 3 9

TIGR04188 (3/3) methyltransferase, ATP-grasp peptide maturase system
PF13521 (3/3) AAA domain
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00929 (3/3) Exonuclease
PF00248 (3/3) Aldo/keto reductase family
PF00005 (3/3) ABC transporter
TIGR04187 (2/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/3) putative ATP-grasp target RiPP
PF14408 (2/3) Ribosomally synthesised peptide in actinomycetes
precursor_jaccard_groups_41178 134.11 +- 4.11 2 0 0 0 0.06 +- 0.09 2 15

TIGR03356 (2/2) beta-galactosidase
PF17189 (2/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF02055 (2/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01590 (2/2) GAF domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_16825 19.22 +- 6.18 3 0 0 0 0.15 +- 0.25 3 4

PF13641 (3/3) Glycosyltransferase like family 2
PF01757 (3/3) Acyltransferase family
PF01522 (3/3) Polysaccharide deacetylase
PF01381 (2/3) Helix-turn-helix
precursor_jaccard_groups_1131 380.60 +- 125.70 8 0 8 8 0.01 +- 0.01 8 4

PF13471 (8/8) Transglutaminase-like superfamily
PF00733 (8/8) Asparagine synthase
PF01135 (7/8) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF05402 (5/8) Coenzyme PQQ synthesis protein D (PqqD)
precursor_jaccard_groups_21115 77.20 +- 3.09 3 0 0 0 0.10 +- 0.17 3 15

TIGR01297 (3/3) cation diffusion facilitator family transporter
TIGR01048 (3/3) diaminopimelate decarboxylase
PF16916 (3/3) Dimerisation domain of Zinc Transporter
PF03098 (3/3) Animal haem peroxidase
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01764 (3/3) Lipase (class 3)
PF01565 (3/3) FAD binding domain
PF01545 (3/3) Cation efflux family
PF01494 (3/3) FAD binding domain
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00067 (3/3) Cytochrome P450
PF08241 (2/3) Methyltransferase domain
precursor_jaccard_groups_25707 225.44 +- 25.27 2 0 0 0 0.04 +- 0.02 2 9

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14310 (2/2) Fibronectin type III-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_16044 105.30 +- 22.13 3 0 0 0 0.06 +- 0.02 3 4

PF03466 (3/3) LysR substrate binding domain
PF01979 (3/3) Amidohydrolase family
PF00756 (3/3) Putative esterase
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_37684 128.36 +- 2.85 2 0 2 0 0.14 +- 0.12 2 6

PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_13921 757.17 +- 285.55 3 0 3 0 0.01 +- 0.00 3 11

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02566 (3/3) OsmC-like protein
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_77 159.87 +- 201.22 15 0 15 10 0.11 +- 0.22 15 6

PF00069 (15/15) Protein kinase domain
PF00664 (14/15) ABC transporter transmembrane region
PF00005 (14/15) ABC transporter
PF05147 (10/15) Lanthionine synthetase C-like protein
PF00171 (9/15) Aldehyde dehydrogenase family
PF13370 (8/15) 4Fe-4S single cluster domain of Ferredoxin I
precursor_jaccard_groups_19429 129.73 +- 81.36 2 0 0 0 0.05 +- 0.03 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF00667 (2/2) FAD binding domain
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00067 (2/2) Cytochrome P450
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF01670 (1/2) Glycosyl hydrolase family 12
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_19424 353.86 +- 232.14 3 0 0 0 0.06 +- 0.10 3 3

PF11338 (3/3) Protein of unknown function (DUF3140)
PF11160 (3/3) Hypervirulence associated proteins TUDOR domain
PF00857 (3/3) Isochorismatase family
precursor_jaccard_groups_37831 183.57 +- 34.20 2 0 2 0 0.11 +- 0.16 2 15

PF17677 (2/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (2/2) Alpha mannosidase middle domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (2/2) Trehalose utilisation
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF12802 (1/2) MarR family
PF05834 (1/2) Lycopene cyclase protein
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01209 (1/2) ubiE/COQ5 methyltransferase family
precursor_jaccard_groups_1043 70.92 +- 20.79 8 0 0 0 0.05 +- 0.05 8 5

PF16259 (8/8) Domain of unknown function (DUF4913)
PF12696 (8/8) TraM recognition site of TraD and TraG
PF01425 (8/8) Amidase
PF02882 (7/8) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (7/8) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_jaccard_groups_37837 369.47 +- 215.53 2 0 0 0 0.05 +- 0.09 2 8

PF14592 (2/2) Chondroitinase B
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01120 (2/2) Alpha-L-fucosidase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR03804 (1/2) parallel beta-helix repeat
PF05899 (1/2) Protein of unknown function (DUF861)
precursor_jaccard_groups_20933 128.07 +- 50.53 3 0 3 3 0.13 +- 0.13 3 12

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF03704 (3/3) Bacterial transcriptional activator domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (3/3) ABC-2 type transporter
PF00931 (3/3) NB-ARC domain
PF00881 (3/3) Nitroreductase family
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_1730 27.06 +- 5.19 2 0 0 0 0.09 +- 0.10 2 7

PF13516 (2/2) Leucine Rich repeat
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF14435 (1/2) SUKH-4 immunity protein
PF12796 (1/2) Ankyrin repeats (3 copies)
PF01738 (1/2) Dienelactone hydrolase family
precursor_jaccard_groups_20931 203.96 +- 84.80 3 0 0 0 0.07 +- 0.09 3 9

TIGR01972 (3/3) proton-translocating NADH-quinone oxidoreductase, chain M
PF07732 (3/3) Multicopper oxidase
PF07731 (3/3) Multicopper oxidase
PF00507 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (3/3) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00394 (3/3) Multicopper oxidase
PF00361 (3/3) Proton-conducting membrane transporter
PF00146 (3/3) NADH dehydrogenase
precursor_jaccard_groups_36499 1036.00 +- 4.00 2 0 0 0 0.01 +- 0.00 2 6

PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_37681 430.00 +- 215.00 2 0 0 0 0.03 +- 0.03 2 8

PF13378 (2/2) Enolase C-terminal domain-like
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_5273 195.65 +- 110.73 8 0 8 8 0.04 +- 0.14 8 5

TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term
PF05147 (8/8) Lanthionine synthetase C-like protein
PF04738 (8/8) Lantibiotic dehydratase, N terminus
PF00005 (7/8) ABC transporter
precursor_jaccard_groups_45092 37.45 +- 0.00 2 0 2 0 0.08 +- 0.05 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF00891 (2/2) O-methyltransferase domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_30541 260.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
precursor_jaccard_groups_30548 55.28 +- 3.51 2 0 2 0 0.18 +- 0.16 2 10

PF18029 (2/2) Glyoxalase-like domain
PF18011 (2/2) C-terminal domain found in long catalases
PF13520 (2/2) Amino acid permease
PF13439 (2/2) Glycosyltransferase Family 4
PF06628 (2/2) Catalase-related immune-responsive
PF04101 (2/2) Glycosyltransferase family 28 C-terminal domain
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF00534 (2/2) Glycosyl transferases group 1
PF00199 (2/2) Catalase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_29116 70.82 +- 5.01 2 0 0 0 0.20 +- 0.15 2 11

PF13646 (2/2) HEAT repeats
PF13411 (2/2) MerR HTH family regulatory protein
PF12838 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF07702 (2/2) UTRA domain
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF01638 (2/2) HxlR-like helix-turn-helix
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_550 231.17 +- 124.70 37 0 37 0 0.13 +- 0.23 37 23

PF00668 (37/37) Condensation domain
PF00501 (37/37) AMP-binding enzyme
PF00005 (37/37) ABC transporter
TIGR01733 (36/37) amino acid adenylation domain
TIGR01720 (36/37) non-ribosomal peptide synthase domain TIGR01720
PF13193 (36/37) AMP-binding enzyme C-terminal domain
PF02195 (36/37) ParB-like nuclease domain
PF00664 (36/37) ABC transporter transmembrane region
PF00550 (36/37) Phosphopantetheine attachment site
TIGR01361 (33/37) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (33/37) DAHP synthase ferredoxin-like domain
PF13592 (33/37) Winged helix-turn helix
PF13551 (33/37) Winged helix-turn helix
PF13370 (33/37) 4Fe-4S single cluster domain of Ferredoxin I
PF00975 (33/37) Thioesterase domain
PF00793 (33/37) DAHP synthetase I family
PF00196 (33/37) Bacterial regulatory proteins, luxR family
PF00067 (33/37) Cytochrome P450
PF04820 (32/37) Tryptophan halogenase
PF03621 (32/37) MbtH-like protein
PF00999 (31/37) Sodium/hydrogen exchanger family
PF13191 (29/37) AAA ATPase domain
PF13649 (19/37) Methyltransferase domain
precursor_jaccard_groups_43908 314.71 +- 56.71 2 0 2 0 0.01 +- 0.01 2 6

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08924 (2/2) Domain of unknown function (DUF1906)
PF06737 (2/2) Transglycosylase-like domain
PF01839 (2/2) FG-GAP repeat
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00293 (1/2) NUDIX domain
precursor_jaccard_groups_21204 13.49 +- 3.93 3 0 0 0 0.16 +- 0.09 3 2

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF04616 (3/3) Glycosyl hydrolases family 43
precursor_jaccard_groups_21200 398.33 +- 178.68 3 0 0 0 0.02 +- 0.01 3 8

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_21683 458.00 +- 289.51 3 0 3 3 0.04 +- 0.09 3 10

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF12804 (3/3) MobA-like NTP transferase domain
PF04055 (3/3) Radical SAM superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02310 (3/3) B12 binding domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_8771 176.42 +- 64.15 5 0 0 0 0.07 +- 0.05 5 8

PF13416 (5/5) Bacterial extracellular solute-binding protein
PF01266 (5/5) FAD dependent oxidoreductase
PF00005 (5/5) ABC transporter
TIGR01428 (4/5) haloacid dehalogenase, type II
PF13419 (4/5) Haloacid dehalogenase-like hydrolase
PF08402 (4/5) TOBE domain
PF00528 (4/5) Binding-protein-dependent transport system inner membrane component
PF00171 (4/5) Aldehyde dehydrogenase family
precursor_jaccard_groups_29077 183.91 +- 13.29 2 0 0 0 0.08 +- 0.06 2 18

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_jaccard_groups_36720 1501.25 +- 318.75 2 0 2 2 0.01 +- 0.00 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
TIGR00032 (2/2) argininosuccinate synthase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00764 (2/2) Arginosuccinate synthase
PF00733 (2/2) Asparagine synthase
PF00668 (2/2) Condensation domain
PF00581 (2/2) Rhodanese-like domain
PF00578 (2/2) AhpC/TSA family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00206 (2/2) Lyase
PF04299 (1/2) Putative FMN-binding domain
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
precursor_jaccard_groups_5279 161.77 +- 52.50 8 0 0 0 0.07 +- 0.08 8 6

PF09362 (8/8) Domain of unknown function (DUF1996)
PF03713 (8/8) Domain of unknown function (DUF305)
PF02861 (8/8) Clp amino terminal domain, pathogenicity island component
PF01061 (8/8) ABC-2 type transporter
PF00005 (8/8) ABC transporter
PF00754 (6/8) F5/8 type C domain
precursor_jaccard_groups_20240 53.09 +- 29.49 3 0 0 0 0.13 +- 0.12 3 13

TIGR03217 (3/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (3/3) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (3/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (3/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (3/3) DmpG-like communication domain
PF04909 (3/3) Amidohydrolase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (3/3) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (3/3) Endoribonuclease L-PSP
PF00682 (3/3) HMGL-like
PF00171 (3/3) Aldehyde dehydrogenase family
TIGR03037 (2/3) 3-hydroxyanthranilate 3,4-dioxygenase
PF06052 (2/3) 3-hydroxyanthranilic acid dioxygenase
precursor_jaccard_groups_20791 1075.46 +- 244.07 3 0 0 0 0.02 +- 0.02 3 6

PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF03704 (3/3) Bacterial transcriptional activator domain
PF01476 (3/3) LysM domain
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
precursor_jaccard_groups_16313 24.63 +- 5.72 2 0 0 0 0.09 +- 0.06 2 5

PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_jaccard_groups_25365 42.04 +- 0.96 2 0 0 0 0.12 +- 0.12 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02156 (2/2) Glycosyl hydrolase family 26
PF01943 (2/2) Polysaccharide biosynthesis protein
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_20246 126.71 +- 45.68 3 0 0 0 0.06 +- 0.07 3 13

TIGR00778 (3/3) alkylhydroperoxidase AhpD family core domain
TIGR00566 (3/3) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (3/3) aminodeoxychorismate synthase, component I
PF12876 (3/3) Sugar-binding cellulase-like
PF08962 (3/3) Domain of unknown function (DUF1876)
PF07690 (3/3) Major Facilitator Superfamily
PF04715 (3/3) Anthranilate synthase component I, N terminal region
PF03702 (3/3) Anhydro-N-acetylmuramic acid kinase
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01063 (3/3) Amino-transferase class IV
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF00083 (3/3) Sugar (and other) transporter
precursor_jaccard_groups_315 457.99 +- 459.00 10 0 10 10 0.03 +- 0.05 10 8

TIGR04363 (10/10) FxLD family lantipeptide
TIGR03891 (10/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (10/10) Lantibiotic biosynthesis dehydratase C-term
PF05147 (10/10) Lanthionine synthetase C-like protein
PF04738 (10/10) Lantibiotic dehydratase, N terminus
TIGR04364 (9/10) methyltransferase, FxLD system
PF01135 (9/10) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (9/10) ABC transporter
precursor_jaccard_groups_20248 597.28 +- 327.05 3 0 0 0 0.03 +- 0.03 3 17

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (3/3) tRNA synthetases class I (M)
PF08031 (3/3) Berberine and berberine like
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF07883 (3/3) Cupin domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02274 (3/3) Amidinotransferase
PF01613 (3/3) Flavin reductase like domain
PF01565 (3/3) FAD binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF07690 (2/3) Major Facilitator Superfamily
PF05425 (2/3) Copper resistance protein D
PF04234 (2/3) CopC domain
precursor_jaccard_groups_44470 602.85 +- 47.15 2 0 2 0 0.01 +- 0.01 2 17

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF08242 (2/2) Methyltransferase domain
PF04820 (2/2) Tryptophan halogenase
PF03061 (2/2) Thioesterase superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_30768 456.88 +- 26.88 2 0 0 0 0.01 +- 0.01 2 6

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01756 (2/2) Acyl-CoA oxidase
PF00698 (2/2) Acyl transferase domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_20799 22.91 +- 1.43 2 0 0 0 0.22 +- 0.23 2 9

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF05853 (2/2) beta-keto acid cleavage enzyme
PF04248 (2/2) Domain of unknown function (DUF427)
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_17790 172.33 +- 85.67 2 0 0 0 0.02 +- 0.01 2 2

PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00920 (2/2) Dehydratase family
precursor_jaccard_groups_14021 75.90 +- 32.99 4 0 0 0 0.15 +- 0.23 4 8

TIGR03444 (4/4) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
PF13620 (4/4) Carboxypeptidase regulatory-like domain
PF13088 (4/4) BNR repeat-like domain
PF11695 (4/4) Domain of unknown function (DUF3291)
PF04264 (4/4) YceI-like domain
PF04248 (4/4) Domain of unknown function (DUF427)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF04978 (3/4) Protein of unknown function (DUF664)
precursor_jaccard_groups_21063 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_jaccard_groups_29092 1309.55 +- 19.55 2 0 0 0 0.01 +- 0.00 2 10

PF13560 (2/2) Helix-turn-helix domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13144 (1/2) Chaperone for flagella basal body P-ring formation
PF08666 (1/2) SAF domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_42477 83.87 +- 0.00 2 0 2 2 0.12 +- 0.29 2 18

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13537 (2/2) Glutamine amidotransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01177 (2/2) Asp/Glu/Hydantoin racemase
PF00733 (2/2) Asparagine synthase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_792 476.56 +- 396.04 24 0 10 24 0.08 +- 0.15 24 20

TIGR04364 (24/24) methyltransferase, FxLD system
TIGR04363 (24/24) FxLD family lantipeptide
TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (24/24) Lantibiotic biosynthesis dehydratase C-term
PF05331 (24/24) Protein of unknown function (DUF742)
PF05147 (24/24) Lanthionine synthetase C-like protein
PF04738 (24/24) Lantibiotic dehydratase, N terminus
PF03259 (24/24) Roadblock/LC7 domain
PF03029 (24/24) Conserved hypothetical ATP binding protein
PF01135 (24/24) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (24/24) ABC transporter
PF02771 (23/24) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (23/24) Acyl-CoA dehydrogenase, middle domain
PF01590 (23/24) GAF domain
PF00441 (23/24) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (23/24) NUDIX domain
PF02518 (21/24) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00723 (19/24) Glycosyl hydrolases family 15
PF01427 (18/24) D-ala-D-ala dipeptidase
PF13649 (13/24) Methyltransferase domain
precursor_jaccard_groups_793 27.55 +- 17.15 2 0 0 0 0.21 +- 0.18 2 9

TIGR03802 (2/2) aspartate-alanine antiporter
TIGR03801 (2/2) aspartate 4-decarboxylase
PF06826 (2/2) Predicted Permease Membrane Region
PF02080 (2/2) TrkA-C domain
PF00155 (2/2) Aminotransferase class I and II
TIGR03356 (1/2) beta-galactosidase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00232 (1/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_45418 71.97 +- 1.42 2 0 0 0 0.14 +- 0.16 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_29418 192.32 +- 7.43 2 0 2 0 0.12 +- 0.31 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_20649 91.36 +- 15.97 3 0 0 0 0.06 +- 0.11 3 8

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF00717 (3/3) Peptidase S24-like
PF00501 (3/3) AMP-binding enzyme
PF00092 (3/3) von Willebrand factor type A domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_15957 242.84 +- 37.96 2 0 1 0 0.04 +- 0.02 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF07532 (1/2) Bacterial Ig-like domain (group 4)
PF00754 (1/2) F5/8 type C domain
precursor_jaccard_groups_19936 63.27 +- 4.03 2 0 0 0 0.10 +- 0.12 2 5

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF02655 (1/2) ATP-grasp domain
precursor_jaccard_groups_28413 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_8600 757.69 +- 655.20 5 0 5 0 0.04 +- 0.14 5 13

TIGR01733 (5/5) amino acid adenylation domain
TIGR00652 (5/5) diaminopimelate epimerase
PF14518 (5/5) Iron-containing redox enzyme
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10014 (5/5) 2OG-Fe dioxygenase
PF05977 (5/5) Transmembrane secretion effector
PF01678 (5/5) Diaminopimelate epimerase
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF03621 (4/5) MbtH-like protein
precursor_jaccard_groups_40115 34.95 +- 20.77 2 0 0 0 0.09 +- 0.10 2 2

PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_24164 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_20476 44.04 +- 22.54 2 0 2 0 0.13 +- 0.18 2 6

PF17920 (2/2) Tetracyclin repressor-like, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF01764 (1/2) Lipase (class 3)
PF00248 (1/2) Aldo/keto reductase family
precursor_jaccard_groups_774 148.78 +- 104.60 7 0 6 0 0.03 +- 0.02 7 3

PF09924 (7/7) Uncharacterised conserved protein (DUF2156)
PF07690 (7/7) Major Facilitator Superfamily
PF00487 (7/7) Fatty acid desaturase
precursor_jaccard_groups_30165 692.30 +- 210.70 2 0 0 0 0.01 +- 0.00 2 10

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (2/2) Methyltransferase domain
PF13570 (2/2) PQQ-like domain
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_38153 54.17 +- 0.00 2 0 0 0 0.11 +- 0.21 2 6

TIGR01806 (2/2) putative chorismate mutase
PF13808 (2/2) DDE_Tnp_1-associated
PF07730 (2/2) Histidine kinase
PF01817 (2/2) Chorismate mutase type II
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_770 41.30 +- 11.97 36 0 0 0 0.11 +- 0.10 36 5

TIGR00456 (36/36) arginine--tRNA ligase
PF05746 (36/36) DALR anticodon binding domain
PF03485 (36/36) Arginyl tRNA synthetase N terminal domain
PF00750 (36/36) tRNA synthetases class I (R)
PF00561 (36/36) alpha/beta hydrolase fold
precursor_jaccard_groups_24168 258.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_4232 20.57 +- 6.31 7 0 7 0 0.18 +- 0.23 7 6

PF13354 (7/7) Beta-lactamase enzyme family
PF03466 (7/7) LysR substrate binding domain
PF01380 (7/7) SIS domain
PF01116 (7/7) Fructose-bisphosphate aldolase class-II
PF00126 (7/7) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR00167 (6/7) ketose-bisphosphate aldolase
precursor_jaccard_groups_24945 242.62 +- 47.62 2 0 0 0 0.01 +- 0.01 2 3

PF01738 (2/2) Dienelactone hydrolase family
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_24760 194.50 +- 65.50 2 0 0 0 0.01 +- 0.00 2 5

TIGR03026 (2/2) nucleotide sugar dehydrogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_25149 265.88 +- 185.62 2 0 0 2 0.03 +- 0.05 2 4

PF13649 (2/2) Methyltransferase domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
precursor_jaccard_groups_179 53.11 +- 23.08 19 0 0 0 0.21 +- 0.23 19 9

TIGR03860 (19/19) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (19/19) FAD-NAD(P)-binding
PF07920 (19/19) Protein of unknown function (DUF1684)
PF00296 (19/19) Luciferase-like monooxygenase
PF02983 (18/19) Alpha-lytic protease prodomain
PF00089 (18/19) Trypsin
TIGR01726 (16/19) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (15/19) Binding-protein-dependent transport system inner membrane component
PF00005 (15/19) ABC transporter
precursor_jaccard_groups_40628 519.00 +- 261.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03989 (2/2) NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family
PF13459 (2/2) 4Fe-4S single cluster domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00067 (2/2) Cytochrome P450
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_20425 280.61 +- 235.39 2 0 0 0 0.11 +- 0.30 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
PF00067 (2/2) Cytochrome P450
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
precursor_jaccard_groups_172 133.61 +- 202.95 16 0 8 0 0.08 +- 0.14 16 5

TIGR01525 (16/16) heavy metal translocating P-type ATPase
PF04314 (16/16) Copper chaperone PCu(A)C
PF00702 (16/16) haloacid dehalogenase-like hydrolase
PF00403 (16/16) Heavy-metal-associated domain
PF00122 (16/16) E1-E2 ATPase
precursor_jaccard_groups_10899 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase
precursor_jaccard_groups_40757 25.03 +- 0.62 2 0 0 0 0.20 +- 0.24 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04909 (2/2) Amidohydrolase
PF01575 (2/2) MaoC like domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_1358 22.05 +- 6.49 22 0 6 0 0.19 +- 0.08 22 8

PF13377 (22/22) Periplasmic binding protein-like domain
PF12831 (22/22) FAD dependent oxidoreductase
PF07859 (22/22) alpha/beta hydrolase fold
PF06808 (22/22) Tripartite ATP-independent periplasmic transporter, DctM component
PF05378 (22/22) Hydantoinase/oxoprolinase N-terminal region
PF01968 (22/22) Hydantoinase/oxoprolinase
PF00356 (22/22) Bacterial regulatory proteins, lacI family
PF01636 (13/22) Phosphotransferase enzyme family
precursor_jaccard_groups_14603 26.80 +- 4.84 4 0 4 0 0.17 +- 0.31 4 10

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF17196 (4/4) Protein of unknown function (DUF5133)
PF13964 (4/4) Kelch motif
PF09118 (4/4) Domain of unknown function (DUF1929)
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF00135 (4/4) Carboxylesterase family
PF00005 (4/4) ABC transporter
PF00754 (3/4) F5/8 type C domain
PF13305 (2/4) Tetracyclin repressor-like, C-terminal domain
PF01381 (2/4) Helix-turn-helix
precursor_jaccard_groups_45072 453.50 +- 66.50 2 0 2 2 0.01 +- 0.00 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF05114 (2/2) Protein of unknown function (DUF692)
PF04303 (2/2) PrpF protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00881 (2/2) Nitroreductase family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00501 (1/2) AMP-binding enzyme
precursor_jaccard_groups_17972 56.57 +- 33.62 3 0 0 0 0.09 +- 0.06 3 6

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13649 (3/3) Methyltransferase domain
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF01794 (3/3) Ferric reductase like transmembrane component
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_6800 285.71 +- 10.10 3 0 3 3 0.02 +- 0.00 3 5

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07690 (3/3) Major Facilitator Superfamily
PF00881 (3/3) Nitroreductase family
precursor_jaccard_groups_13072 26.87 +- 2.68 2 0 2 0 0.11 +- 0.06 2 7

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
precursor_jaccard_groups_6805 38.23 +- 32.58 4 0 0 0 0.08 +- 0.12 4 5

TIGR00546 (4/4) apolipoprotein N-acyltransferase
PF13577 (4/4) SnoaL-like domain
PF01794 (4/4) Ferric reductase like transmembrane component
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00582 (4/4) Universal stress protein family
precursor_jaccard_groups_17401 236.50 +- 30.41 3 0 0 0 0.01 +- 0.00 3 4

PF13631 (3/3) Cytochrome b(N-terminal)/b6/petB
PF13466 (3/3) STAS domain
PF03861 (3/3) ANTAR domain
PF01590 (3/3) GAF domain
precursor_jaccard_groups_24891 38.53 +- 12.20 2 0 0 0 0.12 +- 0.10 2 9

PF18448 (2/2) Carbohydrate binding domain
PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF03442 (2/2) Carbohydrate binding domain X2
PF02449 (2/2) Beta-galactosidase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_30363 35.47 +- 3.22 2 0 0 0 0.14 +- 0.05 2 7

PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_25787 53.08 +- 4.70 2 0 0 0 0.08 +- 0.08 2 4

TIGR02547 (2/2) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
PF13649 (2/2) Methyltransferase domain
PF09481 (2/2) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
precursor_jaccard_groups_16892 118.50 +- 53.50 2 0 2 0 0.02 +- 0.02 2 2

PF05990 (2/2) Alpha/beta hydrolase of unknown function (DUF900)
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_24307 532.30 +- 265.64 2 0 2 0 0.12 +- 0.26 2 28

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
TIGR00223 (2/2) aspartate 1-decarboxylase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13847 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF13358 (2/2) DDE superfamily endonuclease
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF02261 (2/2) Aspartate decarboxylase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9042 4562.99 +- 1627.42 5 0 2 0 0.01 +- 0.03 5 10

PF17914 (5/5) HopA1 effector protein family
PF13649 (5/5) Methyltransferase domain
PF05193 (5/5) Peptidase M16 inactive domain
PF02441 (5/5) Flavoprotein
PF00675 (5/5) Insulinase (Peptidase family M16)
PF00664 (5/5) ABC transporter transmembrane region
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
PF01527 (4/5) Transposase
PF01061 (4/5) ABC-2 type transporter
precursor_jaccard_groups_31144 95.53 +- 3.39 2 0 0 0 0.10 +- 0.05 2 9

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01301 (2/2) Glycosyl hydrolases family 35
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF13377 (1/2) Periplasmic binding protein-like domain
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_43595 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_jaccard_groups_42508 61.28 +- 3.22 2 0 0 0 0.05 +- 0.03 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_43221 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08924 (2/2) Domain of unknown function (DUF1906)
PF06737 (2/2) Transglycosylase-like domain
precursor_jaccard_groups_34935 126.60 +- 27.03 2 0 0 0 0.11 +- 0.24 2 20

TIGR00678 (2/2) DNA polymerase III, delta' subunit
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF13177 (2/2) DNA polymerase III, delta subunit
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01522 (2/2) Polysaccharide deacetylase
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_40246 44.88 +- 0.65 2 0 0 0 0.07 +- 0.10 2 2

PF07690 (2/2) Major Facilitator Superfamily
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_3289 2331.00 +- 9.00 2 0 2 0 0.01 +- 0.00 2 4

PF01757 (2/2) Acyltransferase family
PF00664 (2/2) ABC transporter transmembrane region
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_34739 128.60 +- 0.40 2 0 0 0 0.16 +- 0.33 2 15

PF13473 (2/2) Cupredoxin-like domain
PF13462 (2/2) Thioredoxin
PF13386 (2/2) Cytochrome C biogenesis protein transmembrane region
PF11303 (2/2) Protein of unknown function (DUF3105)
PF11292 (2/2) Protein of unknown function (DUF3093)
PF09678 (2/2) Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PF09490 (2/2) Probable cobalt transporter subunit (CbtA)
PF09489 (2/2) Probable cobalt transporter subunit (CbtB)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF00484 (2/2) Carbonic anhydrase
PF00403 (2/2) Heavy-metal-associated domain
precursor_jaccard_groups_44613 91.60 +- 0.33 2 0 2 0 0.10 +- 0.29 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_44618 35.25 +- 5.48 2 0 0 0 0.06 +- 0.06 2 4

PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_3195 143.44 +- 114.56 2 0 2 0 0.04 +- 0.04 2 4

PF09265 (2/2) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01565 (2/2) FAD binding domain
precursor_jaccard_groups_3196 65.80 +- 23.63 11 0 2 0 0.14 +- 0.16 11 9

PF16896 (11/11) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (11/11) Major Facilitator Superfamily
PF03807 (11/11) NADP oxidoreductase coenzyme F420-dependent
PF02733 (11/11) Dak1 domain
PF01261 (11/11) Xylose isomerase-like TIM barrel
PF00121 (11/11) Triosephosphate isomerase
TIGR02133 (10/11) ribose 5-phosphate isomerase
PF02734 (10/11) DAK2 domain
PF02502 (10/11) Ribose/Galactose Isomerase
precursor_jaccard_groups_10412 12.27 +- 2.64 5 0 0 0 0.17 +- 0.10 5 6

PF14542 (5/5) GCN5-related N-acetyl-transferase
PF08220 (5/5) DeoR-like helix-turn-helix domain
PF02782 (5/5) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (5/5) DeoR C terminal sensor domain
PF00370 (5/5) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (5/5) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_2771 67.46 +- 13.85 10 0 0 0 0.14 +- 0.27 10 14

TIGR03796 (10/10) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR01389 (10/10) ATP-dependent DNA helicase RecQ
PF16124 (10/10) RecQ zinc-binding
PF09382 (10/10) RQC domain
PF03412 (10/10) Peptidase C39 family
PF00664 (10/10) ABC transporter transmembrane region
PF00570 (10/10) HRDC domain
PF00271 (10/10) Helicase conserved C-terminal domain
PF00270 (10/10) DEAD/DEAH box helicase
PF00005 (10/10) ABC transporter
TIGR03797 (9/10) NHLM bacteriocin system ABC transporter, ATP-binding protein
PF13437 (9/10) HlyD family secretion protein
PF13545 (7/10) Crp-like helix-turn-helix domain
PF00027 (7/10) Cyclic nucleotide-binding domain
precursor_jaccard_groups_3359 49.55 +- 24.60 10 0 0 0 0.05 +- 0.03 10 3

PF00150 (10/10) Cellulase (glycosyl hydrolase family 5)
PF09130 (9/10) Domain of unknown function (DUF1932)
PF03446 (7/10) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_10417 120.70 +- 72.67 5 0 5 0 0.02 +- 0.01 5 2

PF11575 (5/5) FhuF 2Fe-2S C-terminal domain
PF04616 (5/5) Glycosyl hydrolases family 43
precursor_jaccard_groups_10419 78.19 +- 0.44 2 0 0 0 0.10 +- 0.24 2 10

PF17668 (2/2) Acetyltransferase (GNAT) domain
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13530 (2/2) Sterol carrier protein domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12821 (2/2) Threonine/Serine exporter, ThrE
PF09335 (2/2) SNARE associated Golgi protein
PF06738 (2/2) Putative threonine/serine exporter
PF00877 (2/2) NlpC/P60 family
PF00183 (2/2) Hsp90 protein
precursor_jaccard_groups_3354 233.04 +- 195.01 7 0 6 0 0.05 +- 0.06 7 7

PF12728 (7/7) Helix-turn-helix domain
PF08402 (7/7) TOBE domain
PF03459 (7/7) TOBE domain
PF00005 (7/7) ABC transporter
PF13343 (6/7) Bacterial extracellular solute-binding protein
PF00528 (6/7) Binding-protein-dependent transport system inner membrane component
PF06236 (5/7) Tyrosinase co-factor MelC1
precursor_jaccard_groups_44856 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_18363 134.45 +- 23.20 3 0 3 0 0.08 +- 0.11 3 12

TIGR04498 (3/3) abortive infection protein, AbiV family
PF18728 (3/3) AbiV
PF03711 (3/3) Orn/Lys/Arg decarboxylase, C-terminal domain
PF03709 (3/3) Orn/Lys/Arg decarboxylase, N-terminal domain
PF02371 (3/3) Transposase IS116/IS110/IS902 family
PF01609 (3/3) Transposase DDE domain
PF01548 (3/3) Transposase
PF01276 (3/3) Orn/Lys/Arg decarboxylase, major domain
PF00494 (3/3) Squalene/phytoene synthase
PF00348 (3/3) Polyprenyl synthetase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_44859 152.37 +- 21.19 2 0 2 2 0.11 +- 0.16 2 12

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01613 (2/2) Flavin reductase like domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_2563 20.95 +- 7.27 2 0 0 0 0.17 +- 0.18 2 7

PF13560 (2/2) Helix-turn-helix domain
PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12867 (2/2) DinB superfamily
PF07690 (2/2) Major Facilitator Superfamily
PF04149 (2/2) Domain of unknown function (DUF397)
PF00089 (2/2) Trypsin
precursor_jaccard_groups_34641 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_42264 130.00 +- 70.00 2 0 0 0 0.04 +- 0.03 2 6

PF12833 (2/2) Helix-turn-helix domain
PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/2) mttA/Hcf106 family
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_35063 185.29 +- 74.71 2 0 2 0 0.01 +- 0.01 2 3

PF02195 (2/2) ParB-like nuclease domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
precursor_jaccard_groups_31707 173.00 +- 87.00 2 0 0 0 0.02 +- 0.03 2 4

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_23789 226.51 +- 44.39 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_7517 9.43 +- 0.38 2 0 2 0 0.21 +- 0.01 2 5

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
precursor_jaccard_groups_31701 59.24 +- 5.76 2 0 2 0 0.14 +- 0.21 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09997 (2/2) Predicted membrane protein (DUF2238)
PF07690 (2/2) Major Facilitator Superfamily
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40228 9.08 +- 0.06 2 0 2 0 0.22 +- 0.39 2 4

PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
PF00089 (2/2) Trypsin
precursor_jaccard_groups_7299 33.12 +- 2.47 2 0 0 0 0.20 +- 0.25 2 10

TIGR00198 (2/2) catalase/peroxidase HPI
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03777 (2/2) ChpA-C
PF02515 (2/2) CoA-transferase family III
PF01475 (2/2) Ferric uptake regulator family
PF00561 (2/2) alpha/beta hydrolase fold
PF00501 (2/2) AMP-binding enzyme
PF00141 (2/2) Peroxidase
PF00069 (2/2) Protein kinase domain
PF03358 (1/2) NADPH-dependent FMN reductase
precursor_jaccard_groups_44100 181.69 +- 108.56 2 0 2 0 0.03 +- 0.03 2 4

PF13378 (2/2) Enolase C-terminal domain-like
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
precursor_jaccard_groups_13260 194.17 +- 27.47 4 0 4 0 0.15 +- 0.29 4 27

TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01426 (4/4) glycosyltransferase, MGT family
TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (4/4) Domain of unknown function (DUF4162)
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF12697 (4/4) Alpha/beta hydrolase family
PF07977 (4/4) FabA-like domain
PF03109 (4/4) ABC1 family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02635 (4/4) DsrE/DsrF-like family
PF01593 (4/4) Flavin containing amine oxidoreductase
PF01323 (4/4) DSBA-like thioredoxin domain
PF01061 (4/4) ABC-2 type transporter
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
TIGR01720 (3/4) non-ribosomal peptide synthase domain TIGR01720
TIGR00747 (3/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (3/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
precursor_jaccard_groups_5448 175.33 +- 70.33 8 0 0 0 0.11 +- 0.11 8 17

TIGR01409 (8/8) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (8/8) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (8/8) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (8/8) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (8/8) Alpha galactosidase A
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13378 (8/8) Enolase C-terminal domain-like
PF08450 (8/8) SMP-30/Gluconolactonase/LRE-like region
PF07729 (8/8) FCD domain
PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (8/8) Melibiase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01081 (8/8) KDPG and KHG aldolase
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
precursor_jaccard_groups_39577 995.76 +- 386.38 2 0 2 0 0.02 +- 0.01 2 24

TIGR01733 (2/2) amino acid adenylation domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF14518 (2/2) Iron-containing redox enzyme
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF03417 (2/2) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01266 (2/2) FAD dependent oxidoreductase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_10529 226.48 +- 96.16 5 0 0 0 0.01 +- 0.01 5 3

TIGR01426 (5/5) glycosyltransferase, MGT family
PF03372 (5/5) Endonuclease/Exonuclease/phosphatase family
PF00201 (5/5) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_37347 51.53 +- 29.25 2 0 0 0 0.12 +- 0.20 2 5

PF14435 (2/2) SUKH-4 immunity protein
PF07690 (2/2) Major Facilitator Superfamily
PF01872 (2/2) RibD C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01206 (2/2) Sulfurtransferase TusA
precursor_jaccard_groups_10521 611.83 +- 229.98 5 0 0 0 0.01 +- 0.01 5 11

TIGR01490 (5/5) HAD hydrolase, family IB
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF05655 (4/5) Pseudomonas avirulence D protein (AvrD)
PF01648 (4/5) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/5) Thioesterase domain
PF00550 (4/5) Phosphopantetheine attachment site
precursor_jaccard_groups_14574 229.35 +- 53.17 4 0 0 0 0.02 +- 0.01 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF00455 (4/4) DeoR C terminal sensor domain
PF00359 (4/4) Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PF00027 (4/4) Cyclic nucleotide-binding domain
precursor_jaccard_groups_14577 277.50 +- 293.57 4 0 0 0 0.02 +- 0.04 4 9

TIGR01167 (4/4) LPXTG cell wall anchor domain
PF17802 (4/4) Prealbumin-like fold domain
PF13535 (4/4) ATP-grasp domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01555 (4/4) DNA methylase
PF00746 (4/4) LPXTG cell wall anchor motif
PF16259 (3/4) Domain of unknown function (DUF4913)
PF01638 (3/4) HxlR-like helix-turn-helix
precursor_jaccard_groups_5722 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_1852 36.49 +- 24.16 18 0 1 0 0.10 +- 0.14 18 3

PF13649 (18/18) Methyltransferase domain
PF00484 (18/18) Carbonic anhydrase
PF00916 (13/18) Sulfate permease family
precursor_jaccard_groups_43912 120.74 +- 20.74 2 0 0 0 0.08 +- 0.11 2 14

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
PF13613 (1/2) Helix-turn-helix of DDE superfamily endonuclease
PF04828 (1/2) Glutathione-dependent formaldehyde-activating enzyme
PF01609 (1/2) Transposase DDE domain
precursor_jaccard_groups_31367 125.00 +- 47.00 2 0 0 0 0.03 +- 0.04 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_32499 416.77 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04909 (2/2) Amidohydrolase
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_31361 31.47 +- 5.98 2 0 0 0 0.08 +- 0.08 2 6

PF17269 (2/2) Family of unknown function (DUF5335)
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF00753 (2/2) Metallo-beta-lactamase superfamily
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_946 509.90 +- 467.37 29 0 28 28 0.04 +- 0.10 29 6

PF00664 (29/29) ABC transporter transmembrane region
PF00326 (29/29) Prolyl oligopeptidase family
PF00005 (29/29) ABC transporter
PF05147 (28/29) Lanthionine synthetase C-like protein
PF04672 (28/29) S-adenosyl methyltransferase
PF00069 (28/29) Protein kinase domain
precursor_jaccard_groups_35607 32.50 +- 0.00 2 0 0 0 0.12 +- 0.10 2 8

TIGR01695 (2/2) murein biosynthesis integral membrane protein MurJ
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03023 (2/2) Lipid II flippase MurJ
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_39599 390.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 6

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_31560 435.50 +- 84.50 2 0 0 0 0.02 +- 0.02 2 5

PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03640 (2/2) Secreted repeat of unknown function
PF14246 (1/2) AefR-like transcriptional repressor, C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_31566 78.41 +- 20.21 2 0 0 0 0.14 +- 0.20 2 11

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04978 (2/2) Protein of unknown function (DUF664)
PF01590 (2/2) GAF domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF18029 (1/2) Glyoxalase-like domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00872 (1/2) Transposase, Mutator family
precursor_jaccard_groups_35266 107.56 +- 6.94 2 0 2 0 0.13 +- 0.23 2 12

PF13924 (2/2) Lipocalin-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04673 (2/2) Polyketide synthesis cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF17754 (1/2) MftR C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_18473 332.14 +- 118.84 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family
precursor_jaccard_groups_18474 112.46 +- 23.39 3 0 0 0 0.02 +- 0.01 3 3

PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF04229 (3/3) GrpB protein
PF01979 (3/3) Amidohydrolase family
precursor_jaccard_groups_39115 137.83 +- 64.11 2 0 0 0 0.12 +- 0.10 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13523 (2/2) Acetyltransferase (GNAT) domain
PF06172 (2/2) Cupin superfamily (DUF985)
PF05425 (2/2) Copper resistance protein D
PF04234 (2/2) CopC domain
PF01804 (2/2) Penicillin amidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_14171 1154.22 +- 602.60 4 0 0 0 0.02 +- 0.03 4 5

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
precursor_jaccard_groups_570 203.67 +- 151.60 22 0 21 22 0.04 +- 0.10 22 4

TIGR03891 (22/22) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (21/22) Lantibiotic biosynthesis dehydratase C-term
PF05147 (21/22) Lanthionine synthetase C-like protein
PF04738 (19/22) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_38975 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
precursor_jaccard_groups_38974 419.50 +- 204.50 2 0 0 0 0.02 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
PF13546 (1/2) DDE superfamily endonuclease
precursor_jaccard_groups_10666 23.23 +- 6.42 5 0 0 0 0.09 +- 0.12 5 3

PF11203 (5/5) Putative type VII ESX secretion system translocon, EccE
PF00877 (5/5) NlpC/P60 family
PF02195 (4/5) ParB-like nuclease domain
precursor_jaccard_groups_24433 234.00 +- 26.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06259 (2/2) Alpha/beta hydrolase
precursor_jaccard_groups_18564 394.26 +- 108.83 3 0 0 0 0.05 +- 0.15 3 12

PF13814 (3/3) Replication-relaxation
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF12846 (3/3) AAA-like domain
PF12642 (3/3) Conjugative transposon protein TcpC
PF08666 (3/3) SAF domain
PF07811 (3/3) TadE-like protein
PF01476 (3/3) LysM domain
PF00877 (3/3) NlpC/P60 family
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF13406 (2/3) Transglycosylase SLT domain
PF10935 (2/3) Protein of unknown function (DUF2637)
precursor_jaccard_groups_16973 36.17 +- 17.87 3 0 0 0 0.09 +- 0.12 3 3

PF06609 (3/3) Fungal trichothecene efflux pump (TRI12)
PF01656 (3/3) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01234 (3/3) NNMT/PNMT/TEMT family
precursor_jaccard_groups_10669 18.98 +- 4.73 4 0 0 0 0.16 +- 0.10 4 2

PF11575 (4/4) FhuF 2Fe-2S C-terminal domain
PF01794 (4/4) Ferric reductase like transmembrane component
precursor_jaccard_groups_2398 1038.26 +- 232.64 15 0 7 15 0.01 +- 0.01 15 6

TIGR04085 (15/15) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (15/15) Iron-sulfur cluster-binding domain
PF05402 (15/15) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (15/15) Radical SAM superfamily
PF01061 (15/15) ABC-2 type transporter
PF00005 (15/15) ABC transporter
precursor_jaccard_groups_11424 120.34 +- 103.15 3 0 0 0 0.07 +- 0.21 3 7

TIGR00498 (3/3) repressor LexA
PF11799 (3/3) impB/mucB/samB family C-terminal domain
PF01726 (3/3) LexA DNA binding domain
PF00717 (3/3) Peptidase S24-like
PF17657 (2/3) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/3) Helix-hairpin-helix motif
PF07733 (2/3) Bacterial DNA polymerase III alpha NTPase domain
precursor_jaccard_groups_14312 1421.75 +- 4.76 4 0 4 0 0.01 +- 0.00 4 7

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08028 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (4/4) Condensation domain
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_9094 356.58 +- 209.63 4 0 3 0 0.03 +- 0.06 4 6

PF17827 (4/4) PrmC N-terminal domain
PF13649 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01266 (4/4) FAD dependent oxidoreductase
PF00440 (3/4) Bacterial regulatory proteins, tetR family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_18659 212.05 +- 177.95 2 0 2 0 0.06 +- 0.14 2 9

TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (2/2) Glycosyl transferases group 1
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13439 (2/2) Glycosyltransferase Family 4
PF04932 (2/2) O-Antigen ligase
PF03023 (2/2) Lipid II flippase MurJ
PF02397 (2/2) Bacterial sugar transferase
PF01522 (2/2) Polysaccharide deacetylase
PF00534 (1/2) Glycosyl transferases group 1
precursor_jaccard_groups_33637 182.76 +- 33.91 2 0 0 0 0.02 +- 0.01 2 7

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
TIGR01451 (2/2) conserved repeat domain
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13489 (2/2) Methyltransferase domain
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF01345 (2/2) Domain of unknown function DUF11
precursor_jaccard_groups_19782 60.75 +- 34.52 3 0 0 0 0.09 +- 0.06 3 5

PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (3/3) Saccharopine dehydrogenase NADP binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01266 (3/3) FAD dependent oxidoreductase
precursor_jaccard_groups_38627 42.67 +- 14.67 2 0 0 0 0.11 +- 0.18 2 5

PF16670 (2/2) Phosphoinositide phospholipase C, Ca2+-dependent
PF13751 (2/2) Transposase DDE domain
PF13655 (2/2) N-terminal domain of reverse transcriptase
PF03795 (2/2) YCII-related domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_jaccard_groups_33633 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 4

PF14907 (2/2) Uncharacterised nucleotidyltransferase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00696 (2/2) Amino acid kinase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_32725 17.36 +- 3.91 2 0 0 0 0.18 +- 0.05 2 6

PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_9560 21.79 +- 4.26 5 0 0 0 0.09 +- 0.12 5 3

PF14016 (5/5) Protein of unknown function (DUF4232)
PF10604 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF07859 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_4506 148.12 +- 97.30 7 0 0 0 0.11 +- 0.20 7 12

TIGR01764 (7/7) DNA binding domain, excisionase family
PF13245 (7/7) AAA domain
PF12728 (7/7) Helix-turn-helix domain
PF12697 (7/7) Alpha/beta hydrolase family
PF12679 (7/7) ABC-2 family transporter protein
PF03033 (7/7) Glycosyltransferase family 28 N-terminal domain
PF01551 (7/7) Peptidase family M23
PF00392 (7/7) Bacterial regulatory proteins, gntR family
PF00005 (7/7) ABC transporter
PF13673 (4/7) Acetyltransferase (GNAT) domain
PF13411 (4/7) MerR HTH family regulatory protein
PF07739 (4/7) TipAS antibiotic-recognition domain
precursor_jaccard_groups_4507 77.22 +- 52.18 5 0 0 0 0.08 +- 0.03 5 10

PF17801 (5/5) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (5/5) Alpha galactosidase A
PF07995 (5/5) Glucose / Sorbosone dehydrogenase
PF07470 (5/5) Glycosyl Hydrolase Family 88
PF03422 (5/5) Carbohydrate binding module (family 6)
PF01120 (5/5) Alpha-L-fucosidase
PF00754 (5/5) F5/8 type C domain
PF14099 (4/5) Polysaccharide lyase
PF00704 (4/5) Glycosyl hydrolases family 18
PF00041 (4/5) Fibronectin type III domain
precursor_jaccard_groups_2951 247.18 +- 268.40 3 0 0 0 0.04 +- 0.04 3 4

PF07702 (3/3) UTRA domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF13546 (2/3) DDE superfamily endonuclease
precursor_jaccard_groups_18309 62.47 +- 18.15 2 0 0 0 0.05 +- 0.07 2 6

PF14100 (2/2) Methane oxygenase PmoA
PF13229 (2/2) Right handed beta helix region
PF07602 (2/2) Protein of unknown function (DUF1565)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_1450 162.97 +- 221.92 20 0 5 16 0.14 +- 0.18 20 18

TIGR01525 (20/20) heavy metal translocating P-type ATPase
PF04314 (20/20) Copper chaperone PCu(A)C
PF00702 (20/20) haloacid dehalogenase-like hydrolase
PF00403 (20/20) Heavy-metal-associated domain
PF00122 (20/20) E1-E2 ATPase
TIGR02937 (19/20) RNA polymerase sigma factor, sigma-70 family
PF08281 (19/20) Sigma-70, region 4
PF04542 (19/20) Sigma-70 region 2
PF01497 (19/20) Periplasmic binding protein
PF01032 (19/20) FecCD transport family
PF00005 (19/20) ABC transporter
PF00733 (16/20) Asparagine synthase
TIGR01536 (15/20) asparagine synthase (glutamine-hydrolyzing)
PF13537 (15/20) Glutamine amidotransferase domain
PF00067 (15/20) Cytochrome P450
PF06197 (14/20) Protein of unknown function (DUF998)
PF05141 (13/20) Pyoverdine/dityrosine biosynthesis protein
PF07690 (12/20) Major Facilitator Superfamily
precursor_jaccard_groups_1457 114.09 +- 14.61 26 0 26 0 0.10 +- 0.23 26 15

PF13822 (26/26) Acyl-CoA carboxylase epsilon subunit
PF13561 (26/26) Enoyl-(Acyl carrier protein) reductase
PF13459 (26/26) 4Fe-4S single cluster domain
PF08031 (26/26) Berberine and berberine like
PF03704 (26/26) Bacterial transcriptional activator domain
PF01648 (26/26) 4'-phosphopantetheinyl transferase superfamily
PF01565 (26/26) FAD binding domain
PF01494 (26/26) FAD binding domain
PF01039 (26/26) Carboxyl transferase domain
PF00975 (26/26) Thioesterase domain
PF00583 (26/26) Acetyltransferase (GNAT) family
PF00550 (26/26) Phosphopantetheine attachment site
PF00486 (26/26) Transcriptional regulatory protein, C terminal
PF00067 (26/26) Cytochrome P450
PF10604 (25/26) Polyketide cyclase / dehydrase and lipid transport
precursor_jaccard_groups_41411 325.00 +- 65.00 2 0 2 2 0.01 +- 0.00 2 5

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_10796 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_jaccard_groups_13444 673.65 +- 236.08 4 0 0 0 0.02 +- 0.05 4 16

PF18448 (4/4) Carbohydrate binding domain
PF17851 (4/4) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (4/4) Domain of unknown function(DUF4981)
PF14310 (4/4) Fibronectin type III-like domain
PF04616 (4/4) Glycosyl hydrolases family 43
PF03442 (4/4) Carbohydrate binding domain X2
PF03422 (4/4) Carbohydrate binding module (family 6)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (4/4) Alpha-L-fucosidase
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF15902 (3/4) Sortilin, neurotensin receptor 3,
PF14200 (3/4) Ricin-type beta-trefoil lectin domain-like
precursor_jaccard_groups_39751 351.00 +- 39.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_8949 270.68 +- 245.32 2 0 2 0 0.08 +- 0.13 2 7

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_31965 216.67 +- 43.33 2 0 2 0 0.01 +- 0.00 2 3

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_31964 18.22 +- 0.89 2 0 0 0 0.11 +- 0.02 2 2

PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (2/2) Dehydratase family
precursor_jaccard_groups_1929 53.78 +- 13.13 9 0 0 0 0.19 +- 0.16 9 8

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF13343 (9/9) Bacterial extracellular solute-binding protein
PF08402 (9/9) TOBE domain
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00005 (9/9) ABC transporter
PF03372 (8/9) Endonuclease/Exonuclease/phosphatase family
PF07690 (7/9) Major Facilitator Superfamily
precursor_jaccard_groups_23013 39.58 +- 17.56 2 0 1 0 0.11 +- 0.08 2 7

PF14361 (2/2) RsbT co-antagonist protein rsbRD N-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01740 (2/2) STAS domain
PF01645 (2/2) Conserved region in glutamate synthase
PF13411 (1/2) MerR HTH family regulatory protein
PF02627 (1/2) Carboxymuconolactone decarboxylase family
precursor_jaccard_groups_27205 104.00 +- 0.00 2 0 0 0 0.02 +- 0.01 2 4

PF13602 (2/2) Zinc-binding dehydrogenase
PF11706 (2/2) CGNR zinc finger
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07336 (2/2) Putative stress-induced transcription regulator
precursor_jaccard_groups_23015 135.41 +- 41.08 3 0 2 0 0.02 +- 0.02 3 5

PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00975 (3/3) Thioesterase domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_15132 79.71 +- 24.12 3 0 0 0 0.14 +- 0.07 3 7

PF13378 (3/3) Enolase C-terminal domain-like
PF04203 (3/3) Sortase domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF14344 (2/3) Domain of unknown function (DUF4397)
precursor_jaccard_groups_15423 197.27 +- 99.87 3 0 0 0 0.09 +- 0.19 3 9

TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01428 (3/3) haloacid dehalogenase, type II
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_36005 106.72 +- 48.08 2 0 2 0 0.06 +- 0.06 2 9

TIGR01686 (2/2) FkbH domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01596 (2/2) O-methyltransferase
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_4430 17.97 +- 2.84 6 0 0 0 0.18 +- 0.36 6 9

TIGR00229 (6/6) PAS domain S-box protein
PF13581 (6/6) Histidine kinase-like ATPase domain
PF12840 (6/6) Helix-turn-helix domain
PF08448 (6/6) PAS fold
PF07702 (6/6) UTRA domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00989 (6/6) PAS fold
PF00392 (6/6) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_33526 114.26 +- 40.54 2 0 0 0 0.02 +- 0.02 2 3

PF06172 (2/2) Cupin superfamily (DUF985)
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF13564 (1/2) DoxX-like family
precursor_jaccard_groups_5124 9.58 +- 1.75 4 0 0 0 0.21 +- 0.06 4 5

PF07676 (4/4) WD40-like Beta Propeller Repeat
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01979 (4/4) Amidohydrolase family
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_5122 432.00 +- 121.63 3 0 0 3 0.01 +- 0.00 3 3

TIGR00702 (3/3) YcaO-type kinase domain
PF07812 (3/3) TfuA-like protein
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_jaccard_groups_13000 25.59 +- 0.41 2 0 0 0 0.08 +- 0.07 2 5

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13641 (2/2) Glycosyltransferase like family 2
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF01522 (2/2) Polysaccharide deacetylase
PF01266 (2/2) FAD dependent oxidoreductase
precursor_jaccard_groups_37026 115.44 +- 5.97 2 0 0 0 0.03 +- 0.04 2 5

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_38717 62.30 +- 4.94 2 0 0 0 0.15 +- 0.15 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_jaccard_groups_8540 269.86 +- 86.45 5 0 5 0 0.02 +- 0.01 5 8

TIGR00517 (5/5) acyl carrier protein
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_12335 118.60 +- 67.91 2 0 0 0 0.15 +- 0.19 2 10

PF13407 (2/2) Periplasmic binding protein domain
PF03060 (2/2) Nitronate monooxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
precursor_jaccard_groups_8547 252.69 +- 211.44 3 0 0 0 0.09 +- 0.14 3 7

PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF02449 (3/3) Beta-galactosidase
PF01670 (3/3) Glycosyl hydrolase family 12
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_27841 391.19 +- 95.33 2 0 0 0 0.03 +- 0.05 2 10

TIGR03356 (2/2) beta-galactosidase
PF13802 (2/2) Galactose mutarotase-like
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF02449 (2/2) Beta-galactosidase
PF01670 (2/2) Glycosyl hydrolase family 12
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_33030 39.07 +- 5.52 2 0 0 0 0.11 +- 0.16 2 7

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF13560 (2/2) Helix-turn-helix domain
PF13520 (2/2) Amino acid permease
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07883 (2/2) Cupin domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00854 (2/2) POT family
precursor_jaccard_groups_18092 52.56 +- 3.75 3 0 0 0 0.08 +- 0.08 3 5

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF10990 (3/3) Protein of unknown function (DUF2809)
PF07681 (3/3) DoxX
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_6490 720.73 +- 236.74 7 0 7 7 0.01 +- 0.01 7 12

TIGR00730 (7/7) TIGR00730 family protein
PF14833 (7/7) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (7/7) Glutamine amidotransferase domain
PF13480 (7/7) Acetyltransferase (GNAT) domain
PF07690 (7/7) Major Facilitator Superfamily
PF03641 (7/7) Possible lysine decarboxylase
PF03446 (7/7) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (7/7) N-terminal domain of galactosyltransferase
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (7/7) Asparagine synthase
PF00535 (7/7) Glycosyl transferase family 2
PF00300 (7/7) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_22124 85.68 +- 34.77 2 0 2 0 0.16 +- 0.30 2 14

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR03086 (1/2) TIGR03086 family protein
TIGR00765 (1/2) YihY family inner membrane protein
PF13411 (1/2) MerR HTH family regulatory protein
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03631 (1/2) Virulence factor BrkB
precursor_jaccard_groups_11332 49.23 +- 4.32 4 0 4 0 0.08 +- 0.13 4 6

PF13243 (4/4) Squalene-hopene cyclase C-terminal domain
PF00754 (4/4) F5/8 type C domain
PF00432 (4/4) Prenyltransferase and squalene oxidase repeat
PF00067 (4/4) Cytochrome P450
TIGR03356 (3/4) beta-galactosidase
PF00232 (3/4) Glycosyl hydrolase family 1
precursor_jaccard_groups_36392 21.80 +- 7.09 2 0 2 0 0.10 +- 0.08 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13427 (2/2) Domain of unknown function (DUF4111)
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01909 (2/2) Nucleotidyltransferase domain
precursor_jaccard_groups_16526 241.98 +- 107.49 3 0 0 0 0.03 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_3258 12.07 +- 2.79 2 0 2 0 0.17 +- 0.21 2 4

PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF13520 (1/2) Amino acid permease
PF00324 (1/2) Amino acid permease
precursor_jaccard_groups_10247 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_jaccard_groups_10246 549.28 +- 205.94 3 0 0 0 0.01 +- 0.01 3 13

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03925 (3/3) type VII secretion protein EccCb
TIGR03924 (3/3) type VII secretion protein EccCa
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF17866 (3/3) AAA lid domain
PF13229 (3/3) Right handed beta helix region
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
PF01580 (3/3) FtsK/SpoIIIE family
PF00004 (3/3) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_1631 21.32 +- 7.84 9 0 0 0 0.16 +- 0.22 9 5

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF11361 (9/9) Protein of unknown function (DUF3159)
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (9/9) Polysaccharide deacetylase
PF08530 (7/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
precursor_jaccard_groups_37731 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_36139 2680.76 +- 157.24 2 0 2 0 0.01 +- 0.00 2 16

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10067 (2/2) Predicted membrane protein (DUF2306)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01757 (2/2) Acyltransferase family
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_12792 66.00 +- 10.61 4 0 0 0 0.20 +- 0.24 4 20

TIGR01374 (4/4) sarcosine oxidase, delta subunit family
TIGR01373 (4/4) sarcosine oxidase, beta subunit family
TIGR01186 (4/4) glycine betaine/L-proline transport ATP binding subunit
PF17806 (4/4) Sarcosine oxidase A3 domain
PF16350 (4/4) FAD dependent oxidoreductase central domain
PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (4/4) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (4/4) Sarcosine oxidase, gamma subunit family
PF04267 (4/4) Sarcosine oxidase, delta subunit family
PF04069 (4/4) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (4/4) Aminomethyltransferase folate-binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00464 (4/4) Serine hydroxymethyltransferase
PF00171 (4/4) Aldehyde dehydrogenase family
PF00144 (4/4) Beta-lactamase
PF00005 (4/4) ABC transporter
PF02882 (3/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (3/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_jaccard_groups_9969 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_36135 135.74 +- 37.59 2 0 0 0 0.04 +- 0.03 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF01596 (2/2) O-methyltransferase
PF01402 (2/2) Ribbon-helix-helix protein, copG family
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00072 (2/2) Response regulator receiver domain
TIGR00027 (1/2) methyltransferase, TIGR00027 family
PF04072 (1/2) Leucine carboxyl methyltransferase
precursor_jaccard_groups_41342 880.52 +- 76.75 2 0 2 0 0.01 +- 0.00 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_22490 517.33 +- 1.89 3 0 0 0 0.01 +- 0.00 3 6

PF09339 (3/3) IclR helix-turn-helix domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF02515 (3/3) CoA-transferase family III
PF01614 (3/3) Bacterial transcriptional regulator
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_22497 308.00 +- 111.72 3 0 3 0 0.01 +- 0.01 3 3

PF05401 (3/3) Nodulation protein S (NodS)
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_33450 105.07 +- 2.91 2 0 1 0 0.16 +- 0.26 2 18

PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07729 (2/2) FCD domain
PF05544 (2/2) Proline racemase
PF05195 (2/2) Aminopeptidase P, N-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00557 (2/2) Metallopeptidase family M24
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13808 (1/2) DDE_Tnp_1-associated
precursor_jaccard_groups_30429 91.64 +- 35.99 2 0 2 0 0.11 +- 0.23 2 23

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13535 (2/2) ATP-grasp domain
PF13444 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13185 (2/2) GAF domain
PF09335 (2/2) SNARE associated Golgi protein
PF08544 (2/2) GHMP kinases C terminal
PF08447 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01553 (2/2) Acyltransferase
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00206 (2/2) Lyase
PF02274 (1/2) Amidinotransferase
precursor_jaccard_groups_30428 82.79 +- 47.21 2 0 2 0 0.04 +- 0.02 2 4

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (2/2) FMN-dependent dehydrogenase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_7089 100.26 +- 53.04 6 0 6 0 0.07 +- 0.04 6 11

TIGR01733 (6/6) amino acid adenylation domain
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF00698 (6/6) Acyl transferase domain
PF00668 (6/6) Condensation domain
PF00551 (6/6) Formyl transferase
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_19321 38.21 +- 6.71 3 0 3 0 0.05 +- 0.05 3 3

TIGR02353 (3/3) non-ribosomal peptide synthetase terminal domain of unknown function
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00550 (3/3) Phosphopantetheine attachment site
precursor_jaccard_groups_1146 453.32 +- 357.50 25 0 25 25 0.02 +- 0.02 25 4

PF13471 (25/25) Transglutaminase-like superfamily
PF00733 (25/25) Asparagine synthase
PF00005 (25/25) ABC transporter
PF01546 (13/25) Peptidase family M20/M25/M40
precursor_jaccard_groups_22303 157.89 +- 72.87 3 0 0 0 0.02 +- 0.01 3 2

PF07730 (3/3) Histidine kinase
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_30800 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_39975 454.06 +- 20.72 2 0 2 0 0.02 +- 0.02 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_872 27.08 +- 12.12 19 0 0 0 0.15 +- 0.30 19 9

PF07714 (19/19) Protein tyrosine kinase
PF06723 (19/19) MreB/Mbl protein
PF03704 (19/19) Bacterial transcriptional activator domain
PF13185 (17/19) GAF domain
PF07730 (17/19) Histidine kinase
PF07728 (17/19) AAA domain (dynein-related subfamily)
PF03861 (15/19) ANTAR domain
PF13365 (14/19) Trypsin-like peptidase domain
PF13466 (11/19) STAS domain
precursor_jaccard_groups_6569 9.99 +- 2.31 3 0 0 0 0.23 +- 0.35 3 9

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (3/3) YD repeat (two copies)
TIGR00234 (3/3) tyrosine--tRNA ligase
PF07179 (3/3) SseB protein N-terminal domain
PF05593 (3/3) RHS Repeat
PF04149 (3/3) Domain of unknown function (DUF397)
PF01523 (3/3) Putative modulator of DNA gyrase
PF00579 (3/3) tRNA synthetases class I (W and Y)
PF13560 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_10333 411.72 +- 250.74 3 0 0 0 0.03 +- 0.12 3 8

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF03319 (3/3) Ethanolamine utilisation protein EutN/carboxysome
PF01636 (3/3) Phosphotransferase enzyme family
PF00936 (3/3) BMC domain
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
PF07702 (2/3) UTRA domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_27539 217.92 +- 132.08 2 0 0 0 0.04 +- 0.09 2 9

PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07681 (2/2) DoxX
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_26003 32.08 +- 3.81 2 0 0 0 0.16 +- 0.17 2 9

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF03625 (2/2) Domain of unknown function DUF302
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_22017 189.10 +- 128.56 3 0 0 0 0.09 +- 0.22 3 8

PF16884 (3/3) N-terminal domain of oxidoreductase
PF12146 (3/3) Serine aminopeptidase, S33
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/3) Major Facilitator Superfamily
precursor_jaccard_groups_22016 208.61 +- 126.14 3 0 3 0 0.05 +- 0.09 3 6

TIGR03930 (3/3) WXG100 family type VII secretion target
PF06013 (3/3) Proteins of 100 residues with WXG
PF00082 (3/3) Subtilase family
TIGR03921 (2/3) type VII secretion-associated serine protease mycosin
TIGR03919 (2/3) type VII secretion protein EccB
PF05108 (2/3) Type VII secretion system ESX-1, transport TM domain B
precursor_jaccard_groups_41746 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_43325 9.45 +- 0.47 2 0 2 0 0.21 +- 0.33 2 11

PF18369 (2/2) Polyketide synthase dimerisation element domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01039 (2/2) Carboxyl transferase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_8327 192.40 +- 85.37 6 0 0 0 0.02 +- 0.03 6 7

TIGR03930 (6/6) WXG100 family type VII secretion target
TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF06013 (6/6) Proteins of 100 residues with WXG
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/6) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_26796 206.40 +- 51.60 2 0 1 0 0.01 +- 0.01 2 3

PF01596 (2/2) O-methyltransferase
PF01474 (2/2) Class-II DAHP synthetase family
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
precursor_jaccard_groups_4727 235.76 +- 62.46 9 0 1 0 0.12 +- 0.28 9 12

TIGR01727 (9/9) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13385 (9/9) Concanavalin A-like lectin/glucanases superfamily
PF13088 (9/9) BNR repeat-like domain
PF12911 (9/9) N-terminal TM domain of oligopeptide transport permease C
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF02446 (9/9) 4-alpha-glucanotransferase
PF01120 (9/9) Alpha-L-fucosidase
PF00884 (9/9) Sulfatase
PF00701 (9/9) Dihydrodipicolinate synthetase family
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (9/9) ABC transporter
precursor_jaccard_groups_11203 1427.00 +- 223.49 4 0 0 0 0.01 +- 0.00 4 7

PF13480 (4/4) Acetyltransferase (GNAT) domain
PF08892 (4/4) YqcI/YcgG family
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF01725 (4/4) Ham1 family
PF00590 (4/4) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_30554 210.26 +- 3.86 2 0 0 0 0.04 +- 0.06 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_30881 68.53 +- 4.03 2 0 0 0 0.04 +- 0.03 2 5

PF17479 (2/2) Protein of unknown function (DUF3048) C-terminal domain
PF13411 (2/2) MerR HTH family regulatory protein
PF11258 (2/2) Protein of unknown function (DUF3048) N-terminal domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_30880 580.50 +- 193.50 2 0 2 0 0.01 +- 0.00 2 6

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
precursor_jaccard_groups_38465 2222.59 +- 873.41 2 0 0 2 0.01 +- 0.02 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03473 (2/2) MOSC domain
PF01523 (2/2) Putative modulator of DNA gyrase
PF01061 (2/2) ABC-2 type transporter
PF00334 (2/2) Nucleoside diphosphate kinase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_545 11.75 +- 4.16 29 0 1 29 0.21 +- 0.12 29 3

PF13360 (29/29) PQQ-like domain
PF11575 (29/29) FhuF 2Fe-2S C-terminal domain
PF00069 (29/29) Protein kinase domain
precursor_jaccard_groups_30397 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01120 (2/2) Alpha-L-fucosidase
precursor_jaccard_groups_29797 406.57 +- 109.43 2 0 2 0 0.01 +- 0.00 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_36624 113.94 +- 23.94 2 0 0 0 0.04 +- 0.02 2 7

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF00698 (1/2) Acyl transferase domain
precursor_jaccard_groups_26774 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 10

TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13238 (2/2) AAA domain
PF04055 (2/2) Radical SAM superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_21277 47.85 +- 3.82 3 0 0 0 0.18 +- 0.28 3 10

TIGR03328 (3/3) methylthioribulose-1-phosphate dehydratase
TIGR01691 (3/3) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF09754 (3/3) PAC2 family
PF03079 (3/3) ARD/ARD' family
PF01979 (3/3) Amidohydrolase family
PF01048 (3/3) Phosphorylase superfamily
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_549 190.62 +- 171.57 7 0 0 0 0.06 +- 0.14 7 2

PF00248 (7/7) Aldo/keto reductase family
PF08007 (6/7) Cupin superfamily protein
precursor_jaccard_groups_23274 63.82 +- 5.91 2 0 0 0 0.18 +- 0.21 2 12

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF12172 (1/2) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF01204 (1/2) Trehalase
PF01012 (1/2) Electron transfer flavoprotein domain
PF00766 (1/2) Electron transfer flavoprotein FAD-binding domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_13862 709.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 8

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF17132 (2/2) alpha-L-rhamnosidase
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02057 (2/2) Glycosyl hydrolase family 59
precursor_jaccard_groups_16817 605.13 +- 492.43 3 0 0 0 0.03 +- 0.05 3 10

PF14310 (3/3) Fibronectin type III-like domain
PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF03636 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (3/3) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (3/3) Glycosyl hydrolase family 65 central catalytic domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_29669 1032.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF08666 (1/2) SAF domain
PF01478 (1/2) Type IV leader peptidase family
PF00437 (1/2) Type II/IV secretion system protein
precursor_jaccard_groups_43860 227.50 +- 32.50 2 0 2 0 0.01 +- 0.00 2 2

PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
precursor_jaccard_groups_8767 519.03 +- 169.70 5 0 5 0 0.02 +- 0.02 5 16

TIGR02151 (5/5) isopentenyl-diphosphate delta-isomerase, type 2
TIGR01835 (5/5) hydroxymethylglutaryl-CoA synthase
TIGR01240 (5/5) diphosphomevalonate decarboxylase
TIGR01220 (5/5) phosphomevalonate kinase
TIGR00549 (5/5) mevalonate kinase
PF18376 (5/5) Mevalonate 5-diphosphate decarboxylase C-terminal domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08544 (5/5) GHMP kinases C terminal
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08540 (5/5) Hydroxymethylglutaryl-coenzyme A synthase C terminal
PF01593 (5/5) Flavin containing amine oxidoreductase
PF01154 (5/5) Hydroxymethylglutaryl-coenzyme A synthase N terminal
PF01070 (5/5) FMN-dependent dehydrogenase
PF00368 (5/5) Hydroxymethylglutaryl-coenzyme A reductase
PF00348 (5/5) Polyprenyl synthetase
PF00288 (5/5) GHMP kinases N terminal domain
precursor_jaccard_groups_8765 28.90 +- 3.70 3 0 0 0 0.18 +- 0.17 3 1

PF00082 (3/3) Subtilase family
precursor_jaccard_groups_4656 28.39 +- 10.54 7 0 0 0 0.21 +- 0.32 7 7

TIGR01460 (7/7) HAD hydrolase, family IIA
PF13344 (7/7) Haloacid dehalogenase-like hydrolase
PF13242 (7/7) HAD-hyrolase-like
PF04203 (7/7) Sortase domain
PF01663 (4/7) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01341 (4/7) Glycosyl hydrolases family 6
PF01145 (4/7) SPFH domain / Band 7 family
precursor_jaccard_groups_25973 134.22 +- 18.67 2 0 2 0 0.03 +- 0.05 2 4

PF13560 (2/2) Helix-turn-helix domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00756 (2/2) Putative esterase
precursor_jaccard_groups_4652 116.33 +- 15.55 9 0 0 0 0.08 +- 0.19 9 13

PF14117 (9/9) Domain of unknown function (DUF4287)
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF06197 (9/9) Protein of unknown function (DUF998)
PF02771 (9/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF01979 (9/9) Amidohydrolase family
PF01575 (9/9) MaoC like domain
PF00501 (9/9) AMP-binding enzyme
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (9/9) Aminotransferase class I and II
PF00132 (9/9) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_21306 100.33 +- 20.27 3 0 0 0 0.02 +- 0.02 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_20783 182.92 +- 27.92 3 0 3 0 0.17 +- 0.34 3 11

PF13424 (3/3) Tetratricopeptide repeat
PF06259 (3/3) Alpha/beta hydrolase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01757 (3/3) Acyltransferase family
PF01177 (3/3) Asp/Glu/Hydantoin racemase
PF01061 (3/3) ABC-2 type transporter
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_30776 258.43 +- 108.63 2 0 0 0 0.04 +- 0.04 2 7

PF14525 (2/2) AraC-binding-like domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_20789 256.85 +- 68.15 2 0 0 0 0.04 +- 0.05 2 5

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_12189 26.65 +- 9.96 2 0 0 0 0.19 +- 0.35 2 8

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR01550 (2/2) death-on-curing family protein
PF07690 (2/2) Major Facilitator Superfamily
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02661 (2/2) Fic/DOC family
PF00082 (2/2) Subtilase family
PF09339 (1/2) IclR helix-turn-helix domain
PF05362 (1/2) Lon protease (S16) C-terminal proteolytic domain
precursor_jaccard_groups_15938 44.50 +- 4.91 2 0 0 0 0.21 +- 0.19 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF11941 (2/2) Domain of unknown function (DUF3459)
PF01553 (2/2) Acyltransferase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_21656 16.46 +- 2.59 3 0 0 0 0.19 +- 0.11 3 5

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (3/3) BFD-like [2Fe-2S] binding domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_21096 14.16 +- 0.00 3 0 0 0 0.21 +- 0.07 3 5

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF04616 (3/3) Glycosyl hydrolases family 43
PF03664 (3/3) Glycosyl hydrolase family 62
PF01341 (3/3) Glycosyl hydrolases family 6
PF00331 (3/3) Glycosyl hydrolase family 10
precursor_jaccard_groups_20255 10.11 +- 0.29 2 0 0 0 0.20 +- 0.01 2 5

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
precursor_jaccard_groups_25202 165.86 +- 0.00 2 0 2 0 0.02 +- 0.02 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13601 (2/2) Winged helix DNA-binding domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03403 (2/2) Platelet-activating factor acetylhydrolase, isoform II
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_20253 182.55 +- 49.54 3 0 3 0 0.07 +- 0.09 3 10

PF16864 (3/3) Dimerisation domain
PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF04672 (3/3) S-adenosyl methyltransferase
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00891 (3/3) O-methyltransferase domain
PF00664 (3/3) ABC transporter transmembrane region
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_783 131.75 +- 65.81 42 0 29 42 0.05 +- 0.04 42 3

PF13649 (42/42) Methyltransferase domain
PF07690 (42/42) Major Facilitator Superfamily
PF04055 (42/42) Radical SAM superfamily
precursor_jaccard_groups_26178 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_39536 54.61 +- 10.39 2 0 2 0 0.04 +- 0.06 2 10

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF13354 (2/2) Beta-lactamase enzyme family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF03621 (2/2) MbtH-like protein
PF03588 (2/2) Leucyl/phenylalanyl-tRNA protein transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_21784 475.33 +- 60.36 3 0 0 3 0.01 +- 0.00 3 7

TIGR04267 (3/3) HEXXH motif domain
PF07690 (3/3) Major Facilitator Superfamily
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01523 (3/3) Putative modulator of DNA gyrase
PF00899 (3/3) ThiF family
TIGR03891 (2/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/3) Lantibiotic biosynthesis dehydratase C-term
precursor_jaccard_groups_40109 103.66 +- 11.52 2 0 0 0 0.04 +- 0.07 2 10

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF01614 (2/2) Bacterial transcriptional regulator
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00501 (1/2) AMP-binding enzyme
PF00175 (1/2) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_15933 903.00 +- 0.00 3 0 3 0 0.01 +- 0.00 3 9

PF12680 (3/3) SnoaL-like domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF07366 (3/3) SnoaL-like polyketide cyclase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00171 (3/3) Aldehyde dehydrogenase family
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_19927 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_14148 17.86 +- 6.20 4 0 0 0 0.19 +- 0.20 4 4

PF01757 (4/4) Acyltransferase family
PF00571 (4/4) CBS domain
PF03471 (3/4) Transporter associated domain
PF01595 (3/4) Cyclin M transmembrane N-terminal domain
precursor_jaccard_groups_40105 29.66 +- 0.00 2 0 0 0 0.13 +- 0.05 2 5

PF14542 (2/2) GCN5-related N-acetyl-transferase
PF07969 (2/2) Amidohydrolase family
PF07681 (2/2) DoxX
PF06912 (2/2) Protein of unknown function (DUF1275)
PF00857 (2/2) Isochorismatase family
precursor_jaccard_groups_37466 87.43 +- 14.81 2 0 0 0 0.11 +- 0.12 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_3569 13.61 +- 4.20 4 0 4 0 0.19 +- 0.24 4 3

PF13424 (4/4) Tetratricopeptide repeat
PF08241 (4/4) Methyltransferase domain
PF00348 (4/4) Polyprenyl synthetase
precursor_jaccard_groups_38165 68.00 +- 18.00 2 0 0 0 0.06 +- 0.04 2 6

PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01206 (2/2) Sulfurtransferase TusA
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00581 (2/2) Rhodanese-like domain
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_24154 44.01 +- 3.88 2 0 2 0 0.09 +- 0.18 2 4

TIGR00377 (2/2) anti-anti-sigma factor
PF01740 (2/2) STAS domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_769 44.32 +- 14.63 8 0 0 0 0.06 +- 0.05 8 2

PF00724 (8/8) NADH:flavin oxidoreductase / NADH oxidase family
PF00171 (8/8) Aldehyde dehydrogenase family
precursor_jaccard_groups_17560 145.36 +- 40.36 2 0 0 0 0.07 +- 0.10 2 9

PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR00218 (1/2) mannose-6-phosphate isomerase, class I
PF03425 (1/2) Carbohydrate binding domain (family 11)
precursor_jaccard_groups_13045 92.56 +- 69.77 4 0 0 0 0.09 +- 0.09 4 10

TIGR01428 (4/4) haloacid dehalogenase, type II
PF12973 (4/4) ChrR Cupin-like domain
PF01909 (4/4) Nucleotidyltransferase domain
PF00144 (4/4) Beta-lactamase
PF07876 (3/4) Stress responsive A/B Barrel Domain
PF07690 (3/4) Major Facilitator Superfamily
PF13419 (2/4) Haloacid dehalogenase-like hydrolase
PF03466 (2/4) LysR substrate binding domain
PF00702 (2/4) haloacid dehalogenase-like hydrolase
PF00126 (2/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_4242 119.27 +- 80.89 8 0 0 0 0.11 +- 0.13 8 10

TIGR01300 (8/8) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (8/8) Domain of unknown function (DUF4040)
PF07690 (8/8) Major Facilitator Superfamily
PF04066 (8/8) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (8/8) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (8/8) Na+/H+ antiporter subunit
PF01899 (8/8) Na+/H+ ion antiporter subunit
PF00662 (8/8) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00361 (8/8) Proton-conducting membrane transporter
PF00420 (7/8) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
precursor_jaccard_groups_13041 238.16 +- 71.44 2 0 0 0 0.05 +- 0.14 2 22

TIGR03971 (2/2) SDR family mycofactocin-dependent oxidoreductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
PF17939 (1/2) Tetracyclin repressor-like, C-terminal domain
PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF08531 (1/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (1/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_30174 22.92 +- 3.39 2 0 0 0 0.18 +- 0.18 2 10

PF13185 (2/2) GAF domain
PF12728 (2/2) Helix-turn-helix domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF08448 (2/2) PAS fold
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05122 (2/2) Mobile element transfer protein
PF01580 (2/2) FtsK/SpoIIIE family
PF00589 (2/2) Phage integrase family
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_169 93.70 +- 48.31 119 0 0 10 0.17 +- 0.15 119 4

PF07811 (119/119) TadE-like protein
PF00482 (119/119) Type II secretion system (T2SS), protein F
PF00437 (119/119) Type II/IV secretion system protein
PF13400 (118/119) Putative Flp pilus-assembly TadE/G-like
precursor_jaccard_groups_40320 36.20 +- 4.24 2 0 0 0 0.20 +- 0.22 2 8

PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
PF00027 (2/2) Cyclic nucleotide-binding domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
precursor_jaccard_groups_20439 197.39 +- 31.14 3 0 0 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_10886 64.75 +- 9.02 4 0 0 0 0.11 +- 0.06 4 12

TIGR03211 (4/4) catechol 2,3 dioxygenase
PF13520 (4/4) Amino acid permease
PF07729 (4/4) FCD domain
PF07690 (4/4) Major Facilitator Superfamily
PF05199 (4/4) GMC oxidoreductase
PF04303 (4/4) PrpF protein
PF03737 (4/4) Aldolase/RraA
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00732 (4/4) GMC oxidoreductase
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_jaccard_groups_162 28.60 +- 29.19 88 0 8 0 0.18 +- 0.10 88 3

PF00355 (87/88) Rieske [2Fe-2S] domain
PF00111 (87/88) 2Fe-2S iron-sulfur cluster binding domain
PF00175 (83/88) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_165 43.65 +- 14.66 15 0 14 0 0.18 +- 0.31 15 5

PF17964 (15/15) Bacterial Ig domain
PF13499 (15/15) EF-hand domain pair
PF03734 (15/15) L,D-transpeptidase catalytic domain
PF05425 (14/15) Copper resistance protein D
PF01522 (14/15) Polysaccharide deacetylase
precursor_jaccard_groups_32933 19.31 +- 0.66 2 0 0 0 0.16 +- 0.22 2 7

TIGR00765 (2/2) YihY family inner membrane protein
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03631 (2/2) Virulence factor BrkB
PF01613 (2/2) Flavin reductase like domain
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
precursor_jaccard_groups_29243 122.07 +- 0.00 2 0 0 0 0.09 +- 0.07 2 8

PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03537 (2/2) Glycoside-hydrolase family GH114
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_5634 126.36 +- 82.01 6 0 6 0 0.11 +- 0.21 6 8

TIGR01733 (6/6) amino acid adenylation domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF07690 (6/6) Major Facilitator Superfamily
PF03621 (6/6) MbtH-like protein
PF00975 (6/6) Thioesterase domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
precursor_jaccard_groups_29536 85.77 +- 37.61 2 0 0 0 0.12 +- 0.24 2 10

TIGR02815 (2/2) putative sugar isomerase, AgaS family
TIGR02810 (2/2) D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF08013 (2/2) Tagatose 6 phosphate kinase
PF07702 (2/2) UTRA domain
PF01869 (2/2) BadF/BadG/BcrA/BcrD ATPase family
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_17966 94.74 +- 50.75 3 0 0 0 0.05 +- 0.05 3 10

TIGR03668 (3/3) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (3/3) probable F420-dependent oxidoreductase, Rv2161c family
PF13377 (3/3) Periplasmic binding protein-like domain
PF03779 (3/3) SPW repeat
PF03729 (3/3) Short repeat of unknown function (DUF308)
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00296 (3/3) Luciferase-like monooxygenase
PF02322 (2/3) Cytochrome bd terminal oxidase subunit II
PF01654 (2/3) Cytochrome bd terminal oxidase subunit I
precursor_jaccard_groups_17965 535.39 +- 399.35 3 0 3 3 0.03 +- 0.08 3 7

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (3/3) Histidine kinase
PF06722 (3/3) Protein of unknown function (DUF1205)
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_6812 133.87 +- 64.11 5 0 0 0 0.05 +- 0.15 5 3

PF13343 (5/5) Bacterial extracellular solute-binding protein
PF00561 (5/5) alpha/beta hydrolase fold
PF00485 (5/5) Phosphoribulokinase / Uridine kinase family
precursor_jaccard_groups_28096 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_4087 13.41 +- 3.79 2 0 0 0 0.16 +- 0.31 2 3

TIGR01179 (2/2) UDP-glucose 4-epimerase GalE
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_31977 1167.00 +- 393.00 2 0 0 0 0.01 +- 0.00 2 4

PF17964 (2/2) Bacterial Ig domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF13304 (1/2) AAA domain, putative AbiEii toxin, Type IV TA system
precursor_jaccard_groups_4083 14.30 +- 1.07 8 0 3 0 0.21 +- 0.04 8 6

PF13247 (8/8) 4Fe-4S dicluster domain
PF04879 (8/8) Molybdopterin oxidoreductase Fe4S4 domain
PF01568 (8/8) Molydopterin dinucleotide binding domain
PF00384 (8/8) Molybdopterin oxidoreductase
PF00355 (8/8) Rieske [2Fe-2S] domain
PF00037 (8/8) 4Fe-4S binding domain
precursor_jaccard_groups_13300 275.25 +- 71.07 4 0 4 0 0.01 +- 0.00 4 9

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF12680 (4/4) SnoaL-like domain
PF08242 (4/4) Methyltransferase domain
PF07883 (4/4) Cupin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
precursor_jaccard_groups_2765 65.09 +- 47.23 11 0 1 0 0.06 +- 0.13 11 5

PF03965 (11/11) Penicillinase repressor
PF01435 (11/11) Peptidase family M48
PF00403 (11/11) Heavy-metal-associated domain
PF12229 (10/11) Putative peptidoglycan binding domain
PF04294 (10/11) VanW like protein
precursor_jaccard_groups_2761 142.41 +- 72.76 2 0 2 0 0.06 +- 0.04 2 5

PF13833 (2/2) EF-hand domain pair
PF13499 (2/2) EF-hand domain pair
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07969 (2/2) Amidohydrolase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_2763 193.07 +- 124.69 11 0 11 11 0.03 +- 0.10 11 7

TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (11/11) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (11/11) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF02624 (11/11) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (11/11) Nitroreductase family
PF04738 (10/11) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_40258 255.53 +- 31.14 2 0 0 0 0.05 +- 0.11 2 9

PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF08125 (2/2) Mannitol dehydrogenase C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01232 (2/2) Mannitol dehydrogenase Rossmann domain
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_34419 32.11 +- 2.01 2 0 0 0 0.09 +- 0.11 2 4

PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
precursor_jaccard_groups_24844 40.50 +- 1.11 2 0 2 0 0.22 +- 0.35 2 15

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03061 (2/2) Thioesterase superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_3167 54.72 +- 56.67 12 0 0 0 0.10 +- 0.13 12 6

PF13828 (12/12) Domain of unknown function (DUF4190)
PF09995 (12/12) Uncharacterized protein conserved in bacteria (DUF2236)
PF01738 (12/12) Dienelactone hydrolase family
TIGR00879 (11/12) MFS transporter, sugar porter (SP) family
PF05721 (11/12) Phytanoyl-CoA dioxygenase (PhyH)
PF00083 (11/12) Sugar (and other) transporter
precursor_jaccard_groups_4398 144.48 +- 52.90 5 0 0 0 0.03 +- 0.02 5 9

TIGR00557 (5/5) 4-hydroxythreonine-4-phosphate dehydrogenase PdxA
PF17042 (5/5) Nucleotide-binding C-terminal domain
PF13396 (5/5) Phospholipase_D-nuclease N-terminal
PF09851 (5/5) Short C-terminal domain
PF08220 (5/5) DeoR-like helix-turn-helix domain
PF07690 (5/5) Major Facilitator Superfamily
PF07005 (5/5) Sugar-binding N-terminal domain
PF04166 (5/5) Pyridoxal phosphate biosynthetic protein PdxA
PF00455 (5/5) DeoR C terminal sensor domain
precursor_jaccard_groups_43101 174.75 +- 18.75 2 0 0 0 0.01 +- 0.01 2 2

PF09335 (2/2) SNARE associated Golgi protein
PF08241 (2/2) Methyltransferase domain
precursor_jaccard_groups_28756 157.48 +- 95.83 2 0 0 0 0.11 +- 0.16 2 9

TIGR03707 (2/2) polyphosphate kinase 2
TIGR02315 (2/2) phosphonate ABC transporter, ATP-binding protein
TIGR01098 (2/2) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (2/2) phosphonate ABC transporter, permease protein PhnE
PF12974 (2/2) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF01384 (2/2) Phosphate transporter family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28757 117.28 +- 1.18 2 0 0 0 0.08 +- 0.03 2 5

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_36015 473.57 +- 83.57 2 0 0 0 0.02 +- 0.01 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_4394 569.88 +- 178.51 3 0 3 3 0.01 +- 0.00 3 4

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (3/3) Radical SAM superfamily
PF00248 (3/3) Aldo/keto reductase family
PF12746 (2/3) GNAT acetyltransferase
precursor_jaccard_groups_33996 33.33 +- 1.07 2 0 0 0 0.06 +- 0.01 2 1

PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_3360 170.04 +- 70.06 10 0 0 0 0.07 +- 0.04 10 8

PF10633 (10/10) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (10/10) Alpha mannosidase middle domain
PF01418 (10/10) Helix-turn-helix domain, rpiR family
PF01380 (10/10) SIS domain
PF01074 (10/10) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF13416 (5/10) Bacterial extracellular solute-binding protein
PF01547 (5/10) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_4889 16.59 +- 1.41 3 0 0 0 0.18 +- 0.22 3 10

TIGR00630 (3/3) excinuclease ABC subunit A
PF17755 (3/3) UvrA DNA-binding domain
PF14759 (3/3) Reductase C-terminal
PF13499 (3/3) EF-hand domain pair
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07045 (3/3) Domain of unknown function (DUF1330)
PF04471 (3/3) Restriction endonuclease
PF02342 (3/3) TerD domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_3368 275.86 +- 179.70 11 0 11 11 0.06 +- 0.14 11 9

TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
PF00296 (11/11) Luciferase-like monooxygenase
PF00196 (11/11) Bacterial regulatory proteins, luxR family
PF00072 (11/11) Response regulator receiver domain
PF00005 (11/11) ABC transporter
PF13649 (9/11) Methyltransferase domain
precursor_jaccard_groups_11680 76.59 +- 51.74 3 0 0 0 0.07 +- 0.06 3 3

PF13460 (3/3) NAD(P)H-binding
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_40812 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_13278 72.45 +- 38.08 3 0 0 0 0.04 +- 0.05 3 3

PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
precursor_jaccard_groups_2493 55.12 +- 11.41 14 0 0 0 0.19 +- 0.15 14 6

PF02838 (14/14) Glycosyl hydrolase family 20, domain 2
PF01547 (14/14) Bacterial extracellular solute-binding protein
PF00942 (14/14) Cellulose binding domain
PF00728 (14/14) Glycosyl hydrolase family 20, catalytic domain
PF00722 (14/14) Glycosyl hydrolases family 16
PF00528 (14/14) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_43676 55.71 +- 0.00 2 0 0 0 0.05 +- 0.06 2 4

TIGR01950 (2/2) redox-sensitive transcriptional activator SoxR
PF13411 (2/2) MerR HTH family regulatory protein
PF00877 (2/2) NlpC/P60 family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_34077 462.24 +- 317.76 2 0 1 0 0.05 +- 0.20 2 14

TIGR03889 (2/2) nitrile hydratase accessory protein
TIGR03888 (2/2) nitrile hydratase, beta subunit
TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF13816 (2/2) Haem-containing dehydratase
PF09490 (2/2) Probable cobalt transporter subunit (CbtA)
PF09489 (2/2) Probable cobalt transporter subunit (CbtB)
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
PF01425 (2/2) Amidase
PF00501 (2/2) AMP-binding enzyme
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_42279 1148.36 +- 915.64 2 0 2 0 0.04 +- 0.17 2 21

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00128 (2/2) malonyl CoA-acyl carrier protein transacylase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_2230 53.12 +- 37.89 12 0 1 0 0.10 +- 0.15 12 3

PF01292 (12/12) Prokaryotic cytochrome b561
PF00174 (12/12) Oxidoreductase molybdopterin binding domain
PF07519 (11/12) Tannase and feruloyl esterase
precursor_jaccard_groups_3701 220.84 +- 153.01 10 0 10 0 0.12 +- 0.24 10 19

PF03621 (10/10) MbtH-like protein
PF02797 (10/10) Chalcone and stilbene synthases, C-terminal domain
PF02518 (10/10) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02153 (10/10) Prephenate dehydrogenase
PF01070 (10/10) FMN-dependent dehydrogenase
PF00672 (10/10) HAMP domain
PF00664 (10/10) ABC transporter transmembrane region
PF00512 (10/10) His Kinase A (phospho-acceptor) domain
PF00378 (10/10) Enoyl-CoA hydratase/isomerase
PF00195 (10/10) Chalcone and stilbene synthases, N-terminal domain
PF00155 (10/10) Aminotransferase class I and II
PF00005 (10/10) ABC transporter
TIGR01733 (9/10) amino acid adenylation domain
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF00668 (9/10) Condensation domain
PF00501 (9/10) AMP-binding enzyme
PF12697 (8/10) Alpha/beta hydrolase family
PF00550 (8/10) Phosphopantetheine attachment site
TIGR01720 (5/10) non-ribosomal peptide synthase domain TIGR01720
precursor_jaccard_groups_3703 92.80 +- 28.43 4 0 0 0 0.19 +- 0.30 4 11

PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
TIGR03177 (3/4) Flp pilus assembly protein CpaB
PF16976 (3/4) Flp pilus assembly protein RcpC/CpaB
PF13614 (3/4) AAA domain
PF07811 (3/4) TadE-like protein
PF07730 (3/4) Histidine kinase
PF00691 (3/4) OmpA family
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
PF08666 (2/4) SAF domain
precursor_jaccard_groups_3707 391.64 +- 418.40 6 0 6 0 0.10 +- 0.26 6 16

TIGR01733 (6/6) amino acid adenylation domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF16197 (5/6) Ketoacyl-synthetase C-terminal extension
PF05995 (5/6) Cysteine dioxygenase type I
PF03621 (5/6) MbtH-like protein
PF02801 (5/6) Beta-ketoacyl synthase, C-terminal domain
PF02668 (5/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (5/6) Thioesterase domain
PF00698 (5/6) Acyl transferase domain
PF00109 (5/6) Beta-ketoacyl synthase, N-terminal domain
PF13302 (3/6) Acetyltransferase (GNAT) domain
PF00664 (3/6) ABC transporter transmembrane region
PF00005 (3/6) ABC transporter
precursor_jaccard_groups_44133 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_7287 198.25 +- 41.47 6 0 0 6 0.03 +- 0.01 6 5

PF13480 (6/6) Acetyltransferase (GNAT) domain
PF08282 (6/6) haloacid dehalogenase-like hydrolase
PF04339 (6/6) Peptidogalycan biosysnthesis/recognition
PF04055 (6/6) Radical SAM superfamily
PF00303 (6/6) Thymidylate synthase
precursor_jaccard_groups_19016 178.81 +- 113.41 3 0 0 0 0.04 +- 0.05 3 2

PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_39565 88.24 +- 7.83 2 0 2 0 0.11 +- 0.16 2 17

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17829 (2/2) Gylcosyl hydrolase family 115 C-terminal domain
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF15979 (2/2) Glycosyl hydrolase family 115
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08962 (2/2) Domain of unknown function (DUF1876)
PF07971 (2/2) Glycosyl hydrolase family 92
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00583 (2/2) Acetyltransferase (GNAT) family
PF14310 (1/2) Fibronectin type III-like domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_7443 647.50 +- 2.50 6 0 6 0 0.01 +- 0.00 6 11

PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02812 (6/6) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00856 (6/6) SET domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00208 (6/6) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_2166 105.84 +- 61.51 12 0 0 0 0.16 +- 0.28 12 10

TIGR03177 (12/12) Flp pilus assembly protein CpaB
PF16976 (12/12) Flp pilus assembly protein RcpC/CpaB
PF13614 (12/12) AAA domain
PF07811 (12/12) TadE-like protein
PF00482 (12/12) Type II secretion system (T2SS), protein F
PF00437 (12/12) Type II/IV secretion system protein
PF07730 (11/12) Histidine kinase
PF00691 (11/12) OmpA family
PF00196 (11/12) Bacterial regulatory proteins, luxR family
PF00072 (11/12) Response regulator receiver domain
precursor_jaccard_groups_10532 14.20 +- 0.52 2 0 0 2 0.21 +- 0.29 2 4

PF13360 (2/2) PQQ-like domain
PF06906 (2/2) Protein of unknown function (DUF1272)
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01329 (2/2) Pterin 4 alpha carbinolamine dehydratase
precursor_jaccard_groups_6398 127.88 +- 75.05 7 0 7 7 0.06 +- 0.05 7 6

PF13471 (7/7) Transglutaminase-like superfamily
PF05402 (7/7) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (7/7) Asparagine synthase
PF00664 (7/7) ABC transporter transmembrane region
PF00005 (7/7) ABC transporter
PF00196 (6/7) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_972 86.29 +- 109.83 10 0 0 0 0.10 +- 0.20 10 4

TIGR04267 (10/10) HEXXH motif domain
PF14016 (10/10) Protein of unknown function (DUF4232)
PF08962 (10/10) Domain of unknown function (DUF1876)
PF00156 (10/10) Phosphoribosyl transferase domain
precursor_jaccard_groups_1847 440.56 +- 238.32 20 0 0 20 0.03 +- 0.05 20 10

PF14833 (20/20) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (20/20) Glutamine amidotransferase domain
PF13480 (20/20) Acetyltransferase (GNAT) domain
PF07690 (20/20) Major Facilitator Superfamily
PF03641 (20/20) Possible lysine decarboxylase
PF03446 (20/20) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (20/20) N-terminal domain of galactosyltransferase
PF01041 (20/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (20/20) Asparagine synthase
PF00300 (20/20) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_8605 25.67 +- 0.72 3 0 0 0 0.12 +- 0.11 3 5

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07702 (3/3) UTRA domain
PF01872 (3/3) RibD C-terminal domain
PF00535 (3/3) Glycosyl transferase family 2
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_3940 64.82 +- 27.28 3 0 0 0 0.16 +- 0.05 3 18

TIGR01374 (3/3) sarcosine oxidase, delta subunit family
TIGR01373 (3/3) sarcosine oxidase, beta subunit family
PF16350 (3/3) FAD dependent oxidoreductase central domain
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (3/3) Glycine cleavage T-protein C-terminal barrel domain
PF04267 (3/3) Sarcosine oxidase, delta subunit family
PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF02882 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (3/3) Aminomethyltransferase folate-binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00763 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
TIGR01186 (2/3) glycine betaine/L-proline transport ATP binding subunit
PF17806 (2/3) Sarcosine oxidase A3 domain
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/3) Sarcosine oxidase, gamma subunit family
PF00171 (2/3) Aldehyde dehydrogenase family
PF00005 (2/3) ABC transporter
precursor_jaccard_groups_23314 24.12 +- 8.30 3 0 0 0 0.18 +- 0.32 3 12

TIGR00765 (3/3) YihY family inner membrane protein
TIGR00105 (3/3) ribosomal protein bL31
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF05922 (3/3) Peptidase inhibitor I9
PF03631 (3/3) Virulence factor BrkB
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF01756 (3/3) Acyl-CoA oxidase
PF01197 (3/3) Ribosomal protein L31
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00082 (3/3) Subtilase family
PF11941 (2/3) Domain of unknown function (DUF3459)
PF00128 (2/3) Alpha amylase, catalytic domain
precursor_jaccard_groups_9398 166.53 +- 82.45 5 0 0 0 0.02 +- 0.03 5 3

PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00877 (5/5) NlpC/P60 family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_7666 18.88 +- 3.69 5 0 0 0 0.22 +- 0.20 5 19

TIGR03346 (5/5) ATP-dependent chaperone protein ClpB
TIGR02350 (5/5) chaperone protein DnaK
TIGR01068 (5/5) thioredoxin
PF17871 (5/5) AAA lid domain
PF13591 (5/5) MerR HTH family regulatory protein
PF13515 (5/5) Fusaric acid resistance protein-like
PF12805 (5/5) FUSC-like inner membrane protein yccS
PF10431 (5/5) C-terminal, D2-small domain, of ClpB protein
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (5/5) AAA domain (Cdc48 subfamily)
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF02148 (5/5) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (5/5) DnaJ C terminal domain
PF01025 (5/5) GrpE
PF00226 (5/5) DnaJ domain
PF00085 (5/5) Thioredoxin
PF00027 (5/5) Cyclic nucleotide-binding domain
PF00012 (5/5) Hsp70 protein
PF00004 (5/5) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_7664 276.38 +- 115.50 6 0 6 0 0.03 +- 0.13 6 9

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00891 (6/6) O-methyltransferase domain
precursor_jaccard_groups_8499 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_jaccard_groups_9395 148.56 +- 106.11 5 0 0 5 0.10 +- 0.14 5 16

TIGR04283 (5/5) transferase 2, rSAM/selenodomain-associated
TIGR04282 (5/5) transferase 1, rSAM/selenodomain-associated
PF12850 (5/5) Calcineurin-like phosphoesterase superfamily domain
PF09837 (5/5) Uncharacterized protein conserved in bacteria (DUF2064)
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04055 (5/5) Radical SAM superfamily
PF02852 (5/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF02687 (5/5) FtsX-like permease family
PF01048 (5/5) Phosphorylase superfamily
PF00535 (5/5) Glycosyl transferase family 2
PF00005 (5/5) ABC transporter
PF00672 (4/5) HAMP domain
PF00512 (4/5) His Kinase A (phospho-acceptor) domain
PF00486 (4/5) Transcriptional regulatory protein, C terminal
PF00072 (4/5) Response regulator receiver domain
PF07291 (3/5) Methylamine utilisation protein MauE
precursor_jaccard_groups_32150 16.01 +- 2.56 2 0 0 0 0.19 +- 0.29 2 7

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF13560 (2/2) Helix-turn-helix domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF04149 (2/2) Domain of unknown function (DUF397)
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00754 (2/2) F5/8 type C domain
precursor_jaccard_groups_21 44.23 +- 57.64 17 0 2 0 0.13 +- 0.26 17 3

PF03777 (17/17) ChpA-C
TIGR03296 (9/17) M6 family metalloprotease domain
PF09339 (9/17) IclR helix-turn-helix domain
precursor_jaccard_groups_15027 29.99 +- 4.41 4 0 0 0 0.16 +- 0.32 4 10

PF17042 (4/4) Nucleotide-binding C-terminal domain
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
TIGR01935 (3/4) RraA family
PF04332 (3/4) Protein of unknown function (DUF475)
PF03737 (3/4) Aldolase/RraA
precursor_jaccard_groups_7060 12.72 +- 0.45 3 0 0 0 0.24 +- 0.38 3 7

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13560 (3/3) Helix-turn-helix domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08031 (3/3) Berberine and berberine like
PF04149 (3/3) Domain of unknown function (DUF397)
PF01565 (3/3) FAD binding domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_39104 45.52 +- 7.25 2 0 0 0 0.07 +- 0.09 2 8

PF14759 (2/2) Reductase C-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08022 (2/2) FAD-binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04205 (2/2) FMN-binding domain
PF02424 (2/2) ApbE family
PF00083 (2/2) Sugar (and other) transporter
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_32554 46.64 +- 4.19 2 0 0 0 0.22 +- 0.34 2 5

PF05995 (2/2) Cysteine dioxygenase type I
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_43075 580.50 +- 0.00 2 0 0 0 0.02 +- 0.00 2 7

TIGR01767 (2/2) S-methyl-5-thioribose kinase
TIGR00512 (2/2) S-methyl-5-thioribose-1-phosphate isomerase
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01008 (2/2) Initiation factor 2 subunit family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7068 800.06 +- 256.65 6 0 5 0 0.01 +- 0.01 6 11

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_jaccard_groups_10657 18.77 +- 0.34 4 0 0 0 0.21 +- 0.39 4 12

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
TIGR00209 (4/4) galactose-1-phosphate uridylyltransferase
TIGR00131 (4/4) galactokinase
PF14099 (4/4) Polysaccharide lyase
PF10509 (4/4) Galactokinase galactose-binding signature
PF08544 (4/4) GHMP kinases C terminal
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF02744 (4/4) Galactose-1-phosphate uridyl transferase, C-terminal domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF01087 (4/4) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF00455 (4/4) DeoR C terminal sensor domain
PF00288 (4/4) GHMP kinases N terminal domain
precursor_jaccard_groups_36812 2404.29 +- 175.71 2 0 2 0 0.01 +- 0.00 2 5

PF13463 (2/2) Winged helix DNA-binding domain
PF09084 (2/2) NMT1/THI5 like
PF04909 (2/2) Amidohydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9715 148.40 +- 67.91 5 0 0 0 0.02 +- 0.02 5 3

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_15023 202.96 +- 221.81 3 0 0 0 0.11 +- 0.24 3 5

PF04961 (3/3) Formiminotransferase-cyclodeaminase
PF02882 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01885 (3/3) RNA 2'-phosphotransferase, Tpt1 / KptA family
PF00763 (3/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00561 (2/3) alpha/beta hydrolase fold
precursor_jaccard_groups_18463 645.00 +- 0.00 3 0 3 0 0.01 +- 0.00 3 10

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF04101 (3/3) Glycosyltransferase family 28 C-terminal domain
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03023 (3/3) Lipid II flippase MurJ
PF02397 (3/3) Bacterial sugar transferase
PF01522 (3/3) Polysaccharide deacetylase
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_6006 152.88 +- 42.13 6 0 4 0 0.02 +- 0.01 6 4

PF14759 (6/6) Reductase C-terminal
PF14518 (6/6) Iron-containing redox enzyme
PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (6/6) Rieske [2Fe-2S] domain
precursor_jaccard_groups_29887 81.42 +- 18.09 2 0 2 0 0.12 +- 0.06 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13377 (2/2) Periplasmic binding protein-like domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_39093 2387.67 +- 710.67 2 0 0 0 0.01 +- 0.00 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00673 (2/2) cyanase
PF13379 (2/2) NMT1-like family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02566 (2/2) OsmC-like protein
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01925 (2/2) Sulfite exporter TauE/SafE
PF01613 (2/2) Flavin reductase like domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1930 30.61 +- 17.80 10 0 0 0 0.15 +- 0.22 10 5

PF14016 (10/10) Protein of unknown function (DUF4232)
PF03473 (10/10) MOSC domain
PF01636 (10/10) Phosphotransferase enzyme family
PF13560 (9/10) Helix-turn-helix domain
PF04149 (7/10) Domain of unknown function (DUF397)
precursor_jaccard_groups_18647 451.12 +- 125.20 3 0 2 0 0.03 +- 0.03 3 10

PF14742 (3/3) N-terminal domain of (some) glycogen debranching enzymes
PF10282 (3/3) Lactonase, 7-bladed beta-propeller
PF07883 (3/3) Cupin domain
PF07729 (3/3) FCD domain
PF06202 (3/3) Amylo-alpha-1,6-glucosidase
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF03600 (3/3) Citrate transporter
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_15542 165.73 +- 61.23 3 0 3 0 0.11 +- 0.15 3 17

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
TIGR01746 (2/3) thioester reductase domain
TIGR01733 (2/3) amino acid adenylation domain
PF07993 (2/3) Male sterility protein
PF05118 (2/3) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (2/3) Condensation domain
precursor_jaccard_groups_18317 31.25 +- 2.89 3 0 0 0 0.10 +- 0.06 3 7

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03920 (3/3) type VII secretion integral membrane protein EccD
TIGR03919 (3/3) type VII secretion protein EccB
PF08817 (3/3) WXG100 protein secretion system (Wss), protein YukD
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/3) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_15236 57.75 +- 16.78 3 0 0 0 0.04 +- 0.03 3 3

TIGR03561 (3/3) peroxiredoxin, Ohr subfamily
PF02566 (3/3) OsmC-like protein
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_18867 816.86 +- 486.69 3 0 0 0 0.03 +- 0.06 3 9

TIGR03168 (3/3) hexose kinase, 1-phosphofructokinase family
TIGR00167 (3/3) ketose-bisphosphate aldolase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01301 (3/3) Glycosyl hydrolases family 35
PF01116 (3/3) Fructose-bisphosphate aldolase class-II
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00480 (3/3) ROK family
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_jaccard_groups_18640 347.40 +- 221.09 3 0 0 0 0.05 +- 0.18 3 9

TIGR02170 (3/3) thymidylate synthase, flavin-dependent
TIGR00730 (3/3) TIGR00730 family protein
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (3/3) ATP-grasp domain
PF03641 (3/3) Possible lysine decarboxylase
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02511 (3/3) Thymidylate synthase complementing protein
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_6628 604.00 +- 244.67 3 0 0 0 0.01 +- 0.00 3 4

PF14478 (3/3) Domain of unknown function (DUF4430)
PF13377 (3/3) Periplasmic binding protein-like domain
PF01301 (3/3) Glycosyl hydrolases family 35
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_2942 146.09 +- 103.87 8 0 8 0 0.18 +- 0.23 8 14

TIGR01733 (8/8) amino acid adenylation domain
TIGR01720 (8/8) non-ribosomal peptide synthase domain TIGR01720
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF01382 (8/8) Avidin family
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00106 (8/8) short chain dehydrogenase
TIGR01727 (5/8) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (5/8) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (5/8) Binding-protein-dependent transport system inner membrane component
PF00496 (5/8) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (5/8) ABC transporter
precursor_jaccard_groups_32730 22.42 +- 9.83 2 0 0 0 0.11 +- 0.09 2 3

PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01323 (2/2) DSBA-like thioredoxin domain
precursor_jaccard_groups_35101 280.92 +- 239.08 2 0 2 0 0.05 +- 0.14 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13649 (2/2) Methyltransferase domain
PF13621 (2/2) Cupin-like domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_7713 39.16 +- 3.29 2 0 0 0 0.10 +- 0.07 2 5

TIGR01382 (2/2) intracellular protease, PfpI family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF03928 (2/2) Haem-degrading
PF01965 (2/2) DJ-1/PfpI family
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_8972 655.79 +- 464.04 5 0 5 5 0.04 +- 0.14 5 14

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00630 (5/5) excinuclease ABC subunit A
PF17755 (5/5) UvrA DNA-binding domain
PF07730 (5/5) Histidine kinase
PF07690 (5/5) Major Facilitator Superfamily
PF06722 (5/5) Protein of unknown function (DUF1205)
PF04101 (5/5) Glycosyltransferase family 28 C-terminal domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00881 (5/5) Nitroreductase family
PF00190 (5/5) Cupin
precursor_jaccard_groups_36924 204.23 +- 0.06 2 0 0 2 0.10 +- 0.29 2 11

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR01343 (2/2) homoaconitate hydratase family protein
TIGR00049 (2/2) iron-sulfur cluster assembly accessory protein
PF08241 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF01521 (2/2) Iron-sulphur cluster biosynthesis
PF01106 (2/2) NifU-like domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_22685 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
precursor_jaccard_groups_39039 99.95 +- 29.05 2 0 0 0 0.02 +- 0.02 2 5

PF17866 (2/2) AAA lid domain
PF13229 (2/2) Right handed beta helix region
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00082 (2/2) Subtilase family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_8976 126.26 +- 39.60 2 0 0 0 0.02 +- 0.01 2 3

PF05995 (2/2) Cysteine dioxygenase type I
PF00581 (2/2) Rhodanese-like domain
PF06094 (1/2) Gamma-glutamyl cyclotransferase, AIG2-like
precursor_jaccard_groups_6713 54.13 +- 9.39 6 0 0 6 0.18 +- 0.34 6 12

TIGR04276 (6/6) FxsC C-terminal domain
TIGR04269 (6/6) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (6/6) HEXXH motif domain
PF13676 (6/6) TIR domain
PF13424 (6/6) Tetratricopeptide repeat
PF13407 (6/6) Periplasmic binding protein domain
PF13374 (6/6) Tetratricopeptide repeat
PF04055 (6/6) Radical SAM superfamily
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF02522 (6/6) Aminoglycoside 3-N-acetyltransferase
PF00931 (6/6) NB-ARC domain
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_33733 25.84 +- 12.40 2 0 0 0 0.15 +- 0.29 2 6

TIGR00649 (2/2) beta-CASP ribonuclease, RNase J family
PF17770 (2/2) Ribonuclease J C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07521 (2/2) Zn-dependent metallo-hydrolase RNA specificity domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_15301 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_39037 76.68 +- 37.98 2 0 0 0 0.05 +- 0.06 2 5

PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07690 (2/2) Major Facilitator Superfamily
PF00534 (2/2) Glycosyl transferases group 1
PF13649 (1/2) Methyltransferase domain
precursor_jaccard_groups_9155 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_41971 390.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_13696 375.81 +- 126.83 4 0 3 0 0.03 +- 0.04 4 14

TIGR03619 (4/4) probable F420-dependent oxidoreductase, Rv2161c family
PF14864 (4/4) Alkyl sulfatase C-terminal
PF13847 (4/4) Methyltransferase domain
PF07977 (4/4) FabA-like domain
PF03061 (4/4) Thioesterase superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF14863 (3/4) Alkyl sulfatase dimerisation
PF09076 (3/4) Beta/Gamma crystallin
PF00753 (3/4) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_31916 174.34 +- 16.77 2 0 0 0 0.05 +- 0.03 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
precursor_jaccard_groups_27231 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_37661 133.61 +- 63.96 2 0 2 0 0.09 +- 0.20 2 22

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16864 (2/2) Dimerisation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF04389 (2/2) Peptidase family M28
PF03621 (2/2) MbtH-like protein
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13847 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_1442 327.07 +- 116.49 3 0 1 3 0.02 +- 0.02 3 12

TIGR03969 (3/3) mycofactocin precursor
TIGR03967 (3/3) putative mycofactocin binding protein MftB
TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (3/3) mycofactocin system glycosyltransferase
TIGR03964 (3/3) mycofactocin system creatininase family protein
TIGR03962 (3/3) mycofactocin radical SAM maturase
PF13632 (3/3) Glycosyl transferase family group 2
PF04055 (3/3) Radical SAM superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01070 (3/3) FMN-dependent dehydrogenase
PF13186 (2/3) Iron-sulfur cluster-binding domain
PF00535 (2/3) Glycosyl transferase family 2
precursor_jaccard_groups_8375 42.25 +- 29.71 3 0 1 0 0.10 +- 0.14 3 4

PF00480 (3/3) ROK family
PF00027 (3/3) Cyclic nucleotide-binding domain
PF09992 (2/3) Phosphodiester glycosidase
PF01510 (2/3) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_5139 957.03 +- 990.22 5 0 0 0 0.05 +- 0.18 5 7

PF05331 (5/5) Protein of unknown function (DUF742)
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF01636 (5/5) Phosphotransferase enzyme family
PF00067 (5/5) Cytochrome P450
PF00005 (5/5) ABC transporter
PF13489 (3/5) Methyltransferase domain
precursor_jaccard_groups_1609 46.64 +- 3.06 3 0 0 0 0.06 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain
precursor_jaccard_groups_15125 44.20 +- 14.04 3 0 1 0 0.20 +- 0.32 3 8

PF13560 (3/3) Helix-turn-helix domain
PF12833 (3/3) Helix-turn-helix domain
PF04672 (3/3) S-adenosyl methyltransferase
PF04149 (3/3) Domain of unknown function (DUF397)
PF00005 (3/3) ABC transporter
PF13377 (2/3) Periplasmic binding protein-like domain
PF09844 (2/3) Uncharacterized conserved protein (COG2071)
PF07690 (2/3) Major Facilitator Superfamily
precursor_jaccard_groups_33289 28.73 +- 9.97 2 0 0 0 0.07 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00455 (2/2) DeoR C terminal sensor domain
precursor_jaccard_groups_11329 49.23 +- 20.12 3 0 0 0 0.11 +- 0.09 3 5

PF08220 (3/3) DeoR-like helix-turn-helix domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (3/3) DeoR C terminal sensor domain
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_15126 65.43 +- 21.35 3 0 0 0 0.05 +- 0.07 3 5

PF10633 (3/3) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF07729 (3/3) FCD domain
PF05448 (3/3) Acetyl xylan esterase (AXE1)
PF01494 (3/3) FAD binding domain
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_4409 79.19 +- 52.54 9 0 0 0 0.17 +- 0.32 9 18

PF17863 (9/9) AAA lid domain
PF13519 (9/9) von Willebrand factor type A domain
PF13365 (9/9) Trypsin-like peptidase domain
PF07726 (9/9) ATPase family associated with various cellular activities (AAA)
PF07584 (9/9) Aerotolerance regulator N-terminal
PF02518 (9/9) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01882 (9/9) Protein of unknown function DUF58
PF00672 (9/9) HAMP domain
PF00512 (9/9) His Kinase A (phospho-acceptor) domain
PF00486 (9/9) Transcriptional regulatory protein, C terminal
PF00072 (9/9) Response regulator receiver domain
TIGR00838 (8/9) argininosuccinate lyase
TIGR00785 (8/9) transporter, divalent anion:Na+ symporter (DASS) family
TIGR00032 (8/9) argininosuccinate synthase
PF14698 (8/9) Argininosuccinate lyase C-terminal
PF00939 (8/9) Sodium:sulfate symporter transmembrane region
PF00764 (8/9) Arginosuccinate synthase
PF00206 (8/9) Lyase
precursor_jaccard_groups_14437 104.39 +- 13.39 2 0 0 0 0.03 +- 0.02 2 7

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_12305 2666.00 +- 121.62 3 0 3 3 0.01 +- 0.00 3 5

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_37035 432.73 +- 22.27 2 0 0 2 0.03 +- 0.04 2 12

PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (2/2) Glutamine amidotransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00962 (2/2) Adenosine/AMP deaminase
PF00733 (2/2) Asparagine synthase
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00535 (1/2) Glycosyl transferase family 2
precursor_jaccard_groups_36034 117.56 +- 27.56 2 0 1 0 0.03 +- 0.03 2 5

PF08124 (2/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07690 (2/2) Major Facilitator Superfamily
PF02884 (2/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (2/2) Polysaccharide lyase family 8, super-sandwich domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_33041 86.61 +- 19.01 2 0 2 0 0.17 +- 0.27 2 22

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02222 (2/2) ATP-grasp domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_36032 29.50 +- 0.00 2 0 1 0 0.10 +- 0.05 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_18086 1034.67 +- 3.77 3 0 0 0 0.01 +- 0.00 3 5

PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07690 (3/3) Major Facilitator Superfamily
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_27305 182.66 +- 123.23 2 0 2 0 0.10 +- 0.23 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_994 30.36 +- 4.04 2 0 1 2 0.07 +- 0.08 2 4

PF12833 (2/2) Helix-turn-helix domain
PF08922 (2/2) Domain of unknown function (DUF1905)
PF06445 (2/2) GyrI-like small molecule binding domain
PF05147 (2/2) Lanthionine synthetase C-like protein
precursor_jaccard_groups_41576 159.00 +- 17.98 2 0 0 0 0.11 +- 0.16 2 21

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13380 (2/2) CoA binding domain
PF09084 (2/2) NMT1/THI5 like
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04016 (2/2) Putative heavy-metal chelation
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13549 (1/2) ATP-grasp domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00285 (1/2) Citrate synthase, C-terminal domain
precursor_jaccard_groups_19220 401.61 +- 29.35 3 0 3 0 0.02 +- 0.01 3 11

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF03795 (3/3) YCII-related domain
PF02310 (3/3) B12 binding domain
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_42685 22.45 +- 0.32 2 0 0 0 0.18 +- 0.10 2 8

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04909 (2/2) Amidohydrolase
PF01575 (2/2) MaoC like domain
PF00501 (2/2) AMP-binding enzyme
PF00083 (2/2) Sugar (and other) transporter
TIGR01923 (1/2) O-succinylbenzoate-CoA ligase
precursor_jaccard_groups_35854 160.86 +- 68.07 2 0 2 0 0.11 +- 0.28 2 18

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16911 (2/2) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF09339 (2/2) IclR helix-turn-helix domain
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/2) CoA-transferase family III
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (2/2) Bacterial transcriptional regulator
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_36387 464.19 +- 100.19 2 0 0 0 0.02 +- 0.02 2 10

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08533 (2/2) Beta-galactosidase C-terminal domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF02449 (2/2) Beta-galactosidase
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_7846 169.66 +- 73.88 6 0 0 0 0.14 +- 0.19 6 11

TIGR02937 (6/6) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (6/6) virulence factor Mce family protein
PF13406 (6/6) Transglycosylase SLT domain
PF11887 (6/6) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (6/6) Sigma-70, region 4
PF04542 (6/6) Sigma-70 region 2
PF02470 (6/6) MlaD protein
PF02405 (6/6) Permease MlaE
PF00005 (6/6) ABC transporter
PF16859 (5/6) Tetracyclin repressor-like, C-terminal domain
PF00440 (5/6) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_8113 28.26 +- 0.00 3 0 0 3 0.18 +- 0.29 3 13

TIGR04187 (3/3) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (3/3) putative ATP-grasp target RiPP
TIGR00724 (3/3) biotin-dependent carboxylase uncharacterized domain
PF14404 (3/3) Ribosomally synthesized peptide in Streptomyces species
PF08242 (3/3) Methyltransferase domain
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF07286 (3/3) Protein of unknown function (DUF1445)
PF03746 (3/3) LamB/YcsF family
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_27945 327.90 +- 26.85 2 0 2 2 0.01 +- 0.01 2 11

TIGR04085 (2/2) radical SAM additional 4Fe4S-binding SPASM domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF14518 (2/2) Iron-containing redox enzyme
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01048 (2/2) Phosphorylase superfamily
precursor_jaccard_groups_15059 324.00 +- 66.00 2 0 0 0 0.01 +- 0.00 2 3

PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_3576 95.62 +- 81.92 5 0 0 0 0.10 +- 0.26 5 5

TIGR01840 (5/5) esterase, PHB depolymerase family
TIGR00666 (5/5) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (5/5) Protein of unknown function (DUF4232)
PF10503 (5/5) Esterase PHB depolymerase
PF02113 (5/5) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_jaccard_groups_9972 200.05 +- 54.78 5 0 5 0 0.02 +- 0.01 5 8

PF11639 (5/5) REDY-like protein HapK
PF03704 (5/5) Bacterial transcriptional activator domain
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_27496 136.44 +- 123.56 2 0 0 0 0.08 +- 0.15 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09286 (2/2) Pro-kumamolisin, activation domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_41194 1573.84 +- 732.99 2 0 2 0 0.02 +- 0.03 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01214 (2/2) dTDP-4-dehydrorhamnose reductase
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16861 (2/2) Carbamoyltransferase C-terminus
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF08484 (2/2) C-methyltransferase C-terminal domain
PF08421 (2/2) Putative zinc binding domain
PF06722 (2/2) Protein of unknown function (DUF1205)
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04321 (2/2) RmlD substrate binding domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02195 (2/2) ParB-like nuclease domain
PF02153 (2/2) Prephenate dehydrogenase
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_42140 13.34 +- 0.00 2 0 0 0 0.15 +- 0.18 2 3

PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF06224 (2/2) Winged helix DNA-binding domain
PF03176 (2/2) MMPL family
precursor_jaccard_groups_41190 61.85 +- 44.39 2 0 0 0 0.10 +- 0.26 2 6

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13459 (2/2) 4Fe-4S single cluster domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF07681 (1/2) DoxX
precursor_jaccard_groups_16021 149.78 +- 122.74 3 0 3 0 0.06 +- 0.05 3 7

PF13563 (3/3) 2'-5' RNA ligase superfamily
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00535 (3/3) Glycosyl transferase family 2
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_27167 174.91 +- 6.68 2 0 0 0 0.06 +- 0.05 2 11

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_20940 51.44 +- 11.85 3 0 0 0 0.06 +- 0.06 3 6

PF17801 (3/3) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (3/3) Alpha galactosidase A
PF04616 (3/3) Glycosyl hydrolases family 43
PF01794 (3/3) Ferric reductase like transmembrane component
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_10347 509.20 +- 160.90 4 0 1 0 0.05 +- 0.18 4 11

PF17914 (4/4) HopA1 effector protein family
PF02897 (4/4) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02441 (4/4) Flavoprotein
PF01636 (4/4) Phosphotransferase enzyme family
PF00326 (4/4) Prolyl oligopeptidase family
PF00296 (4/4) Luciferase-like monooxygenase
PF07730 (2/4) Histidine kinase
PF01061 (2/4) ABC-2 type transporter
PF00196 (2/4) Bacterial regulatory proteins, luxR family
PF00072 (2/4) Response regulator receiver domain
PF00005 (2/4) ABC transporter
precursor_jaccard_groups_20910 422.22 +- 203.82 3 0 3 0 0.03 +- 0.03 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF13350 (3/3) Tyrosine phosphatase family
PF02543 (3/3) Carbamoyltransferase N-terminus
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_22063 1676.81 +- 761.48 3 0 0 0 0.01 +- 0.01 3 4

PF07811 (3/3) TadE-like protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF08666 (2/3) SAF domain
precursor_jaccard_groups_27010 121.89 +- 25.99 2 0 1 0 0.13 +- 0.17 2 14

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF03713 (2/2) Domain of unknown function (DUF305)
PF00877 (2/2) NlpC/P60 family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter
PF00146 (2/2) NADH dehydrogenase
PF00067 (2/2) Cytochrome P450
TIGR01085 (1/2) UDP-N-acetylmuramyl-tripeptide synthetase
PF08245 (1/2) Mur ligase middle domain
PF02875 (1/2) Mur ligase family, glutamate ligase domain
PF02342 (1/2) TerD domain
precursor_jaccard_groups_27011 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 10

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03621 (2/2) MbtH-like protein
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_20917 37.34 +- 1.17 3 0 0 0 0.11 +- 0.10 3 4

PF11512 (3/3) Agrobacterium tumefaciens protein Atu4866
PF07702 (3/3) UTRA domain
PF07690 (3/3) Major Facilitator Superfamily
PF01979 (3/3) Amidohydrolase family
precursor_jaccard_groups_26783 35.46 +- 0.40 2 0 0 0 0.11 +- 0.18 2 5

PF11239 (2/2) Protein of unknown function (DUF3040)
PF07690 (2/2) Major Facilitator Superfamily
PF04203 (2/2) Sortase domain
PF02610 (2/2) L-arabinose isomerase
PF00999 (2/2) Sodium/hydrogen exchanger family
precursor_jaccard_groups_8284 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_jaccard_groups_18885 501.48 +- 176.56 3 0 3 3 0.02 +- 0.01 3 7

PF16861 (3/3) Carbamoyltransferase C-terminus
PF12840 (3/3) Helix-turn-helix domain
PF04055 (3/3) Radical SAM superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
PF01546 (3/3) Peptidase family M20/M25/M40
PF00891 (3/3) O-methyltransferase domain
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_11212 112.82 +- 35.81 3 0 0 0 0.06 +- 0.09 3 5

TIGR01979 (3/3) cysteine desulfurase, SufS family
PF03466 (3/3) LysR substrate binding domain
PF00266 (3/3) Aminotransferase class-V
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
PF00027 (3/3) Cyclic nucleotide-binding domain
precursor_jaccard_groups_26788 18.05 +- 3.85 2 0 1 0 0.14 +- 0.11 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF11991 (1/2) Tryptophan dimethylallyltransferase
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_11214 120.32 +- 107.16 3 0 0 0 0.06 +- 0.08 3 4

TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03919 (3/3) type VII secretion protein EccB
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_16151 30.29 +- 8.88 3 0 0 0 0.08 +- 0.09 3 2

PF01425 (3/3) Amidase
PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_30565 83.01 +- 1.06 2 0 0 0 0.14 +- 0.07 2 14

TIGR03356 (2/2) beta-galactosidase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF03160 (2/2) Calx-beta domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_8027 47.65 +- 40.64 6 0 4 0 0.15 +- 0.29 6 13

PF13977 (6/6) BetI-type transcriptional repressor, C-terminal
PF13607 (6/6) Succinyl-CoA ligase like flavodoxin domain
PF13549 (6/6) ATP-grasp domain
PF13459 (6/6) 4Fe-4S single cluster domain
PF13380 (6/6) CoA binding domain
PF10589 (6/6) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (6/6) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_22209 108.16 +- 66.81 3 0 0 0 0.06 +- 0.08 3 2

PF02515 (3/3) CoA-transferase family III
PF01636 (3/3) Phosphotransferase enzyme family
precursor_jaccard_groups_37342 31.52 +- 8.48 2 0 0 0 0.11 +- 0.10 2 5

PF13377 (2/2) Periplasmic binding protein-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF05448 (2/2) Acetyl xylan esterase (AXE1)
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF02515 (1/2) CoA-transferase family III
precursor_jaccard_groups_16791 119.28 +- 22.53 2 0 0 0 0.02 +- 0.02 2 3

PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
PF08877 (1/2) MepB protein
precursor_jaccard_groups_25896 244.34 +- 99.66 2 0 0 0 0.06 +- 0.03 2 15

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08448 (2/2) PAS fold
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_577 56.85 +- 43.15 2 0 0 0 0.18 +- 0.31 2 17

TIGR03934 (2/2) TQXA domain
PF08341 (2/2) Thioester domain
PF05506 (2/2) Domain of unknown function (DUF756)
PF00436 (2/2) Single-strand binding protein family
TIGR03719 (1/2) ATP-binding cassette protein, ChvD family
PF17032 (1/2) zinc-ribbon family
PF12848 (1/2) ABC transporter
PF12728 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF10824 (1/2) Excreted virulence factor EspC, type VII ESX diderm
PF06259 (1/2) Alpha/beta hydrolase
PF05122 (1/2) Mobile element transfer protein
PF03061 (1/2) Thioesterase superfamily
PF01926 (1/2) 50S ribosome-binding GTPase
PF01580 (1/2) FtsK/SpoIIIE family
PF00350 (1/2) Dynamin family
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_26941 554.14 +- 219.86 2 0 2 0 0.02 +- 0.02 2 6

PF16861 (2/2) Carbamoyltransferase C-terminus
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_12275 58.19 +- 22.03 3 0 3 0 0.06 +- 0.10 3 6

TIGR02426 (3/3) 3-carboxy-cis,cis-muconate cycloisomerase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13454 (3/3) FAD-NAD(P)-binding
PF10397 (3/3) Adenylosuccinate lyase C-terminus
PF01474 (3/3) Class-II DAHP synthetase family
PF00206 (3/3) Lyase
precursor_jaccard_groups_21263 153.33 +- 63.33 2 0 0 0 0.04 +- 0.03 2 11

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00775 (2/2) Dioxygenase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_25899 404.71 +- 25.29 2 0 0 0 0.02 +- 0.01 2 4

PF09084 (2/2) NMT1/THI5 like
PF01636 (2/2) Phosphotransferase enzyme family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26762 27.50 +- 0.81 2 0 0 0 0.11 +- 0.21 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_37299 1068.75 +- 101.25 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7030 106.22 +- 42.36 2 0 2 2 0.05 +- 0.07 2 8

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05977 (2/2) Transmembrane secretion effector
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03466 (2/2) LysR substrate binding domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_13874 69.42 +- 0.31 2 0 2 0 0.14 +- 0.13 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_38503 226.79 +- 6.54 2 0 0 0 0.04 +- 0.02 2 12

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13377 (2/2) Periplasmic binding protein-like domain
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF07282 (2/2) Putative transposase DNA-binding domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_25946 18.14 +- 6.05 2 0 0 0 0.14 +- 0.07 2 4

PF14759 (2/2) Reductase C-terminal
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
precursor_jaccard_groups_36749 120.91 +- 40.81 2 0 2 0 0.17 +- 0.23 2 12

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00704 (2/2) Glycosyl hydrolases family 18
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00722 (1/2) Glycosyl hydrolases family 16
PF00459 (1/2) Inositol monophosphatase family
precursor_jaccard_groups_11762 156.11 +- 33.87 4 0 0 0 0.01 +- 0.02 4 1

PF00348 (4/4) Polyprenyl synthetase
precursor_jaccard_groups_17774 35.33 +- 9.33 2 0 2 0 0.09 +- 0.03 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF00155 (1/2) Aminotransferase class I and II
precursor_jaccard_groups_21644 153.45 +- 58.75 3 0 0 0 0.02 +- 0.02 3 2

PF04326 (3/3) Putative DNA-binding domain
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_22519 284.94 +- 150.47 3 0 3 0 0.04 +- 0.04 3 11

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
TIGR00414 (3/3) serine--tRNA ligase
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03972 (3/3) MmgE/PrpD family
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00587 (3/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (3/3) Phosphopantetheine attachment site
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_22845 260.00 +- 0.00 3 0 0 0 0.01 +- 0.00 3 2

PF01738 (3/3) Dienelactone hydrolase family
PF00069 (3/3) Protein kinase domain
precursor_jaccard_groups_44459 344.00 +- 0.00 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_15931 299.34 +- 37.85 3 0 0 0 0.05 +- 0.05 3 12

PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08757 (3/3) CotH kinase protein
PF04138 (3/3) GtrA-like protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00672 (3/3) HAMP domain
PF00535 (3/3) Glycosyl transferase family 2
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF16316 (2/3) Domain of unknown function (DUF4956)
PF09359 (2/3) VTC domain
precursor_jaccard_groups_22512 351.80 +- 235.05 3 0 3 0 0.07 +- 0.23 3 7

PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF03949 (3/3) Malic enzyme, NAD binding domain
PF00975 (3/3) Thioesterase domain
PF00390 (3/3) Malic enzyme, N-terminal domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_30980 12.48 +- 0.10 2 0 0 0 0.24 +- 0.04 2 6

TIGR01923 (2/2) O-succinylbenzoate-CoA ligase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04909 (2/2) Amidohydrolase
PF01575 (2/2) MaoC like domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_12843 59.94 +- 18.43 3 0 0 0 0.04 +- 0.03 3 2

PF08241 (3/3) Methyltransferase domain
PF03403 (3/3) Platelet-activating factor acetylhydrolase, isoform II
precursor_jaccard_groups_21082 14.11 +- 0.89 2 0 0 0 0.14 +- 0.19 2 2

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_jaccard_groups_370 29.61 +- 26.66 3 0 2 0 0.13 +- 0.13 3 2

PF06902 (3/3) Divergent 4Fe-4S mono-cluster
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_26167 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_1136 12.32 +- 7.39 8 0 0 0 0.21 +- 0.22 8 6

TIGR01488 (8/8) HAD phosphoserine phosphatase-like hydrolase, family IB
PF12710 (8/8) haloacid dehalogenase-like hydrolase
PF01243 (8/8) Pyridoxamine 5'-phosphate oxidase
PF00970 (8/8) Oxidoreductase FAD-binding domain
PF00175 (8/8) Oxidoreductase NAD-binding domain
PF00042 (8/8) Globin
precursor_jaccard_groups_21797 653.79 +- 174.26 3 0 0 0 0.01 +- 0.00 3 9

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF12146 (3/3) Serine aminopeptidase, S33
PF03795 (3/3) YCII-related domain
PF03321 (3/3) GH3 auxin-responsive promoter
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_37507 67.71 +- 0.00 2 0 0 0 0.07 +- 0.02 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00667 (2/2) FAD binding domain
PF00258 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_5925 31.98 +- 4.01 4 0 0 0 0.13 +- 0.07 4 10

TIGR01217 (4/4) acetoacetate-CoA ligase
PF16177 (4/4) Acetyl-coenzyme A synthetase N-terminus
PF13564 (4/4) DoxX-like family
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (4/4) FAD binding domain
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (4/4) AMP-binding enzyme
PF13613 (2/4) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (2/4) DDE superfamily endonuclease
precursor_jaccard_groups_5433 30.93 +- 23.54 6 0 0 0 0.11 +- 0.06 6 4

PF03992 (6/6) Antibiotic biosynthesis monooxygenase
PF00294 (6/6) pfkB family carbohydrate kinase
PF08244 (4/6) Glycosyl hydrolases family 32 C terminal
PF00251 (4/6) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_8620 256.41 +- 148.97 4 0 0 0 0.06 +- 0.17 4 8

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (4/4) Major Facilitator Superfamily
PF03777 (4/4) ChpA-C
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12697 (2/4) Alpha/beta hydrolase family
PF00561 (2/4) alpha/beta hydrolase fold
precursor_jaccard_groups_5929 36.19 +- 0.00 2 0 0 0 0.25 +- 0.16 2 6

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF12708 (2/2) Pectate lyase superfamily protein
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_30186 232.44 +- 85.01 2 0 0 0 0.05 +- 0.04 2 19

PF13602 (2/2) Zinc-binding dehydrogenase
PF13546 (2/2) DDE superfamily endonuclease
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00501 (2/2) AMP-binding enzyme
PF00384 (2/2) Molybdopterin oxidoreductase
TIGR04316 (1/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF03358 (1/2) NADPH-dependent FMN reductase
PF01494 (1/2) FAD binding domain
PF01474 (1/2) Class-II DAHP synthetase family
PF00857 (1/2) Isochorismatase family
PF00425 (1/2) chorismate binding enzyme
PF00117 (1/2) Glutamine amidotransferase class-I
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_32210 252.10 +- 137.90 2 0 0 0 0.05 +- 0.03 2 4

PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_758 373.24 +- 294.60 8 0 8 8 0.02 +- 0.02 8 5

PF05147 (8/8) Lanthionine synthetase C-like protein
PF00005 (8/8) ABC transporter
PF00664 (7/8) ABC transporter transmembrane region
PF01636 (5/8) Phosphotransferase enzyme family
PF01593 (5/8) Flavin containing amine oxidoreductase
precursor_jaccard_groups_683 20.67 +- 3.14 2 0 0 0 0.10 +- 0.12 2 1

PF03780 (2/2) Asp23 family, cell envelope-related function
precursor_jaccard_groups_44702 33.88 +- 2.23 2 0 0 0 0.15 +- 0.32 2 10

TIGR01935 (2/2) RraA family
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF04332 (2/2) Protein of unknown function (DUF475)
PF03737 (2/2) Aldolase/RraA
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
precursor_jaccard_groups_20131 80.99 +- 41.36 3 0 3 0 0.08 +- 0.18 3 9

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03567 (3/3) FMN reductase
TIGR01208 (3/3) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/3) dTDP-glucose 4,6-dehydratase
PF16363 (3/3) GDP-mannose 4,6 dehydratase
PF03358 (3/3) NADPH-dependent FMN reductase
PF01494 (3/3) FAD binding domain
PF00483 (3/3) Nucleotidyl transferase
PF00296 (3/3) Luciferase-like monooxygenase
precursor_jaccard_groups_6827 77.49 +- 30.09 7 0 0 0 0.12 +- 0.16 7 7

TIGR00996 (7/7) virulence factor Mce family protein
PF11887 (7/7) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (7/7) MlaD protein
PF02405 (7/7) Permease MlaE
PF00005 (7/7) ABC transporter
PF13406 (6/7) Transglycosylase SLT domain
PF07228 (4/7) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_3570 562.44 +- 521.84 6 0 0 0 0.05 +- 0.11 6 7

PF13407 (6/6) Periplasmic binding protein domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00294 (6/6) pfkB family carbohydrate kinase
PF00005 (6/6) ABC transporter
PF05025 (5/6) RbsD / FucU transport protein family
precursor_jaccard_groups_16826 21.14 +- 4.66 2 0 2 0 0.15 +- 0.32 2 6

PF13560 (2/2) Helix-turn-helix domain
PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF06259 (2/2) Alpha/beta hydrolase
PF05362 (2/2) Lon protease (S16) C-terminal proteolytic domain
PF04149 (2/2) Domain of unknown function (DUF397)
precursor_jaccard_groups_208 76.72 +- 60.49 18 0 16 0 0.09 +- 0.15 18 2

PF13370 (18/18) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (18/18) Cytochrome P450
precursor_jaccard_groups_757 93.35 +- 55.18 7 0 1 0 0.20 +- 0.25 7 9

PF13454 (7/7) FAD-NAD(P)-binding
PF02983 (7/7) Alpha-lytic protease prodomain
PF00296 (7/7) Luciferase-like monooxygenase
PF00089 (7/7) Trypsin
TIGR03860 (6/7) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07920 (6/7) Protein of unknown function (DUF1684)
TIGR01726 (5/7) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00528 (5/7) Binding-protein-dependent transport system inner membrane component
PF00005 (5/7) ABC transporter
precursor_jaccard_groups_20139 49.03 +- 24.00 3 0 0 0 0.18 +- 0.14 3 10

PF16353 (3/3) Domain of unknown function(DUF4981)
PF13412 (3/3) Winged helix-turn-helix DNA-binding
PF04030 (3/3) D-arabinono-1,4-lactone oxidase
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (3/3) FAD binding domain
PF00480 (3/3) ROK family
PF00652 (2/3) Ricin-type beta-trefoil lectin domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_194 23.28 +- 9.65 8 0 0 8 0.16 +- 0.19 8 6

TIGR04187 (8/8) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (8/8) putative ATP-grasp target RiPP
PF14404 (8/8) Ribosomally synthesized peptide in Streptomyces species
PF08242 (6/8) Methyltransferase domain
PF00903 (6/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00723 (4/8) Glycosyl hydrolases family 15
precursor_jaccard_groups_29343 55.11 +- 5.59 2 0 0 0 0.04 +- 0.04 2 5

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_11500 489.58 +- 228.23 3 0 0 0 0.01 +- 0.01 3 5

PF12704 (3/3) MacB-like periplasmic core domain
PF11350 (3/3) Protein of unknown function (DUF3152)
PF02687 (3/3) FtsX-like permease family
PF01471 (3/3) Putative peptidoglycan binding domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_34200 73.15 +- 4.85 2 0 0 0 0.04 +- 0.03 2 4

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_40480 93.75 +- 3.75 2 0 0 0 0.03 +- 0.03 2 4

TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_1962 74.91 +- 45.23 16 0 0 0 0.07 +- 0.04 16 6

TIGR04538 (16/16) cytochrome P450, cyclodipeptide synthase-associated
PF09339 (16/16) IclR helix-turn-helix domain
PF03055 (16/16) Retinal pigment epithelial membrane protein
PF01614 (16/16) Bacterial transcriptional regulator
PF00067 (16/16) Cytochrome P450
PF12680 (10/16) SnoaL-like domain
precursor_jaccard_groups_44581 387.50 +- 257.50 2 0 2 0 0.02 +- 0.01 2 5

PF13523 (2/2) Acetyltransferase (GNAT) domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF04183 (2/2) IucA / IucC family
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
precursor_jaccard_groups_45507 296.25 +- 93.75 2 0 0 0 0.03 +- 0.07 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
TIGR03919 (1/2) type VII secretion protein EccB
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
precursor_jaccard_groups_30851 390.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03589 (2/2) UDP-N-acetylglucosamine 4,6-dehydratase (inverting)
TIGR02246 (2/2) conserved hypothetical protein
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF02719 (2/2) Polysaccharide biosynthesis protein
PF01425 (2/2) Amidase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_29503 177.61 +- 4.56 2 0 0 0 0.12 +- 0.29 2 11

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03479 (2/2) Plants and Prokaryotes Conserved (PCC) domain
PF02803 (2/2) Thiolase, C-terminal domain
PF01061 (2/2) ABC-2 type transporter
PF00501 (2/2) AMP-binding enzyme
PF00376 (2/2) MerR family regulatory protein
PF00108 (2/2) Thiolase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_29506 390.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 4

PF05147 (2/2) Lanthionine synthetase C-like protein
PF04055 (2/2) Radical SAM superfamily
PF00106 (1/2) short chain dehydrogenase
PF00069 (1/2) Protein kinase domain
precursor_jaccard_groups_44055 1163.94 +- 693.66 2 0 0 0 0.02 +- 0.01 2 18

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28323 58.18 +- 2.13 2 0 0 0 0.15 +- 0.08 2 8

PF07969 (2/2) Amidohydrolase family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF01047 (2/2) MarR family
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_32564 91.82 +- 55.61 2 0 0 0 0.07 +- 0.06 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01301 (2/2) Glycosyl hydrolases family 35
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_11927 20.99 +- 0.84 4 0 0 0 0.14 +- 0.21 4 8

TIGR01695 (4/4) murein biosynthesis integral membrane protein MurJ
PF03023 (4/4) Lipid II flippase MurJ
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_17359 61.08 +- 9.71 2 0 0 0 0.15 +- 0.29 2 9

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_11922 54.52 +- 20.40 4 0 0 0 0.04 +- 0.02 4 3

PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF00501 (4/4) AMP-binding enzyme
PF00221 (4/4) Aromatic amino acid lyase
precursor_jaccard_groups_17422 335.05 +- 152.51 3 0 0 0 0.04 +- 0.04 3 7

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF04909 (3/3) Amidohydrolase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00248 (3/3) Aldo/keto reductase family
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_14198 129.33 +- 90.98 3 0 3 0 0.02 +- 0.02 3 2

PF00583 (3/3) Acetyltransferase (GNAT) family
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_44908 1295.00 +- 5.00 2 0 0 2 0.01 +- 0.00 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF13360 (2/2) PQQ-like domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_4380 228.03 +- 86.61 9 0 0 0 0.02 +- 0.01 9 6

TIGR03930 (9/9) WXG100 family type VII secretion target
TIGR03921 (9/9) type VII secretion-associated serine protease mycosin
TIGR03919 (9/9) type VII secretion protein EccB
PF06013 (9/9) Proteins of 100 residues with WXG
PF05108 (9/9) Type VII secretion system ESX-1, transport TM domain B
PF00082 (9/9) Subtilase family
precursor_jaccard_groups_32358 29.57 +- 2.68 2 0 2 0 0.10 +- 0.21 2 6

TIGR00040 (2/2) phosphodiesterase, MJ0936 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12850 (2/2) Calcineurin-like phosphoesterase superfamily domain
PF12802 (2/2) MarR family
PF05257 (2/2) CHAP domain
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_4094 213.07 +- 45.29 7 0 7 0 0.01 +- 0.00 7 3

TIGR02050 (7/7) carboxylate-amine ligase, YbdK family
PF09860 (7/7) Uncharacterized protein conserved in bacteria (DUF2087)
PF04107 (7/7) Glutamate-cysteine ligase family 2(GCS2)
precursor_jaccard_groups_40647 758.33 +- 411.67 2 0 0 2 0.03 +- 0.08 2 10

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08007 (2/2) Cupin superfamily protein
PF06182 (2/2) ABC-2 family transporter protein
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02373 (2/2) JmjC domain, hydroxylase
PF00491 (2/2) Arginase family
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
PF18029 (1/2) Glyoxalase-like domain
precursor_jaccard_groups_28743 27.97 +- 5.94 2 0 0 0 0.14 +- 0.26 2 24

TIGR02548 (2/2) CRISPR type I-E/ECOLI-associated protein CasB/Cse2
TIGR02547 (2/2) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
TIGR01907 (2/2) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
TIGR01873 (2/2) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
TIGR01869 (2/2) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
TIGR01868 (2/2) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
TIGR01596 (2/2) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (2/2) CRISPR-associated helicase Cas3
PF18395 (2/2) Cas3 C-terminal domain
PF18019 (2/2) HD domain
PF09707 (2/2) CRISPR-associated protein (Cas_Cas2CT1978)
PF09704 (2/2) CRISPR-associated protein (Cas_Cas5)
PF09485 (2/2) CRISPR-associated protein Cse2 (CRISPR_cse2)
PF09481 (2/2) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF09344 (2/2) CT1975-like protein
PF08798 (2/2) CRISPR associated protein
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF05685 (2/2) Putative restriction endonuclease
TIGR03638 (1/2) CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI
TIGR02980 (1/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04539 (1/2) Sigma-70 region 3
PF01867 (1/2) CRISPR associated protein Cas1
precursor_jaccard_groups_9562 35.83 +- 1.34 4 0 0 0 0.20 +- 0.22 4 9

PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/4) Major Facilitator Superfamily
PF05544 (4/4) Proline racemase
PF04324 (4/4) BFD-like [2Fe-2S] binding domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01494 (4/4) FAD binding domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00701 (4/4) Dihydrodipicolinate synthetase family
precursor_jaccard_groups_35166 177.75 +- 80.25 2 0 0 0 0.02 +- 0.03 2 6

PF03777 (2/2) ChpA-C
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13285 (1/2) Domain of unknown function (DUF4073)
PF00149 (1/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_9115 92.33 +- 61.75 2 0 0 0 0.08 +- 0.15 2 9

PF14606 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF06580 (2/2) Histidine kinase
PF04397 (2/2) LytTr DNA-binding domain
PF03640 (2/2) Secreted repeat of unknown function
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00474 (2/2) Sodium:solute symporter family
PF00296 (2/2) Luciferase-like monooxygenase
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_4897 221.77 +- 79.53 9 0 0 0 0.05 +- 0.04 9 10

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_17197 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_44634 27.91 +- 1.53 2 0 2 0 0.20 +- 0.24 2 22

TIGR03346 (2/2) ATP-dependent chaperone protein ClpB
TIGR02350 (2/2) chaperone protein DnaK
TIGR01068 (2/2) thioredoxin
PF17871 (2/2) AAA lid domain
PF13591 (2/2) MerR HTH family regulatory protein
PF13515 (2/2) Fusaric acid resistance protein-like
PF12805 (2/2) FUSC-like inner membrane protein yccS
PF10590 (2/2) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF01556 (2/2) DnaJ C terminal domain
PF01025 (2/2) GrpE
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00226 (2/2) DnaJ domain
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00012 (2/2) Hsp70 protein
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
PF08241 (1/2) Methyltransferase domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_6247 41.95 +- 36.10 5 0 0 0 0.11 +- 0.13 5 2

PF13649 (5/5) Methyltransferase domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
precursor_jaccard_groups_18223 59.58 +- 26.33 3 0 3 0 0.04 +- 0.03 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12840 (3/3) Helix-turn-helix domain
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_40864 94.50 +- 34.50 2 0 0 0 0.04 +- 0.04 2 6

PF13492 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_34880 169.53 +- 20.58 2 0 0 2 0.08 +- 0.14 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05726 (2/2) Pirin C-terminal cupin domain
PF04055 (2/2) Radical SAM superfamily
PF02678 (2/2) Pirin
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_13205 44.14 +- 28.01 4 0 0 0 0.11 +- 0.10 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF04185 (4/4) Phosphoesterase family
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_31769 324.00 +- 66.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00491 (2/2) Arginase family
PF01636 (1/2) Phosphotransferase enzyme family
precursor_jaccard_groups_42243 713.00 +- 197.00 2 0 0 2 0.01 +- 0.00 2 10

TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13238 (2/2) AAA domain
PF04055 (2/2) Radical SAM superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_42244 46.80 +- 0.00 2 0 2 0 0.06 +- 0.07 2 5

TIGR00842 (2/2) transporter, betaine/carnitine/choline transporter (BCCT) family
PF13309 (2/2) HTH domain
PF08348 (2/2) YheO-like PAS domain
PF02028 (2/2) BCCT, betaine/carnitine/choline family transporter
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_42794 42.83 +- 2.12 2 0 0 0 0.24 +- 0.36 2 13

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00072 (2/2) Response regulator receiver domain
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08241 (1/2) Methyltransferase domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF00691 (1/2) OmpA family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_4876 14.43 +- 2.92 6 0 0 0 0.18 +- 0.33 6 8

TIGR00105 (6/6) ribosomal protein bL31
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF01756 (6/6) Acyl-CoA oxidase
PF01197 (6/6) Ribosomal protein L31
PF00583 (6/6) Acetyltransferase (GNAT) family
PF01497 (4/6) Periplasmic binding protein
PF01032 (4/6) FecCD transport family
PF00005 (4/6) ABC transporter
precursor_jaccard_groups_19205 637.66 +- 461.28 3 0 3 3 0.02 +- 0.02 3 15

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF17837 (3/3) 4'-phosphopantetheinyl transferase N-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12146 (3/3) Serine aminopeptidase, S33
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF05138 (3/3) Phenylacetic acid catabolic protein
PF04055 (3/3) Radical SAM superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_4874 140.36 +- 95.37 6 0 0 0 0.13 +- 0.26 6 10

TIGR01727 (6/6) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01266 (6/6) fumarylacetoacetase
PF12911 (6/6) N-terminal TM domain of oligopeptide transport permease C
PF09298 (6/6) Fumarylacetoacetase N-terminal
PF08352 (6/6) Oligopeptide/dipeptide transporter, C-terminal region
PF04209 (6/6) homogentisate 1,2-dioxygenase
PF01557 (6/6) Fumarylacetoacetate (FAA) hydrolase family
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00496 (6/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_43845 35.29 +- 4.71 2 0 0 0 0.06 +- 0.02 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07859 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_11692 142.42 +- 22.33 4 0 4 0 0.06 +- 0.17 4 19

TIGR02412 (4/4) aminopeptidase N
TIGR01686 (4/4) FkbH domain
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13535 (4/4) ATP-grasp domain
PF13434 (4/4) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (4/4) ERAP1-like C-terminal domain
PF09334 (4/4) tRNA synthetases class I (M)
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF02274 (4/4) Amidinotransferase
PF02195 (4/4) ParB-like nuclease domain
PF01433 (4/4) Peptidase family M1 domain
PF01266 (4/4) FAD dependent oxidoreductase
PF00999 (4/4) Sodium/hydrogen exchanger family
PF00550 (4/4) Phosphopantetheine attachment site
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
precursor_jaccard_groups_4870 1927.84 +- 1009.74 6 0 6 6 0.03 +- 0.14 6 5

PF05147 (6/6) Lanthionine synthetase C-like protein
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
PF02441 (5/6) Flavoprotein
PF00069 (5/6) Protein kinase domain
precursor_jaccard_groups_43846 21.82 +- 0.85 2 0 0 0 0.14 +- 0.11 2 4

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_7276 78.76 +- 24.44 2 0 2 0 0.06 +- 0.05 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13361 (2/2) UvrD-like helicase C-terminal domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_3716 72.46 +- 24.45 3 0 3 0 0.14 +- 0.12 3 8

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13377 (3/3) Periplasmic binding protein-like domain
PF08220 (3/3) DeoR-like helix-turn-helix domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (3/3) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_31168 212.96 +- 84.74 2 0 2 0 0.05 +- 0.07 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01510 (2/2) pantetheine-phosphate adenylyltransferase
PF13646 (2/2) HEAT repeats
PF13411 (2/2) MerR HTH family regulatory protein
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03176 (2/2) MMPL family
PF02310 (2/2) B12 binding domain
PF01467 (2/2) Cytidylyltransferase-like
PF00857 (2/2) Isochorismatase family
PF02607 (1/2) B12 binding domain
precursor_jaccard_groups_43205 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3719 74.09 +- 23.34 9 0 0 0 0.18 +- 0.22 9 16

TIGR01727 (9/9) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF03425 (9/9) Carbohydrate binding domain (family 11)
PF01915 (9/9) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (9/9) Glycosyl hydrolase family 3 N terminal domain
PF00232 (9/9) Glycosyl hydrolase family 1
PF00005 (9/9) ABC transporter
TIGR03356 (8/9) beta-galactosidase
PF13377 (8/9) Periplasmic binding protein-like domain
PF12911 (8/9) N-terminal TM domain of oligopeptide transport permease C
PF00528 (8/9) Binding-protein-dependent transport system inner membrane component
PF00496 (8/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF12833 (7/9) Helix-turn-helix domain
PF06445 (7/9) GyrI-like small molecule binding domain
PF00356 (7/9) Bacterial regulatory proteins, lacI family
PF03160 (5/9) Calx-beta domain
precursor_jaccard_groups_31163 238.88 +- 175.64 2 0 0 0 0.13 +- 0.27 2 21

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF08241 (2/2) Methyltransferase domain
PF07811 (2/2) TadE-like protein
PF01638 (2/2) HxlR-like helix-turn-helix
PF01580 (2/2) FtsK/SpoIIIE family
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03696 (1/2) RHS repeat-associated core domain
PF15575 (1/2) Immunity protein 49
PF13614 (1/2) AAA domain
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF10609 (1/2) NUBPL iron-transfer P-loop NTPase
PF03534 (1/2) Salmonella virulence plasmid 65kDa B protein
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_34400 138.27 +- 35.07 2 0 0 0 0.02 +- 0.01 2 4

PF01341 (2/2) Glycosyl hydrolases family 6
PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_17228 104.39 +- 47.28 2 0 1 0 0.23 +- 0.24 2 15

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (2/2) FCD domain
PF05544 (2/2) Proline racemase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00664 (2/2) ABC transporter transmembrane region
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
TIGR02431 (1/2) beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family
PF09339 (1/2) IclR helix-turn-helix domain
PF01614 (1/2) Bacterial transcriptional regulator
precursor_jaccard_groups_2627 156.67 +- 72.92 6 0 0 6 0.07 +- 0.18 6 10

TIGR04276 (6/6) FxsC C-terminal domain
TIGR04269 (6/6) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (6/6) FXSXX-COOH protein
TIGR04267 (6/6) HEXXH motif domain
PF13676 (6/6) TIR domain
PF13424 (6/6) Tetratricopeptide repeat
PF04055 (6/6) Radical SAM superfamily
PF01656 (6/6) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (6/6) NB-ARC domain
PF13374 (4/6) Tetratricopeptide repeat
precursor_jaccard_groups_25634 61.91 +- 6.59 2 0 2 0 0.16 +- 0.10 2 8

TIGR03356 (2/2) beta-galactosidase
PF13802 (2/2) Galactose mutarotase-like
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_25635 41.54 +- 12.88 2 0 0 0 0.08 +- 0.09 2 5

PF12833 (2/2) Helix-turn-helix domain
PF05685 (2/2) Putative restriction endonuclease
PF02311 (2/2) AraC-like ligand binding domain
PF00892 (2/2) EamA-like transporter family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_22362 25.15 +- 4.56 2 0 0 0 0.11 +- 0.13 2 4

PF09335 (2/2) SNARE associated Golgi protein
PF00248 (2/2) Aldo/keto reductase family
TIGR03395 (1/2) sphingomyelin phosphodiesterase
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
precursor_jaccard_groups_348 199.78 +- 243.07 6 0 1 6 0.10 +- 0.23 6 8

TIGR04188 (6/6) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (6/6) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (6/6) putative ATP-grasp target RiPP
PF14408 (6/6) Ribosomally synthesised peptide in actinomycetes
PF01135 (6/6) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13560 (4/6) Helix-turn-helix domain
PF13581 (3/6) Histidine kinase-like ATPase domain
PF04149 (3/6) Domain of unknown function (DUF397)
precursor_jaccard_groups_31344 218.91 +- 125.09 2 0 0 0 0.03 +- 0.02 2 7

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_10646 73.89 +- 8.30 2 0 0 0 0.12 +- 0.25 2 10

PF07811 (2/2) TadE-like protein
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03177 (1/2) Flp pilus assembly protein CpaB
PF16976 (1/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (1/2) AAA domain
PF08241 (1/2) Methyltransferase domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_4736 51.31 +- 23.16 6 0 0 0 0.12 +- 0.16 6 3

PF02515 (6/6) CoA-transferase family III
PF00082 (6/6) Subtilase family
PF05425 (5/6) Copper resistance protein D
precursor_jaccard_groups_10642 2728.16 +- 778.76 5 0 5 0 0.01 +- 0.01 5 16

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
PF13649 (5/5) Methyltransferase domain
PF13560 (5/5) Helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07993 (5/5) Male sterility protein
PF00977 (5/5) Histidine biosynthesis protein
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00155 (5/5) Aminotransferase class I and II
PF00107 (5/5) Zinc-binding dehydrogenase
PF13304 (4/5) AAA domain, putative AbiEii toxin, Type IV TA system
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00005 (4/5) ABC transporter
precursor_jaccard_groups_30 80.41 +- 55.68 72 0 53 0 0.19 +- 0.25 72 6

TIGR03797 (72/72) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (72/72) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF03412 (72/72) Peptidase C39 family
PF00664 (72/72) ABC transporter transmembrane region
PF00005 (72/72) ABC transporter
PF13437 (65/72) HlyD family secretion protein
precursor_jaccard_groups_31 39.52 +- 13.53 3 0 0 0 0.23 +- 0.39 3 7

TIGR01051 (3/3) DNA topoisomerase I
PF13368 (3/3) Topoisomerase C-terminal repeat
PF01751 (3/3) Toprim domain
PF01131 (3/3) DNA topoisomerase
TIGR00041 (2/3) dTMP kinase
PF05175 (2/3) Methyltransferase small domain
PF02223 (2/3) Thymidylate kinase
precursor_jaccard_groups_33 12.29 +- 4.25 5 0 1 0 0.19 +- 0.31 5 2

TIGR03445 (5/5) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF02585 (5/5) GlcNAc-PI de-N-acetylase
precursor_jaccard_groups_2534 167.61 +- 118.03 15 0 3 0 0.10 +- 0.09 15 6

PF09084 (15/15) NMT1/THI5 like
PF02668 (15/15) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF00005 (15/15) ABC transporter
TIGR03860 (8/15) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (8/15) Luciferase-like monooxygenase
precursor_jaccard_groups_36 78.70 +- 57.62 322 0 1 0 0.19 +- 0.31 322 11

PF00482 (321/322) Type II secretion system (T2SS), protein F
PF00437 (320/322) Type II/IV secretion system protein
PF07811 (319/322) TadE-like protein
PF00691 (311/322) OmpA family
TIGR03177 (309/322) Flp pilus assembly protein CpaB
PF16976 (309/322) Flp pilus assembly protein RcpC/CpaB
PF13400 (291/322) Putative Flp pilus-assembly TadE/G-like
PF13614 (280/322) AAA domain
PF00196 (251/322) Bacterial regulatory proteins, luxR family
PF00072 (251/322) Response regulator receiver domain
PF07730 (240/322) Histidine kinase
precursor_jaccard_groups_12869 22.21 +- 3.79 2 0 0 0 0.14 +- 0.22 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_14158 67.88 +- 54.90 4 0 0 0 0.10 +- 0.10 4 8

PF12697 (4/4) Alpha/beta hydrolase family
PF07045 (4/4) Domain of unknown function (DUF1330)
PF02036 (4/4) SCP-2 sterol transfer family
PF00175 (4/4) Oxidoreductase NAD-binding domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (4/4) short chain dehydrogenase
PF00037 (4/4) 4Fe-4S binding domain
PF00970 (2/4) Oxidoreductase FAD-binding domain
precursor_jaccard_groups_6018 407.14 +- 213.85 7 0 0 0 0.01 +- 0.00 7 6

PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF13535 (7/7) ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02955 (7/7) Prokaryotic glutathione synthetase, ATP-grasp domain
PF02222 (7/7) ATP-grasp domain
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_24455 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_18412 147.65 +- 42.12 3 0 0 0 0.03 +- 0.03 3 8

PF16951 (3/3) Putative methionine and alanine importer, small subunit
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (3/3) Glycosyl transferase family 2
PF00534 (3/3) Glycosyl transferases group 1
PF00209 (3/3) Sodium:neurotransmitter symporter family
TIGR00842 (2/3) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02028 (2/3) BCCT, betaine/carnitine/choline family transporter
PF00085 (2/3) Thioredoxin
precursor_jaccard_groups_11740 76.72 +- 70.53 4 0 0 0 0.13 +- 0.27 4 8

TIGR00236 (4/4) UDP-N-acetylglucosamine 2-epimerase
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13517 (4/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF08031 (4/4) Berberine and berberine like
PF07690 (4/4) Major Facilitator Superfamily
PF02350 (4/4) UDP-N-acetylglucosamine 2-epimerase
PF01757 (4/4) Acyltransferase family
PF01565 (4/4) FAD binding domain
precursor_jaccard_groups_32588 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF11999 (2/2) Protein of unknown function (DUF3494)
PF05199 (2/2) GMC oxidoreductase
PF01833 (2/2) IPT/TIG domain
PF00732 (2/2) GMC oxidoreductase
precursor_jaccard_groups_35910 169.21 +- 53.65 2 0 0 0 0.04 +- 0.06 2 9

TIGR00481 (2/2) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF01161 (2/2) Phosphatidylethanolamine-binding protein
PF01042 (2/2) Endoribonuclease L-PSP
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_45095 777.00 +- 3.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_32584 106.50 +- 54.15 2 0 2 0 0.07 +- 0.21 2 10

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF13469 (2/2) Sulfotransferase family
PF12848 (2/2) ABC transporter
PF07883 (2/2) Cupin domain
PF07730 (2/2) Histidine kinase
PF04672 (2/2) S-adenosyl methyltransferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1944 31.05 +- 18.69 4 0 0 0 0.18 +- 0.28 4 11

TIGR00045 (4/4) glycerate kinase
PF02595 (4/4) Glycerate kinase family
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00939 (4/4) Sodium:sulfate symporter transmembrane region
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF12867 (3/4) DinB superfamily
PF07690 (3/4) Major Facilitator Superfamily
PF00144 (3/4) Beta-lactamase
precursor_jaccard_groups_7728 620.80 +- 206.61 5 0 0 0 0.01 +- 0.00 5 4

TIGR01473 (5/5) protoheme IX farnesyltransferase
PF04261 (5/5) Dyp-type peroxidase family
PF01040 (5/5) UbiA prenyltransferase family
TIGR01413 (3/5) Dyp-type peroxidase family
precursor_jaccard_groups_4527 336.23 +- 166.57 9 0 0 0 0.02 +- 0.01 9 6

TIGR03930 (9/9) WXG100 family type VII secretion target
TIGR03921 (9/9) type VII secretion-associated serine protease mycosin
PF06013 (9/9) Proteins of 100 residues with WXG
PF05108 (9/9) Type VII secretion system ESX-1, transport TM domain B
PF00082 (9/9) Subtilase family
TIGR03919 (8/9) type VII secretion protein EccB
precursor_jaccard_groups_9509 37.81 +- 13.01 4 0 0 0 0.06 +- 0.02 4 2

PF03780 (4/4) Asp23 family, cell envelope-related function
PF00795 (4/4) Carbon-nitrogen hydrolase
precursor_jaccard_groups_36240 24.72 +- 1.08 2 0 0 0 0.16 +- 0.23 2 9

TIGR01031 (2/2) ribosomal protein bL32
PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (2/2) Ribosomal L32p protein family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_13420 230.33 +- 112.90 3 0 3 0 0.02 +- 0.01 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF14226 (3/3) non-haem dioxygenase in morphine synthesis N-terminal
PF13483 (3/3) Beta-lactamase superfamily domain
PF07467 (3/3) Beta-lactamase inhibitor (BLIP)
PF04989 (3/3) Cephalosporin hydroxylase
PF03704 (3/3) Bacterial transcriptional activator domain
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF02543 (3/3) Carbamoyltransferase N-terminus
precursor_jaccard_groups_35628 167.40 +- 12.60 2 0 2 0 0.02 +- 0.01 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF03795 (2/2) YCII-related domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2445 19.36 +- 2.27 5 0 5 0 0.16 +- 0.14 5 6

PF03450 (5/5) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (5/5) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (5/5) [2Fe-2S] binding domain
PF01315 (5/5) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (5/5) FAD binding domain in molybdopterin dehydrogenase
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_35626 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 6

PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF02310 (2/2) B12 binding domain
PF01613 (2/2) Flavin reductase like domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_12916 280.00 +- 36.96 4 0 0 0 0.01 +- 0.00 4 4

PF13404 (4/4) AsnC-type helix-turn-helix domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF01037 (4/4) Lrp/AsnC ligand binding domain
PF00501 (4/4) AMP-binding enzyme
precursor_jaccard_groups_42421 282.30 +- 147.70 2 0 1 0 0.04 +- 0.06 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF02633 (2/2) Creatinine amidohydrolase
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00459 (1/2) Inositol monophosphatase family
precursor_jaccard_groups_42422 13.16 +- 3.61 2 0 0 0 0.16 +- 0.29 2 5

TIGR03707 (2/2) polyphosphate kinase 2
PF12724 (2/2) Flavodoxin domain
PF03976 (2/2) Polyphosphate kinase 2 (PPK2)
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_8969 63.44 +- 35.48 5 0 5 0 0.07 +- 0.05 5 8

PF14864 (5/5) Alkyl sulfatase C-terminal
PF14863 (5/5) Alkyl sulfatase dimerisation
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_37201 10.41 +- 2.17 2 0 2 0 0.20 +- 0.09 2 4

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF13489 (2/2) Methyltransferase domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_1433 18.55 +- 4.02 2 0 2 0 0.19 +- 0.24 2 9

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00537 (2/2) putative methylase
PF14518 (2/2) Iron-containing redox enzyme
PF09360 (2/2) Iron-binding zinc finger CDGSH type
PF07690 (2/2) Major Facilitator Superfamily
PF05175 (2/2) Methyltransferase small domain
PF02541 (2/2) Ppx/GppA phosphatase family
TIGR00377 (1/2) anti-anti-sigma factor
PF13466 (1/2) STAS domain
precursor_jaccard_groups_8961 21.44 +- 5.42 5 0 0 0 0.15 +- 0.06 5 5

TIGR02089 (5/5) tartrate dehydrogenase
PF03466 (5/5) LysR substrate binding domain
PF00202 (5/5) Aminotransferase class-III
PF00180 (5/5) Isocitrate/isopropylmalate dehydrogenase
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_8364 199.53 +- 41.27 4 0 4 0 0.02 +- 0.01 4 4

PF11468 (4/4) Aromatic prenyltransferase Orf2
PF04672 (4/4) S-adenosyl methyltransferase
PF03284 (4/4) Phenazine biosynthesis protein A/B
PF01494 (4/4) FAD binding domain
precursor_jaccard_groups_5461 61.84 +- 50.92 8 0 8 0 0.07 +- 0.04 8 3

PF00550 (8/8) Phosphopantetheine attachment site
PF00268 (8/8) Ribonucleotide reductase, small chain
PF00067 (8/8) Cytochrome P450
precursor_jaccard_groups_14422 41.63 +- 6.54 4 0 4 0 0.07 +- 0.09 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF00905 (4/4) Penicillin binding protein transpeptidase domain
PF00266 (4/4) Aminotransferase class-V
PF00171 (4/4) Aldehyde dehydrogenase family
PF13472 (2/4) GDSL-like Lipase/Acylhydrolase family
precursor_jaccard_groups_33297 75.47 +- 6.25 2 0 0 0 0.16 +- 0.28 2 8

PF07883 (2/2) Cupin domain
PF05995 (2/2) Cysteine dioxygenase type I
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF02018 (2/2) Carbohydrate binding domain
PF00704 (2/2) Glycosyl hydrolases family 18
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9180 31.74 +- 11.90 3 0 3 0 0.19 +- 0.30 3 19

TIGR02350 (3/3) chaperone protein DnaK
PF17765 (3/3) MmyB-like transcription regulator ligand binding domain
PF13560 (3/3) Helix-turn-helix domain
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF01025 (3/3) GrpE
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00067 (3/3) Cytochrome P450
PF00012 (3/3) Hsp70 protein
PF09129 (2/3) Cholesterol oxidase, substrate-binding
PF06386 (2/3) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/3) Gas vesicle synthesis protein GvpO
PF05121 (2/3) Gas vesicle protein K
PF05120 (2/3) Gas vesicle protein G
PF03364 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF02371 (2/3) Transposase IS116/IS110/IS902 family
PF01565 (2/3) FAD binding domain
PF01548 (2/3) Transposase
PF00741 (2/3) Gas vesicle protein
precursor_jaccard_groups_41103 272.17 +- 18.67 2 0 0 0 0.05 +- 0.07 2 9

PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02633 (2/2) Creatinine amidohydrolase
PF00754 (2/2) F5/8 type C domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
PF04149 (1/2) Domain of unknown function (DUF397)
precursor_jaccard_groups_19125 259.33 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
precursor_jaccard_groups_27828 93.93 +- 20.22 2 0 0 0 0.04 +- 0.07 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF01234 (2/2) NNMT/PNMT/TEMT family
PF01227 (2/2) GTP cyclohydrolase I
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_27799 645.00 +- 129.00 2 0 2 0 0.01 +- 0.01 2 12

PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00866 (2/2) Ring hydroxylating beta subunit
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_9219 67.32 +- 32.20 5 0 0 0 0.07 +- 0.06 5 8

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12833 (5/5) Helix-turn-helix domain
PF06719 (5/5) AraC-type transcriptional regulator N-terminus
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00171 (5/5) Aldehyde dehydrogenase family
precursor_jaccard_groups_4416 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_4417 37.42 +- 1.08 2 0 0 0 0.11 +- 0.06 2 4

PF08241 (2/2) Methyltransferase domain
PF05711 (2/2) Macrocin-O-methyltransferase (TylF)
PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_36027 744.50 +- 29.50 2 0 2 0 0.01 +- 0.00 2 12

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00040 (2/2) phosphodiesterase, MJ0936 family
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF12850 (2/2) Calcineurin-like phosphoesterase superfamily domain
PF04389 (2/2) Peptidase family M28
PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00334 (2/2) Nucleoside diphosphate kinase
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_4411 271.27 +- 101.13 8 0 0 0 0.04 +- 0.08 8 7

PF13649 (8/8) Methyltransferase domain
PF13520 (8/8) Amino acid permease
PF02668 (8/8) Taurine catabolism dioxygenase TauD, TfdA family
PF01636 (8/8) Phosphotransferase enzyme family
PF00293 (8/8) NUDIX domain
PF00120 (8/8) Glutamine synthetase, catalytic domain
PF00005 (8/8) ABC transporter
precursor_jaccard_groups_14462 129.88 +- 18.32 4 0 0 0 0.10 +- 0.07 4 16

PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
TIGR01182 (3/4) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (3/4) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (3/4) Alpha galactosidase A
precursor_jaccard_groups_33617 677.70 +- 428.02 2 0 2 0 0.02 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_984 60.01 +- 18.72 17 0 0 0 0.19 +- 0.31 17 10

TIGR03177 (17/17) Flp pilus assembly protein CpaB
PF16976 (17/17) Flp pilus assembly protein RcpC/CpaB
PF13614 (17/17) AAA domain
PF07811 (17/17) TadE-like protein
PF00482 (17/17) Type II secretion system (T2SS), protein F
PF00437 (17/17) Type II/IV secretion system protein
PF07730 (14/17) Histidine kinase
PF00196 (14/17) Bacterial regulatory proteins, luxR family
PF00072 (14/17) Response regulator receiver domain
PF00691 (12/17) OmpA family
precursor_jaccard_groups_19235 158.26 +- 16.25 3 0 0 0 0.08 +- 0.07 3 19

PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF06831 (3/3) Formamidopyrimidine-DNA glycosylase H2TH domain
PF06827 (3/3) Zinc finger found in FPG and IleRS
PF05425 (3/3) Copper resistance protein D
PF04234 (3/3) CopC domain
PF02449 (3/3) Beta-galactosidase
PF02342 (3/3) TerD domain
PF02065 (3/3) Melibiase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01149 (3/3) Formamidopyrimidine-DNA glycosylase N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00440 (3/3) Bacterial regulatory proteins, tetR family
TIGR00229 (2/3) PAS domain S-box protein
PF13581 (2/3) Histidine kinase-like ATPase domain
PF08448 (2/3) PAS fold
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF01590 (2/3) GAF domain
PF00989 (2/3) PAS fold
precursor_jaccard_groups_13733 21.71 +- 2.22 3 0 0 0 0.19 +- 0.13 3 10

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13247 (3/3) 4Fe-4S dicluster domain
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_jaccard_groups_981 254.69 +- 212.93 35 0 0 0 0.03 +- 0.03 35 10

TIGR03930 (35/35) WXG100 family type VII secretion target
TIGR03919 (35/35) type VII secretion protein EccB
PF06013 (35/35) Proteins of 100 residues with WXG
PF05108 (35/35) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (34/35) type VII secretion integral membrane protein EccD
PF08817 (33/35) WXG100 protein secretion system (Wss), protein YukD
PF02575 (33/35) YbaB/EbfC DNA-binding family
PF07179 (24/35) SseB protein N-terminal domain
PF00652 (24/35) Ricin-type beta-trefoil lectin domain
PF15644 (23/35) Papain fold toxin 1, glutamine deamidase
precursor_jaccard_groups_1387 353.21 +- 345.27 20 0 1 0 0.05 +- 0.07 20 15

PF16355 (20/20) Domain of unknown function (DUF4982)
PF14310 (20/20) Fibronectin type III-like domain
PF02837 (20/20) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (20/20) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (20/20) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (20/20) Glycosyl hydrolase family 3 N terminal domain
PF00703 (20/20) Glycosyl hydrolases family 2
PF18565 (19/20) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (19/20) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (19/20) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (19/20) Alpha-L-rhamnosidase N-terminal domain
PF05592 (19/20) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF07859 (18/20) alpha/beta hydrolase fold
PF00135 (15/20) Carboxylesterase family
PF00106 (13/20) short chain dehydrogenase
precursor_jaccard_groups_1386 68.06 +- 27.29 27 0 0 25 0.13 +- 0.24 27 14

TIGR00710 (27/27) drug resistance transporter, Bcr/CflA subfamily
PF12833 (27/27) Helix-turn-helix domain
PF07690 (27/27) Major Facilitator Superfamily
PF02195 (27/27) ParB-like nuclease domain
PF00291 (27/27) Pyridoxal-phosphate dependent enzyme
PF00132 (27/27) Bacterial transferase hexapeptide (six repeats)
PF00067 (27/27) Cytochrome P450
TIGR01536 (25/27) asparagine synthase (glutamine-hydrolyzing)
PF13537 (25/27) Glutamine amidotransferase domain
PF00733 (25/27) Asparagine synthase
PF05331 (14/27) Protein of unknown function (DUF742)
PF03259 (14/27) Roadblock/LC7 domain
PF03029 (14/27) Conserved hypothetical ATP binding protein
PF01590 (14/27) GAF domain
precursor_jaccard_groups_1419 89.38 +- 56.15 25 0 0 0 0.03 +- 0.02 25 2

PF01408 (25/25) Oxidoreductase family, NAD-binding Rossmann fold
PF00232 (25/25) Glycosyl hydrolase family 1
precursor_jaccard_groups_27319 12.19 +- 0.00 2 0 2 0 0.25 +- 0.32 2 4

PF07730 (2/2) Histidine kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_35828 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_27312 42.13 +- 0.00 2 0 2 0 0.21 +- 0.34 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13649 (2/2) Methyltransferase domain
PF13602 (2/2) Zinc-binding dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01039 (2/2) Carboxyl transferase domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_1389 21.81 +- 0.83 3 0 0 0 0.23 +- 0.26 3 8

PF13452 (3/3) N-terminal half of MaoC dehydratase
PF12172 (3/3) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08924 (3/3) Domain of unknown function (DUF1906)
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF01796 (3/3) DUF35 OB-fold domain, acyl-CoA-associated
PF01575 (3/3) MaoC like domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_9984 52.49 +- 4.89 4 0 0 0 0.17 +- 0.13 4 7

PF14498 (4/4) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (4/4) Bacterial extracellular solute-binding protein
PF08533 (4/4) Beta-galactosidase C-terminal domain
PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF01670 (4/4) Glycosyl hydrolase family 12
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_8100 129.00 +- 0.00 6 0 6 0 0.02 +- 0.00 6 2

PF03972 (6/6) MmgE/PrpD family
PF00781 (6/6) Diacylglycerol kinase catalytic domain
precursor_jaccard_groups_41324 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00464 (2/2) Serine hydroxymethyltransferase
precursor_jaccard_groups_37196 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 3

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_30402 199.67 +- 32.53 2 0 0 0 0.02 +- 0.01 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_4933 164.75 +- 125.50 2 0 0 0 0.06 +- 0.13 2 6

TIGR02434 (2/2) precorrin-6A synthase (deacetylating)
PF03745 (2/2) Domain of unknown function (DUF309)
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_22676 588.49 +- 181.86 3 0 3 2 0.02 +- 0.02 3 17

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02195 (3/3) ParB-like nuclease domain
PF01266 (3/3) FAD dependent oxidoreductase
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
TIGR01536 (2/3) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/3) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/3) Glutamine amidotransferase domain
PF07690 (2/3) Major Facilitator Superfamily
PF00733 (2/3) Asparagine synthase
PF00067 (2/3) Cytochrome P450
precursor_jaccard_groups_12009 46.14 +- 7.07 4 0 0 0 0.11 +- 0.11 4 7

PF07728 (4/4) AAA domain (dynein-related subfamily)
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF00877 (4/4) NlpC/P60 family
PF00535 (4/4) Glycosyl transferase family 2
PF13586 (2/4) Transposase DDE domain
PF13340 (2/4) Putative transposase of IS4/5 family (DUF4096)
precursor_jaccard_groups_15662 29.05 +- 9.01 2 0 0 0 0.17 +- 0.33 2 5

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00082 (2/2) Subtilase family
PF05368 (1/2) NmrA-like family
PF01965 (1/2) DJ-1/PfpI family
precursor_jaccard_groups_39910 29.97 +- 0.36 2 0 0 0 0.23 +- 0.36 2 17

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
TIGR00655 (2/2) formyltetrahydrofolate deformylase
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13499 (2/2) EF-hand domain pair
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01435 (2/2) Peptidase family M48
PF01266 (2/2) FAD dependent oxidoreductase
PF00551 (2/2) Formyl transferase
PF00464 (2/2) Serine hydroxymethyltransferase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_16019 16.95 +- 6.10 3 0 0 0 0.16 +- 0.21 3 3

PF13309 (3/3) HTH domain
PF08348 (3/3) YheO-like PAS domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_12000 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family
precursor_jaccard_groups_12482 263.91 +- 86.58 4 0 4 0 0.02 +- 0.01 4 14

TIGR01733 (4/4) amino acid adenylation domain
PF18014 (4/4) Acetyltransferase (GNAT) domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF05199 (4/4) GMC oxidoreductase
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00975 (4/4) Thioesterase domain
PF00732 (4/4) GMC oxidoreductase
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_20904 130.92 +- 50.96 3 0 0 0 0.04 +- 0.03 3 5

PF09339 (3/3) IclR helix-turn-helix domain
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_14447 32.13 +- 5.78 3 0 0 0 0.06 +- 0.11 3 6

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF08386 (3/3) TAP-like protein
PF04149 (3/3) Domain of unknown function (DUF397)
PF02388 (3/3) FemAB family
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_20901 53.14 +- 8.71 3 0 0 0 0.04 +- 0.02 3 3

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00583 (3/3) Acetyltransferase (GNAT) family
precursor_jaccard_groups_1769 1139.56 +- 682.14 20 0 2 0 0.02 +- 0.01 20 6

PF08666 (20/20) SAF domain
PF07811 (20/20) TadE-like protein
PF01476 (20/20) LysM domain
PF00482 (20/20) Type II secretion system (T2SS), protein F
PF00437 (20/20) Type II/IV secretion system protein
PF13400 (19/20) Putative Flp pilus-assembly TadE/G-like
precursor_jaccard_groups_8290 98.30 +- 29.81 6 0 6 0 0.09 +- 0.27 6 13

TIGR01099 (6/6) UTP--glucose-1-phosphate uridylyltransferase
PF17914 (6/6) HopA1 effector protein family
PF13546 (6/6) DDE superfamily endonuclease
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF08028 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF02195 (6/6) ParB-like nuclease domain
PF01613 (6/6) Flavin reductase like domain
PF00982 (6/6) Glycosyltransferase family 20
PF00483 (6/6) Nucleotidyl transferase
PF00296 (6/6) Luciferase-like monooxygenase
PF02894 (5/6) Oxidoreductase family, C-terminal alpha/beta domain
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF01636 (4/6) Phosphotransferase enzyme family
precursor_jaccard_groups_3373 99.58 +- 20.33 11 0 0 0 0.16 +- 0.18 11 15

TIGR01727 (11/11) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00193 (11/11) urease, gamma subunit
PF13977 (11/11) BetI-type transcriptional repressor, C-terminal
PF08352 (11/11) Oligopeptide/dipeptide transporter, C-terminal region
PF04371 (11/11) Porphyromonas-type peptidyl-arginine deiminase
PF01979 (11/11) Amidohydrolase family
PF00699 (11/11) Urease beta subunit
PF00547 (11/11) Urease, gamma subunit
PF00528 (11/11) Binding-protein-dependent transport system inner membrane component
PF00496 (11/11) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00449 (11/11) Urease alpha-subunit, N-terminal domain
PF00440 (11/11) Bacterial regulatory proteins, tetR family
PF00005 (11/11) ABC transporter
PF12770 (9/11) CHAT domain
PF00069 (7/11) Protein kinase domain
precursor_jaccard_groups_1663 66.18 +- 15.16 16 0 0 0 0.19 +- 0.19 16 7

TIGR03860 (16/16) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (16/16) NMT1/THI5 like
PF02668 (16/16) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (16/16) Binding-protein-dependent transport system inner membrane component
PF00480 (16/16) ROK family
PF00296 (16/16) Luciferase-like monooxygenase
PF00005 (16/16) ABC transporter
precursor_jaccard_groups_8749 302.58 +- 85.92 4 0 2 4 0.01 +- 0.01 4 4

PF07690 (4/4) Major Facilitator Superfamily
PF04055 (4/4) Radical SAM superfamily
PF02897 (4/4) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (4/4) Prolyl oligopeptidase family
precursor_jaccard_groups_39824 207.91 +- 18.18 2 0 2 0 0.03 +- 0.05 2 8

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07730 (2/2) Histidine kinase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_5739 351.36 +- 105.56 4 0 1 0 0.01 +- 0.00 4 6

TIGR00574 (4/4) DNA ligase I, ATP-dependent (dnl1)
PF04679 (4/4) ATP dependent DNA ligase C terminal region
PF01068 (4/4) ATP dependent DNA ligase domain
PF00067 (4/4) Cytochrome P450
PF13459 (3/4) 4Fe-4S single cluster domain
PF04675 (2/4) DNA ligase N terminus
precursor_jaccard_groups_12137 208.00 +- 117.50 4 0 0 0 0.04 +- 0.06 4 13

PF18130 (4/4) ATP-grasp N-terminal domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF12307 (4/4) Protein of unknown function (DUF3631)
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF18603 (3/4) L-amino acid ligase C-terminal domain 2
PF17802 (3/4) Prealbumin-like fold domain
PF01555 (3/4) DNA methylase
PF00583 (3/4) Acetyltransferase (GNAT) family
TIGR01167 (2/4) LPXTG cell wall anchor domain
precursor_jaccard_groups_8740 39.11 +- 4.63 3 0 3 0 0.13 +- 0.22 3 9

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03621 (3/3) MbtH-like protein
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_5731 784.78 +- 333.12 8 0 0 0 0.02 +- 0.01 8 9

PF17765 (8/8) MmyB-like transcription regulator ligand binding domain
PF13560 (8/8) Helix-turn-helix domain
PF10935 (8/8) Protein of unknown function (DUF2637)
PF08666 (8/8) SAF domain
PF07811 (8/8) TadE-like protein
PF01476 (8/8) LysM domain
PF00753 (8/8) Metallo-beta-lactamase superfamily
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF00437 (8/8) Type II/IV secretion system protein
precursor_jaccard_groups_8032 148.02 +- 180.88 3 0 1 0 0.09 +- 0.12 3 7

PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF06439 (3/3) Domain of Unknown Function (DUF1080)
PF06283 (3/3) Trehalose utilisation
PF03422 (3/3) Carbohydrate binding module (family 6)
PF00801 (3/3) PKD domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00348 (2/3) Polyprenyl synthetase
precursor_jaccard_groups_21026 107.61 +- 33.61 3 0 0 0 0.03 +- 0.01 3 4

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_26974 541.67 +- 151.67 2 0 2 0 0.02 +- 0.03 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01123 (2/2) branched-chain amino acid aminotransferase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03621 (2/2) MbtH-like protein
PF02310 (2/2) B12 binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01425 (2/2) Amidase
PF01063 (2/2) Amino-transferase class IV
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00152 (2/2) tRNA synthetases class II (D, K and N)
precursor_jaccard_groups_3271 21.51 +- 9.89 9 0 3 0 0.14 +- 0.11 9 5

PF04324 (9/9) BFD-like [2Fe-2S] binding domain
PF02782 (9/9) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (9/9) FAD dependent oxidoreductase
PF00370 (9/9) FGGY family of carbohydrate kinases, N-terminal domain
PF07992 (7/9) Pyridine nucleotide-disulphide oxidoreductase
precursor_jaccard_groups_25888 10.58 +- 0.26 2 0 0 0 0.19 +- 0.25 2 3

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_29242 36.89 +- 13.11 2 0 0 0 0.09 +- 0.09 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_jaccard_groups_30571 1089.14 +- 716.86 2 0 2 0 0.02 +- 0.02 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17874 (2/2) MalT-like TPR region
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_13845 27.87 +- 5.97 2 0 0 0 0.15 +- 0.11 2 7

TIGR02286 (2/2) phenylacetic acid degradation protein PaaD
PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF17754 (1/2) MftR C-terminal domain
precursor_jaccard_groups_26379 23.69 +- 4.82 2 0 0 0 0.21 +- 0.35 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00178 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF03971 (2/2) Monomeric isocitrate dehydrogenase
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00248 (2/2) Aldo/keto reductase family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF07690 (1/2) Major Facilitator Superfamily
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_30977 61.88 +- 35.62 2 0 0 0 0.10 +- 0.11 2 7

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF07690 (2/2) Major Facilitator Superfamily
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00122 (2/2) E1-E2 ATPase
PF00877 (1/2) NlpC/P60 family
precursor_jaccard_groups_21413 9.26 +- 1.06 2 0 0 0 0.21 +- 0.08 2 2

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
precursor_jaccard_groups_37101 355.83 +- 229.17 2 0 0 0 0.03 +- 0.04 2 11

TIGR01296 (2/2) aspartate-semialdehyde dehydrogenase
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03466 (2/2) LysR substrate binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/2) B12 binding domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00892 (2/2) EamA-like transporter family
PF00696 (2/2) Amino acid kinase family
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_292 61.10 +- 21.01 2 0 0 0 0.21 +- 0.33 2 14

TIGR03535 (2/2) 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
PF17940 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14789 (2/2) Tetrahydrodipicolinate N-succinyltransferase middle
PF14602 (2/2) Hexapeptide repeat of succinyl-transferase
PF14019 (2/2) Protein of unknown function (DUF4235)
PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF18029 (1/2) Glyoxalase-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF00893 (1/2) Small Multidrug Resistance protein
precursor_jaccard_groups_25952 45.52 +- 4.74 2 0 0 0 0.17 +- 0.29 2 10

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF12840 (1/2) Helix-turn-helix domain
PF08327 (1/2) Activator of Hsp90 ATPase homolog 1-like protein
PF02602 (1/2) Uroporphyrinogen-III synthase HemD
PF01546 (1/2) Peptidase family M20/M25/M40
PF00486 (1/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_38750 30.01 +- 11.59 2 0 2 0 0.08 +- 0.13 2 5

PF18616 (2/2) CDI immunity proteins
PF18029 (2/2) Glyoxalase-like domain
PF13649 (2/2) Methyltransferase domain
PF06276 (2/2) Ferric iron reductase FhuF-like transporter
PF04183 (2/2) IucA / IucC family
precursor_jaccard_groups_25956 13.71 +- 0.11 2 0 0 0 0.22 +- 0.17 2 7

TIGR03723 (2/2) tRNA threonylcarbamoyl adenosine modification protein TsaD
TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
PF00814 (2/2) Glycoprotease family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_22508 595.10 +- 400.19 3 0 0 0 0.02 +- 0.02 3 8

TIGR00127 (3/3) isocitrate dehydrogenase, NADP-dependent
PF13343 (3/3) Bacterial extracellular solute-binding protein
PF12728 (3/3) Helix-turn-helix domain
PF08402 (3/3) TOBE domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00285 (3/3) Citrate synthase, C-terminal domain
PF00180 (3/3) Isocitrate/isopropylmalate dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_30997 15.00 +- 0.92 2 0 0 0 0.13 +- 0.01 2 5

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00455 (2/2) DeoR C terminal sensor domain
precursor_jaccard_groups_15922 26.42 +- 6.75 2 0 0 0 0.12 +- 0.10 2 4

PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_22857 286.45 +- 187.28 3 0 0 0 0.03 +- 0.05 3 12

TIGR00229 (3/3) PAS domain S-box protein
PF17203 (3/3) Single cache domain 3
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01590 (3/3) GAF domain
PF00989 (3/3) PAS fold
PF07969 (2/3) Amidohydrolase family
PF07729 (2/3) FCD domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_15927 48.87 +- 0.00 2 0 0 0 0.20 +- 0.39 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (2/2) argininosuccinate lyase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF07905 (2/2) Purine catabolism regulatory protein-like family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00491 (2/2) Arginase family
PF00206 (2/2) Lyase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32820 68.82 +- 37.20 2 0 0 0 0.14 +- 0.32 2 10

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00313 (2/2) 'Cold-shock' DNA-binding domain
TIGR02258 (1/2) 2'-5' RNA ligase
PF02834 (1/2) LigT like Phosphoesterase
PF01435 (1/2) Peptidase family M48
PF00857 (1/2) Isochorismatase family
PF00204 (1/2) DNA gyrase B
precursor_jaccard_groups_16349 53.01 +- 18.72 2 0 2 0 0.14 +- 0.13 2 9

PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF04954 (2/2) Siderophore-interacting protein
PF01497 (2/2) Periplasmic binding protein
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
TIGR03296 (1/2) M6 family metalloprotease domain
PF13828 (1/2) Domain of unknown function (DUF4190)
precursor_jaccard_groups_16345 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_30756 67.88 +- 28.88 2 0 0 0 0.04 +- 0.03 2 4

TIGR00120 (2/2) glutamate N-acetyltransferase/amino-acid acetyltransferase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01960 (2/2) ArgJ family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_16342 149.55 +- 64.04 3 0 0 0 0.04 +- 0.03 3 8

PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04972 (3/3) BON domain
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
PF00571 (3/3) CBS domain
PF13305 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_45256 199.98 +- 2.74 2 0 0 0 0.06 +- 0.09 2 11

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF13377 (2/2) Periplasmic binding protein-like domain
PF13205 (2/2) Bacterial Ig-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_11008 136.09 +- 58.85 3 0 0 0 0.13 +- 0.20 3 6

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (3/3) FAD-NAD(P)-binding
PF07920 (3/3) Protein of unknown function (DUF1684)
PF02983 (3/3) Alpha-lytic protease prodomain
PF00296 (3/3) Luciferase-like monooxygenase
PF00089 (3/3) Trypsin
precursor_jaccard_groups_11004 68.04 +- 37.39 4 0 0 0 0.04 +- 0.04 4 2

PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00877 (4/4) NlpC/P60 family
precursor_jaccard_groups_11002 712.24 +- 556.22 4 0 4 0 0.06 +- 0.18 4 11

TIGR01733 (4/4) amino acid adenylation domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10604 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_5426 555.78 +- 261.13 8 0 7 8 0.02 +- 0.02 8 16

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00778 (8/8) alkylhydroperoxidase AhpD family core domain
PF13454 (8/8) FAD-NAD(P)-binding
PF02896 (8/8) PEP-utilising enzyme, TIM barrel domain
PF02627 (8/8) Carboxymuconolactone decarboxylase family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (8/8) Pyridoxamine 5'-phosphate oxidase
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00005 (8/8) ABC transporter
TIGR01733 (7/8) amino acid adenylation domain
PF13193 (7/8) AMP-binding enzyme C-terminal domain
PF00550 (7/8) Phosphopantetheine attachment site
PF00501 (7/8) AMP-binding enzyme
PF00391 (5/8) PEP-utilising enzyme, mobile domain
precursor_jaccard_groups_29429 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase
precursor_jaccard_groups_19904 497.39 +- 308.50 3 0 3 0 0.03 +- 0.04 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_4474 39.00 +- 0.00 2 0 0 0 0.05 +- 0.03 2 2

PF05532 (2/2) CsbD-like
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_19901 139.87 +- 14.51 2 0 2 0 0.19 +- 0.23 2 39

TIGR03494 (2/2) salicylate synthase
TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00581 (2/2) Rhodanese-like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
TIGR01300 (1/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (1/2) Domain of unknown function (DUF4040)
PF07690 (1/2) Major Facilitator Superfamily
PF05331 (1/2) Protein of unknown function (DUF742)
PF04237 (1/2) YjbR
PF04066 (1/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (1/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03466 (1/2) LysR substrate binding domain
PF03334 (1/2) Na+/H+ antiporter subunit
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF01899 (1/2) Na+/H+ ion antiporter subunit
PF01590 (1/2) GAF domain
PF00662 (1/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/2) Proton-conducting membrane transporter
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_28917 69.23 +- 1.72 2 0 0 0 0.16 +- 0.27 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF04672 (2/2) S-adenosyl methyltransferase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00501 (2/2) AMP-binding enzyme
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_45460 603.67 +- 170.33 2 0 0 2 0.01 +- 0.00 2 5

PF13847 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF04055 (2/2) Radical SAM superfamily
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
precursor_jaccard_groups_22692 66.37 +- 10.89 3 0 0 0 0.17 +- 0.07 3 5

PF04909 (3/3) Amidohydrolase
PF04199 (3/3) Putative cyclase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_744 188.42 +- 114.77 39 0 39 0 0.04 +- 0.02 39 3

PF11991 (39/39) Tryptophan dimethylallyltransferase
PF07690 (39/39) Major Facilitator Superfamily
PF00155 (39/39) Aminotransferase class I and II
precursor_jaccard_groups_215 32.76 +- 4.10 2 0 0 0 0.06 +- 0.03 2 2

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_29779 146.25 +- 113.75 2 0 0 0 0.03 +- 0.05 2 2

PF10056 (2/2) Uncharacterized conserved protein (DUF2293)
PF08592 (2/2) Domain of unknown function (DUF1772)
precursor_jaccard_groups_211 56.73 +- 22.34 19 0 0 0 0.21 +- 0.29 19 10

PF12911 (19/19) N-terminal TM domain of oligopeptide transport permease C
PF11997 (19/19) Domain of unknown function (DUF3492)
PF08352 (19/19) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (19/19) Binding-protein-dependent transport system inner membrane component
PF00496 (19/19) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (19/19) ABC transporter
PF13692 (18/19) Glycosyl transferases group 1
PF11350 (18/19) Protein of unknown function (DUF3152)
PF12138 (13/19) Spherulation-specific family 4
PF01370 (13/19) NAD dependent epimerase/dehydratase family
precursor_jaccard_groups_210 24.01 +- 8.61 7 0 7 0 0.23 +- 0.32 7 7

PF07690 (7/7) Major Facilitator Superfamily
PF04140 (7/7) Isoprenylcysteine carboxyl methyltransferase (ICMT) family
PF02797 (7/7) Chalcone and stilbene synthases, C-terminal domain
PF01494 (7/7) FAD binding domain
PF00313 (7/7) 'Cold-shock' DNA-binding domain
PF00195 (7/7) Chalcone and stilbene synthases, N-terminal domain
PF00903 (6/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_17509 87.18 +- 3.01 3 0 0 0 0.03 +- 0.03 3 5

PF12704 (3/3) MacB-like periplasmic core domain
PF09130 (3/3) Domain of unknown function (DUF1932)
PF02687 (3/3) FtsX-like permease family
PF01471 (3/3) Putative peptidoglycan binding domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17508 67.53 +- 10.99 3 0 0 0 0.12 +- 0.12 3 7

PF18050 (3/3) Cyclophilin-like family
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_27272 320.94 +- 35.15 2 0 0 0 0.06 +- 0.05 2 9

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/2) Alpha galactosidase A
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF01120 (2/2) Alpha-L-fucosidase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_219 63.09 +- 78.25 28 0 2 0 0.08 +- 0.15 28 3

PF14019 (28/28) Protein of unknown function (DUF4235)
PF12277 (28/28) Protein of unknown function (DUF3618)
PF07332 (28/28) Putative Actinobacterial Holin-X, holin superfamily III
precursor_jaccard_groups_8779 344.79 +- 140.15 5 0 0 0 0.03 +- 0.04 5 20

PF17853 (5/5) GGDEF-like domain
PF16483 (5/5) Beta-1,3-glucanase
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12077 (5/5) Transmembrane protein of unknown function (DUF3556)
PF06314 (5/5) Acetoacetate decarboxylase (ADC)
PF03466 (5/5) LysR substrate binding domain
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02737 (5/5) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (5/5) CoA-transferase family III
PF00795 (5/5) Carbon-nitrogen hydrolase
PF00754 (5/5) F5/8 type C domain
PF00725 (5/5) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (5/5) Enoyl-CoA hydratase/isomerase
PF00324 (5/5) Amino acid permease
PF00126 (5/5) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_183 519.75 +- 960.32 19 0 19 19 0.05 +- 0.12 19 7

TIGR04363 (19/19) FxLD family lantipeptide
TIGR03891 (19/19) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (19/19) Lantibiotic biosynthesis dehydratase C-term
PF05147 (19/19) Lanthionine synthetase C-like protein
PF04738 (19/19) Lantibiotic dehydratase, N terminus
TIGR04364 (18/19) methyltransferase, FxLD system
PF01135 (18/19) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_jaccard_groups_29354 17.08 +- 2.28 2 0 0 0 0.12 +- 0.07 2 5

PF14361 (2/2) RsbT co-antagonist protein rsbRD N-terminal domain
PF12802 (2/2) MarR family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01740 (2/2) STAS domain
precursor_jaccard_groups_43893 810.28 +- 423.28 2 0 0 1 0.04 +- 0.15 2 15

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01478 (2/2) Type IV leader peptidase family
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
TIGR00702 (1/2) YcaO-type kinase domain
PF13649 (1/2) Methyltransferase domain
PF07812 (1/2) TfuA-like protein
PF07479 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01210 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
PF00482 (1/2) Type II secretion system (T2SS), protein F
precursor_jaccard_groups_38410 31.48 +- 1.93 2 0 0 0 0.13 +- 0.13 2 8

PF17128 (2/2) Domain of unknown function (DUF5107)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12840 (2/2) Helix-turn-helix domain
PF11706 (2/2) CGNR zinc finger
PF07336 (2/2) Putative stress-induced transcription regulator
PF05977 (2/2) Transmembrane secretion effector
PF13411 (1/2) MerR HTH family regulatory protein
PF07739 (1/2) TipAS antibiotic-recognition domain
precursor_jaccard_groups_17987 35.19 +- 12.64 3 0 0 0 0.19 +- 0.32 3 7

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (3/3) ABC transporter transmembrane region
PF00501 (3/3) AMP-binding enzyme
PF00248 (3/3) Aldo/keto reductase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17983 57.42 +- 1.60 2 0 0 0 0.17 +- 0.25 2 9

PF13671 (2/2) AAA domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_45040 146.17 +- 19.69 2 0 2 0 0.04 +- 0.02 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_692 30.92 +- 4.49 16 0 0 16 0.10 +- 0.10 16 3

PF02547 (16/16) Queuosine biosynthesis protein
PF00881 (16/16) Nitroreductase family
PF00106 (16/16) short chain dehydrogenase
precursor_jaccard_groups_45519 38.06 +- 0.32 2 0 0 0 0.11 +- 0.26 2 13

TIGR02170 (2/2) thymidylate synthase, flavin-dependent
TIGR00730 (2/2) TIGR00730 family protein
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03641 (2/2) Possible lysine decarboxylase
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02655 (2/2) ATP-grasp domain
PF02511 (2/2) Thymidylate synthase complementing protein
PF00860 (2/2) Permease family
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_29519 1750.00 +- 450.00 2 0 2 0 0.01 +- 0.00 2 13

TIGR02320 (2/2) phosphoenolpyruvate mutase
PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF04909 (2/2) Amidohydrolase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01566 (2/2) Natural resistance-associated macrophage protein
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00202 (2/2) Aminotransferase class-III
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_8473 205.39 +- 158.89 5 0 5 0 0.05 +- 0.04 5 13

PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/5) Acyl transferase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
TIGR04020 (4/5) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/5) amino acid adenylation domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF00668 (4/5) Condensation domain
PF00501 (4/5) AMP-binding enzyme
PF00296 (4/5) Luciferase-like monooxygenase
precursor_jaccard_groups_4065 222.48 +- 53.07 3 0 0 0 0.01 +- 0.01 3 3

PF04134 (3/3) Protein of unknown function, DUF393
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13560 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_27278 518.00 +- 2.00 2 0 2 0 0.01 +- 0.00 2 6

PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4066 24.89 +- 11.62 2 0 0 0 0.15 +- 0.17 2 5

TIGR03356 (2/2) beta-galactosidase
PF07690 (2/2) Major Facilitator Superfamily
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_40019 150.11 +- 37.53 2 0 0 0 0.06 +- 0.05 2 6

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00313 (2/2) 'Cold-shock' DNA-binding domain
precursor_jaccard_groups_18615 40.88 +- 28.11 3 0 0 0 0.14 +- 0.23 3 5

PF11127 (3/3) Protein of unknown function (DUF2892)
PF02583 (3/3) Metal-sensitive transcriptional repressor
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00581 (3/3) Rhodanese-like domain
precursor_jaccard_groups_28353 141.49 +- 102.26 2 0 0 0 0.13 +- 0.28 2 6

PF14742 (2/2) N-terminal domain of (some) glycogen debranching enzymes
PF11941 (2/2) Domain of unknown function (DUF3459)
PF06202 (2/2) Amylo-alpha-1,6-glucosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_28355 268.29 +- 123.61 2 0 0 0 0.06 +- 0.16 2 14

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00975 (2/2) phosphate ABC transporter, phosphate-binding protein PstS
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00972 (2/2) phosphate ABC transporter, ATP-binding protein
PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF16640 (2/2) Bacterial Ig-like domain (group 3)
PF12849 (2/2) PBP superfamily domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05908 (2/2) Poly-gamma-glutamate hydrolase
PF04203 (2/2) Sortase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00041 (2/2) Fibronectin type III domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_20340 58.97 +- 38.44 3 0 1 0 0.11 +- 0.24 3 14

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13607 (3/3) Succinyl-CoA ligase like flavodoxin domain
PF13549 (3/3) ATP-grasp domain
PF13459 (3/3) 4Fe-4S single cluster domain
PF13380 (3/3) CoA binding domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (3/3) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF10589 (2/3) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02834 (2/3) LigT like Phosphoesterase
precursor_jaccard_groups_1568 155.16 +- 85.36 14 0 14 0 0.03 +- 0.04 14 8

PF13649 (14/14) Methyltransferase domain
PF13450 (14/14) NAD(P)-binding Rossmann-like domain
PF12697 (14/14) Alpha/beta hydrolase family
PF00664 (14/14) ABC transporter transmembrane region
PF00005 (14/14) ABC transporter
PF07730 (13/14) Histidine kinase
PF00196 (7/14) Bacterial regulatory proteins, luxR family
PF00072 (7/14) Response regulator receiver domain
precursor_jaccard_groups_38305 540.00 +- 110.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
PF13649 (2/2) Methyltransferase domain
PF01380 (2/2) SIS domain
PF01263 (2/2) Aldose 1-epimerase
PF00550 (2/2) Phosphopantetheine attachment site
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_2707 8.16 +- 0.03 2 0 0 0 0.25 +- 0.39 2 4

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF18029 (2/2) Glyoxalase-like domain
PF09335 (2/2) SNARE associated Golgi protein
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_jaccard_groups_2704 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix
precursor_jaccard_groups_40277 39.31 +- 0.08 2 0 0 0 0.13 +- 0.22 2 9

PF10009 (2/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF02687 (2/2) FtsX-like permease family
PF01063 (2/2) Amino-transferase class IV
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
precursor_jaccard_groups_38856 257.12 +- 18.79 2 0 0 0 0.04 +- 0.06 2 8

PF05426 (2/2) Alginate lyase
PF05345 (2/2) Putative Ig domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00295 (2/2) Glycosyl hydrolases family 28
PF00135 (2/2) Carboxylesterase family
TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_24686 15.71 +- 0.54 2 0 1 0 0.13 +- 0.14 2 5

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00331 (2/2) Glycosyl hydrolase family 10
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_26417 561.39 +- 83.61 2 0 0 0 0.02 +- 0.03 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_17798 144.24 +- 21.37 3 0 0 0 0.02 +- 0.02 3 4

PF13560 (3/3) Helix-turn-helix domain
PF08241 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
precursor_jaccard_groups_24689 466.40 +- 53.60 2 0 0 0 0.01 +- 0.00 2 4

PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_3842 1732.53 +- 1215.24 10 0 1 10 0.02 +- 0.03 10 25

TIGR03812 (10/10) tyrosine decarboxylase MnfA
PF17755 (10/10) UvrA DNA-binding domain
PF16861 (10/10) Carbamoyltransferase C-terminus
PF16169 (10/10) Domain of unknown function (DUF4872)
PF14399 (10/10) Butirosin biosynthesis protein H, N-terminal
PF13370 (10/10) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (10/10) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (10/10) DNA alkylation repair enzyme
PF08241 (10/10) Methyltransferase domain
PF04879 (10/10) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (10/10) Radical SAM superfamily
PF03241 (10/10) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (10/10) Carbamoyltransferase N-terminus
PF02310 (10/10) B12 binding domain
PF02195 (10/10) ParB-like nuclease domain
PF01613 (10/10) Flavin reductase like domain
PF01568 (10/10) Molydopterin dinucleotide binding domain
PF01061 (10/10) ABC-2 type transporter
PF00805 (10/10) Pentapeptide repeats (8 copies)
PF00795 (10/10) Carbon-nitrogen hydrolase
PF00384 (10/10) Molybdopterin oxidoreductase
PF00291 (10/10) Pyridoxal-phosphate dependent enzyme
PF00282 (10/10) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (10/10) ABC transporter
PF00501 (9/10) AMP-binding enzyme
precursor_jaccard_groups_7590 318.92 +- 254.42 2 0 0 0 0.03 +- 0.04 2 6

TIGR03560 (2/2) probable F420-dependent oxidoreductase, Rv1855c family
PF05922 (2/2) Peptidase inhibitor I9
PF00296 (2/2) Luciferase-like monooxygenase
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
PF00501 (1/2) AMP-binding enzyme
precursor_jaccard_groups_43471 151.58 +- 28.42 2 0 0 0 0.02 +- 0.02 2 3

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_43473 36.10 +- 11.29 2 0 0 2 0.13 +- 0.14 2 12

TIGR03104 (2/2) asparagine synthase family amidotransferase
TIGR00377 (2/2) anti-anti-sigma factor
TIGR00229 (2/2) PAS domain S-box protein
PF13537 (2/2) Glutamine amidotransferase domain
PF13466 (2/2) STAS domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00733 (2/2) Asparagine synthase
PF00326 (2/2) Prolyl oligopeptidase family
TIGR02050 (1/2) carboxylate-amine ligase, YbdK family
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
precursor_jaccard_groups_3496 980.88 +- 903.75 5 0 4 0 0.04 +- 0.11 5 8

TIGR03558 (5/5) luciferase family oxidoreductase, group 1
PF13370 (5/5) 4Fe-4S single cluster domain of Ferredoxin I
PF08352 (5/5) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00496 (5/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (5/5) Luciferase-like monooxygenase
PF00067 (5/5) Cytochrome P450
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_4347 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
precursor_jaccard_groups_40306 552.65 +- 97.35 2 0 0 0 0.03 +- 0.05 2 11

TIGR03211 (2/2) catechol 2,3 dioxygenase
PF09084 (2/2) NMT1/THI5 like
PF07690 (2/2) Major Facilitator Superfamily
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26812 91.70 +- 34.15 2 0 0 0 0.16 +- 0.21 2 8

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_25539 1305.99 +- 644.01 2 0 2 0 0.02 +- 0.04 2 14

TIGR01733 (2/2) amino acid adenylation domain
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05175 (2/2) Methyltransferase small domain
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00117 (2/2) Glutamine amidotransferase class-I
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_23480 45.01 +- 6.31 2 0 2 0 0.14 +- 0.26 2 15

TIGR02416 (2/2) carbon-monoxide dehydrogenase, large subunit
TIGR00223 (2/2) aspartate 1-decarboxylase
PF14542 (2/2) GCN5-related N-acetyl-transferase
PF13478 (2/2) XdhC Rossmann domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF05762 (2/2) VWA domain containing CoxE-like protein
PF04945 (2/2) YHS domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF02261 (2/2) Aspartate decarboxylase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_23487 54.92 +- 12.70 2 0 0 0 0.08 +- 0.05 2 10

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF04828 (2/2) Glutathione-dependent formaldehyde-activating enzyme
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
precursor_jaccard_groups_7393 36.92 +- 14.90 5 0 0 0 0.06 +- 0.08 5 3

PF09586 (5/5) Bacterial membrane protein YfhO
PF04138 (5/5) GtrA-like protein
PF00535 (5/5) Glycosyl transferase family 2
precursor_jaccard_groups_31756 206.21 +- 94.79 2 0 0 2 0.02 +- 0.01 2 4

PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF04055 (2/2) Radical SAM superfamily
PF00303 (2/2) Thymidylate synthase
precursor_jaccard_groups_31021 232.92 +- 168.42 2 0 2 0 0.04 +- 0.05 2 7

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (2/2) CoA-transferase family III
PF01494 (2/2) FAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_42788 615.47 +- 545.53 2 0 2 0 0.07 +- 0.20 2 14

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF03621 (2/2) MbtH-like protein
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00697 (2/2) N-(5'phosphoribosyl)anthranilate (PRA) isomerase
PF00591 (2/2) Glycosyl transferase family, a/b domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
precursor_jaccard_groups_43308 195.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF13191 (2/2) AAA ATPase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_31042 59.36 +- 9.75 2 0 0 0 0.05 +- 0.04 2 14

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_31043 156.00 +- 104.00 2 0 0 0 0.02 +- 0.02 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_4280 70.47 +- 17.17 4 0 0 0 0.21 +- 0.15 4 9

TIGR03860 (4/4) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (4/4) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF08445 (4/4) FR47-like protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00497 (4/4) Bacterial extracellular solute-binding proteins, family 3
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF13410 (2/4) Glutathione S-transferase, C-terminal domain
precursor_jaccard_groups_4283 28.49 +- 8.65 2 0 0 0 0.15 +- 0.16 2 5

PF14310 (2/2) Fibronectin type III-like domain
PF13802 (2/2) Galactose mutarotase-like
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
precursor_jaccard_groups_2140 28.71 +- 3.54 2 0 0 0 0.07 +- 0.07 2 4

PF13454 (2/2) FAD-NAD(P)-binding
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
precursor_jaccard_groups_33885 132.91 +- 39.09 2 0 0 0 0.05 +- 0.09 2 7

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_2632 16.13 +- 1.85 7 0 0 0 0.19 +- 0.36 7 7

TIGR01412 (7/7) Tat-translocated enzyme
PF07987 (7/7) Domain of unkown function (DUF1775)
PF05425 (7/7) Copper resistance protein D
PF04314 (7/7) Copper chaperone PCu(A)C
PF04261 (7/7) Dyp-type peroxidase family
PF04234 (7/7) CopC domain
PF02630 (7/7) SCO1/SenC
precursor_jaccard_groups_39349 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_3728 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_jaccard_groups_43781 216.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 2

PF06013 (2/2) Proteins of 100 residues with WXG
PF02254 (2/2) TrkA-N domain
precursor_jaccard_groups_43786 123.37 +- 26.63 2 0 2 0 0.03 +- 0.02 2 5

PF12697 (2/2) Alpha/beta hydrolase family
PF11239 (2/2) Protein of unknown function (DUF3040)
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
precursor_jaccard_groups_10519 109.46 +- 5.44 5 0 0 0 0.12 +- 0.30 5 11

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (5/5) argininosuccinate lyase
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF03972 (5/5) MmgE/PrpD family
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01522 (5/5) Polysaccharide deacetylase
PF00596 (5/5) Class II Aldolase and Adducin N-terminal domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_31332 61.17 +- 3.83 2 0 0 0 0.03 +- 0.02 2 3

PF14031 (2/2) Putative serine dehydratase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01168 (2/2) Alanine racemase, N-terminal domain
precursor_jaccard_groups_33006 176.61 +- 38.39 2 0 2 0 0.02 +- 0.01 2 3

PF08241 (2/2) Methyltransferase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00348 (2/2) Polyprenyl synthetase
precursor_jaccard_groups_24468 439.24 +- 91.93 2 0 0 0 0.02 +- 0.01 2 9

PF16884 (2/2) N-terminal domain of oxidoreductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_31335 285.84 +- 53.64 2 0 0 0 0.03 +- 0.01 2 13

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13229 (2/2) Right handed beta helix region
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07745 (2/2) Glycosyl hydrolase family 53
PF07224 (2/2) Chlorophyllase
PF04616 (2/2) Glycosyl hydrolases family 43
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF02371 (1/2) Transposase IS116/IS110/IS902 family
PF01548 (1/2) Transposase
precursor_jaccard_groups_10637 130.88 +- 93.57 5 0 0 0 0.08 +- 0.16 5 6

TIGR01840 (5/5) esterase, PHB depolymerase family
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10605 (5/5) 3HB-oligomer hydrolase (3HBOH)
PF10503 (5/5) Esterase PHB depolymerase
PF07519 (5/5) Tannase and feruloyl esterase
PF00501 (5/5) AMP-binding enzyme
precursor_jaccard_groups_16869 534.44 +- 505.56 2 0 2 0 0.07 +- 0.22 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00206 (2/2) Lyase
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF18130 (1/2) ATP-grasp N-terminal domain
PF13549 (1/2) ATP-grasp domain
PF08544 (1/2) GHMP kinases C terminal
PF00668 (1/2) Condensation domain
precursor_jaccard_groups_23668 230.67 +- 116.00 2 0 0 0 0.02 +- 0.03 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_9372 296.34 +- 213.33 5 0 2 0 0.07 +- 0.22 5 26

TIGR02100 (5/5) glycogen debranching enzyme GlgX
TIGR01515 (5/5) 1,4-alpha-glucan branching enzyme
TIGR00377 (5/5) anti-anti-sigma factor
PF18085 (5/5) Maltokinase N-terminal cap domain
PF17124 (5/5) ThiJ/PfpI family-like
PF13614 (5/5) AAA domain
PF13581 (5/5) Histidine kinase-like ATPase domain
PF13546 (5/5) DDE superfamily endonuclease
PF13466 (5/5) STAS domain
PF13460 (5/5) NAD(P)H-binding
PF13380 (5/5) CoA binding domain
PF11896 (5/5) Domain of unknown function (DUF3416)
PF07690 (5/5) Major Facilitator Superfamily
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF07221 (5/5) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (5/5) EthD domain
PF02922 (5/5) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (5/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (5/5) DJ-1/PfpI family
PF01740 (5/5) STAS domain
PF00483 (5/5) Nucleotidyl transferase
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF00128 (5/5) Alpha amylase, catalytic domain
PF02806 (4/5) Alpha amylase, C-terminal all-beta domain
PF00132 (4/5) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_32135 372.32 +- 128.18 2 0 0 0 0.03 +- 0.03 2 9

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_43096 262.96 +- 124.04 2 0 2 0 0.04 +- 0.07 2 14

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF12680 (2/2) SnoaL-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF00975 (1/2) Thioesterase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_43097 810.16 +- 149.84 2 0 2 0 0.03 +- 0.02 2 17

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02441 (2/2) Flavoprotein
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7000 39.61 +- 24.92 6 0 6 0 0.10 +- 0.09 6 4

PF05199 (6/6) GMC oxidoreductase
PF00732 (6/6) GMC oxidoreductase
PF00294 (6/6) pfkB family carbohydrate kinase
PF00248 (6/6) Aldo/keto reductase family
precursor_jaccard_groups_38720 91.67 +- 8.10 2 0 0 0 0.10 +- 0.13 2 12

PF17754 (2/2) MftR C-terminal domain
PF14759 (2/2) Reductase C-terminal
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF13305 (2/2) Tetracyclin repressor-like, C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF11528 (2/2) Protein of unknown function (DUF3224)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_42259 250.33 +- 103.89 2 0 0 0 0.14 +- 0.13 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
PF00487 (1/2) Fatty acid desaturase
precursor_jaccard_groups_17156 44.75 +- 8.66 3 0 0 0 0.07 +- 0.04 3 6

PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_3036 355.34 +- 479.62 12 0 0 0 0.04 +- 0.10 12 6

PF13520 (12/12) Amino acid permease
PF01636 (12/12) Phosphotransferase enzyme family
PF00120 (12/12) Glutamine synthetase, catalytic domain
PF00005 (12/12) ABC transporter
PF13560 (9/12) Helix-turn-helix domain
PF00196 (8/12) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_36830 390.00 +- 130.00 2 0 2 0 0.02 +- 0.01 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00106 (2/2) short chain dehydrogenase
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF06249 (1/2) Ethanolamine utilisation protein EutQ
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (1/2) Flavin reductase like domain
PF01425 (1/2) Amidase
precursor_jaccard_groups_11771 26.70 +- 12.90 3 0 0 0 0.10 +- 0.12 3 5

PF01513 (3/3) ATP-NAD kinase
PF00188 (3/3) Cysteine-rich secretory protein family
PF00067 (3/3) Cytochrome P450
PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF13560 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_18405 58.50 +- 1.38 3 0 3 0 0.15 +- 0.34 3 9

PF17926 (3/3) Tetracyclin repressor-like, C-terminal domain
PF13822 (3/3) Acyl-CoA carboxylase epsilon subunit
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13411 (3/3) MerR HTH family regulatory protein
PF09278 (3/3) MerR, DNA binding
PF07690 (3/3) Major Facilitator Superfamily
PF01361 (3/3) Tautomerase enzyme
PF01039 (3/3) Carboxyl transferase domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_10186 286.75 +- 318.52 5 0 0 0 0.06 +- 0.12 5 10

TIGR04316 (5/5) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF01494 (5/5) FAD binding domain
PF01474 (5/5) Class-II DAHP synthetase family
PF00857 (5/5) Isochorismatase family
PF00797 (5/5) N-acetyltransferase
PF00425 (5/5) chorismate binding enzyme
PF00117 (5/5) Glutamine amidotransferase class-I
PF00106 (3/5) short chain dehydrogenase
precursor_jaccard_groups_25383 378.02 +- 316.59 2 0 0 0 0.09 +- 0.25 2 7

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00857 (2/2) Isochorismatase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00144 (2/2) Beta-lactamase
precursor_jaccard_groups_35908 62.70 +- 14.83 2 0 0 1 0.22 +- 0.33 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
PF00069 (2/2) Protein kinase domain
PF13360 (1/2) PQQ-like domain
precursor_jaccard_groups_32599 1002.86 +- 0.00 2 0 2 0 0.02 +- 0.01 2 11

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF03466 (2/2) LysR substrate binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00664 (2/2) ABC transporter transmembrane region
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35126 279.92 +- 107.08 2 0 2 0 0.05 +- 0.04 2 10

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9516 161.85 +- 22.71 5 0 5 5 0.05 +- 0.09 5 10

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00144 (5/5) Beta-lactamase
PF13472 (4/5) GDSL-like Lipase/Acylhydrolase family
PF06094 (4/5) Gamma-glutamyl cyclotransferase, AIG2-like
PF01113 (4/5) Dihydrodipicolinate reductase, N-terminus
PF00069 (4/5) Protein kinase domain
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
precursor_jaccard_groups_9517 13.49 +- 0.49 2 0 0 0 0.15 +- 0.12 2 7

PF13439 (2/2) Glycosyltransferase Family 4
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF06737 (2/2) Transglycosylase-like domain
PF01476 (2/2) LysM domain
PF00534 (2/2) Glycosyl transferases group 1
PF11720 (1/2) Peptidase inhibitor I78 family
precursor_jaccard_groups_29417 594.00 +- 121.00 2 0 0 0 0.02 +- 0.00 2 6

PF13458 (2/2) Periplasmic binding protein
PF12399 (2/2) Branched-chain amino acid ATP-binding cassette transporter
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01565 (2/2) FAD binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_18537 14.51 +- 0.25 3 0 0 0 0.14 +- 0.04 3 4

TIGR01810 (3/3) choline dehydrogenase
PF05199 (3/3) GMC oxidoreductase
PF02219 (3/3) Methylenetetrahydrofolate reductase
PF00732 (3/3) GMC oxidoreductase
precursor_jaccard_groups_42438 129.59 +- 16.48 2 0 0 0 0.17 +- 0.16 2 8

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_18247 362.20 +- 37.21 3 0 0 0 0.01 +- 0.00 3 6

PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02803 (3/3) Thiolase, C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF00108 (3/3) Thiolase, N-terminal domain
precursor_jaccard_groups_18533 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_6734 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
precursor_jaccard_groups_12920 278.10 +- 119.76 4 0 4 0 0.02 +- 0.01 4 3

PF06912 (4/4) Protein of unknown function (DUF1275)
PF03928 (4/4) Haem-degrading
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_jaccard_groups_7641 47.86 +- 30.14 2 0 0 0 0.10 +- 0.18 2 5

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF03606 (2/2) C4-dicarboxylate anaerobic carrier
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_42431 203.62 +- 86.63 2 0 0 0 0.02 +- 0.01 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF07853 (2/2) Protein of unknown function (DUF1648)
PF04264 (2/2) YceI-like domain
precursor_jaccard_groups_35637 17.27 +- 3.94 2 0 0 0 0.18 +- 0.16 2 6

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09286 (2/2) Pro-kumamolisin, activation domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF02540 (2/2) NAD synthase
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_2453 283.90 +- 336.53 15 0 0 0 0.09 +- 0.22 15 12

PF03706 (15/15) Lysylphosphatidylglycerol synthase TM region
PF03372 (15/15) Endonuclease/Exonuclease/phosphatase family
PF01370 (15/15) NAD dependent epimerase/dehydratase family
PF01040 (15/15) UbiA prenyltransferase family
PF00535 (15/15) Glycosyl transferase family 2
PF00248 (15/15) Aldo/keto reductase family
PF00202 (15/15) Aminotransferase class-III
PF00196 (15/15) Bacterial regulatory proteins, luxR family
PF11755 (9/15) Protein of unknown function (DUF3311)
PF00583 (9/15) Acetyltransferase (GNAT) family
PF00474 (9/15) Sodium:solute symporter family
PF03176 (8/15) MMPL family
precursor_jaccard_groups_7130 75.22 +- 56.18 5 0 5 0 0.06 +- 0.06 5 2

PF00156 (5/5) Phosphoribosyl transferase domain
PF00082 (5/5) Subtilase family
precursor_jaccard_groups_7647 2698.22 +- 1333.42 6 0 6 6 0.01 +- 0.01 6 9

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13560 (6/6) Helix-turn-helix domain
PF04149 (6/6) Domain of unknown function (DUF397)
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/6) Nitroreductase family
PF00196 (5/6) Bacterial regulatory proteins, luxR family
TIGR03891 (3/6) thiopeptide-type bacteriocin biosynthesis domain
precursor_jaccard_groups_11522 147.87 +- 24.54 4 0 0 0 0.03 +- 0.04 4 10

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (4/4) benzoate transporter
PF17920 (4/4) Tetracyclin repressor-like, C-terminal domain
PF13454 (4/4) FAD-NAD(P)-binding
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_1429 155.71 +- 90.45 10 0 4 0 0.17 +- 0.26 10 11

PF11975 (10/10) Family 4 glycosyl hydrolase C-terminal domain
PF08376 (10/10) Nitrate and nitrite sensing
PF07690 (10/10) Major Facilitator Superfamily
PF05331 (10/10) Protein of unknown function (DUF742)
PF03259 (10/10) Roadblock/LC7 domain
PF02518 (10/10) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02056 (10/10) Family 4 glycosyl hydrolase
PF01547 (10/10) Bacterial extracellular solute-binding protein
PF00528 (10/10) Binding-protein-dependent transport system inner membrane component
PF00294 (10/10) pfkB family carbohydrate kinase
PF03537 (8/10) Glycoside-hydrolase family GH114
precursor_jaccard_groups_27320 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_1420 282.56 +- 301.57 10 0 10 10 0.05 +- 0.11 10 9

TIGR03891 (10/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (10/10) Lantibiotic biosynthesis dehydratase C-term
PF07690 (10/10) Major Facilitator Superfamily
PF05147 (10/10) Lanthionine synthetase C-like protein
PF04738 (10/10) Lantibiotic dehydratase, N terminus
PF02873 (10/10) UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
PF01565 (10/10) FAD binding domain
PF02826 (7/10) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01070 (7/10) FMN-dependent dehydrogenase
precursor_jaccard_groups_8914 2283.33 +- 419.55 5 2 3 5 0.01 +- 0.00 3 6

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (5/5) Asparagine synthase
TIGR01188 (3/5) daunorubicin resistance ABC transporter, ATP-binding protein
PF01061 (3/5) ABC-2 type transporter
PF00005 (3/5) ABC transporter
precursor_jaccard_groups_2852 240.36 +- 39.78 11 0 11 11 0.01 +- 0.00 11 4

TIGR03891 (11/11) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (11/11) Lantibiotic biosynthesis dehydratase C-term
PF05147 (11/11) Lanthionine synthetase C-like protein
PF04738 (11/11) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_8356 76.82 +- 8.36 3 0 0 0 0.17 +- 0.31 3 15

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF12643 (3/3) MazG-like family
PF05331 (3/3) Protein of unknown function (DUF742)
PF04472 (3/3) Cell division protein SepF
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
TIGR03560 (2/3) probable F420-dependent oxidoreductase, Rv1855c family
PF08220 (2/3) DeoR-like helix-turn-helix domain
PF02574 (2/3) Homocysteine S-methyltransferase
PF00455 (2/3) DeoR C terminal sensor domain
PF00296 (2/3) Luciferase-like monooxygenase
precursor_jaccard_groups_2855 590.86 +- 450.54 13 0 0 0 0.05 +- 0.06 13 5

PF05426 (13/13) Alginate lyase
PF01547 (13/13) Bacterial extracellular solute-binding protein
PF00528 (13/13) Binding-protein-dependent transport system inner membrane component
PF00295 (13/13) Glycosyl hydrolases family 28
PF00135 (8/13) Carboxylesterase family
precursor_jaccard_groups_14989 13.12 +- 0.00 2 0 0 0 0.23 +- 0.24 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13304 (2/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_33269 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4468 764.63 +- 408.17 4 0 4 4 0.04 +- 0.17 4 8

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF13520 (4/4) Amino acid permease
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
precursor_jaccard_groups_12672 190.95 +- 31.53 4 0 4 0 0.08 +- 0.03 4 17

TIGR03494 (4/4) salicylate synthase
TIGR01761 (4/4) thiazolinyl imide reductase
TIGR01733 (4/4) amino acid adenylation domain
PF18563 (4/4) TubC N-terminal docking domain
PF13649 (4/4) Methyltransferase domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08242 (4/4) Methyltransferase domain
PF03435 (4/4) Saccharopine dehydrogenase NADP binding domain
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00425 (4/4) chorismate binding enzyme
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_19113 138.08 +- 52.89 3 0 3 0 0.10 +- 0.26 3 19

TIGR03026 (3/3) nucleotide sugar dehydrogenase
TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF07730 (3/3) Histidine kinase
PF07690 (3/3) Major Facilitator Superfamily
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF01266 (3/3) FAD dependent oxidoreductase
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00975 (3/3) Thioesterase domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF08990 (2/3) Erythronolide synthase docking
precursor_jaccard_groups_33060 43.34 +- 13.14 2 0 0 0 0.18 +- 0.34 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF02687 (2/2) FtsX-like permease family
PF01526 (2/2) Tn3 transposase DDE domain
PF01494 (2/2) FAD binding domain
PF00005 (2/2) ABC transporter
PF13700 (1/2) Domain of unknown function (DUF4158)
precursor_jaccard_groups_39744 134.33 +- 125.67 2 0 0 0 0.12 +- 0.25 2 4

TIGR04444 (2/2) chorismatase, FkbO/Hyg5 family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00892 (2/2) EamA-like transporter family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_27819 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_27768 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_9201 92.74 +- 70.19 5 0 0 0 0.08 +- 0.16 5 8

PF13244 (5/5) Domain of unknown function (DUF4040)
PF04039 (5/5) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (5/5) Na+/H+ antiporter subunit
PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (5/5) Proton-conducting membrane transporter
PF00106 (5/5) short chain dehydrogenase
PF04066 (4/5) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF01899 (4/5) Na+/H+ ion antiporter subunit
precursor_jaccard_groups_1885 66.42 +- 20.13 7 0 0 0 0.04 +- 0.04 7 3

PF18368 (7/7) Exo-beta-D-glucosaminidase Ig-fold domain
PF07166 (7/7) Protein of unknown function (DUF1398)
PF00703 (7/7) Glycosyl hydrolases family 2
precursor_jaccard_groups_19751 104.14 +- 47.99 3 0 0 0 0.11 +- 0.09 3 7

PF12746 (3/3) GNAT acetyltransferase
PF11975 (3/3) Family 4 glycosyl hydrolase C-terminal domain
PF02056 (3/3) Family 4 glycosyl hydrolase
PF01833 (3/3) IPT/TIG domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase
precursor_jaccard_groups_37073 181.59 +- 0.00 2 0 0 0 0.06 +- 0.08 2 10

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF13377 (2/2) Periplasmic binding protein-like domain
PF13205 (2/2) Bacterial Ig-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_6605 191.19 +- 28.66 7 0 7 0 0.02 +- 0.01 7 6

PF13378 (7/7) Enolase C-terminal domain-like
PF05336 (7/7) L-rhamnose mutarotase
PF04909 (7/7) Amidohydrolase
PF02746 (7/7) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (7/7) Bacterial extracellular solute-binding protein
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_6604 616.98 +- 577.75 4 0 0 0 0.09 +- 0.24 4 14

TIGR01122 (4/4) branched-chain amino acid aminotransferase
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF11583 (4/4) P-aminobenzoate N-oxygenase AurF
PF07690 (4/4) Major Facilitator Superfamily
PF04339 (4/4) Peptidogalycan biosysnthesis/recognition
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (4/4) Malate/L-lactate dehydrogenase
PF02222 (4/4) ATP-grasp domain
PF01063 (4/4) Amino-transferase class IV
PF01070 (3/4) FMN-dependent dehydrogenase
PF00069 (2/4) Protein kinase domain
precursor_jaccard_groups_45009 67.49 +- 26.86 2 0 0 0 0.21 +- 0.05 2 4

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_18331 28.09 +- 0.23 2 0 0 0 0.11 +- 0.12 2 6

PF13183 (2/2) 4Fe-4S dicluster domain
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01565 (2/2) FAD binding domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_18330 42.86 +- 0.47 2 0 0 0 0.07 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF07730 (2/2) Histidine kinase
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00144 (2/2) Beta-lactamase
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_37981 71.47 +- 16.87 2 0 0 0 0.13 +- 0.09 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
precursor_jaccard_groups_7817 56.16 +- 13.04 3 0 0 0 0.18 +- 0.34 3 9

PF13458 (3/3) Periplasmic binding protein
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF00501 (3/3) AMP-binding enzyme
PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF13676 (2/3) TIR domain
PF12399 (2/3) Branched-chain amino acid ATP-binding cassette transporter
PF00400 (2/3) WD domain, G-beta repeat
PF00248 (2/3) Aldo/keto reductase family
PF00005 (2/3) ABC transporter
precursor_jaccard_groups_1396 94.18 +- 46.75 17 0 14 0 0.11 +- 0.09 17 8

PF13377 (17/17) Periplasmic binding protein-like domain
PF08220 (17/17) DeoR-like helix-turn-helix domain
PF02826 (17/17) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01663 (17/17) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01547 (17/17) Bacterial extracellular solute-binding protein
PF00528 (17/17) Binding-protein-dependent transport system inner membrane component
TIGR01509 (16/17) HAD hydrolase, family IA, variant 3
PF13419 (16/17) Haloacid dehalogenase-like hydrolase
precursor_jaccard_groups_35839 91.20 +- 16.95 2 0 0 0 0.12 +- 0.11 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01638 (2/2) HxlR-like helix-turn-helix
PF01613 (2/2) Flavin reductase like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1399 15.06 +- 1.07 27 0 0 0 0.20 +- 0.33 27 5

PF14472 (27/27) Domain of unknown function (DUF4429)
PF09851 (27/27) Short C-terminal domain
PF08241 (27/27) Methyltransferase domain
PF00106 (27/27) short chain dehydrogenase
PF13231 (25/27) Dolichyl-phosphate-mannose-protein mannosyltransferase
precursor_jaccard_groups_27366 118.43 +- 0.00 2 0 0 0 0.07 +- 0.10 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_27367 440.60 +- 79.40 2 0 0 0 0.01 +- 0.01 2 10

PF16864 (2/2) Dimerisation domain
PF08962 (2/2) Domain of unknown function (DUF1876)
PF05423 (2/2) Mycobacterium membrane protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF16655 (1/2) PhoD-like phosphatase, N-terminal domain
PF09423 (1/2) PhoD-like phosphatase
precursor_jaccard_groups_11585 40.41 +- 20.99 4 0 0 0 0.11 +- 0.14 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF05893 (4/4) Acyl-CoA reductase (LuxC)
PF04443 (4/4) Acyl-protein synthetase, LuxE
PF00501 (4/4) AMP-binding enzyme
PF02469 (3/4) Fasciclin domain
precursor_jaccard_groups_20953 75.74 +- 2.18 3 0 0 0 0.20 +- 0.16 3 20

TIGR02454 (3/3) cobalt ECF transporter T component CbiQ
TIGR01166 (3/3) cobalt ABC transporter, ATP-binding protein
TIGR01165 (3/3) cobalt transport protein
TIGR00377 (3/3) anti-anti-sigma factor
TIGR00229 (3/3) PAS domain S-box protein
TIGR00123 (3/3) cobalamin biosynthesis protein CbiM
PF13466 (3/3) STAS domain
PF12697 (3/3) Alpha/beta hydrolase family
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF02553 (3/3) Cobalt transport protein component CbiN
PF02361 (3/3) Cobalt transport protein
PF01891 (3/3) Cobalt uptake substrate-specific transmembrane region
PF00664 (3/3) ABC transporter transmembrane region
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
PF18029 (2/3) Glyoxalase-like domain
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_9992 76.28 +- 56.48 3 0 0 0 0.12 +- 0.23 3 12

TIGR01792 (3/3) urease, alpha subunit
TIGR00193 (3/3) urease, gamma subunit
TIGR00192 (3/3) urease, beta subunit
TIGR00101 (3/3) urease accessory protein UreG
PF15531 (3/3) Bacterial toxin 27
PF02492 (3/3) CobW/HypB/UreG, nucleotide-binding domain
PF01979 (3/3) Amidohydrolase family
PF01774 (3/3) UreD urease accessory protein
PF01730 (3/3) UreF
PF00699 (3/3) Urease beta subunit
PF00547 (3/3) Urease, gamma subunit
PF00449 (3/3) Urease alpha-subunit, N-terminal domain
precursor_jaccard_groups_22449 215.00 +- 71.67 2 0 2 0 0.02 +- 0.02 2 6

TIGR03105 (2/2) glutamine synthetase, type III
PF13522 (2/2) Glutamine amidotransferase domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01493 (2/2) GXGXG motif
PF01266 (2/2) FAD dependent oxidoreductase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_jaccard_groups_33409 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_27103 143.00 +- 117.00 2 0 0 0 0.04 +- 0.07 2 3

PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_27105 34.70 +- 1.94 2 0 0 0 0.13 +- 0.14 2 8

PF07730 (2/2) Histidine kinase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00877 (2/2) NlpC/P60 family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF17829 (1/2) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (1/2) Glycosyl hydrolase family 115
precursor_jaccard_groups_19576 215.00 +- 60.81 3 0 3 0 0.01 +- 0.01 3 3

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_8136 314.51 +- 163.03 6 0 6 0 0.04 +- 0.02 6 9

PF16861 (6/6) Carbamoyltransferase C-terminus
PF13560 (6/6) Helix-turn-helix domain
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00668 (6/6) Condensation domain
PF00664 (6/6) ABC transporter transmembrane region
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_19572 158.18 +- 110.97 3 0 3 0 0.09 +- 0.14 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (3/3) Sigma-70, region 4
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04542 (3/3) Sigma-70 region 2
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_1371 270.33 +- 247.56 25 0 25 0 0.14 +- 0.28 25 20

PF13193 (25/25) AMP-binding enzyme C-terminal domain
PF12840 (25/25) Helix-turn-helix domain
PF03621 (25/25) MbtH-like protein
PF02668 (25/25) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (25/25) Condensation domain
PF00550 (25/25) Phosphopantetheine attachment site
PF00501 (25/25) AMP-binding enzyme
PF00196 (25/25) Bacterial regulatory proteins, luxR family
PF00144 (25/25) Beta-lactamase
PF00072 (25/25) Response regulator receiver domain
PF00005 (25/25) ABC transporter
TIGR04462 (24/25) enduracididine biosynthesis enzyme MppP
TIGR04460 (24/25) enduracididine biosynthesis enzyme MppR
TIGR01733 (24/25) amino acid adenylation domain
TIGR01720 (24/25) non-ribosomal peptide synthase domain TIGR01720
PF07730 (24/25) Histidine kinase
PF06314 (24/25) Acetoacetate decarboxylase (ADC)
PF05977 (24/25) Transmembrane secretion effector
PF00155 (24/25) Aminotransferase class I and II
PF12698 (18/25) ABC-2 family transporter protein
precursor_jaccard_groups_20971 14.88 +- 0.00 2 0 0 0 0.20 +- 0.05 2 6

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF03466 (2/2) LysR substrate binding domain
PF02803 (2/2) Thiolase, C-terminal domain
PF01575 (2/2) MaoC like domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00108 (2/2) Thiolase, N-terminal domain
precursor_jaccard_groups_1775 212.39 +- 119.81 11 1 10 0 0.03 +- 0.07 10 8

PF13649 (11/11) Methyltransferase domain
PF00664 (11/11) ABC transporter transmembrane region
PF00005 (11/11) ABC transporter
PF13450 (10/11) NAD(P)-binding Rossmann-like domain
PF12697 (10/11) Alpha/beta hydrolase family
PF12821 (8/11) Threonine/Serine exporter, ThrE
PF06738 (8/11) Putative threonine/serine exporter
PF13518 (7/11) Helix-turn-helix domain
precursor_jaccard_groups_33401 873.00 +- 288.00 2 0 0 0 0.01 +- 0.00 2 7

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13382 (2/2) Adenine deaminase C-terminal domain
PF08402 (2/2) TOBE domain
PF01979 (2/2) Amidohydrolase family
PF01156 (2/2) Inosine-uridine preferring nucleoside hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_20966 44.98 +- 10.31 2 0 2 0 0.04 +- 0.03 2 2

PF01522 (2/2) Polysaccharide deacetylase
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_31999 965.25 +- 464.75 2 0 0 0 0.01 +- 0.02 2 8

PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10369 73.52 +- 37.13 5 0 5 5 0.07 +- 0.06 5 5

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (5/5) Asparagine synthase
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_14857 98.56 +- 110.67 4 0 0 0 0.14 +- 0.30 4 8

PF13183 (4/4) 4Fe-4S dicluster domain
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01565 (4/4) FAD binding domain
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
precursor_jaccard_groups_26563 1216.73 +- 96.73 2 0 0 0 0.01 +- 0.01 2 9

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF03466 (2/2) LysR substrate binding domain
PF00884 (2/2) Sulfatase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_10363 48.88 +- 7.63 3 0 0 3 0.06 +- 0.06 3 3

PF10935 (3/3) Protein of unknown function (DUF2637)
PF07690 (3/3) Major Facilitator Superfamily
PF00881 (3/3) Nitroreductase family
precursor_jaccard_groups_480 372.51 +- 120.76 31 0 5 0 0.06 +- 0.17 31 14

TIGR01850 (31/31) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (31/31) RimK-like ATP-grasp domain
PF02779 (31/31) Transketolase, pyrimidine binding domain
PF01118 (31/31) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (31/31) Transketolase, thiamine diphosphate binding domain
TIGR01902 (30/31) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (30/31) Peptidase family M20/M25/M40
PF00696 (30/31) Amino acid kinase family
PF01041 (29/31) DegT/DnrJ/EryC1/StrS aminotransferase family
TIGR00768 (26/31) alpha-L-glutamate ligase, RimK family
PF18603 (25/31) L-amino acid ligase C-terminal domain 2
PF18130 (25/31) ATP-grasp N-terminal domain
PF13535 (25/31) ATP-grasp domain
PF07690 (25/31) Major Facilitator Superfamily
precursor_jaccard_groups_13984 71.17 +- 41.66 3 0 0 0 0.04 +- 0.05 3 2

PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01872 (3/3) RibD C-terminal domain
precursor_jaccard_groups_37361 65.49 +- 10.34 2 0 0 0 0.19 +- 0.20 2 5

PF14273 (2/2) Domain of unknown function (DUF4360)
PF14016 (2/2) Protein of unknown function (DUF4232)
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01925 (2/2) Sulfite exporter TauE/SafE
precursor_jaccard_groups_39832 171.32 +- 2.02 2 0 0 0 0.04 +- 0.02 2 11

TIGR00069 (2/2) histidinol dehydrogenase
PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF07366 (2/2) SnoaL-like polyketide cyclase
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00815 (2/2) Histidinol dehydrogenase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00106 (2/2) short chain dehydrogenase
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_8003 1561.57 +- 1191.59 6 0 1 0 0.02 +- 0.01 6 13

TIGR01263 (6/6) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF14696 (6/6) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (6/6) ATP-grasp domain
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (6/6) Prephenate dehydrogenase
PF01613 (6/6) Flavin reductase like domain
PF01070 (6/6) FMN-dependent dehydrogenase
PF00903 (6/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (6/6) Luciferase-like monooxygenase
PF00155 (6/6) Aminotransferase class I and II
PF18130 (5/6) ATP-grasp N-terminal domain
PF00106 (3/6) short chain dehydrogenase
precursor_jaccard_groups_33317 344.00 +- 172.00 2 0 0 0 0.02 +- 0.02 2 2

PF03972 (2/2) MmgE/PrpD family
PF00857 (2/2) Isochorismatase family
precursor_jaccard_groups_12454 486.41 +- 428.32 2 0 0 0 0.08 +- 0.22 2 16

TIGR01766 (2/2) transposase, IS605 OrfB family
PF13581 (2/2) Histidine kinase-like ATPase domain
PF12730 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF02698 (2/2) DUF218 domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF05630 (1/2) Necrosis inducing protein (NPP1)
PF02057 (1/2) Glycosyl hydrolase family 59
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
precursor_jaccard_groups_26215 140.66 +- 30.94 2 0 0 0 0.11 +- 0.11 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12802 (2/2) MarR family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04072 (2/2) Leucine carboxyl methyltransferase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26740 81.58 +- 1.73 2 0 0 0 0.17 +- 0.18 2 16

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13847 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_27615 411.41 +- 362.59 2 0 0 0 0.07 +- 0.17 2 11

TIGR00673 (2/2) cyanase
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF09587 (2/2) Bacterial capsule synthesis protein PGA_cap
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02560 (2/2) Cyanate lyase C-terminal domain
PF01565 (2/2) FAD binding domain
PF00899 (2/2) ThiF family
PF00206 (2/2) Lyase
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_jaccard_groups_16172 61.94 +- 1.47 2 0 0 2 0.06 +- 0.10 2 4

PF13649 (2/2) Methyltransferase domain
PF01183 (2/2) Glycosyl hydrolases family 25
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00881 (2/2) Nitroreductase family
precursor_jaccard_groups_32242 72.50 +- 12.83 2 0 0 0 0.17 +- 0.30 2 13

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00630 (2/2) excinuclease ABC subunit A
PF17760 (2/2) UvrA interaction domain
PF17755 (2/2) UvrA DNA-binding domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13280 (2/2) WYL domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF00140 (2/2) Sigma-70 factor, region 1.2
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1171 55.51 +- 24.58 3 0 0 0 0.04 +- 0.04 3 2

PF13649 (3/3) Methyltransferase domain
PF03009 (3/3) Glycerophosphoryl diester phosphodiesterase family
precursor_jaccard_groups_19371 46.35 +- 21.55 3 0 0 0 0.13 +- 0.16 3 3

PF05425 (3/3) Copper resistance protein D
PF02515 (3/3) CoA-transferase family III
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_12584 363.20 +- 37.90 3 0 0 3 0.01 +- 0.00 3 5

TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF13537 (3/3) Glutamine amidotransferase domain
PF01474 (3/3) Class-II DAHP synthetase family
PF00733 (3/3) Asparagine synthase
PF00221 (3/3) Aromatic amino acid lyase
precursor_jaccard_groups_5207 964.27 +- 325.73 2 0 0 0 0.01 +- 0.02 2 12

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_31995 12.29 +- 3.01 2 0 0 0 0.17 +- 0.11 2 6

PF14542 (2/2) GCN5-related N-acetyl-transferase
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_2023 29.64 +- 5.15 4 0 1 0 0.17 +- 0.19 4 11

PF13478 (4/4) XdhC Rossmann domain
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF06240 (4/4) Carbon monoxide dehydrogenase subunit G (CoxG)
PF05762 (4/4) VWA domain containing CoxE-like protein
PF03450 (4/4) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (4/4) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (4/4) XdhC and CoxI family
PF01799 (4/4) [2Fe-2S] binding domain
PF01315 (4/4) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (4/4) FAD binding domain in molybdopterin dehydrogenase
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_21627 152.60 +- 103.30 3 0 2 3 0.05 +- 0.05 3 16

TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
TIGR00128 (3/3) malonyl CoA-acyl carrier protein transacylase
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13537 (3/3) Glutamine amidotransferase domain
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00733 (3/3) Asparagine synthase
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
TIGR00421 (2/3) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/3) decarboxylase, UbiD family
PF08242 (2/3) Methyltransferase domain
PF02441 (2/3) Flavoprotein
PF01977 (2/3) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
precursor_jaccard_groups_2022 36.98 +- 6.02 2 0 0 0 0.07 +- 0.04 2 6

PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07730 (2/2) Histidine kinase
PF00890 (2/2) FAD binding domain
PF00083 (2/2) Sugar (and other) transporter
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_32852 114.99 +- 57.07 2 0 0 0 0.13 +- 0.07 2 5

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF02254 (2/2) TrkA-N domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_28905 824.48 +- 723.52 2 0 0 2 0.06 +- 0.23 2 8

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01979 (2/2) Amidohydrolase family
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_15918 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF06737 (2/2) Transglycosylase-like domain
PF05257 (2/2) CHAP domain
precursor_jaccard_groups_354 12.34 +- 0.24 2 0 0 0 0.21 +- 0.23 2 4

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF13439 (2/2) Glycosyltransferase Family 4
PF00534 (2/2) Glycosyl transferases group 1
PF01494 (1/2) FAD binding domain
precursor_jaccard_groups_42911 82.79 +- 2.04 2 0 2 0 0.08 +- 0.02 2 13

PF17645 (2/2) Arylmalonate decarboxylase
PF12697 (2/2) Alpha/beta hydrolase family
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01494 (2/2) FAD binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (2/2) MarR family
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00857 (2/2) Isochorismatase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_25980 46.67 +- 0.00 2 0 1 0 0.09 +- 0.11 2 5

PF12146 (2/2) Serine aminopeptidase, S33
PF11338 (2/2) Protein of unknown function (DUF3140)
PF04909 (2/2) Amidohydrolase
PF04672 (2/2) S-adenosyl methyltransferase
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_25329 335.57 +- 179.23 2 0 0 0 0.06 +- 0.12 2 14

PF13378 (2/2) Enolase C-terminal domain-like
PF13229 (2/2) Right handed beta helix region
PF05336 (2/2) L-rhamnose mutarotase
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02368 (2/2) Bacterial Ig-like domain (group 2)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00248 (2/2) Aldo/keto reductase family
PF13551 (1/2) Winged helix-turn helix
PF12708 (1/2) Pectate lyase superfamily protein
PF07729 (1/2) FCD domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00295 (1/2) Glycosyl hydrolases family 28
precursor_jaccard_groups_358 295.49 +- 454.39 26 0 26 0 0.13 +- 0.26 26 14

PF03621 (26/26) MbtH-like protein
PF00501 (26/26) AMP-binding enzyme
TIGR01733 (25/26) amino acid adenylation domain
PF13193 (25/26) AMP-binding enzyme C-terminal domain
PF00550 (25/26) Phosphopantetheine attachment site
PF00975 (23/26) Thioesterase domain
PF00668 (23/26) Condensation domain
PF07690 (19/26) Major Facilitator Superfamily
PF02668 (16/26) Taurine catabolism dioxygenase TauD, TfdA family
TIGR01263 (14/26) 4-hydroxyphenylpyruvate dioxygenase
PF01070 (14/26) FMN-dependent dehydrogenase
PF00903 (14/26) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00155 (14/26) Aminotransferase class I and II
PF14696 (13/26) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
precursor_jaccard_groups_14156 81.71 +- 21.70 3 0 0 0 0.08 +- 0.19 3 13

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13607 (3/3) Succinyl-CoA ligase like flavodoxin domain
PF13549 (3/3) ATP-grasp domain
PF13459 (3/3) 4Fe-4S single cluster domain
PF13380 (3/3) CoA binding domain
PF10589 (3/3) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (3/3) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_29746 25.17 +- 3.50 2 0 0 0 0.12 +- 0.10 2 6

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF03606 (2/2) C4-dicarboxylate anaerobic carrier
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_8640 195.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01435 (2/2) Peptidase family M48
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_29180 184.36 +- 28.36 2 0 0 0 0.02 +- 0.01 2 5

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF12802 (2/2) MarR family
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_8644 211.31 +- 42.70 3 0 0 0 0.01 +- 0.01 3 6

PF17963 (3/3) Bacterial Ig domain
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF09992 (3/3) Phosphodiester glycosidase
PF04464 (3/3) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF01066 (3/3) CDP-alcohol phosphatidyltransferase
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_35360 25.24 +- 0.00 2 0 0 0 0.16 +- 0.10 2 5

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
PF13378 (2/2) Enolase C-terminal domain-like
PF02447 (2/2) GntP family permease
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_37568 16.45 +- 2.12 2 0 0 0 0.12 +- 0.23 2 5

PF13228 (2/2) Domain of unknown function (DUF4037)
PF08713 (2/2) DNA alkylation repair enzyme
PF07528 (2/2) DZF domain
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_5419 25.46 +- 11.40 7 0 0 0 0.15 +- 0.24 7 7

TIGR03696 (7/7) RHS repeat-associated core domain
TIGR01643 (7/7) YD repeat (two copies)
PF13641 (7/7) Glycosyltransferase like family 2
PF05593 (7/7) RHS Repeat
PF01757 (7/7) Acyltransferase family
PF01522 (7/7) Polysaccharide deacetylase
PF15657 (6/7) HNH/Endo VII superfamily nuclease toxins
precursor_jaccard_groups_33804 18.08 +- 0.35 2 0 2 2 0.17 +- 0.33 2 6

PF17885 (2/2) Styrene monooxygenase A putative substrate binding domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00494 (2/2) Squalene/phytoene synthase
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_3550 30.50 +- 12.49 3 0 0 0 0.13 +- 0.16 3 5

PF17932 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14472 (3/3) Domain of unknown function (DUF4429)
PF09851 (3/3) Short C-terminal domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_4271 27.16 +- 9.53 3 0 0 0 0.08 +- 0.05 3 4

TIGR01810 (3/3) choline dehydrogenase
PF05199 (3/3) GMC oxidoreductase
PF02219 (3/3) Methylenetetrahydrofolate reductase
PF00732 (3/3) GMC oxidoreductase
precursor_jaccard_groups_733 110.04 +- 74.90 9 0 9 9 0.03 +- 0.03 9 3

PF13575 (9/9) Domain of unknown function (DUF4135)
PF05147 (9/9) Lanthionine synthetase C-like protein
PF00106 (5/9) short chain dehydrogenase
precursor_jaccard_groups_25434 50.16 +- 18.59 2 0 0 0 0.16 +- 0.20 2 6

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_25436 195.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_3559 28.46 +- 0.00 2 0 0 0 0.21 +- 0.18 2 5

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02687 (2/2) FtsX-like permease family
PF01152 (2/2) Bacterial-like globin
PF00082 (2/2) Subtilase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10982 68.33 +- 9.05 4 0 0 0 0.04 +- 0.04 4 3

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF07690 (4/4) Major Facilitator Superfamily
PF00069 (4/4) Protein kinase domain
precursor_jaccard_groups_17538 154.57 +- 48.14 2 0 2 0 0.08 +- 0.18 2 15

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF03621 (2/2) MbtH-like protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_485 89.58 +- 36.83 6 0 0 0 0.17 +- 0.28 6 11

TIGR01777 (6/6) TIGR01777 family protein
TIGR01727 (6/6) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (6/6) N-terminal TM domain of oligopeptide transport permease C
PF08352 (6/6) Oligopeptide/dipeptide transporter, C-terminal region
PF08338 (6/6) Domain of unknown function (DUF1731)
PF01370 (6/6) NAD dependent epimerase/dehydratase family
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00496 (6/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00293 (6/6) NUDIX domain
PF00005 (6/6) ABC transporter
PF13671 (5/6) AAA domain
precursor_jaccard_groups_177 63.68 +- 48.69 16 0 6 16 0.07 +- 0.12 16 2

PF04055 (16/16) Radical SAM superfamily
PF00583 (16/16) Acetyltransferase (GNAT) family
precursor_jaccard_groups_21805 327.62 +- 23.17 3 0 0 0 0.01 +- 0.00 3 5

PF10014 (3/3) 2OG-Fe dioxygenase
PF07690 (3/3) Major Facilitator Superfamily
PF07366 (3/3) SnoaL-like polyketide cyclase
PF05223 (3/3) NTF2-like N-terminal transpeptidase domain
PF00905 (3/3) Penicillin binding protein transpeptidase domain
precursor_jaccard_groups_29296 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_29569 140.75 +- 119.25 2 0 0 0 0.05 +- 0.06 2 3

PF02018 (2/2) Carbohydrate binding domain
PF01872 (2/2) RibD C-terminal domain
PF00041 (2/2) Fibronectin type III domain
precursor_jaccard_groups_24453 35.12 +- 3.90 2 0 0 0 0.20 +- 0.33 2 13

TIGR02133 (2/2) ribose 5-phosphate isomerase
TIGR00232 (2/2) transketolase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00121 (2/2) Triosephosphate isomerase
precursor_jaccard_groups_8407 59.68 +- 25.10 6 0 1 0 0.16 +- 0.06 6 9

PF14310 (6/6) Fibronectin type III-like domain
PF13377 (6/6) Periplasmic binding protein-like domain
PF11625 (6/6) Protein of unknown function (DUF3253)
PF01915 (6/6) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00933 (6/6) Glycosyl hydrolase family 3 N terminal domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00150 (6/6) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_4070 1102.46 +- 294.80 8 0 8 0 0.01 +- 0.00 8 8

TIGR01733 (8/8) amino acid adenylation domain
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF00975 (8/8) Thioesterase domain
PF00668 (8/8) Condensation domain
PF00561 (8/8) alpha/beta hydrolase fold
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00326 (8/8) Prolyl oligopeptidase family
precursor_jaccard_groups_40064 139.87 +- 7.56 2 0 0 0 0.04 +- 0.06 2 7

TIGR04364 (2/2) methyltransferase, FxLD system
PF08242 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_37412 259.00 +- 1.00 2 0 2 2 0.01 +- 0.00 2 4

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_2734 151.03 +- 38.89 5 0 3 0 0.10 +- 0.22 5 18

PF13581 (5/5) Histidine kinase-like ATPase domain
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00561 (5/5) alpha/beta hydrolase fold
PF00501 (5/5) AMP-binding enzyme
PF00474 (5/5) Sodium:solute symporter family
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (5/5) Aminotransferase class-III
PF00171 (5/5) Aldehyde dehydrogenase family
PF00107 (5/5) Zinc-binding dehydrogenase
PF13450 (4/5) NAD(P)-binding Rossmann-like domain
PF01590 (4/5) GAF domain
precursor_jaccard_groups_20577 51.16 +- 8.06 3 0 3 0 0.17 +- 0.37 3 16

TIGR01490 (3/3) HAD hydrolase, family IB
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF12680 (3/3) SnoaL-like domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF03756 (3/3) A-factor biosynthesis hotdog domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01494 (3/3) FAD binding domain
PF01144 (3/3) Coenzyme A transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_25506 944.76 +- 201.90 2 0 0 0 0.01 +- 0.01 2 14

PF18565 (2/2) Glycoside hydrolase family 2 C-terminal domain 5
PF14498 (2/2) Glycosyl hydrolase family 65, N-terminal domain
PF14310 (2/2) Fibronectin type III-like domain
PF13546 (2/2) DDE superfamily endonuclease
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_641 106.33 +- 42.78 4 0 0 0 0.04 +- 0.04 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF00027 (4/4) Cyclic nucleotide-binding domain
PF13581 (2/4) Histidine kinase-like ATPase domain
PF08448 (2/4) PAS fold
PF01590 (2/4) GAF domain
precursor_jaccard_groups_643 85.12 +- 61.15 48 0 0 0 0.07 +- 0.05 48 4

PF13738 (48/48) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (48/48) FMN-dependent dehydrogenase
PF00999 (48/48) Sodium/hydrogen exchanger family
PF00067 (48/48) Cytochrome P450
precursor_jaccard_groups_11745 41.34 +- 27.70 4 0 0 0 0.08 +- 0.13 4 7

PF13424 (4/4) Tetratricopeptide repeat
PF07719 (4/4) Tetratricopeptide repeat
PF07504 (4/4) Fungalysin/Thermolysin Propeptide Motif
PF03413 (4/4) Peptidase propeptide and YPEB domain
PF02868 (4/4) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (4/4) Thermolysin metallopeptidase, catalytic domain
PF00348 (4/4) Polyprenyl synthetase
precursor_jaccard_groups_28163 88.74 +- 14.46 2 0 0 0 0.02 +- 0.02 2 2

PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_430 55.14 +- 24.67 19 0 0 0 0.14 +- 0.06 19 10

PF13370 (19/19) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (19/19) Pyridine nucleotide-disulphide oxidoreductase
PF06314 (19/19) Acetoacetate decarboxylase (ADC)
PF02900 (19/19) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01557 (19/19) Fumarylacetoacetate (FAA) hydrolase family
PF00171 (19/19) Aldehyde dehydrogenase family
PF14759 (18/19) Reductase C-terminal
PF17940 (14/19) Tetracyclin repressor-like, C-terminal domain
PF00440 (14/19) Bacterial regulatory proteins, tetR family
PF07722 (11/19) Peptidase C26
precursor_jaccard_groups_28164 102.22 +- 0.00 2 0 2 2 0.15 +- 0.26 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12704 (2/2) MacB-like periplasmic core domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_40205 208.94 +- 79.94 2 0 2 0 0.02 +- 0.04 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF14518 (2/2) Iron-containing redox enzyme
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF04820 (2/2) Tryptophan halogenase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_20374 136.62 +- 123.38 2 0 0 0 0.08 +- 0.12 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF09350 (2/2) Domain of unknown function (DUF1992)
precursor_jaccard_groups_40666 51.76 +- 6.54 2 0 0 0 0.16 +- 0.22 2 21

TIGR02635 (2/2) L-rhamnose isomerase
TIGR02632 (2/2) rhamnulose-1-phosphate aldolase/alcohol dehydrogenase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03777 (2/2) ChpA-C
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00202 (2/2) Aminotransferase class-III
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
TIGR00879 (1/2) MFS transporter, sugar porter (SP) family
PF12697 (1/2) Alpha/beta hydrolase family
PF06134 (1/2) L-rhamnose isomerase (RhaA)
PF03479 (1/2) Plants and Prokaryotes Conserved (PCC) domain
PF00210 (1/2) Ferritin-like domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00083 (1/2) Sugar (and other) transporter
precursor_jaccard_groups_40667 212.25 +- 174.75 2 0 0 0 0.05 +- 0.08 2 9

TIGR01995 (2/2) PTS system, beta-glucoside-specific IIABC component
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00232 (2/2) Glycosyl hydrolase family 1
PF13751 (1/2) Transposase DDE domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
precursor_jaccard_groups_44491 77.79 +- 20.60 2 0 0 0 0.14 +- 0.11 2 9

PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_1604 634.07 +- 722.81 11 2 9 11 0.02 +- 0.02 9 3

PF05402 (11/11) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (11/11) Asparagine synthase
PF13471 (10/11) Transglutaminase-like superfamily
precursor_jaccard_groups_24906 62.86 +- 0.00 2 0 2 0 0.19 +- 0.28 2 8

TIGR03571 (2/2) luciferase-type oxidoreductase, BA3436 family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (2/2) SnoaL-like domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF03928 (2/2) Haem-degrading
PF00857 (2/2) Isochorismatase family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_44499 22.54 +- 1.10 2 0 2 0 0.18 +- 0.24 2 5

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02525 (2/2) Flavodoxin-like fold
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_34265 118.75 +- 11.25 2 0 0 0 0.08 +- 0.11 2 7

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_43462 38.27 +- 1.42 2 0 0 0 0.05 +- 0.04 2 2

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_3153 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family
precursor_jaccard_groups_45631 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
precursor_jaccard_groups_38590 74.39 +- 33.94 2 0 2 0 0.17 +- 0.31 2 11

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF03551 (2/2) Transcriptional regulator PadR-like family
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_37890 92.86 +- 0.00 2 0 0 2 0.03 +- 0.02 2 6

TIGR04188 (2/2) methyltransferase, ATP-grasp peptide maturase system
TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
PF14408 (2/2) Ribosomally synthesised peptide in actinomycetes
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
precursor_jaccard_groups_43315 1498.58 +- 93.92 2 0 2 0 0.01 +- 0.00 2 16

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03795 (2/2) YCII-related domain
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01738 (2/2) Dienelactone hydrolase family
PF00890 (2/2) FAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_43317 93.40 +- 12.15 2 0 0 0 0.03 +- 0.05 2 6

TIGR03510 (2/2) XapX domain
PF12802 (2/2) MarR family
PF07883 (2/2) Cupin domain
PF07859 (2/2) alpha/beta hydrolase fold
PF07235 (2/2) Protein of unknown function (DUF1427)
PF04909 (2/2) Amidohydrolase
precursor_jaccard_groups_17818 37.07 +- 4.24 3 0 0 0 0.05 +- 0.02 3 1

PF03771 (3/3) Domain of unknown function (DUF317)
precursor_jaccard_groups_34043 595.22 +- 87.28 2 0 0 0 0.03 +- 0.03 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_43310 130.00 +- 0.00 2 0 2 0 0.02 +- 0.00 2 3

PF16864 (2/2) Dimerisation domain
PF00891 (2/2) O-methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_24589 160.09 +- 88.59 2 0 0 0 0.14 +- 0.12 2 19

PF16353 (2/2) Domain of unknown function(DUF4981)
PF06182 (2/2) ABC-2 family transporter protein
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (2/2) FAD binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00005 (2/2) ABC transporter
PF14587 (1/2) O-Glycosyl hydrolase family 30
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13412 (1/2) Winged helix-turn-helix DNA-binding
PF13377 (1/2) Periplasmic binding protein-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_24586 36.01 +- 0.55 2 0 0 0 0.08 +- 0.05 2 4

PF05336 (2/2) L-rhamnose mutarotase
PF02983 (2/2) Alpha-lytic protease prodomain
PF00754 (2/2) F5/8 type C domain
PF00722 (2/2) Glycosyl hydrolases family 16
precursor_jaccard_groups_28010 25.37 +- 8.92 2 0 1 0 0.13 +- 0.26 2 9

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF13377 (2/2) Periplasmic binding protein-like domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04314 (2/2) Copper chaperone PCu(A)C
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00155 (2/2) Aminotransferase class I and II
PF00122 (2/2) E1-E2 ATPase
precursor_jaccard_groups_31109 128.17 +- 24.49 2 0 2 2 0.13 +- 0.29 2 19

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13424 (2/2) Tetratricopeptide repeat
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08007 (2/2) Cupin superfamily protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00931 (2/2) NB-ARC domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_44142 298.86 +- 7.02 2 0 0 0 0.03 +- 0.01 2 15

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02353 (2/2) Mycolic acid cyclopropane synthetase
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_7255 67.92 +- 14.39 2 0 0 0 0.18 +- 0.35 2 9

TIGR03819 (2/2) helicase/secretion neighborhood ATPase
TIGR03815 (2/2) helicase/secretion neighborhood CpaE-like protein
PF14029 (2/2) Protein of unknown function (DUF4244)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03816 (1/2) helicase/secretion neighborhood TadE-like protein
PF07811 (1/2) TadE-like protein
precursor_jaccard_groups_23873 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 5

PF12261 (2/2) Thermostable hemolysin
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_jaccard_groups_7258 178.69 +- 94.17 6 0 0 0 0.02 +- 0.01 6 4

PF13377 (6/6) Periplasmic binding protein-like domain
PF01380 (6/6) SIS domain
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_jaccard_groups_34467 30.77 +- 0.22 2 0 0 0 0.19 +- 0.36 2 6

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01494 (2/2) FAD binding domain
precursor_jaccard_groups_1113 234.67 +- 88.75 31 0 0 0 0.05 +- 0.05 31 6

TIGR03930 (31/31) WXG100 family type VII secretion target
TIGR03921 (31/31) type VII secretion-associated serine protease mycosin
TIGR03919 (31/31) type VII secretion protein EccB
PF06013 (31/31) Proteins of 100 residues with WXG
PF05108 (31/31) Type VII secretion system ESX-1, transport TM domain B
PF00082 (31/31) Subtilase family
precursor_jaccard_groups_10562 1206.79 +- 1250.85 5 0 1 0 0.02 +- 0.03 5 13

PF17189 (5/5) Glycosyl hydrolase family 30 beta sandwich domain
PF14310 (5/5) Fibronectin type III-like domain
PF13416 (5/5) Bacterial extracellular solute-binding protein
PF13377 (5/5) Periplasmic binding protein-like domain
PF08244 (5/5) Glycosyl hydrolases family 32 C terminal
PF02055 (5/5) Glycosyl hydrolase family 30 TIM-barrel domain
PF01915 (5/5) Glycosyl hydrolase family 3 C-terminal domain
PF01833 (5/5) IPT/TIG domain
PF00933 (5/5) Glycosyl hydrolase family 3 N terminal domain
PF00754 (5/5) F5/8 type C domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00251 (5/5) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_2602 19.97 +- 17.12 7 0 0 0 0.19 +- 0.34 7 6

PF12161 (7/7) HsdM N-terminal domain
PF08463 (7/7) EcoEI R protein C-terminal
PF04851 (7/7) Type III restriction enzyme, res subunit
PF04313 (7/7) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (7/7) N-6 DNA Methylase
PF01420 (7/7) Type I restriction modification DNA specificity domain
precursor_jaccard_groups_33897 37.25 +- 3.10 2 0 2 0 0.08 +- 0.01 2 3

PF00550 (2/2) Phosphopantetheine attachment site
PF00268 (2/2) Ribonucleotide reductase, small chain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_386 75.64 +- 53.48 9 0 1 0 0.05 +- 0.03 9 2

PF07702 (9/9) UTRA domain
PF13673 (8/9) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_43791 112.97 +- 0.00 2 0 2 0 0.19 +- 0.32 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16864 (2/2) Dimerisation domain
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_45299 17.37 +- 1.74 2 0 0 0 0.12 +- 0.08 2 2

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF04616 (2/2) Glycosyl hydrolases family 43
precursor_jaccard_groups_39331 144.15 +- 36.04 2 0 0 0 0.06 +- 0.04 2 9

PF13671 (2/2) AAA domain
PF13649 (2/2) Methyltransferase domain
PF09364 (2/2) XFP N-terminal domain
PF09363 (2/2) XFP C-terminal domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (2/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF01427 (2/2) D-ala-D-ala dipeptidase
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_380 116.97 +- 106.29 25 0 24 24 0.11 +- 0.23 25 5

TIGR03975 (25/25) ribosomal peptide maturation radical SAM protein 1
PF07690 (25/25) Major Facilitator Superfamily
PF02310 (25/25) B12 binding domain
PF00326 (25/25) Prolyl oligopeptidase family
PF04055 (24/25) Radical SAM superfamily
precursor_jaccard_groups_3933 113.62 +- 60.94 3 0 0 0 0.04 +- 0.02 3 4

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF01613 (3/3) Flavin reductase like domain
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_23611 56.49 +- 37.65 2 0 0 0 0.08 +- 0.11 2 5

PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08357 (2/2) SEFIR domain
PF00348 (2/2) Polyprenyl synthetase
PF13676 (1/2) TIR domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
precursor_jaccard_groups_12986 291.68 +- 50.47 4 0 3 0 0.04 +- 0.08 4 6

PF13302 (4/4) Acetyltransferase (GNAT) domain
PF07690 (4/4) Major Facilitator Superfamily
PF06241 (4/4) Castor and Pollux, part of voltage-gated ion channel
PF05014 (4/4) Nucleoside 2-deoxyribosyltransferase
PF02633 (4/4) Creatinine amidohydrolase
PF01180 (4/4) Dihydroorotate dehydrogenase
precursor_jaccard_groups_10625 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_34696 280.41 +- 130.12 2 0 0 0 0.07 +- 0.12 2 12

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (2/2) NMT1/THI5 like
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00296 (2/2) Luciferase-like monooxygenase
PF00248 (2/2) Aldo/keto reductase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32107 62.30 +- 11.98 2 0 0 0 0.07 +- 0.04 2 11

TIGR01930 (2/2) acetyl-CoA C-acyltransferase
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00108 (2/2) Thiolase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_32453 98.70 +- 47.55 2 0 0 0 0.18 +- 0.27 2 11

TIGR01762 (2/2) chlorinating enzyme
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR01426 (1/2) glycosyltransferase, MGT family
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00975 (1/2) Thioesterase domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_38827 339.67 +- 75.22 2 0 0 0 0.07 +- 0.06 2 18

PF13672 (2/2) Protein phosphatase 2C
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01047 (2/2) MarR family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
TIGR03211 (1/2) catechol 2,3 dioxygenase
PF13796 (1/2) Putative sensor
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF00400 (1/2) WD domain, G-beta repeat
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_14532 117.18 +- 80.32 4 0 0 0 0.11 +- 0.21 4 11

PF12833 (4/4) Helix-turn-helix domain
PF02774 (4/4) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (4/4) DJ-1/PfpI family
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00171 (4/4) Aldehyde dehydrogenase family
PF00696 (3/4) Amino acid kinase family
TIGR01296 (2/4) aspartate-semialdehyde dehydrogenase
PF14742 (2/4) N-terminal domain of (some) glycogen debranching enzymes
PF13830 (2/4) Domain of unknown function (DUF4192)
precursor_jaccard_groups_2197 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_jaccard_groups_2196 513.39 +- 333.68 17 0 0 0 0.02 +- 0.01 17 8

PF07859 (17/17) alpha/beta hydrolase fold
PF07690 (17/17) Major Facilitator Superfamily
PF03959 (17/17) Serine hydrolase (FSH1)
PF01590 (17/17) GAF domain
PF00756 (17/17) Putative esterase
PF00561 (17/17) alpha/beta hydrolase fold
PF00196 (17/17) Bacterial regulatory proteins, luxR family
PF00144 (17/17) Beta-lactamase
precursor_jaccard_groups_38823 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF13185 (2/2) GAF domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_2194 164.03 +- 90.32 7 0 0 7 0.08 +- 0.20 7 8

TIGR04085 (7/7) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (7/7) Carbamoyltransferase C-terminus
PF07992 (7/7) Pyridine nucleotide-disulphide oxidoreductase
PF05977 (7/7) Transmembrane secretion effector
PF02543 (7/7) Carbamoyltransferase N-terminus
PF13186 (6/7) Iron-sulfur cluster-binding domain
PF05721 (6/7) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (4/7) Radical SAM superfamily
precursor_jaccard_groups_3024 44.72 +- 0.49 2 0 0 0 0.13 +- 0.21 2 2

PF01292 (2/2) Prokaryotic cytochrome b561
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
precursor_jaccard_groups_43086 846.72 +- 443.28 2 0 0 0 0.02 +- 0.01 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF07702 (2/2) UTRA domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35022 93.82 +- 0.00 2 0 2 0 0.09 +- 0.04 2 12

TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (2/2) Amino acid kinase family
PF00682 (2/2) HMGL-like
PF00501 (2/2) AMP-binding enzyme
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
PF00117 (2/2) Glutamine amidotransferase class-I
precursor_jaccard_groups_6035 918.88 +- 398.11 7 0 0 0 0.02 +- 0.01 7 10

PF13407 (7/7) Periplasmic binding protein domain
PF11721 (7/7) Malectin domain
PF10054 (7/7) Predicted periplasmic lipoprotein (DUF2291)
PF07632 (7/7) Protein of unknown function (DUF1593)
PF04198 (7/7) Putative sugar-binding domain
PF03422 (7/7) Carbohydrate binding module (family 6)
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF01261 (7/7) Xylose isomerase-like TIM barrel
PF00801 (7/7) PKD domain
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_9741 24.39 +- 5.96 2 0 0 0 0.09 +- 0.11 2 5

TIGR00099 (2/2) Cof-like hydrolase
PF12161 (2/2) HsdM N-terminal domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
precursor_jaccard_groups_6037 820.61 +- 469.39 2 0 1 2 0.03 +- 0.05 2 6

PF13471 (2/2) Transglutaminase-like superfamily
PF00400 (2/2) WD domain, G-beta repeat
PF00326 (2/2) Prolyl oligopeptidase family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
precursor_jaccard_groups_13538 620.20 +- 241.60 4 0 1 0 0.01 +- 0.00 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00975 (4/4) Thioesterase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_18439 207.00 +- 16.07 3 0 0 0 0.05 +- 0.07 3 16

PF11308 (3/3) Glycosyl hydrolases related to GH101 family, GH129
PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF04185 (3/3) Phosphoesterase family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00171 (3/3) Aldehyde dehydrogenase family
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_7031 19.67 +- 5.92 6 0 0 0 0.13 +- 0.09 6 4

PF17801 (6/6) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (6/6) Alpha galactosidase A
PF09206 (6/6) Alpha-L-arabinofuranosidase B, catalytic
PF00652 (6/6) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_15 134.88 +- 15.76 4 0 0 0 0.20 +- 0.33 4 7

TIGR01915 (4/4) NADPH-dependent F420 reductase
PF13560 (4/4) Helix-turn-helix domain
PF13088 (4/4) BNR repeat-like domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_5255 53.22 +- 31.75 5 0 4 0 0.16 +- 0.20 5 6

PF05331 (5/5) Protein of unknown function (DUF742)
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF11991 (4/5) Tryptophan dimethylallyltransferase
PF01212 (4/5) Beta-eliminating lyase
precursor_jaccard_groups_10192 95.66 +- 39.40 5 0 5 5 0.14 +- 0.10 5 12

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (5/5) ABC-2 type transporter
PF00881 (5/5) Nitroreductase family
PF00005 (5/5) ABC transporter
TIGR03605 (3/5) SagB-type dehydrogenase domain
PF03704 (3/5) Bacterial transcriptional activator domain
PF00931 (3/5) NB-ARC domain
PF00486 (3/5) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_31928 36.07 +- 2.63 2 0 0 0 0.08 +- 0.06 2 8

PF13493 (2/2) Domain of unknown function (DUF4118)
PF06304 (2/2) Protein of unknown function (DUF1048)
PF03551 (2/2) Transcriptional regulator PadR-like family
PF02702 (2/2) Osmosensitive K+ channel His kinase sensor domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02254 (2/2) TrkA-N domain
PF00582 (2/2) Universal stress protein family
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
precursor_jaccard_groups_6299 94.51 +- 57.36 6 0 0 0 0.03 +- 0.02 6 1

PF01833 (6/6) IPT/TIG domain
precursor_jaccard_groups_31255 37.05 +- 2.65 2 0 0 0 0.11 +- 0.13 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00668 (2/2) Condensation domain
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_6296 87.80 +- 51.42 7 0 0 0 0.08 +- 0.09 7 12

TIGR03945 (7/7) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (7/7) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (7/7) amidohydrolase
TIGR00843 (7/7) benzoate transporter
PF13454 (7/7) FAD-NAD(P)-binding
PF13424 (7/7) Tetratricopeptide repeat
PF03594 (7/7) Benzoate membrane transport protein
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (7/7) Peptidase family M20/M25/M40
PF01053 (7/7) Cys/Met metabolism PLP-dependent enzyme
PF00931 (7/7) NB-ARC domain
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_36248 456.07 +- 52.62 2 0 0 0 0.01 +- 0.01 2 15

TIGR00364 (2/2) queuosine biosynthesis protein QueC
PF13692 (2/2) Glycosyl transferases group 1
PF13439 (2/2) Glycosyltransferase Family 4
PF13394 (2/2) 4Fe-4S single cluster domain
PF13242 (2/2) HAD-hyrolase-like
PF08889 (2/2) WbqC-like protein family
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF02739 (2/2) 5'-3' exonuclease, N-terminal resolvase-like domain
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01367 (2/2) 5'-3' exonuclease, C-terminal SAM fold
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00534 (2/2) Glycosyl transferases group 1
PF00156 (2/2) Phosphoribosyl transferase domain
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
precursor_jaccard_groups_23052 172.33 +- 60.58 3 0 1 0 0.02 +- 0.02 3 2

PF04299 (3/3) Putative FMN-binding domain
PF01494 (3/3) FAD binding domain
precursor_jaccard_groups_23721 95.24 +- 15.97 2 0 0 0 0.05 +- 0.04 2 5

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF01457 (2/2) Leishmanolysin
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_36228 412.94 +- 0.00 2 0 0 0 0.03 +- 0.02 2 11

PF13407 (2/2) Periplasmic binding protein domain
PF07729 (2/2) FCD domain
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01979 (2/2) Amidohydrolase family
PF01968 (2/2) Hydantoinase/oxoprolinase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35157 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_7749 30.65 +- 2.87 4 0 0 0 0.20 +- 0.25 4 7

PF13510 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF05544 (4/4) Proline racemase
PF04324 (4/4) BFD-like [2Fe-2S] binding domain
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01266 (4/4) FAD dependent oxidoreductase
PF00701 (4/4) Dihydrodipicolinate synthetase family
precursor_jaccard_groups_42358 150.03 +- 21.03 2 0 1 0 0.03 +- 0.01 2 6

TIGR03618 (2/2) PPOX class probable F420-dependent enzyme
PF08031 (2/2) Berberine and berberine like
PF07690 (2/2) Major Facilitator Superfamily
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_39791 36.01 +- 5.05 2 0 2 0 0.11 +- 0.13 2 4

PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00722 (2/2) Glycosyl hydrolases family 16
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_3594 50.58 +- 29.35 3 0 0 0 0.07 +- 0.12 3 3

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07920 (3/3) Protein of unknown function (DUF1684)
PF00296 (3/3) Luciferase-like monooxygenase
precursor_jaccard_groups_7107 106.59 +- 14.82 2 0 0 0 0.08 +- 0.07 2 8

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF13602 (2/2) Zinc-binding dehydrogenase
PF08281 (2/2) Sigma-70, region 4
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF04542 (2/2) Sigma-70 region 2
PF01425 (2/2) Amidase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1414 87.05 +- 60.96 10 0 10 0 0.04 +- 0.04 10 9

PF16197 (10/10) Ketoacyl-synthetase C-terminal extension
PF14765 (10/10) Polyketide synthase dehydratase
PF08659 (10/10) KR domain
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF00698 (10/10) Acyl transferase domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00107 (10/10) Zinc-binding dehydrogenase
PF08240 (9/10) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_6728 13.47 +- 0.47 2 0 0 0 0.15 +- 0.03 2 2

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
precursor_jaccard_groups_23298 24.96 +- 6.24 2 0 0 0 0.18 +- 0.33 2 4

PF06259 (2/2) Alpha/beta hydrolase
PF01569 (2/2) PAP2 superfamily
PF01464 (2/2) Transglycosylase SLT domain
PF00877 (2/2) NlpC/P60 family
precursor_jaccard_groups_6724 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_jaccard_groups_6725 245.38 +- 147.97 7 0 0 0 0.02 +- 0.01 7 4

PF03737 (7/7) Aldolase/RraA
PF00994 (7/7) Probable molybdopterin binding domain
PF00682 (7/7) HMGL-like
PF00180 (7/7) Isocitrate/isopropylmalate dehydrogenase
precursor_jaccard_groups_36915 464.29 +- 204.29 2 0 2 0 0.02 +- 0.01 2 8

TIGR00808 (2/2) malonate transporter, MadM subunit
TIGR00807 (2/2) malonate transporter, MadL subunit
PF17408 (2/2) Malonyl-CoA decarboxylase N-terminal domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05292 (2/2) Malonyl-CoA decarboxylase C-terminal domain
PF03818 (2/2) Malonate/sodium symporter MadM subunit
PF03817 (2/2) Malonate transporter MadL subunit
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_13407 1191.19 +- 1181.25 4 1 1 4 0.05 +- 0.18 3 22

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/4) Methyltransferase domain
PF07993 (4/4) Male sterility protein
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF03176 (4/4) MMPL family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/4) MOSC domain
PF01575 (3/4) MaoC like domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF05193 (2/4) Peptidase M16 inactive domain
PF03476 (2/4) MOSC N-terminal beta barrel domain
PF00106 (2/4) short chain dehydrogenase
precursor_jaccard_groups_43883 53.52 +- 0.01 2 0 2 0 0.15 +- 0.35 2 9

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02441 (2/2) Flavoprotein
PF01575 (2/2) MaoC like domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_6723 74.03 +- 22.04 3 0 0 0 0.05 +- 0.07 3 9

PF13091 (3/3) PLD-like domain
PF03176 (3/3) MMPL family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01569 (3/3) PAP2 superfamily
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00144 (3/3) Beta-lactamase
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_18298 10.28 +- 0.64 3 0 3 0 0.20 +- 0.34 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF03621 (3/3) MbtH-like protein
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_15664 47.22 +- 21.71 3 0 3 0 0.07 +- 0.08 3 2

PF11991 (3/3) Tryptophan dimethylallyltransferase
PF01212 (3/3) Beta-eliminating lyase
precursor_jaccard_groups_15665 54.12 +- 15.76 2 0 2 0 0.19 +- 0.31 2 15

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_11370 107.92 +- 55.70 3 0 0 0 0.06 +- 0.05 3 4

PF13377 (3/3) Periplasmic binding protein-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF01301 (3/3) Glycosyl hydrolases family 35
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_11372 32.20 +- 11.98 3 0 0 0 0.12 +- 0.23 3 5

TIGR02246 (3/3) conserved hypothetical protein
PF14534 (3/3) Domain of unknown function (DUF4440)
PF04149 (3/3) Domain of unknown function (DUF397)
PF01738 (3/3) Dienelactone hydrolase family
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_10287 533.02 +- 637.84 5 0 0 0 0.01 +- 0.00 5 3

TIGR03930 (5/5) WXG100 family type VII secretion target
PF06013 (5/5) Proteins of 100 residues with WXG
PF00082 (5/5) Subtilase family
precursor_jaccard_groups_33278 639.76 +- 576.52 2 0 2 0 0.02 +- 0.03 2 10

TIGR01136 (2/2) cysteine synthase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01361 (2/2) Tautomerase enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF03358 (1/2) NADPH-dependent FMN reductase
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01071 (1/2) Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_18297 2825.68 +- 2800.07 3 0 3 2 0.08 +- 0.23 3 16

TIGR01733 (3/3) amino acid adenylation domain
TIGR01720 (3/3) non-ribosomal peptide synthase domain TIGR01720
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12679 (3/3) ABC-2 family transporter protein
PF08241 (3/3) Methyltransferase domain
PF07730 (3/3) Histidine kinase
PF06722 (3/3) Protein of unknown function (DUF1205)
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
PF00733 (2/3) Asparagine synthase
precursor_jaccard_groups_27802 239.03 +- 147.97 2 0 1 0 0.02 +- 0.03 2 3

PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF07690 (2/2) Major Facilitator Superfamily
PF00487 (2/2) Fatty acid desaturase
precursor_jaccard_groups_41232 354.97 +- 8.87 2 0 0 0 0.03 +- 0.01 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_4479 56.76 +- 14.01 4 0 0 0 0.25 +- 0.30 4 12

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
PF18029 (4/4) Glyoxalase-like domain
PF12704 (4/4) MacB-like periplasmic core domain
PF12697 (4/4) Alpha/beta hydrolase family
PF08281 (4/4) Sigma-70, region 4
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07730 (4/4) Histidine kinase
PF04542 (4/4) Sigma-70 region 2
PF02687 (4/4) FtsX-like permease family
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_6500 167.62 +- 107.23 7 0 0 0 0.04 +- 0.12 7 5

PF09587 (7/7) Bacterial capsule synthesis protein PGA_cap
PF08386 (7/7) TAP-like protein
PF00561 (7/7) alpha/beta hydrolase fold
PF00348 (7/7) Polyprenyl synthetase
PF00144 (7/7) Beta-lactamase
precursor_jaccard_groups_15462 43.53 +- 3.38 2 0 0 0 0.18 +- 0.09 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_27778 226.75 +- 33.25 2 0 0 0 0.01 +- 0.00 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13365 (2/2) Trypsin-like peptidase domain
PF13191 (2/2) AAA ATPase domain
PF10503 (2/2) Esterase PHB depolymerase
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_2861 801.15 +- 1050.38 13 0 0 0 0.02 +- 0.02 13 6

TIGR03930 (13/13) WXG100 family type VII secretion target
TIGR03919 (13/13) type VII secretion protein EccB
PF06013 (13/13) Proteins of 100 residues with WXG
PF05108 (13/13) Type VII secretion system ESX-1, transport TM domain B
TIGR03921 (12/13) type VII secretion-associated serine protease mycosin
PF00082 (12/13) Subtilase family
precursor_jaccard_groups_1562 16.19 +- 0.13 4 0 4 0 0.19 +- 0.30 4 4

PF10935 (4/4) Protein of unknown function (DUF2637)
PF05331 (4/4) Protein of unknown function (DUF742)
PF03259 (4/4) Roadblock/LC7 domain
PF03029 (4/4) Conserved hypothetical ATP binding protein
precursor_jaccard_groups_1560 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein
precursor_jaccard_groups_18619 100.21 +- 6.13 3 0 0 0 0.15 +- 0.13 3 16

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF05025 (3/3) RbsD / FucU transport protein family
PF04909 (3/3) Amidohydrolase
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00248 (3/3) Aldo/keto reductase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_41522 35.57 +- 19.46 2 0 0 0 0.18 +- 0.21 2 8

PF13649 (2/2) Methyltransferase domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF12840 (1/2) Helix-turn-helix domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF00384 (1/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_18343 719.48 +- 312.52 2 0 2 0 0.02 +- 0.01 2 8

PF13452 (2/2) N-terminal half of MaoC dehydratase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF01575 (2/2) MaoC like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00890 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_1569 19.78 +- 1.72 2 0 1 0 0.15 +- 0.21 2 4

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00293 (1/2) NUDIX domain
precursor_jaccard_groups_21965 45.54 +- 25.47 3 0 0 0 0.11 +- 0.14 3 5

TIGR03666 (3/3) PPOX class probable F420-dependent enzyme, Rv2061 family
PF07690 (3/3) Major Facilitator Superfamily
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_33674 1340.26 +- 160.83 2 0 0 0 0.01 +- 0.01 2 8

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_8838 17.54 +- 8.83 4 0 4 0 0.18 +- 0.25 4 14

PF12740 (4/4) Chlorophyllase enzyme
PF12697 (4/4) Alpha/beta hydrolase family
PF06386 (4/4) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (4/4) Gas vesicle synthesis protein GvpO
PF05121 (4/4) Gas vesicle protein K
PF05120 (4/4) Gas vesicle protein G
PF00741 (4/4) Gas vesicle protein
PF00561 (4/4) alpha/beta hydrolase fold
TIGR03086 (2/4) TIGR03086 family protein
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF11716 (2/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11611 (2/4) Domain of unknown function (DUF4352)
PF07690 (2/4) Major Facilitator Superfamily
PF00730 (2/4) HhH-GPD superfamily base excision DNA repair protein
precursor_jaccard_groups_18157 486.75 +- 211.32 3 0 3 0 0.01 +- 0.01 3 4

PF11706 (3/3) CGNR zinc finger
PF01713 (3/3) Smr domain
PF01596 (3/3) O-methyltransferase
PF01494 (3/3) FAD binding domain
precursor_jaccard_groups_31812 214.79 +- 47.95 2 0 0 0 0.08 +- 0.07 2 9

TIGR01234 (2/2) ribulokinase
PF13407 (2/2) Periplasmic binding protein domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_23123 915.58 +- 610.36 3 0 3 0 0.09 +- 0.22 3 15

TIGR01733 (3/3) amino acid adenylation domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF04339 (3/3) Peptidogalycan biosysnthesis/recognition
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01061 (3/3) ABC-2 type transporter
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_11579 374.56 +- 149.41 4 0 3 0 0.02 +- 0.06 4 7

PF13649 (4/4) Methyltransferase domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF12850 (4/4) Calcineurin-like phosphoesterase superfamily domain
PF04389 (4/4) Peptidase family M28
PF01663 (4/4) Type I phosphodiesterase / nucleotide pyrophosphatase
PF00334 (4/4) Nucleoside diphosphate kinase
PF00155 (4/4) Aminotransferase class I and II
precursor_jaccard_groups_36171 107.04 +- 3.67 2 0 0 0 0.10 +- 0.27 2 12

TIGR01141 (2/2) histidinol-phosphate transaminase
TIGR00797 (2/2) MATE efflux family protein
PF14269 (2/2) Arylsulfotransferase (ASST)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF01497 (2/2) Periplasmic binding protein
PF00860 (2/2) Permease family
PF00664 (2/2) ABC transporter transmembrane region
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10556 11.52 +- 3.85 3 0 0 0 0.19 +- 0.22 3 5

TIGR00537 (3/3) putative methylase
PF09360 (3/3) Iron-binding zinc finger CDGSH type
PF05175 (3/3) Methyltransferase small domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00355 (3/3) Rieske [2Fe-2S] domain
precursor_jaccard_groups_33414 14.99 +- 0.81 2 0 0 0 0.13 +- 0.17 2 3

PF16375 (2/2) Domain of unknown function
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
precursor_jaccard_groups_5679 84.52 +- 19.96 8 0 0 0 0.15 +- 0.27 8 14

TIGR03083 (8/8) uncharacterized Actinobacterial protein TIGR03083
PF13354 (8/8) Beta-lactamase enzyme family
PF09423 (8/8) PhoD-like phosphatase
PF09339 (8/8) IclR helix-turn-helix domain
PF08402 (8/8) TOBE domain
PF02894 (8/8) Oxidoreductase family, C-terminal alpha/beta domain
PF02826 (8/8) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01614 (8/8) Bacterial transcriptional regulator
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF13581 (7/8) Histidine kinase-like ATPase domain
PF01547 (6/8) Bacterial extracellular solute-binding protein
PF01370 (6/8) NAD dependent epimerase/dehydratase family
precursor_jaccard_groups_37179 117.38 +- 3.56 2 0 0 0 0.03 +- 0.02 2 7

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13545 (2/2) Crp-like helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF00702 (1/2) haloacid dehalogenase-like hydrolase
precursor_jaccard_groups_7819 26.87 +- 15.22 3 0 0 0 0.13 +- 0.13 3 2

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF01872 (3/3) RibD C-terminal domain
precursor_jaccard_groups_7818 25.47 +- 0.05 2 0 0 0 0.24 +- 0.13 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13426 (2/2) PAS domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04616 (2/2) Glycosyl hydrolases family 43
PF01095 (2/2) Pectinesterase
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_36689 14.41 +- 0.48 2 0 2 0 0.14 +- 0.01 2 4

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02633 (2/2) Creatinine amidohydrolase
PF01042 (2/2) Endoribonuclease L-PSP
precursor_jaccard_groups_37950 418.90 +- 234.16 2 0 1 0 0.03 +- 0.04 2 8

PF14031 (2/2) Putative serine dehydratase domain
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13309 (1/2) HTH domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF08348 (1/2) YheO-like PAS domain
PF04235 (1/2) Protein of unknown function (DUF418)
precursor_jaccard_groups_8121 264.71 +- 55.43 6 0 0 0 0.04 +- 0.03 6 8

PF13378 (6/6) Enolase C-terminal domain-like
PF07729 (6/6) FCD domain
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00754 (6/6) F5/8 type C domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00480 (6/6) ROK family
PF00392 (6/6) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_1340 13.15 +- 4.71 7 0 0 0 0.21 +- 0.11 7 2

PF03067 (7/7) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (7/7) SPFH domain / Band 7 family
precursor_jaccard_groups_7814 216.46 +- 59.99 6 0 0 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (6/6) YbaB/EbfC DNA-binding family
PF04488 (5/6) Glycosyltransferase sugar-binding region containing DXD motif
precursor_jaccard_groups_39715 51.07 +- 35.59 2 0 0 0 0.08 +- 0.05 2 3

TIGR01733 (2/2) amino acid adenylation domain
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_36680 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
precursor_jaccard_groups_20963 151.24 +- 56.75 3 0 3 0 0.03 +- 0.02 3 14

TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF09335 (3/3) SNARE associated Golgi protein
PF08659 (3/3) KR domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_10178 204.73 +- 99.57 4 0 2 0 0.08 +- 0.07 4 22

TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF08713 (4/4) DNA alkylation repair enzyme
PF08659 (4/4) KR domain
PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01494 (4/4) FAD binding domain
PF00975 (4/4) Thioesterase domain
PF00850 (4/4) Histone deacetylase domain
PF00848 (4/4) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (4/4) Acyl transferase domain
PF00551 (4/4) Formyl transferase
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00155 (4/4) Aminotransferase class I and II
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF18029 (2/4) Glyoxalase-like domain
PF07478 (2/4) D-ala D-ala ligase C-terminus
PF01820 (2/4) D-ala D-ala ligase N-terminus
precursor_jaccard_groups_12668 377.12 +- 191.17 4 0 4 0 0.03 +- 0.02 4 9

PF16861 (4/4) Carbamoyltransferase C-terminus
PF13560 (4/4) Helix-turn-helix domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF02543 (4/4) Carbamoyltransferase N-terminus
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_12667 172.67 +- 61.75 3 0 3 0 0.01 +- 0.00 3 3

PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/3) Phosphopantetheine attachment site
precursor_jaccard_groups_32022 11.59 +- 1.76 2 0 0 0 0.18 +- 0.03 2 12

TIGR03424 (2/2) urea carboxylase-associated protein 1
TIGR02713 (2/2) allophanate hydrolase
TIGR02712 (2/2) urea carboxylase
PF09347 (2/2) Domain of unknown function (DUF1989)
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (2/2) Biotin carboxylase C-terminal domain
PF02682 (2/2) Carboxyltransferase domain, subdomain C and D
PF02626 (2/2) Carboxyltransferase domain, subdomain A and B
PF01425 (2/2) Amidase
PF00364 (2/2) Biotin-requiring enzyme
PF00289 (2/2) Biotin carboxylase, N-terminal domain
TIGR03425 (1/2) urea carboxylase-associated protein 2
precursor_jaccard_groups_10170 153.06 +- 34.46 4 0 4 0 0.06 +- 0.13 4 25

TIGR01762 (4/4) chlorinating enzyme
TIGR01733 (4/4) amino acid adenylation domain
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01444 (4/4) methyltransferase, FkbM family
TIGR00843 (4/4) benzoate transporter
PF16990 (4/4) Carbohydrate binding module (family 35)
PF13560 (4/4) Helix-turn-helix domain
PF13535 (4/4) ATP-grasp domain
PF13454 (4/4) FAD-NAD(P)-binding
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07691 (4/4) PA14 domain
PF06439 (4/4) Domain of Unknown Function (DUF1080)
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/4) Methyltransferase FkbM domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF03594 (4/4) Benzoate membrane transport protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_10172 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_22934 1877.33 +- 808.40 3 0 0 0 0.01 +- 0.01 3 28

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
TIGR00481 (3/3) Raf kinase inhibitor-like protein, YbhB/YbcL family
PF14765 (3/3) Polyketide synthase dehydratase
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF12697 (3/3) Alpha/beta hydrolase family
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF08659 (3/3) KR domain
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF06684 (3/3) Amino acid synthesis
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01614 (3/3) Bacterial transcriptional regulator
PF01554 (3/3) MatE
PF01494 (3/3) FAD binding domain
PF01161 (3/3) Phosphatidylethanolamine-binding protein
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_5074 130.83 +- 75.85 4 0 0 0 0.02 +- 0.01 4 2

PF03795 (4/4) YCII-related domain
PF01425 (4/4) Amidase
precursor_jaccard_groups_5076 631.51 +- 339.98 9 0 0 9 0.02 +- 0.01 9 12

TIGR01733 (9/9) amino acid adenylation domain
TIGR00702 (9/9) YcaO-type kinase domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07812 (9/9) TfuA-like protein
PF07690 (9/9) Major Facilitator Superfamily
PF05721 (9/9) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (9/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_21186 21.60 +- 13.06 2 0 0 0 0.16 +- 0.30 2 5

PF08376 (2/2) Nitrate and nitrite sensing
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_1535 38.68 +- 23.99 6 0 0 0 0.22 +- 0.38 6 12

TIGR01525 (6/6) heavy metal translocating P-type ATPase
PF03965 (6/6) Penicillinase repressor
PF01435 (6/6) Peptidase family M48
PF00702 (6/6) haloacid dehalogenase-like hydrolase
PF00403 (6/6) Heavy-metal-associated domain
PF00122 (6/6) E1-E2 ATPase
PF13649 (3/6) Methyltransferase domain
PF12697 (3/6) Alpha/beta hydrolase family
PF02583 (3/6) Metal-sensitive transcriptional repressor
PF01475 (3/6) Ferric uptake regulator family
PF00583 (3/6) Acetyltransferase (GNAT) family
PF00196 (3/6) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_45209 103.84 +- 33.99 2 0 2 0 0.06 +- 0.13 2 14

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_41419 1300.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13474 (2/2) SnoaL-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07729 (2/2) FCD domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_8017 952.16 +- 734.28 6 0 0 0 0.04 +- 0.14 6 13

TIGR01726 (6/6) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF17853 (6/6) GGDEF-like domain
PF13556 (6/6) PucR C-terminal helix-turn-helix domain
PF07978 (6/6) NIPSNAP
PF07969 (6/6) Amidohydrolase family
PF02627 (6/6) Carboxymuconolactone decarboxylase family
PF01613 (6/6) Flavin reductase like domain
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00497 (6/6) Bacterial extracellular solute-binding proteins, family 3
PF00296 (6/6) Luciferase-like monooxygenase
PF00264 (6/6) Common central domain of tyrosinase
PF00171 (6/6) Aldehyde dehydrogenase family
PF00005 (6/6) ABC transporter
precursor_jaccard_groups_37316 22.89 +- 3.64 2 0 0 0 0.20 +- 0.37 2 7

PF13365 (2/2) Trypsin-like peptidase domain
PF05685 (2/2) Putative restriction endonuclease
PF01569 (2/2) PAP2 superfamily
PF01464 (2/2) Transglycosylase SLT domain
PF00877 (2/2) NlpC/P60 family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF00069 (1/2) Protein kinase domain
precursor_jaccard_groups_12110 59.35 +- 34.78 2 0 0 0 0.13 +- 0.18 2 7

PF13091 (2/2) PLD-like domain
PF11907 (2/2) Domain of unknown function (DUF3427)
PF04851 (2/2) Type III restriction enzyme, res subunit
PF02810 (2/2) SEC-C motif
PF00296 (2/2) Luciferase-like monooxygenase
PF00271 (2/2) Helicase conserved C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_37314 2015.00 +- 65.00 2 0 0 0 0.01 +- 0.00 2 19

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16353 (2/2) Domain of unknown function(DUF4981)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF01370 (1/2) NAD dependent epimerase/dehydratase family
precursor_jaccard_groups_36772 25.41 +- 6.29 2 0 0 0 0.08 +- 0.08 2 5

TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF04978 (2/2) Protein of unknown function (DUF664)
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
precursor_jaccard_groups_33307 240.06 +- 154.43 2 0 0 0 0.07 +- 0.12 2 6

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_15715 21.63 +- 4.99 2 0 0 0 0.23 +- 0.33 2 16

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR01411 (2/2) twin arginine-targeting protein translocase, TatA/E family
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF07510 (2/2) Protein of unknown function (DUF1524)
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02416 (2/2) mttA/Hcf106 family
PF02342 (2/2) TerD domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01524 (1/2) magnesium-translocating P-type ATPase
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00690 (1/2) Cation transporter/ATPase, N-terminus
PF00689 (1/2) Cation transporting ATPase, C-terminus
PF00122 (1/2) E1-E2 ATPase
precursor_jaccard_groups_21506 16.48 +- 0.00 2 0 0 0 0.18 +- 0.21 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF01513 (2/2) ATP-NAD kinase
PF01145 (2/2) SPFH domain / Band 7 family
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_16102 18.33 +- 4.51 2 0 2 0 0.19 +- 0.29 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03176 (2/2) MMPL family
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13426 (1/2) PAS domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01590 (1/2) GAF domain
PF00989 (1/2) PAS fold
precursor_jaccard_groups_24828 1529.06 +- 164.06 2 0 2 2 0.01 +- 0.00 2 12

TIGR03605 (2/2) SagB-type dehydrogenase domain
PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04072 (2/2) Leucine carboxyl methyltransferase
PF04055 (2/2) Radical SAM superfamily
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02441 (2/2) Flavoprotein
PF02195 (2/2) ParB-like nuclease domain
PF00881 (2/2) Nitroreductase family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF06779 (1/2) Uncharacterised MFS-type transporter YbfB
precursor_jaccard_groups_16101 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_jaccard_groups_22234 206.04 +- 127.96 3 0 3 2 0.03 +- 0.04 3 10

PF17668 (3/3) Acetyltransferase (GNAT) domain
PF13530 (3/3) Sterol carrier protein domain
PF13527 (3/3) Acetyltransferase (GNAT) domain
PF07690 (3/3) Major Facilitator Superfamily
PF00553 (3/3) Cellulose binding domain
PF00457 (3/3) Glycosyl hydrolases family 11
PF05147 (2/3) Lanthionine synthetase C-like protein
PF02909 (2/3) Tetracyclin repressor-like, C-terminal domain
PF01636 (2/3) Phosphotransferase enzyme family
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_21435 10.00 +- 1.15 3 0 0 0 0.20 +- 0.20 3 4

PF16113 (3/3) Enoyl-CoA hydratase/isomerase
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_19369 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
precursor_jaccard_groups_26423 60.31 +- 19.69 2 0 0 0 0.07 +- 0.04 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_11399 95.56 +- 47.30 3 0 0 0 0.03 +- 0.04 3 3

PF02515 (3/3) CoA-transferase family III
PF00082 (3/3) Subtilase family
PF05425 (2/3) Copper resistance protein D
precursor_jaccard_groups_20817 17.66 +- 2.35 3 0 0 0 0.12 +- 0.15 3 3

PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01427 (3/3) D-ala-D-ala dipeptidase
PF00795 (3/3) Carbon-nitrogen hydrolase
precursor_jaccard_groups_25331 11.51 +- 1.71 2 0 0 0 0.18 +- 0.07 2 5

TIGR03802 (2/2) aspartate-alanine antiporter
TIGR03801 (2/2) aspartate 4-decarboxylase
PF06826 (2/2) Predicted Permease Membrane Region
PF02080 (2/2) TrkA-C domain
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_12596 23.44 +- 7.52 2 0 0 0 0.17 +- 0.16 2 8

PF17754 (2/2) MftR C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08445 (2/2) FR47-like protein
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_33099 68.66 +- 7.23 2 0 2 0 0.03 +- 0.03 2 5

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF05977 (2/2) Transmembrane secretion effector
PF00400 (2/2) WD domain, G-beta repeat
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_33095 69.96 +- 24.43 2 0 0 2 0.05 +- 0.09 2 11

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_29992 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_37089 569.60 +- 92.22 2 0 0 0 0.03 +- 0.02 2 15

TIGR00217 (2/2) 4-alpha-glucanotransferase
PF08323 (2/2) Starch synthase catalytic domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07883 (2/2) Cupin domain
PF06182 (2/2) ABC-2 family transporter protein
PF04321 (2/2) RmlD substrate binding domain
PF02446 (2/2) 4-alpha-glucanotransferase
PF01761 (2/2) 3-dehydroquinate synthase
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR01484 (1/2) HAD hydrolase, family IIB
TIGR00099 (1/2) Cof-like hydrolase
precursor_jaccard_groups_11150 18.69 +- 4.79 4 0 4 4 0.17 +- 0.13 4 7

TIGR04187 (4/4) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (4/4) putative ATP-grasp target RiPP
TIGR03943 (4/4) TIGR03943 family protein
PF14404 (4/4) Ribosomally synthesized peptide in Streptomyces species
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF03773 (4/4) Predicted permease
PF02852 (4/4) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
precursor_jaccard_groups_18960 297.50 +- 79.66 3 0 3 0 0.01 +- 0.01 3 5

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_25336 16.61 +- 3.50 2 0 0 0 0.19 +- 0.25 2 8

TIGR01472 (2/2) GDP-mannose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF04149 (2/2) Domain of unknown function (DUF397)
PF00535 (2/2) Glycosyl transferase family 2
PF13560 (1/2) Helix-turn-helix domain
PF00872 (1/2) Transposase, Mutator family
PF00561 (1/2) alpha/beta hydrolase fold
PF00069 (1/2) Protein kinase domain
precursor_jaccard_groups_15901 365.31 +- 284.69 2 0 0 0 0.03 +- 0.05 2 3

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase
precursor_jaccard_groups_32841 1161.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 11

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13279 (2/2) Thioesterase-like superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_9043 11.03 +- 3.58 3 0 0 0 0.22 +- 0.18 3 5

PF02803 (3/3) Thiolase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_jaccard_groups_5406 703.23 +- 330.82 8 0 3 0 0.01 +- 0.01 8 9

PF18603 (8/8) L-amino acid ligase C-terminal domain 2
PF18130 (8/8) ATP-grasp N-terminal domain
PF13535 (8/8) ATP-grasp domain
PF01212 (8/8) Beta-eliminating lyase
PF00501 (8/8) AMP-binding enzyme
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF00288 (8/8) GHMP kinases N terminal domain
PF00206 (8/8) Lyase
PF00067 (8/8) Cytochrome P450
precursor_jaccard_groups_28971 97.11 +- 11.53 2 0 0 0 0.17 +- 0.23 2 22

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02065 (2/2) Melibiase
PF01799 (2/2) [2Fe-2S] binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01081 (2/2) KDPG and KHG aldolase
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_5400 75.72 +- 9.61 8 0 8 0 0.04 +- 0.05 8 5

PF13394 (8/8) 4Fe-4S single cluster domain
PF13377 (8/8) Periplasmic binding protein-like domain
PF01242 (8/8) 6-pyruvoyl tetrahydropterin synthase
PF01227 (8/8) GTP cyclohydrolase I
PF00356 (8/8) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_2843 2098.06 +- 1653.57 13 4 9 13 0.01 +- 0.00 9 8

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (13/13) SagB-type dehydrogenase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/13) Nitroreductase family
PF00067 (12/13) Cytochrome P450
PF04738 (10/13) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_13887 82.80 +- 40.17 3 0 3 0 0.09 +- 0.18 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF03171 (3/3) 2OG-Fe(II) oxygenase superfamily
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00266 (3/3) Aminotransferase class-V
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_20745 390.00 +- 130.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR03571 (2/2) luciferase-type oxidoreductase, BA3436 family
PF01613 (2/2) Flavin reductase like domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_340 1929.46 +- 1553.11 79 0 63 51 0.03 +- 0.09 79 9

PF00005 (79/79) ABC transporter
PF00465 (78/79) Iron-containing alcohol dehydrogenase
PF00202 (78/79) Aminotransferase class-III
PF13649 (77/79) Methyltransferase domain
PF00296 (76/79) Luciferase-like monooxygenase
PF00069 (73/79) Protein kinase domain
PF05147 (48/79) Lanthionine synthetase C-like protein
PF00535 (46/79) Glycosyl transferase family 2
PF00483 (42/79) Nucleotidyl transferase
precursor_jaccard_groups_343 203.44 +- 178.34 29 0 29 0 0.12 +- 0.24 29 17

TIGR01188 (29/29) daunorubicin resistance ABC transporter, ATP-binding protein
PF03621 (29/29) MbtH-like protein
PF01061 (29/29) ABC-2 type transporter
PF00550 (29/29) Phosphopantetheine attachment site
PF00005 (29/29) ABC transporter
TIGR01733 (28/29) amino acid adenylation domain
PF00975 (28/29) Thioesterase domain
PF00501 (28/29) AMP-binding enzyme
TIGR03944 (27/29) 2,3-diaminopropionate biosynthesis protein SbnB
PF13193 (27/29) AMP-binding enzyme C-terminal domain
PF02423 (27/29) Ornithine cyclodeaminase/mu-crystallin family
PF00668 (27/29) Condensation domain
TIGR03945 (24/29) 2,3-diaminopropionate biosynthesis protein SbnA
PF00291 (24/29) Pyridoxal-phosphate dependent enzyme
TIGR01720 (23/29) non-ribosomal peptide synthase domain TIGR01720
PF13732 (16/29) Domain of unknown function (DUF4162)
PF00072 (15/29) Response regulator receiver domain
precursor_jaccard_groups_29228 731.71 +- 592.69 2 0 2 0 0.06 +- 0.06 2 16

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10862 (2/2) FcoT-like thioesterase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_20740 445.71 +- 74.29 2 0 2 0 0.01 +- 0.00 2 8

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_jaccard_groups_346 69.48 +- 79.53 68 0 68 68 0.08 +- 0.10 68 7

TIGR03882 (68/68) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (68/68) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (68/68) Histidine kinase
PF02624 (68/68) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (64/68) Bacterial regulatory proteins, luxR family
PF00072 (64/68) Response regulator receiver domain
PF12840 (62/68) Helix-turn-helix domain
precursor_jaccard_groups_21615 51.43 +- 5.90 2 0 0 0 0.04 +- 0.03 2 1

PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_9188 53.24 +- 23.79 5 0 5 0 0.09 +- 0.06 5 6

TIGR00797 (5/5) MATE efflux family protein
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (5/5) MatE
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_25548 53.33 +- 11.17 2 0 0 0 0.11 +- 0.16 2 15

PF14871 (2/2) Hypothetical glycosyl hydrolase 6
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13602 (2/2) Zinc-binding dehydrogenase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08532 (2/2) Beta-galactosidase trimerisation domain
PF08448 (2/2) PAS fold
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00989 (2/2) PAS fold
PF00457 (2/2) Glycosyl hydrolases family 11
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF03664 (1/2) Glycosyl hydrolase family 62
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_4553 205.04 +- 64.88 9 0 1 0 0.03 +- 0.08 9 7

TIGR03920 (9/9) type VII secretion integral membrane protein EccD
TIGR03919 (9/9) type VII secretion protein EccB
PF08817 (9/9) WXG100 protein secretion system (Wss), protein YukD
PF05108 (9/9) Type VII secretion system ESX-1, transport TM domain B
PF04488 (9/9) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (9/9) YbaB/EbfC DNA-binding family
PF07179 (8/9) SseB protein N-terminal domain
precursor_jaccard_groups_11026 187.85 +- 203.21 4 0 0 0 0.12 +- 0.29 4 6

TIGR01179 (4/4) UDP-glucose 4-epimerase GalE
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF02142 (4/4) MGS-like domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00994 (4/4) Probable molybdopterin binding domain
PF00724 (4/4) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_45337 176.07 +- 58.26 2 0 0 0 0.15 +- 0.33 2 27

TIGR02868 (2/2) thiol reductant ABC exporter, CydC subunit
TIGR02857 (2/2) thiol reductant ABC exporter, CydD subunit
TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00458 (2/2) aspartate--tRNA(Asn) ligase
TIGR00203 (2/2) cytochrome d ubiquinol oxidase, subunit II
PF13499 (2/2) EF-hand domain pair
PF13185 (2/2) GAF domain
PF12849 (2/2) PBP superfamily domain
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF07730 (2/2) Histidine kinase
PF05685 (2/2) Putative restriction endonuclease
PF04203 (2/2) Sortase domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02322 (2/2) Cytochrome bd terminal oxidase subunit II
PF01654 (2/2) Cytochrome bd terminal oxidase subunit I
PF01336 (2/2) OB-fold nucleic acid binding domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00672 (2/2) HAMP domain
PF00664 (2/2) ABC transporter transmembrane region
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF07411 (1/2) Domain of unknown function (DUF1508)
precursor_jaccard_groups_29197 101.74 +- 2.23 2 0 0 0 0.09 +- 0.15 2 10

PF12840 (2/2) Helix-turn-helix domain
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00582 (2/2) Universal stress protein family
PF00571 (2/2) CBS domain
PF00374 (2/2) Nickel-dependent hydrogenase
PF00361 (2/2) Proton-conducting membrane transporter
PF00346 (2/2) Respiratory-chain NADH dehydrogenase, 49 Kd subunit
PF00329 (2/2) Respiratory-chain NADH dehydrogenase, 30 Kd subunit
PF00146 (2/2) NADH dehydrogenase
precursor_jaccard_groups_29196 23.10 +- 1.60 2 0 0 0 0.13 +- 0.15 2 5

TIGR00127 (2/2) isocitrate dehydrogenase, NADP-dependent
PF13581 (2/2) Histidine kinase-like ATPase domain
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00484 (2/2) Carbonic anhydrase
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
precursor_jaccard_groups_38221 178.96 +- 22.96 2 0 0 0 0.10 +- 0.22 2 25

TIGR01792 (2/2) urease, alpha subunit
TIGR00836 (2/2) ammonium transporter
TIGR00193 (2/2) urease, gamma subunit
TIGR00192 (2/2) urease, beta subunit
TIGR00101 (2/2) urease accessory protein UreG
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF11941 (2/2) Domain of unknown function (DUF3459)
PF04041 (2/2) beta-1,4-mannooligosaccharide phosphorylase
PF03253 (2/2) Urea transporter
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01979 (2/2) Amidohydrolase family
PF01774 (2/2) UreD urease accessory protein
PF01730 (2/2) UreF
PF00909 (2/2) Ammonium Transporter Family
PF00699 (2/2) Urease beta subunit
PF00547 (2/2) Urease, gamma subunit
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00449 (2/2) Urease alpha-subunit, N-terminal domain
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
precursor_jaccard_groups_13082 37.34 +- 3.28 4 0 0 0 0.11 +- 0.13 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02781 (4/4) Glucose-6-phosphate dehydrogenase, C-terminal domain
PF00106 (4/4) short chain dehydrogenase
precursor_jaccard_groups_4942 25.88 +- 7.81 5 0 0 0 0.23 +- 0.31 5 14

TIGR01374 (5/5) sarcosine oxidase, delta subunit family
TIGR01373 (5/5) sarcosine oxidase, beta subunit family
TIGR01372 (5/5) sarcosine oxidase, alpha subunit family
PF17806 (5/5) Sarcosine oxidase A3 domain
PF13510 (5/5) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (5/5) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (5/5) Sarcosine oxidase, gamma subunit family
PF04267 (5/5) Sarcosine oxidase, delta subunit family
PF01571 (5/5) Aminomethyltransferase folate-binding domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00464 (5/5) Serine hydroxymethyltransferase
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF13340 (4/5) Putative transposase of IS4/5 family (DUF4096)
precursor_jaccard_groups_5092 24.90 +- 4.45 7 0 0 0 0.12 +- 0.10 7 3

PF04909 (7/7) Amidohydrolase
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF00248 (7/7) Aldo/keto reductase family
precursor_jaccard_groups_729 66.52 +- 25.83 31 0 0 0 0.17 +- 0.14 31 7

PF08532 (31/31) Beta-galactosidase trimerisation domain
PF02449 (31/31) Beta-galactosidase
PF01670 (31/31) Glycosyl hydrolase family 12
PF08533 (30/31) Beta-galactosidase C-terminal domain
PF00528 (30/31) Binding-protein-dependent transport system inner membrane component
PF14498 (28/31) Glycosyl hydrolase family 65, N-terminal domain
PF13416 (28/31) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_728 42.79 +- 18.19 10 0 1 0 0.13 +- 0.16 10 5

TIGR01484 (10/10) HAD hydrolase, family IIB
PF08282 (10/10) haloacid dehalogenase-like hydrolase
PF04149 (10/10) Domain of unknown function (DUF397)
PF00353 (10/10) RTX calcium-binding nonapeptide repeat (4 copies)
PF13560 (5/10) Helix-turn-helix domain
precursor_jaccard_groups_10996 18.87 +- 6.29 2 0 0 0 0.24 +- 0.19 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF03664 (2/2) Glycosyl hydrolase family 62
PF01341 (2/2) Glycosyl hydrolases family 6
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_28482 86.17 +- 42.83 2 0 0 0 0.03 +- 0.03 2 7

PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF07944 (1/2) Beta-L-arabinofuranosidase, GH127
precursor_jaccard_groups_234 148.16 +- 237.19 30 0 2 0 0.10 +- 0.17 30 5

PF14759 (30/30) Reductase C-terminal
PF07992 (30/30) Pyridine nucleotide-disulphide oxidoreductase
PF13370 (28/30) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (27/30) Cytochrome P450
PF00440 (15/30) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_17526 89.33 +- 31.49 3 0 0 0 0.19 +- 0.32 3 10

PF18844 (3/3) Bacterial archaeo-eukaryotic release factor family 2
PF13847 (3/3) Methyltransferase domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF11387 (3/3) Protein of unknown function (DUF2795)
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF01569 (3/3) PAP2 superfamily
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_6441 272.62 +- 115.74 5 0 5 0 0.04 +- 0.11 5 15

TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF05977 (5/5) Transmembrane secretion effector
PF03621 (5/5) MbtH-like protein
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00288 (5/5) GHMP kinases N terminal domain
PF00206 (5/5) Lyase
PF00975 (3/5) Thioesterase domain
precursor_jaccard_groups_28574 119.62 +- 68.02 2 0 0 0 0.05 +- 0.07 2 6

PF14759 (2/2) Reductase C-terminal
PF13459 (2/2) 4Fe-4S single cluster domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01636 (2/2) Phosphotransferase enzyme family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28575 24.60 +- 0.44 2 0 2 0 0.21 +- 0.12 2 7

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF11583 (1/2) P-aminobenzoate N-oxygenase AurF
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (1/2) 4Fe-4S binding domain
precursor_jaccard_groups_29575 317.93 +- 51.48 2 0 0 0 0.05 +- 0.07 2 7

PF13649 (2/2) Methyltransferase domain
PF08242 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01411 (2/2) tRNA synthetases class II (A)
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28573 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_15777 23.04 +- 0.00 2 0 0 0 0.13 +- 0.06 2 6

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02036 (2/2) SCP-2 sterol transfer family
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_4796 116.98 +- 50.55 3 0 0 0 0.04 +- 0.05 3 3

PF07702 (3/3) UTRA domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_5887 276.61 +- 111.60 8 0 8 0 0.02 +- 0.01 8 8

TIGR01733 (8/8) amino acid adenylation domain
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF12697 (8/8) Alpha/beta hydrolase family
PF02771 (8/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (8/8) Acyl-CoA dehydrogenase, middle domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00441 (8/8) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_28804 1290.00 +- 387.00 2 0 2 0 0.01 +- 0.02 2 20

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_30332 426.24 +- 257.68 2 0 2 0 0.05 +- 0.19 2 17

TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13460 (2/2) NAD(P)H-binding
PF13454 (2/2) FAD-NAD(P)-binding
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF07690 (2/2) Major Facilitator Superfamily
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR01796 (1/2) chorismate mutase
TIGR01358 (1/2) 3-deoxy-7-phosphoheptulonate synthase
PF07736 (1/2) Chorismate mutase type I
PF02153 (1/2) Prephenate dehydrogenase
PF01474 (1/2) Class-II DAHP synthetase family
precursor_jaccard_groups_28370 129.00 +- 0.00 2 0 2 2 0.02 +- 0.01 2 2

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
precursor_jaccard_groups_4046 94.89 +- 16.17 10 0 0 0 0.07 +- 0.04 10 10

TIGR03570 (10/10) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03025 (10/10) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF17836 (10/10) PglD N-terminal domain
PF13313 (10/10) Domain of unknown function (DUF4082)
PF13205 (10/10) Bacterial Ig-like domain
PF02397 (10/10) Bacterial sugar transferase
PF01408 (10/10) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (10/10) NAD dependent epimerase/dehydratase family
PF01041 (10/10) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (9/10) Glycosyl transferase family 2
precursor_jaccard_groups_45538 630.67 +- 401.33 2 0 2 0 0.02 +- 0.01 2 5

PF08241 (2/2) Methyltransferase domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03795 (2/2) YCII-related domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (2/2) Condensation domain
precursor_jaccard_groups_15118 50.34 +- 24.26 3 0 0 0 0.05 +- 0.02 3 3

PF02386 (3/3) Cation transport protein
PF02254 (3/3) TrkA-N domain
PF02080 (3/3) TrkA-C domain
precursor_jaccard_groups_16728 80.45 +- 41.36 3 0 2 0 0.16 +- 0.12 3 4

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF10091 (3/3) Putative glucoamylase
PF01229 (3/3) Glycosyl hydrolases family 39
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_40075 364.31 +- 25.69 2 0 0 0 0.01 +- 0.00 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_29281 62.67 +- 11.94 2 0 0 0 0.10 +- 0.14 2 7

PF13751 (2/2) Transposase DDE domain
PF12704 (2/2) MacB-like periplasmic core domain
PF05598 (2/2) Transposase domain (DUF772)
PF02687 (2/2) FtsX-like permease family
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_19812 18.76 +- 2.15 3 0 0 0 0.14 +- 0.18 3 6

TIGR02601 (3/3) autotransporter-associated beta strand repeat
PF12951 (3/3) Passenger-associated-transport-repeat
PF02366 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF01569 (3/3) PAP2 superfamily
PF01418 (3/3) Helix-turn-helix domain, rpiR family
PF01380 (2/3) SIS domain
precursor_jaccard_groups_3429 936.64 +- 1462.53 6 0 5 6 0.07 +- 0.14 6 13

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
PF03704 (6/6) Bacterial transcriptional activator domain
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00005 (6/6) ABC transporter
TIGR03892 (5/6) thiazolylpeptide-type bacteriocin precursor
TIGR03604 (5/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/6) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/6) Lantibiotic dehydratase, N terminus
PF01061 (5/6) ABC-2 type transporter
PF00881 (5/6) Nitroreductase family
TIGR01891 (4/6) amidohydrolase
PF01546 (4/6) Peptidase family M20/M25/M40
precursor_jaccard_groups_651 1344.03 +- 965.08 46 0 7 0 0.01 +- 0.01 46 5

PF00482 (46/46) Type II secretion system (T2SS), protein F
PF00437 (46/46) Type II/IV secretion system protein
PF08666 (45/46) SAF domain
PF07811 (45/46) TadE-like protein
PF01476 (38/46) LysM domain
precursor_jaccard_groups_20366 13.70 +- 3.21 3 0 0 0 0.15 +- 0.12 3 5

PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
precursor_jaccard_groups_20364 75.95 +- 28.25 3 0 0 0 0.03 +- 0.03 3 2

PF08241 (3/3) Methyltransferase domain
PF00334 (3/3) Nucleoside diphosphate kinase
precursor_jaccard_groups_35888 23.92 +- 0.98 2 0 0 0 0.13 +- 0.05 2 6

PF13183 (2/2) 4Fe-4S dicluster domain
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF01565 (2/2) FAD binding domain
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_40675 107.50 +- 21.50 2 0 0 0 0.02 +- 0.01 2 3

TIGR03844 (2/2) cysteate synthase
PF00296 (2/2) Luciferase-like monooxygenase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_29373 194.00 +- 64.00 2 0 0 0 0.01 +- 0.00 2 3

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07859 (2/2) alpha/beta hydrolase fold
PF00743 (2/2) Flavin-binding monooxygenase-like
precursor_jaccard_groups_9211 361.87 +- 329.39 4 0 0 0 0.09 +- 0.12 4 7

PF14759 (4/4) Reductase C-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF01047 (4/4) MarR family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_9210 595.72 +- 118.35 4 0 4 0 0.01 +- 0.02 4 9

TIGR01250 (4/4) proline-specific peptidase
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (4/4) Methylaspartate mutase E chain (MutE)
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (4/4) B12 binding domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00067 (4/4) Cytochrome P450
precursor_jaccard_groups_34338 585.00 +- 195.00 2 0 0 2 0.01 +- 0.01 2 7

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
precursor_jaccard_groups_38035 48.55 +- 5.83 2 0 0 0 0.06 +- 0.06 2 11

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17802 (2/2) Prealbumin-like fold domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF01555 (2/2) DNA methylase
precursor_jaccard_groups_18740 54.17 +- 15.06 3 0 0 0 0.17 +- 0.28 3 12

TIGR01581 (3/3) NifC-like ABC-type porter
TIGR00638 (3/3) molybdenum-pterin binding domain
PF12770 (3/3) CHAT domain
PF12728 (3/3) Helix-turn-helix domain
PF10590 (3/3) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF03459 (3/3) TOBE domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01494 (3/3) FAD binding domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_13157 40.07 +- 16.21 3 0 0 0 0.09 +- 0.07 3 6

PF09206 (3/3) Alpha-L-arabinofuranosidase B, catalytic
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF06283 (3/3) Trehalose utilisation
PF03422 (3/3) Carbohydrate binding module (family 6)
PF00801 (3/3) PKD domain
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_26946 268.75 +- 75.25 2 0 0 0 0.01 +- 0.01 2 5

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF01238 (2/2) Phosphomannose isomerase type I
PF00553 (2/2) Cellulose binding domain
PF00480 (2/2) ROK family
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_34217 334.62 +- 22.62 2 0 2 0 0.03 +- 0.01 2 6

PF13560 (2/2) Helix-turn-helix domain
PF13439 (2/2) Glycosyltransferase Family 4
PF00550 (2/2) Phosphopantetheine attachment site
PF00534 (2/2) Glycosyl transferases group 1
PF00501 (2/2) AMP-binding enzyme
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_13237 15.62 +- 1.14 4 0 0 0 0.19 +- 0.26 4 6

PF14200 (4/4) Ricin-type beta-trefoil lectin domain-like
PF12833 (4/4) Helix-turn-helix domain
PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF01965 (4/4) DJ-1/PfpI family
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
PF00583 (4/4) Acetyltransferase (GNAT) family
precursor_jaccard_groups_34856 218.90 +- 2.24 2 0 0 0 0.01 +- 0.01 2 4

PF06094 (2/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF05995 (2/2) Cysteine dioxygenase type I
PF05977 (2/2) Transmembrane secretion effector
PF00581 (2/2) Rhodanese-like domain
precursor_jaccard_groups_13234 609.89 +- 483.80 2 0 2 0 0.11 +- 0.30 2 17

TIGR03150 (2/2) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13452 (2/2) N-terminal half of MaoC dehydratase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01061 (2/2) ABC-2 type transporter
PF00856 (2/2) SET domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_16365 185.98 +- 50.28 3 0 0 0 0.09 +- 0.07 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF12902 (3/3) Ferritin-like
PF04616 (3/3) Glycosyl hydrolases family 43
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_40691 22.76 +- 0.00 2 0 0 0 0.09 +- 0.10 2 6

TIGR02608 (2/2) delta-60 repeat domain
TIGR01451 (2/2) conserved repeat domain
PF17164 (2/2) Domain of unknown function (DUF5122) beta-propeller
PF02811 (2/2) PHP domain
PF01345 (2/2) Domain of unknown function DUF11
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
precursor_jaccard_groups_23468 360.33 +- 159.67 2 0 0 0 0.01 +- 0.02 2 6

PF13560 (2/2) Helix-turn-helix domain
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF09851 (2/2) Short C-terminal domain
PF07731 (2/2) Multicopper oxidase
PF04972 (2/2) BON domain
PF00571 (2/2) CBS domain
precursor_jaccard_groups_37312 98.26 +- 57.40 2 0 0 0 0.10 +- 0.07 2 13

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
TIGR00055 (2/2) di-trans,poly-cis-decaprenylcistransferase
PF13202 (2/2) EF hand
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF13411 (1/2) MerR HTH family regulatory protein
PF01370 (1/2) NAD dependent epimerase/dehydratase family
precursor_jaccard_groups_3831 220.64 +- 131.76 10 0 0 0 0.02 +- 0.03 10 3

PF01145 (10/10) SPFH domain / Band 7 family
PF00877 (10/10) NlpC/P60 family
PF00196 (10/10) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_43636 197.79 +- 28.00 2 0 0 0 0.09 +- 0.23 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13621 (2/2) Cupin-like domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12704 (2/2) MacB-like periplasmic core domain
PF09334 (2/2) tRNA synthetases class I (M)
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02687 (2/2) FtsX-like permease family
PF01266 (2/2) FAD dependent oxidoreductase
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_31005 746.09 +- 12.83 2 0 0 0 0.02 +- 0.02 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain
precursor_jaccard_groups_23264 48.11 +- 10.37 3 0 0 0 0.15 +- 0.20 3 6

TIGR00996 (3/3) virulence factor Mce family protein
PF13406 (3/3) Transglycosylase SLT domain
PF11887 (3/3) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (3/3) MlaD protein
PF02405 (3/3) Permease MlaE
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_34039 57.63 +- 1.91 2 0 2 0 0.03 +- 0.03 2 2

PF13649 (2/2) Methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_40503 497.18 +- 7.60 2 0 0 0 0.06 +- 0.15 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF13473 (2/2) Cupredoxin-like domain
PF12698 (2/2) ABC-2 family transporter protein
PF11666 (2/2) Protein of unknown function (DUF2933)
PF07690 (2/2) Major Facilitator Superfamily
PF04945 (2/2) YHS domain
PF04191 (2/2) Phospholipid methyltransferase
PF04012 (2/2) PspA/IM30 family
PF03713 (2/2) Domain of unknown function (DUF305)
PF01435 (2/2) Peptidase family M48
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4915 126.89 +- 24.86 7 0 4 0 0.03 +- 0.02 7 6

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF07690 (7/7) Major Facilitator Superfamily
PF01238 (7/7) Phosphomannose isomerase type I
PF00282 (7/7) Pyridoxal-dependent decarboxylase conserved domain
PF07729 (4/7) FCD domain
PF00392 (4/7) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_41658 28.46 +- 0.27 2 0 0 0 0.25 +- 0.31 2 13

TIGR02133 (2/2) ribose 5-phosphate isomerase
TIGR00232 (2/2) transketolase
PF16896 (2/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (2/2) Major Facilitator Superfamily
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02734 (2/2) DAK2 domain
PF02733 (2/2) Dak1 domain
PF02502 (2/2) Ribose/Galactose Isomerase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00121 (2/2) Triosephosphate isomerase
precursor_jaccard_groups_3588 47.44 +- 20.03 10 0 0 0 0.17 +- 0.18 10 5

TIGR00996 (10/10) virulence factor Mce family protein
PF11887 (10/10) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (10/10) MlaD protein
PF02405 (10/10) Permease MlaE
PF00005 (10/10) ABC transporter
precursor_jaccard_groups_28159 86.33 +- 0.33 2 0 0 0 0.02 +- 0.02 2 2

PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_43985 260.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_28154 204.54 +- 182.46 2 0 2 0 0.07 +- 0.14 2 7

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_23865 370.50 +- 19.50 2 0 0 0 0.01 +- 0.00 2 6

PF13671 (2/2) AAA domain
PF13483 (2/2) Beta-lactamase superfamily domain
PF12697 (2/2) Alpha/beta hydrolase family
PF09037 (2/2) Stf0 sulphotransferase
PF07690 (2/2) Major Facilitator Superfamily
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_23864 410.42 +- 115.12 2 0 0 0 0.03 +- 0.04 2 16

TIGR00872 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14433 (2/2) SUKH-3 immunity protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13401 (2/2) AAA domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF06527 (2/2) TniQ
PF06414 (2/2) Zeta toxin
PF04199 (2/2) Putative cyclase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00665 (2/2) Integrase core domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_29057 218.13 +- 148.93 2 0 0 2 0.03 +- 0.07 2 15

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
PF18181 (2/2) SMODS and SLOG-associating 2TM effector domain 1
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13191 (2/2) AAA ATPase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00324 (2/2) Amino acid permease
PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF07729 (1/2) FCD domain
PF00754 (1/2) F5/8 type C domain
precursor_jaccard_groups_25606 81.28 +- 51.51 2 0 0 2 0.08 +- 0.10 2 10

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/2) Glutamine amidotransferase domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02195 (2/2) ParB-like nuclease domain
PF00733 (2/2) Asparagine synthase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_10572 1661.04 +- 262.74 4 0 2 4 0.01 +- 0.01 4 11

TIGR00702 (4/4) YcaO-type kinase domain
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF08007 (4/4) Cupin superfamily protein
PF07812 (4/4) TfuA-like protein
PF07690 (4/4) Major Facilitator Superfamily
PF05193 (4/4) Peptidase M16 inactive domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (4/4) Aminoglycoside 3-N-acetyltransferase
PF00675 (4/4) Insulinase (Peptidase family M16)
PF00326 (4/4) Prolyl oligopeptidase family
PF13349 (2/4) Putative adhesin
precursor_jaccard_groups_870 79.07 +- 52.58 32 0 0 0 0.09 +- 0.08 32 9

PF13581 (32/32) Histidine kinase-like ATPase domain
PF13492 (32/32) GAF domain
PF08447 (32/32) PAS fold
PF07228 (32/32) Stage II sporulation protein E (SpoIIE)
PF00149 (32/32) Calcineurin-like phosphoesterase
PF09348 (31/32) Domain of unknown function (DUF1990)
PF14158 (28/32) YndJ-like protein
PF11716 (28/32) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03446 (28/32) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_25609 216.00 +- 44.00 2 0 2 0 0.01 +- 0.00 2 5

TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_1890 664.02 +- 187.25 3 0 1 3 0.02 +- 0.02 3 8

TIGR04267 (3/3) HEXXH motif domain
TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF04055 (3/3) Radical SAM superfamily
PF02223 (3/3) Thymidylate kinase
PF00293 (3/3) NUDIX domain
PF00144 (3/3) Beta-lactamase
PF00069 (3/3) Protein kinase domain
PF00248 (2/3) Aldo/keto reductase family
precursor_jaccard_groups_24482 304.14 +- 106.31 2 0 2 0 0.02 +- 0.03 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF04820 (2/2) Tryptophan halogenase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_10611 186.91 +- 113.40 5 0 0 0 0.22 +- 0.23 5 13

TIGR03860 (5/5) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01728 (5/5) ABC transporter, substrate-binding protein, aliphatic sulfonates family
TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF09084 (5/5) NMT1/THI5 like
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
PF13410 (4/5) Glutathione S-transferase, C-terminal domain
PF08445 (4/5) FR47-like protein
TIGR03567 (3/5) FMN reductase
PF03358 (3/5) NADPH-dependent FMN reductase
precursor_jaccard_groups_10612 11.78 +- 2.49 3 0 0 0 0.17 +- 0.25 3 2

PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00553 (3/3) Cellulose binding domain
precursor_jaccard_groups_13523 460.22 +- 221.87 3 0 0 0 0.02 +- 0.01 3 8

PF14759 (3/3) Reductase C-terminal
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00866 (3/3) Ring hydroxylating beta subunit
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_31483 130.08 +- 54.20 2 0 0 0 0.02 +- 0.02 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09084 (2/2) NMT1/THI5 like
PF07555 (2/2) beta-N-acetylglucosaminidase
PF02838 (2/2) Glycosyl hydrolase family 20, domain 2
precursor_jaccard_groups_2184 104.27 +- 48.02 6 0 0 0 0.18 +- 0.31 6 25

TIGR03217 (6/6) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (6/6) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (6/6) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (6/6) 3-hydroxyanthranilate 3,4-dioxygenase
TIGR01814 (6/6) kynureninase
PF09290 (6/6) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08309 (6/6) LVIVD repeat
PF07836 (6/6) DmpG-like communication domain
PF06052 (6/6) 3-hydroxyanthranilic acid dioxygenase
PF04909 (6/6) Amidohydrolase
PF01590 (6/6) GAF domain
PF01557 (6/6) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (6/6) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (6/6) Endoribonuclease L-PSP
PF00682 (6/6) HMGL-like
PF00324 (6/6) Amino acid permease
PF00266 (6/6) Aminotransferase class-V
PF00171 (6/6) Aldehyde dehydrogenase family
PF07690 (4/6) Major Facilitator Superfamily
TIGR01728 (3/6) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF13649 (3/6) Methyltransferase domain
PF13379 (3/6) NMT1-like family
PF01903 (3/6) CbiX
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00005 (3/6) ABC transporter
precursor_jaccard_groups_35496 13.36 +- 0.00 2 0 0 0 0.22 +- 0.33 2 8

TIGR02412 (2/2) aminopeptidase N
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13384 (2/2) Homeodomain-like domain
PF11838 (2/2) ERAP1-like C-terminal domain
PF04402 (2/2) Protein of unknown function (DUF541)
PF01433 (2/2) Peptidase family M1 domain
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
precursor_jaccard_groups_31648 36.46 +- 1.28 2 0 0 0 0.08 +- 0.06 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01569 (2/2) PAP2 superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_14500 1035.36 +- 778.90 4 0 4 0 0.03 +- 0.13 4 18

TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/4) Thioesterase domain
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_42123 92.55 +- 24.72 2 0 2 0 0.05 +- 0.03 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08241 (2/2) Methyltransferase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_20185 106.95 +- 40.04 3 0 2 0 0.05 +- 0.08 3 8

PF12704 (3/3) MacB-like periplasmic core domain
PF02687 (3/3) FtsX-like permease family
PF02153 (3/3) Prephenate dehydrogenase
PF01471 (3/3) Putative peptidoglycan binding domain
PF00155 (3/3) Aminotransferase class I and II
PF00005 (3/3) ABC transporter
TIGR03618 (2/3) PPOX class probable F420-dependent enzyme
PF01243 (2/3) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_2188 130.38 +- 8.61 5 0 0 5 0.24 +- 0.08 5 34

TIGR03026 (5/5) nucleotide sugar dehydrogenase
TIGR01536 (5/5) asparagine synthase (glutamine-hydrolyzing)
PF16889 (5/5) Heparinase II/III N-terminus
PF16254 (5/5) Domain of unknown function (DUF4910)
PF16221 (5/5) winged helix-turn-helix
PF13857 (5/5) Ankyrin repeats (many copies)
PF13692 (5/5) Glycosyl transferases group 1
PF13579 (5/5) Glycosyl transferase 4-like domain
PF13537 (5/5) Glutamine amidotransferase domain
PF13489 (5/5) Methyltransferase domain
PF13439 (5/5) Glycosyltransferase Family 4
PF08484 (5/5) C-methyltransferase C-terminal domain
PF08421 (5/5) Putative zinc binding domain
PF07940 (5/5) Heparinase II/III-like protein
PF06628 (5/5) Catalase-related immune-responsive
PF04230 (5/5) Polysaccharide pyruvyl transferase
PF03721 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (5/5) Chain length determinant protein
PF02585 (5/5) GlcNAc-PI de-N-acetylase
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00984 (5/5) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00908 (5/5) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (5/5) Asparagine synthase
PF00535 (5/5) Glycosyl transferase family 2
PF00534 (5/5) Glycosyl transferases group 1
PF00202 (5/5) Aminotransferase class-III
PF00199 (5/5) Catalase
PF00107 (5/5) Zinc-binding dehydrogenase
PF13229 (4/5) Right handed beta helix region
TIGR03025 (3/5) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (3/5) CoA-binding domain
PF02397 (3/5) Bacterial sugar transferase
precursor_jaccard_groups_34140 259.00 +- 1.00 2 0 2 0 0.01 +- 0.00 2 3

PF16864 (2/2) Dimerisation domain
PF00891 (2/2) O-methyltransferase domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_332 18.91 +- 0.28 3 0 0 0 0.11 +- 0.10 3 2

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF05685 (3/3) Putative restriction endonuclease
precursor_jaccard_groups_33935 389.00 +- 131.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF08031 (2/2) Berberine and berberine like
PF07366 (2/2) SnoaL-like polyketide cyclase
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01565 (2/2) FAD binding domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_33933 50.74 +- 14.21 2 0 0 0 0.12 +- 0.12 2 6

PF08751 (2/2) TrwC relaxase
PF08007 (2/2) Cupin superfamily protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00248 (2/2) Aldo/keto reductase family
PF01545 (1/2) Cation efflux family
precursor_jaccard_groups_42236 61.54 +- 30.23 2 0 1 0 0.11 +- 0.20 2 14

TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13191 (2/2) AAA ATPase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00483 (2/2) Nucleotidyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_18423 1164.00 +- 4.24 3 0 3 0 0.01 +- 0.00 3 5

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_18420 309.60 +- 206.40 2 0 2 0 0.01 +- 0.01 2 2

PF07722 (2/2) Peptidase C26
PF02627 (2/2) Carboxymuconolactone decarboxylase family
precursor_jaccard_groups_18426 1206.67 +- 117.85 3 0 3 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF05114 (3/3) Protein of unknown function (DUF692)
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF06999 (2/3) Sucrase/ferredoxin-like
precursor_jaccard_groups_23597 2103.65 +- 1040.54 2 0 0 2 0.02 +- 0.05 2 23

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (2/2) Asparagine synthase
PF00550 (2/2) Phosphopantetheine attachment site
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00293 (2/2) NUDIX domain
PF00155 (2/2) Aminotransferase class I and II
PF13527 (1/2) Acetyltransferase (GNAT) domain
PF07690 (1/2) Major Facilitator Superfamily
PF04828 (1/2) Glutathione-dependent formaldehyde-activating enzyme
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_18424 88.83 +- 6.73 2 0 0 0 0.04 +- 0.05 2 2

PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_18429 84.43 +- 31.07 3 0 3 0 0.18 +- 0.11 3 16

TIGR01085 (3/3) UDP-N-acetylmuramyl-tripeptide synthetase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF08245 (3/3) Mur ligase middle domain
PF07690 (3/3) Major Facilitator Superfamily
PF02875 (3/3) Mur ligase family, glutamate ligase domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00005 (3/3) ABC transporter
PF00135 (2/3) Carboxylesterase family
precursor_jaccard_groups_16337 343.01 +- 173.37 3 0 3 0 0.07 +- 0.21 3 17

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13578 (3/3) Methyltransferase domain
PF13191 (3/3) AAA ATPase domain
PF05199 (3/3) GMC oxidoreductase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03704 (3/3) Bacterial transcriptional activator domain
PF01266 (3/3) FAD dependent oxidoreductase
PF01061 (3/3) ABC-2 type transporter
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00732 (3/3) GMC oxidoreductase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/3) Acyl transferase domain
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/3) ABC transporter
precursor_jaccard_groups_60 24.07 +- 34.18 7 0 1 0 0.21 +- 0.21 7 9

PF12728 (7/7) Helix-turn-helix domain
PF10935 (7/7) Protein of unknown function (DUF2637)
PF05122 (7/7) Mobile element transfer protein
PF01580 (7/7) FtsK/SpoIIIE family
PF00589 (7/7) Phage integrase family
TIGR01764 (5/7) DNA binding domain, excisionase family
TIGR00254 (4/7) diguanylate cyclase (GGDEF) domain
PF14659 (4/7) Phage integrase, N-terminal SAM-like domain
PF00990 (4/7) Diguanylate cyclase, GGDEF domain
precursor_jaccard_groups_5247 225.75 +- 32.25 2 0 2 2 0.01 +- 0.00 2 4

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_jaccard_groups_23049 10.59 +- 0.34 3 0 0 0 0.19 +- 0.09 3 5

TIGR02306 (3/3) RNA ligase
PF13602 (3/3) Zinc-binding dehydrogenase
PF09414 (3/3) RNA ligase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (2/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_5245 69.11 +- 50.89 2 0 2 0 0.13 +- 0.15 2 10

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00035 (2/2) aspartate racemase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF01177 (2/2) Asp/Glu/Hydantoin racemase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_883 58.48 +- 57.38 32 0 0 0 0.07 +- 0.07 32 3

PF12833 (32/32) Helix-turn-helix domain
PF02311 (32/32) AraC-like ligand binding domain
PF00150 (32/32) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_31262 61.70 +- 9.46 2 0 0 0 0.21 +- 0.27 2 13

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF14023 (2/2) Protein of unknown function (DUF4239)
PF14013 (2/2) MT0933-like antitoxin protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF13229 (2/2) Right handed beta helix region
PF04107 (2/2) Glutamate-cysteine ligase family 2(GCS2)
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00128 (2/2) Alpha amylase, catalytic domain
PF01872 (1/2) RibD C-terminal domain
precursor_jaccard_groups_23040 1293.33 +- 4.71 3 0 3 3 0.01 +- 0.00 3 6

PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF01928 (3/3) CYTH domain
PF01523 (3/3) Putative modulator of DNA gyrase
PF01061 (3/3) ABC-2 type transporter
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_888 474.42 +- 418.38 38 0 38 0 0.09 +- 0.14 38 23

PF13193 (38/38) AMP-binding enzyme C-terminal domain
PF10862 (38/38) FcoT-like thioesterase domain
PF07993 (38/38) Male sterility protein
PF07690 (38/38) Major Facilitator Superfamily
PF04314 (38/38) Copper chaperone PCu(A)C
PF02668 (38/38) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (38/38) Condensation domain
PF00550 (38/38) Phosphopantetheine attachment site
PF00501 (38/38) AMP-binding enzyme
TIGR01746 (37/38) thioester reductase domain
TIGR01733 (37/38) amino acid adenylation domain
TIGR01525 (37/38) heavy metal translocating P-type ATPase
PF05118 (37/38) Aspartyl/Asparaginyl beta-hydroxylase
PF00702 (37/38) haloacid dehalogenase-like hydrolase
PF00403 (37/38) Heavy-metal-associated domain
PF00122 (37/38) E1-E2 ATPase
PF01497 (35/38) Periplasmic binding protein
PF01032 (35/38) FecCD transport family
PF00005 (35/38) ABC transporter
PF08545 (34/38) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (34/38) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
TIGR00747 (33/38) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01965 (25/38) DJ-1/PfpI family
precursor_jaccard_groups_5080 107.82 +- 38.90 5 0 5 0 0.18 +- 0.14 5 12

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13672 (5/5) Protein phosphatase 2C
PF13411 (5/5) MerR HTH family regulatory protein
PF09335 (5/5) SNARE associated Golgi protein
PF07944 (5/5) Beta-L-arabinofuranosidase, GH127
PF07730 (5/5) Histidine kinase
PF05448 (5/5) Acetyl xylan esterase (AXE1)
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_42340 174.11 +- 32.29 2 0 0 2 0.02 +- 0.03 2 6

PF13023 (2/2) HD domain
PF12671 (2/2) Putative amidase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF01634 (2/2) ATP phosphoribosyltransferase
precursor_jaccard_groups_6911 47.03 +- 6.84 4 0 0 0 0.09 +- 0.13 4 9

PF13649 (4/4) Methyltransferase domain
PF13560 (4/4) Helix-turn-helix domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_32209 1258.84 +- 54.84 2 0 2 0 0.02 +- 0.05 2 9

TIGR00830 (2/2) PTS system, glucose subfamily, IIA component
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_42346 614.71 +- 165.29 2 0 0 0 0.03 +- 0.02 2 10

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_7758 141.10 +- 76.57 6 0 0 0 0.05 +- 0.04 6 8

PF14864 (6/6) Alkyl sulfatase C-terminal
PF14863 (6/6) Alkyl sulfatase dimerisation
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF00753 (6/6) Metallo-beta-lactamase superfamily
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_7759 240.82 +- 103.18 2 0 0 0 0.02 +- 0.02 2 11

TIGR00557 (2/2) 4-hydroxythreonine-4-phosphate dehydrogenase PdxA
PF17203 (2/2) Single cache domain 3
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13185 (2/2) GAF domain
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF07005 (2/2) Sugar-binding N-terminal domain
PF04166 (2/2) Pyridoxal phosphate biosynthetic protein PdxA
PF00455 (2/2) DeoR C terminal sensor domain
precursor_jaccard_groups_18197 20.73 +- 3.96 3 0 3 0 0.10 +- 0.10 3 4

PF13489 (3/3) Methyltransferase domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_14296 561.74 +- 523.38 2 0 2 0 0.11 +- 0.24 2 17

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08892 (2/2) YqcI/YcgG family
PF03621 (2/2) MbtH-like protein
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF01863 (1/2) Protein of unknown function DUF45
precursor_jaccard_groups_16503 164.79 +- 65.91 3 0 0 0 0.07 +- 0.04 3 5

TIGR01409 (3/3) Tat (twin-arginine translocation) pathway signal sequence
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF05426 (3/3) Alginate lyase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00295 (3/3) Glycosyl hydrolases family 28
precursor_jaccard_groups_39370 144.28 +- 34.15 2 0 0 0 0.07 +- 0.08 2 8

PF13377 (2/2) Periplasmic binding protein-like domain
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
precursor_jaccard_groups_10763 1128.80 +- 378.64 5 0 0 0 0.01 +- 0.00 5 9

PF14525 (5/5) AraC-binding-like domain
PF12833 (5/5) Helix-turn-helix domain
PF11716 (5/5) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03992 (5/5) Antibiotic biosynthesis monooxygenase
PF01613 (5/5) Flavin reductase like domain
PF00296 (5/5) Luciferase-like monooxygenase
PF12680 (4/5) SnoaL-like domain
PF02653 (4/5) Branched-chain amino acid transport system / permease component
PF00005 (4/5) ABC transporter
precursor_jaccard_groups_23289 1034.00 +- 514.00 2 0 2 0 0.01 +- 0.00 2 11

TIGR01751 (2/2) crotonyl-CoA carboxylase/reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF07730 (1/2) Histidine kinase
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_23288 30.51 +- 6.01 3 0 0 0 0.07 +- 0.04 3 2

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (3/3) Luciferase-like monooxygenase
precursor_jaccard_groups_36962 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF07538 (2/2) Clostridial hydrophobic W
PF07179 (2/2) SseB protein N-terminal domain
PF04198 (2/2) Putative sugar-binding domain
PF03692 (2/2) Putative zinc- or iron-chelating domain
precursor_jaccard_groups_13410 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_11623 96.51 +- 36.71 4 0 0 0 0.15 +- 0.14 4 15

TIGR01392 (4/4) homoserine O-acetyltransferase
TIGR01326 (4/4) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF18029 (4/4) Glyoxalase-like domain
PF08007 (4/4) Cupin superfamily protein
PF06999 (4/4) Sucrase/ferredoxin-like
PF03404 (4/4) Mo-co oxidoreductase dimerisation domain
PF01184 (4/4) GPR1/FUN34/yaaH family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00561 (4/4) alpha/beta hydrolase fold
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
TIGR01409 (3/4) Tat (twin-arginine translocation) pathway signal sequence
TIGR02980 (2/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04539 (2/4) Sigma-70 region 3
precursor_jaccard_groups_33240 133.23 +- 124.77 2 0 0 0 0.12 +- 0.16 2 6

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF07488 (2/2) Glycosyl hydrolase family 67 middle domain
PF07477 (2/2) Glycosyl hydrolase family 67 C-terminus
PF00754 (2/2) F5/8 type C domain
precursor_jaccard_groups_33793 183.95 +- 117.50 2 0 0 0 0.09 +- 0.21 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13515 (2/2) Fusaric acid resistance protein-like
PF13454 (2/2) FAD-NAD(P)-binding
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00206 (2/2) Lyase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_33790 20.00 +- 0.00 2 0 0 0 0.20 +- 0.13 2 9

PF17964 (2/2) Bacterial Ig domain
PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01614 (2/2) Bacterial transcriptional regulator
PF00722 (2/2) Glycosyl hydrolases family 16
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_35811 170.05 +- 87.95 2 0 0 0 0.02 +- 0.03 2 4

PF12833 (2/2) Helix-turn-helix domain
PF02311 (2/2) AraC-like ligand binding domain
PF00775 (2/2) Dioxygenase
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_35810 388.50 +- 1.50 2 0 0 2 0.01 +- 0.00 2 3

PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01266 (2/2) FAD dependent oxidoreductase
PF00881 (2/2) Nitroreductase family
precursor_jaccard_groups_3779 91.72 +- 117.35 10 0 10 0 0.10 +- 0.21 10 14

TIGR01746 (10/10) thioester reductase domain
TIGR01733 (10/10) amino acid adenylation domain
TIGR01720 (10/10) non-ribosomal peptide synthase domain TIGR01720
PF14433 (10/10) SUKH-3 immunity protein
PF13302 (10/10) Acetyltransferase (GNAT) domain
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF09339 (10/10) IclR helix-turn-helix domain
PF07993 (10/10) Male sterility protein
PF05448 (10/10) Acetyl xylan esterase (AXE1)
PF01614 (10/10) Bacterial transcriptional regulator
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF03621 (6/10) MbtH-like protein
precursor_jaccard_groups_9226 376.50 +- 233.17 4 0 4 0 0.03 +- 0.04 4 5

TIGR01188 (4/4) daunorubicin resistance ABC transporter, ATP-binding protein
PF01757 (4/4) Acyltransferase family
PF01061 (4/4) ABC-2 type transporter
PF00067 (4/4) Cytochrome P450
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_4444 104.65 +- 49.74 9 0 9 0 0.06 +- 0.04 9 11

TIGR01733 (9/9) amino acid adenylation domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00698 (9/9) Acyl transferase domain
PF00668 (9/9) Condensation domain
PF00551 (9/9) Formyl transferase
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain
PF00067 (9/9) Cytochrome P450
precursor_jaccard_groups_18997 141.16 +- 40.59 3 0 0 0 0.03 +- 0.01 3 8

PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_18771 148.89 +- 70.74 3 0 3 0 0.07 +- 0.10 3 17

TIGR03217 (3/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (3/3) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (3/3) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (3/3) 3-hydroxyanthranilate 3,4-dioxygenase
TIGR01814 (3/3) kynureninase
PF09290 (3/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08309 (3/3) LVIVD repeat
PF07836 (3/3) DmpG-like communication domain
PF06052 (3/3) 3-hydroxyanthranilic acid dioxygenase
PF04909 (3/3) Amidohydrolase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (3/3) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (3/3) Endoribonuclease L-PSP
PF00682 (3/3) HMGL-like
PF00324 (3/3) Amino acid permease
PF00266 (3/3) Aminotransferase class-V
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_4440 21.62 +- 13.90 4 0 0 0 0.14 +- 0.14 4 3

TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF13302 (3/4) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_14477 428.74 +- 208.93 4 0 0 0 0.02 +- 0.02 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02615 (4/4) Malate/L-lactate dehydrogenase
PF00753 (4/4) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_19771 21.09 +- 7.73 2 0 0 0 0.17 +- 0.27 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13520 (2/2) Amino acid permease
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01590 (2/2) GAF domain
PF00989 (2/2) PAS fold
PF00741 (2/2) Gas vesicle protein
PF00083 (2/2) Sugar (and other) transporter
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_2988 95.83 +- 26.45 5 0 0 0 0.02 +- 0.02 5 5

PF13649 (5/5) Methyltransferase domain
PF07504 (5/5) Fungalysin/Thermolysin Propeptide Motif
PF02868 (5/5) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (5/5) Proprotein convertase P-domain
PF01447 (5/5) Thermolysin metallopeptidase, catalytic domain
precursor_jaccard_groups_41823 41.81 +- 4.50 2 0 0 0 0.17 +- 0.18 2 7

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07398 (2/2) MDMPI C-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_19779 47.40 +- 14.45 2 0 0 0 0.12 +- 0.27 2 6

TIGR01179 (2/2) UDP-glucose 4-epimerase GalE
PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00535 (2/2) Glycosyl transferase family 2
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_41539 181.48 +- 56.68 2 0 0 0 0.02 +- 0.03 2 5

PF13458 (2/2) Periplasmic binding protein
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_2987 56.36 +- 0.21 3 0 0 0 0.25 +- 0.34 3 9

TIGR00879 (3/3) MFS transporter, sugar porter (SP) family
TIGR00745 (3/3) 2-dehydropantoate 2-reductase
PF08546 (3/3) Ketopantoate reductase PanE/ApbA C terminal
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF02558 (3/3) Ketopantoate reductase PanE/ApbA
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00083 (3/3) Sugar (and other) transporter
precursor_jaccard_groups_21971 84.88 +- 11.43 3 0 0 0 0.10 +- 0.07 3 8

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13564 (3/3) DoxX-like family
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_27346 49.54 +- 0.78 2 0 2 0 0.12 +- 0.29 2 9

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_27342 371.43 +- 148.57 2 0 0 0 0.02 +- 0.03 2 8

TIGR03168 (2/2) hexose kinase, 1-phosphofructokinase family
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00167 (1/2) ketose-bisphosphate aldolase
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
precursor_jaccard_groups_3250 71.91 +- 29.46 9 0 9 0 0.03 +- 0.03 9 3

TIGR03083 (9/9) uncharacterized Actinobacterial protein TIGR03083
PF11716 (9/9) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02627 (9/9) Carboxymuconolactone decarboxylase family
precursor_jaccard_groups_27897 184.29 +- 73.71 2 0 0 0 0.01 +- 0.01 2 3

TIGR03168 (2/2) hexose kinase, 1-phosphofructokinase family
PF11964 (2/2) SpoIIAA-like
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_15016 160.83 +- 36.88 4 0 3 0 0.04 +- 0.10 4 8

TIGR01821 (4/4) 5-aminolevulinic acid synthase
PF16884 (4/4) N-terminal domain of oxidoreductase
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (4/4) Major Facilitator Superfamily
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (4/4) Aminotransferase class I and II
PF00107 (4/4) Zinc-binding dehydrogenase
precursor_jaccard_groups_45023 206.40 +- 51.60 2 0 0 0 0.02 +- 0.02 2 3

PF09594 (2/2) Glycosyltransferase family 87
PF06224 (2/2) Winged helix DNA-binding domain
PF00534 (2/2) Glycosyl transferases group 1
precursor_jaccard_groups_37762 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_1357 75.01 +- 63.38 25 0 7 25 0.12 +- 0.17 25 5

TIGR03882 (25/25) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (25/25) thiazole/oxazole-forming peptide maturase, SagD family component
PF03704 (25/25) Bacterial transcriptional activator domain
PF02624 (25/25) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (25/25) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_8483 45.78 +- 8.17 3 0 0 0 0.04 +- 0.01 3 2

PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_36149 281.67 +- 108.33 2 0 1 0 0.01 +- 0.01 2 6

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
PF13535 (2/2) ATP-grasp domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
precursor_jaccard_groups_37764 85.00 +- 18.83 2 0 0 0 0.14 +- 0.13 2 10

PF13646 (2/2) HEAT repeats
PF12838 (2/2) 4Fe-4S dicluster domain
PF09084 (2/2) NMT1/THI5 like
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02910 (2/2) Fumarate reductase flavoprotein C-term
PF00890 (2/2) FAD binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_37769 506.10 +- 273.90 2 0 0 0 0.01 +- 0.00 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
PF12146 (1/2) Serine aminopeptidase, S33
PF00561 (1/2) alpha/beta hydrolase fold
precursor_jaccard_groups_27906 149.12 +- 39.59 2 0 0 0 0.06 +- 0.02 2 7

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_24628 38.17 +- 3.77 2 0 0 0 0.11 +- 0.09 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_6403 276.90 +- 288.01 7 0 0 0 0.04 +- 0.05 7 5

TIGR03930 (7/7) WXG100 family type VII secretion target
TIGR03921 (7/7) type VII secretion-associated serine protease mycosin
PF06013 (7/7) Proteins of 100 residues with WXG
PF00082 (7/7) Subtilase family
PF05108 (5/7) Type VII secretion system ESX-1, transport TM domain B
precursor_jaccard_groups_41642 459.60 +- 159.60 2 0 2 0 0.02 +- 0.01 2 18

TIGR02814 (2/2) PfaD family protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF07977 (2/2) FabA-like domain
PF03060 (2/2) Nitronate monooxygenase
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR02813 (1/2) polyketide-type polyunsaturated fatty acid synthase PfaA
PF18328 (1/2) Fatty acid synthase subunit PfaD N-terminal domain
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00698 (1/2) Acyl transferase domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_1997 33.64 +- 11.94 13 0 0 0 0.07 +- 0.09 13 5

PF17866 (13/13) AAA lid domain
PF13229 (13/13) Right handed beta helix region
PF00652 (13/13) Ricin-type beta-trefoil lectin domain
PF00082 (13/13) Subtilase family
PF00004 (13/13) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_10145 140.30 +- 117.70 2 0 0 0 0.05 +- 0.07 2 2

PF10056 (2/2) Uncharacterized conserved protein (DUF2293)
PF08592 (2/2) Domain of unknown function (DUF1772)
precursor_jaccard_groups_26509 115.93 +- 84.07 2 0 0 0 0.07 +- 0.17 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF01227 (2/2) GTP cyclohydrolase I
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_24617 949.55 +- 480.45 2 0 0 0 0.01 +- 0.00 2 11

TIGR01141 (2/2) histidinol-phosphate transaminase
TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00155 (2/2) Aminotransferase class I and II
PF00005 (2/2) ABC transporter
PF07690 (1/2) Major Facilitator Superfamily
precursor_jaccard_groups_29471 258.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 3

PF13649 (2/2) Methyltransferase domain
PF13460 (2/2) NAD(P)H-binding
PF01494 (2/2) FAD binding domain
precursor_jaccard_groups_14871 50.58 +- 19.79 4 0 4 0 0.15 +- 0.30 4 9

TIGR02406 (4/4) diaminobutyrate acetyltransferase
TIGR00556 (4/4) phosphopantetheine--protein transferase domain
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF06339 (4/4) Ectoine synthase
PF02784 (4/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
precursor_jaccard_groups_20950 127.43 +- 19.00 3 0 0 3 0.13 +- 0.18 3 9

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF13443 (3/3) Cro/C1-type HTH DNA-binding domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11188 (3/3) Protein of unknown function (DUF2975)
PF01494 (3/3) FAD binding domain
PF00881 (3/3) Nitroreductase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_5060 96.06 +- 65.98 8 0 0 0 0.03 +- 0.03 8 3

PF01068 (8/8) ATP dependent DNA ligase domain
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00106 (8/8) short chain dehydrogenase
precursor_jaccard_groups_41790 133.48 +- 31.64 2 0 0 0 0.04 +- 0.04 2 6

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_7934 556.36 +- 312.83 6 0 0 0 0.03 +- 0.10 6 7

PF13185 (6/6) GAF domain
PF12833 (6/6) Helix-turn-helix domain
PF09056 (6/6) Prokaryotic phospholipase A2
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF01965 (6/6) DJ-1/PfpI family
PF01483 (6/6) Proprotein convertase P-domain
PF00082 (6/6) Subtilase family
precursor_jaccard_groups_8797 89.96 +- 17.78 3 0 0 0 0.03 +- 0.02 3 3

TIGR01428 (3/3) haloacid dehalogenase, type II
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF01266 (3/3) FAD dependent oxidoreductase
precursor_jaccard_groups_41000 26.09 +- 2.18 2 0 0 0 0.15 +- 0.26 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00149 (2/2) Calcineurin-like phosphoesterase
PF00135 (2/2) Carboxylesterase family
precursor_jaccard_groups_4937 53.21 +- 18.99 8 0 0 0 0.15 +- 0.26 8 8

PF12840 (8/8) Helix-turn-helix domain
PF09594 (8/8) Glycosyltransferase family 87
PF03088 (8/8) Strictosidine synthase
PF07745 (7/8) Glycosyl hydrolase family 53
TIGR00494 (5/8) protein CrcB
PF02537 (5/8) CrcB-like protein, Camphor Resistance (CrcB)
TIGR03814 (4/8) glutaminase A
PF04960 (4/8) Glutaminase
precursor_jaccard_groups_15706 2433.09 +- 685.07 3 0 3 3 0.01 +- 0.01 3 14

TIGR01733 (3/3) amino acid adenylation domain
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
PF18130 (3/3) ATP-grasp N-terminal domain
PF13537 (3/3) Glutamine amidotransferase domain
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF03547 (3/3) Membrane transport protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01063 (3/3) Amino-transferase class IV
PF00733 (3/3) Asparagine synthase
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00144 (3/3) Beta-lactamase
precursor_jaccard_groups_33336 636.10 +- 403.90 2 0 0 0 0.01 +- 0.00 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
TIGR03919 (1/2) type VII secretion protein EccB
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
precursor_jaccard_groups_26728 579.66 +- 12.06 2 0 0 0 0.02 +- 0.03 2 8

TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF08007 (2/2) Cupin superfamily protein
PF07371 (2/2) Protein of unknown function (DUF1490)
PF01297 (2/2) Zinc-uptake complex component A periplasmic
PF00950 (2/2) ABC 3 transport family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_39812 35.34 +- 0.78 2 0 2 0 0.08 +- 0.10 2 4

PF13712 (2/2) Glycosyltransferase like family
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00483 (2/2) Nucleotidyl transferase
precursor_jaccard_groups_30838 228.36 +- 13.36 2 0 2 0 0.17 +- 0.30 2 24

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF18369 (1/2) Polyketide synthase dimerisation element domain
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13191 (1/2) AAA ATPase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_16116 33.79 +- 9.21 2 0 0 0 0.06 +- 0.02 2 2

PF13649 (2/2) Methyltransferase domain
PF11139 (2/2) Sap, sulfolipid-1-addressing protein
precursor_jaccard_groups_31351 430.00 +- 215.00 2 0 2 0 0.02 +- 0.01 2 16

TIGR01426 (2/2) glycosyltransferase, MGT family
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13489 (2/2) Methyltransferase domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08659 (2/2) KR domain
PF05345 (2/2) Putative Ig domain
PF04185 (2/2) Phosphoesterase family
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_41384 307.65 +- 79.35 2 0 0 0 0.06 +- 0.06 2 9

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14494 (2/2) Domain of unknown function (DUF4436)
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13581 (2/2) Histidine kinase-like ATPase domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04371 (2/2) Porphyromonas-type peptidyl-arginine deiminase
PF01590 (2/2) GAF domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_1194 35.19 +- 33.50 13 0 0 0 0.16 +- 0.15 13 4

PF03067 (13/13) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (13/13) SPFH domain / Band 7 family
PF13193 (11/13) AMP-binding enzyme C-terminal domain
PF00501 (11/13) AMP-binding enzyme
precursor_jaccard_groups_44012 49.83 +- 15.17 2 0 0 0 0.04 +- 0.05 2 8

PF13481 (2/2) AAA domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF07508 (2/2) Recombinase
PF05713 (2/2) Bacterial mobilisation protein (MobC)
PF03432 (2/2) Relaxase/Mobilisation nuclease domain
PF00772 (2/2) DnaB-like helicase N terminal domain
PF00239 (2/2) Resolvase, N terminal domain
precursor_jaccard_groups_26433 52.42 +- 4.72 2 0 0 0 0.10 +- 0.15 2 11

TIGR03025 (2/2) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (2/2) CoA-binding domain
PF13692 (2/2) Glycosyl transferases group 1
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13439 (2/2) Glycosyltransferase Family 4
PF04932 (2/2) O-Antigen ligase
PF03023 (2/2) Lipid II flippase MurJ
PF02706 (2/2) Chain length determinant protein
PF02397 (2/2) Bacterial sugar transferase
PF01522 (2/2) Polysaccharide deacetylase
PF00534 (2/2) Glycosyl transferases group 1
precursor_jaccard_groups_27120 334.90 +- 12.40 2 0 0 0 0.01 +- 0.02 2 15

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01241 (2/2) ATP-dependent metallopeptidase HflB
TIGR00374 (2/2) TIGR00374 family protein
PF17862 (2/2) AAA+ lid domain
PF13649 (2/2) Methyltransferase domain
PF13473 (2/2) Cupredoxin-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF06480 (2/2) FtsH Extracellular
PF04945 (2/2) YHS domain
PF03706 (2/2) Lysylphosphatidylglycerol synthase TM region
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01434 (2/2) Peptidase family M41
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00122 (2/2) E1-E2 ATPase
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_26438 520.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF16916 (2/2) Dimerisation domain of Zinc Transporter
PF07729 (2/2) FCD domain
PF01545 (2/2) Cation efflux family
PF01266 (2/2) FAD dependent oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_11383 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
precursor_jaccard_groups_26078 627.35 +- 64.02 2 0 0 2 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
precursor_jaccard_groups_29610 27.93 +- 1.01 2 0 0 0 0.22 +- 0.23 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_15495 97.17 +- 33.77 3 0 3 0 0.05 +- 0.06 3 10

TIGR01733 (3/3) amino acid adenylation domain
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF14681 (3/3) Uracil phosphoribosyltransferase
PF14027 (3/3) Questin oxidase-like
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF04227 (3/3) Indigoidine synthase A like protein
PF00975 (3/3) Thioesterase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_41732 72.37 +- 12.06 2 0 0 0 0.06 +- 0.01 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13535 (2/2) ATP-grasp domain
PF13394 (2/2) 4Fe-4S single cluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF06508 (2/2) Queuosine biosynthesis protein QueC
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00355 (2/2) Rieske [2Fe-2S] domain
precursor_jaccard_groups_29968 274.58 +- 189.71 2 0 2 0 0.03 +- 0.05 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_16606 163.06 +- 52.11 3 0 0 0 0.13 +- 0.21 3 17

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF13796 (3/3) Putative sensor
PF12730 (3/3) ABC-2 family transporter protein
PF07730 (3/3) Histidine kinase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04444 (3/3) Catechol dioxygenase N terminus
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF02585 (3/3) GlcNAc-PI de-N-acetylase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00775 (3/3) Dioxygenase
PF00465 (3/3) Iron-containing alcohol dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_19959 130.81 +- 22.43 3 0 0 0 0.07 +- 0.04 3 5

PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_30236 43.15 +- 12.56 2 0 0 0 0.05 +- 0.04 2 2

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_21190 56.90 +- 12.37 3 0 0 0 0.17 +- 0.19 3 9

PF16262 (3/3) Domain of unknown function (DUF4916)
PF14230 (3/3) Domain of unknown function (DUF4333)
PF04909 (3/3) Amidohydrolase
PF04672 (3/3) S-adenosyl methyltransferase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00120 (3/3) Glutamine synthetase, catalytic domain
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
PF01494 (2/3) FAD binding domain
precursor_jaccard_groups_5475 64.26 +- 49.54 8 0 0 0 0.09 +- 0.11 8 8

TIGR04350 (8/8) putative C-S lyase
PF18105 (8/8) PGM1 C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF00291 (8/8) Pyridoxal-phosphate dependent enzyme
PF00155 (8/8) Aminotransferase class I and II
PF14100 (5/8) Methane oxygenase PmoA
PF02894 (5/8) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/8) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_19953 209.81 +- 69.57 3 0 0 0 0.02 +- 0.03 3 4

TIGR01926 (3/3) uncharacterized peroxidase-related enzyme
PF08028 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
precursor_jaccard_groups_6992 24.23 +- 0.11 2 0 0 0 0.25 +- 0.29 2 15

PF17871 (2/2) AAA lid domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (2/2) FCD domain
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF05544 (2/2) Proline racemase
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03711 (2/2) Orn/Lys/Arg decarboxylase, C-terminal domain
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF01276 (2/2) Orn/Lys/Arg decarboxylase, major domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_17884 30.43 +- 1.57 2 0 2 0 0.13 +- 0.13 2 7

PF11991 (2/2) Tryptophan dimethylallyltransferase
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (2/2) Beta-eliminating lyase
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_20779 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF17912 (2/2) MalK OB fold domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12899 (2/2) Alkaline and neutral invertase
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26651 142.34 +- 115.66 2 0 2 0 0.04 +- 0.05 2 2

PF11806 (2/2) Domain of unknown function (DUF3327)
PF00756 (2/2) Putative esterase
precursor_jaccard_groups_17882 404.62 +- 121.82 3 0 0 0 0.05 +- 0.02 3 13

PF16353 (3/3) Domain of unknown function(DUF4981)
PF07748 (3/3) Glycosyl hydrolases family 38 C-terminal domain
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01381 (3/3) Helix-turn-helix
PF01212 (3/3) Beta-eliminating lyase
PF01074 (3/3) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF04341 (2/3) Protein of unknown function, DUF485
PF00474 (2/3) Sodium:solute symporter family
precursor_jaccard_groups_29763 117.68 +- 11.32 2 0 0 0 0.03 +- 0.00 2 7

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF14310 (2/2) Fibronectin type III-like domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_531 190.70 +- 92.05 56 0 54 56 0.14 +- 0.11 56 12

TIGR03882 (56/56) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (56/56) thiazole/oxazole-forming peptide maturase, SagD family component
PF13191 (56/56) AAA ATPase domain
PF03704 (56/56) Bacterial transcriptional activator domain
PF02624 (56/56) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (56/56) Transcriptional regulatory protein, C terminal
TIGR03605 (55/56) SagB-type dehydrogenase domain
PF00881 (54/56) Nitroreductase family
PF14028 (53/56) Lantibiotic biosynthesis dehydratase C-term
PF04738 (53/56) Lantibiotic dehydratase, N terminus
PF00005 (53/56) ABC transporter
PF01061 (52/56) ABC-2 type transporter
precursor_jaccard_groups_26233 117.00 +- 13.00 2 0 2 0 0.02 +- 0.01 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_45300 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_37903 525.27 +- 248.73 2 0 0 0 0.02 +- 0.07 2 7

PF08241 (2/2) Methyltransferase domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF13359 (1/2) DDE superfamily endonuclease
PF02585 (1/2) GlcNAc-PI de-N-acetylase
precursor_jaccard_groups_8469 117.23 +- 36.01 6 0 1 0 0.12 +- 0.26 6 14

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF04075 (6/6) F420H(2)-dependent quinone reductase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF01047 (6/6) MarR family
PF00999 (6/6) Sodium/hydrogen exchanger family
PF01613 (5/6) Flavin reductase like domain
PF01494 (5/6) FAD binding domain
PF00289 (4/6) Biotin carboxylase, N-terminal domain
PF02786 (3/6) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_jaccard_groups_22806 246.26 +- 120.66 3 0 0 0 0.14 +- 0.13 3 21

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF04909 (3/3) Amidohydrolase
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00248 (3/3) Aldo/keto reductase family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
PF09084 (2/3) NMT1/THI5 like
PF05025 (2/3) RbsD / FucU transport protein family
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00175 (2/3) Oxidoreductase NAD-binding domain
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_4132 44.27 +- 2.44 6 0 0 0 0.21 +- 0.35 6 10

TIGR03177 (6/6) Flp pilus assembly protein CpaB
PF16976 (6/6) Flp pilus assembly protein RcpC/CpaB
PF13614 (6/6) AAA domain
PF07811 (6/6) TadE-like protein
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF00072 (6/6) Response regulator receiver domain
PF13400 (4/6) Putative Flp pilus-assembly TadE/G-like
PF00691 (4/6) OmpA family
precursor_jaccard_groups_4136 141.74 +- 88.63 6 0 0 0 0.04 +- 0.09 6 3

PF06441 (6/6) Epoxide hydrolase N terminus
PF00561 (6/6) alpha/beta hydrolase fold
PF00583 (5/6) Acetyltransferase (GNAT) family
precursor_jaccard_groups_38339 200.98 +- 25.48 2 0 0 0 0.06 +- 0.03 2 8

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05336 (2/2) L-rhamnose mutarotase
PF04909 (2/2) Amidohydrolase
PF03466 (2/2) LysR substrate binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00722 (2/2) Glycosyl hydrolases family 16
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_10967 72.62 +- 26.87 4 0 0 0 0.10 +- 0.16 4 8

TIGR00350 (4/4) cell envelope-related function transcriptional attenuator common domain
PF13399 (4/4) LytR cell envelope-related transcriptional attenuator
PF07859 (4/4) alpha/beta hydrolase fold
PF03816 (4/4) Cell envelope-related transcriptional attenuator domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01258 (4/4) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00459 (4/4) Inositol monophosphatase family
precursor_jaccard_groups_1645 300.79 +- 179.55 15 0 3 0 0.04 +- 0.12 15 4

PF00717 (15/15) Peptidase S24-like
PF00005 (15/15) ABC transporter
PF07291 (13/15) Methylamine utilisation protein MauE
PF00578 (11/15) AhpC/TSA family
precursor_jaccard_groups_4058 236.73 +- 79.23 5 0 0 0 0.08 +- 0.16 5 16

PF13649 (5/5) Methyltransferase domain
PF13394 (5/5) 4Fe-4S single cluster domain
PF10977 (5/5) Protein of unknown function (DUF2797)
PF05331 (5/5) Protein of unknown function (DUF742)
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02223 (5/5) Thymidylate kinase
PF01590 (5/5) GAF domain
PF01242 (5/5) 6-pyruvoyl tetrahydropterin synthase
PF01227 (5/5) GTP cyclohydrolase I
PF00723 (5/5) Glycosyl hydrolases family 15
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (5/5) NUDIX domain
precursor_jaccard_groups_10963 22.72 +- 3.64 3 0 0 0 0.09 +- 0.08 3 4

PF12840 (3/3) Helix-turn-helix domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF04616 (3/3) Glycosyl hydrolases family 43
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_17640 977.21 +- 452.79 2 0 2 2 0.01 +- 0.02 2 25

TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (2/2) mycofactocin precursor
TIGR03967 (2/2) putative mycofactocin binding protein MftB
TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (2/2) mycofactocin system glycosyltransferase
TIGR03964 (2/2) mycofactocin system creatininase family protein
TIGR03962 (2/2) mycofactocin radical SAM maturase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF08242 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF03129 (2/2) Anticodon binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF01070 (2/2) FMN-dependent dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00535 (2/2) Glycosyl transferase family 2
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_30659 212.87 +- 45.13 2 0 0 0 0.02 +- 0.03 2 11

TIGR00773 (2/2) Na+/H+ antiporter NhaA
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13462 (2/2) Thioredoxin
PF12831 (2/2) FAD dependent oxidoreductase
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF06965 (2/2) Na+/H+ antiporter 1
PF02515 (2/2) CoA-transferase family III
PF01381 (2/2) Helix-turn-helix
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_25296 38.07 +- 21.47 2 0 0 0 0.08 +- 0.08 2 2

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_38332 129.59 +- 3.20 2 0 2 0 0.04 +- 0.04 2 17

TIGR01426 (2/2) glycosyltransferase, MGT family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13560 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08659 (2/2) KR domain
PF03060 (2/2) Nitronate monooxygenase
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4050 29.70 +- 3.24 10 0 10 0 0.15 +- 0.15 10 7

PF13620 (10/10) Carboxypeptidase regulatory-like domain
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF11512 (10/10) Agrobacterium tumefaciens protein Atu4866
PF04264 (10/10) YceI-like domain
PF00005 (10/10) ABC transporter
PF04978 (9/10) Protein of unknown function (DUF664)
PF02585 (5/10) GlcNAc-PI de-N-acetylase
precursor_jaccard_groups_15805 193.50 +- 64.50 2 0 2 0 0.01 +- 0.01 2 2

PF07993 (2/2) Male sterility protein
PF00202 (2/2) Aminotransferase class-III
precursor_jaccard_groups_20179 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_jaccard_groups_5985 68.67 +- 12.26 3 0 0 0 0.04 +- 0.05 3 7

PF14435 (3/3) SUKH-4 immunity protein
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_17081 15.79 +- 2.01 3 0 0 0 0.19 +- 0.22 3 3

PF13302 (3/3) Acetyltransferase (GNAT) domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00348 (3/3) Polyprenyl synthetase
precursor_jaccard_groups_240 20.77 +- 15.68 104 0 10 0 0.13 +- 0.12 104 5

PF04066 (104/104) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (104/104) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (104/104) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (104/104) Proton-conducting membrane transporter
PF13244 (103/104) Domain of unknown function (DUF4040)
precursor_jaccard_groups_10217 36.77 +- 3.68 2 0 0 0 0.19 +- 0.17 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_13093 16.83 +- 0.00 2 0 2 0 0.18 +- 0.22 2 5

TIGR00738 (2/2) Rrf2 family protein
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF05532 (2/2) CsbD-like
PF02082 (2/2) Transcriptional regulator
PF01979 (2/2) Amidohydrolase family
precursor_jaccard_groups_45496 146.83 +- 113.17 2 0 0 0 0.03 +- 0.06 2 2

PF01872 (2/2) RibD C-terminal domain
PF01738 (2/2) Dienelactone hydrolase family
precursor_jaccard_groups_18179 50.96 +- 24.18 3 0 0 0 0.05 +- 0.03 3 3

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_38903 28.81 +- 8.01 2 0 0 0 0.15 +- 0.26 2 6

PF09981 (2/2) Uncharacterized protein conserved in bacteria (DUF2218)
PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_5504 15.48 +- 0.66 5 0 0 0 0.19 +- 0.21 5 4

PF13722 (5/5) 5TM C-terminal transporter carbon starvation CstA
PF04328 (5/5) Selenoprotein, putative
PF02554 (5/5) Carbon starvation protein CstA
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_jaccard_groups_5509 72.06 +- 53.82 5 0 0 0 0.14 +- 0.26 5 8

PF11758 (5/5) Aureocin-like type II bacteriocin
PF03372 (5/5) Endonuclease/Exonuclease/phosphatase family
PF02518 (5/5) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase
PF00672 (5/5) HAMP domain
PF00512 (5/5) His Kinase A (phospho-acceptor) domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00072 (5/5) Response regulator receiver domain
precursor_jaccard_groups_669 203.27 +- 123.99 15 0 1 0 0.04 +- 0.12 15 3

PF13193 (15/15) AMP-binding enzyme C-terminal domain
PF01039 (15/15) Carboxyl transferase domain
PF00501 (15/15) AMP-binding enzyme
precursor_jaccard_groups_17466 22.78 +- 1.41 2 0 2 0 0.20 +- 0.14 2 12

TIGR00561 (2/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF12769 (2/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02233 (2/2) NAD(P) transhydrogenase beta subunit
PF01262 (2/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_20216 217.51 +- 111.53 3 0 3 0 0.08 +- 0.21 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_660 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like
precursor_jaccard_groups_20008 84.76 +- 7.49 3 0 0 0 0.14 +- 0.19 3 12

TIGR01187 (3/3) polyamine ABC transporter, ATP-binding protein
TIGR00212 (3/3) hydroxymethylbilane synthase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF03900 (3/3) Porphobilinogen deaminase, C-terminal domain
PF01593 (3/3) Flavin containing amine oxidoreductase
PF01379 (3/3) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_24817 15.80 +- 3.70 2 0 0 0 0.21 +- 0.21 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04341 (2/2) Protein of unknown function, DUF485
PF04029 (2/2) 2-phosphosulpholactate phosphatase
PF00474 (2/2) Sodium:solute symporter family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF18029 (1/2) Glyoxalase-like domain
precursor_jaccard_groups_24816 37.39 +- 1.33 2 0 2 0 0.24 +- 0.41 2 13

TIGR01051 (2/2) DNA topoisomerase I
PF13368 (2/2) Topoisomerase C-terminal repeat
PF07730 (2/2) Histidine kinase
PF01751 (2/2) Toprim domain
PF01131 (2/2) DNA topoisomerase
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
TIGR00678 (1/2) DNA polymerase III, delta' subunit
TIGR00041 (1/2) dTMP kinase
PF13177 (1/2) DNA polymerase III, delta subunit
PF05175 (1/2) Methyltransferase small domain
PF02223 (1/2) Thymidylate kinase
precursor_jaccard_groups_24819 35.97 +- 0.14 2 0 0 0 0.08 +- 0.04 2 5

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
precursor_jaccard_groups_5726 485.44 +- 338.34 8 0 0 0 0.04 +- 0.08 8 6

TIGR03930 (8/8) WXG100 family type VII secretion target
PF06013 (8/8) Proteins of 100 residues with WXG
PF05108 (8/8) Type VII secretion system ESX-1, transport TM domain B
PF00082 (8/8) Subtilase family
TIGR03921 (7/8) type VII secretion-associated serine protease mycosin
TIGR03919 (5/8) type VII secretion protein EccB
precursor_jaccard_groups_14902 186.18 +- 122.33 3 0 0 0 0.11 +- 0.15 3 11

PF12802 (3/3) MarR family
PF07883 (3/3) Cupin domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (3/3) FAD binding domain
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/3) IclR helix-turn-helix domain
PF07690 (2/3) Major Facilitator Superfamily
PF04909 (2/3) Amidohydrolase
PF04199 (2/3) Putative cyclase
PF01614 (2/3) Bacterial transcriptional regulator
PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_28703 1580.73 +- 635.73 2 0 2 0 0.02 +- 0.04 2 14

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_28705 59.40 +- 33.21 2 0 2 0 0.10 +- 0.17 2 5

PF05331 (2/2) Protein of unknown function (DUF742)
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_28707 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_9704 140.33 +- 77.44 4 0 0 0 0.02 +- 0.02 4 3

PF14099 (4/4) Polysaccharide lyase
PF01120 (4/4) Alpha-L-fucosidase
PF00754 (4/4) F5/8 type C domain
precursor_jaccard_groups_18478 75.27 +- 21.48 2 0 0 0 0.03 +- 0.03 2 2

PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_3139 53.91 +- 8.85 7 0 0 0 0.19 +- 0.14 7 13

PF16353 (7/7) Domain of unknown function(DUF4981)
PF04030 (7/7) D-arabinono-1,4-lactone oxidase
PF02929 (7/7) Beta galactosidase small chain
PF02837 (7/7) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (7/7) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (7/7) FAD binding domain
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00480 (7/7) ROK family
PF13412 (6/7) Winged helix-turn-helix DNA-binding
PF13305 (5/7) Tetracyclin repressor-like, C-terminal domain
PF01547 (5/7) Bacterial extracellular solute-binding protein
PF01419 (5/7) Jacalin-like lectin domain
PF00440 (5/7) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_16429 77.19 +- 36.56 2 0 0 0 0.15 +- 0.20 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6978 46.15 +- 9.36 7 0 0 0 0.07 +- 0.06 7 5

TIGR03083 (7/7) uncharacterized Actinobacterial protein TIGR03083
PF13302 (7/7) Acetyltransferase (GNAT) domain
PF11716 (7/7) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (7/7) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (7/7) SCP-2 sterol transfer family
precursor_jaccard_groups_392 30.59 +- 4.59 2 0 0 0 0.07 +- 0.09 2 5

PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09594 (2/2) Glycosyltransferase family 87
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF10531 (1/2) SLBB domain
precursor_jaccard_groups_43400 971.25 +- 3.75 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6976 65.56 +- 9.31 7 0 0 0 0.20 +- 0.07 7 13

PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF18130 (7/7) ATP-grasp N-terminal domain
PF13649 (7/7) Methyltransferase domain
PF13535 (7/7) ATP-grasp domain
PF13378 (7/7) Enolase C-terminal domain-like
PF07690 (7/7) Major Facilitator Superfamily
PF04016 (7/7) Putative heavy-metal chelation
PF02746 (7/7) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00496 (7/7) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00291 (7/7) Pyridoxal-phosphate dependent enzyme
PF00005 (7/7) ABC transporter
PF08352 (5/7) Oligopeptide/dipeptide transporter, C-terminal region
precursor_jaccard_groups_30014 58.29 +- 19.11 2 0 0 2 0.17 +- 0.25 2 5

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01425 (2/2) Amidase
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_30016 16.73 +- 0.60 2 0 0 0 0.12 +- 0.03 2 3

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF04616 (2/2) Glycosyl hydrolases family 43
precursor_jaccard_groups_34206 306.43 +- 83.57 2 0 2 0 0.01 +- 0.00 2 7

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_23451 87.31 +- 0.99 2 0 2 0 0.21 +- 0.36 2 15

TIGR02408 (2/2) ectoine hydroxylase
TIGR02407 (2/2) diaminobutyrate--2-oxoglutarate aminotransferase
TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_11811 42.56 +- 13.89 4 0 0 0 0.09 +- 0.09 4 5

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/4) Major Facilitator Superfamily
PF00107 (4/4) Zinc-binding dehydrogenase
PF01636 (3/4) Phosphotransferase enzyme family
precursor_jaccard_groups_10818 95.56 +- 0.00 2 0 0 0 0.04 +- 0.05 2 3

PF13560 (2/2) Helix-turn-helix domain
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_38297 72.19 +- 21.63 2 0 0 0 0.17 +- 0.28 2 17

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03567 (2/2) FMN reductase
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03358 (2/2) NADPH-dependent FMN reductase
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00483 (2/2) Nucleotidyl transferase
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_10545 213.77 +- 76.76 5 0 0 0 0.02 +- 0.01 5 4

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01713 (5/5) Smr domain
PF00501 (5/5) AMP-binding enzyme
precursor_jaccard_groups_32549 58.81 +- 15.48 2 0 2 0 0.18 +- 0.08 2 6

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF10091 (2/2) Putative glucoamylase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00232 (2/2) Glycosyl hydrolase family 1
precursor_jaccard_groups_24965 8.51 +- 0.39 2 0 1 0 0.23 +- 0.20 2 5

PF13569 (2/2) Domain of unknown function (DUF4132)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00155 (2/2) Aminotransferase class I and II
PF05762 (1/2) VWA domain containing CoxE-like protein
PF00392 (1/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_4831 155.07 +- 79.27 8 0 8 0 0.07 +- 0.13 8 17

TIGR01733 (8/8) amino acid adenylation domain
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF03621 (8/8) MbtH-like protein
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00551 (8/8) Formyl transferase
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF00067 (8/8) Cytochrome P450
TIGR03618 (6/8) PPOX class probable F420-dependent enzyme
PF13385 (6/8) Concanavalin A-like lectin/glucanases superfamily
PF12710 (6/8) haloacid dehalogenase-like hydrolase
PF01243 (6/8) Pyridoxamine 5'-phosphate oxidase
PF00069 (6/8) Protein kinase domain
precursor_jaccard_groups_2555 79.61 +- 20.42 12 0 0 0 0.17 +- 0.06 12 16

TIGR03356 (12/12) beta-galactosidase
TIGR01727 (12/12) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13377 (12/12) Periplasmic binding protein-like domain
PF12911 (12/12) N-terminal TM domain of oligopeptide transport permease C
PF08352 (12/12) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (12/12) Binding-protein-dependent transport system inner membrane component
PF00496 (12/12) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00356 (12/12) Bacterial regulatory proteins, lacI family
PF00232 (12/12) Glycosyl hydrolase family 1
PF00005 (12/12) ABC transporter
PF03425 (10/12) Carbohydrate binding domain (family 11)
PF03160 (10/12) Calx-beta domain
PF01915 (10/12) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (10/12) Glycosyl hydrolase family 3 N terminal domain
PF00754 (9/12) F5/8 type C domain
PF00722 (9/12) Glycosyl hydrolases family 16
precursor_jaccard_groups_34844 85.97 +- 19.08 2 0 2 0 0.12 +- 0.20 2 9

TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13304 (2/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF08241 (2/2) Methyltransferase domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (2/2) ABC transporter
TIGR01426 (1/2) glycosyltransferase, MGT family
precursor_jaccard_groups_24256 27.47 +- 8.39 2 0 0 0 0.16 +- 0.23 2 5

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12172 (2/2) Rubredoxin-like zinc ribbon domain (DUF35_N)
PF08445 (2/2) FR47-like protein
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_40537 1342.00 +- 1238.00 2 0 2 0 0.07 +- 0.23 2 19

TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00083 (2/2) Sugar (and other) transporter
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01751 (1/2) crotonyl-CoA carboxylase/reductase
PF16864 (1/2) Dimerisation domain
PF08241 (1/2) Methyltransferase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00668 (1/2) Condensation domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_34443 502.18 +- 50.68 2 0 0 0 0.01 +- 0.00 2 4

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
precursor_jaccard_groups_7477 301.48 +- 123.37 5 0 0 0 0.02 +- 0.01 5 6

PF07690 (5/5) Major Facilitator Superfamily
PF04909 (5/5) Amidohydrolase
PF04444 (5/5) Catechol dioxygenase N terminus
PF01494 (5/5) FAD binding domain
PF00775 (5/5) Dioxygenase
PF00465 (5/5) Iron-containing alcohol dehydrogenase
precursor_jaccard_groups_3591 96.64 +- 82.42 7 0 0 0 0.06 +- 0.08 7 3

PF02515 (7/7) CoA-transferase family III
PF00082 (7/7) Subtilase family
PF05425 (4/7) Copper resistance protein D
precursor_jaccard_groups_34449 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_28140 60.01 +- 18.17 2 0 0 0 0.15 +- 0.08 2 10

PF14310 (2/2) Fibronectin type III-like domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01381 (2/2) Helix-turn-helix
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF13377 (1/2) Periplasmic binding protein-like domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_44944 83.92 +- 28.63 2 0 1 0 0.10 +- 0.12 2 13

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13580 (2/2) SIS domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13242 (2/2) HAD-hyrolase-like
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
TIGR02199 (1/2) bifunctional protein RfaE, domain II
PF01467 (1/2) Cytidylyltransferase-like
PF00294 (1/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_44763 34.25 +- 15.69 2 0 0 0 0.15 +- 0.31 2 10

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF02872 (2/2) 5'-nucleotidase, C-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
TIGR00838 (1/2) argininosuccinate lyase
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF04343 (1/2) Protein of unknown function, DUF488
PF00206 (1/2) Lyase
precursor_jaccard_groups_29300 38.06 +- 15.06 2 0 2 0 0.12 +- 0.14 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF04140 (2/2) Isoprenylcysteine carboxyl methyltransferase (ICMT) family
PF02797 (2/2) Chalcone and stilbene synthases, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00195 (2/2) Chalcone and stilbene synthases, N-terminal domain
precursor_jaccard_groups_13558 783.61 +- 267.79 4 0 0 0 0.02 +- 0.01 4 6

TIGR03930 (4/4) WXG100 family type VII secretion target
TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
TIGR03919 (4/4) type VII secretion protein EccB
PF06013 (4/4) Proteins of 100 residues with WXG
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
precursor_jaccard_groups_23638 31.27 +- 6.97 2 0 2 0 0.13 +- 0.25 2 8

PF17871 (2/2) AAA lid domain
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF01546 (2/2) Peptidase family M20/M25/M40
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_14043 302.19 +- 237.69 4 0 0 0 0.06 +- 0.11 4 18

TIGR01088 (4/4) 3-dehydroquinate dehydratase, type II
PF18317 (4/4) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (4/4) IclR helix-turn-helix domain
PF08501 (4/4) Shikimate dehydrogenase substrate binding domain
PF07836 (4/4) DmpG-like communication domain
PF07690 (4/4) Major Facilitator Superfamily
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01614 (4/4) Bacterial transcriptional regulator
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF01220 (4/4) Dehydroquinase class II
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (4/4) HMGL-like
PF00083 (4/4) Sugar (and other) transporter
TIGR03217 (3/4) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (3/4) acetaldehyde dehydrogenase (acetylating)
PF09290 (3/4) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (3/4) Semialdehyde dehydrogenase, NAD binding domain
precursor_jaccard_groups_18561 553.90 +- 184.40 3 0 0 0 0.03 +- 0.02 3 12

TIGR01217 (3/3) acetoacetate-CoA ligase
PF16177 (3/3) Acetyl-coenzyme A synthetase N-terminus
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12833 (3/3) Helix-turn-helix domain
PF12625 (3/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF06821 (3/3) Serine hydrolase
PF05853 (3/3) beta-keto acid cleavage enzyme
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (3/3) AMP-binding enzyme
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_23630 60.86 +- 34.51 2 0 2 0 0.21 +- 0.27 2 11

PF13560 (2/2) Helix-turn-helix domain
PF05257 (2/2) CHAP domain
PF01987 (2/2) Mitochondrial biogenesis AIM24
PF01553 (2/2) Acyltransferase
PF01047 (2/2) MarR family
PF00400 (2/2) WD domain, G-beta repeat
TIGR00843 (1/2) benzoate transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12894 (1/2) Anaphase-promoting complex subunit 4 WD40 domain
PF03594 (1/2) Benzoate membrane transport protein
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_43753 252.33 +- 137.67 2 0 0 0 0.02 +- 0.04 2 4

PF04203 (2/2) Sortase domain
PF01590 (2/2) GAF domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_2264 13.82 +- 0.84 2 0 2 0 0.22 +- 0.12 2 6

PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF05853 (2/2) beta-keto acid cleavage enzyme
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_1975 85.03 +- 2.59 2 0 0 0 0.20 +- 0.27 2 14

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13378 (2/2) Enolase C-terminal domain-like
PF09723 (2/2) Zinc ribbon domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR00802 (1/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF03824 (1/2) High-affinity nickel-transport protein
precursor_jaccard_groups_42753 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF15607 (2/2) Bacterial toxin 44
PF12256 (2/2) Insecticide toxin TcdB middle/N-terminal region
PF05593 (2/2) RHS Repeat
PF03534 (2/2) Salmonella virulence plasmid 65kDa B protein
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_2263 62.58 +- 48.11 16 0 16 1 0.08 +- 0.03 16 8

TIGR03150 (16/16) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR01230 (16/16) agmatinase
PF13561 (16/16) Enoyl-(Acyl carrier protein) reductase
PF02801 (16/16) Beta-ketoacyl synthase, C-terminal domain
PF00501 (16/16) AMP-binding enzyme
PF00491 (16/16) Arginase family
PF00109 (16/16) Beta-ketoacyl synthase, N-terminal domain
PF00069 (16/16) Protein kinase domain
precursor_jaccard_groups_34537 168.50 +- 39.50 2 0 0 0 0.03 +- 0.02 2 7

PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_34535 498.95 +- 269.23 2 0 2 2 0.04 +- 0.05 2 17

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF08281 (2/2) Sigma-70, region 4
PF08241 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04542 (2/2) Sigma-70 region 2
PF01661 (2/2) Macro domain
PF01129 (2/2) NAD:arginine ADP-ribosyltransferase
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00881 (2/2) Nitroreductase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_33923 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_2067 154.23 +- 53.87 7 0 0 0 0.01 +- 0.02 7 2

PF02600 (7/7) Disulfide bond formation protein DsbB
PF03807 (6/7) NADP oxidoreductase coenzyme F420-dependent
precursor_jaccard_groups_2066 72.21 +- 91.90 13 0 13 13 0.10 +- 0.24 13 19

TIGR01733 (13/13) amino acid adenylation domain
PF16197 (13/13) Ketoacyl-synthetase C-terminal extension
PF13193 (13/13) AMP-binding enzyme C-terminal domain
PF08659 (13/13) KR domain
PF02801 (13/13) Beta-ketoacyl synthase, C-terminal domain
PF00698 (13/13) Acyl transferase domain
PF00668 (13/13) Condensation domain
PF00550 (13/13) Phosphopantetheine attachment site
PF00501 (13/13) AMP-binding enzyme
PF00109 (13/13) Beta-ketoacyl synthase, N-terminal domain
TIGR03891 (12/13) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (12/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (12/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (12/13) Lantibiotic biosynthesis dehydratase C-term
PF03992 (12/13) Antibiotic biosynthesis monooxygenase
PF02624 (12/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/13) Nitroreductase family
PF00575 (11/13) S1 RNA binding domain
PF04738 (9/13) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_2065 11.79 +- 3.07 14 0 0 0 0.18 +- 0.37 14 4

TIGR00737 (14/14) putative TIM-barrel protein, nifR3 family
PF06386 (14/14) Gas vesicle synthesis protein GvpL/GvpF
PF03364 (14/14) Polyketide cyclase / dehydrase and lipid transport
PF01207 (14/14) Dihydrouridine synthase (Dus)
precursor_jaccard_groups_2062 72.56 +- 23.85 2 0 2 0 0.25 +- 0.29 2 9

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF07350 (1/2) Protein of unknown function (DUF1479)
PF00278 (1/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
precursor_jaccard_groups_2061 41.09 +- 15.79 7 0 0 0 0.08 +- 0.08 7 3

PF08007 (7/7) Cupin superfamily protein
PF06999 (7/7) Sucrase/ferredoxin-like
PF01184 (6/7) GPR1/FUN34/yaaH family
precursor_jaccard_groups_42593 644.06 +- 387.94 2 0 2 0 0.04 +- 0.14 2 26

TIGR03081 (2/2) methylmalonyl-CoA epimerase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01194 (2/2) cyclic peptide transporter
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08659 (2/2) KR domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02195 (2/2) ParB-like nuclease domain
PF01804 (2/2) Penicillin amidase
PF01066 (2/2) CDP-alcohol phosphatidyltransferase
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26615 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
precursor_jaccard_groups_25705 774.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 12

TIGR04469 (2/2) CGA synthase-related protein
TIGR04468 (2/2) arginine 2,3-aminomutase
TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (2/2) cytosylglucuronate decarboxylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF12833 (2/2) Helix-turn-helix domain
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_25703 28.15 +- 5.04 2 0 0 0 0.11 +- 0.07 2 3

PF13489 (2/2) Methyltransferase domain
PF05685 (2/2) Putative restriction endonuclease
PF02082 (2/2) Transcriptional regulator
precursor_jaccard_groups_73 81.58 +- 102.21 22 0 5 0 0.11 +- 0.15 22 2

PF13459 (22/22) 4Fe-4S single cluster domain
PF00067 (22/22) Cytochrome P450
precursor_jaccard_groups_31277 322.67 +- 93.33 2 0 0 0 0.01 +- 0.01 2 4

PF12006 (2/2) Protein of unknown function (DUF3500)
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_5275 32.86 +- 21.78 7 0 0 0 0.11 +- 0.08 7 6

TIGR03668 (7/7) PPOX class probable F420-dependent enzyme, Rv0121 family
PF02133 (7/7) Permease for cytosine/purines, uracil, thiamine, allantoin
PF01243 (7/7) Pyridoxamine 5'-phosphate oxidase
TIGR03619 (6/7) probable F420-dependent oxidoreductase, Rv2161c family
PF04199 (6/7) Putative cyclase
PF00296 (6/7) Luciferase-like monooxygenase
precursor_jaccard_groups_20189 43.20 +- 22.07 3 0 1 0 0.10 +- 0.07 3 5

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03919 (3/3) type VII secretion protein EccB
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/3) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_23702 1072.50 +- 357.50 2 0 0 0 0.01 +- 0.01 2 15

TIGR01928 (2/2) o-succinylbenzoate synthase
PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13378 (2/2) Enolase C-terminal domain-like
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF05199 (2/2) GMC oxidoreductase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00732 (2/2) GMC oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (2/2) Prolyl oligopeptidase family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
precursor_jaccard_groups_26495 29.10 +- 3.56 2 0 0 0 0.14 +- 0.15 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_8842 51.70 +- 17.17 5 0 3 0 0.07 +- 0.11 5 5

PF13305 (5/5) Tetracyclin repressor-like, C-terminal domain
PF00561 (5/5) alpha/beta hydrolase fold
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00150 (5/5) Cellulase (glycosyl hydrolase family 5)
PF18564 (4/5) Glycoside hydrolase family 5 C-terminal domain
precursor_jaccard_groups_2089 392.90 +- 135.87 17 0 16 14 0.01 +- 0.01 17 5

PF13454 (17/17) FAD-NAD(P)-binding
PF13302 (17/17) Acetyltransferase (GNAT) domain
PF02801 (17/17) Beta-ketoacyl synthase, C-terminal domain
PF00109 (17/17) Beta-ketoacyl synthase, N-terminal domain
PF05147 (14/17) Lanthionine synthetase C-like protein
precursor_jaccard_groups_9033 253.82 +- 91.01 5 0 5 0 0.02 +- 0.02 5 16

TIGR01733 (5/5) amino acid adenylation domain
TIGR01188 (5/5) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00838 (5/5) argininosuccinate lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF13535 (5/5) ATP-grasp domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF03767 (5/5) HAD superfamily, subfamily IIIB (Acid phosphatase)
PF00975 (5/5) Thioesterase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
PF00288 (5/5) GHMP kinases N terminal domain
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_42575 29.50 +- 7.64 2 0 2 0 0.07 +- 0.07 2 13

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13160 (2/2) Protein of unknown function (DUF3995)
PF08818 (2/2) Domain of unknown function (DU1801)
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_2081 158.65 +- 104.82 18 0 0 0 0.02 +- 0.01 18 5

PF14200 (18/18) Ricin-type beta-trefoil lectin domain-like
PF05270 (18/18) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03752 (18/18) Short repeats of unknown function
PF00720 (18/18) Subtilisin inhibitor-like
PF00652 (18/18) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_9784 924.40 +- 201.34 5 0 5 0 0.01 +- 0.00 5 16

TIGR04020 (5/5) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF18563 (5/5) TubC N-terminal docking domain
PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08242 (5/5) Methyltransferase domain
PF03621 (5/5) MbtH-like protein
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00698 (5/5) Acyl transferase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00296 (5/5) Luciferase-like monooxygenase
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_2401 13.94 +- 5.21 10 0 0 0 0.17 +- 0.07 10 5

TIGR03802 (10/10) aspartate-alanine antiporter
TIGR03801 (10/10) aspartate 4-decarboxylase
PF06826 (10/10) Predicted Permease Membrane Region
PF02080 (10/10) TrkA-C domain
PF00155 (10/10) Aminotransferase class I and II
precursor_jaccard_groups_7692 113.38 +- 22.39 5 0 5 0 0.02 +- 0.01 5 4

PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_7691 194.17 +- 42.63 5 0 3 0 0.01 +- 0.00 5 5

TIGR02276 (5/5) 40-residue YVTN family beta-propeller repeat
PF16640 (5/5) Bacterial Ig-like domain (group 3)
PF14378 (5/5) PAP2 superfamily
PF09594 (5/5) Glycosyltransferase family 87
PF01833 (5/5) IPT/TIG domain
precursor_jaccard_groups_12952 30.04 +- 9.45 4 0 4 0 0.11 +- 0.18 4 5

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12697 (4/4) Alpha/beta hydrolase family
PF07883 (4/4) Cupin domain
PF07690 (4/4) Major Facilitator Superfamily
PF00069 (4/4) Protein kinase domain
precursor_jaccard_groups_9323 20.40 +- 12.10 2 0 0 0 0.15 +- 0.10 2 1

PF05685 (2/2) Putative restriction endonuclease
precursor_jaccard_groups_39048 173.33 +- 86.67 2 0 0 0 0.02 +- 0.01 2 2

PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_11638 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
precursor_jaccard_groups_18562 441.25 +- 288.15 3 0 0 0 0.09 +- 0.20 3 11

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13490 (3/3) Putative zinc-finger
PF12697 (3/3) Alpha/beta hydrolase family
PF10099 (3/3) Anti-sigma-K factor rskA
PF08281 (3/3) Sigma-70, region 4
PF07103 (3/3) Protein of unknown function (DUF1365)
PF06966 (3/3) Protein of unknown function (DUF1295)
PF04542 (3/3) Sigma-70 region 2
PF02353 (3/3) Mycolic acid cyclopropane synthetase
PF01593 (3/3) Flavin containing amine oxidoreductase
precursor_jaccard_groups_11636 184.00 +- 24.72 3 0 0 0 0.06 +- 0.02 3 9

TIGR01187 (3/3) polyamine ABC transporter, ATP-binding protein
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF01593 (3/3) Flavin containing amine oxidoreductase
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00005 (3/3) ABC transporter
PF00171 (2/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_6744 26.38 +- 12.38 2 0 0 0 0.21 +- 0.29 2 8

TIGR00494 (2/2) protein CrcB
PF09594 (2/2) Glycosyltransferase family 87
PF03088 (2/2) Strictosidine synthase
PF02641 (2/2) Uncharacterized ACR, COG1993
PF02537 (2/2) CrcB-like protein, Camphor Resistance (CrcB)
TIGR00753 (1/2) undecaprenyl-diphosphatase UppP
PF12840 (1/2) Helix-turn-helix domain
PF02673 (1/2) Bacitracin resistance protein BacA
precursor_jaccard_groups_15640 555.81 +- 476.19 2 0 0 0 0.05 +- 0.13 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_33785 65.89 +- 10.21 2 0 0 0 0.19 +- 0.28 2 13

PF13378 (2/2) Enolase C-terminal domain-like
PF13229 (2/2) Right handed beta helix region
PF13183 (2/2) 4Fe-4S dicluster domain
PF11870 (2/2) Domain of unknown function (DUF3390)
PF07859 (2/2) alpha/beta hydrolase fold
PF07729 (2/2) FCD domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02589 (2/2) LUD domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00754 (2/2) F5/8 type C domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_34355 150.50 +- 43.00 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
precursor_jaccard_groups_43554 61.37 +- 13.71 2 0 0 0 0.17 +- 0.33 2 13

TIGR02246 (2/2) conserved hypothetical protein
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF14478 (2/2) Domain of unknown function (DUF4430)
PF13649 (2/2) Methyltransferase domain
PF12822 (2/2) ECF transporter, substrate-specific component
PF04314 (2/2) Copper chaperone PCu(A)C
PF02361 (2/2) Cobalt transport protein
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32361 1165.50 +- 4.50 2 0 0 0 0.01 +- 0.00 2 8

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF09339 (2/2) IclR helix-turn-helix domain
PF08402 (2/2) TOBE domain
PF04199 (2/2) Putative cyclase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_32093 306.94 +- 18.06 2 0 2 0 0.01 +- 0.01 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_32091 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_5180 89.07 +- 17.09 8 0 8 0 0.03 +- 0.04 8 3

PF01965 (8/8) DJ-1/PfpI family
PF00248 (8/8) Aldo/keto reductase family
PF00106 (8/8) short chain dehydrogenase
precursor_jaccard_groups_41497 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_5184 321.97 +- 199.60 8 0 5 0 0.02 +- 0.04 8 4

PF02515 (8/8) CoA-transferase family III
PF00465 (8/8) Iron-containing alcohol dehydrogenase
PF00248 (8/8) Aldo/keto reductase family
PF00067 (8/8) Cytochrome P450
precursor_jaccard_groups_32098 77.88 +- 46.92 2 0 0 0 0.06 +- 0.06 2 6

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00293 (2/2) NUDIX domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF08533 (1/2) Beta-galactosidase C-terminal domain
PF08532 (1/2) Beta-galactosidase trimerisation domain
PF02449 (1/2) Beta-galactosidase
precursor_jaccard_groups_33653 85.65 +- 22.12 2 0 2 0 0.15 +- 0.11 2 13

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12900 (2/2) Pyridoxamine 5'-phosphate oxidase
PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF08281 (2/2) Sigma-70, region 4
PF08220 (2/2) DeoR-like helix-turn-helix domain
PF04542 (2/2) Sigma-70 region 2
PF04188 (2/2) Mannosyltransferase (PIG-V)
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00455 (2/2) DeoR C terminal sensor domain
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_37509 144.33 +- 115.67 2 0 0 0 0.04 +- 0.05 2 2

PF01494 (2/2) FAD binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_2319 237.46 +- 181.87 15 2 13 0 0.03 +- 0.10 13 4

PF13649 (15/15) Methyltransferase domain
PF12697 (15/15) Alpha/beta hydrolase family
PF02441 (15/15) Flavoprotein
PF00005 (15/15) ABC transporter
precursor_jaccard_groups_13777 56.12 +- 11.39 4 0 0 0 0.04 +- 0.02 4 2

PF11706 (4/4) CGNR zinc finger
PF08962 (4/4) Domain of unknown function (DUF1876)
precursor_jaccard_groups_41817 37.78 +- 1.22 2 0 0 0 0.08 +- 0.06 2 4

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF04616 (2/2) Glycosyl hydrolases family 43
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_7767 234.12 +- 123.22 6 0 0 0 0.04 +- 0.05 6 5

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (6/6) Major Facilitator Superfamily
PF01553 (6/6) Acyltransferase
PF01148 (6/6) Cytidylyltransferase family
PF01066 (6/6) CDP-alcohol phosphatidyltransferase
precursor_jaccard_groups_7762 19.34 +- 2.39 6 0 5 0 0.16 +- 0.05 6 4

TIGR00791 (6/6) transporter, gluconate:H+ symporter (GntP) family
PF13378 (6/6) Enolase C-terminal domain-like
PF02746 (6/6) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02447 (6/6) GntP family permease
precursor_jaccard_groups_39688 152.46 +- 41.04 2 0 2 0 0.01 +- 0.01 2 2

PF13810 (2/2) Domain of unknown function (DUF4185)
PF08310 (2/2) LGFP repeat
precursor_jaccard_groups_42023 47.21 +- 8.51 2 0 2 0 0.04 +- 0.03 2 5

TIGR02601 (2/2) autotransporter-associated beta strand repeat
PF12951 (2/2) Passenger-associated-transport-repeat
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF01569 (2/2) PAP2 superfamily
PF01565 (2/2) FAD binding domain
precursor_jaccard_groups_15557 138.06 +- 2.67 2 0 0 0 0.22 +- 0.15 2 12

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00738 (2/2) Rrf2 family protein
PF09084 (2/2) NMT1/THI5 like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/2) Transcriptional regulator
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11558 279.59 +- 240.41 2 0 0 2 0.05 +- 0.12 2 9

PF13360 (2/2) PQQ-like domain
PF06824 (2/2) Metal-independent alpha-mannosidase (GH125)
PF04203 (2/2) Sortase domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_40644 113.76 +- 24.10 2 0 0 0 0.18 +- 0.31 2 5

PF05995 (2/2) Cysteine dioxygenase type I
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF00581 (2/2) Rhodanese-like domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_41233 390.00 +- 130.00 2 0 2 0 0.01 +- 0.00 2 3

TIGR01426 (2/2) glycosyltransferase, MGT family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_9301 17.50 +- 0.34 5 0 0 0 0.17 +- 0.23 5 4

PF13722 (5/5) 5TM C-terminal transporter carbon starvation CstA
PF04328 (5/5) Selenoprotein, putative
PF02554 (5/5) Carbon starvation protein CstA
PF00583 (5/5) Acetyltransferase (GNAT) family
precursor_jaccard_groups_35123 424.72 +- 114.31 2 0 2 0 0.02 +- 0.01 2 12

PF17837 (2/2) 4'-phosphopantetheinyl transferase N-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07690 (2/2) Major Facilitator Superfamily
PF03060 (2/2) Nitronate monooxygenase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01488 (2/2) Shikimate / quinate 5-dehydrogenase
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_12734 23.17 +- 6.67 3 0 3 0 0.10 +- 0.11 3 7

PF13407 (3/3) Periplasmic binding protein domain
PF08376 (3/3) Nitrate and nitrite sensing
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF00672 (3/3) HAMP domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_jaccard_groups_1322 62.94 +- 13.05 28 0 0 0 0.15 +- 0.13 28 12

TIGR00247 (28/28) conserved hypothetical protein, YceG family
TIGR00026 (28/28) deazaflavin-dependent oxidoreductase, nitroreductase family
PF18029 (28/28) Glyoxalase-like domain
PF13411 (28/28) MerR HTH family regulatory protein
PF09278 (28/28) MerR, DNA binding
PF07729 (28/28) FCD domain
PF07690 (28/28) Major Facilitator Superfamily
PF04075 (28/28) F420H(2)-dependent quinone reductase
PF02618 (28/28) YceG-like family
PF00392 (27/28) Bacterial regulatory proteins, gntR family
TIGR01048 (25/28) diaminopimelate decarboxylase
PF02784 (25/28) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
precursor_jaccard_groups_27800 666.40 +- 418.72 2 0 0 0 0.03 +- 0.06 2 21

TIGR03217 (2/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/2) acetaldehyde dehydrogenase (acetylating)
TIGR01088 (2/2) 3-dehydroquinate dehydratase, type II
PF18317 (2/2) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (2/2) IclR helix-turn-helix domain
PF09290 (2/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08501 (2/2) Shikimate dehydrogenase substrate binding domain
PF07836 (2/2) DmpG-like communication domain
PF07690 (2/2) Major Facilitator Superfamily
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF01220 (2/2) Dehydroquinase class II
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (2/2) HMGL-like
PF00083 (2/2) Sugar (and other) transporter
PF01488 (1/2) Shikimate / quinate 5-dehydrogenase
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00665 (1/2) Integrase core domain
precursor_jaccard_groups_2309 53.53 +- 1.90 5 0 0 0 0.21 +- 0.33 5 15

TIGR02115 (5/5) K+-transporting ATPase, F subunit
TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR01497 (5/5) K+-transporting ATPase, B subunit
TIGR00681 (5/5) K+-transporting ATPase, C subunit
TIGR00680 (5/5) K+-transporting ATPase, A subunit
TIGR00374 (5/5) TIGR00374 family protein
PF09604 (5/5) F subunit of K+-transporting ATPase (Potass_KdpF)
PF03814 (5/5) Potassium-transporting ATPase A subunit
PF03706 (5/5) Lysylphosphatidylglycerol synthase TM region
PF02702 (5/5) Osmosensitive K+ channel His kinase sensor domain
PF02669 (5/5) K+-transporting ATPase, c chain
PF01814 (5/5) Hemerythrin HHE cation binding domain
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00582 (5/5) Universal stress protein family
PF00122 (5/5) E1-E2 ATPase
precursor_jaccard_groups_7704 103.82 +- 41.92 4 0 0 0 0.02 +- 0.02 4 2

PF07336 (4/4) Putative stress-induced transcription regulator
PF00069 (4/4) Protein kinase domain
precursor_jaccard_groups_6416 26.42 +- 6.37 2 0 2 0 0.20 +- 0.11 2 11

TIGR04316 (2/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
TIGR02275 (2/2) (2,3-dihydroxybenzoyl)adenylate synthase
TIGR00543 (2/2) isochorismate synthase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07497 (2/2) Rho termination factor, RNA-binding domain
PF00857 (2/2) Isochorismatase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00006 (2/2) ATP synthase alpha/beta family, nucleotide-binding domain
precursor_jaccard_groups_2618 43.61 +- 22.81 6 0 0 0 0.18 +- 0.21 6 9

TIGR03718 (6/6) integral membrane protein, TerC family
PF05331 (6/6) Protein of unknown function (DUF742)
PF03741 (6/6) Integral membrane protein TerC family
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00356 (6/6) Bacterial regulatory proteins, lacI family
PF13407 (5/6) Periplasmic binding protein domain
PF18029 (4/6) Glyoxalase-like domain
PF00903 (3/6) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_18015 109.47 +- 59.73 3 0 2 0 0.07 +- 0.06 3 4

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF13411 (3/3) MerR HTH family regulatory protein
PF08534 (3/3) Redoxin
PF00701 (3/3) Dihydrodipicolinate synthetase family
precursor_jaccard_groups_22436 18.38 +- 3.53 3 0 0 0 0.18 +- 0.15 3 7

TIGR01840 (3/3) esterase, PHB depolymerase family
PF13701 (3/3) Transposase DDE domain group 1
PF10605 (3/3) 3HB-oligomer hydrolase (3HBOH)
PF10503 (3/3) Esterase PHB depolymerase
PF07519 (3/3) Tannase and feruloyl esterase
PF00144 (3/3) Beta-lactamase
PF00041 (3/3) Fibronectin type III domain
precursor_jaccard_groups_7701 53.23 +- 35.55 6 0 0 0 0.08 +- 0.17 6 4

PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_27754 87.00 +- 33.00 2 0 1 0 0.11 +- 0.12 2 14

PF13183 (2/2) 4Fe-4S dicluster domain
PF07063 (2/2) Domain of unknown function (DUF1338)
PF05378 (2/2) Hydantoinase/oxoprolinase N-terminal region
PF04471 (2/2) Restriction endonuclease
PF04191 (2/2) Phospholipid methyltransferase
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02754 (2/2) Cysteine-rich domain
PF02538 (2/2) Hydantoinase B/oxoprolinase
PF01968 (2/2) Hydantoinase/oxoprolinase
PF01565 (2/2) FAD binding domain
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
precursor_jaccard_groups_12605 39.22 +- 0.31 3 0 0 0 0.23 +- 0.36 3 8

TIGR01891 (3/3) amidohydrolase
TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13649 (3/3) Methyltransferase domain
PF07687 (3/3) Peptidase dimerisation domain
PF01053 (3/3) Cys/Met metabolism PLP-dependent enzyme
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_1218 65.30 +- 30.67 29 0 29 0 0.10 +- 0.09 29 5

PF07690 (29/29) Major Facilitator Superfamily
PF02826 (29/29) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02782 (29/29) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (29/29) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (29/29) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_871 118.03 +- 90.83 4 0 0 4 0.24 +- 0.06 4 32

TIGR03026 (4/4) nucleotide sugar dehydrogenase
TIGR03025 (4/4) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF16889 (4/4) Heparinase II/III N-terminus
PF16254 (4/4) Domain of unknown function (DUF4910)
PF16221 (4/4) winged helix-turn-helix
PF13727 (4/4) CoA-binding domain
PF13692 (4/4) Glycosyl transferases group 1
PF13579 (4/4) Glycosyl transferase 4-like domain
PF13537 (4/4) Glutamine amidotransferase domain
PF13489 (4/4) Methyltransferase domain
PF13439 (4/4) Glycosyltransferase Family 4
PF13229 (4/4) Right handed beta helix region
PF08484 (4/4) C-methyltransferase C-terminal domain
PF08421 (4/4) Putative zinc binding domain
PF07940 (4/4) Heparinase II/III-like protein
PF04230 (4/4) Polysaccharide pyruvyl transferase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (4/4) Chain length determinant protein
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF02397 (4/4) Bacterial sugar transferase
PF01408 (4/4) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00908 (4/4) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (4/4) Asparagine synthase
PF00535 (4/4) Glycosyl transferase family 2
PF00534 (4/4) Glycosyl transferases group 1
PF00202 (4/4) Aminotransferase class-III
PF00107 (4/4) Zinc-binding dehydrogenase
TIGR01221 (2/4) dTDP-4-dehydrorhamnose 3,5-epimerase
precursor_jaccard_groups_15559 47.93 +- 14.79 3 0 0 0 0.17 +- 0.29 3 10

TIGR01361 (3/3) 3-deoxy-7-phosphoheptulonate synthase
PF18152 (3/3) DAHP synthase ferredoxin-like domain
PF08031 (3/3) Berberine and berberine like
PF07883 (3/3) Cupin domain
PF01565 (3/3) FAD binding domain
PF01494 (3/3) FAD binding domain
PF00793 (3/3) DAHP synthetase I family
PF00425 (3/3) chorismate binding enzyme
PF00117 (3/3) Glutamine amidotransferase class-I
PF07690 (2/3) Major Facilitator Superfamily
precursor_jaccard_groups_10395 211.18 +- 96.47 5 0 5 0 0.02 +- 0.01 5 3

TIGR03930 (5/5) WXG100 family type VII secretion target
PF06013 (5/5) Proteins of 100 residues with WXG
PF00082 (5/5) Subtilase family
precursor_jaccard_groups_4580 114.23 +- 30.02 9 0 0 0 0.17 +- 0.09 9 4

PF13416 (9/9) Bacterial extracellular solute-binding protein
PF10091 (9/9) Putative glucoamylase
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00232 (9/9) Glycosyl hydrolase family 1
precursor_jaccard_groups_36752 22.81 +- 5.24 2 0 0 0 0.14 +- 0.12 2 5

PF08241 (2/2) Methyltransferase domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_26530 26.35 +- 8.83 2 0 0 0 0.13 +- 0.10 2 5

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_9565 151.71 +- 129.74 2 0 2 0 0.10 +- 0.14 2 7

TIGR04316 (2/2) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF01474 (2/2) Class-II DAHP synthetase family
PF00857 (2/2) Isochorismatase family
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_2899 647.25 +- 555.91 9 0 0 0 0.04 +- 0.08 9 9

TIGR00711 (9/9) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (9/9) Tetracyclin repressor-like, C-terminal domain
PF14224 (9/9) Domain of unknown function (DUF4331)
PF08240 (9/9) Alcohol dehydrogenase GroES-like domain
PF07690 (9/9) Major Facilitator Superfamily
PF00925 (9/9) GTP cyclohydrolase II
PF00440 (9/9) Bacterial regulatory proteins, tetR family
PF00107 (9/9) Zinc-binding dehydrogenase
PF04686 (5/9) Streptomyces sporulation and cell division protein, SsgA
precursor_jaccard_groups_5057 96.30 +- 21.23 9 0 9 0 0.13 +- 0.10 9 11

TIGR03860 (9/9) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (9/9) FMN reductase
TIGR00738 (9/9) Rrf2 family protein
PF13743 (9/9) Thioredoxin
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF03358 (9/9) NADPH-dependent FMN reductase
PF02082 (9/9) Transcriptional regulator
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (9/9) Luciferase-like monooxygenase
PF00005 (9/9) ABC transporter
precursor_jaccard_groups_7901 106.88 +- 99.20 6 0 6 0 0.06 +- 0.06 6 5

PF07690 (6/6) Major Facilitator Superfamily
PF05893 (6/6) Acyl-CoA reductase (LuxC)
PF04443 (6/6) Acyl-protein synthetase, LuxE
PF00583 (6/6) Acetyltransferase (GNAT) family
PF00501 (6/6) AMP-binding enzyme
precursor_jaccard_groups_22099 263.92 +- 28.11 3 0 0 0 0.07 +- 0.13 3 15

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13468 (3/3) Glyoxalase-like domain
PF13247 (3/3) 4Fe-4S dicluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF04909 (3/3) Amidohydrolase
PF03595 (3/3) Voltage-dependent anion channel
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF01494 (3/3) FAD binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
precursor_jaccard_groups_13952 153.43 +- 41.44 4 0 0 4 0.04 +- 0.03 4 10

TIGR03026 (4/4) nucleotide sugar dehydrogenase
TIGR01536 (4/4) asparagine synthase (glutamine-hydrolyzing)
PF13537 (4/4) Glutamine amidotransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (4/4) Asparagine synthase
precursor_jaccard_groups_20310 17.34 +- 2.16 2 0 0 0 0.16 +- 0.13 2 4

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF08282 (1/2) haloacid dehalogenase-like hydrolase
precursor_jaccard_groups_27620 17.03 +- 0.90 2 0 0 0 0.12 +- 0.15 2 5

TIGR01350 (2/2) dihydrolipoyl dehydrogenase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01638 (2/2) HxlR-like helix-turn-helix
precursor_jaccard_groups_1035 73.35 +- 38.35 16 0 16 0 0.17 +- 0.21 16 20

PF01041 (16/16) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (16/16) Thioesterase domain
PF00201 (16/16) UDP-glucoronosyl and UDP-glucosyl transferase
PF00067 (16/16) Cytochrome P450
TIGR00566 (14/16) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (14/16) aminodeoxychorismate synthase, component I
PF04715 (14/16) Anthranilate synthase component I, N terminal region
PF00425 (14/16) chorismate binding enzyme
PF00117 (14/16) Glutamine amidotransferase class-I
PF13193 (12/16) AMP-binding enzyme C-terminal domain
PF01061 (12/16) ABC-2 type transporter
PF00698 (12/16) Acyl transferase domain
PF00550 (12/16) Phosphopantetheine attachment site
PF00501 (12/16) AMP-binding enzyme
PF00109 (12/16) Beta-ketoacyl synthase, N-terminal domain
PF00005 (12/16) ABC transporter
TIGR01188 (11/16) daunorubicin resistance ABC transporter, ATP-binding protein
PF16197 (11/16) Ketoacyl-synthetase C-terminal extension
PF13370 (11/16) 4Fe-4S single cluster domain of Ferredoxin I
PF02801 (11/16) Beta-ketoacyl synthase, C-terminal domain
precursor_jaccard_groups_8785 61.56 +- 8.87 3 0 0 0 0.20 +- 0.09 3 19

TIGR01810 (3/3) choline dehydrogenase
TIGR01374 (3/3) sarcosine oxidase, delta subunit family
TIGR01373 (3/3) sarcosine oxidase, beta subunit family
TIGR01186 (3/3) glycine betaine/L-proline transport ATP binding subunit
PF17806 (3/3) Sarcosine oxidase A3 domain
PF16350 (3/3) FAD dependent oxidoreductase central domain
PF13510 (3/3) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (3/3) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF05199 (3/3) GMC oxidoreductase
PF04268 (3/3) Sarcosine oxidase, gamma subunit family
PF04267 (3/3) Sarcosine oxidase, delta subunit family
PF04069 (3/3) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (3/3) Aminomethyltransferase folate-binding domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00732 (3/3) GMC oxidoreductase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_37336 23.45 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_8780 22.50 +- 3.18 5 0 0 0 0.18 +- 0.17 5 5

PF13564 (5/5) DoxX-like family
PF11139 (5/5) Sap, sulfolipid-1-addressing protein
PF07690 (5/5) Major Facilitator Superfamily
PF04029 (5/5) 2-phosphosulpholactate phosphatase
PF01494 (5/5) FAD binding domain
precursor_jaccard_groups_19387 201.33 +- 81.56 3 0 0 0 0.01 +- 0.01 3 4

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF00092 (3/3) von Willebrand factor type A domain
precursor_jaccard_groups_21748 14.15 +- 8.70 3 0 0 0 0.19 +- 0.17 3 4

PF14019 (3/3) Protein of unknown function (DUF4235)
PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01814 (3/3) Hemerythrin HHE cation binding domain
precursor_jaccard_groups_19380 60.94 +- 34.59 3 0 0 0 0.20 +- 0.15 3 9

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (3/3) YD repeat (two copies)
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/3) TadE-like protein
PF05593 (3/3) RHS Repeat
PF03527 (3/3) RHS protein
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF14412 (2/3) A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
precursor_jaccard_groups_26409 78.36 +- 10.26 2 0 0 0 0.15 +- 0.11 2 20

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01186 (2/2) glycine betaine/L-proline transport ATP binding subunit
PF16350 (2/2) FAD dependent oxidoreductase central domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF17829 (1/2) Gylcosyl hydrolase family 115 C-terminal domain
PF17806 (1/2) Sarcosine oxidase A3 domain
PF15979 (1/2) Glycosyl hydrolase family 115
PF14099 (1/2) Polysaccharide lyase
PF13460 (1/2) NAD(P)H-binding
PF04268 (1/2) Sarcosine oxidase, gamma subunit family
precursor_jaccard_groups_6316 88.12 +- 48.67 7 0 7 0 0.06 +- 0.03 7 11

TIGR02814 (7/7) PfaD family protein
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF14765 (7/7) Polyketide synthase dehydratase
PF08659 (7/7) KR domain
PF07993 (7/7) Male sterility protein
PF07977 (7/7) FabA-like domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF00753 (7/7) Metallo-beta-lactamase superfamily
PF00698 (7/7) Acyl transferase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_29976 16.12 +- 1.61 2 0 0 0 0.19 +- 0.23 2 4

PF17935 (2/2) Tetracyclin repressor-like, C-terminal domain
PF01810 (2/2) LysE type translocator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_29973 57.78 +- 28.89 2 0 0 0 0.05 +- 0.03 2 2

PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_42807 1032.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 8

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_40508 24.36 +- 1.42 2 0 2 0 0.12 +- 0.27 2 4

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF00501 (2/2) AMP-binding enzyme
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_21166 1225.09 +- 465.17 3 0 3 3 0.01 +- 0.01 3 9

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR04353 (2/3) PqqD family protein, HPr-rel-A system
PF13646 (2/3) HEAT repeats
PF13411 (2/3) MerR HTH family regulatory protein
precursor_jaccard_groups_21749 106.97 +- 28.68 3 0 0 0 0.12 +- 0.15 3 10

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_12559 53.34 +- 5.07 4 0 0 0 0.21 +- 0.18 4 10

TIGR02429 (4/4) 3-oxoacid CoA-transferase, A subunit
TIGR02428 (4/4) 3-oxoacid CoA-transferase, B subunit
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF07883 (4/4) Cupin domain
PF04909 (4/4) Amidohydrolase
PF04199 (4/4) Putative cyclase
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (4/4) FAD binding domain
PF01144 (4/4) Coenzyme A transferase
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_16266 145.12 +- 48.38 2 0 0 0 0.10 +- 0.20 2 11

TIGR02103 (2/2) alpha-1,6-glucosidases, pullulanase-type
PF17967 (2/2) Pullulanase N2 domain
PF11852 (2/2) Domain of unknown function (DUF3372)
PF03714 (2/2) Bacterial pullanase-associated domain
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (2/2) Alpha amylase, C-terminal all-beta domain
PF01356 (2/2) Alpha amylase inhibitor
PF00686 (2/2) Starch binding domain
PF00128 (2/2) Alpha amylase, catalytic domain
PF03176 (1/2) MMPL family
PF00589 (1/2) Phage integrase family
precursor_jaccard_groups_37200 585.19 +- 128.43 2 0 2 2 0.05 +- 0.03 2 11

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07702 (2/2) UTRA domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_5463 166.19 +- 151.00 8 0 4 0 0.08 +- 0.14 8 13

TIGR01509 (8/8) HAD hydrolase, family IA, variant 3
PF13560 (8/8) Helix-turn-helix domain
PF12900 (8/8) Pyridoxamine 5'-phosphate oxidase
PF12724 (8/8) Flavodoxin domain
PF12679 (8/8) ABC-2 family transporter protein
PF08962 (8/8) Domain of unknown function (DUF1876)
PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF03636 (8/8) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (8/8) Glycosyl hydrolase family 65 central catalytic domain
PF00702 (8/8) haloacid dehalogenase-like hydrolase
PF00582 (8/8) Universal stress protein family
PF00107 (8/8) Zinc-binding dehydrogenase
PF00005 (8/8) ABC transporter
precursor_jaccard_groups_8672 307.75 +- 125.21 4 0 0 0 0.01 +- 0.00 4 2

PF00089 (4/4) Trypsin
PF13517 (3/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
precursor_jaccard_groups_26393 292.50 +- 97.50 2 0 2 0 0.01 +- 0.00 2 3

PF03928 (2/2) Haem-degrading
PF03795 (2/2) YCII-related domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_12550 65.96 +- 56.10 4 0 0 0 0.12 +- 0.09 4 5

PF12697 (4/4) Alpha/beta hydrolase family
PF05141 (4/4) Pyoverdine/dityrosine biosynthesis protein
PF00067 (4/4) Cytochrome P450
PF12833 (3/4) Helix-turn-helix domain
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_5464 107.83 +- 59.26 7 0 0 0 0.04 +- 0.06 7 2

PF01557 (7/7) Fumarylacetoacetate (FAA) hydrolase family
PF00753 (7/7) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_8677 82.17 +- 32.78 5 0 5 5 0.07 +- 0.08 5 5

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (5/5) Asparagine synthase
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_26664 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_522 675.68 +- 902.40 57 0 57 57 0.04 +- 0.03 57 9

TIGR03891 (56/57) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (56/57) Lantibiotic biosynthesis dehydratase C-term
PF05147 (56/57) Lanthionine synthetase C-like protein
PF04738 (56/57) Lantibiotic dehydratase, N terminus
PF00196 (56/57) Bacterial regulatory proteins, luxR family
PF00005 (56/57) ABC transporter
PF05139 (55/57) Erythromycin esterase
PF00296 (55/57) Luciferase-like monooxygenase
PF00392 (42/57) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_11044 675.26 +- 414.40 4 0 4 0 0.03 +- 0.12 4 20

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01198 (4/4) 6-phosphogluconolactonase
PF17668 (4/4) Acetyltransferase (GNAT) domain
PF13530 (4/4) Sterol carrier protein domain
PF13527 (4/4) Acetyltransferase (GNAT) domain
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF08544 (4/4) GHMP kinases C terminal
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF02709 (4/4) N-terminal domain of galactosyltransferase
PF01761 (4/4) 3-dehydroquinate synthase
PF01182 (4/4) Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00834 (4/4) Ribulose-phosphate 3 epimerase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00293 (4/4) NUDIX domain
PF00288 (4/4) GHMP kinases N terminal domain
PF07676 (3/4) WD40-like Beta Propeller Repeat
PF01979 (3/4) Amidohydrolase family
precursor_jaccard_groups_21560 458.67 +- 0.00 3 0 0 0 0.01 +- 0.00 3 9

TIGR03025 (3/3) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (3/3) Glycosyl transferases group 1
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF13439 (3/3) Glycosyltransferase Family 4
PF04932 (3/3) O-Antigen ligase
PF03023 (3/3) Lipid II flippase MurJ
PF02397 (3/3) Bacterial sugar transferase
PF01522 (3/3) Polysaccharide deacetylase
PF00534 (3/3) Glycosyl transferases group 1
precursor_jaccard_groups_8478 121.57 +- 18.59 3 0 0 0 0.02 +- 0.01 3 5

TIGR00180 (3/3) ParB/RepB/Spo0J family partition protein
PF13614 (3/3) AAA domain
PF03417 (3/3) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02195 (3/3) ParB-like nuclease domain
PF00753 (3/3) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_599 299.54 +- 291.47 4 0 1 0 0.03 +- 0.04 4 2

PF08007 (4/4) Cupin superfamily protein
PF00248 (4/4) Aldo/keto reductase family
precursor_jaccard_groups_28853 33.84 +- 0.11 2 0 2 0 0.15 +- 0.21 2 9

PF13439 (2/2) Glycosyltransferase Family 4
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF01638 (2/2) HxlR-like helix-turn-helix
PF00534 (2/2) Glycosyl transferases group 1
precursor_jaccard_groups_17655 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4028 110.24 +- 72.03 7 0 0 0 0.21 +- 0.28 7 17

TIGR00765 (7/7) YihY family inner membrane protein
TIGR00105 (7/7) ribosomal protein bL31
PF05922 (7/7) Peptidase inhibitor I9
PF03631 (7/7) Virulence factor BrkB
PF02770 (7/7) Acyl-CoA dehydrogenase, middle domain
PF01756 (7/7) Acyl-CoA oxidase
PF01497 (7/7) Periplasmic binding protein
PF01197 (7/7) Ribosomal protein L31
PF00583 (7/7) Acetyltransferase (GNAT) family
PF00294 (7/7) pfkB family carbohydrate kinase
PF00082 (7/7) Subtilase family
PF11941 (6/7) Domain of unknown function (DUF3459)
PF07705 (6/7) CARDB
PF00754 (6/7) F5/8 type C domain
PF00128 (6/7) Alpha amylase, catalytic domain
PF01032 (4/7) FecCD transport family
PF00005 (4/7) ABC transporter
precursor_jaccard_groups_10973 14.20 +- 6.16 2 0 0 0 0.17 +- 0.24 2 6

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF07488 (2/2) Glycosyl hydrolase family 67 middle domain
PF07477 (2/2) Glycosyl hydrolase family 67 C-terminus
PF00754 (2/2) F5/8 type C domain
precursor_jaccard_groups_10972 73.66 +- 35.41 5 0 0 0 0.11 +- 0.14 5 4

PF08241 (5/5) Methyltransferase domain
PF00293 (5/5) NUDIX domain
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_15810 81.02 +- 28.93 3 0 3 0 0.13 +- 0.23 3 12

PF13924 (3/3) Lipocalin-like domain
PF12697 (3/3) Alpha/beta hydrolase family
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF04673 (3/3) Polyketide synthesis cyclase
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF00550 (3/3) Phosphopantetheine attachment site
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00106 (3/3) short chain dehydrogenase
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_4025 219.74 +- 40.26 2 0 0 0 0.02 +- 0.02 2 4

PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG
PF01872 (1/2) RibD C-terminal domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_5407 28.18 +- 2.88 3 0 0 0 0.15 +- 0.17 3 11

PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14078 (3/3) Domain of unknown function (DUF4259)
PF13649 (3/3) Methyltransferase domain
PF06386 (3/3) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (3/3) Gas vesicle synthesis protein GvpO
PF05121 (3/3) Gas vesicle protein K
PF05120 (3/3) Gas vesicle protein G
PF03780 (3/3) Asp23 family, cell envelope-related function
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF00857 (3/3) Isochorismatase family
PF00741 (3/3) Gas vesicle protein
precursor_jaccard_groups_258 60.38 +- 38.60 43 0 3 43 0.07 +- 0.05 43 4

PF13575 (43/43) Domain of unknown function (DUF4135)
PF08007 (43/43) Cupin superfamily protein
PF05147 (43/43) Lanthionine synthetase C-like protein
PF06189 (40/43) 5'-nucleotidase
precursor_jaccard_groups_5997 173.68 +- 35.26 5 0 1 0 0.12 +- 0.17 5 19

PF17853 (5/5) GGDEF-like domain
PF14542 (5/5) GCN5-related N-acetyl-transferase
PF14525 (5/5) AraC-binding-like domain
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13191 (5/5) AAA ATPase domain
PF12833 (5/5) Helix-turn-helix domain
PF12697 (5/5) Alpha/beta hydrolase family
PF07969 (5/5) Amidohydrolase family
PF07859 (5/5) alpha/beta hydrolase fold
PF07681 (5/5) DoxX
PF01547 (5/5) Bacterial extracellular solute-binding protein
PF01184 (5/5) GPR1/FUN34/yaaH family
PF00857 (5/5) Isochorismatase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00210 (5/5) Ferritin-like domain
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF07992 (3/5) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (3/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
precursor_jaccard_groups_253 224.84 +- 107.02 35 2 33 35 0.05 +- 0.08 33 4

PF05147 (35/35) Lanthionine synthetase C-like protein
PF01061 (35/35) ABC-2 type transporter
PF00069 (35/35) Protein kinase domain
PF00005 (35/35) ABC transporter
precursor_jaccard_groups_44506 188.42 +- 112.58 2 0 2 0 0.10 +- 0.25 2 13

TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF08241 (2/2) Methyltransferase domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_256 123.70 +- 117.95 28 0 26 0 0.10 +- 0.19 28 4

PF07690 (28/28) Major Facilitator Superfamily
PF00484 (28/28) Carbonic anhydrase
PF03756 (25/28) A-factor biosynthesis hotdog domain
PF00916 (25/28) Sulfate permease family
precursor_jaccard_groups_21739 143.31 +- 60.07 3 0 0 0 0.06 +- 0.19 3 14

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF09334 (3/3) tRNA synthetases class I (M)
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02274 (3/3) Amidinotransferase
PF01266 (3/3) FAD dependent oxidoreductase
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF04073 (2/3) Aminoacyl-tRNA editing domain
PF03738 (2/3) Glutathionylspermidine synthase preATP-grasp
precursor_jaccard_groups_413 222.88 +- 226.22 57 0 8 0 0.07 +- 0.07 57 13

TIGR01850 (57/57) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (57/57) alpha-L-glutamate ligase, RimK family
PF08443 (57/57) RimK-like ATP-grasp domain
PF02812 (57/57) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF01118 (57/57) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (57/57) Amino acid kinase family
PF00682 (57/57) HMGL-like
PF00501 (57/57) AMP-binding enzyme
PF00208 (57/57) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00117 (57/57) Glutamine amidotransferase class-I
PF13193 (56/57) AMP-binding enzyme C-terminal domain
PF00155 (49/57) Aminotransferase class I and II
PF02774 (37/57) Semialdehyde dehydrogenase, dimerisation domain
precursor_jaccard_groups_1517 26.70 +- 22.19 14 0 12 0 0.19 +- 0.29 14 5

PF09056 (14/14) Prokaryotic phospholipase A2
PF03621 (14/14) MbtH-like protein
PF03403 (14/14) Platelet-activating factor acetylhydrolase, isoform II
PF02153 (14/14) Prephenate dehydrogenase
PF00005 (14/14) ABC transporter
precursor_jaccard_groups_5516 98.12 +- 43.92 8 0 8 0 0.11 +- 0.18 8 20

TIGR04020 (8/8) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (8/8) amino acid adenylation domain
PF16197 (8/8) Ketoacyl-synthetase C-terminal extension
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13193 (8/8) AMP-binding enzyme C-terminal domain
PF07690 (8/8) Major Facilitator Superfamily
PF03067 (8/8) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (8/8) Beta-ketoacyl synthase, C-terminal domain
PF02127 (8/8) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (8/8) Thioesterase domain
PF00877 (8/8) NlpC/P60 family
PF00698 (8/8) Acyl transferase domain
PF00668 (8/8) Condensation domain
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00296 (8/8) Luciferase-like monooxygenase
PF00202 (8/8) Aminotransferase class-III
PF00109 (8/8) Beta-ketoacyl synthase, N-terminal domain
PF01145 (6/8) SPFH domain / Band 7 family
PF12158 (5/8) Protein of unknown function (DUF3592)
precursor_jaccard_groups_28822 379.29 +- 20.56 2 0 0 0 0.04 +- 0.09 2 15

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF14657 (2/2) Arm DNA-binding domain
PF13612 (2/2) Transposase DDE domain
PF13520 (2/2) Amino acid permease
PF13424 (2/2) Tetratricopeptide repeat
PF01636 (2/2) Phosphotransferase enzyme family
PF01381 (2/2) Helix-turn-helix
PF01225 (2/2) Mur ligase family, catalytic domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00589 (2/2) Phage integrase family
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_19834 67.48 +- 4.29 3 0 0 0 0.18 +- 0.23 3 15

TIGR02980 (3/3) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF05227 (3/3) CHASE3 domain
PF04545 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF04539 (3/3) Sigma-70 region 3
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01047 (3/3) MarR family
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_37446 146.83 +- 113.17 2 0 0 0 0.05 +- 0.08 2 7

PF13385 (2/2) Concanavalin A-like lectin/glucanases superfamily
PF07691 (2/2) PA14 domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00561 (2/2) alpha/beta hydrolase fold
PF08386 (1/2) TAP-like protein
precursor_jaccard_groups_45001 200.74 +- 113.70 2 0 0 0 0.14 +- 0.27 2 12

PF11958 (2/2) Domain of unknown function (DUF3472)
PF05331 (2/2) Protein of unknown function (DUF742)
PF04472 (2/2) Cell division protein SepF
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF12643 (1/2) MazG-like family
precursor_jaccard_groups_42886 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_25065 453.00 +- 63.00 2 0 0 0 0.01 +- 0.00 2 4

PF05853 (2/2) beta-keto acid cleavage enzyme
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_671 109.55 +- 55.41 46 0 0 0 0.05 +- 0.04 46 7

PF02668 (46/46) Taurine catabolism dioxygenase TauD, TfdA family
PF01925 (46/46) Sulfite exporter TauE/SafE
PF01070 (46/46) FMN-dependent dehydrogenase
TIGR00843 (44/46) benzoate transporter
PF03594 (44/46) Benzoate membrane transport protein
PF12697 (39/46) Alpha/beta hydrolase family
PF12897 (29/46) Alanine-glyoxylate amino-transferase
precursor_jaccard_groups_670 203.30 +- 256.64 4 0 0 0 0.04 +- 0.05 4 2

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase
precursor_jaccard_groups_8262 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family
precursor_jaccard_groups_44683 287.38 +- 128.62 2 0 2 0 0.02 +- 0.02 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF07730 (2/2) Histidine kinase
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00122 (2/2) E1-E2 ATPase
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_21013 393.40 +- 239.84 3 0 3 0 0.12 +- 0.31 3 20

TIGR02039 (3/3) sulfate adenylyltransferase, small subunit
TIGR02034 (3/3) sulfate adenylyltransferase, large subunit
TIGR00670 (3/3) aspartate carbamoyltransferase
TIGR00455 (3/3) adenylyl-sulfate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01583 (3/3) Adenylylsulphate kinase
PF01507 (3/3) Phosphoadenosine phosphosulfate reductase family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00459 (3/3) Inositol monophosphatase family
PF00326 (3/3) Prolyl oligopeptidase family
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
PF00009 (3/3) Elongation factor Tu GTP binding domain
precursor_jaccard_groups_11951 85.60 +- 28.46 2 0 0 0 0.12 +- 0.25 2 21

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF18130 (2/2) ATP-grasp N-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF14518 (2/2) Iron-containing redox enzyme
PF13535 (2/2) ATP-grasp domain
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00988 (2/2) Carbamoyl-phosphate synthase small chain, CPSase domain
TIGR01369 (1/2) carbamoyl-phosphate synthase, large subunit
TIGR01368 (1/2) carbamoyl-phosphate synthase, small subunit
PF02787 (1/2) Carbamoyl-phosphate synthetase large chain, oligomerisation domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02142 (1/2) MGS-like domain
PF00117 (1/2) Glutamine amidotransferase class-I
precursor_jaccard_groups_30752 123.80 +- 33.22 2 0 2 2 0.17 +- 0.09 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_17386 459.00 +- 99.71 3 0 1 3 0.01 +- 0.00 3 10

TIGR03822 (3/3) lysine-2,3-aminomutase-related protein
PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF13649 (3/3) Methyltransferase domain
PF13480 (3/3) Acetyltransferase (GNAT) domain
PF12697 (3/3) Alpha/beta hydrolase family
PF12544 (3/3) Lysine-2,3-aminomutase
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF00144 (3/3) Beta-lactamase
precursor_jaccard_groups_44771 16.20 +- 0.40 2 0 0 0 0.12 +- 0.09 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_7811 239.28 +- 91.90 4 0 0 0 0.03 +- 0.04 4 14

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF16259 (4/4) Domain of unknown function (DUF4913)
PF13535 (4/4) ATP-grasp domain
PF12307 (4/4) Protein of unknown function (DUF3631)
PF08239 (4/4) Bacterial SH3 domain
PF07690 (4/4) Major Facilitator Superfamily
PF03771 (4/4) Domain of unknown function (DUF317)
PF01638 (4/4) HxlR-like helix-turn-helix
PF00583 (4/4) Acetyltransferase (GNAT) family
PF01555 (3/4) DNA methylase
TIGR01167 (2/4) LPXTG cell wall anchor domain
PF17802 (2/4) Prealbumin-like fold domain
precursor_jaccard_groups_15134 64.68 +- 17.93 3 0 0 0 0.05 +- 0.03 3 5

TIGR00842 (3/3) transporter, betaine/carnitine/choline transporter (BCCT) family
PF02386 (3/3) Cation transport protein
PF02254 (3/3) TrkA-N domain
PF02080 (3/3) TrkA-C domain
PF02028 (3/3) BCCT, betaine/carnitine/choline family transporter
precursor_jaccard_groups_20493 10.29 +- 0.89 3 0 3 0 0.19 +- 0.39 3 6

TIGR00876 (3/3) transaldolase
PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF01590 (3/3) GAF domain
PF00923 (3/3) Transaldolase/Fructose-6-phosphate aldolase
precursor_jaccard_groups_26100 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_30004 407.43 +- 112.57 2 0 0 0 0.01 +- 0.00 2 4

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_3102 145.76 +- 73.63 7 0 0 0 0.20 +- 0.19 7 14

TIGR03860 (7/7) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (7/7) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF08445 (7/7) FR47-like protein
PF00528 (7/7) Binding-protein-dependent transport system inner membrane component
PF00497 (7/7) Bacterial extracellular solute-binding proteins, family 3
PF00296 (7/7) Luciferase-like monooxygenase
PF00005 (7/7) ABC transporter
PF01613 (6/7) Flavin reductase like domain
TIGR03558 (4/7) luciferase family oxidoreductase, group 1
PF13187 (4/7) 4Fe-4S dicluster domain
PF09084 (4/7) NMT1/THI5 like
PF02910 (4/7) Fumarate reductase flavoprotein C-term
PF02668 (4/7) Taurine catabolism dioxygenase TauD, TfdA family
PF00890 (4/7) FAD binding domain
precursor_jaccard_groups_30001 18.84 +- 0.27 2 0 1 0 0.21 +- 0.32 2 5

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF13631 (2/2) Cytochrome b(N-terminal)/b6/petB
PF03060 (2/2) Nitronate monooxygenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF02467 (2/2) Transcription factor WhiB
precursor_jaccard_groups_389 56.04 +- 29.53 58 0 0 0 0.15 +- 0.17 58 6

TIGR00996 (58/58) virulence factor Mce family protein
PF11887 (58/58) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (58/58) MlaD protein
PF02405 (58/58) Permease MlaE
PF00005 (58/58) ABC transporter
PF13406 (50/58) Transglycosylase SLT domain
precursor_jaccard_groups_43439 538.57 +- 241.43 2 0 2 0 0.01 +- 0.02 2 6

PF07969 (2/2) Amidohydrolase family
PF07859 (2/2) alpha/beta hydrolase fold
PF07729 (2/2) FCD domain
PF02126 (2/2) Phosphotriesterase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_6961 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_21343 245.78 +- 157.19 3 0 0 0 0.08 +- 0.16 3 22

TIGR01552 (3/3) prevent-host-death family protein
TIGR00663 (3/3) DNA polymerase III, beta subunit
PF08031 (3/3) Berberine and berberine like
PF07690 (3/3) Major Facilitator Superfamily
PF05016 (3/3) ParE toxin of type II toxin-antitoxin system, parDE
PF04073 (3/3) Aminoacyl-tRNA editing domain
PF02768 (3/3) DNA polymerase III beta subunit, C-terminal domain
PF02767 (3/3) DNA polymerase III beta subunit, central domain
PF02604 (3/3) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF02274 (3/3) Amidinotransferase
PF01565 (3/3) FAD binding domain
PF00712 (3/3) DNA polymerase III beta subunit, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
TIGR00348 (2/3) type I site-specific deoxyribonuclease, HsdR family
PF18766 (2/3) SWI2/SNF2 ATPase
PF13476 (2/3) AAA domain
PF13304 (2/3) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (2/3) HsdM N-terminal domain
PF11867 (2/3) Domain of unknown function (DUF3387)
PF04313 (2/3) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/3) N-6 DNA Methylase
PF01420 (2/3) Type I restriction modification DNA specificity domain
precursor_jaccard_groups_31511 84.21 +- 4.14 2 0 0 0 0.12 +- 0.30 2 8

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10805 201.36 +- 56.02 5 0 0 0 0.04 +- 0.03 5 5

PF07729 (5/5) FCD domain
PF07690 (5/5) Major Facilitator Superfamily
PF04191 (5/5) Phospholipid methyltransferase
PF01370 (5/5) NAD dependent epimerase/dehydratase family
PF00392 (5/5) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_10807 217.74 +- 45.15 4 0 3 4 0.01 +- 0.00 4 4

TIGR01444 (4/4) methyltransferase, FkbM family
PF05050 (4/4) Methyltransferase FkbM domain
PF04055 (4/4) Radical SAM superfamily
PF02310 (4/4) B12 binding domain
precursor_jaccard_groups_2677 25.76 +- 6.74 2 0 0 0 0.08 +- 0.11 2 4

PF14534 (2/2) Domain of unknown function (DUF4440)
PF08002 (2/2) Protein of unknown function (DUF1697)
PF05922 (2/2) Peptidase inhibitor I9
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_2826 261.95 +- 183.62 13 0 0 0 0.04 +- 0.04 13 8

TIGR01821 (13/13) 5-aminolevulinic acid synthase
PF07690 (13/13) Major Facilitator Superfamily
PF06224 (13/13) Winged helix DNA-binding domain
PF03466 (13/13) LysR substrate binding domain
PF01408 (13/13) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (13/13) Acetyltransferase (GNAT) family
PF00155 (13/13) Aminotransferase class I and II
PF00126 (13/13) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_40523 1165.50 +- 4.50 2 0 0 0 0.01 +- 0.00 2 16

PF17645 (2/2) Arylmalonate decarboxylase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13459 (2/2) 4Fe-4S single cluster domain
PF10589 (2/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (2/2) FCD domain
PF02900 (2/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01512 (2/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00866 (2/2) Ring hydroxylating beta subunit
PF00857 (2/2) Isochorismatase family
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00355 (2/2) Rieske [2Fe-2S] domain
precursor_jaccard_groups_43189 19.26 +- 0.00 2 0 0 0 0.10 +- 0.09 2 5

TIGR01085 (2/2) UDP-N-acetylmuramyl-tripeptide synthetase
PF08245 (2/2) Mur ligase middle domain
PF02875 (2/2) Mur ligase family, glutamate ligase domain
PF01225 (2/2) Mur ligase family, catalytic domain
PF00135 (2/2) Carboxylesterase family
precursor_jaccard_groups_40521 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_jaccard_groups_23443 78.41 +- 22.70 2 0 2 0 0.04 +- 0.05 2 6

PF17926 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14219 (2/2) Domain of unknown function (DUF4328)
PF13354 (2/2) Beta-lactamase enzyme family
PF08044 (2/2) Domain of unknown function (DUF1707)
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_34300 520.00 +- 0.00 2 0 0 0 0.02 +- 0.02 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF05853 (2/2) beta-keto acid cleavage enzyme
PF03737 (2/2) Aldolase/RraA
PF01145 (2/2) SPFH domain / Band 7 family
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_44205 348.30 +- 38.70 2 0 2 0 0.01 +- 0.00 2 3

PF06339 (2/2) Ectoine synthase
PF01425 (2/2) Amidase
PF00668 (2/2) Condensation domain
precursor_jaccard_groups_44970 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_23846 678.69 +- 611.31 2 0 0 0 0.08 +- 0.25 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00480 (2/2) ROK family
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3215 57.86 +- 12.51 2 0 0 0 0.09 +- 0.12 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF08892 (2/2) YqcI/YcgG family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00689 (2/2) Cation transporting ATPase, C-terminus
PF13377 (1/2) Periplasmic binding protein-like domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00122 (1/2) E1-E2 ATPase
precursor_jaccard_groups_24824 40.45 +- 19.08 2 0 0 0 0.10 +- 0.16 2 6

TIGR00157 (2/2) ribosome small subunit-dependent GTPase A
PF13649 (2/2) Methyltransferase domain
PF07592 (2/2) Rhodopirellula transposase DDE domain
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF03193 (2/2) RsgA GTPase
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_33947 108.44 +- 22.50 2 0 0 0 0.09 +- 0.14 2 8

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF00893 (2/2) Small Multidrug Resistance protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_40984 130.01 +- 0.90 2 0 0 0 0.09 +- 0.16 2 8

TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00589 (2/2) Phage integrase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_39304 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_42116 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_27149 18.29 +- 3.21 2 0 0 0 0.17 +- 0.18 2 10

TIGR01068 (2/2) thioredoxin
PF17755 (2/2) UvrA DNA-binding domain
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13359 (2/2) DDE superfamily endonuclease
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02148 (2/2) Zn-finger in ubiquitin-hydrolases and other protein
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_34942 302.08 +- 95.98 2 0 2 0 0.04 +- 0.02 2 11

PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF07730 (2/2) Histidine kinase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03936 (2/2) Terpene synthase family, metal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02401 (2/2) LytB protein
PF00348 (2/2) Polyprenyl synthetase
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF13683 (1/2) Integrase core domain
precursor_jaccard_groups_12706 1070.36 +- 277.93 4 0 0 0 0.02 +- 0.01 4 9

PF17914 (4/4) HopA1 effector protein family
PF13649 (4/4) Methyltransferase domain
PF12698 (4/4) ABC-2 family transporter protein
PF02441 (4/4) Flavoprotein
PF01636 (4/4) Phosphotransferase enzyme family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF13732 (3/4) Domain of unknown function (DUF4162)
PF00196 (3/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_31460 126.04 +- 6.73 2 0 0 0 0.13 +- 0.24 2 9

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11730 2101.96 +- 1163.07 4 0 4 0 0.04 +- 0.10 4 29

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (4/4) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (4/4) amino acid adenylation domain
TIGR01444 (4/4) methyltransferase, FkbM family
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07977 (4/4) FabA-like domain
PF05977 (4/4) Transmembrane secretion effector
PF05050 (4/4) Methyltransferase FkbM domain
PF03621 (4/4) MbtH-like protein
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF02729 (4/4) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01648 (4/4) 4'-phosphopantetheinyl transferase superfamily
PF01323 (4/4) DSBA-like thioredoxin domain
PF00975 (4/4) Thioesterase domain
PF00668 (4/4) Condensation domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00185 (4/4) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (4/4) Beta-lactamase
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_31665 396.67 +- 119.33 2 0 2 0 0.01 +- 0.00 2 8

TIGR00052 (2/2) nudix-type nucleoside diphosphatase, YffH/AdpP family
PF13855 (2/2) Leucine rich repeat
PF13516 (2/2) Leucine Rich repeat
PF07690 (2/2) Major Facilitator Superfamily
PF02641 (2/2) Uncharacterized ACR, COG1993
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_14078 150.50 +- 136.83 4 0 0 0 0.03 +- 0.02 4 3

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)
precursor_jaccard_groups_34163 209.75 +- 177.25 2 0 2 0 0.05 +- 0.04 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_5839 1450.71 +- 935.42 8 0 8 0 0.02 +- 0.06 8 13

PF13622 (8/8) Thioesterase-like superfamily
PF07690 (8/8) Major Facilitator Superfamily
PF00550 (8/8) Phosphopantetheine attachment site
PF00501 (8/8) AMP-binding enzyme
PF00487 (8/8) Fatty acid desaturase
PF00301 (8/8) Rubredoxin
PF00067 (8/8) Cytochrome P450
PF12679 (5/8) ABC-2 family transporter protein
PF00005 (5/8) ABC transporter
TIGR00711 (4/8) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF12697 (4/8) Alpha/beta hydrolase family
PF12146 (4/8) Serine aminopeptidase, S33
PF00392 (4/8) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_2274 63.58 +- 10.78 5 0 0 0 0.12 +- 0.21 5 5

PF17964 (5/5) Bacterial Ig domain
PF03734 (5/5) L,D-transpeptidase catalytic domain
PF02687 (5/5) FtsX-like permease family
PF00082 (5/5) Subtilase family
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_34549 24.48 +- 4.30 2 0 0 0 0.18 +- 0.22 2 10

PF04016 (2/2) Putative heavy-metal chelation
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00425 (2/2) chorismate binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter
TIGR00223 (1/2) aspartate 1-decarboxylase
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF02261 (1/2) Aspartate decarboxylase
precursor_jaccard_groups_2272 291.57 +- 235.66 16 0 16 0 0.05 +- 0.10 16 10

TIGR01821 (16/16) 5-aminolevulinic acid synthase
PF16884 (16/16) N-terminal domain of oxidoreductase
PF08545 (16/16) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (16/16) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (16/16) Major Facilitator Superfamily
PF02668 (16/16) Taurine catabolism dioxygenase TauD, TfdA family
PF00155 (16/16) Aminotransferase class I and II
PF00107 (16/16) Zinc-binding dehydrogenase
TIGR01891 (10/16) amidohydrolase
PF01546 (10/16) Peptidase family M20/M25/M40
precursor_jaccard_groups_23938 181.00 +- 77.00 2 0 0 0 0.01 +- 0.01 2 2

PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_4800 66.06 +- 37.25 9 0 0 0 0.06 +- 0.06 9 5

PF13563 (9/9) 2'-5' RNA ligase superfamily
PF07690 (9/9) Major Facilitator Superfamily
PF06831 (9/9) Formamidopyrimidine-DNA glycosylase H2TH domain
PF01243 (9/9) Pyridoxamine 5'-phosphate oxidase
PF01149 (9/9) Formamidopyrimidine-DNA glycosylase N-terminal domain
precursor_jaccard_groups_2070 42.25 +- 11.38 4 0 0 0 0.09 +- 0.09 4 14

TIGR03696 (4/4) RHS repeat-associated core domain
TIGR01643 (4/4) YD repeat (two copies)
PF05593 (4/4) RHS Repeat
PF13581 (2/4) Histidine kinase-like ATPase domain
PF13361 (2/4) UvrD-like helicase C-terminal domain
PF13245 (2/4) AAA domain
PF12833 (2/4) Helix-turn-helix domain
PF07690 (2/4) Major Facilitator Superfamily
PF05721 (2/4) Phytanoyl-CoA dioxygenase (PhyH)
PF04264 (2/4) YceI-like domain
PF03527 (2/4) RHS protein
PF00903 (2/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/4) Condensation domain
PF00069 (2/4) Protein kinase domain
precursor_jaccard_groups_40 193.98 +- 446.06 91 0 91 0 0.13 +- 0.26 91 8

PF00668 (91/91) Condensation domain
PF00550 (91/91) Phosphopantetheine attachment site
TIGR01733 (90/91) amino acid adenylation domain
PF13193 (90/91) AMP-binding enzyme C-terminal domain
PF00501 (90/91) AMP-binding enzyme
PF03621 (89/91) MbtH-like protein
PF00975 (54/91) Thioesterase domain
TIGR01720 (53/91) non-ribosomal peptide synthase domain TIGR01720
precursor_jaccard_groups_2073 542.61 +- 185.61 14 3 11 14 0.01 +- 0.01 11 7

TIGR03882 (14/14) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (14/14) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF02624 (14/14) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (14/14) Nitroreductase family
TIGR03605 (10/14) SagB-type dehydrogenase domain
precursor_jaccard_groups_45 47.38 +- 63.00 5 0 1 0 0.16 +- 0.25 5 3

PF13560 (5/5) Helix-turn-helix domain
PF04672 (5/5) S-adenosyl methyltransferase
PF04149 (5/5) Domain of unknown function (DUF397)
precursor_jaccard_groups_44 82.21 +- 168.14 137 0 3 0 0.18 +- 0.32 137 6

PF14029 (137/137) Protein of unknown function (DUF4244)
PF00482 (137/137) Type II secretion system (T2SS), protein F
PF00437 (102/137) Type II/IV secretion system protein
TIGR03819 (100/137) helicase/secretion neighborhood ATPase
TIGR03815 (100/137) helicase/secretion neighborhood CpaE-like protein
TIGR03816 (87/137) helicase/secretion neighborhood TadE-like protein
precursor_jaccard_groups_24624 54.83 +- 10.17 2 0 2 0 0.06 +- 0.03 2 4

PF13377 (2/2) Periplasmic binding protein-like domain
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05270 (2/2) Alpha-L-arabinofuranosidase B (ABFB) domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_48 11.23 +- 3.50 3 0 0 0 0.24 +- 0.40 3 2

PF02446 (3/3) 4-alpha-glucanotransferase
TIGR00217 (2/3) 4-alpha-glucanotransferase
precursor_jaccard_groups_35789 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_3072 258.23 +- 98.52 12 0 0 0 0.03 +- 0.03 12 15

PF17754 (12/12) MftR C-terminal domain
PF14525 (12/12) AraC-binding-like domain
PF12833 (12/12) Helix-turn-helix domain
PF08240 (12/12) Alcohol dehydrogenase GroES-like domain
PF04444 (12/12) Catechol dioxygenase N terminus
PF02776 (12/12) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (12/12) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (12/12) FAD binding domain
PF01425 (12/12) Amidase
PF01047 (12/12) MarR family
PF00775 (12/12) Dioxygenase
PF00465 (12/12) Iron-containing alcohol dehydrogenase
PF00205 (12/12) Thiamine pyrophosphate enzyme, central domain
PF00107 (12/12) Zinc-binding dehydrogenase
PF00106 (12/12) short chain dehydrogenase
precursor_jaccard_groups_10702 32.91 +- 17.84 5 0 5 5 0.13 +- 0.11 5 6

PF14518 (5/5) Iron-containing redox enzyme
PF13191 (5/5) AAA ATPase domain
PF13185 (5/5) GAF domain
PF04055 (5/5) Radical SAM superfamily
PF00211 (5/5) Adenylate and Guanylate cyclase catalytic domain
PF00082 (5/5) Subtilase family
precursor_jaccard_groups_31208 133.90 +- 28.60 2 0 0 0 0.06 +- 0.07 2 4

PF13309 (2/2) HTH domain
PF08348 (2/2) YheO-like PAS domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_31209 1272.69 +- 677.31 2 0 1 0 0.01 +- 0.01 2 10

PF01663 (2/2) Type I phosphodiesterase / nucleotide pyrophosphatase
PF01569 (2/2) PAP2 superfamily
PF01061 (2/2) ABC-2 type transporter
PF00550 (2/2) Phosphopantetheine attachment site
PF00005 (2/2) ABC transporter
TIGR01179 (1/2) UDP-glucose 4-epimerase GalE
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00534 (1/2) Glycosyl transferases group 1
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_848 179.29 +- 128.76 17 0 15 17 0.03 +- 0.03 17 3

PF00733 (17/17) Asparagine synthase
PF13302 (16/17) Acetyltransferase (GNAT) domain
PF13471 (15/17) Transglutaminase-like superfamily
precursor_jaccard_groups_23719 68.84 +- 20.47 2 0 0 0 0.05 +- 0.06 2 4

TIGR03382 (2/2) Myxococcales GC_trans_RRR domain
PF13285 (2/2) Domain of unknown function (DUF4073)
PF00353 (2/2) RTX calcium-binding nonapeptide repeat (4 copies)
PF00149 (2/2) Calcineurin-like phosphoesterase
precursor_jaccard_groups_13489 1036.41 +- 903.21 4 0 4 0 0.06 +- 0.21 4 24

TIGR03297 (4/4) phosphonopyruvate decarboxylase
TIGR02315 (4/4) phosphonate ABC transporter, ATP-binding protein
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR01098 (4/4) phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
TIGR01097 (4/4) phosphonate ABC transporter, permease protein PhnE
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF14765 (4/4) Polyketide synthase dehydratase
PF12974 (4/4) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01676 (4/4) Metalloenzyme superfamily
PF00698 (4/4) Acyl transferase domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00117 (4/4) Glutamine amidotransferase class-I
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF00106 (4/4) short chain dehydrogenase
PF00005 (4/4) ABC transporter
PF00550 (3/4) Phosphopantetheine attachment site
precursor_jaccard_groups_7309 145.17 +- 21.77 2 0 2 0 0.03 +- 0.04 2 9

TIGR03026 (2/2) nucleotide sugar dehydrogenase
PF13669 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13641 (2/2) Glycosyltransferase like family 2
PF13520 (2/2) Amino acid permease
PF13088 (2/2) BNR repeat-like domain
PF04237 (2/2) YjbR
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_26753 21.30 +- 0.66 2 0 0 0 0.09 +- 0.13 2 5

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_28919 51.79 +- 15.31 2 0 0 0 0.17 +- 0.20 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_42565 523.42 +- 54.35 2 0 2 2 0.05 +- 0.08 2 18

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13575 (2/2) Domain of unknown function (DUF4135)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00664 (2/2) ABC transporter transmembrane region
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07366 (1/2) SnoaL-like polyketide cyclase
precursor_jaccard_groups_7572 227.00 +- 56.01 4 0 4 0 0.01 +- 0.01 4 2

PF03301 (4/4) Tryptophan 2,3-dioxygenase
PF00891 (4/4) O-methyltransferase domain
precursor_jaccard_groups_12184 26.59 +- 10.34 2 0 0 0 0.23 +- 0.33 2 10

TIGR02094 (2/2) alpha-glucan phosphorylases
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF11897 (2/2) Protein of unknown function (DUF3417)
PF07730 (2/2) Histidine kinase
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00343 (2/2) Carbohydrate phosphorylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_42109 86.99 +- 43.01 2 0 0 0 0.05 +- 0.08 2 5

PF14078 (2/2) Domain of unknown function (DUF4259)
PF13649 (2/2) Methyltransferase domain
PF03780 (2/2) Asp23 family, cell envelope-related function
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF06902 (1/2) Divergent 4Fe-4S mono-cluster
precursor_jaccard_groups_7175 191.28 +- 79.56 6 0 6 6 0.07 +- 0.08 6 9

PF08386 (6/6) TAP-like protein
PF05532 (6/6) CsbD-like
PF05147 (6/6) Lanthionine synthetase C-like protein
PF00664 (6/6) ABC transporter transmembrane region
PF00561 (6/6) alpha/beta hydrolase fold
PF00069 (6/6) Protein kinase domain
PF00005 (6/6) ABC transporter
PF12697 (5/6) Alpha/beta hydrolase family
PF00117 (4/6) Glutamine amidotransferase class-I
precursor_jaccard_groups_2418 52.88 +- 8.23 2 0 0 0 0.06 +- 0.03 2 5

TIGR00589 (2/2) methylated-DNA--[protein]-cysteine S-methyltransferase
PF07690 (2/2) Major Facilitator Superfamily
PF03009 (2/2) Glycerophosphoryl diester phosphodiesterase family
PF02870 (2/2) 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
precursor_jaccard_groups_42104 520.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 2

PF13649 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
precursor_jaccard_groups_42102 140.32 +- 82.54 2 0 0 0 0.07 +- 0.19 2 12

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06684 (2/2) Amino acid synthesis
PF01361 (2/2) Tautomerase enzyme
PF00668 (2/2) Condensation domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_5834 11.85 +- 0.99 2 0 0 0 0.17 +- 0.17 2 5

PF16697 (2/2) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_41569 218.47 +- 168.53 2 0 0 2 0.03 +- 0.07 2 5

TIGR04053 (2/2) radical SAM protein, BA_1875 family
TIGR00562 (2/2) protoporphyrinogen oxidase
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01593 (2/2) Flavin containing amine oxidoreductase
precursor_jaccard_groups_18578 63.35 +- 11.31 3 0 0 0 0.05 +- 0.03 3 4

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_7308 351.61 +- 54.50 4 0 3 0 0.01 +- 0.00 4 5

TIGR01426 (4/4) glycosyltransferase, MGT family
PF02441 (4/4) Flavoprotein
PF01370 (4/4) NAD dependent epimerase/dehydratase family
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF03559 (2/4) NDP-hexose 2,3-dehydratase
precursor_jaccard_groups_12969 211.91 +- 0.82 2 0 0 0 0.03 +- 0.03 2 3

PF08241 (2/2) Methyltransferase domain
PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
precursor_jaccard_groups_38688 1632.40 +- 187.60 2 0 2 2 0.01 +- 0.00 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_11607 213.18 +- 122.47 4 0 0 0 0.01 +- 0.01 4 3

PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF01120 (4/4) Alpha-L-fucosidase
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
precursor_jaccard_groups_32647 381.16 +- 102.59 2 0 0 0 0.02 +- 0.02 2 4

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_32646 2340.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 11

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00202 (2/2) Aminotransferase class-III
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_14050 15.72 +- 2.87 3 0 0 0 0.20 +- 0.18 3 5

PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02057 (3/3) Glycosyl hydrolase family 59
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_42415 69.21 +- 27.54 2 0 0 0 0.07 +- 0.07 2 3

PF13489 (2/2) Methyltransferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1683 1113.46 +- 656.80 21 1 20 21 0.03 +- 0.11 20 8

TIGR03898 (21/21) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (21/21) type 2 lantibiotic biosynthesis protein LanM
PF13575 (21/21) Domain of unknown function (DUF4135)
PF05147 (21/21) Lanthionine synthetase C-like protein
PF03412 (21/21) Peptidase C39 family
PF00664 (21/21) ABC transporter transmembrane region
PF00005 (21/21) ABC transporter
PF12679 (17/21) ABC-2 family transporter protein
precursor_jaccard_groups_14256 333.46 +- 193.05 3 0 0 0 0.03 +- 0.01 3 6

PF14498 (3/3) Glycosyl hydrolase family 65, N-terminal domain
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF07994 (3/3) Myo-inositol-1-phosphate synthase
PF03664 (3/3) Glycosyl hydrolase family 62
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_31843 518.00 +- 2.00 2 0 0 0 0.01 +- 0.00 2 6

PF13469 (2/2) Sulfotransferase family
PF05977 (2/2) Transmembrane secretion effector
PF02274 (2/2) Amidinotransferase
PF02065 (2/2) Melibiase
PF01583 (2/2) Adenylylsulphate kinase
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_18714 147.46 +- 15.60 3 0 2 0 0.02 +- 0.01 3 6

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
PF02805 (3/3) Metal binding domain of Ada
PF01035 (3/3) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_15654 16.84 +- 1.44 2 0 0 0 0.18 +- 0.17 2 9

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF14525 (2/2) AraC-binding-like domain
PF14273 (2/2) Domain of unknown function (DUF4360)
PF12833 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
PF00089 (2/2) Trypsin
precursor_jaccard_groups_6792 293.75 +- 130.25 7 0 3 0 0.04 +- 0.16 7 7

TIGR01733 (7/7) amino acid adenylation domain
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF07690 (7/7) Major Facilitator Superfamily
PF00975 (7/7) Thioesterase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
precursor_jaccard_groups_3541 595.93 +- 375.41 11 0 11 0 0.03 +- 0.10 11 31

TIGR02087 (11/11) 3-isopropylmalate dehydratase, small subunit
TIGR01733 (11/11) amino acid adenylation domain
TIGR00566 (11/11) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (11/11) aminodeoxychorismate synthase, component I
PF16197 (11/11) Ketoacyl-synthetase C-terminal extension
PF14765 (11/11) Polyketide synthase dehydratase
PF13673 (11/11) Acetyltransferase (GNAT) domain
PF13649 (11/11) Methyltransferase domain
PF13480 (11/11) Acetyltransferase (GNAT) domain
PF13193 (11/11) AMP-binding enzyme C-terminal domain
PF08659 (11/11) KR domain
PF07690 (11/11) Major Facilitator Superfamily
PF04715 (11/11) Anthranilate synthase component I, N terminal region
PF02801 (11/11) Beta-ketoacyl synthase, C-terminal domain
PF01817 (11/11) Chorismate mutase type II
PF01474 (11/11) Class-II DAHP synthetase family
PF01063 (11/11) Amino-transferase class IV
PF00850 (11/11) Histone deacetylase domain
PF00698 (11/11) Acyl transferase domain
PF00694 (11/11) Aconitase C-terminal domain
PF00682 (11/11) HMGL-like
PF00668 (11/11) Condensation domain
PF00550 (11/11) Phosphopantetheine attachment site
PF00501 (11/11) AMP-binding enzyme
PF00425 (11/11) chorismate binding enzyme
PF00330 (11/11) Aconitase family (aconitate hydratase)
PF00180 (11/11) Isocitrate/isopropylmalate dehydrogenase
PF00117 (11/11) Glutamine amidotransferase class-I
PF00109 (11/11) Beta-ketoacyl synthase, N-terminal domain
PF05977 (10/11) Transmembrane secretion effector
PF00975 (10/11) Thioesterase domain
precursor_jaccard_groups_18375 12.06 +- 1.52 2 0 0 0 0.17 +- 0.21 2 2

PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_21950 18.93 +- 8.65 3 0 0 0 0.16 +- 0.10 3 5

PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02515 (3/3) CoA-transferase family III
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00248 (2/3) Aldo/keto reductase family
precursor_jaccard_groups_32791 194.25 +- 0.75 2 0 0 0 0.02 +- 0.01 2 2

PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35329 305.85 +- 81.15 2 0 0 0 0.03 +- 0.02 2 9

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF12724 (2/2) Flavodoxin domain
PF12679 (2/2) ABC-2 family transporter protein
PF08962 (2/2) Domain of unknown function (DUF1876)
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00690 (2/2) Cation transporter/ATPase, N-terminus
PF00689 (2/2) Cation transporting ATPase, C-terminus
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_742 89.73 +- 65.71 41 0 39 41 0.04 +- 0.02 41 3

PF13471 (41/41) Transglutaminase-like superfamily
PF05402 (41/41) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (41/41) Asparagine synthase
precursor_jaccard_groups_37103 174.15 +- 19.35 2 0 2 0 0.02 +- 0.01 2 6

TIGR03026 (2/2) nucleotide sugar dehydrogenase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_jaccard_groups_32794 130.62 +- 30.62 2 0 0 2 0.04 +- 0.07 2 5

PF13560 (2/2) Helix-turn-helix domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF04055 (2/2) Radical SAM superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF12840 (1/2) Helix-turn-helix domain
precursor_jaccard_groups_23150 454.71 +- 299.58 3 0 1 0 0.06 +- 0.12 3 18

PF17677 (3/3) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF09261 (3/3) Alpha mannosidase middle domain
PF07748 (3/3) Glycosyl hydrolases family 38 C-terminal domain
PF06283 (3/3) Trehalose utilisation
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01074 (3/3) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
PF13412 (2/3) Winged helix-turn-helix DNA-binding
PF12840 (2/3) Helix-turn-helix domain
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/3) Acyl transferase domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00480 (2/3) ROK family
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_5950 5344.50 +- 176.64 4 0 4 4 0.01 +- 0.00 4 15

TIGR04267 (4/4) HEXXH motif domain
TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF14907 (4/4) Uncharacterised nucleotidyltransferase
PF13714 (4/4) Phosphoenolpyruvate phosphomutase
PF13640 (4/4) 2OG-Fe(II) oxygenase superfamily
PF08241 (4/4) Methyltransferase domain
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02585 (4/4) GlcNAc-PI de-N-acetylase
PF02223 (4/4) Thymidylate kinase
PF02195 (4/4) ParB-like nuclease domain
PF01909 (4/4) Nucleotidyltransferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00293 (4/4) NUDIX domain
PF00202 (4/4) Aminotransferase class-III
precursor_jaccard_groups_8861 66.79 +- 9.92 2 0 0 0 0.20 +- 0.21 2 20

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01373 (2/2) sarcosine oxidase, beta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
TIGR01186 (2/2) glycine betaine/L-proline transport ATP binding subunit
PF17806 (2/2) Sarcosine oxidase A3 domain
PF16350 (2/2) FAD dependent oxidoreductase central domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF04069 (2/2) Substrate binding domain of ABC-type glycine betaine transport system
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF00809 (1/2) Pterin binding enzyme
precursor_jaccard_groups_43963 234.51 +- 98.07 2 0 2 0 0.08 +- 0.05 2 17

TIGR03494 (2/2) salicylate synthase
TIGR01761 (2/2) thiazolinyl imide reductase
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF13649 (2/2) Methyltransferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08242 (2/2) Methyltransferase domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10019 186.69 +- 106.02 5 0 0 5 0.05 +- 0.05 5 7

TIGR00778 (5/5) alkylhydroperoxidase AhpD family core domain
PF13714 (5/5) Phosphoenolpyruvate phosphomutase
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF04237 (5/5) YjbR
PF02627 (5/5) Carboxymuconolactone decarboxylase family
PF00881 (5/5) Nitroreductase family
PF00107 (5/5) Zinc-binding dehydrogenase
precursor_jaccard_groups_38657 98.53 +- 15.34 2 0 2 2 0.20 +- 0.16 2 15

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF14019 (2/2) Protein of unknown function (DUF4235)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02909 (2/2) Tetracyclin repressor-like, C-terminal domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_33685 11.06 +- 0.00 2 0 2 0 0.18 +- 0.04 2 2

PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_19532 356.00 +- 31.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF17645 (2/2) Arylmalonate decarboxylase
PF07690 (2/2) Major Facilitator Superfamily
PF01361 (2/2) Tautomerase enzyme
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_27389 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_jaccard_groups_22400 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_27922 16.02 +- 0.10 2 0 0 0 0.12 +- 0.08 2 4

TIGR01695 (2/2) murein biosynthesis integral membrane protein MurJ
PF03023 (2/2) Lipid II flippase MurJ
PF01810 (2/2) LysE type translocator
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_19027 292.40 +- 51.60 2 0 0 0 0.03 +- 0.04 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_37144 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
precursor_jaccard_groups_38499 126.13 +- 80.27 2 0 2 2 0.11 +- 0.23 2 17

TIGR01374 (2/2) sarcosine oxidase, delta subunit family
TIGR01372 (2/2) sarcosine oxidase, alpha subunit family
PF17806 (2/2) Sarcosine oxidase A3 domain
PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13471 (2/2) Transglutaminase-like superfamily
PF08669 (2/2) Glycine cleavage T-protein C-terminal barrel domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04268 (2/2) Sarcosine oxidase, gamma subunit family
PF04267 (2/2) Sarcosine oxidase, delta subunit family
PF01571 (2/2) Aminomethyltransferase folate-binding domain
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR01373 (1/2) sarcosine oxidase, beta subunit family
PF01266 (1/2) FAD dependent oxidoreductase
PF00464 (1/2) Serine hydroxymethyltransferase
precursor_jaccard_groups_37140 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_jaccard_groups_19155 23.19 +- 7.53 3 0 0 0 0.19 +- 0.33 3 12

TIGR02103 (3/3) alpha-1,6-glucosidases, pullulanase-type
PF17967 (3/3) Pullulanase N2 domain
PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF11852 (3/3) Domain of unknown function (DUF3372)
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF03714 (3/3) Bacterial pullanase-associated domain
PF02962 (3/3) 5-carboxymethyl-2-hydroxymuconate isomerase
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02057 (3/3) Glycosyl hydrolase family 59
PF00128 (3/3) Alpha amylase, catalytic domain
PF00072 (3/3) Response regulator receiver domain
precursor_jaccard_groups_19156 325.00 +- 65.00 2 0 0 0 0.01 +- 0.00 2 1

PF08007 (2/2) Cupin superfamily protein
precursor_jaccard_groups_1205 32.96 +- 13.69 27 0 26 0 0.15 +- 0.19 27 9

PF03450 (27/27) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (27/27) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (27/27) [2Fe-2S] binding domain
PF01315 (27/27) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (27/27) FAD binding domain in molybdopterin dehydrogenase
PF00111 (27/27) 2Fe-2S iron-sulfur cluster binding domain
PF09856 (15/27) Predicted transcriptional regulator (DUF2083)
PF06114 (15/27) IrrE N-terminal-like domain
PF01381 (15/27) Helix-turn-helix
precursor_jaccard_groups_13618 1513.29 +- 1279.53 4 0 1 0 0.02 +- 0.02 4 14

TIGR00217 (4/4) 4-alpha-glucanotransferase
PF13692 (4/4) Glycosyl transferases group 1
PF08323 (4/4) Starch synthase catalytic domain
PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF07883 (4/4) Cupin domain
PF06182 (4/4) ABC-2 family transporter protein
PF04321 (4/4) RmlD substrate binding domain
PF02446 (4/4) 4-alpha-glucanotransferase
PF01761 (4/4) 3-dehydroquinate synthase
PF00483 (4/4) Nucleotidyl transferase
PF00480 (4/4) ROK family
PF00202 (4/4) Aminotransferase class-III
PF00005 (4/4) ABC transporter
PF01636 (3/4) Phosphotransferase enzyme family
precursor_jaccard_groups_36091 137.60 +- 34.40 2 0 0 0 0.02 +- 0.01 2 3

PF13401 (2/2) AAA domain
PF08808 (2/2) RES domain
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_41245 127.29 +- 23.67 2 0 2 0 0.04 +- 0.06 2 8

PF13564 (2/2) DoxX-like family
PF12680 (2/2) SnoaL-like domain
PF08843 (2/2) Nucleotidyl transferase AbiEii toxin, Type IV TA system
PF06441 (2/2) Epoxide hydrolase N terminus
PF03413 (2/2) Peptidase propeptide and YPEB domain
PF01810 (2/2) LysE type translocator
PF00561 (2/2) alpha/beta hydrolase fold
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_844 391.60 +- 199.55 36 0 36 0 0.04 +- 0.10 36 18

TIGR01733 (36/36) amino acid adenylation domain
PF13193 (36/36) AMP-binding enzyme C-terminal domain
PF07690 (36/36) Major Facilitator Superfamily
PF06224 (36/36) Winged helix DNA-binding domain
PF03621 (36/36) MbtH-like protein
PF00668 (36/36) Condensation domain
PF00550 (36/36) Phosphopantetheine attachment site
PF00501 (36/36) AMP-binding enzyme
PF00067 (36/36) Cytochrome P450
PF00975 (35/36) Thioesterase domain
PF00171 (35/36) Aldehyde dehydrogenase family
PF03704 (34/36) Bacterial transcriptional activator domain
PF00486 (34/36) Transcriptional regulatory protein, C terminal
PF02771 (32/36) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (32/36) Acyl-CoA dehydrogenase, middle domain
PF00441 (32/36) Acyl-CoA dehydrogenase, C-terminal domain
PF01648 (31/36) 4'-phosphopantetheinyl transferase superfamily
PF13649 (19/36) Methyltransferase domain
precursor_jaccard_groups_845 14.95 +- 2.90 9 0 0 0 0.19 +- 0.16 9 6

PF13378 (9/9) Enolase C-terminal domain-like
PF02746 (9/9) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00294 (9/9) pfkB family carbohydrate kinase
TIGR02605 (7/9) putative regulatory protein, FmdB family
PF14325 (7/9) Domain of unknown function (DUF4383)
PF09723 (7/9) Zinc ribbon domain
precursor_jaccard_groups_14812 53.97 +- 3.94 4 0 0 0 0.19 +- 0.07 4 8

PF14310 (4/4) Fibronectin type III-like domain
PF13377 (4/4) Periplasmic binding protein-like domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_29805 57.99 +- 0.06 2 0 2 0 0.09 +- 0.06 2 13

TIGR02159 (2/2) phenylacetate-CoA oxygenase, PaaJ subunit
TIGR02158 (2/2) phenylacetate-CoA oxygenase, PaaI subunit
TIGR02157 (2/2) phenylacetate-CoA oxygenase, PaaH subunit
TIGR02156 (2/2) phenylacetate-CoA oxygenase, PaaG subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF06243 (2/2) Phenylacetic acid degradation B
PF05138 (2/2) Phenylacetic acid catabolic protein
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF01883 (2/2) Iron-sulfur cluster assembly protein
PF00970 (2/2) Oxidoreductase FAD-binding domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
Halogenase 459.41 +- 759.04 78 0 69 5 0.10 +- 0.22 78 10

PF04820 (78/78) Tryptophan halogenase
PF00550 (53/78) Phosphopantetheine attachment site
PF00999 (49/78) Sodium/hydrogen exchanger family
PF00975 (48/78) Thioesterase domain
PF00501 (47/78) AMP-binding enzyme
PF13193 (45/78) AMP-binding enzyme C-terminal domain
PF00005 (44/78) ABC transporter
PF00196 (40/78) Bacterial regulatory proteins, luxR family
PF00664 (39/78) ABC transporter transmembrane region
PF00067 (39/78) Cytochrome P450
Acyltransferases 270.63 +- 462.89 2119 0 844 221 0.08 +- 0.17 2119

No common domains found
Transferring Alkyl or Aryl Groups Other than Methyl Groups 308.09 +- 485.77 390 0 262 10 0.09 +- 0.19 390

No common domains found
Glycosyltransferases 352.18 +- 611.31 518 0 232 80 0.08 +- 0.19 518

No common domains found
Transferring Aldehyde or Ketonic Groups 510.79 +- 689.09 117 0 52 2 0.06 +- 0.18 117 2

PF00456 (100/117) Transketolase, thiamine diphosphate binding domain
PF02779 (95/117) Transketolase, pyrimidine binding domain
Transferring One-Carbon Groups 424.52 +- 790.13 1388 0 604 293 0.07 +- 0.17 1388

No common domains found
Transferring Phosphorus-Containing Groups 276.60 +- 618.57 2348 0 893 234 0.11 +- 0.23 2348

No common domains found
Transferring Sulfur-Containing Groups 237.67 +- 272.01 65 0 23 9 0.10 +- 0.17 65 1

PF01144 (48/65) Coenzyme A transferase
Transferring Nitrogenous Groups 654.80 +- 955.44 706 0 404 142 0.06 +- 0.15 706 1

PF00202 (405/706) Aminotransferase class-III
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
Streptomyces hygroscopicus subsp. hygroscopicus 134.35 +- 125.08 19 0 3 2 0.09 +- 0.21 19

No common domains found
Streptomyces albidoflavus 80.33 +- 75.18 5 0 2 3 0.13 +- 0.14 5 1

PF02624 (3/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
Streptomyces lydicus 232.92 +- 387.08 22 0 6 5 0.09 +- 0.17 22

No common domains found
Streptomyces sp. 1114.5 159.20 +- 235.65 35 0 13 4 0.09 +- 0.22 35

No common domains found
Streptomyces sp. NRRL S-384 388.76 +- 853.94 11 0 5 4 0.11 +- 0.21 11

No common domains found
Streptomyces albidoflavus 169.57 +- 183.77 9 0 3 4 0.09 +- 0.16 9

No common domains found
Streptomyces amritsarensis 234.88 +- 251.90 12 0 4 1 0.10 +- 0.26 12

No common domains found
Streptomyces sp. ms115 269.06 +- 475.74 14 0 3 3 0.11 +- 0.14 14

No common domains found
Streptomyces sp. NRRL S-495 293.70 +- 360.76 17 0 3 1 0.05 +- 0.15 17

No common domains found
Streptomyces antibioticus 315.44 +- 469.70 19 0 3 2 0.08 +- 0.19 19

No common domains found
Streptomyces pactum 195.76 +- 345.11 19 0 10 1 0.08 +- 0.15 19

No common domains found
Streptomyces sp. st170 97.22 +- 128.48 10 0 3 1 0.10 +- 0.09 10

No common domains found
Streptomyces albovinaceus 123.01 +- 166.39 10 0 3 2 0.10 +- 0.14 10

No common domains found
Streptomyces clavuligerus 488.56 +- 438.22 22 0 11 2 0.05 +- 0.15 22

No common domains found
Streptomyces chartreusis NRRL 3882 67.75 +- 72.58 16 0 4 2 0.14 +- 0.12 16

No common domains found
Streptomyces purpureus KA281 119.31 +- 153.01 9 0 4 1 0.09 +- 0.12 9

No common domains found
Streptomyces griseus subsp. rhodochrous 139.40 +- 202.73 19 0 6 5 0.11 +- 0.24 19

No common domains found
Streptomyces albidoflavus 87.28 +- 72.03 9 0 3 4 0.16 +- 0.17 9

No common domains found
[Kitasatospora] papulosa 77.00 +- 99.58 16 0 6 2 0.14 +- 0.22 16

No common domains found
Streptomyces sp. WAC 01438 414.30 +- 476.03 16 0 3 1 0.08 +- 0.14 16

No common domains found
Streptomyces sp. WM6378 299.92 +- 438.26 25 0 7 3 0.08 +- 0.18 25

No common domains found
Streptomyces sp. B27 105.61 +- 113.98 17 0 8 5 0.13 +- 0.22 17

No common domains found
Streptomyces thermolilacinus SPC6 153.38 +- 178.10 8 0 2 2 0.14 +- 0.25 8

No common domains found
Streptomyces hirsutus 512.93 +- 529.69 13 0 4 1 0.07 +- 0.15 13

No common domains found
Streptomyces sp. NTK 937 370.25 +- 455.97 8 0 2 1 0.05 +- 0.17 8

No common domains found
Streptomyces sp. KPB2 140.01 +- 231.37 10 0 2 0 0.11 +- 0.18 10

No common domains found
Streptomyces sp. LaPpAH-108 379.51 +- 552.53 11 0 4 2 0.08 +- 0.19 11

No common domains found
Streptomyces sp. NRRL WC-3742 267.21 +- 323.64 27 0 7 2 0.07 +- 0.17 27

No common domains found
Streptomyces sp. MMG1533 302.07 +- 513.81 34 0 7 0 0.09 +- 0.18 34

No common domains found
Streptomyces sp. CB02366 153.57 +- 190.00 13 0 3 1 0.07 +- 0.13 13

No common domains found
Streptomyces katrae 198.23 +- 120.26 3 0 0 1 0.10 +- 0.11 3

No common domains found
Streptomyces griseochromogenes 376.04 +- 553.99 26 0 11 7 0.09 +- 0.21 26

No common domains found
Streptomyces fradiae 392.42 +- 651.65 19 0 10 3 0.05 +- 0.14 19

No common domains found
Streptomyces rimosus subsp. rimosus ATCC 10970 320.03 +- 681.22 21 0 8 3 0.07 +- 0.15 21

No common domains found
Streptomyces sp. WAC05374 105.27 +- 130.93 7 0 3 1 0.12 +- 0.22 7

No common domains found
Streptomyces sp. 3211.1 493.16 +- 1059.06 17 0 8 6 0.04 +- 0.10 17

No common domains found
Streptomyces sp. ADI93-02 139.72 +- 192.82 19 0 2 1 0.11 +- 0.20 19

No common domains found
Streptomyces sp. Ru87 229.39 +- 259.42 6 0 0 1 0.08 +- 0.14 6

No common domains found
Streptomyces capuensis 274.65 +- 499.45 17 0 7 3 0.08 +- 0.15 17

No common domains found
Streptomyces sp. 3211.6 450.59 +- 528.15 12 0 6 3 0.05 +- 0.11 12

No common domains found
Streptomyces albulus 81.96 +- 46.57 10 0 2 1 0.10 +- 0.19 10

No common domains found
Streptomyces griseus subsp. griseus 138.64 +- 133.90 14 0 7 5 0.12 +- 0.17 14

No common domains found
Streptomyces sp. CNQ865 209.85 +- 266.97 18 0 4 0 0.09 +- 0.18 18

No common domains found
Streptomyces sp. CB03578 593.94 +- 726.71 14 0 5 5 0.04 +- 0.08 14

No common domains found
Streptomyces lividans 1326 158.68 +- 285.89 11 0 4 2 0.15 +- 0.15 11

No common domains found
Streptomyces luteocolor 510.51 +- 983.64 22 0 12 2 0.07 +- 0.18 22

No common domains found
Streptomyces niveus 377.41 +- 547.25 15 0 4 2 0.05 +- 0.10 15

No common domains found
Streptomyces sp. CB03234 289.50 +- 416.94 16 0 8 3 0.10 +- 0.21 16

No common domains found
Streptomyces sp. KE1 98.88 +- 68.73 10 0 5 3 0.10 +- 0.14 10

No common domains found
Streptomyces avermitilis MA-4680 = NBRC 14893 192.68 +- 230.71 30 0 12 2 0.07 +- 0.12 30

No common domains found
Streptomyces scabiei 128.96 +- 99.24 7 0 1 1 0.06 +- 0.09 7

No common domains found
Streptomyces sp. NRRL F-5727 608.38 +- 1656.50 15 0 6 5 0.09 +- 0.18 15

No common domains found
Streptomyces griseofuscus 258.18 +- 408.55 15 0 5 2 0.08 +- 0.13 15

No common domains found
Streptomyces sp. AVP053U2 267.46 +- 360.39 20 0 5 2 0.09 +- 0.17 20

No common domains found
Streptomyces sp. WM4235 271.77 +- 231.15 12 0 3 1 0.08 +- 0.19 12

No common domains found
Streptomyces olivaceus 102.14 +- 77.66 19 0 8 1 0.14 +- 0.21 19

No common domains found
Streptomyces parvulus 51.61 +- 54.57 8 0 3 1 0.15 +- 0.17 8

No common domains found
Streptomyces sp. NEAU-LD23 236.26 +- 242.21 30 0 7 3 0.08 +- 0.19 30

No common domains found
Streptomyces sp. NEAU-D10 185.33 +- 270.45 22 0 6 2 0.08 +- 0.15 22

No common domains found
Streptomyces sp. CB03911 429.16 +- 537.27 23 0 11 2 0.07 +- 0.17 23

No common domains found
Streptomyces sp. Sge12 192.46 +- 194.04 15 0 10 0 0.11 +- 0.23 15

No common domains found
Streptomyces sp. NBRC 109706 588.78 +- 618.80 22 0 7 2 0.05 +- 0.15 22

No common domains found
Streptomyces sp. CNQ431 279.18 +- 345.44 18 0 10 5 0.08 +- 0.16 18

No common domains found
Streptomyces sp. SA15 142.11 +- 149.39 24 0 4 1 0.10 +- 0.19 24

No common domains found
Streptomyces ambofaciens 139.43 +- 168.46 8 0 2 1 0.14 +- 0.22 8

No common domains found
Streptomyces pini 98.99 +- 104.76 10 0 4 4 0.12 +- 0.14 10

No common domains found
Streptomyces mediolani 150.96 +- 203.54 17 0 4 5 0.10 +- 0.14 17

No common domains found
Streptomyces sp. FxanaA7 139.53 +- 126.51 21 0 6 2 0.09 +- 0.16 21

No common domains found
Streptomyces sp. Root431 431.60 +- 479.98 12 0 1 3 0.08 +- 0.22 12

No common domains found
Streptomyces sp. 5112.2 474.57 +- 538.83 14 0 10 3 0.09 +- 0.18 14

No common domains found
Streptomyces albidoflavus 113.43 +- 134.59 11 0 4 4 0.11 +- 0.19 11

No common domains found
Streptomyces sp. WAC 00631 89.64 +- 70.52 8 0 2 1 0.12 +- 0.16 8

No common domains found
Streptomyces lavendulae subsp. lavendulae 250.93 +- 648.07 23 0 9 5 0.10 +- 0.20 23

No common domains found
Streptomyces sp. Root1319 169.91 +- 168.15 13 0 2 1 0.10 +- 0.19 13

No common domains found
Streptomyces sp. SM18 243.52 +- 356.56 16 0 6 1 0.09 +- 0.19 16

No common domains found
Streptomyces rimosus subsp. rimosus 292.79 +- 629.89 25 0 9 5 0.08 +- 0.18 25

No common domains found
Streptomyces sp. CS131 233.49 +- 268.83 13 0 6 4 0.12 +- 0.21 13

No common domains found
Streptomyces corchorusii 288.32 +- 302.76 24 0 9 2 0.09 +- 0.20 24

No common domains found
Streptomyces sp. CS147 251.08 +- 257.80 11 0 4 4 0.10 +- 0.16 11

No common domains found
Streptomyces scabiei 123.25 +- 108.99 7 0 0 0 0.05 +- 0.06 7

No common domains found
Streptomyces sp. SPMA113 191.57 +- 183.46 34 0 10 2 0.10 +- 0.19 34

No common domains found
Streptomyces sp. NRRL WC-3719 230.15 +- 212.95 3 0 2 2 0.10 +- 0.12 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. HPH0547 102.74 +- 87.78 8 0 4 3 0.06 +- 0.12 8

No common domains found
Streptomyces fulvissimus DSM 40593 125.03 +- 147.07 12 0 8 0 0.13 +- 0.20 12

No common domains found
Streptomyces albulus 371.59 +- 383.55 26 0 13 5 0.05 +- 0.13 26

No common domains found
Streptomyces sp. CS081A 249.77 +- 272.79 13 0 5 1 0.09 +- 0.19 13

No common domains found
Streptomyces sp. Ag82_O1-9 208.47 +- 378.07 25 0 5 2 0.10 +- 0.15 25

No common domains found
Streptomyces sp. MMG1522 71.12 +- 49.21 12 0 3 4 0.12 +- 0.18 12

No common domains found
Streptomyces sp. San01 157.01 +- 155.50 23 0 0 1 0.07 +- 0.15 23

No common domains found
Streptomyces sp. Z26 235.46 +- 258.21 16 0 7 4 0.06 +- 0.18 16

No common domains found
Streptomyces sp. AmelKG-E11A 405.20 +- 664.52 20 0 10 4 0.09 +- 0.20 20

No common domains found
Streptomyces sp. NBRC 110030 203.10 +- 253.89 12 0 3 0 0.10 +- 0.17 12

No common domains found
Streptomyces sp. PRh5 416.27 +- 937.91 34 0 9 4 0.07 +- 0.15 34

No common domains found
Streptomyces mangrovisoli 669.59 +- 1614.35 8 0 1 1 0.13 +- 0.19 8 1

PF00392 (4/8) Bacterial regulatory proteins, gntR family
Streptomyces fimicarius 139.81 +- 159.52 7 0 1 3 0.08 +- 0.10 7

No common domains found
Streptomyces sp. XY58 154.47 +- 170.43 11 0 5 0 0.12 +- 0.22 11

No common domains found
Streptomyces sp. 74 97.24 +- 98.02 32 0 7 2 0.12 +- 0.17 32

No common domains found
Streptomyces thermovulgaris 350.81 +- 499.25 7 0 3 1 0.07 +- 0.16 7

No common domains found
Streptomyces sp. P3 735.60 +- 1490.73 31 0 9 4 0.06 +- 0.13 31

No common domains found
Streptomyces sp. DvalAA-83 280.15 +- 276.40 8 0 3 0 0.08 +- 0.18 8

No common domains found
Streptomyces africanus 200.88 +- 243.66 15 0 3 1 0.08 +- 0.12 15

No common domains found
Streptomyces sp. CNY243 290.32 +- 333.56 22 0 5 1 0.08 +- 0.19 22

No common domains found
Streptomyces sp. UNC401CLCol 53.61 +- 40.26 3 0 1 1 0.13 +- 0.12 3

No common domains found
Streptomyces avicenniae 320.08 +- 629.60 12 0 3 3 0.08 +- 0.19 12

No common domains found
Streptomyces paucisporeus 192.96 +- 269.75 12 0 5 1 0.09 +- 0.19 12

No common domains found
Streptomyces capuensis 142.60 +- 286.29 20 0 9 4 0.11 +- 0.18 20

No common domains found
Streptomyces sp. MP131-18 161.00 +- 189.54 14 0 5 1 0.12 +- 0.23 14

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 245.74 +- 277.47 27 0 5 2 0.08 +- 0.20 27

No common domains found
Streptomyces sp. NRRL WC-3795 119.90 +- 163.79 12 0 4 0 0.09 +- 0.19 12

No common domains found
Streptomyces lavendulae subsp. lavendulae 940.54 +- 1090.16 19 0 7 0 0.03 +- 0.12 19

No common domains found
Streptomyces sp. XY37 141.07 +- 160.24 13 0 6 1 0.12 +- 0.21 13

No common domains found
Streptomyces turgidiscabies 163.56 +- 228.64 32 0 6 2 0.10 +- 0.18 32

No common domains found
Streptomyces sp. PanSC9 110.60 +- 109.76 9 0 2 1 0.16 +- 0.19 9

No common domains found
Streptomyces prasinopilosus 73.31 +- 44.87 2 0 1 0 0.14 +- 0.19 2 13

TIGR01733 (1/2) amino acid adenylation domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF14681 (1/2) Uracil phosphoribosyltransferase
PF14029 (1/2) Protein of unknown function (DUF4244)
PF14027 (1/2) Questin oxidase-like
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF07811 (1/2) TadE-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF04227 (1/2) Indigoidine synthase A like protein
PF00975 (1/2) Thioesterase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00482 (1/2) Type II secretion system (T2SS), protein F
Streptomyces noursei ATCC 11455 474.40 +- 871.12 35 0 16 6 0.06 +- 0.13 35

No common domains found
Streptomyces sp. SCSIO 03032 220.40 +- 188.55 14 0 7 5 0.12 +- 0.24 14

No common domains found
Streptomyces sp. CNS606 201.64 +- 303.77 11 0 4 1 0.08 +- 0.18 11

No common domains found
Streptomyces europaeiscabiei 176.24 +- 301.00 18 0 1 0 0.08 +- 0.13 18

No common domains found
Streptomyces sp. NWU49 344.17 +- 490.29 17 0 4 1 0.07 +- 0.17 17

No common domains found
Streptomyces sp. WAC05950 155.02 +- 98.43 8 0 5 0 0.07 +- 0.16 8 1

PF00067 (4/8) Cytochrome P450
Streptomyces sp. CB02130 186.20 +- 253.42 24 0 7 4 0.10 +- 0.16 24

No common domains found
Streptomyces sp. WAC06614 143.10 +- 168.11 7 0 1 1 0.11 +- 0.24 7

No common domains found
Streptomyces stelliscabiei 248.81 +- 319.57 15 0 4 0 0.05 +- 0.06 15

No common domains found
Streptomyces sp. 19 221.47 +- 194.25 7 0 3 2 0.12 +- 0.11 7

No common domains found
Streptomyces sp. NRRL S-378 279.95 +- 294.54 14 0 6 1 0.05 +- 0.13 14

No common domains found
Streptomyces sp. Cmuel-A718b 239.55 +- 262.34 13 0 4 3 0.12 +- 0.20 13

No common domains found
Streptomyces albidoflavus 77.77 +- 59.49 9 0 2 4 0.13 +- 0.14 9

No common domains found
Streptomyces sp. SAI-097 163.23 +- 250.24 12 0 5 0 0.13 +- 0.19 12

No common domains found
Streptomyces sp. ICC4 216.25 +- 195.36 19 0 4 1 0.08 +- 0.19 19

No common domains found
Streptomyces ambofaciens ATCC 23877 644.68 +- 1412.60 12 0 2 1 0.13 +- 0.23 12

No common domains found
Streptomyces reticuliscabiei 254.98 +- 239.92 30 0 6 1 0.06 +- 0.13 30

No common domains found
Streptomyces sp. OK228 266.26 +- 476.58 34 0 7 4 0.08 +- 0.13 34

No common domains found
Streptomyces rimosus subsp. rimosus 184.38 +- 306.94 18 0 7 5 0.09 +- 0.14 18

No common domains found
Streptomyces albidoflavus 198.32 +- 221.96 10 0 5 4 0.14 +- 0.18 10 1

PF00005 (6/10) ABC transporter
Streptomyces sp. 59 157.03 +- 167.36 29 0 6 2 0.10 +- 0.17 29

No common domains found
Streptomyces sp. MBT28 125.58 +- 163.96 9 0 3 0 0.14 +- 0.22 9

No common domains found
Streptomyces niveus 91.33 +- 122.51 14 0 5 1 0.15 +- 0.19 14

No common domains found
Streptomyces sp. b62 591.84 +- 809.62 14 0 4 4 0.08 +- 0.21 14

No common domains found
Streptomyces sp. NRRL F-5555 30.43 +- 21.10 8 0 1 0 0.18 +- 0.22 8

No common domains found
Streptomyces melanosporofaciens 526.32 +- 1043.78 29 0 6 1 0.09 +- 0.19 29

No common domains found
Streptomyces sp. MnatMP-M27 286.99 +- 321.42 14 0 3 2 0.06 +- 0.13 14

No common domains found
Streptomyces sp. TAA040 344.35 +- 366.51 5 0 1 1 0.06 +- 0.10 5

No common domains found
Streptomyces sp. CB09001 260.79 +- 381.70 14 0 5 1 0.08 +- 0.18 14

No common domains found
Streptomyces filamentosus NRRL 11379 128.18 +- 207.45 9 0 5 3 0.15 +- 0.14 9

No common domains found
Streptomyces yokosukanensis 237.37 +- 372.58 15 0 6 1 0.08 +- 0.11 15

No common domains found
Streptomyces acidiscabies 256.16 +- 262.33 32 0 7 1 0.08 +- 0.20 32

No common domains found
Streptomyces puniciscabiei 399.24 +- 677.93 14 0 2 3 0.08 +- 0.11 14

No common domains found
Streptomyces autolyticus 191.29 +- 262.52 24 0 7 4 0.11 +- 0.21 24

No common domains found
Streptomyces albidoflavus 121.36 +- 80.67 8 0 4 4 0.14 +- 0.15 8 1

PF00005 (5/8) ABC transporter
Streptomyces fradiae ATCC 10745 = DSM 40063 183.53 +- 185.98 5 0 2 2 0.11 +- 0.23 5

No common domains found
Streptomyces sp. NRRL B-1322 115.32 +- 76.71 11 0 8 1 0.09 +- 0.19 11

No common domains found
Streptomyces barkulensis 149.46 +- 196.21 9 0 7 3 0.10 +- 0.21 9

No common domains found
Streptomyces sp. Ncost-T6T-1 287.18 +- 390.64 12 0 2 2 0.11 +- 0.19 12

No common domains found
Streptomyces triticagri 363.74 +- 470.06 9 0 2 0 0.10 +- 0.17 9

No common domains found
Streptomyces sp. 4121.5 307.63 +- 390.10 24 0 10 5 0.07 +- 0.18 24

No common domains found
Streptomyces violaceoruber 256.41 +- 485.41 32 0 5 1 0.09 +- 0.19 32

No common domains found
Streptomyces sp. CS014 413.83 +- 724.33 21 0 9 4 0.08 +- 0.19 21

No common domains found
Streptomyces scabiei 190.79 +- 332.20 13 0 0 0 0.06 +- 0.10 13

No common domains found
Streptomyces rimosus subsp. pseudoverticillatus 640.37 +- 1243.40 23 0 10 6 0.06 +- 0.16 23

No common domains found
Streptomyces scabiei 343.40 +- 515.69 35 0 12 2 0.06 +- 0.13 35

No common domains found
Streptomyces rimosus subsp. rimosus 275.79 +- 593.96 19 0 9 4 0.09 +- 0.19 19

No common domains found
Streptomyces purpeochromogenes 104.81 +- 75.07 17 0 5 5 0.11 +- 0.19 17

No common domains found
Streptomyces griseorubens 97.27 +- 89.70 8 0 2 1 0.10 +- 0.14 8

No common domains found
Streptomyces sp. NRRL F-2799 124.39 +- 149.37 7 0 3 2 0.12 +- 0.12 7

No common domains found
Streptomyces aquilus 284.92 +- 651.72 24 0 7 1 0.10 +- 0.15 24

No common domains found
Streptomyces sp. ZFG47 317.35 +- 352.33 30 0 7 4 0.07 +- 0.15 30

No common domains found
Streptomyces sp. NRRL F-5650 568.29 +- 1148.92 13 0 3 1 0.06 +- 0.11 13

No common domains found
Streptomyces sp. ADI97-07 76.68 +- 69.08 13 0 4 1 0.15 +- 0.19 13

No common domains found
Streptomyces sp. 2233.5 140.05 +- 154.53 15 0 7 4 0.09 +- 0.18 15

No common domains found
Streptomyces sp. DconLS 346.29 +- 307.07 17 0 7 3 0.06 +- 0.17 17

No common domains found
Streptomyces resistomycificus 266.88 +- 312.01 17 0 4 1 0.08 +- 0.15 17

No common domains found
Streptomyces sp. CS149 156.17 +- 303.03 16 0 6 4 0.10 +- 0.16 16

No common domains found
Streptomyces fragilis 244.08 +- 246.27 8 0 5 1 0.08 +- 0.13 8

No common domains found
Streptomyces sp. XY431 182.46 +- 210.15 16 0 4 3 0.09 +- 0.21 16

No common domains found
Streptomyces albidoflavus 81.67 +- 69.86 7 0 2 3 0.15 +- 0.14 7

No common domains found
Streptomyces sp. NWU339 264.55 +- 497.25 19 0 4 1 0.10 +- 0.21 19

No common domains found
Streptomyces sp. M1013 111.89 +- 129.82 13 0 3 0 0.13 +- 0.22 13

No common domains found
Streptomyces scabiei 337.47 +- 538.17 26 0 8 0 0.07 +- 0.14 26

No common domains found
Streptomyces sp. ADI98-10 238.44 +- 392.72 15 0 5 4 0.10 +- 0.17 15

No common domains found
Streptomyces griseus subsp. griseus 74.66 +- 78.85 15 0 5 5 0.13 +- 0.22 15

No common domains found
Streptomyces sp. ms184 254.59 +- 417.31 11 0 0 0 0.09 +- 0.18 11

No common domains found
Streptomyces sp. 2314.4 452.32 +- 587.81 28 0 15 6 0.06 +- 0.16 28

No common domains found
Streptomyces specialis 234.17 +- 298.04 13 0 3 4 0.07 +- 0.18 13

No common domains found
Streptomyces sp. WAC01280 591.08 +- 856.95 23 0 5 5 0.05 +- 0.15 23

No common domains found
Streptomyces rimosus subsp. rimosus 146.58 +- 181.69 32 0 0 5 0.09 +- 0.18 32

No common domains found
Streptomyces lavendulae subsp. lavendulae 155.17 +- 262.03 13 0 4 1 0.11 +- 0.18 13

No common domains found
Streptomyces sp. XY533 153.59 +- 123.03 17 0 8 3 0.07 +- 0.15 17

No common domains found
Streptomyces luridiscabiei 116.87 +- 168.42 15 0 7 1 0.11 +- 0.19 15

No common domains found
Streptomyces scabiei 115.74 +- 94.85 11 0 1 0 0.07 +- 0.08 11

No common domains found
Streptomyces sp. NRRL S-1824 215.61 +- 207.11 27 0 3 0 0.09 +- 0.18 27

No common domains found
Streptomyces antibioticus 173.03 +- 203.51 21 0 3 2 0.12 +- 0.24 21

No common domains found
Streptomyces sp. NRRL F-2305 108.27 +- 124.75 9 0 3 1 0.09 +- 0.13 9

No common domains found
Streptomyces peucetius subsp. caesius ATCC 27952 280.73 +- 373.75 14 0 6 1 0.08 +- 0.17 14

No common domains found
Streptomyces sp. CC0208 374.60 +- 761.14 26 0 6 2 0.07 +- 0.11 26

No common domains found
Streptomyces sp. ETH9427 204.74 +- 341.30 15 0 2 3 0.08 +- 0.11 15

No common domains found
Streptomyces achromogenes subsp. achromogenes 821.19 +- 1861.04 10 0 2 1 0.07 +- 0.14 10

No common domains found
Streptomyces sp. WZ.A104 289.55 +- 287.22 16 0 6 1 0.07 +- 0.15 16

No common domains found
Streptomyces rubidus 146.49 +- 126.55 17 0 2 1 0.08 +- 0.13 17

No common domains found
Streptomyces sp. ADI96-15 149.93 +- 110.28 20 0 9 4 0.08 +- 0.19 20

No common domains found
Streptomyces sp. MnatMP-M17 699.45 +- 1466.91 7 0 3 2 0.09 +- 0.21 7

No common domains found
Streptomyces sp. BK022 1350.89 +- 1997.79 8 0 3 4 0.06 +- 0.13 8

No common domains found
Streptomyces griseorubiginosus 152.89 +- 140.74 18 0 3 2 0.09 +- 0.16 18

No common domains found
Streptomyces scopuliridis RB72 313.25 +- 351.11 14 0 5 0 0.10 +- 0.22 14

No common domains found
Streptomyces alboflavus 367.69 +- 376.52 18 0 9 3 0.03 +- 0.08 18

No common domains found
Streptomyces violaceusniger 220.72 +- 358.75 27 0 6 1 0.08 +- 0.14 27

No common domains found
Streptomyces rimosus subsp. rimosus 91.93 +- 80.08 17 0 4 1 0.12 +- 0.18 17

No common domains found
Streptomyces sp. XY332 115.24 +- 199.23 14 0 6 0 0.13 +- 0.23 14

No common domains found
Streptomyces geranii 189.76 +- 203.72 35 0 4 0 0.07 +- 0.11 35

No common domains found
Streptomyces sp. NP10 268.99 +- 399.43 15 0 5 4 0.11 +- 0.17 15

No common domains found
Streptomyces sp. JHA26 625.58 +- 1129.05 5 0 2 0 0.09 +- 0.18 5 1

PF00005 (3/5) ABC transporter
Streptomyces sp. NRRL S-623 122.63 +- 136.47 27 0 14 2 0.11 +- 0.19 27

No common domains found
Streptomyces griseofuscus 205.54 +- 292.03 18 0 13 5 0.09 +- 0.20 18

No common domains found
Streptomyces sp. Ru73 107.55 +- 155.19 17 0 2 2 0.10 +- 0.20 17

No common domains found
Streptomyces lavendulae subsp. lavendulae 163.39 +- 290.35 21 0 7 5 0.09 +- 0.14 21

No common domains found
Streptomyces sp. Ag109_O5-10 105.52 +- 80.77 19 0 3 1 0.12 +- 0.23 19

No common domains found
Streptomyces ossamyceticus 152.73 +- 180.44 18 0 5 0 0.09 +- 0.15 18

No common domains found
Streptomyces katrae 188.15 +- 317.02 15 0 5 1 0.10 +- 0.18 15

No common domains found
Streptomyces sp. NRRL WC-3605 164.14 +- 228.31 10 0 1 0 0.11 +- 0.19 10

No common domains found
Streptomyces cinnamoneus 399.68 +- 813.38 15 0 9 3 0.07 +- 0.19 15

No common domains found
Streptomyces sp. 844.5 314.40 +- 730.86 34 0 8 4 0.10 +- 0.22 34

No common domains found
Streptomyces albireticuli 265.33 +- 291.71 25 0 15 2 0.08 +- 0.20 25

No common domains found
Streptomyces albidoflavus 104.58 +- 91.95 9 0 5 3 0.12 +- 0.16 9

No common domains found
Streptomyces sp. Ru71 200.48 +- 214.34 13 0 3 0 0.11 +- 0.19 13

No common domains found
Streptomyces viridochromogenes 357.08 +- 372.18 32 0 3 2 0.05 +- 0.11 32

No common domains found
Streptomyces lushanensis 365.65 +- 398.30 12 0 2 3 0.05 +- 0.11 12

No common domains found
Streptomyces sp. CNT318 203.41 +- 234.90 14 0 8 4 0.06 +- 0.15 14

No common domains found
Streptomyces anulatus 177.94 +- 202.11 20 0 9 4 0.08 +- 0.16 20

No common domains found
Streptomyces sp. CB01580 173.11 +- 302.67 24 0 9 3 0.10 +- 0.18 24

No common domains found
Streptomyces sp. NRRL F-6131 284.52 +- 331.85 24 0 7 2 0.06 +- 0.14 24

No common domains found
Streptomyces sp. 76 148.02 +- 167.09 21 0 5 3 0.11 +- 0.21 21

No common domains found
Streptomyces acidiscabies 172.76 +- 303.61 20 0 2 1 0.09 +- 0.17 20

No common domains found
Streptomyces sp. NRRL WC-3604 279.70 +- 337.80 18 0 2 0 0.09 +- 0.19 18

No common domains found
Streptomyces olivochromogenes 185.46 +- 222.54 30 0 7 3 0.09 +- 0.18 30

No common domains found
Streptomyces neyagawaensis 88.82 +- 79.50 13 0 1 0 0.12 +- 0.18 13

No common domains found
Streptomyces sp. st140 257.98 +- 352.81 12 0 3 3 0.11 +- 0.10 12

No common domains found
Streptomyces californicus 107.72 +- 84.35 17 0 5 5 0.10 +- 0.19 17

No common domains found
Streptomyces sp. gb14 364.36 +- 382.71 8 0 4 4 0.07 +- 0.08 8 1

PF00005 (4/8) ABC transporter
Streptomyces sp. sk226 245.87 +- 399.44 8 0 2 1 0.06 +- 0.09 8

No common domains found
Streptomyces murinus 356.65 +- 52.57 4 0 1 1 0.02 +- 0.05 4 1

PF07690 (2/4) Major Facilitator Superfamily
Streptomyces albidoflavus 305.76 +- 588.92 7 0 3 3 0.07 +- 0.10 7

No common domains found
Streptomyces sp. SM14 257.28 +- 387.75 5 0 1 1 0.09 +- 0.11 5

No common domains found
Streptomyces rimosus subsp. rimosus 256.45 +- 662.34 22 0 9 5 0.11 +- 0.20 22

No common domains found
Streptomyces sp. CNS654 260.28 +- 460.14 19 0 5 4 0.12 +- 0.22 19

No common domains found
Streptomyces novaecaesareae 576.04 +- 991.04 18 0 7 3 0.06 +- 0.15 18

No common domains found
Streptomyces sp. V2 116.25 +- 121.19 16 0 1 2 0.13 +- 0.23 16

No common domains found
Streptomyces sp. ERV7 92.00 +- 98.54 8 0 1 1 0.12 +- 0.16 8

No common domains found
Streptomyces sp. f51 146.75 +- 128.84 14 0 5 4 0.11 +- 0.15 14

No common domains found
Streptomyces sp. NRRL F-5193 143.14 +- 109.72 14 0 4 1 0.12 +- 0.19 14

No common domains found
Streptomyces albus 332.48 +- 582.06 17 0 9 5 0.08 +- 0.18 17

No common domains found
Streptomyces sp. JHA19 209.91 +- 152.28 12 0 0 0 0.07 +- 0.11 12

No common domains found
Streptomyces resistomycificus 325.30 +- 425.11 23 0 6 0 0.07 +- 0.14 23

No common domains found
Streptomyces rimosus subsp. rimosus 199.00 +- 309.47 21 0 8 5 0.10 +- 0.19 21

No common domains found
Streptomyces hygroscopicus subsp. limoneus 165.31 +- 244.61 17 0 6 2 0.09 +- 0.18 17

No common domains found
Streptomyces globisporus C-1027 124.49 +- 131.63 14 0 4 4 0.12 +- 0.14 14

No common domains found
Streptomyces bobili 206.39 +- 244.16 9 0 3 0 0.07 +- 0.16 9

No common domains found
Streptomyces phaeoluteigriseus 183.36 +- 225.79 18 0 5 1 0.08 +- 0.18 18

No common domains found
Streptomyces sp. WAC00469 110.64 +- 79.72 9 0 4 3 0.10 +- 0.13 9

No common domains found
Streptomyces diastaticus subsp. ardesiacus 74.10 +- 83.15 12 0 2 0 0.14 +- 0.16 12

No common domains found
Streptomyces agglomeratus 525.78 +- 856.20 19 0 8 4 0.06 +- 0.12 19

No common domains found
Streptomyces mutomycini 332.59 +- 592.97 10 0 3 1 0.09 +- 0.17 10

No common domains found
Streptomyces exfoliatus DSM 41693 306.56 +- 549.30 12 0 2 1 0.07 +- 0.17 12

No common domains found
Streptomyces sp. Root55 135.17 +- 122.01 22 0 4 1 0.12 +- 0.18 22

No common domains found
Streptomyces sp. 2131.1 780.23 +- 610.04 5 0 2 2 0.05 +- 0.15 5

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 187.71 +- 180.55 33 0 5 2 0.09 +- 0.19 33

No common domains found
Streptomyces sp. b84 222.75 +- 406.78 13 0 5 3 0.12 +- 0.15 13

No common domains found
Streptomyces sp. AA4 280.08 +- 463.25 22 0 6 1 0.11 +- 0.24 22

No common domains found
Streptomyces sp. SceaMP-e96 499.59 +- 1266.47 30 0 15 7 0.08 +- 0.18 30

No common domains found
Streptomyces sp. SPB78 25.77 +- 20.07 5 0 2 0 0.20 +- 0.31 5

No common domains found
Streptomyces sp. cf386 277.86 +- 361.17 41 0 6 3 0.07 +- 0.12 41

No common domains found
Streptomyces albidoflavus 168.85 +- 180.67 9 0 2 1 0.06 +- 0.08 9

No common domains found
Streptomyces diastatochromogenes 120.26 +- 115.52 34 0 10 2 0.12 +- 0.22 34

No common domains found
Streptomyces sp. CNT302 778.19 +- 1384.08 17 0 6 2 0.06 +- 0.16 17

No common domains found
Streptomyces venezuelae 164.02 +- 146.74 16 0 6 4 0.08 +- 0.18 16

No common domains found
Streptomyces sp. DI166 434.70 +- 576.42 18 0 8 8 0.08 +- 0.18 18

No common domains found
Streptomyces agglomeratus 488.41 +- 951.21 15 0 7 2 0.08 +- 0.14 15

No common domains found
Streptomyces sp. NRRL S-244 218.40 +- 274.74 18 0 5 2 0.08 +- 0.17 18

No common domains found
Streptomyces venezuelae 164.02 +- 146.74 16 0 6 4 0.08 +- 0.18 16

No common domains found
Streptomyces sp. NRRL S-146 108.10 +- 161.56 9 0 0 0 0.12 +- 0.17 9

No common domains found
Streptomyces sp. 351MFTsu5.1 138.91 +- 213.18 17 0 0 1 0.10 +- 0.14 17

No common domains found
Streptomyces sp. 2323.1 283.57 +- 341.90 25 0 11 6 0.07 +- 0.17 25

No common domains found
Streptomyces sp. e14 221.79 +- 248.70 12 0 2 0 0.03 +- 0.04 12

No common domains found
Streptomyces albidoflavus 212.47 +- 224.97 11 0 4 2 0.09 +- 0.19 11

No common domains found
Streptomyces sp. PTY087I2 258.14 +- 477.67 17 0 6 5 0.15 +- 0.23 17

No common domains found
Streptomyces sp. TSRI0107 313.30 +- 355.85 8 0 3 5 0.10 +- 0.21 8

No common domains found
Streptomyces albulus ZPM 382.05 +- 453.04 25 0 12 2 0.05 +- 0.11 25

No common domains found
Streptomyces sp. alain-838 606.35 +- 1236.68 12 0 1 1 0.05 +- 0.14 12

No common domains found
Streptomyces sp. yr375 448.80 +- 761.42 17 0 6 2 0.09 +- 0.20 17

No common domains found
Streptomyces dengpaensis 150.60 +- 178.52 19 0 3 1 0.10 +- 0.16 19

No common domains found
Streptomyces sp. NRRL S-920 259.54 +- 392.78 21 0 8 1 0.09 +- 0.16 21

No common domains found
Streptomyces sp. RP5T 679.59 +- 1655.78 15 0 1 1 0.08 +- 0.12 15

No common domains found
Streptomyces globisporus subsp. globisporus 386.13 +- 628.21 28 0 3 0 0.11 +- 0.22 28

No common domains found
Streptomyces sp. Ag82_O1-15 175.33 +- 190.62 34 0 5 3 0.09 +- 0.18 34

No common domains found
Streptomyces roseochromogenus subsp. oscitans DS 12.976 226.71 +- 285.70 24 0 6 2 0.09 +- 0.20 24

No common domains found
Streptomyces sp. SM9 310.00 +- 210.00 2 0 0 0 0.03 +- 0.02 2 7

TIGR01733 (1/2) amino acid adenylation domain
PF13649 (1/2) Methyltransferase domain
PF13280 (1/2) WYL domain
PF07859 (1/2) alpha/beta hydrolase fold
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00501 (1/2) AMP-binding enzyme
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
Streptomyces sp. PVA 94-07 75.77 +- 45.42 9 0 8 2 0.10 +- 0.19 9

No common domains found
Streptomyces sp. LamerLS-31b 361.51 +- 402.78 20 0 10 3 0.04 +- 0.11 20

No common domains found
Streptomyces sp. SS07 186.36 +- 286.22 15 0 4 3 0.08 +- 0.13 15

No common domains found
Streptomyces sp. NRRL F-3213 164.04 +- 273.41 37 0 9 3 0.10 +- 0.22 37

No common domains found
Streptomyces sp. NRRL S-1448 178.04 +- 195.81 22 0 7 2 0.09 +- 0.19 22

No common domains found
Streptomyces stelliscabiei 360.61 +- 680.70 25 0 6 0 0.08 +- 0.15 25

No common domains found
Streptomyces radiopugnans 144.47 +- 129.87 10 0 6 2 0.11 +- 0.17 10

No common domains found
Streptomyces hokutonensis 318.56 +- 429.30 38 0 4 1 0.07 +- 0.15 38

No common domains found
Streptomyces thermoautotrophicus 171.91 +- 175.59 12 0 0 0 0.09 +- 0.21 12

No common domains found
Streptomyces purpeochromogenes 239.17 +- 290.04 21 0 7 5 0.08 +- 0.18 21

No common domains found
Streptomyces toyocaensis 242.59 +- 264.76 7 0 1 2 0.12 +- 0.17 7

No common domains found
Streptomyces albidoflavus 85.06 +- 129.99 13 0 4 4 0.13 +- 0.15 13

No common domains found
Streptomyces virginiae 150.10 +- 153.28 18 0 8 2 0.10 +- 0.19 18

No common domains found
Streptomyces sp. TSRI0395 112.31 +- 119.48 17 0 4 4 0.14 +- 0.19 17

No common domains found
Streptomyces pactum 195.20 +- 257.24 9 0 5 1 0.10 +- 0.15 9

No common domains found
Streptomyces albidoflavus 82.16 +- 83.53 11 0 4 4 0.16 +- 0.15 11

No common domains found
Streptomyces sp. 2112.2 275.73 +- 349.33 25 0 9 6 0.09 +- 0.19 25

No common domains found
Streptomyces sp. Amel2xC10 317.44 +- 585.79 7 0 2 2 0.15 +- 0.26 7

No common domains found
Streptomyces griseofuscus 323.13 +- 395.16 15 0 4 1 0.04 +- 0.09 15

No common domains found
Streptomyces sp. NRRL F-6492 240.24 +- 235.58 11 0 1 1 0.07 +- 0.16 11

No common domains found
Streptomyces sp. 11-1-2 326.66 +- 523.06 37 0 10 2 0.07 +- 0.14 37

No common domains found
Streptomyces sp. f150 203.32 +- 336.18 18 0 4 3 0.12 +- 0.19 18

No common domains found
Streptomyces sp. TLI_146 381.85 +- 574.65 16 0 3 3 0.08 +- 0.16 16

No common domains found
Streptomyces subrutilus 233.68 +- 280.33 11 0 5 1 0.11 +- 0.22 11

No common domains found
Streptomyces sp. NRRL F-2747 283.19 +- 194.86 15 0 6 7 0.04 +- 0.09 15

No common domains found
Streptomyces sp. Go-475 127.46 +- 121.24 11 0 4 0 0.12 +- 0.20 11

No common domains found
Streptomyces sp. NRRL B-5680 395.16 +- 937.95 28 0 11 5 0.08 +- 0.18 28

No common domains found
Streptomyces sp. CLI2509 397.16 +- 736.11 7 0 3 0 0.06 +- 0.16 7

No common domains found
Streptomyces sp. or20 112.65 +- 104.98 19 0 7 2 0.11 +- 0.17 19

No common domains found
Streptomyces sp. Ncost-T10-10d 94.47 +- 97.75 20 0 3 2 0.12 +- 0.18 20

No common domains found
Streptomyces sp. NBRC 110465 168.49 +- 269.07 17 0 6 4 0.12 +- 0.22 17

No common domains found
Streptomyces sp. L-9-10 534.91 +- 1175.50 12 0 3 2 0.09 +- 0.13 12

No common domains found
Streptomyces viridosporus ATCC 14672 329.75 +- 470.24 13 0 4 0 0.06 +- 0.15 13

No common domains found
Streptomyces koyangensis 311.55 +- 407.30 13 0 6 0 0.08 +- 0.16 13

No common domains found
Streptomyces oceani 155.01 +- 166.82 14 0 4 0 0.11 +- 0.21 14

No common domains found
Streptomyces davaonensis JCM 4913 411.24 +- 460.56 25 0 5 2 0.07 +- 0.14 25

No common domains found
Streptomyces yanglinensis 294.34 +- 290.27 23 0 10 3 0.06 +- 0.14 23

No common domains found
Streptomyces canus 102.79 +- 103.65 7 0 1 0 0.14 +- 0.19 7

No common domains found
Streptomyces sp. 2224.1 145.68 +- 174.41 18 0 8 5 0.10 +- 0.18 18

No common domains found
Streptomyces yunnanensis 299.50 +- 547.38 25 0 11 3 0.05 +- 0.14 25

No common domains found
Streptomyces reticuli TUE45 306.54 +- 344.16 8 0 4 2 0.08 +- 0.19 8

No common domains found
Streptomyces sp. CNY228 218.86 +- 264.41 12 0 3 4 0.10 +- 0.19 12

No common domains found
Streptomyces phaeochromogenes 182.38 +- 266.16 25 0 3 2 0.08 +- 0.16 25

No common domains found
Streptomyces albidoflavus 83.23 +- 65.30 10 0 4 3 0.15 +- 0.18 10

No common domains found
Streptomyces griseolus 316.39 +- 525.49 11 0 1 1 0.11 +- 0.19 11

No common domains found
Streptomyces sp. WM6373 306.37 +- 437.76 18 0 9 3 0.09 +- 0.18 18

No common domains found
Streptomyces sp. ICBB 8177 227.16 +- 190.83 13 0 4 3 0.07 +- 0.16 13

No common domains found
Streptomyces sp. HNS054 104.89 +- 90.50 12 0 2 2 0.12 +- 0.18 12

No common domains found
Streptomyces sp. b94 150.78 +- 209.30 14 0 0 3 0.11 +- 0.21 14

No common domains found
Streptomyces sp. S5 286.22 +- 381.85 4 0 0 0 0.11 +- 0.19 4 4

PF13400 (2/4) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/4) TadE-like protein
PF00482 (2/4) Type II secretion system (T2SS), protein F
PF00437 (2/4) Type II/IV secretion system protein
Streptomyces odonnellii 228.79 +- 242.35 16 0 5 1 0.06 +- 0.15 16

No common domains found
Streptomyces albus subsp. albus 186.11 +- 139.25 12 0 6 4 0.07 +- 0.20 12

No common domains found
Streptomyces alni 592.81 +- 829.41 13 0 6 2 0.07 +- 0.12 13

No common domains found
Streptomyces scabiei 244.48 +- 451.72 20 0 3 1 0.10 +- 0.20 20

No common domains found
Streptomyces sp. FXJ7.023 98.02 +- 107.47 13 0 6 1 0.13 +- 0.23 13

No common domains found
Streptomyces triticirhizae 176.02 +- 130.10 8 0 3 1 0.10 +- 0.19 8

No common domains found
Streptomyces sp. A244 271.87 +- 658.91 17 0 9 3 0.10 +- 0.21 17

No common domains found
Streptomyces hyaluromycini 311.82 +- 533.89 42 0 10 4 0.08 +- 0.14 42

No common domains found
Streptomyces sp. 769 359.47 +- 1216.69 34 0 12 3 0.09 +- 0.19 34

No common domains found
Streptomyces sp. WAC07061 965.14 +- 1529.65 9 0 5 2 0.04 +- 0.14 9

No common domains found
Streptomyces harbinensis 178.14 +- 164.74 10 0 2 2 0.09 +- 0.20 10

No common domains found
Streptomyces sp. NRRL B-24051 141.67 +- 183.67 19 0 6 2 0.12 +- 0.19 19

No common domains found
Streptomyces clavuligerus 319.27 +- 328.60 17 0 12 2 0.08 +- 0.20 17

No common domains found
Streptomyces halstedii 108.55 +- 70.44 6 0 0 1 0.08 +- 0.17 6

No common domains found
Streptomyces alfalfae 388.41 +- 851.95 15 0 9 4 0.08 +- 0.18 15

No common domains found
Streptomyces sp. CC53 238.31 +- 268.25 6 0 3 2 0.07 +- 0.16 6

No common domains found
Streptomyces sp. LcepLS 99.92 +- 81.49 2 0 1 0 0.07 +- 0.11 2 6

PF13508 (1/2) Acetyltransferase (GNAT) domain
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF00664 (1/2) ABC transporter transmembrane region
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces orinoci 135.41 +- 153.16 9 0 3 1 0.09 +- 0.17 9

No common domains found
Streptomyces iranensis 337.93 +- 390.79 35 0 6 1 0.08 +- 0.16 35

No common domains found
Streptomyces sp. E2N171 130.34 +- 81.59 7 0 1 1 0.10 +- 0.17 7

No common domains found
Streptomyces aureocirculatus 292.40 +- 512.38 24 0 9 5 0.11 +- 0.23 24

No common domains found
Streptomyces acidiscabies 84-104 284.45 +- 304.02 38 0 10 1 0.07 +- 0.17 38

No common domains found
Streptomyces sp. cf124 258.03 +- 400.43 28 0 8 3 0.08 +- 0.19 28

No common domains found
Streptomyces klenkii 340.65 +- 488.89 13 0 7 2 0.09 +- 0.24 13

No common domains found
Streptomyces sp. AC1-42W 399.16 +- 493.31 19 0 8 6 0.06 +- 0.16 19

No common domains found
Streptomyces varsoviensis 560.04 +- 600.08 26 0 16 9 0.04 +- 0.15 26

No common domains found
Streptomyces venezuelae ATCC 10712 301.14 +- 365.42 19 0 6 3 0.08 +- 0.18 19

No common domains found
Streptomyces sp. Mg1 460.48 +- 440.63 9 0 4 3 0.05 +- 0.14 9

No common domains found
Streptomyces chartreusis 155.10 +- 198.55 36 0 9 6 0.11 +- 0.19 36

No common domains found
Streptomyces sp. LaPpAH-165 326.11 +- 406.09 16 0 5 2 0.11 +- 0.22 16

No common domains found
Streptomyces sp. S1 243.22 +- 311.03 18 0 3 2 0.09 +- 0.18 18

No common domains found
Streptomyces sp. Ru62 289.38 +- 578.23 21 0 5 1 0.08 +- 0.19 21

No common domains found
Streptomyces rimosus subsp. rimosus 153.74 +- 283.91 21 0 9 4 0.11 +- 0.18 21

No common domains found
Streptomyces albidoflavus 75.22 +- 85.57 10 0 3 4 0.16 +- 0.16 10

No common domains found
Streptomyces avermitilis MA-4680 = NBRC 14893 181.88 +- 176.79 16 0 8 2 0.09 +- 0.09 16

No common domains found
Streptomyces sp. WMMB 714 152.17 +- 187.96 14 0 7 1 0.09 +- 0.19 14 1

PF00005 (7/14) ABC transporter
Streptomyces rimosus subsp. rimosus 189.69 +- 454.75 23 0 11 6 0.11 +- 0.17 23

No common domains found
Streptomyces carminius 202.93 +- 220.67 10 0 3 2 0.09 +- 0.16 10

No common domains found
Streptomyces natalensis ATCC 27448 393.49 +- 611.62 31 0 11 2 0.07 +- 0.18 31

No common domains found
Streptomyces sp. XY66 402.90 +- 560.08 17 0 7 3 0.06 +- 0.14 17

No common domains found
Streptomyces filamentosus NRRL 15998 168.04 +- 221.73 7 0 4 3 0.13 +- 0.14 7

No common domains found
Streptomyces noursei 352.19 +- 451.37 33 0 17 4 0.05 +- 0.15 33

No common domains found
Streptomyces cattleya NRRL 8057 = DSM 46488 299.01 +- 403.49 16 0 7 2 0.10 +- 0.21 16

No common domains found
Streptomyces sp. CS159 204.16 +- 338.03 6 0 1 0 0.10 +- 0.18 6 1

PF07690 (3/6) Major Facilitator Superfamily
Streptomyces sp. Ag109_G2-1 606.17 +- 1056.44 13 0 8 2 0.04 +- 0.10 13

No common domains found
Streptomyces scabiei 233.76 +- 224.34 24 0 5 0 0.07 +- 0.13 24

No common domains found
Streptomyces sp. PsTaAH-137 187.89 +- 257.41 12 0 2 1 0.07 +- 0.16 12

No common domains found
Streptomyces sp. NRRL F-4711 27.70 +- 19.50 3 0 1 0 0.20 +- 0.20 3

No common domains found
Streptomyces sp. FBKL.4005 119.26 +- 103.81 9 0 6 3 0.11 +- 0.21 9 1

PF07690 (5/9) Major Facilitator Superfamily
Streptomyces shenzhenensis 482.26 +- 718.69 34 0 3 1 0.08 +- 0.19 34

No common domains found
Streptomyces sp. CB02120-2 335.35 +- 306.48 13 0 4 5 0.05 +- 0.09 13

No common domains found
Streptomyces sp. Tue6028 217.29 +- 280.13 15 0 2 2 0.10 +- 0.18 15

No common domains found
Streptomyces sp. CB00455 516.46 +- 777.00 8 0 4 1 0.09 +- 0.24 8

No common domains found
Streptomyces sp. MNU77 185.56 +- 350.78 23 0 7 5 0.10 +- 0.18 23

No common domains found
Streptomyces pristinaespiralis 639.19 +- 1768.71 15 0 1 3 0.09 +- 0.17 15

No common domains found
Streptomyces afghaniensis 772 187.22 +- 266.49 16 0 2 3 0.08 +- 0.14 16

No common domains found
Streptomyces sp. RTd22 197.07 +- 251.03 42 0 11 3 0.08 +- 0.18 42

No common domains found
Streptomyces qinglanensis 301.15 +- 729.99 13 0 4 2 0.11 +- 0.22 13

No common domains found
Streptomyces sp. TP-A0874 976.78 +- 1581.75 11 0 5 3 0.09 +- 0.21 11

No common domains found
Streptomyces albus subsp. albus 128.36 +- 82.54 9 0 5 3 0.03 +- 0.06 9

No common domains found
Streptomyces yeochonensis CN732 226.88 +- 326.36 16 0 3 0 0.08 +- 0.17 16

No common domains found
Streptomyces sp. PalvLS-984 148.98 +- 139.54 9 0 3 1 0.10 +- 0.16 9

No common domains found
Streptomyces flavovirens 164.16 +- 188.77 16 0 6 2 0.11 +- 0.20 16

No common domains found
Streptomyces sp. AcE210 253.84 +- 429.41 39 0 4 1 0.08 +- 0.18 39

No common domains found
Embleya scabrispora DSM 41855 319.53 +- 709.48 38 0 10 5 0.09 +- 0.23 38

No common domains found
Streptomyces avellaneus 414.29 +- 884.46 13 0 5 1 0.07 +- 0.15 13

No common domains found
Streptomyces sp. NBS 14/10 306.34 +- 375.46 40 0 16 6 0.06 +- 0.15 40

No common domains found
Streptomyces alboflavus 149.81 +- 155.57 25 0 10 2 0.10 +- 0.20 25

No common domains found
Streptomyces silaceus 678.85 +- 1665.18 19 0 7 2 0.08 +- 0.16 19

No common domains found
Streptomyces sp. 3213.3 165.04 +- 220.93 29 0 3 3 0.08 +- 0.16 29

No common domains found
Streptomyces sp. SirexAA-E 230.33 +- 218.63 5 0 3 0 0.10 +- 0.10 5 1

PF07690 (3/5) Major Facilitator Superfamily
Streptomyces sp. XY511 266.42 +- 244.64 14 0 10 3 0.06 +- 0.17 14

No common domains found
Streptomyces swartbergensis 175.86 +- 221.23 10 0 6 1 0.11 +- 0.16 10

No common domains found
Streptomyces sp. NRRL F-3307 166.31 +- 173.03 25 0 5 0 0.10 +- 0.20 25

No common domains found
Streptomyces sp. DpondAA-D4 313.06 +- 506.88 12 0 1 3 0.07 +- 0.17 12

No common domains found
Streptomyces avermitilis MA-4680 = NBRC 14893 214.12 +- 267.95 37 0 12 2 0.07 +- 0.11 37

No common domains found
Streptomyces sp. NL15-2K 325.62 +- 680.11 37 0 13 1 0.08 +- 0.15 37

No common domains found
Streptomyces sp. NRRL S-575 237.57 +- 234.73 16 0 4 0 0.07 +- 0.17 16

No common domains found
Streptomyces niger 224.62 +- 316.31 35 0 9 6 0.09 +- 0.21 35

No common domains found
Streptomyces griseus 132.72 +- 121.71 18 0 7 5 0.11 +- 0.19 18

No common domains found
Streptomyces sp. F001 143.40 +- 217.71 35 0 6 2 0.11 +- 0.18 35

No common domains found
Streptomyces sp. ZL-24 95.05 +- 101.66 20 0 5 3 0.13 +- 0.20 20

No common domains found
Streptomyces sp. SDr-06 349.89 +- 503.89 22 0 11 3 0.04 +- 0.10 22

No common domains found
Streptomyces sp. NRRL F-2664 544.57 +- 934.16 13 0 9 2 0.07 +- 0.19 13

No common domains found
Streptomyces sp. MUSC 14 439.33 +- 624.69 34 0 13 5 0.06 +- 0.15 34

No common domains found
Streptomyces californicus 106.61 +- 85.04 14 0 3 5 0.09 +- 0.13 14

No common domains found
Streptomyces sp. HmicA12 313.33 +- 402.20 21 0 6 1 0.10 +- 0.22 21

No common domains found
Streptomyces atratus 847.68 +- 1461.33 16 0 0 0 0.04 +- 0.11 16

No common domains found
Streptomyces sp. NRRL S-237 172.12 +- 198.03 23 0 5 0 0.08 +- 0.19 23

No common domains found
Streptomyces sp. C 433.20 +- 441.11 16 0 7 3 0.07 +- 0.20 16

No common domains found
Streptomyces rimosus subsp. rimosus 110.86 +- 114.07 17 0 7 1 0.11 +- 0.18 17

No common domains found
Streptomyces sp. IMTB 1903 322.35 +- 489.88 19 0 5 1 0.08 +- 0.19 19

No common domains found
Streptomyces baarnensis 202.62 +- 243.54 16 0 9 5 0.10 +- 0.16 16

No common domains found
Streptomyces sp. ScaeMP-e83 93.60 +- 100.92 15 0 6 2 0.15 +- 0.21 15

No common domains found
Streptomyces xinghaiensis 153.40 +- 137.30 23 0 7 5 0.08 +- 0.15 23

No common domains found
Streptomyces cellulosae 258.39 +- 362.88 31 0 2 2 0.07 +- 0.12 31

No common domains found
Streptomyces sp. CNQ329 398.27 +- 449.30 21 0 5 0 0.08 +- 0.20 21

No common domains found
Streptomyces megasporus 407.46 +- 320.12 6 0 2 0 0.03 +- 0.06 6

No common domains found
Streptomyces virginiae 124.64 +- 114.73 18 0 7 0 0.11 +- 0.22 18

No common domains found
Streptomyces sp. CNH189 110.39 +- 90.01 4 0 0 0 0.18 +- 0.18 4

No common domains found
Streptomyces sp. 3214.6 314.64 +- 506.08 23 0 6 1 0.04 +- 0.11 23

No common domains found
Streptomyces albus 90.47 +- 24.62 3 0 1 1 0.04 +- 0.04 3

No common domains found
Streptomyces viridosporus 334.00 +- 265.50 9 0 3 0 0.03 +- 0.05 9

No common domains found
Streptomyces sp. LaPpAH-202 256.84 +- 333.64 11 0 5 4 0.09 +- 0.18 11

No common domains found
Streptomyces sp. PanSC19 298.54 +- 385.35 18 0 6 2 0.09 +- 0.20 18

No common domains found
Streptomyces sp. Wb2n-11 254.19 +- 380.05 23 0 6 1 0.08 +- 0.17 23

No common domains found
Streptomyces sp. NRRL S-1831 86.47 +- 83.93 9 0 2 0 0.16 +- 0.17 9

No common domains found
Streptomyces rimosus subsp. rimosus 566.74 +- 1896.60 28 0 10 7 0.06 +- 0.13 28

No common domains found
Streptomyces carpinensis 386.62 +- 583.44 22 0 1 3 0.04 +- 0.08 22

No common domains found
Streptomyces sp. AC1-42T 353.12 +- 338.33 13 0 5 3 0.08 +- 0.21 13

No common domains found
Streptomyces sp. 3212.3 181.21 +- 143.24 27 0 2 0 0.09 +- 0.15 27

No common domains found
Streptomyces sp. NRRL S-813 275.91 +- 516.24 26 0 3 1 0.09 +- 0.15 26

No common domains found
Streptomyces bicolor 132.78 +- 133.00 17 0 2 2 0.11 +- 0.17 17

No common domains found
Streptomyces rimosus subsp. rimosus 183.77 +- 381.96 15 0 6 3 0.11 +- 0.14 15

No common domains found
Streptomyces sp. OspMP-M45 142.69 +- 82.48 7 0 1 2 0.06 +- 0.16 7

No common domains found
Streptomyces rubellomurinus 76.80 +- 68.35 7 0 3 0 0.09 +- 0.17 7

No common domains found
Streptomyces niveiscabiei 71.64 +- 56.09 8 0 1 1 0.13 +- 0.15 8

No common domains found
Streptomyces griseus 155.04 +- 244.00 16 0 6 3 0.13 +- 0.15 16

No common domains found
Streptomyces niveus NCIMB 11891 408.41 +- 646.10 20 0 9 4 0.06 +- 0.14 20

No common domains found
Streptomyces sp. WAC00288 298.78 +- 287.54 12 0 4 1 0.07 +- 0.20 12

No common domains found
Streptomyces alboverticillatus 300.86 +- 168.68 4 0 1 0 0.05 +- 0.18 4

No common domains found
Streptomyces sp. MH60 62.97 +- 49.79 11 0 3 0 0.14 +- 0.17 11

No common domains found
Streptomyces griseus subsp. griseus NBRC 13350 136.19 +- 168.78 17 0 8 6 0.12 +- 0.18 17

No common domains found
Streptomyces atratus 175.59 +- 170.15 29 0 8 3 0.10 +- 0.21 29

No common domains found
Streptomyces sp. NRRL F-5065 245.91 +- 297.68 13 0 3 3 0.08 +- 0.12 13

No common domains found
Streptomyces albus 346.13 +- 351.22 10 0 1 1 0.05 +- 0.17 10

No common domains found
Streptomyces sp. NRRL F-5630 202.22 +- 376.64 12 0 2 1 0.11 +- 0.16 12

No common domains found
Streptomyces antioxidans 143.87 +- 138.17 21 0 4 2 0.10 +- 0.18 21

No common domains found
Streptomyces sp. 2133.1 125.26 +- 133.06 24 0 9 5 0.10 +- 0.19 24

No common domains found
Streptomyces roseus 266.54 +- 225.02 12 0 2 1 0.08 +- 0.17 12

No common domains found
Streptomyces sparsogenes DSM 40356 245.12 +- 342.39 21 0 9 3 0.08 +- 0.19 21

No common domains found
Streptomyces niveus 275.94 +- 335.35 8 0 2 1 0.07 +- 0.11 8

No common domains found
Streptomyces agglomeratus 253.84 +- 400.53 14 0 7 4 0.08 +- 0.16 14

No common domains found
Streptomyces sp. 93 292.72 +- 697.99 25 0 6 1 0.11 +- 0.17 25

No common domains found
Streptomyces sp. SA3_actG 84.17 +- 76.72 9 0 1 0 0.12 +- 0.19 9

No common domains found
Streptomyces sp. MJM8645 229.74 +- 293.53 29 0 16 5 0.09 +- 0.22 29

No common domains found
Streptomyces sp. MJM1172 402.23 +- 624.88 16 0 7 5 0.05 +- 0.12 16

No common domains found
Streptomyces pristinaespiralis ATCC 25486 622.36 +- 1702.83 11 0 0 1 0.12 +- 0.15 11

No common domains found
Streptomyces sp. EAG2 455.29 +- 408.73 8 0 2 0 0.04 +- 0.14 8

No common domains found
Streptomyces sviceus ATCC 29083 280.02 +- 509.98 29 0 6 2 0.07 +- 0.13 29

No common domains found
Streptomyces sp. CNQ-509 388.28 +- 511.48 30 0 10 1 0.07 +- 0.19 30

No common domains found
Streptomyces pratensis ATCC 33331 81.63 +- 109.26 17 0 4 2 0.14 +- 0.23 17

No common domains found
Streptomyces viridochromogenes 380.67 +- 460.90 34 0 4 2 0.05 +- 0.09 34

No common domains found
Streptomyces sp. NRRL S-1868 478.91 +- 781.78 10 0 2 1 0.05 +- 0.11 10

No common domains found
Streptomyces sp. 2R 106.45 +- 133.57 17 0 10 2 0.13 +- 0.20 17

No common domains found
Streptomyces sp. NRRL B-24085 269.61 +- 389.85 17 0 5 0 0.05 +- 0.09 17

No common domains found
Streptomyces sp. DpondAA-A50 151.43 +- 105.89 8 0 3 0 0.09 +- 0.17 8

No common domains found
Streptomyces sp. CNB091 155.92 +- 172.43 11 0 5 1 0.12 +- 0.14 11

No common domains found
Streptomyces durhamensis 206.01 +- 239.29 21 0 4 2 0.09 +- 0.17 21

No common domains found
Streptomyces sp. CNZ306 238.34 +- 402.72 21 0 6 1 0.10 +- 0.20 21

No common domains found
Streptomyces regalis 359.22 +- 678.43 19 0 5 2 0.07 +- 0.16 19

No common domains found
Streptomyces coelicolor A3(2) 362.08 +- 587.60 13 0 4 2 0.11 +- 0.18 13

No common domains found
Streptomyces sp. Alain-F2R5 364.74 +- 763.87 17 0 4 3 0.09 +- 0.16 17

No common domains found
Streptomyces sp. CcalMP-8W 94.03 +- 152.26 15 0 8 5 0.13 +- 0.18 15

No common domains found
Streptomyces agglomeratus 680.17 +- 944.11 12 0 4 3 0.06 +- 0.16 12

No common domains found
Streptomyces sp. NRRL S-337 291.50 +- 372.94 20 0 9 3 0.10 +- 0.20 20

No common domains found
Streptomyces sp. CNZ288 189.34 +- 215.41 20 0 8 2 0.12 +- 0.21 20

No common domains found
Streptomyces sp. CB01373 169.23 +- 229.63 16 0 5 0 0.10 +- 0.20 16

No common domains found
Streptomyces albidoflavus 103.06 +- 83.79 9 0 4 4 0.15 +- 0.20 9

No common domains found
Streptomyces silvensis 361.99 +- 649.72 30 0 9 6 0.10 +- 0.22 30

No common domains found
Streptomyces albidoflavus 108.45 +- 141.19 10 0 2 4 0.11 +- 0.15 10

No common domains found
Streptomyces sp. NRRL B-24572 182.88 +- 214.87 8 0 1 0 0.12 +- 0.24 8

No common domains found
Streptomyces actuosus 107.49 +- 129.19 9 0 1 0 0.11 +- 0.21 9

No common domains found
Streptomyces sp. DSM 15324 223.62 +- 302.72 22 0 3 1 0.10 +- 0.16 22

No common domains found
Streptomyces sp. XY593 242.08 +- 226.99 17 0 9 3 0.06 +- 0.17 17

No common domains found
Streptomyces auratus AGR0001 231.04 +- 279.57 21 0 15 5 0.07 +- 0.16 21

No common domains found
Streptomyces sp. WAC05458 121.20 +- 179.60 10 0 5 0 0.12 +- 0.20 10 1

PF00005 (5/10) ABC transporter
Streptomyces sp. WM6372 667.15 +- 1348.49 10 0 6 3 0.04 +- 0.10 10

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 127.13 +- 145.22 24 0 3 3 0.11 +- 0.20 24

No common domains found
Streptomyces sp. E5N298 130.00 +- 162.39 11 0 3 0 0.13 +- 0.19 11

No common domains found
Streptomyces lividans TK24 115.67 +- 100.01 6 0 3 2 0.16 +- 0.11 6

No common domains found
Streptomyces antimycoticus 266.48 +- 372.05 20 0 4 0 0.10 +- 0.21 20

No common domains found
Streptomyces sp. Ru72 215.52 +- 218.81 18 0 2 1 0.09 +- 0.15 18

No common domains found
Streptomyces sp. MBT76 760.75 +- 1666.53 20 0 11 3 0.06 +- 0.17 20

No common domains found
Streptomyces sp. 2221.1 354.62 +- 642.92 8 0 4 0 0.10 +- 0.20 8

No common domains found
Streptomyces sp. CNS615 423.51 +- 805.67 12 0 4 3 0.08 +- 0.16 12

No common domains found
Streptomyces globisporus subsp. globisporus 93.13 +- 109.80 11 0 3 2 0.13 +- 0.20 11

No common domains found
Streptomyces monomycini 236.98 +- 378.10 22 0 12 7 0.07 +- 0.18 22

No common domains found
Streptomyces misionensis 344.71 +- 595.76 25 0 10 3 0.08 +- 0.19 25

No common domains found
Streptomyces hoynatensis 391.47 +- 458.70 10 0 1 3 0.04 +- 0.15 10

No common domains found
Streptomyces sp. Ag109_O5-1 212.60 +- 238.81 28 0 5 1 0.08 +- 0.16 28

No common domains found
Streptomyces malaysiensis 179.29 +- 193.91 43 0 10 3 0.09 +- 0.16 43

No common domains found
Streptomyces bottropensis ATCC 25435 354.02 +- 762.85 15 0 5 3 0.09 +- 0.17 15

No common domains found
Streptomyces luteus 117.78 +- 136.91 15 0 5 1 0.13 +- 0.19 15

No common domains found
Streptomyces sp. NRRL S-15 415.18 +- 989.03 16 0 4 1 0.07 +- 0.12 16

No common domains found
Streptomyces albidoflavus 156.33 +- 178.32 13 0 6 5 0.09 +- 0.18 13

No common domains found
Streptomyces albus subsp. albus 216.38 +- 211.93 9 0 5 3 0.10 +- 0.19 9

No common domains found
Streptomyces kanasensis 228.00 +- 186.08 10 0 1 1 0.07 +- 0.19 10

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 236.06 +- 247.29 26 0 6 3 0.06 +- 0.14 26

No common domains found
Streptomyces sp. WAC04189 25.92 +- 7.70 4 0 2 0 0.16 +- 0.25 4

No common domains found
Streptomyces xinghaiensis 153.40 +- 137.30 23 0 7 5 0.08 +- 0.15 23

No common domains found
Streptomyces sp. CS057 217.17 +- 395.57 10 0 3 4 0.13 +- 0.16 10

No common domains found
Streptomyces angustmyceticus 435.28 +- 633.21 14 0 4 1 0.07 +- 0.18 14

No common domains found
Streptomyces sp. CNH287 179.85 +- 371.09 8 0 3 1 0.11 +- 0.21 8

No common domains found
Streptomyces sp. WAC05858 218.90 +- 313.70 22 0 5 1 0.09 +- 0.18 22

No common domains found
Streptomyces sp. wa1002 228.82 +- 312.32 9 0 4 1 0.10 +- 0.17 9

No common domains found
Streptomyces chattanoogensis 95.95 +- 111.73 20 0 7 2 0.13 +- 0.18 20

No common domains found
Streptomyces avidinii 124.42 +- 111.23 13 0 4 1 0.10 +- 0.14 13

No common domains found
Streptomyces sp. rh206 107.86 +- 79.26 8 0 2 1 0.13 +- 0.18 8

No common domains found
Streptomyces fungicidicus 229.38 +- 316.38 9 0 4 1 0.14 +- 0.24 9

No common domains found
Streptomyces sp. TverLS-915 140.70 +- 96.34 5 0 2 0 0.08 +- 0.19 5

No common domains found
Streptomyces sp. FXJ1.172 126.69 +- 144.00 21 0 2 2 0.09 +- 0.17 21

No common domains found
Streptomyces sp. ZS0098 146.95 +- 130.75 12 0 3 2 0.10 +- 0.14 12

No common domains found
Streptomyces sp. TP-A0875 263.49 +- 381.22 7 0 4 3 0.11 +- 0.21 7

No common domains found
Streptomyces sp. CS113 189.12 +- 309.59 15 0 8 2 0.13 +- 0.19 15

No common domains found
Streptomyces sp. 3212.4 339.14 +- 588.98 30 0 14 3 0.07 +- 0.15 30

No common domains found
Streptomyces sp. I6 193.07 +- 193.69 14 0 2 0 0.10 +- 0.20 14

No common domains found
Streptomyces platensis 245.39 +- 486.88 21 0 8 3 0.10 +- 0.21 21

No common domains found
Streptomyces sp. TLI_235 180.73 +- 294.15 17 0 3 1 0.12 +- 0.21 17

No common domains found
Streptomyces sp. 1 362.81 +- 601.09 18 0 5 2 0.07 +- 0.15 18

No common domains found
Streptomyces griseoplanus 247.90 +- 229.23 12 0 0 0 0.11 +- 0.24 12 1

PF00528 (6/12) Binding-protein-dependent transport system inner membrane component
Streptomyces sp. or3 125.65 +- 94.66 21 0 6 3 0.11 +- 0.17 21

No common domains found
Streptomyces sp. CC77 306.00 +- 426.06 4 0 0 1 0.08 +- 0.21 4 3

TIGR01509 (2/4) HAD hydrolase, family IA, variant 3
PF13419 (2/4) Haloacid dehalogenase-like hydrolase
PF00156 (2/4) Phosphoribosyl transferase domain
Streptomyces sp. t99 301.04 +- 693.67 12 0 5 3 0.10 +- 0.15 12

No common domains found
Streptomyces sp. NRRL F-5639 179.40 +- 134.28 13 0 5 4 0.06 +- 0.15 13

No common domains found
Streptomyces rimosus subsp. rimosus 95.86 +- 157.19 15 0 6 4 0.13 +- 0.14 15

No common domains found
Streptomyces venezuelae 603.17 +- 1429.78 15 0 5 2 0.07 +- 0.18 15

No common domains found
Streptomyces sp. CB02460 372.99 +- 643.39 11 0 1 1 0.09 +- 0.19 11

No common domains found
Streptomyces cinnamoneus 253.75 +- 320.92 12 0 8 3 0.07 +- 0.16 12

No common domains found
Streptomyces sp. 2233.2 304.27 +- 493.56 27 0 9 5 0.10 +- 0.19 27

No common domains found
Streptomyces sp. CS227 175.37 +- 254.35 14 0 8 4 0.12 +- 0.20 14

No common domains found
Streptomyces sp. NRRL F-7442 54.76 +- 41.04 11 0 1 0 0.15 +- 0.21 11

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 189.38 +- 155.88 24 0 6 1 0.08 +- 0.20 24

No common domains found
Streptomyces albidoflavus 161.63 +- 117.17 8 0 4 3 0.14 +- 0.17 8 1

PF00005 (4/8) ABC transporter
Streptomyces alfalfae 295.57 +- 552.28 19 0 7 4 0.08 +- 0.18 19

No common domains found
Streptomyces griseus subsp. griseus 429.10 +- 696.96 18 0 8 4 0.08 +- 0.18 18

No common domains found
Streptomyces sp. 1121.2 234.60 +- 288.33 19 0 6 1 0.09 +- 0.16 19

No common domains found
Streptomyces torulosus 196.75 +- 137.82 12 0 4 1 0.07 +- 0.10 12

No common domains found
Streptomyces sp. IGB124 367.48 +- 494.71 17 0 9 2 0.09 +- 0.21 17

No common domains found
Streptomyces albidoflavus 521.93 +- 483.40 7 0 2 1 0.02 +- 0.04 7

No common domains found
Streptomyces sp. CNT372 201.71 +- 179.86 6 0 2 1 0.12 +- 0.22 6 1

PF00005 (3/6) ABC transporter
Streptomyces sp. KS_5 270.82 +- 696.95 38 0 6 4 0.10 +- 0.17 38

No common domains found
Streptomyces sp. ADI95-17 199.92 +- 181.65 20 0 7 2 0.07 +- 0.15 20

No common domains found
Streptomyces sp. CB02400 116.78 +- 90.98 9 0 3 2 0.10 +- 0.21 9

No common domains found
Streptomyces lavenduligriseus 246.64 +- 290.49 19 0 7 4 0.11 +- 0.22 19

No common domains found
Streptomyces sp. Amel2xB2 199.43 +- 316.81 17 0 5 2 0.10 +- 0.17 17

No common domains found
Streptomyces rimosus subsp. rimosus 261.78 +- 488.27 18 0 7 3 0.08 +- 0.15 18

No common domains found
Streptomyces sp. M3 138.53 +- 134.36 21 0 6 0 0.09 +- 0.18 21

No common domains found
Streptomyces viridochromogenes 375.43 +- 714.54 30 0 4 2 0.07 +- 0.15 30

No common domains found
Streptomyces sp. SM1 367.31 +- 553.84 11 0 2 2 0.08 +- 0.15 11

No common domains found
Streptomyces luteoverticillatus 294.30 +- 307.89 21 0 9 6 0.07 +- 0.19 21

No common domains found
Streptomyces prunicolor NBRC 13075 316.57 +- 569.13 40 0 5 0 0.07 +- 0.15 40

No common domains found
Streptomyces sp. NBRC 110468 173.36 +- 210.62 14 0 2 2 0.08 +- 0.16 14

No common domains found
Streptomyces albidoflavus 74.09 +- 76.37 7 0 2 4 0.15 +- 0.16 7

No common domains found
Streptomyces sp. CG 926 83.22 +- 100.49 11 0 6 2 0.10 +- 0.17 11

No common domains found
Streptomyces sioyaensis 213.50 +- 225.32 20 0 5 3 0.06 +- 0.15 20

No common domains found
Streptomyces europaeiscabiei 80.26 +- 74.94 12 0 0 0 0.08 +- 0.16 12

No common domains found
Streptomyces sp. RV15 164.13 +- 203.37 34 0 7 2 0.09 +- 0.17 34

No common domains found
Streptomyces sp. Tu 4128 116.46 +- 130.01 12 0 4 0 0.13 +- 0.19 12

No common domains found
Streptomyces sp. SS 280.15 +- 402.44 13 0 5 1 0.08 +- 0.14 13

No common domains found
Streptomyces sp. WAC08452 47.98 +- 39.65 9 0 4 0 0.18 +- 0.23 9

No common domains found
Streptomyces sp. E2N166 98.55 +- 155.37 13 0 6 0 0.14 +- 0.17 13

No common domains found
Streptomyces sp. wa1071 339.82 +- 460.38 9 0 1 1 0.07 +- 0.12 9 1

PF07690 (5/9) Major Facilitator Superfamily
Streptomyces sp. CNT371 208.02 +- 212.59 15 0 5 2 0.10 +- 0.18 15

No common domains found
Streptomyces sp. WAC02707 35.08 +- 9.72 4 0 1 0 0.20 +- 0.21 4

No common domains found
Streptomyces sp. CB02613 332.68 +- 620.86 9 0 5 2 0.11 +- 0.22 9

No common domains found
Streptomyces fradiae 239.19 +- 244.19 16 0 5 5 0.11 +- 0.19 16

No common domains found
Streptomyces cinnamoneus 368.32 +- 475.06 18 0 10 7 0.08 +- 0.20 18

No common domains found
Streptomyces sp. MspMP-M5 161.87 +- 150.85 24 0 8 1 0.09 +- 0.22 24

No common domains found
Streptomyces sp. WAC 01325 186.80 +- 290.95 19 0 4 2 0.10 +- 0.18 19

No common domains found
Streptomyces sp. GP55 144.86 +- 174.14 22 0 8 2 0.08 +- 0.18 22

No common domains found
Streptomyces sp. WAC 05977 104.41 +- 117.50 26 0 7 0 0.12 +- 0.23 26

No common domains found
Streptomyces sp. PsTaAH-130 249.53 +- 329.78 20 0 7 1 0.08 +- 0.19 20

No common domains found
Streptomyces sp. RFCAC02 185.39 +- 197.97 13 0 9 4 0.08 +- 0.17 13

No common domains found
Streptomyces albus 424.32 +- 801.17 23 0 11 5 0.07 +- 0.16 23

No common domains found
Streptomyces sp. 303MFCol5.2 170.80 +- 386.99 16 0 1 1 0.13 +- 0.16 16

No common domains found
Streptomyces leeuwenhoekii 232.73 +- 451.41 12 0 5 1 0.11 +- 0.15 12

No common domains found
Streptomyces griseorubiginosus 252.36 +- 388.49 31 0 3 2 0.08 +- 0.13 31

No common domains found
Streptomyces sp. L2 378.22 +- 513.34 8 0 4 0 0.10 +- 0.21 8 1

PF07690 (4/8) Major Facilitator Superfamily
Streptomyces sp. TAA204 127.93 +- 110.87 14 0 6 5 0.13 +- 0.22 14

No common domains found
Streptomyces wuyuanensis 371.32 +- 395.70 7 0 4 1 0.09 +- 0.19 7

No common domains found
Streptomyces sp. SolWspMP-5a-2 783.20 +- 1402.51 17 0 7 2 0.07 +- 0.15 17 1

PF00005 (9/17) ABC transporter
Streptomyces sp. CS090A 304.55 +- 677.39 8 0 5 5 0.12 +- 0.13 8

No common domains found
Streptomyces sp. IMTB 2501 160.22 +- 232.81 26 0 5 2 0.10 +- 0.20 26

No common domains found
Streptomyces sp. OspMP-M43 273.11 +- 193.70 8 0 5 2 0.06 +- 0.12 8 1

PF00005 (5/8) ABC transporter
Streptomyces avermitilis 371.31 +- 735.04 25 0 8 1 0.06 +- 0.11 25

No common domains found
Streptomyces microflavus 86.20 +- 62.71 15 0 4 0 0.11 +- 0.20 15

No common domains found
Streptomyces lydicus 223.46 +- 241.32 22 0 7 3 0.10 +- 0.21 22

No common domains found
Streptomyces sp. DvalAA-19 124.44 +- 109.27 13 0 4 2 0.09 +- 0.16 13

No common domains found
Streptomyces sp. IgraMP-1 113.00 +- 107.94 6 0 2 1 0.11 +- 0.19 6

No common domains found
Streptomyces parvulus 421.53 +- 842.53 15 0 6 1 0.06 +- 0.13 15

No common domains found
Streptomyces prasinopilosus 159.70 +- 216.45 10 0 5 2 0.06 +- 0.08 10

No common domains found
Streptomyces sp. NRRL S-37 127.06 +- 197.10 9 0 2 1 0.13 +- 0.16 9

No common domains found
Streptomyces catenulae 243.69 +- 234.31 4 0 1 0 0.08 +- 0.16 4 1

PF12697 (2/4) Alpha/beta hydrolase family
Streptomyces sp. SolWspMP-sol2th 189.60 +- 344.79 16 0 8 3 0.11 +- 0.18 16

No common domains found
Streptomyces pluripotens 254.72 +- 333.36 15 0 3 1 0.11 +- 0.24 15

No common domains found
Streptomyces venezuelae 612.31 +- 1772.39 15 0 6 3 0.10 +- 0.20 15

No common domains found
Streptomyces acidiscabies 322.14 +- 476.10 22 0 5 2 0.07 +- 0.17 22

No common domains found
Streptomyces sp. NRRL B-12105 551.58 +- 1320.80 15 0 5 4 0.07 +- 0.16 15

No common domains found
Streptomyces sp. MMG1121 427.98 +- 474.84 24 0 11 4 0.07 +- 0.18 24

No common domains found
Streptomyces californicus 185.13 +- 183.27 17 0 5 4 0.08 +- 0.17 17

No common domains found
Streptomyces sp. ADI98-12 140.04 +- 145.03 11 0 6 1 0.07 +- 0.15 11

No common domains found
Streptomyces variegatus 186.69 +- 290.53 19 0 4 1 0.11 +- 0.18 19

No common domains found
Streptomyces humi 295.17 +- 348.71 18 0 7 2 0.07 +- 0.11 18

No common domains found
Streptomyces albidoflavus 193.33 +- 228.85 10 0 5 5 0.13 +- 0.16 10 1

PF00005 (5/10) ABC transporter
Streptomyces sp. CB02959 155.73 +- 169.32 18 0 5 3 0.08 +- 0.14 18

No common domains found
Streptomyces sp. IB2014 011-12 128.31 +- 169.49 18 0 5 3 0.12 +- 0.17 18

No common domains found
Streptomyces alboviridis 239.16 +- 390.04 23 0 10 3 0.08 +- 0.16 23

No common domains found
Streptomyces scabiei 145.56 +- 130.92 13 0 1 0 0.08 +- 0.16 13

No common domains found
Streptomyces sp. CB01249 247.75 +- 203.11 15 0 3 1 0.08 +- 0.21 15

No common domains found
Streptomyces sp. SCA2-2 310.99 +- 389.54 6 0 3 0 0.11 +- 0.24 6 3

PF13193 (3/6) AMP-binding enzyme C-terminal domain
PF00501 (3/6) AMP-binding enzyme
PF00005 (3/6) ABC transporter
Streptomyces griseofuscus 288.80 +- 364.11 21 0 5 2 0.06 +- 0.13 21

No common domains found
Streptomyces sp. FM008 164.55 +- 53.12 2 0 0 0 0.04 +- 0.01 2 12

TIGR01733 (1/2) amino acid adenylation domain
PF13649 (1/2) Methyltransferase domain
PF13280 (1/2) WYL domain
PF11695 (1/2) Domain of unknown function (DUF3291)
PF09334 (1/2) tRNA synthetases class I (M)
PF07883 (1/2) Cupin domain
PF07859 (1/2) alpha/beta hydrolase fold
PF01494 (1/2) FAD binding domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00581 (1/2) Rhodanese-like domain
PF00501 (1/2) AMP-binding enzyme
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
Streptomyces fradiae 271.82 +- 374.95 12 0 4 5 0.11 +- 0.14 12 1

PF00005 (6/12) ABC transporter
Streptomyces qaidamensis 328.36 +- 473.49 17 0 5 2 0.09 +- 0.18 17

No common domains found
Streptomyces sp. SceaMP-e96 330.31 +- 570.98 31 0 16 7 0.08 +- 0.18 31

No common domains found
Streptomyces virginiae 293.39 +- 401.85 14 0 9 5 0.07 +- 0.16 14

No common domains found
Streptomyces sp. NRRL S-1022 347.26 +- 520.80 17 0 8 1 0.05 +- 0.13 17

No common domains found
Streptomyces sp. JV178 242.73 +- 323.84 25 0 7 1 0.09 +- 0.19 25

No common domains found
Streptomyces sp. ScaeMP-e48 138.39 +- 152.79 23 0 12 3 0.09 +- 0.17 23

No common domains found
Streptomyces cattleya NRRL 8057 = DSM 46488 220.76 +- 252.18 11 0 7 2 0.14 +- 0.25 11

No common domains found
Streptomyces sp. 1331.2 310.03 +- 509.11 31 0 15 6 0.10 +- 0.22 31

No common domains found
Streptomyces albidoflavus 229.10 +- 172.49 9 0 3 2 0.05 +- 0.07 9

No common domains found
Streptomyces xinghaiensis S187 160.53 +- 161.63 12 0 6 3 0.09 +- 0.19 12

No common domains found
Streptomyces sp. 61 402.43 +- 643.85 17 0 3 1 0.10 +- 0.21 17

No common domains found
Streptomyces griseus subsp. griseus 337.10 +- 379.10 7 0 3 2 0.08 +- 0.22 7

No common domains found
Streptomyces sp. WAC07149 335.47 +- 404.38 11 0 6 2 0.06 +- 0.16 11

No common domains found
Streptomyces sp. CB02414 196.82 +- 224.77 17 0 6 1 0.07 +- 0.13 17

No common domains found
Streptomyces sp. CdTB01 483.08 +- 937.34 30 0 8 2 0.07 +- 0.17 30

No common domains found
Streptomyces sp. E1N211 152.36 +- 115.03 16 0 5 2 0.09 +- 0.11 16

No common domains found
Streptomyces sp. FxanaC1 281.50 +- 315.29 12 0 7 3 0.10 +- 0.18 12

No common domains found
Streptomyces mirabilis 316.23 +- 624.71 37 0 3 3 0.10 +- 0.18 37

No common domains found
Streptomyces albidoflavus 221.81 +- 326.97 9 0 4 4 0.10 +- 0.18 9

No common domains found
Streptomyces decoyicus 237.28 +- 321.89 17 0 4 4 0.10 +- 0.20 17

No common domains found
Streptomyces albulus PD-1 370.44 +- 473.75 23 0 11 2 0.05 +- 0.11 23

No common domains found
Streptomyces acidiscabies 322.31 +- 405.23 23 0 1 1 0.06 +- 0.13 23

No common domains found
Streptomyces sp. M56 389.91 +- 584.66 41 0 8 4 0.07 +- 0.17 41

No common domains found
Streptomyces sp. rh207 106.57 +- 93.94 6 0 0 1 0.12 +- 0.22 6

No common domains found
Streptomyces thermoautotrophicus 112.91 +- 101.34 5 0 0 0 0.12 +- 0.25 5

No common domains found
Streptomyces sp. LHW50302 525.05 +- 1687.79 23 0 8 4 0.09 +- 0.20 23

No common domains found
Streptomyces scabiei 800.31 +- 1372.50 10 0 0 0 0.04 +- 0.09 10

No common domains found
Streptomyces lydicus 303.78 +- 342.11 29 0 12 4 0.06 +- 0.15 29

No common domains found
Streptomyces nodosus 1109.46 +- 2421.58 10 0 4 3 0.09 +- 0.24 10

No common domains found
Streptomyces sp. GSSD-12 389.58 +- 446.23 22 0 6 5 0.06 +- 0.15 22

No common domains found
Streptomyces wadayamensis 102.77 +- 73.02 7 0 4 4 0.14 +- 0.21 7

No common domains found
Streptomyces sp. 142MFCol3.1 160.54 +- 235.14 27 0 3 2 0.12 +- 0.20 27

No common domains found
Streptomyces xiaopingdaonensis 199.10 +- 196.78 13 0 5 1 0.08 +- 0.18 13

No common domains found
Streptomyces eurocidicus 195.68 +- 251.08 12 0 11 2 0.08 +- 0.21 12

No common domains found
Streptomyces sp. TLI_185 233.23 +- 331.65 28 0 7 3 0.10 +- 0.16 28

No common domains found
Streptomyces sp. SM8 60.78 +- 40.56 8 0 4 3 0.15 +- 0.14 8

No common domains found
Streptomyces griseus subsp. griseus 298.98 +- 379.03 9 0 4 2 0.07 +- 0.15 9

No common domains found
Streptomyces rimosus subsp. paromomycinus 353.12 +- 574.53 30 0 17 5 0.05 +- 0.11 30

No common domains found
Streptomyces sp. AA0539 223.84 +- 227.32 8 0 1 2 0.11 +- 0.24 8

No common domains found
Streptomyces sp. SM5 158.26 +- 194.27 10 0 3 2 0.08 +- 0.09 10

No common domains found
Streptomyces albidoflavus 247.84 +- 322.72 12 0 6 5 0.08 +- 0.16 12

No common domains found
Streptomyces sp. NRRL F-5122 139.26 +- 103.26 24 0 1 0 0.11 +- 0.17 24

No common domains found
Streptomyces graminilatus 85.70 +- 123.36 16 0 3 2 0.11 +- 0.16 16

No common domains found
Streptomyces alfalfae 393.46 +- 824.45 14 0 8 3 0.08 +- 0.18 14

No common domains found
Streptomyces sp. 67 228.39 +- 346.70 29 0 12 3 0.12 +- 0.21 29

No common domains found
Streptomyces sp. 42 142.79 +- 175.33 29 0 5 3 0.11 +- 0.18 29

No common domains found
Streptomyces sp. OK885 364.80 +- 790.13 30 0 12 4 0.09 +- 0.18 30

No common domains found
Streptomyces yerevanensis 143.54 +- 159.19 46 0 6 2 0.09 +- 0.15 46

No common domains found
Streptomyces sp. NRRL S-325 121.65 +- 243.04 23 0 4 3 0.13 +- 0.20 23

No common domains found
Streptomyces sp. NRRL WC-3626 267.69 +- 321.96 10 0 1 1 0.13 +- 0.22 10 1

PF00005 (5/10) ABC transporter
Streptomyces sp. CMB-StM0423 156.45 +- 183.57 16 0 2 0 0.10 +- 0.17 16

No common domains found
Streptomyces rimosus subsp. rimosus 109.04 +- 100.56 19 0 6 1 0.11 +- 0.20 19

No common domains found
Streptomyces leeuwenhoekii 20.95 +- 11.00 4 0 0 1 0.16 +- 0.12 4

No common domains found
Streptomyces sp. NRRL F-2202 73.74 +- 46.42 12 0 4 4 0.12 +- 0.18 12

No common domains found
Streptomyces sp. TLI_105 173.10 +- 175.82 19 0 5 1 0.10 +- 0.21 19

No common domains found
Streptomyces sp. MOE7 304.23 +- 463.39 21 0 8 2 0.10 +- 0.20 21

No common domains found
Streptomyces sp. NRRL B-1347 437.45 +- 629.17 23 0 9 7 0.06 +- 0.16 23

No common domains found
Streptomyces sp. N1 64.20 +- 74.80 8 0 2 4 0.16 +- 0.19 8

No common domains found
Streptomyces sp. NRRL S-118 256.19 +- 372.70 9 0 4 4 0.10 +- 0.17 9

No common domains found
Streptomyces sp. CB02923 519.96 +- 678.35 25 0 12 4 0.04 +- 0.13 25

No common domains found
Streptomyces sp. WAC04657 274.05 +- 234.84 12 0 4 1 0.07 +- 0.19 12

No common domains found
Streptomyces albidoflavus 96.28 +- 77.59 9 0 4 5 0.14 +- 0.15 9

No common domains found
Streptomyces rimosus subsp. rimosus 95.10 +- 114.15 19 0 9 2 0.11 +- 0.18 19

No common domains found
Streptomyces sp. Termitarium-T10T-6 482.27 +- 591.30 5 0 3 2 0.11 +- 0.22 5 1

PF00005 (3/5) ABC transporter
Streptomyces sp. BK239 237.69 +- 351.76 13 0 4 2 0.11 +- 0.18 13

No common domains found
Streptomyces viridochromogenes 544.47 +- 537.86 16 0 4 1 0.06 +- 0.14 16

No common domains found
Streptomyces sp. F-3 195.12 +- 175.61 9 0 3 1 0.09 +- 0.20 9

No common domains found
Streptomyces coelicoflavus 341.15 +- 356.98 13 0 1 1 0.07 +- 0.14 13

No common domains found
Streptomyces sp. E5N91 75.26 +- 92.29 6 0 1 1 0.17 +- 0.20 6

No common domains found
Streptomyces sp. NRRL S-31 217.90 +- 242.11 24 0 13 5 0.06 +- 0.13 24

No common domains found
Streptomyces avermitilis 323.21 +- 552.32 33 0 8 1 0.06 +- 0.13 33

No common domains found
Streptomyces vitaminophilus DSM 41686 193.93 +- 213.63 19 0 5 2 0.07 +- 0.17 19

No common domains found
Streptomyces sp. NTH33 500.26 +- 692.74 10 0 2 1 0.06 +- 0.18 10

No common domains found
Streptomyces sp. SA3_actF 28.86 +- 11.27 2 0 0 0 0.14 +- 0.16 2 9

TIGR00996 (1/2) virulence factor Mce family protein
PF13508 (1/2) Acetyltransferase (GNAT) domain
PF13406 (1/2) Transglycosylase SLT domain
PF11887 (1/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (1/2) MlaD protein
PF02405 (1/2) Permease MlaE
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00089 (1/2) Trypsin
PF00005 (1/2) ABC transporter
Streptomyces sp. URHA0041 520.78 +- 1090.96 17 0 6 1 0.08 +- 0.16 17

No common domains found
Streptomyces sulphureus DSM 40104 189.61 +- 252.87 25 0 7 4 0.10 +- 0.21 25

No common domains found
Streptomyces nigra 320.13 +- 425.41 16 0 1 1 0.07 +- 0.14 16

No common domains found
Streptomyces sp. NRRL WC-3702 91.31 +- 153.23 16 0 6 4 0.13 +- 0.14 16

No common domains found
Streptomyces sp. WAC06128 42.09 +- 25.40 9 0 3 0 0.18 +- 0.24 9

No common domains found
Streptomyces sp. NRRL B-1140 269.06 +- 383.64 9 0 2 1 0.10 +- 0.18 9

No common domains found
Streptomyces sp. SMS_SU21 208.88 +- 202.62 8 0 1 2 0.09 +- 0.10 8

No common domains found
Streptomyces lividans TK24 112.44 +- 112.43 8 0 5 1 0.12 +- 0.17 8

No common domains found
Streptomyces sp. CNZ301 183.03 +- 324.82 19 0 7 0 0.12 +- 0.23 19

No common domains found
Streptomyces rubrogriseus 124.09 +- 142.47 12 0 3 1 0.12 +- 0.17 12

No common domains found
Streptomyces indicus 186.87 +- 214.99 13 0 4 0 0.10 +- 0.20 13

No common domains found
Streptomyces albidoflavus 82.91 +- 74.96 12 0 2 4 0.13 +- 0.19 12

No common domains found
Streptomyces sp. NRRL F-4474 430.22 +- 1435.43 18 0 7 0 0.11 +- 0.19 18

No common domains found
Streptomyces griseocarneus 807.06 +- 1070.48 24 0 10 3 0.04 +- 0.15 24

No common domains found
Streptomyces huasconensis 339.71 +- 551.42 6 0 3 2 0.09 +- 0.17 6

No common domains found
Streptomyces sp. CB01201 237.64 +- 319.75 20 0 8 3 0.10 +- 0.16 20

No common domains found
Streptomyces albus 345.24 +- 665.09 21 0 10 5 0.08 +- 0.18 21

No common domains found
Streptomyces sp. NRRL F-6676 633.92 +- 1345.60 15 0 5 4 0.05 +- 0.12 15

No common domains found
Streptomyces resistomycificus 245.55 +- 316.48 17 0 4 1 0.09 +- 0.15 17

No common domains found
Streptomyces sp. WM6368 191.24 +- 148.88 9 0 5 0 0.09 +- 0.16 9 1

PF07690 (5/9) Major Facilitator Superfamily
Streptomyces sp. Ag109_G2-6 328.12 +- 514.20 10 0 6 1 0.07 +- 0.17 10

No common domains found
Streptomyces sp. LaPpAH-95 251.84 +- 254.56 19 0 5 2 0.08 +- 0.19 19

No common domains found
Streptomyces formicae 386.94 +- 603.07 30 0 14 11 0.09 +- 0.21 30

No common domains found
Streptomyces abyssalis 197.04 +- 205.94 11 0 3 0 0.10 +- 0.19 11

No common domains found
Streptomyces katrae 537.60 +- 1069.67 15 0 8 1 0.07 +- 0.18 15

No common domains found
Streptomyces sp. MG 231.68 +- 251.29 31 0 6 2 0.10 +- 0.18 31

No common domains found
Streptomyces sp. wa1063 758.01 +- 598.12 7 0 2 1 0.04 +- 0.06 7

No common domains found
Streptomyces sp. Ag82_G6-1 229.29 +- 397.73 20 0 5 3 0.10 +- 0.16 20

No common domains found
Streptomyces sp. WAC06273 123.53 +- 248.64 14 0 6 0 0.13 +- 0.21 14

No common domains found
Streptomyces sp. H-KF8 178.49 +- 108.31 10 0 4 1 0.08 +- 0.18 10

No common domains found
Streptomyces albus subsp. albus 183.37 +- 211.73 7 0 3 4 0.12 +- 0.16 7

No common domains found
Streptomyces sp. rh34 482.49 +- 1099.58 17 0 5 0 0.11 +- 0.17 17

No common domains found
Streptomyces sp. NRRL WC-3703 98.82 +- 152.53 16 0 6 4 0.12 +- 0.13 16

No common domains found
Streptomyces rimosus subsp. rimosus 85.54 +- 84.46 16 0 8 3 0.12 +- 0.19 16

No common domains found
Streptomyces xinghaiensis 244.34 +- 312.55 18 0 7 5 0.09 +- 0.15 18

No common domains found
Streptomyces sp. Root63 272.55 +- 507.04 19 0 8 3 0.12 +- 0.19 19

No common domains found
Streptomyces scabiei 200.94 +- 359.44 11 0 2 0 0.11 +- 0.15 11

No common domains found
Streptomyces rimosus 174.17 +- 197.00 22 0 9 5 0.09 +- 0.19 22

No common domains found
Streptomyces spongiicola 326.06 +- 386.45 9 0 6 2 0.08 +- 0.20 9

No common domains found
Streptomyces chartreusis NRRL 3882 127.18 +- 164.70 19 0 4 2 0.12 +- 0.16 19

No common domains found
Streptomyces zinciresistens K42 279.34 +- 275.88 12 0 1 3 0.06 +- 0.16 12

No common domains found
Streptomyces rimosus subsp. rimosus 95.86 +- 157.19 15 0 6 4 0.13 +- 0.14 15

No common domains found
Streptomyces sp. CB03238 221.83 +- 285.95 18 0 9 3 0.11 +- 0.19 18

No common domains found
Streptomyces albidoflavus 222.10 +- 291.52 18 0 7 5 0.09 +- 0.18 18

No common domains found
Streptomyces sp. LaPpAH-201 215.33 +- 356.71 12 0 4 4 0.12 +- 0.19 12

No common domains found
Streptomyces sp. 94 222.77 +- 320.85 37 0 11 2 0.09 +- 0.17 37

No common domains found
Streptomyces sp. WM6391 106.48 +- 85.60 8 0 3 2 0.13 +- 0.11 8

No common domains found
Streptomyces somaliensis DSM 40738 189.33 +- 108.92 3 0 2 0 0.03 +- 0.04 3

No common domains found
Streptomyces rochei 76.48 +- 97.54 7 0 2 0 0.15 +- 0.21 7

No common domains found
Streptomyces tirandamycinicus 461.11 +- 733.57 11 0 5 2 0.06 +- 0.13 11

No common domains found
Streptomyces griseus 200.16 +- 230.91 25 0 9 5 0.08 +- 0.17 25

No common domains found
Streptomyces sp. WAC08241 120.97 +- 95.08 6 0 2 0 0.08 +- 0.18 6 1

PF07690 (3/6) Major Facilitator Superfamily
Streptomyces lydicus 233.03 +- 315.71 27 0 11 5 0.09 +- 0.20 27

No common domains found
Streptomyces yangpuensis 847.86 +- 2225.09 11 0 5 1 0.06 +- 0.14 11

No common domains found
Streptomyces sp. NRRL F-2295 243.79 +- 294.77 7 0 2 4 0.09 +- 0.16 7

No common domains found
Streptomyces sp. NRRL F-5126 407.76 +- 444.52 18 0 3 1 0.08 +- 0.16 18

No common domains found
Streptomyces aurantiacus 351.50 +- 382.45 15 0 1 0 0.06 +- 0.09 15

No common domains found
Streptomyces sp. NRRL B-24085 294.39 +- 399.09 16 0 5 0 0.07 +- 0.17 16

No common domains found
Streptomyces griseorubiginosus 244.82 +- 186.77 18 0 3 2 0.06 +- 0.12 18

No common domains found
Streptomyces aureocirculatus 318.59 +- 549.22 24 0 9 5 0.07 +- 0.17 24

No common domains found
Streptomyces albidoflavus 112.01 +- 73.51 8 0 3 4 0.15 +- 0.19 8

No common domains found
Streptomyces sp. NRRL S-4 290.84 +- 530.75 13 0 4 0 0.09 +- 0.16 13

No common domains found
Streptomyces clavuligerus 248.50 +- 277.91 19 0 11 1 0.05 +- 0.12 19

No common domains found
Streptomyces sp. SAT1 230.87 +- 225.07 9 0 1 0 0.09 +- 0.23 9

No common domains found
Streptomyces sp. GZWMJZ-114 150.63 +- 142.99 11 0 2 0 0.06 +- 0.11 11

No common domains found
Streptomyces griseoluteus 311.23 +- 819.72 19 0 4 3 0.12 +- 0.22 19

No common domains found
Streptomyces himastatinicus ATCC 53653 235.13 +- 308.79 34 0 15 4 0.09 +- 0.19 34

No common domains found
Streptomyces sp. NRRL WC-3744 122.73 +- 129.92 19 0 6 2 0.12 +- 0.20 19

No common domains found
Streptomyces sp. NRRL F-5635 76.37 +- 50.17 9 0 1 0 0.11 +- 0.13 9

No common domains found
Streptomyces sp. TLI_171 303.22 +- 506.07 20 0 4 2 0.07 +- 0.13 20

No common domains found
Streptomyces sp. CS207 112.52 +- 186.38 12 0 5 0 0.16 +- 0.27 12

No common domains found
Streptomyces gilvigriseus 316.28 +- 458.12 10 0 0 1 0.08 +- 0.20 10

No common domains found
Streptomyces turgidiscabies Car8 289.29 +- 334.35 28 0 5 1 0.05 +- 0.09 28

No common domains found
Streptomyces albidoflavus 216.18 +- 251.34 6 0 3 3 0.08 +- 0.06 6 2

PF02624 (3/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00005 (3/6) ABC transporter
Streptomyces sp. SM13 170.36 +- 176.46 14 0 6 5 0.10 +- 0.17 14

No common domains found
Streptomyces pluripotens 217.45 +- 175.24 9 0 3 1 0.09 +- 0.22 9

No common domains found
Streptomyces sp. Root1304 253.68 +- 314.03 11 0 1 2 0.10 +- 0.24 11

No common domains found
Streptomyces sp. 2132.2 187.33 +- 326.41 16 0 2 1 0.08 +- 0.18 16

No common domains found
Streptomyces ochraceiscleroticus 217.47 +- 280.50 20 0 3 1 0.07 +- 0.16 20

No common domains found
Streptomyces sp. BvitLS-983 161.51 +- 242.43 8 0 3 2 0.12 +- 0.22 8 1

PF00005 (5/8) ABC transporter
Streptomyces rimosus subsp. rimosus 102.67 +- 118.39 17 0 8 2 0.11 +- 0.17 17

No common domains found
Streptomyces sp. NRRL S-350 223.67 +- 297.62 28 0 10 3 0.07 +- 0.16 28

No common domains found
Streptomyces sp. 75 230.84 +- 364.01 31 0 7 2 0.09 +- 0.14 31

No common domains found
Streptomyces sp. ScaeMP-e122 151.07 +- 128.25 11 0 4 1 0.11 +- 0.24 11

No common domains found
Streptomyces sp. TM32 308.26 +- 341.37 10 0 2 4 0.09 +- 0.16 10

No common domains found
Streptomyces triticisoli 583.38 +- 719.47 4 0 1 1 0.06 +- 0.11 4 2

PF07690 (2/4) Major Facilitator Superfamily
PF00743 (2/4) Flavin-binding monooxygenase-like
Streptomyces sp. NRRL B-3253 147.71 +- 185.73 13 0 5 3 0.11 +- 0.17 13

No common domains found
Streptomyces sp. NRRL S-455 106.93 +- 123.50 14 0 1 0 0.15 +- 0.21 14

No common domains found
Streptomyces nanshensis 231.56 +- 323.81 10 0 3 3 0.07 +- 0.14 10

No common domains found
Streptomyces californicus 113.88 +- 90.76 10 0 3 5 0.10 +- 0.14 10

No common domains found
Streptomyces tsukubensis NRRL18488 143.48 +- 182.66 6 0 2 1 0.10 +- 0.15 6

No common domains found
Streptomyces sp. OspMP-M45 199.71 +- 239.39 6 0 1 2 0.07 +- 0.16 6

No common domains found
Streptomyces varsoviensis 417.34 +- 440.42 23 0 15 9 0.05 +- 0.16 23

No common domains found
Streptomyces acidiscabies 343.30 +- 382.84 28 0 4 2 0.07 +- 0.19 28

No common domains found
Streptomyces sp. Amel2xE9 232.50 +- 196.41 10 0 6 2 0.07 +- 0.15 10

No common domains found
Streptomyces sp. TOR3209 49.76 +- 38.51 6 0 1 0 0.18 +- 0.23 6

No common domains found
Streptomyces mirabilis 256.56 +- 423.87 33 0 10 0 0.09 +- 0.18 33

No common domains found
Streptomyces sp. TP-A0356 163.86 +- 161.49 14 0 6 0 0.08 +- 0.20 14

No common domains found
Streptomyces sp. FR-008 253.86 +- 501.08 16 0 4 3 0.10 +- 0.21 16

No common domains found
Streptomyces sp. NRRL F-5135 175.89 +- 212.73 13 0 2 1 0.07 +- 0.12 13

No common domains found
Streptomyces vietnamensis 245.36 +- 344.90 13 0 1 0 0.12 +- 0.20 13

No common domains found
Streptomyces sp. NRRL F-6677 606.89 +- 1351.00 15 0 5 4 0.06 +- 0.14 15

No common domains found
Streptomyces sp. NRRL S-1896 269.35 +- 266.86 20 0 4 2 0.06 +- 0.11 20

No common domains found
Streptomyces acidiscabies 137.08 +- 123.24 16 0 7 2 0.11 +- 0.19 16

No common domains found
Streptomyces bikiniensis 201.60 +- 190.34 12 0 2 1 0.07 +- 0.21 12

No common domains found
Streptomyces sp. LUP47B 136.99 +- 214.47 42 0 3 0 0.10 +- 0.17 42

No common domains found
Streptomyces sp. WAC08401 49.26 +- 42.10 8 0 3 0 0.16 +- 0.20 8

No common domains found
Streptomyces sp. NBRC 110611 353.05 +- 437.22 23 0 8 5 0.05 +- 0.13 23

No common domains found
Streptomyces sp. WMMB 322 319.51 +- 432.39 10 0 3 1 0.13 +- 0.26 10

No common domains found
Streptomyces sp. CNZ279 245.72 +- 324.79 29 0 13 5 0.09 +- 0.16 29

No common domains found
Streptomyces sp. NRRL S-87 303.34 +- 601.96 12 0 7 2 0.07 +- 0.14 12

No common domains found
Streptomyces prasinus 128.46 +- 105.82 3 0 1 1 0.14 +- 0.15 3 1

PF00664 (2/3) ABC transporter transmembrane region
Streptomyces azureus 351.84 +- 514.47 13 0 1 1 0.08 +- 0.16 13

No common domains found
Streptomyces sp. GKU 895 65.29 +- 64.57 15 0 3 0 0.15 +- 0.15 15

No common domains found
Streptomyces sp. 2112.5 147.89 +- 140.32 26 0 10 6 0.09 +- 0.18 26

No common domains found
Streptomyces californicus 129.15 +- 133.74 18 0 6 5 0.11 +- 0.22 18

No common domains found
Streptomyces rhizosphaericus 361.84 +- 457.18 19 0 5 4 0.07 +- 0.14 19

No common domains found
Streptomyces sp. rh195 96.17 +- 74.04 8 0 2 1 0.13 +- 0.18 8

No common domains found
Streptomyces sp. SolWspMP-sol7th 22.61 +- 0.00 1 0 0 0 0.09 +- 0.03 1 2

PF02734 (1/1) DAK2 domain
PF02733 (1/1) Dak1 domain
Streptomyces olivaceus 78.99 +- 93.93 18 0 6 1 0.13 +- 0.21 18

No common domains found
Streptomyces sp. Root66D1 321.55 +- 311.63 9 0 1 2 0.08 +- 0.19 9

No common domains found
Streptomyces albidoflavus 91.80 +- 58.39 11 0 4 3 0.16 +- 0.21 11 1

PF00005 (6/11) ABC transporter
Streptomyces sp. 2321.6 109.10 +- 117.74 18 0 9 6 0.11 +- 0.19 18

No common domains found
Streptomyces sp. H036 111.06 +- 108.39 19 0 9 3 0.08 +- 0.16 19

No common domains found
Streptomyces longwoodensis 425.69 +- 454.72 9 0 5 1 0.09 +- 0.21 9

No common domains found
Streptomyces sp. NRRL S-646 409.78 +- 813.36 35 0 7 2 0.10 +- 0.19 35

No common domains found
Streptomyces viridochromogenes 118.03 +- 148.12 5 0 0 0 0.08 +- 0.20 5

No common domains found
Streptomyces sp. NRRL WC-3774 204.94 +- 287.33 19 0 4 2 0.09 +- 0.14 19

No common domains found
Streptomyces brasiliensis 114.03 +- 86.01 14 0 3 5 0.09 +- 0.13 14

No common domains found
Streptomyces sp. EN16 154.83 +- 102.91 17 0 4 2 0.09 +- 0.15 17

No common domains found
Streptomyces lydicus 292.03 +- 442.38 20 0 8 4 0.07 +- 0.15 20

No common domains found
Streptomyces populi 255.29 +- 365.12 13 0 5 0 0.11 +- 0.19 13

No common domains found
Streptomyces mobaraensis NBRC 13819 = DSM 40847 375.53 +- 683.85 19 0 9 7 0.05 +- 0.16 19

No common domains found
Streptomyces sp. OV198 177.67 +- 179.24 33 0 6 4 0.07 +- 0.13 33

No common domains found
Streptomyces viridochromogenes Tue57 205.86 +- 198.71 25 0 5 3 0.07 +- 0.12 25

No common domains found
Streptomyces sp. TSRI0445 200.77 +- 231.91 19 0 9 3 0.11 +- 0.17 19

No common domains found
Streptomyces milbemycinicus 363.92 +- 396.53 37 0 9 3 0.06 +- 0.13 37

No common domains found
Streptomyces sp. MnatMP-M77 156.98 +- 186.41 14 0 8 5 0.12 +- 0.20 14

No common domains found
Streptomyces griseoflavus 234.54 +- 275.14 19 0 8 3 0.07 +- 0.17 19

No common domains found
Streptomyces curacoi 355.20 +- 701.85 25 0 7 3 0.07 +- 0.15 25

No common domains found
Streptomyces sp. ScaeMP-e10 256.92 +- 491.56 12 0 6 5 0.12 +- 0.20 12

No common domains found
Streptomyces albidoflavus 143.12 +- 159.63 12 0 4 4 0.11 +- 0.20 12

No common domains found
Streptomyces sp. WMMB 322 262.29 +- 328.05 11 0 4 1 0.10 +- 0.22 11

No common domains found
Streptomyces sp. MMG1064 391.25 +- 537.35 7 0 4 0 0.06 +- 0.12 7 1

PF07690 (4/7) Major Facilitator Superfamily
Streptomyces sp. 136MFCol5.1 147.11 +- 131.79 14 0 1 0 0.11 +- 0.21 14

No common domains found
Streptomyces sp. DvalAA-43 329.18 +- 393.98 17 0 6 3 0.05 +- 0.14 17

No common domains found
Streptomyces viridochromogenes DSM 40736 164.14 +- 174.20 23 0 6 3 0.10 +- 0.19 23

No common domains found
Streptomyces sp. WAC 06738 202.69 +- 202.53 15 0 1 1 0.09 +- 0.18 15

No common domains found
Streptomyces lydicus 164.89 +- 253.41 17 0 5 3 0.12 +- 0.22 17

No common domains found
Streptomyces sp. 2112.3 330.24 +- 463.61 22 0 9 6 0.08 +- 0.17 22

No common domains found
Streptomyces sp. H021 282.78 +- 442.40 18 0 10 3 0.09 +- 0.18 18

No common domains found
Streptomyces aurantiacus JA 4570 614.90 +- 1353.85 14 0 9 5 0.07 +- 0.10 14

No common domains found
Streptomyces cellostaticus 230.00 +- 524.84 29 0 13 4 0.12 +- 0.18 29

No common domains found
Kitasatospora xanthocidica 162.03 +- 172.12 20 0 12 7 0.12 +- 0.26 20

No common domains found
Streptomyces sp. 840.1 105.71 +- 98.03 14 0 6 1 0.11 +- 0.20 14

No common domains found
Streptomyces sp. DUT11 179.34 +- 150.73 25 0 13 5 0.11 +- 0.20 25

No common domains found
Streptomyces sp. Root1295 213.59 +- 393.91 19 0 7 3 0.11 +- 0.17 19

No common domains found
Streptomyces flaveus 198.32 +- 302.09 23 0 5 0 0.11 +- 0.22 23

No common domains found
Streptomyces albidoflavus 103.17 +- 110.04 11 0 4 5 0.13 +- 0.11 11

No common domains found
Streptomyces sp. NBRC 109436 121.09 +- 96.51 18 0 6 3 0.09 +- 0.17 18

No common domains found
Streptomyces sp. SBT349 171.35 +- 184.96 15 0 4 2 0.08 +- 0.14 15

No common domains found
Streptomyces tateyamensis 142.56 +- 190.69 13 0 2 1 0.11 +- 0.20 13

No common domains found
Streptomyces sp. AmelKG-D3 133.01 +- 264.10 25 0 15 3 0.09 +- 0.17 25

No common domains found
Streptomyces sp. CB01635 260.10 +- 356.79 37 0 4 2 0.07 +- 0.13 37

No common domains found
Streptomyces hundungensis 368.36 +- 367.13 22 0 8 1 0.05 +- 0.13 22

No common domains found
Streptomyces sp. ADI96-02 441.13 +- 445.69 10 0 4 2 0.08 +- 0.20 10

No common domains found
Streptomyces cacaoi subsp. cacaoi 308.20 +- 264.87 6 0 1 1 0.06 +- 0.16 6 1

PF00005 (3/6) ABC transporter
Streptomyces recifensis 83.03 +- 140.76 5 0 0 0 0.10 +- 0.12 5

No common domains found
Streptomyces sp. CC71 106.19 +- 165.34 8 0 3 0 0.11 +- 0.19 8

No common domains found
Streptomyces sp. 57 572.46 +- 1207.50 12 0 1 2 0.06 +- 0.14 12

No common domains found
Streptomyces sp. 111WW2 140.82 +- 146.52 9 0 3 1 0.10 +- 0.17 9

No common domains found
Streptomyces kasugaensis 473.13 +- 657.52 23 0 9 4 0.05 +- 0.12 23

No common domains found
Streptomyces sp. Tue 6075 120.66 +- 81.89 9 0 4 3 0.11 +- 0.12 9

No common domains found
Streptomyces sp. JS01 312.96 +- 707.71 21 0 4 3 0.10 +- 0.18 21

No common domains found
Streptomyces violaceoruber 95.41 +- 98.56 14 0 6 5 0.12 +- 0.19 14

No common domains found
Streptomyces sp. di50b 168.08 +- 136.34 6 0 2 2 0.13 +- 0.23 6

No common domains found
Streptomyces sp. TSRI0261 244.74 +- 291.87 22 0 13 4 0.11 +- 0.17 22

No common domains found
Streptomyces sp. NRRL S-1813 446.53 +- 635.37 15 0 4 2 0.10 +- 0.20 15

No common domains found
Streptomyces jeddahensis 241.53 +- 368.35 37 0 5 1 0.10 +- 0.19 37

No common domains found
Streptomyces roseoverticillatus 196.49 +- 165.26 9 0 5 0 0.09 +- 0.19 9

No common domains found
Streptomyces malaysiensis 191.01 +- 258.48 21 0 3 1 0.11 +- 0.17 21

No common domains found
Streptomyces albidoflavus 123.62 +- 109.63 8 0 3 4 0.11 +- 0.17 8

No common domains found
Streptomyces sp. NRRL F-5917 132.30 +- 115.77 12 0 5 3 0.04 +- 0.08 12

No common domains found
Streptomyces sp. NBRC 110035 237.51 +- 250.97 14 0 5 1 0.08 +- 0.16 14

No common domains found
Streptomyces griseus subsp. rhodochrous 99.95 +- 113.97 12 0 4 5 0.11 +- 0.20 12

No common domains found
Streptomyces corynorhini 145.38 +- 179.74 10 0 2 3 0.07 +- 0.12 10

No common domains found
Streptomyces sp. DpondAA-E10 135.22 +- 121.02 13 0 4 0 0.11 +- 0.23 13

No common domains found
Streptomyces bingchenggensis BCW-1 274.25 +- 307.38 46 0 18 3 0.07 +- 0.17 46

No common domains found
Streptomyces sp. WMMB 714 271.36 +- 393.16 14 0 8 1 0.08 +- 0.15 14 1

PF00005 (8/14) ABC transporter
Streptomyces rimosus subsp. rimosus 161.22 +- 293.87 20 0 7 5 0.09 +- 0.13 20

No common domains found
Streptomyces sp. CNQ766 275.74 +- 342.43 17 0 8 1 0.09 +- 0.19 17

No common domains found
Streptomyces sp. ST1015 175.55 +- 120.10 15 0 1 2 0.06 +- 0.10 15

No common domains found
Streptomyces rimosus subsp. rimosus 173.70 +- 383.61 15 0 7 3 0.12 +- 0.16 15

No common domains found
Streptomyces sp. FxanaD5 142.73 +- 119.80 5 0 1 1 0.11 +- 0.13 5

No common domains found
Streptomyces pathocidini 224.29 +- 134.46 6 0 0 0 0.08 +- 0.22 6

No common domains found
Streptomyces viridifaciens 324.86 +- 625.22 36 0 13 5 0.08 +- 0.16 36

No common domains found
Streptomyces sp. WAC 06783 142.62 +- 189.72 19 0 6 3 0.09 +- 0.15 19

No common domains found
Streptomyces sp. B29(2018) 157.61 +- 147.82 9 0 3 3 0.11 +- 0.14 9

No common domains found
Streptomyces sp. TLI_053 286.60 +- 338.54 22 0 11 8 0.05 +- 0.12 22

No common domains found
Streptomyces bikiniensis 203.60 +- 202.05 9 0 2 0 0.07 +- 0.19 9

No common domains found
Streptomyces aureus 180.98 +- 191.07 17 0 3 1 0.08 +- 0.12 17

No common domains found
Streptomyces sp. 73 196.48 +- 306.80 23 0 4 1 0.10 +- 0.17 23

No common domains found
Streptomyces collinus Tu 365 100.89 +- 61.76 9 0 7 1 0.08 +- 0.19 9 4

PF07690 (6/9) Major Facilitator Superfamily
TIGR01733 (5/9) amino acid adenylation domain
PF13193 (5/9) AMP-binding enzyme C-terminal domain
PF00501 (5/9) AMP-binding enzyme
Streptomyces albus subsp. albus 334.92 +- 428.47 23 0 12 4 0.05 +- 0.11 23

No common domains found
Streptomyces sp. WM6386 196.56 +- 196.65 16 0 2 1 0.10 +- 0.18 16

No common domains found
Streptomyces sp. NRRL F-4707 20.78 +- 9.57 3 0 1 0 0.16 +- 0.07 3

No common domains found
Streptomyces europaeiscabiei 161.76 +- 277.80 20 0 5 3 0.12 +- 0.20 20

No common domains found
Streptomyces aureus 119.39 +- 145.40 7 0 2 0 0.14 +- 0.16 7

No common domains found
Streptomyces galbus 242.49 +- 514.10 28 0 6 2 0.10 +- 0.16 28

No common domains found
Streptomyces sp. B9173 133.07 +- 228.15 16 0 0 0 0.11 +- 0.20 16

No common domains found
Streptomyces vitaminophilus 199.51 +- 181.47 20 0 8 2 0.07 +- 0.17 20

No common domains found
Streptomyces sp. NRRL F-3273 117.24 +- 123.29 14 0 5 4 0.10 +- 0.18 14

No common domains found
Streptomyces lavendulae subsp. lavendulae 569.51 +- 1144.45 19 0 8 2 0.07 +- 0.17 19

No common domains found
Streptomyces sp. MUSC 1 280.41 +- 369.60 38 0 10 4 0.08 +- 0.16 38

No common domains found
Streptomyces lincolnensis 274.01 +- 494.44 28 0 4 1 0.08 +- 0.17 28

No common domains found
Streptomyces sp. CNQ-525 467.59 +- 713.56 20 0 7 1 0.09 +- 0.21 20 1

PF00005 (10/20) ABC transporter
Streptomyces sp. CB00316 312.35 +- 603.99 13 0 7 2 0.13 +- 0.19 13

No common domains found
Streptomyces sp. W007 87.42 +- 61.17 10 0 5 2 0.11 +- 0.14 10

No common domains found
Streptomyces rapamycinicus NRRL 5491 248.81 +- 297.16 38 0 8 1 0.07 +- 0.16 38

No common domains found
Streptomyces scabiei 164.10 +- 202.73 14 0 1 2 0.07 +- 0.10 14

No common domains found
Streptomyces xiamenensis 169.92 +- 259.93 12 0 2 0 0.11 +- 0.21 12

No common domains found
Streptomyces sp. Ag109_G2-15 158.04 +- 241.56 20 0 4 2 0.12 +- 0.19 20

No common domains found
Streptomyces sp. NRRL S-340 156.12 +- 153.08 10 0 2 3 0.10 +- 0.13 10

No common domains found
Streptomyces agglomeratus 570.96 +- 1139.99 23 0 8 3 0.08 +- 0.20 23

No common domains found
Streptomyces hirsutus 169.20 +- 212.24 11 0 0 1 0.09 +- 0.13 11

No common domains found
Streptomyces sp. PsTaAH-124 116.48 +- 123.66 6 0 0 0 0.08 +- 0.09 6

No common domains found
Streptomyces europaeiscabiei 115.81 +- 105.57 15 0 0 0 0.09 +- 0.11 15

No common domains found
Streptomyces acidiscabies 368.20 +- 418.43 31 0 6 1 0.07 +- 0.19 31

No common domains found
Streptomyces sp. AZ1-7 335.62 +- 416.21 25 0 9 3 0.08 +- 0.20 25

No common domains found
Streptomyces sp. XY006 100.98 +- 93.14 10 0 3 1 0.12 +- 0.15 10

No common domains found
Streptomyces griseus subsp. rhodochrous 79.53 +- 73.99 14 0 5 5 0.14 +- 0.24 14

No common domains found
Streptomyces sp. Z022 235.71 +- 247.90 15 0 6 1 0.06 +- 0.12 15

No common domains found
Streptomyces sp. TSRI0384-2 93.64 +- 79.64 9 0 5 1 0.10 +- 0.15 9

No common domains found
Streptomyces sp. AmelKG-A3 340.40 +- 479.83 12 0 4 1 0.05 +- 0.12 12

No common domains found
Streptomyces sp. Root1310 68.81 +- 80.43 17 0 1 1 0.13 +- 0.24 17

No common domains found
Streptomyces scabiei 87.22 242.55 +- 498.42 22 0 7 0 0.08 +- 0.14 22

No common domains found
Streptomyces wedmorensis 275.36 +- 318.84 23 0 6 1 0.07 +- 0.14 23

No common domains found
Streptomyces griseus 116.74 +- 98.52 7 0 2 3 0.12 +- 0.16 7

No common domains found
Streptomyces cavernae 245.33 +- 325.12 32 0 4 1 0.09 +- 0.17 32

No common domains found
Streptomyces glauciniger 393.08 +- 502.04 17 0 2 1 0.07 +- 0.15 17

No common domains found
Streptomyces guanduensis 362.97 +- 913.61 23 0 2 2 0.10 +- 0.17 23

No common domains found
Streptomyces sp. PAN_FS17 170.55 +- 369.52 18 0 1 4 0.12 +- 0.14 18

No common domains found
Streptomyces sp. Ag82_G5-5 203.19 +- 284.52 29 0 7 2 0.10 +- 0.21 29

No common domains found
Streptomyces sp. KhCrAH-43 102.84 +- 160.82 8 0 2 2 0.10 +- 0.17 8

No common domains found
Streptomyces sp. TN58 1132.25 +- 1792.66 10 0 7 2 0.05 +- 0.12 10 1

PF00005 (6/10) ABC transporter
Streptomyces scabiei 138.45 +- 118.03 13 0 0 0 0.05 +- 0.06 13

No common domains found
Streptomyces sp. LAM7114 482.21 +- 619.32 28 0 3 0 0.07 +- 0.18 28

No common domains found
Streptomyces cyaneogriseus subsp. noncyanogenus 284.21 +- 437.49 13 0 3 2 0.10 +- 0.17 13

No common domains found
Streptomyces sp. DpondAA-F4a 237.20 +- 271.74 10 0 2 0 0.11 +- 0.21 10

No common domains found
Streptomyces xylophagus 182.90 +- 250.76 35 0 2 1 0.08 +- 0.17 35

No common domains found
Streptomyces sp. NRRL WC-3723 215.29 +- 244.13 20 0 4 2 0.07 +- 0.12 20

No common domains found
Streptomyces hygroscopicus subsp. jinggangensis 5008 259.99 +- 411.29 26 0 10 2 0.09 +- 0.19 26

No common domains found
Embleya scabrispora 103.00 +- 113.44 17 0 7 4 0.12 +- 0.25 17

No common domains found
Streptomyces hygroscopicus 474.15 +- 871.70 47 0 14 0 0.06 +- 0.15 47

No common domains found
Streptomyces globosus 234.87 +- 346.24 15 0 8 4 0.10 +- 0.24 15

No common domains found
Streptomyces sp. NRRL B-24720 380.57 +- 575.19 24 0 3 2 0.08 +- 0.18 24

No common domains found
Streptomyces sp. NRRL F-2890 217.73 +- 327.40 12 0 4 1 0.14 +- 0.23 12

No common domains found
Streptomyces sp. CNR698 374.71 +- 598.66 10 0 4 2 0.07 +- 0.17 10

No common domains found
Streptomyces leeuwenhoekii 281.52 +- 393.60 12 0 3 0 0.10 +- 0.19 12 1

PF07690 (6/12) Major Facilitator Superfamily
Streptomyces pyridomyceticus 752.40 +- 1559.10 12 0 5 3 0.10 +- 0.22 12

No common domains found
Streptomyces sp. SM17 89.44 +- 57.55 9 0 3 3 0.15 +- 0.19 9

No common domains found
Streptomyces erythrochromogenes 135.17 +- 95.83 9 0 1 0 0.07 +- 0.15 9 1

PF07690 (6/9) Major Facilitator Superfamily
Streptomyces scopuliridis RB72 322.19 +- 321.16 19 0 6 0 0.09 +- 0.19 19

No common domains found
Streptomyces albus 183.18 +- 139.21 12 0 5 4 0.08 +- 0.21 12

No common domains found
Streptomyces sp. LUP30 272.44 +- 372.02 9 0 3 1 0.07 +- 0.17 9

No common domains found
Streptomyces sp. TSRI0281 338.96 +- 785.45 29 0 12 7 0.06 +- 0.15 29

No common domains found
Streptomyces sp. ADI92-24 236.35 +- 421.31 22 0 8 2 0.10 +- 0.19 22

No common domains found
Streptomyces albidoflavus 94.69 +- 87.71 12 0 2 3 0.12 +- 0.19 12

No common domains found
Streptomyces sp. WM6349 108.77 +- 111.05 17 0 8 3 0.08 +- 0.17 17

No common domains found
Streptomyces sp. S063 150.00 +- 340.84 10 0 3 1 0.16 +- 0.16 10

No common domains found
Streptomyces griseoviridis 292.97 +- 546.07 23 0 9 2 0.09 +- 0.18 23

No common domains found
Streptomyces sp. 150FB 330.61 +- 383.50 26 0 11 0 0.07 +- 0.14 26

No common domains found
Streptomyces sp. SM10 366.62 +- 952.38 17 0 4 2 0.11 +- 0.18 17

No common domains found
Streptomyces sp. di188 186.20 +- 170.80 7 0 1 1 0.13 +- 0.23 7

No common domains found
Streptomyces anulatus 228.39 +- 254.46 17 0 7 4 0.08 +- 0.17 17

No common domains found
Streptomyces canus 225.10 +- 288.94 37 0 3 2 0.09 +- 0.17 37

No common domains found
Streptomyces griseoruber 489.07 +- 616.15 22 0 5 2 0.05 +- 0.14 22

No common domains found
Streptomyces sp. HB202 182.90 +- 245.52 13 0 6 4 0.11 +- 0.13 13

No common domains found
Streptomyces cavourensis 128.92 +- 135.80 17 0 6 4 0.10 +- 0.19 17

No common domains found
Streptomyces mirabilis 114.09 +- 108.79 30 0 4 1 0.11 +- 0.22 30

No common domains found
Streptomyces sp. 1222.2 171.70 +- 243.24 21 0 7 0 0.09 +- 0.13 21

No common domains found
Streptomyces sp. 13K301 210.18 +- 218.29 15 0 2 2 0.10 +- 0.18 15

No common domains found
Streptomyces vinaceus 428.09 +- 753.84 7 0 2 2 0.10 +- 0.18 7

No common domains found
Streptomyces sp. MUSC 93 391.72 +- 619.28 10 0 1 1 0.05 +- 0.13 10

No common domains found
Streptomyces sp. NRRL F-525 235.32 +- 296.88 34 0 4 2 0.08 +- 0.14 34

No common domains found
Streptomyces hygroscopicus subsp. jinggangensis TL01 305.22 +- 403.43 26 0 12 2 0.07 +- 0.17 26

No common domains found
Streptomyces sp. EN27 308.84 +- 705.05 18 0 5 2 0.12 +- 0.18 18

No common domains found
Streptomyces sp. SM11 127.79 +- 125.99 14 0 4 2 0.11 +- 0.17 14

No common domains found
Streptomyces sp. LaPpAH-199 101.62 +- 79.40 13 0 4 4 0.13 +- 0.21 13

No common domains found
Streptomyces sp. CB02488 344.91 +- 762.46 21 0 4 0 0.11 +- 0.24 21

No common domains found
Streptomyces californicus 107.44 +- 85.11 17 0 5 5 0.09 +- 0.15 17

No common domains found
Streptomyces sp. SPB074 303.83 +- 418.05 9 0 1 0 0.06 +- 0.10 9

No common domains found
Streptomyces acidiscabies 228.14 +- 246.06 27 0 3 1 0.08 +- 0.19 27

No common domains found
Streptomyces sp. 70 665.13 +- 2533.50 31 0 9 5 0.11 +- 0.20 31

No common domains found
Streptomyces rimosus subsp. rimosus 241.61 +- 570.02 21 0 10 4 0.10 +- 0.21 21

No common domains found
Streptomyces exfoliatus 154.44 +- 168.57 15 0 6 4 0.11 +- 0.21 15

No common domains found
Streptomyces prasinus 212.21 +- 254.45 9 0 2 1 0.04 +- 0.07 9

No common domains found
Streptomyces sp. 2333.5 345.58 +- 480.13 27 0 12 6 0.06 +- 0.15 27

No common domains found
Streptomyces fradiae 227.65 +- 159.35 2 0 1 1 0.07 +- 0.24 2 8

PF13471 (1/2) Transglutaminase-like superfamily
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (1/2) TadE-like protein
PF00733 (1/2) Asparagine synthase
PF00691 (1/2) OmpA family
PF00482 (1/2) Type II secretion system (T2SS), protein F
PF00437 (1/2) Type II/IV secretion system protein
PF00005 (1/2) ABC transporter
Streptomyces abyssalis 135.16 +- 188.07 13 0 4 0 0.10 +- 0.18 13

No common domains found
Streptomyces canus 299MFChir4.1 299.91 +- 402.02 44 0 7 2 0.09 +- 0.17 44

No common domains found
Streptomyces dioscori 348.75 +- 536.42 23 0 8 2 0.10 +- 0.18 23

No common domains found
Streptomyces atriruber 93.91 +- 53.91 11 0 3 2 0.12 +- 0.14 11

No common domains found
Streptomyces sp. IB2014 011-1 135.21 +- 200.39 11 0 5 3 0.13 +- 0.13 11

No common domains found
Streptomyces zhaozhouensis 184.11 +- 135.40 14 0 4 1 0.06 +- 0.12 14

No common domains found
Streptomyces sp. NRRL S-475 384.80 +- 480.11 12 0 1 2 0.07 +- 0.10 12

No common domains found
Streptomyces sp. 2114.4 111.96 +- 120.74 17 0 8 5 0.11 +- 0.20 17

No common domains found
Streptomyces qinglanensis 328.68 +- 753.92 12 0 4 2 0.10 +- 0.21 12

No common domains found
Streptomyces griseus 165.62 +- 147.89 10 0 4 0 0.11 +- 0.22 10

No common domains found
Streptomyces sp. LamerLS-316 705.08 +- 1313.75 6 0 1 1 0.09 +- 0.21 6

No common domains found
Streptomyces violaceusniger Tu 4113 298.94 +- 492.50 27 0 13 2 0.09 +- 0.18 27

No common domains found
Streptomyces sp. ST1020 113.75 +- 95.27 11 0 0 2 0.08 +- 0.11 11

No common domains found
Streptomyces sp. M10 98.91 +- 132.67 6 0 4 4 0.15 +- 0.17 6 1

PF02624 (3/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
Streptomyces sp. AS58 344.81 +- 317.40 21 0 9 1 0.06 +- 0.14 21

No common domains found
Streptomyces sp. AA1529 561.26 +- 1224.03 13 0 5 3 0.07 +- 0.14 13

No common domains found
Streptomyces sp. PpalLS-921 208.26 +- 115.40 6 0 1 2 0.09 +- 0.22 6

No common domains found
Streptomyces alboflavus 260.30 +- 268.52 22 0 10 3 0.07 +- 0.15 22

No common domains found
Streptomyces sp. NRRL F-3218 116.90 +- 103.08 12 0 5 4 0.12 +- 0.20 12

No common domains found
Streptomyces iakyrus 402.84 +- 589.94 25 0 6 2 0.07 +- 0.14 25

No common domains found
Streptomyces tsukubensis 108.70 +- 104.28 17 0 0 4 0.12 +- 0.20 17

No common domains found
Streptomyces pseudovenezuelae 299.68 +- 377.11 28 0 7 2 0.08 +- 0.15 28

No common domains found
Streptomyces sp. EN23 189.71 +- 260.15 8 0 2 2 0.15 +- 0.21 8

No common domains found
Streptomyces albus 106.74 +- 50.52 5 0 0 0 0.03 +- 0.06 5

No common domains found
Streptomyces sp. Mg1 521.46 +- 807.94 16 0 5 6 0.05 +- 0.14 16

No common domains found
Streptomyces sp. KS_16 240.92 +- 340.75 23 0 8 4 0.08 +- 0.17 23

No common domains found
Streptomyces sp. NRRL F-5702 95.45 +- 82.36 11 0 3 4 0.11 +- 0.19 11

No common domains found
Streptomyces vinaceus 108.90 +- 105.61 14 0 3 4 0.10 +- 0.16 14

No common domains found
Streptomyces scabiei 104.68 +- 80.88 10 0 0 0 0.07 +- 0.08 10

No common domains found
Streptomyces griseus subsp. griseus 367.74 +- 561.13 30 0 4 0 0.07 +- 0.12 30

No common domains found
Streptomyces uncialis 481.11 +- 547.19 24 0 5 2 0.06 +- 0.16 24

No common domains found
Streptomyces jietaisiensis 234.79 +- 313.55 9 0 2 1 0.09 +- 0.18 9

No common domains found
Streptomyces albidoflavus 145.65 +- 187.87 6 0 2 1 0.08 +- 0.09 6

No common domains found
Streptomyces lincolnensis 171.58 +- 193.35 21 0 4 1 0.09 +- 0.18 21

No common domains found
Streptomyces sampsonii 72.02 +- 66.68 13 0 4 4 0.15 +- 0.19 13

No common domains found
Streptomyces rimosus 102.91 +- 157.18 15 0 6 4 0.12 +- 0.13 15

No common domains found
Streptomyces sp. 96-12 228.06 +- 301.88 10 0 1 0 0.08 +- 0.12 10

No common domains found
Streptomyces cyaneofuscatus 93.58 +- 145.73 8 0 5 4 0.15 +- 0.17 8

No common domains found
Streptomyces lavendulae subsp. lavendulae 152.57 +- 95.57 11 0 8 1 0.10 +- 0.21 11

No common domains found
Streptomyces sp. NRRL S-1521 293.91 +- 370.13 13 0 7 3 0.09 +- 0.20 13

No common domains found
Streptomyces sp. NRRL S-98 154.30 +- 159.82 14 0 7 2 0.10 +- 0.18 14

No common domains found
Streptomyces albulus 324.96 +- 467.45 25 0 12 3 0.05 +- 0.11 25

No common domains found
Streptomyces rimosus R6-500 67.23 +- 61.64 15 0 5 3 0.12 +- 0.13 15

No common domains found
Streptomyces gancidicus BKS 13-15 95.22 +- 66.31 7 0 1 0 0.12 +- 0.15 7

No common domains found
Streptomyces sp. Tu6071 192.73 +- 149.01 8 0 2 0 0.08 +- 0.21 8

No common domains found
Streptomyces sp. WAC04770 967.27 +- 1743.86 14 0 4 3 0.04 +- 0.11 14

No common domains found
Streptomyces sp. HCCB10043 33.64 +- 17.43 3 0 2 0 0.17 +- 0.24 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. DvalAA-21 135.22 +- 121.02 13 0 4 0 0.11 +- 0.23 13

No common domains found
Streptomyces sp. SM12 783.92 +- 958.40 10 0 3 2 0.03 +- 0.07 10

No common domains found
Streptomyces tsukubensis 227.89 +- 331.80 19 0 6 4 0.09 +- 0.21 19

No common domains found
Streptomyces sp. Root369 243.11 +- 339.95 42 0 4 1 0.10 +- 0.18 42

No common domains found
Streptomyces sp. NRRL F-4489 130.42 +- 175.47 13 0 3 2 0.12 +- 0.20 13

No common domains found
Streptomyces sp. WAC 04229 126.20 +- 202.18 6 0 0 0 0.09 +- 0.21 6

No common domains found
Streptomyces rimosus 91.61 +- 89.07 12 0 6 2 0.13 +- 0.16 12

No common domains found
Streptomyces exfoliatus 188.47 +- 193.58 15 0 6 4 0.10 +- 0.18 15

No common domains found
Streptomyces sp. XY152 158.72 +- 214.60 18 0 7 1 0.08 +- 0.14 18

No common domains found
Streptomyces sp. ok210 301.35 +- 577.30 18 0 2 0 0.09 +- 0.20 18

No common domains found
Streptomyces badius 251.06 +- 306.66 14 0 6 3 0.10 +- 0.12 14

No common domains found
Streptomyces sp. F-7 109.88 +- 92.21 10 0 1 2 0.12 +- 0.13 10

No common domains found
Streptomyces spongiicola 292.24 +- 552.30 11 0 5 2 0.10 +- 0.19 11

No common domains found
Streptomyces sp. NEAU-S7GS2 219.55 +- 347.70 17 0 8 4 0.11 +- 0.17 17

No common domains found
Streptomyces sp. NRRL B-1568 195.19 +- 109.04 5 0 1 0 0.06 +- 0.08 5

No common domains found
Streptomyces sp. NBRC 110028 285.90 +- 374.78 23 0 4 2 0.07 +- 0.14 23

No common domains found
Streptomyces sp. Tu 6176 155.12 +- 155.15 11 0 3 1 0.06 +- 0.10 11

No common domains found
Streptomyces rimosus subsp. rimosus 177.08 +- 309.96 21 0 8 5 0.10 +- 0.20 21

No common domains found
Streptomyces globisporus 179.60 +- 263.82 16 0 5 3 0.11 +- 0.17 16

No common domains found
Streptomyces sp. NRRL S-241 204.31 +- 231.26 19 0 9 0 0.08 +- 0.19 19

No common domains found
Streptomyces olivochromogenes 227.84 +- 317.77 31 0 8 3 0.09 +- 0.19 31

No common domains found
Streptomyces sp. DfronAA-171 97.09 +- 74.40 7 0 0 0 0.10 +- 0.16 7 1

PF00528 (4/7) Binding-protein-dependent transport system inner membrane component
Streptomyces albus subsp. albus 110.32 +- 137.74 19 0 8 5 0.12 +- 0.18 19

No common domains found
Streptomyces sp. NRRL WC-3618 257.83 +- 357.69 24 0 5 0 0.10 +- 0.18 24

No common domains found
Streptomyces aidingensis 207.46 +- 155.80 10 0 2 1 0.07 +- 0.19 10

No common domains found
Streptomyces malaysiense 292.47 +- 421.50 7 0 2 0 0.09 +- 0.21 7

No common domains found
Streptomyces albidoflavus 99.53 +- 56.12 7 0 3 2 0.10 +- 0.07 7

No common domains found
Streptomyces sp. BSE7F 188.56 +- 165.06 7 0 1 2 0.13 +- 0.17 7

No common domains found
Streptomyces sp. SAI-083 380.02 +- 649.56 29 0 3 1 0.06 +- 0.12 29

No common domains found
Streptomyces sp. 1222.5 261.38 +- 402.15 13 0 10 3 0.08 +- 0.16 13

No common domains found
Streptomyces sp. NRRL F-5527 317.28 +- 207.66 4 0 1 1 0.07 +- 0.09 4 6

PF13400 (3/4) Putative Flp pilus-assembly TadE/G-like
PF07811 (3/4) TadE-like protein
PF00482 (3/4) Type II secretion system (T2SS), protein F
PF00437 (3/4) Type II/IV secretion system protein
PF13814 (2/4) Replication-relaxation
PF01476 (2/4) LysM domain
Streptomyces albulus 414.62 +- 552.19 27 0 13 2 0.06 +- 0.15 27

No common domains found
Streptomyces nanshensis 129.31 +- 136.21 15 0 3 3 0.10 +- 0.20 15

No common domains found
Streptomyces sp. NRRL F-6491 269.73 +- 303.86 13 0 1 1 0.08 +- 0.18 13

No common domains found
Streptomyces sp. 3212.5 319.23 +- 557.38 28 0 12 3 0.10 +- 0.20 28

No common domains found
Streptomyces sp. RTd22 149.07 +- 136.29 31 0 6 3 0.09 +- 0.18 31

No common domains found
Streptomyces sp. NRRL S-481 201.04 +- 348.95 18 0 4 1 0.11 +- 0.17 18

No common domains found
Streptomyces sp. NRRL F-4428 775.20 +- 1731.55 9 0 8 2 0.08 +- 0.14 9

No common domains found
Streptomyces sp. NRRL F-6674 524.45 +- 1131.29 19 0 5 4 0.07 +- 0.15 19

No common domains found
Streptomyces sp. endophyte_N2 130.03 +- 124.94 18 0 9 4 0.08 +- 0.17 18

No common domains found
Streptomyces flaveolus 133.91 +- 106.52 20 0 5 0 0.10 +- 0.19 20

No common domains found
Streptomyces antibioticus 209.34 +- 360.93 22 0 4 1 0.09 +- 0.15 22

No common domains found
Streptomyces sp. ADI95-16 972.12 +- 987.53 19 0 8 7 0.04 +- 0.14 19

No common domains found
Streptomyces sp. Ncost-T6T-1 317.23 +- 550.68 14 0 2 2 0.12 +- 0.22 14

No common domains found
Streptomyces griseoaurantiacus M045 180.31 +- 273.86 13 0 2 1 0.11 +- 0.18 13

No common domains found
Streptomyces coelicoflavus ZG0656 589.68 +- 1320.14 10 0 2 1 0.08 +- 0.14 10

No common domains found
Streptomyces sp. NRRL S-474 207.84 +- 235.87 13 0 4 2 0.11 +- 0.16 13

No common domains found
Streptomyces sp. CFMR 7 228.76 +- 500.06 25 0 11 3 0.11 +- 0.16 25

No common domains found
Streptomyces sp. M41(2017) 153.21 +- 188.06 21 0 5 2 0.13 +- 0.21 21

No common domains found
Streptomyces rubrolavendulae 156.37 +- 153.37 7 0 3 2 0.09 +- 0.13 7

No common domains found
Streptomyces albireticuli 496.11 +- 505.75 12 0 3 1 0.05 +- 0.18 12

No common domains found
Streptomyces caeruleatus 222.65 +- 260.97 28 0 6 1 0.09 +- 0.17 28

No common domains found
Streptomyces sp. NEAU-SSA 1 281.53 +- 350.76 38 0 3 2 0.09 +- 0.19 38

No common domains found
Streptomyces sp. Root264 561.99 +- 1004.45 27 0 5 3 0.09 +- 0.19 27

No common domains found
Streptomyces ruber 250.22 +- 346.17 25 0 10 2 0.07 +- 0.15 25

No common domains found
Streptomyces graminis 99.28 +- 65.37 14 0 6 4 0.07 +- 0.16 14

No common domains found
Streptomyces sp. NRRL F-5681 117.19 +- 112.66 14 0 6 5 0.12 +- 0.20 14

No common domains found
Streptomyces sp. AW19M42 447.59 +- 689.93 19 0 7 3 0.10 +- 0.20 19

No common domains found
Streptomyces cavourensis 162.04 +- 163.41 20 0 8 3 0.10 +- 0.18 20

No common domains found
Streptomyces bungoensis 488.90 +- 1382.30 14 0 6 2 0.11 +- 0.19 14

No common domains found
Streptomyces sp. st77 264.00 +- 209.69 12 0 2 3 0.07 +- 0.14 12

No common domains found
Streptomyces fodineus 652.50 +- 1370.93 20 0 8 4 0.09 +- 0.20 20

No common domains found
Streptomyces sp. ATexAB-D23 299.70 +- 503.96 17 0 12 6 0.11 +- 0.21 17

No common domains found
Streptomyces albidoflavus 98.61 +- 94.62 9 0 3 4 0.10 +- 0.14 9

No common domains found
Streptomyces sp. NRRL B-11253 156.36 +- 124.45 18 0 4 2 0.08 +- 0.19 18

No common domains found
Streptomyces ipomoeae 91-03 274.43 +- 502.80 21 0 4 4 0.08 +- 0.18 21

No common domains found
Streptomyces sp. CB02009 428.97 +- 632.75 21 0 9 5 0.08 +- 0.18 21

No common domains found
Streptomyces sp. NRRL B-3648 184.52 +- 219.46 17 0 6 1 0.09 +- 0.19 17

No common domains found
Streptomyces qinglanensis 556.12 +- 1580.99 12 0 4 2 0.07 +- 0.13 12

No common domains found
Streptomyces sp. ADI91-18 597.64 +- 839.07 16 0 6 4 0.06 +- 0.17 16

No common domains found
Streptomyces sp. WAC 01420 328.86 +- 339.93 17 0 4 0 0.07 +- 0.15 17

No common domains found
Streptomyces sp. NRRL WC-3701 187.75 +- 306.76 18 0 7 5 0.08 +- 0.14 18

No common domains found
Streptomyces sampsonii 104.05 +- 117.93 11 0 4 3 0.13 +- 0.18 11

No common domains found
Streptomyces glaucescens 175.46 +- 102.80 6 0 3 3 0.13 +- 0.21 6 1

PF00005 (3/6) ABC transporter
Streptomyces fulvoviolaceus 436.49 +- 862.54 40 0 4 2 0.07 +- 0.16 40

No common domains found
Streptomyces sp. CCM_MD2014 150.22 +- 265.10 11 0 1 1 0.10 +- 0.15 11

No common domains found
Streptomyces sp. 69 191.90 +- 235.09 10 0 1 1 0.07 +- 0.13 10

No common domains found
Streptomyces sp. BpilaLS-43 255.14 +- 258.42 10 0 6 0 0.11 +- 0.21 10

No common domains found
Embleya hyalina 152.23 +- 136.21 23 0 9 5 0.09 +- 0.17 23

No common domains found
Streptomyces sp. PCS3-D2 283.74 +- 534.77 11 0 6 1 0.12 +- 0.24 11

No common domains found
Streptomyces gilvosporeus 175.99 +- 149.33 18 0 2 3 0.08 +- 0.15 18

No common domains found
Streptomyces sp. B188M101 223.26 +- 340.30 15 0 4 3 0.11 +- 0.16 15

No common domains found
Streptomyces tricolor 127.21 +- 105.95 6 0 3 1 0.12 +- 0.21 6

No common domains found
Streptomyces albidoflavus 95.45 +- 92.69 13 0 5 4 0.10 +- 0.14 13

No common domains found
Streptomyces sp. CNH099 234.35 +- 502.14 15 0 2 1 0.10 +- 0.20 15

No common domains found
Streptomyces sp. CB02056 185.92 +- 169.63 17 0 13 6 0.08 +- 0.19 17

No common domains found
Streptomyces canus 263.11 +- 374.21 38 0 3 3 0.11 +- 0.16 38

No common domains found
Streptomyces sp. MK-45 319.85 +- 784.41 35 0 12 1 0.12 +- 0.19 35

No common domains found
Streptomyces sp. PgraA7 130.92 +- 154.87 13 0 3 3 0.11 +- 0.14 13

No common domains found
Streptomyces sp. 62 229.60 +- 234.25 21 0 4 4 0.08 +- 0.15 21

No common domains found
Streptomyces sp. DpondAA-F4 124.36 +- 103.46 10 0 3 0 0.10 +- 0.18 10

No common domains found
Streptomyces sp. DvalAA-14 199.00 +- 145.82 12 0 0 0 0.08 +- 0.17 12

No common domains found
Streptomyces sp. TAA486 267.80 +- 292.56 26 0 3 3 0.07 +- 0.16 26

No common domains found
Streptomyces sp. GBA 94-10 83.17 +- 57.90 13 0 8 4 0.11 +- 0.17 13

No common domains found
Streptomyces sp. fd1-xmd 303.19 +- 460.33 12 0 5 1 0.10 +- 0.21 12

No common domains found
Streptomyces sp. NRRL S-515 338.63 +- 434.70 13 0 3 0 0.07 +- 0.18 13

No common domains found
Streptomyces griseoflavus Tu4000 145.09 +- 103.94 10 0 2 1 0.10 +- 0.18 10

No common domains found
Streptomyces rubidus 299.14 +- 267.72 10 0 2 1 0.04 +- 0.06 10

No common domains found
Streptomyces sp. WAC05292 58.48 +- 0.00 1 0 1 0 0.17 +- 0.26 1 19

TIGR02814 (1/1) PfaD family protein
TIGR01733 (1/1) amino acid adenylation domain
TIGR00223 (1/1) aspartate 1-decarboxylase
TIGR00128 (1/1) malonyl CoA-acyl carrier protein transacylase
PF14200 (1/1) Ricin-type beta-trefoil lectin domain-like
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08241 (1/1) Methyltransferase domain
PF05532 (1/1) CsbD-like
PF05270 (1/1) Alpha-L-arabinofuranosidase B (ABFB) domain
PF03664 (1/1) Glycosyl hydrolase family 62
PF02261 (1/1) Aspartate decarboxylase
PF00891 (1/1) O-methyltransferase domain
PF00698 (1/1) Acyl transferase domain
PF00668 (1/1) Condensation domain
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00331 (1/1) Glycosyl hydrolase family 10
PF00067 (1/1) Cytochrome P450
Streptomyces sp. CB02261 189.11 +- 205.07 18 0 7 3 0.13 +- 0.20 18

No common domains found
Streptomyces seoulensis 97.44 +- 139.16 7 0 2 0 0.17 +- 0.28 7

No common domains found
Streptomyces sp. ZEA17I 130.00 +- 0.00 1 0 0 0 0.03 +- 0.03 1 2

PF04299 (1/1) Putative FMN-binding domain
PF01494 (1/1) FAD binding domain
Streptomyces sp. HGB0020 310.85 +- 550.94 29 0 4 3 0.08 +- 0.15 29

No common domains found
Streptomyces albidoflavus 82.50 +- 71.54 9 0 4 3 0.14 +- 0.14 9

No common domains found
Streptomyces sp. CB00072 174.59 +- 237.29 14 0 4 3 0.09 +- 0.15 14

No common domains found
Streptomyces sp. NRRL S-1314 248.24 +- 241.09 8 0 3 2 0.08 +- 0.11 8

No common domains found
Streptomyces showdoensis 601.28 +- 941.50 13 0 4 1 0.06 +- 0.12 13

No common domains found
Streptomyces sp. CB01883 172.68 +- 199.36 14 0 5 1 0.12 +- 0.18 14

No common domains found
Streptomyces flavochromogenes 300.95 +- 305.58 18 0 8 5 0.08 +- 0.16 18

No common domains found
Streptomyces sp. CB02115 103.47 +- 119.65 14 0 5 4 0.12 +- 0.15 14

No common domains found
Streptomyces sp. S10(2018) 82.68 +- 63.22 5 0 2 1 0.11 +- 0.17 5 1

PF00005 (3/5) ABC transporter
Streptomyces albus 101.54 +- 72.35 5 0 2 3 0.14 +- 0.09 5 1

PF02624 (3/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
Streptomyces pseudogriseolus 82.77 +- 57.96 2 0 1 1 0.14 +- 0.08 2 10

TIGR04451 (1/2) lantipeptide, SCO0268 family
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (1/2) TadE-like protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF01042 (1/2) Endoribonuclease L-PSP
PF00482 (1/2) Type II secretion system (T2SS), protein F
PF00437 (1/2) Type II/IV secretion system protein
Streptomyces sp. NRRL WC-3725 150.20 +- 103.59 24 0 7 1 0.10 +- 0.20 24

No common domains found
Streptomyces sp. NRRL WC-3549 181.00 +- 282.55 12 0 2 0 0.11 +- 0.22 12

No common domains found
Streptomyces sp. WAC 05379 146.64 +- 162.45 16 0 4 2 0.11 +- 0.16 16

No common domains found
Streptomyces sp. B226SN101 176.10 +- 201.11 11 0 4 4 0.12 +- 0.20 11

No common domains found
Streptomyces sp. WAC 01529 386.82 +- 566.63 22 0 11 3 0.06 +- 0.16 22

No common domains found
Streptomyces sp. NRRL F-5053 168.14 +- 200.71 7 0 5 1 0.11 +- 0.23 7

No common domains found
Streptomyces kanamyceticus 280.99 +- 443.32 15 0 5 4 0.11 +- 0.17 15

No common domains found
Streptomyces albus 112.47 +- 73.76 8 0 1 2 0.05 +- 0.15 8

No common domains found
Streptomyces scabiei 125.96 +- 183.43 14 0 7 1 0.09 +- 0.18 14

No common domains found
Streptomyces sp. st115 360.23 +- 622.88 21 0 6 2 0.09 +- 0.17 21

No common domains found
Streptomyces violaceorubidus 173.19 +- 240.96 8 0 1 1 0.12 +- 0.19 8

No common domains found
Streptomyces xanthophaeus 389.04 +- 644.14 19 0 8 3 0.10 +- 0.24 19

No common domains found
Streptomyces griseus 82.82 +- 65.88 12 0 7 1 0.11 +- 0.17 12

No common domains found
Streptomyces sp. QL37 194.93 +- 281.36 16 0 6 3 0.11 +- 0.23 16

No common domains found
Streptomyces prasinopilosus 125.31 +- 153.06 4 0 1 1 0.05 +- 0.06 4 3

PF07690 (2/4) Major Facilitator Superfamily
PF01408 (2/4) Oxidoreductase family, NAD-binding Rossmann fold
PF00550 (2/4) Phosphopantetheine attachment site
Streptomyces sp. CNT360 177.99 +- 276.75 15 0 4 2 0.09 +- 0.19 15

No common domains found
Streptomyces rimosus subsp. rimosus 60.91 +- 64.85 13 0 3 2 0.13 +- 0.12 13

No common domains found
Streptomyces sp. M2 243.05 +- 270.73 31 0 6 2 0.10 +- 0.19 31

No common domains found
Streptomyces celluloflavus 341.40 +- 428.36 25 0 8 4 0.06 +- 0.13 25

No common domains found
Streptomyces sp. PT12 191.18 +- 192.63 14 0 7 4 0.11 +- 0.21 14

No common domains found
Streptomyces sp. WAC 06725 130.97 +- 123.88 10 0 3 1 0.09 +- 0.19 10

No common domains found
Streptomyces rimosus subsp. rimosus 245.43 +- 343.60 13 0 4 2 0.07 +- 0.18 13

No common domains found
Streptomyces fulvoviridis 200.43 +- 217.65 21 0 6 1 0.09 +- 0.17 21

No common domains found
Streptomyces sp. DS1-2 376.56 +- 493.56 25 0 8 3 0.08 +- 0.20 25

No common domains found
Streptomyces ruber 172.29 +- 203.90 15 0 5 2 0.08 +- 0.15 15

No common domains found
Streptomyces sp. CT34 233.89 +- 242.80 16 0 9 2 0.07 +- 0.18 16

No common domains found
Streptomyces sp. 3211 197.80 +- 285.55 16 0 9 1 0.11 +- 0.23 16

No common domains found
Streptomyces sp. S8 307.98 +- 698.12 25 0 12 5 0.11 +- 0.21 25

No common domains found
Streptomyces sp. NBRC 110027 180.35 +- 217.84 35 0 11 5 0.08 +- 0.18 35

No common domains found
Streptomyces caelestis 155.66 +- 160.17 16 0 6 1 0.09 +- 0.17 16

No common domains found
Streptomyces griseorubiginosus 275.91 +- 415.48 27 0 5 1 0.08 +- 0.13 27

No common domains found
Streptomyces lydicus 262.89 +- 554.94 18 0 5 3 0.10 +- 0.19 18

No common domains found
Streptomyces bacillaris 128.83 +- 151.99 19 0 10 4 0.12 +- 0.20 19

No common domains found
Streptomyces sp. TLI_55 104.02 +- 119.40 28 0 4 3 0.11 +- 0.17 28

No common domains found
Streptomyces rishiriensis 137.35 +- 206.57 19 0 6 1 0.14 +- 0.19 19

No common domains found
Streptomyces sp. 2114.2 159.71 +- 201.77 9 0 5 1 0.10 +- 0.17 9

No common domains found
Streptomyces europaeiscabiei 134.48 +- 166.30 18 0 1 0 0.10 +- 0.14 18

No common domains found
Streptomyces rimosus subsp. rimosus 161.16 +- 297.18 19 0 8 4 0.11 +- 0.18 19

No common domains found
Streptomyces thermoautotrophicus 126.58 +- 119.63 10 0 1 0 0.11 +- 0.23 10

No common domains found
Streptomyces flavidovirens DSM 40150 352.81 +- 342.57 12 0 6 1 0.07 +- 0.21 12

No common domains found
Streptomyces sp. 46 181.97 +- 310.83 18 0 4 1 0.09 +- 0.16 18

No common domains found
Streptomyces albidoflavus 164.69 +- 150.25 12 0 2 4 0.09 +- 0.18 12

No common domains found
Streptomyces diastaticus 53.29 +- 26.62 4 0 0 0 0.22 +- 0.32 4 4

PF13400 (2/4) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/4) TadE-like protein
PF00482 (2/4) Type II secretion system (T2SS), protein F
PF00437 (2/4) Type II/IV secretion system protein
Streptomyces sp. NRRL B-24484 309.63 +- 562.34 20 0 5 3 0.06 +- 0.17 20

No common domains found
Streptomyces sp. NRRL F-2580 476.61 +- 1225.46 15 0 5 2 0.09 +- 0.20 15

No common domains found
Streptomyces sp. ICC1 224.15 +- 239.54 27 0 6 2 0.08 +- 0.21 27

No common domains found
Streptomyces atratus 282.15 +- 501.11 24 0 9 2 0.07 +- 0.15 24

No common domains found
Streptomyces sp. NRRL B-1381 174.07 +- 318.42 14 0 5 2 0.12 +- 0.21 14

No common domains found
Streptomyces bicolor 117.61 +- 152.06 32 0 5 2 0.11 +- 0.20 32

No common domains found
Streptomyces globisporus 76.26 +- 62.59 8 0 4 1 0.17 +- 0.26 8

No common domains found
Streptomyces sp. Act143 407.84 +- 1218.04 24 0 4 1 0.10 +- 0.20 24

No common domains found
Streptomyces flavovariabilis 136.08 +- 170.69 16 0 5 1 0.12 +- 0.15 16

No common domains found
Streptomyces atroolivaceus 178.54 +- 200.47 19 0 3 1 0.10 +- 0.16 19

No common domains found
Streptomyces lunaelactis 130.47 +- 109.83 21 0 5 1 0.09 +- 0.18 21

No common domains found
Streptomyces sparsogenes 170.44 +- 210.02 14 0 6 5 0.10 +- 0.23 14

No common domains found
Streptomyces griseus subsp. rhodochrous 96.84 +- 65.12 17 0 7 4 0.11 +- 0.19 17

No common domains found
Streptomyces sp. HG99 147.38 +- 129.98 20 0 3 1 0.08 +- 0.13 20

No common domains found
Streptomyces sp. MA5143a 215.30 +- 247.22 16 0 4 0 0.07 +- 0.13 16

No common domains found
Streptomyces sp. M7 137.92 +- 146.79 15 0 0 0 0.11 +- 0.14 15

No common domains found
Streptomyces sp. F-1 291.20 +- 646.41 24 0 7 4 0.09 +- 0.19 24

No common domains found
Streptomyces viridosporus T7A 233.17 +- 266.17 16 0 4 2 0.08 +- 0.16 16

No common domains found
Streptomyces griseus subsp. rhodochrous 100.69 +- 93.58 15 0 6 5 0.12 +- 0.21 15

No common domains found
Streptomyces cyaneus 407.16 +- 1188.41 31 0 8 1 0.10 +- 0.19 31

No common domains found
Streptomyces sp. NRRL B-3229 75.30 +- 71.18 5 0 1 0 0.07 +- 0.12 5

No common domains found
Candidatus Streptomyces philanthi 540.83 +- 1347.62 15 0 7 5 0.08 +- 0.16 15

No common domains found
Streptomyces sp. W1SF4 373.59 +- 469.04 14 0 8 3 0.08 +- 0.21 14

No common domains found
Streptomyces sp. TRM44457 200.68 +- 173.11 11 0 0 0 0.06 +- 0.18 11

No common domains found
Streptomyces badius 175.52 +- 244.06 17 0 5 2 0.10 +- 0.15 17

No common domains found
Streptomyces ossamyceticus 188.57 +- 269.76 15 0 3 0 0.10 +- 0.18 15

No common domains found
Streptomyces sp. 3212.2 273.72 +- 578.04 29 0 7 1 0.10 +- 0.18 29

No common domains found
Streptomyces bottropensis ATCC 25435 278.71 +- 682.01 19 0 7 3 0.10 +- 0.18 19

No common domains found
Streptomyces sp. NRRL F-6628 345.43 +- 516.44 8 0 3 3 0.07 +- 0.17 8

No common domains found
Streptomyces caatingaensis 327.36 +- 294.03 11 0 7 4 0.08 +- 0.22 11

No common domains found
Streptomyces sp. 4F 187.44 +- 286.08 15 0 4 1 0.09 +- 0.14 15

No common domains found
Streptomyces sp. CEV 2-1 195.95 +- 184.49 19 0 6 2 0.10 +- 0.19 19

No common domains found
Streptomyces olivoreticuli subsp. olivoreticuli 251.20 +- 238.58 31 0 15 5 0.08 +- 0.18 31

No common domains found
Streptomyces olivaceus 188.30 +- 251.87 10 0 5 1 0.14 +- 0.21 10

No common domains found
Streptomyces sp. PAMC 26508 191.59 +- 200.44 14 0 6 2 0.12 +- 0.20 14

No common domains found
Streptomyces sp. FT05W 154.72 +- 256.76 5 0 1 2 0.09 +- 0.11 5

No common domains found
Streptomyces sp. AcH 505 691.37 +- 1015.52 30 0 7 1 0.06 +- 0.17 30

No common domains found
Streptomyces griseolus 180.66 +- 224.99 7 0 0 3 0.04 +- 0.05 7

No common domains found
Streptomyces sp. MUSC 125 206.58 +- 211.38 8 0 4 1 0.10 +- 0.23 8

No common domains found
Streptomyces pharetrae CZA14 413.04 +- 444.71 7 0 3 1 0.08 +- 0.22 7

No common domains found
Streptomyces sp. ScaeMP-6W 390.30 +- 870.69 11 0 3 4 0.08 +- 0.17 11

No common domains found
Streptomyces griseoruber 661.11 +- 774.24 19 0 4 1 0.05 +- 0.13 19

No common domains found
Streptomyces sp. NRRL WC-3540 85.82 +- 58.71 10 0 3 5 0.11 +- 0.18 10

No common domains found
Streptomyces peucetius 197.22 +- 303.52 19 0 5 3 0.08 +- 0.18 19

No common domains found
Streptomyces xanthophaeus 405.44 +- 628.12 16 0 7 3 0.09 +- 0.20 16

No common domains found
Streptomyces scabiei 113.93 +- 99.11 11 0 1 0 0.06 +- 0.08 11

No common domains found
Streptomyces sp. NRRL F-5123 243.85 +- 292.19 19 0 8 2 0.06 +- 0.13 19

No common domains found
Streptomyces violens 279.88 +- 331.47 19 0 9 1 0.11 +- 0.23 19

No common domains found
Streptomyces albulus CCRC 11814 312.68 +- 448.83 22 0 9 2 0.06 +- 0.11 22

No common domains found
Streptomyces violaceoruber 123.26 +- 141.38 7 0 4 1 0.13 +- 0.17 7

No common domains found
Streptomyces sp. CS065A 125.27 +- 156.69 18 0 7 2 0.11 +- 0.19 18

No common domains found
Streptomyces anulatus 90.23 +- 107.85 19 0 6 4 0.15 +- 0.19 19

No common domains found
Streptomyces clavuligerus 266.17 +- 288.48 17 0 9 1 0.05 +- 0.12 17

No common domains found
Streptomyces kebangsaanensis 80.93 +- 52.61 13 0 2 1 0.13 +- 0.24 13

No common domains found
Streptomyces sp. YIM 130001 280.11 +- 489.95 13 0 4 1 0.12 +- 0.25 13

No common domains found
Streptomyces sp. NRRL F-5755 189.00 +- 421.32 17 0 8 2 0.08 +- 0.09 17

No common domains found
Streptomyces chartreusis NRRL 12338 127.33 +- 177.27 12 0 2 2 0.12 +- 0.11 12

No common domains found
Streptomyces sp. NRRL S-104 273.83 +- 263.12 6 0 4 1 0.05 +- 0.13 6 6

TIGR01733 (3/6) amino acid adenylation domain
PF13193 (3/6) AMP-binding enzyme C-terminal domain
PF07690 (3/6) Major Facilitator Superfamily
PF00668 (3/6) Condensation domain
PF00550 (3/6) Phosphopantetheine attachment site
PF00501 (3/6) AMP-binding enzyme
Streptomyces sp. ACT-1 383.93 +- 627.86 23 0 11 6 0.07 +- 0.15 23

No common domains found
Streptomyces sp. DH-12 49.08 +- 19.22 13 0 5 1 0.16 +- 0.24 13

No common domains found
Streptomyces sp. CB02058 104.61 +- 131.82 18 0 7 3 0.10 +- 0.14 18

No common domains found
Streptomyces glaucescens 57.91 +- 44.73 7 0 1 0 0.13 +- 0.24 7

No common domains found
Streptomyces sp. BoleA5 148.57 +- 130.52 18 0 6 1 0.09 +- 0.18 18

No common domains found
Streptomyces sp. XY413 312.78 +- 473.78 16 0 9 2 0.07 +- 0.17 16

No common domains found
Streptomyces sp. VMFN-G11Ma 428.77 +- 1097.28 35 0 6 2 0.10 +- 0.19 35

No common domains found
Streptomyces lydicus 141.80 +- 178.53 11 0 4 2 0.13 +- 0.19 11

No common domains found
Streptomyces sp. CNS335 245.08 +- 274.00 19 0 6 1 0.09 +- 0.18 19

No common domains found
Streptomyces sp. 13-12-16 138.22 +- 125.46 9 0 1 0 0.15 +- 0.18 9

No common domains found
Streptomyces rimosus subsp. rimosus 138.28 +- 282.50 21 0 9 4 0.12 +- 0.18 21

No common domains found
Streptomyces sp. 2231.1 233.39 +- 291.35 13 0 6 3 0.08 +- 0.19 13

No common domains found