RiPP-TIDE results


Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_groups_2167 335.83 +- 270.37 4 0 3 0 0.11 +- 0.20 4 6

PF07969 (2/4) Amidohydrolase family
PF07859 (2/4) alpha/beta hydrolase fold
PF07729 (2/4) FCD domain
PF02126 (2/4) Phosphotriesterase family
PF00561 (2/4) alpha/beta hydrolase fold
PF00392 (2/4) Bacterial regulatory proteins, gntR family

precursor_groups_68013 42.47 +- 9.53 2 0 1 0 0.07 +- 0.05 2 9

TIGR00641 (2/2) methylmalonyl-CoA mutase N-terminal domain
PF14435 (2/2) SUKH-4 immunity protein
PF03308 (2/2) Methylmalonyl Co-A mutase-associated GTPase MeaB
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02310 (2/2) B12 binding domain
PF01642 (2/2) Methylmalonyl-CoA mutase
PF01321 (2/2) Creatinase/Prolidase N-terminal domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00557 (2/2) Metallopeptidase family M24

precursor_groups_40931 893.37 +- 424.28 2 0 2 0 0.01 +- 0.02 2 24

TIGR01733 (2/2) amino acid adenylation domain
TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12802 (2/2) MarR family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01613 (2/2) Flavin reductase like domain
PF01474 (2/2) Class-II DAHP synthetase family
PF00975 (2/2) Thioesterase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_343 103.13 +- 13.39 3 0 0 2 0.12 +- 0.14 3 4

PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
PF02223 (2/3) Thymidylate kinase
PF00293 (2/3) NUDIX domain

precursor_groups_2166 106.97 +- 108.30 3 0 0 0 0.05 +- 0.11 3 6

PF17853 (2/3) GGDEF-like domain
PF14333 (2/3) Domain of unknown function (DUF4389)
PF13556 (2/3) PucR C-terminal helix-turn-helix domain
PF08448 (2/3) PAS fold
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF03492 (2/3) SAM dependent carboxyl methyltransferase

precursor_groups_12041 305.66 +- 186.24 7 0 6 0 0.07 +- 0.21 7 8

TIGR01181 (7/7) dTDP-glucose 4,6-dehydratase
PF17755 (7/7) UvrA DNA-binding domain
PF16363 (7/7) GDP-mannose 4,6 dehydratase
PF13460 (7/7) NAD(P)H-binding
PF05368 (7/7) NmrA-like family
PF03992 (7/7) Antibiotic biosynthesis monooxygenase
PF03559 (7/7) NDP-hexose 2,3-dehydratase
PF00005 (7/7) ABC transporter

precursor_groups_75537 54.17 +- 0.00 2 0 0 0 0.11 +- 0.21 2 6

TIGR01806 (2/2) putative chorismate mutase
PF13808 (2/2) DDE_Tnp_1-associated
PF07730 (2/2) Histidine kinase
PF01817 (2/2) Chorismate mutase type II
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain

precursor_groups_75535 1498.58 +- 93.92 2 0 2 0 0.01 +- 0.00 2 16

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03795 (2/2) YCII-related domain
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF03737 (2/2) Aldolase/RraA
PF03466 (2/2) LysR substrate binding domain
PF03060 (2/2) Nitronate monooxygenase
PF01738 (2/2) Dienelactone hydrolase family
PF00890 (2/2) FAD binding domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00682 (2/2) HMGL-like
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_74008 412.80 +- 103.20 2 0 2 2 0.01 +- 0.00 2 2

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00069 (2/2) Protein kinase domain

precursor_groups_70010 49.83 +- 15.17 2 0 0 0 0.04 +- 0.05 2 8

PF13481 (2/2) AAA domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF10935 (2/2) Protein of unknown function (DUF2637)
PF07508 (2/2) Recombinase
PF05713 (2/2) Bacterial mobilisation protein (MobC)
PF03432 (2/2) Relaxase/Mobilisation nuclease domain
PF00772 (2/2) DnaB-like helicase N terminal domain
PF00239 (2/2) Resolvase, N terminal domain

precursor_groups_18375 96.51 +- 36.71 4 0 0 0 0.15 +- 0.14 4 15

TIGR01392 (4/4) homoserine O-acetyltransferase
TIGR01326 (4/4) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF18029 (4/4) Glyoxalase-like domain
PF08007 (4/4) Cupin superfamily protein
PF06999 (4/4) Sucrase/ferredoxin-like
PF03404 (4/4) Mo-co oxidoreductase dimerisation domain
PF01184 (4/4) GPR1/FUN34/yaaH family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00561 (4/4) alpha/beta hydrolase fold
PF00174 (4/4) Oxidoreductase molybdopterin binding domain
TIGR01409 (3/4) Tat (twin-arginine translocation) pathway signal sequence
TIGR02980 (2/4) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF04545 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04539 (2/4) Sigma-70 region 3

precursor_groups_25857 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family

precursor_groups_61625 148.71 +- 51.96 2 0 0 0 0.05 +- 0.05 2 6

PF14279 (2/2) HNH endonuclease
PF13560 (2/2) Helix-turn-helix domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF07508 (2/2) Recombinase
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF00239 (2/2) Resolvase, N terminal domain

precursor_groups_38466 1034.67 +- 3.77 3 0 0 0 0.01 +- 0.00 3 5

PF14833 (3/3) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF07690 (3/3) Major Facilitator Superfamily
PF03446 (3/3) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2

precursor_groups_78265 112.97 +- 0.00 2 0 2 0 0.19 +- 0.32 2 19

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16864 (2/2) Dimerisation domain
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF04673 (2/2) Polyketide synthesis cyclase
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01039 (2/2) Carboxyl transferase domain
PF00931 (2/2) NB-ARC domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase

precursor_groups_56123 69.55 +- 8.45 2 0 0 0 0.04 +- 0.05 2 3

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF00719 (2/2) Inorganic pyrophosphatase
PF00005 (2/2) ABC transporter

precursor_groups_52139 272.88 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR00212 (2/2) hydroxymethylbilane synthase
PF05977 (2/2) Transmembrane secretion effector
PF01379 (2/2) Porphobilinogen deaminase, dipyromethane cofactor binding domain
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF03900 (1/2) Porphobilinogen deaminase, C-terminal domain

precursor_groups_12911 39.50 +- 3.50 2 0 2 0 0.24 +- 0.16 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01443 (2/2) intein C-terminal splicing region
PF07591 (2/2) Pretoxin HINT domain
PF01804 (2/2) Penicillin amidase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter
PF00501 (1/2) AMP-binding enzyme

precursor_groups_25690 172.67 +- 61.75 3 0 3 0 0.01 +- 0.00 3 3

PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/3) Phosphopantetheine attachment site

precursor_groups_58413 64.48 +- 6.70 2 0 0 0 0.06 +- 0.04 2 3

PF13545 (2/2) Crp-like helix-turn-helix domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00027 (2/2) Cyclic nucleotide-binding domain

precursor_groups_53332 174.34 +- 16.77 2 0 0 0 0.05 +- 0.03 2 7

TIGR00797 (2/2) MATE efflux family protein
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/2) MatE
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00278 (2/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain

precursor_groups_52131 106.50 +- 54.15 2 0 2 0 0.07 +- 0.21 2 10

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF13469 (2/2) Sulfotransferase family
PF12848 (2/2) ABC transporter
PF07883 (2/2) Cupin domain
PF07730 (2/2) Histidine kinase
PF04672 (2/2) S-adenosyl methyltransferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_24984 42.19 +- 25.31 4 0 0 0 0.07 +- 0.04 4 3

PF02386 (4/4) Cation transport protein
PF02254 (4/4) TrkA-N domain
PF02080 (4/4) TrkA-C domain

precursor_groups_59832 20.21 +- 2.07 2 0 0 0 0.15 +- 0.11 2 8

PF18050 (2/2) Cyclophilin-like family
PF13613 (2/2) Helix-turn-helix of DDE superfamily endonuclease
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13359 (2/2) DDE superfamily endonuclease
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_31630 41.63 +- 6.54 4 0 4 0 0.07 +- 0.09 4 5

PF07690 (4/4) Major Facilitator Superfamily
PF00905 (4/4) Penicillin binding protein transpeptidase domain
PF00266 (4/4) Aminotransferase class-V
PF00171 (4/4) Aldehyde dehydrogenase family
PF13472 (2/4) GDSL-like Lipase/Acylhydrolase family

precursor_groups_75436 171.39 +- 0.64 2 0 2 0 0.09 +- 0.25 2 21

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01733 (2/2) amino acid adenylation domain
PF18563 (2/2) TubC N-terminal docking domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12680 (2/2) SnoaL-like domain
PF08659 (2/2) KR domain
PF05199 (2/2) GMC oxidoreductase
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00732 (2/2) GMC oxidoreductase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_12857 518.00 +- 181.02 3 0 3 0 0.01 +- 0.00 3 3

PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF01613 (3/3) Flavin reductase like domain

precursor_groups_17818 129.68 +- 33.50 4 0 0 0 0.12 +- 0.16 4 7

TIGR00996 (4/4) virulence factor Mce family protein
PF13406 (4/4) Transglycosylase SLT domain
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter
PF13577 (3/4) SnoaL-like domain

precursor_groups_60000 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_2368 283.71 +- 432.09 4 0 4 4 0.14 +- 0.23 4 10

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (4/4) Histidine kinase
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR01207 (3/4) glucose-1-phosphate thymidylyltransferase
TIGR01181 (3/4) dTDP-glucose 4,6-dehydratase
PF16363 (3/4) GDP-mannose 4,6 dehydratase
PF00483 (3/4) Nucleotidyl transferase
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain

precursor_groups_1805 33.92 +- 2.07 4 0 0 0 0.18 +- 0.09 4 7

PF13377 (4/4) Periplasmic binding protein-like domain
PF12831 (4/4) FAD dependent oxidoreductase
PF07859 (4/4) alpha/beta hydrolase fold
PF06808 (4/4) Tripartite ATP-independent periplasmic transporter, DctM component
PF05378 (4/4) Hydantoinase/oxoprolinase N-terminal region
PF01968 (4/4) Hydantoinase/oxoprolinase
PF00356 (4/4) Bacterial regulatory proteins, lacI family

precursor_groups_19371 102.99 +- 16.27 4 0 0 0 0.16 +- 0.25 4 9

TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF13229 (3/4) Right handed beta helix region
PF03476 (3/4) MOSC N-terminal beta barrel domain
PF03473 (3/4) MOSC domain

precursor_groups_18719 303.08 +- 251.76 3 0 2 0 0.09 +- 0.20 3 4

PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF14031 (2/3) Putative serine dehydratase domain
PF01168 (2/3) Alanine racemase, N-terminal domain

precursor_groups_44605 280.61 +- 235.39 2 0 0 0 0.11 +- 0.30 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
PF00067 (2/2) Cytochrome P450
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase

precursor_groups_19376 95.66 +- 39.40 5 0 5 5 0.14 +- 0.10 5 12

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (5/5) ABC-2 type transporter
PF00881 (5/5) Nitroreductase family
PF00005 (5/5) ABC transporter
TIGR03605 (3/5) SagB-type dehydrogenase domain
PF03704 (3/5) Bacterial transcriptional activator domain
PF00931 (3/5) NB-ARC domain
PF00486 (3/5) Transcriptional regulatory protein, C terminal

precursor_groups_44607 189.10 +- 128.56 3 0 0 0 0.09 +- 0.22 3 8

PF16884 (3/3) N-terminal domain of oxidoreductase
PF12146 (3/3) Serine aminopeptidase, S33
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold
PF00107 (3/3) Zinc-binding dehydrogenase
PF00106 (3/3) short chain dehydrogenase
TIGR00711 (2/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/3) Major Facilitator Superfamily

precursor_groups_61925 68.00 +- 18.00 2 0 0 0 0.06 +- 0.04 2 6

PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01206 (2/2) Sulfurtransferase TusA
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00581 (2/2) Rhodanese-like domain
PF00266 (2/2) Aminotransferase class-V

precursor_groups_74313 93.75 +- 3.75 2 0 0 0 0.03 +- 0.03 2 4

TIGR01323 (2/2) nitrile hydratase, alpha subunit
PF02979 (2/2) Nitrile hydratase, alpha chain
PF02211 (2/2) Nitrile hydratase beta subunit
PF00106 (2/2) short chain dehydrogenase

precursor_groups_6399 65.80 +- 23.63 11 0 2 0 0.14 +- 0.16 11 9

PF16896 (11/11) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (11/11) Major Facilitator Superfamily
PF03807 (11/11) NADP oxidoreductase coenzyme F420-dependent
PF02733 (11/11) Dak1 domain
PF01261 (11/11) Xylose isomerase-like TIM barrel
PF00121 (11/11) Triosephosphate isomerase
TIGR02133 (10/11) ribose 5-phosphate isomerase
PF02734 (10/11) DAK2 domain
PF02502 (10/11) Ribose/Galactose Isomerase

precursor_groups_3146 8.40 +- 0.17 2 0 0 0 0.24 +- 0.29 2 3

PF05425 (2/2) Copper resistance protein D
PF00082 (2/2) Subtilase family
PF02104 (1/2) SURF1 family

precursor_groups_1801 678.00 +- 483.00 2 0 1 0 0.01 +- 0.00 2 10

TIGR00055 (1/2) di-trans,poly-cis-decaprenylcistransferase
PF10633 (1/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (1/2) Alpha mannosidase middle domain
PF05977 (1/2) Transmembrane secretion effector
PF01255 (1/2) Putative undecaprenyl diphosphate synthase
PF01074 (1/2) Glycosyl hydrolases family 38 N-terminal domain
PF00704 (1/2) Glycosyl hydrolases family 18
PF00494 (1/2) Squalene/phytoene synthase
PF00348 (1/2) Polyprenyl synthetase
PF00005 (1/2) ABC transporter

precursor_groups_4422 148.18 +- 10.58 2 0 0 0 0.03 +- 0.02 2 6

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13545 (2/2) Crp-like helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00027 (2/2) Cyclic nucleotide-binding domain

precursor_groups_71383 46.14 +- 9.40 2 0 0 0 0.18 +- 0.21 2 17

TIGR00476 (2/2) selenide, water dikinase
TIGR00474 (2/2) L-seryl-tRNA(Sec) selenium transferase
PF13247 (2/2) 4Fe-4S dicluster domain
PF12838 (2/2) 4Fe-4S dicluster domain
PF12390 (2/2) Selenocysteine synthase N terminal
PF09107 (2/2) Elongation factor SelB, winged helix
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03916 (2/2) Polysulphide reductase, NrfD
PF03841 (2/2) L-seryl-tRNA selenium transferase
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00384 (2/2) Molybdopterin oxidoreductase
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF00005 (2/2) ABC transporter
TIGR00475 (1/2) selenocysteine-specific translation elongation factor

precursor_groups_52554 38.27 +- 1.42 2 0 0 0 0.05 +- 0.04 2 2

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_42266 316.69 +- 87.47 3 0 0 0 0.04 +- 0.03 3 10

PF15979 (3/3) Glycosyl hydrolase family 115
PF13378 (3/3) Enolase C-terminal domain-like
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01370 (3/3) NAD dependent epimerase/dehydratase family
PF00877 (3/3) NlpC/P60 family
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF17829 (2/3) Gylcosyl hydrolase family 115 C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family

precursor_groups_3 86.54 +- 147.97 130 0 105 0 0.15 +- 0.23 130 11

PF03777 (130/130) ChpA-C
TIGR03025 (89/130) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13692 (89/130) Glycosyl transferases group 1
PF13480 (89/130) Acetyltransferase (GNAT) domain
PF13439 (89/130) Glycosyltransferase Family 4
PF04932 (89/130) O-Antigen ligase
PF03023 (89/130) Lipid II flippase MurJ
PF02397 (89/130) Bacterial sugar transferase
PF01522 (89/130) Polysaccharide deacetylase
PF00534 (89/130) Glycosyl transferases group 1
PF00348 (73/130) Polyprenyl synthetase

precursor_groups_2 94.59 +- 140.31 76 0 15 2 0.12 +- 0.23 76 2

PF04149 (74/76) Domain of unknown function (DUF397)
PF13560 (64/76) Helix-turn-helix domain

precursor_groups_1 377.46 +- 891.35 59 0 9 11 0.09 +- 0.16 59 2

PF04149 (57/59) Domain of unknown function (DUF397)
PF13560 (31/59) Helix-turn-helix domain

precursor_groups_12191 236.78 +- 244.03 6 0 6 0 0.11 +- 0.24 6 24

TIGR01733 (6/6) amino acid adenylation domain
TIGR01686 (6/6) FkbH domain
PF16197 (6/6) Ketoacyl-synthetase C-terminal extension
PF13193 (6/6) AMP-binding enzyme C-terminal domain
PF08541 (6/6) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF05977 (6/6) Transmembrane secretion effector
PF03621 (6/6) MbtH-like protein
PF02801 (6/6) Beta-ketoacyl synthase, C-terminal domain
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (6/6) Periplasmic binding protein
PF01032 (6/6) FecCD transport family
PF00975 (6/6) Thioesterase domain
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (6/6) Condensation domain
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00109 (6/6) Beta-ketoacyl synthase, N-terminal domain
PF00005 (6/6) ABC transporter
PF07690 (5/6) Major Facilitator Superfamily

precursor_groups_12196 48.94 +- 21.31 5 0 0 0 0.18 +- 0.22 5 9

TIGR03718 (5/5) integral membrane protein, TerC family
PF05331 (5/5) Protein of unknown function (DUF742)
PF03741 (5/5) Integral membrane protein TerC family
PF03259 (5/5) Roadblock/LC7 domain
PF03029 (5/5) Conserved hypothetical ATP binding protein
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF18029 (4/5) Glyoxalase-like domain
PF13407 (4/5) Periplasmic binding protein domain
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_43645 25.15 +- 4.56 2 0 0 0 0.11 +- 0.13 2 4

PF09335 (2/2) SNARE associated Golgi protein
PF00248 (2/2) Aldo/keto reductase family
TIGR03395 (1/2) sphingomyelin phosphodiesterase
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family

precursor_groups_5 70.38 +- 92.87 28 0 0 1 0.12 +- 0.22 28 2

PF04149 (27/28) Domain of unknown function (DUF397)
PF13560 (19/28) Helix-turn-helix domain

precursor_groups_4 46.62 +- 63.63 39 0 3 0 0.16 +- 0.24 39 2

PF04149 (38/39) Domain of unknown function (DUF397)
PF13560 (23/39) Helix-turn-helix domain

precursor_groups_30655 328.72 +- 190.80 4 0 0 0 0.02 +- 0.02 4 9

TIGR00167 (4/4) ketose-bisphosphate aldolase
PF17042 (4/4) Nucleotide-binding C-terminal domain
PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (4/4) GntP family permease
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00392 (4/4) Bacterial regulatory proteins, gntR family

precursor_groups_42466 160.63 +- 37.47 2 0 0 0 0.14 +- 0.22 2 20

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF05025 (2/2) RbsD / FucU transport protein family
PF04909 (2/2) Amidohydrolase
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13464 (1/2) Domain of unknown function (DUF4115)
PF00271 (1/2) Helicase conserved C-terminal domain
PF00270 (1/2) DEAD/DEAH box helicase
PF00069 (1/2) Protein kinase domain

precursor_groups_2107 463.50 +- 30.17 2 0 1 0 0.04 +- 0.10 2 20

PF16861 (1/2) Carbamoyltransferase C-terminus
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13546 (1/2) DDE superfamily endonuclease
PF13463 (1/2) Winged helix DNA-binding domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07592 (1/2) Rhodopirellula transposase DDE domain
PF07510 (1/2) Protein of unknown function (DUF1524)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02729 (1/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02543 (1/2) Carbamoyltransferase N-terminus
PF01928 (1/2) CYTH domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01565 (1/2) FAD binding domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00224 (1/2) Pyruvate kinase, barrel domain
PF00185 (1/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (1/2) Beta-lactamase

precursor_groups_82867 304.17 +- 54.17 2 0 0 0 0.03 +- 0.04 2 6

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter

precursor_groups_67605 29.88 +- 1.21 2 0 0 0 0.13 +- 0.16 2 3

TIGR01755 (2/2) NAD(P)H:quinone oxidoreductase, type IV
PF08445 (2/2) FR47-like protein
PF03358 (2/2) NADPH-dependent FMN reductase

precursor_groups_18487 38.20 +- 0.50 2 0 0 0 0.10 +- 0.13 2 7

PF12728 (2/2) Helix-turn-helix domain
PF11750 (2/2) Protein of unknown function (DUF3307)
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF05707 (2/2) Zonular occludens toxin (Zot)
PF00589 (2/2) Phage integrase family
PF10935 (1/2) Protein of unknown function (DUF2637)
PF00293 (1/2) NUDIX domain

precursor_groups_26005 57.59 +- 39.16 2 0 0 0 0.10 +- 0.09 2 3

PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF00067 (2/2) Cytochrome P450

precursor_groups_44722 55.28 +- 3.51 2 0 2 0 0.18 +- 0.16 2 10

PF18029 (2/2) Glyoxalase-like domain
PF18011 (2/2) C-terminal domain found in long catalases
PF13520 (2/2) Amino acid permease
PF13439 (2/2) Glycosyltransferase Family 4
PF06628 (2/2) Catalase-related immune-responsive
PF04101 (2/2) Glycosyltransferase family 28 C-terminal domain
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF00534 (2/2) Glycosyl transferases group 1
PF00199 (2/2) Catalase
PF00005 (2/2) ABC transporter

precursor_groups_8951 72.06 +- 53.82 7 2 0 0 0.14 +- 0.26 5 8

PF11758 (7/7) Aureocin-like type II bacteriocin
PF03372 (5/7) Endonuclease/Exonuclease/phosphatase family
PF02518 (5/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (5/7) D-alanyl-D-alanine carboxypeptidase
PF00672 (5/7) HAMP domain
PF00512 (5/7) His Kinase A (phospho-acceptor) domain
PF00486 (5/7) Transcriptional regulatory protein, C terminal
PF00072 (5/7) Response regulator receiver domain

precursor_groups_8952 182.98 +- 170.99 10 0 0 0 0.08 +- 0.07 10 7

PF08445 (10/10) FR47-like protein
PF00106 (10/10) short chain dehydrogenase
PF13531 (5/10) Bacterial extracellular solute-binding protein
PF08402 (5/10) TOBE domain
PF00694 (5/10) Aconitase C-terminal domain
PF00528 (5/10) Binding-protein-dependent transport system inner membrane component
PF00005 (5/10) ABC transporter

precursor_groups_8958 25.16 +- 8.72 3 0 0 0 0.14 +- 0.19 3 3

PF13649 (3/3) Methyltransferase domain
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (3/3) Major Facilitator Superfamily

precursor_groups_3707 1140.08 +- 802.11 20 2 18 20 0.04 +- 0.11 18 8

TIGR03897 (20/20) type 2 lantibiotic biosynthesis protein LanM
PF13575 (20/20) Domain of unknown function (DUF4135)
PF05147 (20/20) Lanthionine synthetase C-like protein
PF03412 (20/20) Peptidase C39 family
PF00664 (20/20) ABC transporter transmembrane region
PF00005 (20/20) ABC transporter
PF14867 (17/20) Lantibiotic alpha
PF12730 (16/20) ABC-2 family transporter protein

precursor_groups_74170 929.22 +- 318.78 2 0 0 0 0.01 +- 0.03 2 10

PF14307 (2/2) Glycosyltransferase WbsX
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01061 (2/2) ABC-2 type transporter
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_3703 26.07 +- 4.08 2 0 0 0 0.21 +- 0.25 2 21

PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter
TIGR02434 (1/2) precorrin-6A synthase (deacetylating)
TIGR02257 (1/2) cobaltochelatase, CobN subunit
TIGR00715 (1/2) precorrin-6x reductase
TIGR00313 (1/2) cobyric acid synthase CobQ
TIGR00257 (1/2) uncharacterized protein, YigZ family
PF09186 (1/2) Domain of unknown function (DUF1949)
PF07685 (1/2) CobB/CobQ-like glutamine amidotransferase domain
PF07554 (1/2) FIVAR domain
PF04616 (1/2) Glycosyl hydrolases family 43
PF02571 (1/2) Precorrin-6x reductase CbiJ/CobK
PF02514 (1/2) CobN/Magnesium Chelatase
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01205 (1/2) Uncharacterized protein family UPF0029
PF00590 (1/2) Tetrapyrrole (Corrin/Porphyrin) Methylases
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00498 (1/2) FHA domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00069 (1/2) Protein kinase domain

precursor_groups_5662 38.17 +- 3.77 2 0 0 0 0.11 +- 0.09 2 4

PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01645 (2/2) Conserved region in glutamate synthase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_25585 20.57 +- 7.41 2 0 2 0 0.19 +- 0.27 2 10

TIGR02276 (2/2) 40-residue YVTN family beta-propeller repeat
PF17964 (2/2) Bacterial Ig domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
TIGR04215 (1/2) choice-of-anchor A domain
PF17802 (1/2) Prealbumin-like fold domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13499 (1/2) EF-hand domain pair
PF05425 (1/2) Copper resistance protein D
PF01522 (1/2) Polysaccharide deacetylase
PF01471 (1/2) Putative peptidoglycan binding domain

precursor_groups_29975 1134.75 +- 490.59 4 0 0 0 0.01 +- 0.01 4 9

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF04686 (4/4) Streptomyces sporulation and cell division protein, SsgA
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase

precursor_groups_49867 18.91 +- 0.00 2 0 0 0 0.11 +- 0.08 2 3

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07681 (2/2) DoxX

precursor_groups_17584 53.23 +- 35.55 6 0 0 0 0.08 +- 0.17 6 4

PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00067 (6/6) Cytochrome P450

precursor_groups_51079 103.84 +- 33.99 2 0 2 0 0.06 +- 0.13 2 14

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_23980 117.38 +- 3.56 2 0 0 0 0.03 +- 0.02 2 7

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13545 (2/2) Crp-like helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF00723 (2/2) Glycosyl hydrolases family 15
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF00702 (1/2) haloacid dehalogenase-like hydrolase

precursor_groups_67910 62.67 +- 11.94 2 0 0 0 0.10 +- 0.14 2 7

PF13751 (2/2) Transposase DDE domain
PF12704 (2/2) MacB-like periplasmic core domain
PF05598 (2/2) Transposase domain (DUF772)
PF02687 (2/2) FtsX-like permease family
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter

precursor_groups_1851 104.27 +- 48.02 6 0 0 0 0.18 +- 0.31 6 25

TIGR03217 (6/6) 4-hydroxy-2-oxovalerate aldolase
TIGR03216 (6/6) 2-hydroxymuconic semialdehyde dehydrogenase
TIGR03215 (6/6) acetaldehyde dehydrogenase (acetylating)
TIGR03037 (6/6) 3-hydroxyanthranilate 3,4-dioxygenase
TIGR01814 (6/6) kynureninase
PF09290 (6/6) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08309 (6/6) LVIVD repeat
PF07836 (6/6) DmpG-like communication domain
PF06052 (6/6) 3-hydroxyanthranilic acid dioxygenase
PF04909 (6/6) Amidohydrolase
PF01590 (6/6) GAF domain
PF01557 (6/6) Fumarylacetoacetate (FAA) hydrolase family
PF01118 (6/6) Semialdehyde dehydrogenase, NAD binding domain
PF01042 (6/6) Endoribonuclease L-PSP
PF00682 (6/6) HMGL-like
PF00324 (6/6) Amino acid permease
PF00266 (6/6) Aminotransferase class-V
PF00171 (6/6) Aldehyde dehydrogenase family
PF07690 (4/6) Major Facilitator Superfamily
TIGR01728 (3/6) ABC transporter, substrate-binding protein, aliphatic sulfonates family
PF13649 (3/6) Methyltransferase domain
PF13379 (3/6) NMT1-like family
PF01903 (3/6) CbiX
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00005 (3/6) ABC transporter

precursor_groups_1857 254.54 +- 155.57 3 0 0 1 0.03 +- 0.04 3 6

PF13560 (3/3) Helix-turn-helix domain
PF00239 (3/3) Resolvase, N terminal domain
PF14279 (2/3) HNH endonuclease
PF13408 (2/3) Recombinase zinc beta ribbon domain
PF07508 (2/3) Recombinase
PF02796 (2/3) Helix-turn-helix domain of resolvase

precursor_groups_22101 111.82 +- 15.07 2 0 2 0 0.22 +- 0.29 2 7

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF03412 (2/2) Peptidase C39 family
PF01436 (2/2) NHL repeat
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter

precursor_groups_31913 1300.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13474 (2/2) SnoaL-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07729 (2/2) FCD domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_69635 22.49 +- 4.60 2 0 0 0 0.14 +- 0.07 2 5

TIGR02798 (2/2) 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
PF04909 (2/2) Amidohydrolase
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_34434 86.65 +- 5.24 2 0 0 0 0.23 +- 0.31 2 8

TIGR03445 (2/2) N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
PF12698 (2/2) ABC-2 family transporter protein
PF07730 (2/2) Histidine kinase
PF03995 (2/2) Peptidase inhibitor family I36
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_18390 789.47 +- 163.41 5 0 5 5 0.01 +- 0.02 5 9

TIGR04085 (5/5) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (5/5) Iron-sulfur cluster-binding domain
PF08241 (5/5) Methyltransferase domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF01980 (5/5) tRNA-methyltransferase O
PF01494 (5/5) FAD binding domain
PF17920 (4/5) Tetracyclin repressor-like, C-terminal domain
PF00440 (4/5) Bacterial regulatory proteins, tetR family

precursor_groups_22299 11.52 +- 3.85 3 0 0 0 0.19 +- 0.22 3 5

TIGR00537 (3/3) putative methylase
PF09360 (3/3) Iron-binding zinc finger CDGSH type
PF05175 (3/3) Methyltransferase small domain
PF01266 (3/3) FAD dependent oxidoreductase
PF00355 (3/3) Rieske [2Fe-2S] domain

precursor_groups_7469 389.28 +- 405.50 10 0 9 0 0.02 +- 0.01 10 8

PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01733 (9/10) amino acid adenylation domain
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF00501 (9/10) AMP-binding enzyme
PF12697 (8/10) Alpha/beta hydrolase family

precursor_groups_44042 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I

precursor_groups_44736 458.00 +- 289.51 3 0 3 3 0.04 +- 0.09 3 10

TIGR03945 (3/3) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03297 (3/3) phosphonopyruvate decarboxylase
PF14907 (3/3) Uncharacterised nucleotidyltransferase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF12804 (3/3) MobA-like NTP transferase domain
PF04055 (3/3) Radical SAM superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02310 (3/3) B12 binding domain
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme

precursor_groups_63327 1034.00 +- 514.00 2 0 2 0 0.01 +- 0.00 2 11

TIGR01751 (2/2) crotonyl-CoA carboxylase/reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00107 (2/2) Zinc-binding dehydrogenase
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF07730 (1/2) Histidine kinase
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain

precursor_groups_11533 40.16 +- 13.53 5 0 0 0 0.11 +- 0.11 5 5

PF00877 (5/5) NlpC/P60 family
PF07728 (4/5) AAA domain (dynein-related subfamily)
PF07690 (4/5) Major Facilitator Superfamily
PF03771 (4/5) Domain of unknown function (DUF317)
PF00535 (4/5) Glycosyl transferase family 2

precursor_groups_44044 77.75 +- 5.18 2 0 0 0 0.04 +- 0.02 2 3

PF07883 (2/2) Cupin domain
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (2/2) Phosphotransferase enzyme family

precursor_groups_81 56.39 +- 26.42 13 0 3 0 0.15 +- 0.21 13

No common domains found

precursor_groups_83750 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family

precursor_groups_30245 104.39 +- 13.39 2 0 0 0 0.03 +- 0.02 2 7

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_8488 94.89 +- 16.17 10 0 0 0 0.07 +- 0.04 10 10

TIGR03570 (10/10) sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03025 (10/10) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF17836 (10/10) PglD N-terminal domain
PF13313 (10/10) Domain of unknown function (DUF4082)
PF13205 (10/10) Bacterial Ig-like domain
PF02397 (10/10) Bacterial sugar transferase
PF01408 (10/10) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (10/10) NAD dependent epimerase/dehydratase family
PF01041 (10/10) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (9/10) Glycosyl transferase family 2

precursor_groups_71206 323.52 +- 31.02 2 0 2 0 0.02 +- 0.01 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF06013 (2/2) Proteins of 100 residues with WXG
PF00082 (2/2) Subtilase family

precursor_groups_3369 11.89 +- 1.35 2 0 0 0 0.17 +- 0.09 2 2

PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_3562 136.77 +- 60.08 12 0 0 0 0.18 +- 0.29 12 11

TIGR03177 (12/12) Flp pilus assembly protein CpaB
PF16976 (12/12) Flp pilus assembly protein RcpC/CpaB
PF13400 (12/12) Putative Flp pilus-assembly TadE/G-like
PF07811 (12/12) TadE-like protein
PF07730 (12/12) Histidine kinase
PF00691 (12/12) OmpA family
PF00482 (12/12) Type II secretion system (T2SS), protein F
PF00437 (12/12) Type II/IV secretion system protein
PF00196 (12/12) Bacterial regulatory proteins, luxR family
PF00072 (12/12) Response regulator receiver domain
PF13614 (10/12) AAA domain

precursor_groups_22857 255.55 +- 216.00 5 0 0 0 0.03 +- 0.03 5 4

PF04199 (5/5) Putative cyclase
PF02776 (5/5) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF00205 (5/5) Thiamine pyrophosphate enzyme, central domain
PF02775 (4/5) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

precursor_groups_26758 461.93 +- 111.30 3 0 0 0 0.02 +- 0.05 3 10

TIGR01167 (3/3) LPXTG cell wall anchor domain
PF17802 (3/3) Prealbumin-like fold domain
PF16259 (3/3) Domain of unknown function (DUF4913)
PF12307 (3/3) Protein of unknown function (DUF3631)
PF08239 (3/3) Bacterial SH3 domain
PF07690 (3/3) Major Facilitator Superfamily
PF03771 (3/3) Domain of unknown function (DUF317)
PF01638 (3/3) HxlR-like helix-turn-helix
PF01555 (3/3) DNA methylase
PF00746 (2/3) LPXTG cell wall anchor motif

precursor_groups_7602 92.74 +- 70.19 5 0 0 0 0.08 +- 0.16 5 8

PF13244 (5/5) Domain of unknown function (DUF4040)
PF04039 (5/5) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (5/5) Na+/H+ antiporter subunit
PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (5/5) Proton-conducting membrane transporter
PF00106 (5/5) short chain dehydrogenase
PF04066 (4/5) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF01899 (4/5) Na+/H+ ion antiporter subunit

precursor_groups_64986 129.00 +- 0.00 2 0 2 2 0.02 +- 0.01 2 2

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase

precursor_groups_80812 122.07 +- 0.00 2 0 0 0 0.09 +- 0.07 2 8

PF11975 (2/2) Family 4 glycosyl hydrolase C-terminal domain
PF03537 (2/2) Glycoside-hydrolase family GH114
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02056 (2/2) Family 4 glycosyl hydrolase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_43733 153.45 +- 58.75 3 0 0 0 0.02 +- 0.02 3 2

PF04326 (3/3) Putative DNA-binding domain
PF00106 (3/3) short chain dehydrogenase

precursor_groups_12534 521.13 +- 304.47 2 0 0 0 0.03 +- 0.03 2 14

TIGR04364 (1/2) methyltransferase, FxLD system
PF13565 (1/2) Homeodomain-like domain
PF13358 (1/2) DDE superfamily endonuclease
PF13333 (1/2) Integrase core domain
PF12146 (1/2) Serine aminopeptidase, S33
PF07859 (1/2) alpha/beta hydrolase fold
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/2) FAD binding domain
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/2) Integrase core domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00144 (1/2) Beta-lactamase

precursor_groups_27751 69.23 +- 1.72 2 0 0 0 0.16 +- 0.27 2 9

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF04672 (2/2) S-adenosyl methyltransferase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00501 (2/2) AMP-binding enzyme
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (2/2) ABC transporter

precursor_groups_66779 47.14 +- 1.61 2 0 0 0 0.04 +- 0.04 2 10

TIGR03351 (2/2) phosphonatase-like hydrolase
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF07702 (2/2) UTRA domain
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_18023 42.09 +- 3.31 3 0 0 0 0.22 +- 0.13 3 8

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13343 (3/3) Bacterial extracellular solute-binding protein
PF08402 (3/3) TOBE domain
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF07690 (2/3) Major Facilitator Superfamily

precursor_groups_26356 129.33 +- 90.98 3 0 3 0 0.02 +- 0.02 3 2

PF00583 (3/3) Acetyltransferase (GNAT) family
PF00067 (3/3) Cytochrome P450

precursor_groups_82678 199.67 +- 32.53 2 0 0 0 0.02 +- 0.01 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00561 (2/2) alpha/beta hydrolase fold

precursor_groups_59163 846.72 +- 443.28 2 0 0 0 0.02 +- 0.01 2 8

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF07702 (2/2) UTRA domain
PF01565 (2/2) FAD binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter

precursor_groups_15327 51.21 +- 6.05 3 0 0 0 0.08 +- 0.07 3 5

PF13649 (3/3) Methyltransferase domain
PF11706 (3/3) CGNR zinc finger
PF08445 (3/3) FR47-like protein
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07336 (3/3) Putative stress-induced transcription regulator

precursor_groups_4868 262.34 +- 76.06 15 1 2 0 0.01 +- 0.01 14 4

PF03412 (15/15) Peptidase C39 family
PF00664 (15/15) ABC transporter transmembrane region
PF00005 (15/15) ABC transporter
PF00535 (14/15) Glycosyl transferase family 2

precursor_groups_11338 432.00 +- 121.63 3 0 0 3 0.01 +- 0.00 3 3

TIGR00702 (3/3) YcaO-type kinase domain
PF07812 (3/3) TfuA-like protein
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding

precursor_groups_83411 102.01 +- 7.46 2 0 0 0 0.04 +- 0.03 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family

precursor_groups_61726 22.54 +- 1.10 2 0 2 0 0.18 +- 0.24 2 5

TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02525 (2/2) Flavodoxin-like fold
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_36763 52.15 +- 4.37 2 0 0 0 0.08 +- 0.06 2 6

PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain
PF00128 (2/2) Alpha amylase, catalytic domain

precursor_groups_22925 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily

precursor_groups_76933 67.88 +- 28.88 2 0 0 0 0.04 +- 0.03 2 4

TIGR00120 (2/2) glutamate N-acetyltransferase/amino-acid acetyltransferase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01960 (2/2) ArgJ family
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_4264 56.16 +- 13.04 3 0 0 0 0.18 +- 0.34 3 9

PF13458 (3/3) Periplasmic binding protein
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF00501 (3/3) AMP-binding enzyme
PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF13676 (2/3) TIR domain
PF12399 (2/3) Branched-chain amino acid ATP-binding cassette transporter
PF00400 (2/3) WD domain, G-beta repeat
PF00248 (2/3) Aldo/keto reductase family
PF00005 (2/3) ABC transporter

precursor_groups_41322 451.12 +- 125.20 3 0 2 0 0.03 +- 0.03 3 10

PF14742 (3/3) N-terminal domain of (some) glycogen debranching enzymes
PF10282 (3/3) Lactonase, 7-bladed beta-propeller
PF07883 (3/3) Cupin domain
PF07729 (3/3) FCD domain
PF06202 (3/3) Amylo-alpha-1,6-glucosidase
PF03992 (3/3) Antibiotic biosynthesis monooxygenase
PF03600 (3/3) Citrate transporter
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family

precursor_groups_7289 44.11 +- 2.29 7 0 0 0 0.21 +- 0.34 7 10

TIGR03177 (7/7) Flp pilus assembly protein CpaB
PF16976 (7/7) Flp pilus assembly protein RcpC/CpaB
PF13614 (7/7) AAA domain
PF07811 (7/7) TadE-like protein
PF00482 (7/7) Type II secretion system (T2SS), protein F
PF00437 (7/7) Type II/IV secretion system protein
PF00196 (6/7) Bacterial regulatory proteins, luxR family
PF00072 (6/7) Response regulator receiver domain
PF13400 (4/7) Putative Flp pilus-assembly TadE/G-like
PF00691 (4/7) OmpA family

precursor_groups_23434 338.00 +- 182.00 2 0 0 0 0.02 +- 0.06 2 10

PF07291 (2/2) Methylamine utilisation protein MauE
PF00717 (2/2) Peptidase S24-like
PF00005 (2/2) ABC transporter
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10502 (1/2) Signal peptidase, peptidase S26
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (1/2) FAD binding domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00578 (1/2) AhpC/TSA family
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_4468 180.60 +- 77.40 2 0 0 0 0.01 +- 0.01 2 2

PF02547 (2/2) Queuosine biosynthesis protein
PF00106 (2/2) short chain dehydrogenase

precursor_groups_1149 91.06 +- 51.04 3 0 0 0 0.04 +- 0.04 3 5

TIGR03619 (2/3) probable F420-dependent oxidoreductase, Rv2161c family
PF17765 (2/3) MmyB-like transcription regulator ligand binding domain
PF13560 (2/3) Helix-turn-helix domain
PF00296 (2/3) Luciferase-like monooxygenase
PF00106 (2/3) short chain dehydrogenase

precursor_groups_4466 47.20 +- 0.00 2 0 0 0 0.06 +- 0.07 2 7

TIGR00229 (2/2) PAS domain S-box protein
PF14342 (2/2) Domain of unknown function (DUF4396)
PF13426 (2/2) PAS domain
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01590 (2/2) GAF domain
PF00857 (2/2) Isochorismatase family

precursor_groups_1631 90.47 +- 60.82 44 0 0 0 0.06 +- 0.04 44 4

PF13738 (44/44) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (44/44) FMN-dependent dehydrogenase
PF00999 (44/44) Sodium/hydrogen exchanger family
PF00067 (44/44) Cytochrome P450

precursor_groups_40638 190.65 +- 2.85 2 0 2 0 0.05 +- 0.03 2 11

TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF07993 (2/2) Male sterility protein
PF04072 (2/2) Leucine carboxyl methyltransferase
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01979 (2/2) Amidohydrolase family
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01040 (2/2) UbiA prenyltransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase

precursor_groups_15439 102.80 +- 2.15 2 0 0 0 0.04 +- 0.03 2 5

PF16259 (2/2) Domain of unknown function (DUF4913)
PF12696 (2/2) TraM recognition site of TraD and TraG
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF01425 (2/2) Amidase
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_44557 158.00 +- 72.96 3 0 0 0 0.02 +- 0.01 3 2

PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF00293 (3/3) NUDIX domain

precursor_groups_81476 1089.14 +- 716.86 2 0 2 0 0.02 +- 0.02 2 13

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF17874 (2/2) MalT-like TPR region
PF13560 (2/2) Helix-turn-helix domain
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF01619 (2/2) Proline dehydrogenase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00266 (2/2) Aminotransferase class-V
PF00067 (2/2) Cytochrome P450

precursor_groups_21208 95.67 +- 9.64 2 0 0 2 0.05 +- 0.03 2 10

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
TIGR00710 (2/2) drug resistance transporter, Bcr/CflA subfamily
PF13537 (2/2) Glutamine amidotransferase domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF02195 (2/2) ParB-like nuclease domain
PF00733 (2/2) Asparagine synthase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00132 (2/2) Bacterial transferase hexapeptide (six repeats)
PF00067 (2/2) Cytochrome P450

precursor_groups_65430 35.97 +- 0.14 2 0 0 0 0.08 +- 0.04 2 5

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain

precursor_groups_10114 130.83 +- 75.85 4 0 0 0 0.02 +- 0.01 4 2

PF03795 (4/4) YCII-related domain
PF01425 (4/4) Amidase

precursor_groups_69747 172.30 +- 7.18 2 0 0 0 0.05 +- 0.04 2 5

PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04191 (2/2) Phospholipid methyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_15437 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family

precursor_groups_14123 239.74 +- 139.79 3 0 3 3 0.05 +- 0.04 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter

precursor_groups_2366 440.56 +- 238.32 20 0 0 20 0.03 +- 0.05 20 10

PF14833 (20/20) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (20/20) Glutamine amidotransferase domain
PF13480 (20/20) Acetyltransferase (GNAT) domain
PF07690 (20/20) Major Facilitator Superfamily
PF03641 (20/20) Possible lysine decarboxylase
PF03446 (20/20) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (20/20) N-terminal domain of galactosyltransferase
PF01041 (20/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (20/20) Asparagine synthase
PF00300 (20/20) Histidine phosphatase superfamily (branch 1)

precursor_groups_30889 37.34 +- 3.28 4 0 0 0 0.11 +- 0.13 4 3

PF07690 (4/4) Major Facilitator Superfamily
PF02781 (4/4) Glucose-6-phosphate dehydrogenase, C-terminal domain
PF00106 (4/4) short chain dehydrogenase

precursor_groups_9539 26.59 +- 10.34 2 0 0 0 0.23 +- 0.33 2 10

TIGR02094 (2/2) alpha-glucan phosphorylases
PF12852 (2/2) Cupin
PF12833 (2/2) Helix-turn-helix domain
PF11897 (2/2) Protein of unknown function (DUF3417)
PF07730 (2/2) Histidine kinase
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00343 (2/2) Carbohydrate phosphorylase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain

precursor_groups_3967 54.93 +- 11.05 15 0 0 0 0.19 +- 0.15 15 6

PF02838 (15/15) Glycosyl hydrolase family 20, domain 2
PF01547 (15/15) Bacterial extracellular solute-binding protein
PF00728 (15/15) Glycosyl hydrolase family 20, catalytic domain
PF00722 (15/15) Glycosyl hydrolases family 16
PF00528 (15/15) Binding-protein-dependent transport system inner membrane component
PF00942 (14/15) Cellulose binding domain

precursor_groups_27539 12.71 +- 4.49 2 0 0 0 0.18 +- 0.17 2 3

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain

precursor_groups_3962 20.46 +- 5.91 2 0 0 0 0.17 +- 0.37 2 9

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01694 (2/2) methylthioadenosine phosphorylase
TIGR00220 (2/2) large conductance mechanosensitive channel protein
PF09723 (2/2) Zinc ribbon domain
PF07690 (2/2) Major Facilitator Superfamily
PF01741 (2/2) Large-conductance mechanosensitive channel, MscL
PF01048 (2/2) Phosphorylase superfamily
TIGR01740 (1/2) orotidine 5'-phosphate decarboxylase
PF00215 (1/2) Orotidine 5'-phosphate decarboxylase / HUMPS family

precursor_groups_13873 71.55 +- 21.53 4 0 1 0 0.15 +- 0.17 4 8

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (4/4) virulence factor Mce family protein
PF11887 (4/4) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (4/4) Sigma-70, region 4
PF04542 (4/4) Sigma-70 region 2
PF02470 (4/4) MlaD protein
PF02405 (4/4) Permease MlaE
PF00005 (4/4) ABC transporter

precursor_groups_762 57.50 +- 6.05 4 0 0 4 0.11 +- 0.12 4 6

TIGR02050 (4/4) carboxylate-amine ligase, YbdK family
PF13565 (4/4) Homeodomain-like domain
PF04107 (4/4) Glutamate-cysteine ligase family 2(GCS2)
PF02954 (4/4) Bacterial regulatory protein, Fis family
PF01590 (4/4) GAF domain
PF00733 (4/4) Asparagine synthase

precursor_groups_765 128.79 +- 111.40 28 0 27 27 0.10 +- 0.22 28 5

TIGR03975 (28/28) ribosomal peptide maturation radical SAM protein 1
PF07690 (28/28) Major Facilitator Superfamily
PF02310 (28/28) B12 binding domain
PF00326 (28/28) Prolyl oligopeptidase family
PF04055 (27/28) Radical SAM superfamily

precursor_groups_59538 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01120 (2/2) Alpha-L-fucosidase

precursor_groups_36499 127.11 +- 87.55 3 0 3 0 0.05 +- 0.04 3 3

TIGR04538 (3/3) cytochrome P450, cyclodipeptide synthase-associated
PF00857 (3/3) Isochorismatase family
PF00067 (3/3) Cytochrome P450

precursor_groups_67176 378.02 +- 316.59 2 0 0 0 0.09 +- 0.25 2 7

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00857 (2/2) Isochorismatase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00144 (2/2) Beta-lactamase

precursor_groups_45170 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III

precursor_groups_14454 451.50 +- 64.50 2 0 2 1 0.01 +- 0.00 2 8

PF14518 (1/2) Iron-containing redox enzyme
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (1/2) Radical SAM superfamily
PF02353 (1/2) Mycolic acid cyclopropane synthetase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family

precursor_groups_5029 164.28 +- 117.19 6 0 0 0 0.19 +- 0.30 6 11

TIGR03177 (6/6) Flp pilus assembly protein CpaB
PF16976 (6/6) Flp pilus assembly protein RcpC/CpaB
PF07811 (6/6) TadE-like protein
PF00691 (6/6) OmpA family
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
PF13614 (5/6) AAA domain
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF07730 (5/6) Histidine kinase
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain

precursor_groups_40417 351.80 +- 235.05 3 0 3 0 0.07 +- 0.23 3 7

PF18604 (3/3) Pre ATP-grasp domain
PF18105 (3/3) PGM1 C-terminal domain
PF03949 (3/3) Malic enzyme, NAD binding domain
PF00975 (3/3) Thioesterase domain
PF00390 (3/3) Malic enzyme, N-terminal domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter

precursor_groups_5021 36.02 +- 5.75 6 0 6 0 0.20 +- 0.17 6 8

PF11991 (6/6) Tryptophan dimethylallyltransferase
PF05331 (6/6) Protein of unknown function (DUF742)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF02518 (6/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01212 (6/6) Beta-eliminating lyase
PF00664 (5/6) ABC transporter transmembrane region
PF00005 (5/6) ABC transporter

precursor_groups_20297 120.70 +- 72.67 5 0 5 0 0.02 +- 0.01 5 2

PF11575 (5/5) FhuF 2Fe-2S C-terminal domain
PF04616 (5/5) Glycosyl hydrolases family 43

precursor_groups_15057 215.00 +- 71.67 2 0 2 0 0.02 +- 0.02 2 6

TIGR03105 (2/2) glutamine synthetase, type III
PF13522 (2/2) Glutamine amidotransferase domain
PF01645 (2/2) Conserved region in glutamate synthase
PF01493 (2/2) GXGXG motif
PF01266 (2/2) FAD dependent oxidoreductase
PF00120 (2/2) Glutamine synthetase, catalytic domain

precursor_groups_9995 97.26 +- 83.02 8 0 0 0 0.12 +- 0.27 8 6

TIGR03086 (8/8) TIGR03086 family protein
PF14534 (8/8) Domain of unknown function (DUF4440)
PF11716 (8/8) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08002 (8/8) Protein of unknown function (DUF1697)
PF02983 (8/8) Alpha-lytic protease prodomain
PF00089 (8/8) Trypsin

precursor_groups_15051 94.51 +- 57.36 6 0 0 0 0.03 +- 0.02 6 1

PF01833 (6/6) IPT/TIG domain

precursor_groups_37702 54.17 +- 15.06 3 0 0 0 0.17 +- 0.28 3 12

TIGR01581 (3/3) NifC-like ABC-type porter
TIGR00638 (3/3) molybdenum-pterin binding domain
PF12770 (3/3) CHAT domain
PF12728 (3/3) Helix-turn-helix domain
PF10590 (3/3) Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
PF03459 (3/3) TOBE domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01494 (3/3) FAD binding domain
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter

precursor_groups_46601 61.37 +- 13.71 2 0 0 0 0.17 +- 0.33 2 13

TIGR02246 (2/2) conserved hypothetical protein
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF14534 (2/2) Domain of unknown function (DUF4440)
PF14478 (2/2) Domain of unknown function (DUF4430)
PF13649 (2/2) Methyltransferase domain
PF12822 (2/2) ECF transporter, substrate-specific component
PF04314 (2/2) Copper chaperone PCu(A)C
PF02361 (2/2) Cobalt transport protein
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter

precursor_groups_9446 96.30 +- 21.23 9 0 9 0 0.13 +- 0.10 9 11

TIGR03860 (9/9) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (9/9) FMN reductase
TIGR00738 (9/9) Rrf2 family protein
PF13743 (9/9) Thioredoxin
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF03358 (9/9) NADPH-dependent FMN reductase
PF02082 (9/9) Transcriptional regulator
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (9/9) Luciferase-like monooxygenase
PF00005 (9/9) ABC transporter

precursor_groups_51372 530.00 +- 10.00 2 0 0 0 0.01 +- 0.01 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain

precursor_groups_46973 207.00 +- 16.07 3 0 0 0 0.05 +- 0.07 3 16

PF11308 (3/3) Glycosyl hydrolases related to GH101 family, GH129
PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF04185 (3/3) Phosphoesterase family
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00501 (3/3) AMP-binding enzyme
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00171 (3/3) Aldehyde dehydrogenase family
PF00072 (3/3) Response regulator receiver domain
PF00067 (3/3) Cytochrome P450

precursor_groups_84428 1264.47 +- 1057.53 2 0 1 0 0.01 +- 0.01 2 20

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF00290 (2/2) Tryptophan synthase alpha chain
TIGR03438 (1/2) dimethylhistidine N-methyltransferase
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18555 (1/2) MobL relaxases
PF18013 (1/2) Phage tail lysozyme
PF14528 (1/2) LAGLIDADG-like domain
PF12846 (1/2) AAA-like domain
PF12696 (1/2) TraM recognition site of TraD and TraG
PF12642 (1/2) Conjugative transposon protein TcpC
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF07724 (1/2) AAA domain (Cdc48 subfamily)
PF02534 (1/2) Type IV secretory system Conjugative DNA transfer
PF00562 (1/2) RNA polymerase Rpb2, domain 6
PF00216 (1/2) Bacterial DNA-binding protein
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_21905 285.47 +- 50.52 5 0 0 0 0.02 +- 0.03 5 9

TIGR01324 (5/5) cystathionine beta-lyase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF02786 (5/5) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01053 (5/5) Cys/Met metabolism PLP-dependent enzyme
PF00581 (5/5) Rhodanese-like domain
PF13229 (3/5) Right handed beta helix region
PF02655 (3/5) ATP-grasp domain

precursor_groups_21903 67.32 +- 32.20 5 0 0 0 0.07 +- 0.06 5 8

PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12833 (5/5) Helix-turn-helix domain
PF06719 (5/5) AraC-type transcriptional regulator N-terminus
PF02771 (5/5) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/5) Acyl-CoA dehydrogenase, middle domain
PF00501 (5/5) AMP-binding enzyme
PF00441 (5/5) Acyl-CoA dehydrogenase, C-terminal domain
PF00171 (5/5) Aldehyde dehydrogenase family

precursor_groups_11780 32.68 +- 0.44 3 0 0 0 0.12 +- 0.14 3 4

PF13701 (3/3) Transposase DDE domain group 1
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01476 (3/3) LysM domain
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_83305 377.27 +- 142.73 2 0 0 0 0.01 +- 0.01 2 6

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16990 (2/2) Carbohydrate binding module (family 35)
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03595 (2/2) Voltage-dependent anion channel
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01055 (2/2) Glycosyl hydrolases family 31

precursor_groups_7848 117.23 +- 36.01 6 0 1 0 0.12 +- 0.26 6 14

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF04075 (6/6) F420H(2)-dependent quinone reductase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF01047 (6/6) MarR family
PF00999 (6/6) Sodium/hydrogen exchanger family
PF01613 (5/6) Flavin reductase like domain
PF01494 (5/6) FAD binding domain
PF00289 (4/6) Biotin carboxylase, N-terminal domain
PF02786 (3/6) Carbamoyl-phosphate synthase L chain, ATP binding domain

precursor_groups_788 99.55 +- 52.81 5 0 4 0 0.12 +- 0.19 5 10

TIGR03885 (4/5) probable non-F420 flavinoid oxidoreductase
PF18306 (4/5) SLOG cluster4 family
PF16657 (4/5) Maltogenic Amylase, C-terminal domain
PF07690 (4/5) Major Facilitator Superfamily
PF03641 (4/5) Possible lysine decarboxylase
PF03067 (4/5) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (4/5) Polysaccharide deacetylase
PF00553 (4/5) Cellulose binding domain
PF00296 (4/5) Luciferase-like monooxygenase
PF00128 (4/5) Alpha amylase, catalytic domain

precursor_groups_62077 84.67 +- 18.80 2 0 1 0 0.15 +- 0.16 2 14

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF10518 (2/2) TAT (twin-arginine translocation) pathway signal sequence
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_59685 123.80 +- 33.22 2 0 2 2 0.17 +- 0.09 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_37944 36.01 +- 5.05 2 0 2 0 0.11 +- 0.13 2 4

PF00942 (2/2) Cellulose binding domain
PF00728 (2/2) Glycosyl hydrolase family 20, catalytic domain
PF00722 (2/2) Glycosyl hydrolases family 16
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_80785 630.67 +- 401.33 2 0 2 0 0.02 +- 0.01 2 5

PF08241 (2/2) Methyltransferase domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF03795 (2/2) YCII-related domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF00668 (2/2) Condensation domain

precursor_groups_1450 370.18 +- 456.55 10 0 10 9 0.09 +- 0.25 10 6

PF00069 (10/10) Protein kinase domain
PF00005 (10/10) ABC transporter
PF06114 (9/10) IrrE N-terminal-like domain
PF05147 (9/10) Lanthionine synthetase C-like protein
PF02687 (9/10) FtsX-like permease family
PF00082 (9/10) Subtilase family

precursor_groups_4649 19.36 +- 2.27 5 0 5 0 0.16 +- 0.14 5 6

PF03450 (5/5) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (5/5) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (5/5) [2Fe-2S] binding domain
PF01315 (5/5) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (5/5) FAD binding domain in molybdopterin dehydrogenase
PF00111 (5/5) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_6719 30.61 +- 17.80 10 0 0 0 0.15 +- 0.22 10 5

PF14016 (10/10) Protein of unknown function (DUF4232)
PF03473 (10/10) MOSC domain
PF01636 (10/10) Phosphotransferase enzyme family
PF13560 (9/10) Helix-turn-helix domain
PF04149 (7/10) Domain of unknown function (DUF397)

precursor_groups_5737 240.22 +- 174.68 2 0 0 0 0.09 +- 0.07 2 13

TIGR03211 (2/2) catechol 2,3 dioxygenase
PF07729 (2/2) FCD domain
PF04303 (2/2) PrpF protein
PF03737 (2/2) Aldolase/RraA
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01047 (2/2) MarR family
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13672 (1/2) Protein phosphatase 2C
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF00400 (1/2) WD domain, G-beta repeat

precursor_groups_35846 361.61 +- 108.54 3 0 0 0 0.02 +- 0.01 3 8

TIGR03889 (3/3) nitrile hydratase accessory protein
TIGR03888 (3/3) nitrile hydratase, beta subunit
TIGR01323 (3/3) nitrile hydratase, alpha subunit
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF06496 (3/3) Protein of unknown function (DUF1097)
PF03824 (3/3) High-affinity nickel-transport protein
PF02979 (3/3) Nitrile hydratase, alpha chain
PF02211 (3/3) Nitrile hydratase beta subunit

precursor_groups_45774 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain

precursor_groups_2423 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 5

PF12261 (2/2) Thermostable hemolysin
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III

precursor_groups_23858 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain

precursor_groups_2424 192.76 +- 130.38 3 0 2 0 0.09 +- 0.20 3

No common domains found

precursor_groups_84821 34.25 +- 15.69 2 0 0 0 0.15 +- 0.31 2 10

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF02872 (2/2) 5'-nucleotidase, C-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00149 (2/2) Calcineurin-like phosphoesterase
TIGR00838 (1/2) argininosuccinate lyase
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF04343 (1/2) Protein of unknown function, DUF488
PF00206 (1/2) Lyase

precursor_groups_64153 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter

precursor_groups_84823 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_5280 323.50 +- 63.50 2 0 0 0 0.01 +- 0.00 2 4

PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III
TIGR00674 (1/2) 4-hydroxy-tetrahydrodipicolinate synthase
PF00701 (1/2) Dihydrodipicolinate synthetase family

precursor_groups_5287 9.28 +- 0.62 4 0 0 0 0.22 +- 0.16 4 3

PF13649 (4/4) Methyltransferase domain
PF07883 (4/4) Cupin domain
PF01381 (4/4) Helix-turn-helix

precursor_groups_38063 21.09 +- 7.73 2 0 0 0 0.17 +- 0.27 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13520 (2/2) Amino acid permease
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF06386 (2/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/2) Gas vesicle synthesis protein GvpO
PF05121 (2/2) Gas vesicle protein K
PF05120 (2/2) Gas vesicle protein G
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01590 (2/2) GAF domain
PF00989 (2/2) PAS fold
PF00741 (2/2) Gas vesicle protein
PF00083 (2/2) Sugar (and other) transporter
PF00005 (2/2) ABC transporter

precursor_groups_70686 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_49010 118.08 +- 8.88 2 0 0 0 0.18 +- 0.32 2 14

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF17853 (2/2) GGDEF-like domain
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF04188 (1/2) Mannosyltransferase (PIG-V)

precursor_groups_46772 133.23 +- 124.77 2 0 0 0 0.12 +- 0.16 2 6

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF07488 (2/2) Glycosyl hydrolase family 67 middle domain
PF07477 (2/2) Glycosyl hydrolase family 67 C-terminus
PF00754 (2/2) F5/8 type C domain

precursor_groups_37010 27.93 +- 1.01 2 0 0 0 0.22 +- 0.23 2 5

PF13641 (2/2) Glycosyltransferase like family 2
PF03466 (2/2) LysR substrate binding domain
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_50158 87.43 +- 14.81 2 0 0 0 0.11 +- 0.12 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family
PF00069 (2/2) Protein kinase domain

precursor_groups_9663 191.78 +- 19.93 3 0 0 0 0.13 +- 0.24 3 14

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR00223 (3/3) aspartate 1-decarboxylase
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13378 (3/3) Enolase C-terminal domain-like
PF04542 (3/3) Sigma-70 region 2
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02261 (3/3) Aspartate decarboxylase
PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00150 (3/3) Cellulase (glycosyl hydrolase family 5)
PF14498 (2/3) Glycosyl hydrolase family 65, N-terminal domain

precursor_groups_367 60.63 +- 52.03 2 0 0 0 0.08 +- 0.17 2 18

TIGR00476 (1/2) selenide, water dikinase
TIGR00475 (1/2) selenocysteine-specific translation elongation factor
TIGR00474 (1/2) L-seryl-tRNA(Sec) selenium transferase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF12974 (1/2) ABC transporter, phosphonate, periplasmic substrate-binding protein
PF12390 (1/2) Selenocysteine synthase N terminal
PF09107 (1/2) Elongation factor SelB, winged helix
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03841 (1/2) L-seryl-tRNA selenium transferase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00009 (1/2) Elongation factor Tu GTP binding domain

precursor_groups_360 270.80 +- 445.17 5 0 1 0 0.10 +- 0.25 5

No common domains found

precursor_groups_9667 34.70 +- 1.94 2 0 0 0 0.13 +- 0.14 2 8

PF07730 (2/2) Histidine kinase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00877 (2/2) NlpC/P60 family
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF17829 (1/2) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (1/2) Glycosyl hydrolase family 115

precursor_groups_83236 454.06 +- 20.72 2 0 2 0 0.02 +- 0.02 2 6

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_28755 53.34 +- 5.07 4 0 0 0 0.21 +- 0.18 4 10

TIGR02429 (4/4) 3-oxoacid CoA-transferase, A subunit
TIGR02428 (4/4) 3-oxoacid CoA-transferase, B subunit
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF07883 (4/4) Cupin domain
PF04909 (4/4) Amidohydrolase
PF04199 (4/4) Putative cyclase
PF01557 (4/4) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (4/4) FAD binding domain
PF01144 (4/4) Coenzyme A transferase
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_28754 117.18 +- 80.32 4 0 0 0 0.11 +- 0.21 4 11

PF12833 (4/4) Helix-turn-helix domain
PF02774 (4/4) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (4/4) DJ-1/PfpI family
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00171 (4/4) Aldehyde dehydrogenase family
PF00696 (3/4) Amino acid kinase family
TIGR01296 (2/4) aspartate-semialdehyde dehydrogenase
PF14742 (2/4) N-terminal domain of (some) glycogen debranching enzymes
PF13830 (2/4) Domain of unknown function (DUF4192)

precursor_groups_17383 800.39 +- 557.23 3 0 0 0 0.03 +- 0.12 3 13

TIGR01122 (3/3) branched-chain amino acid aminotransferase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF11583 (3/3) P-aminobenzoate N-oxygenase AurF
PF07690 (3/3) Major Facilitator Superfamily
PF04339 (3/3) Peptidogalycan biosysnthesis/recognition
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02615 (3/3) Malate/L-lactate dehydrogenase
PF02222 (3/3) ATP-grasp domain
PF01063 (3/3) Amino-transferase class IV
PF01070 (2/3) FMN-dependent dehydrogenase

precursor_groups_4482 147.48 +- 74.59 17 0 1 0 0.02 +- 0.01 17 2

PF08241 (17/17) Methyltransferase domain
PF00067 (17/17) Cytochrome P450

precursor_groups_168 91.23 +- 44.86 3 0 0 0 0.11 +- 0.12 3

No common domains found

precursor_groups_47954 35.33 +- 9.33 2 0 2 0 0.09 +- 0.03 2 13

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF00155 (1/2) Aminotransferase class I and II

precursor_groups_165 137.00 +- 192.16 11 0 2 0 0.05 +- 0.04 11 4

PF17074 (8/11) Darcynin, domain of unknown function
PF08021 (8/11) Siderophore-interacting FAD-binding domain
PF04954 (8/11) Siderophore-interacting protein
PF03446 (8/11) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_47950 185.98 +- 50.28 3 0 0 0 0.09 +- 0.07 3 9

PF17851 (3/3) Beta xylosidase C-terminal Concanavalin A-like domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF12902 (3/3) Ferritin-like
PF04616 (3/3) Glycosyl hydrolases family 43
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_69336 2680.76 +- 157.24 2 0 2 0 0.01 +- 0.00 2 16

PF14535 (2/2) AMP-binding enzyme C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF10067 (2/2) Predicted membrane protein (DUF2306)
PF08031 (2/2) Berberine and berberine like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03301 (2/2) Tryptophan 2,3-dioxygenase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01757 (2/2) Acyltransferase family
PF01565 (2/2) FAD binding domain
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00144 (2/2) Beta-lactamase

precursor_groups_160 58.91 +- 34.91 2 0 0 0 0.07 +- 0.04 2 6

PF13602 (2/2) Zinc-binding dehydrogenase
PF08241 (2/2) Methyltransferase domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
TIGR01552 (1/2) prevent-host-death family protein
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF02604 (1/2) Antitoxin Phd_YefM, type II toxin-antitoxin system

precursor_groups_5606 71.62 +- 28.48 4 0 1 0 0.06 +- 0.06 4 8

PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00553 (4/4) Cellulose binding domain
TIGR01180 (3/4) putative alpha-1,2-mannosidase
PF17678 (3/4) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/4) Glycosyl hydrolase family 92
PF02518 (3/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/4) HAMP domain
PF00512 (3/4) His Kinase A (phospho-acceptor) domain

precursor_groups_10801 656.39 +- 462.45 5 0 5 0 0.07 +- 0.20 5 5

PF13649 (5/5) Methyltransferase domain
PF12697 (5/5) Alpha/beta hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
PF01593 (3/5) Flavin containing amine oxidoreductase

precursor_groups_2887 1560.00 +- 260.00 2 0 2 0 0.01 +- 0.00 2 17

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01261 (2/2) Xylose isomerase-like TIM barrel
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF12697 (1/2) Alpha/beta hydrolase family
PF07702 (1/2) UTRA domain
PF07690 (1/2) Major Facilitator Superfamily
PF06283 (1/2) Trehalose utilisation
PF01761 (1/2) 3-dehydroquinate synthase
PF01757 (1/2) Acyltransferase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00905 (1/2) Penicillin binding protein transpeptidase domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase

precursor_groups_63615 13.01 +- 2.18 2 0 0 0 0.19 +- 0.06 2 3

PF00704 (2/2) Glycosyl hydrolases family 18
PF00082 (2/2) Subtilase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain

precursor_groups_4424 12.41 +- 4.04 4 0 0 0 0.20 +- 0.20 4 6

PF10282 (4/4) Lactonase, 7-bladed beta-propeller
PF07702 (4/4) UTRA domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
TIGR03173 (2/4) xanthine permease
PF00860 (2/4) Permease family
PF00561 (2/4) alpha/beta hydrolase fold

precursor_groups_35939 255.53 +- 31.14 2 0 0 0 0.05 +- 0.11 2 9

PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF08125 (2/2) Mannitol dehydrogenase C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01232 (2/2) Mannitol dehydrogenase Rossmann domain
PF01022 (1/2) Bacterial regulatory protein, arsR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family

precursor_groups_80255 166.53 +- 14.34 2 0 2 0 0.07 +- 0.15 2 10

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13185 (2/2) GAF domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF03861 (2/2) ANTAR domain
PF01979 (2/2) Amidohydrolase family
PF01494 (2/2) FAD binding domain
PF00571 (2/2) CBS domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_2398 891.76 +- 855.62 6 0 6 0 0.04 +- 0.14 6 5

PF13649 (6/6) Methyltransferase domain
PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF12697 (6/6) Alpha/beta hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter

precursor_groups_84222 159.00 +- 17.98 2 0 0 0 0.11 +- 0.16 2 21

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
PF13607 (2/2) Succinyl-CoA ligase like flavodoxin domain
PF13380 (2/2) CoA binding domain
PF09084 (2/2) NMT1/THI5 like
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF04016 (2/2) Putative heavy-metal chelation
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13549 (1/2) ATP-grasp domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00285 (1/2) Citrate synthase, C-terminal domain

precursor_groups_13295 17.22 +- 5.22 2 0 0 0 0.13 +- 0.12 2 6

PF13600 (2/2) N-terminal domain of unknown function (DUF4140)
PF13598 (2/2) Domain of unknown function (DUF4139)
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00037 (2/2) 4Fe-4S binding domain
TIGR02231 (1/2) conserved hypothetical protein

precursor_groups_30538 20.18 +- 2.70 3 0 0 0 0.20 +- 0.15 3 10

TIGR01660 (3/3) nitrate reductase, beta subunit
TIGR01580 (3/3) nitrate reductase, alpha subunit
TIGR00684 (3/3) nitrate reductase molybdenum cofactor assembly chaperone
TIGR00351 (3/3) respiratory nitrate reductase, gamma subunit
PF14711 (3/3) Respiratory nitrate reductase beta C-terminal
PF13247 (3/3) 4Fe-4S dicluster domain
PF02665 (3/3) Nitrate reductase gamma subunit
PF02613 (3/3) Nitrate reductase delta subunit
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase

precursor_groups_181 475.68 +- 315.80 7 0 1 0 0.05 +- 0.13 7

No common domains found

precursor_groups_183 131.58 +- 94.35 9 0 8 0 0.03 +- 0.01 9 4

TIGR01509 (8/9) HAD hydrolase, family IA, variant 3
PF03756 (8/9) A-factor biosynthesis hotdog domain
PF00702 (8/9) haloacid dehalogenase-like hydrolase
PF00067 (8/9) Cytochrome P450

precursor_groups_32620 831.24 +- 728.76 2 0 2 2 0.06 +- 0.23 2 8

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF01061 (2/2) ABC-2 type transporter
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00160 (2/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00005 (2/2) ABC transporter

precursor_groups_2393 47.72 +- 21.39 2 0 1 0 0.18 +- 0.15 2 12

PF00005 (2/2) ABC transporter
PF18368 (1/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF17786 (1/2) Mannosidase Ig/CBM-like domain
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF11706 (1/2) CGNR zinc finger
PF07336 (1/2) Putative stress-induced transcription regulator
PF02225 (1/2) PA domain
PF00754 (1/2) F5/8 type C domain
PF00703 (1/2) Glycosyl hydrolases family 2
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family

precursor_groups_39634 47.33 +- 29.24 2 0 0 0 0.18 +- 0.13 2 14

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13412 (2/2) Winged helix-turn-helix DNA-binding
PF04030 (2/2) D-arabinono-1,4-lactone oxidase
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01565 (2/2) FAD binding domain
PF00480 (2/2) ROK family
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07690 (1/2) Major Facilitator Superfamily
PF06182 (1/2) ABC-2 family transporter protein
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter

precursor_groups_2396 896.34 +- 972.37 4 0 0 2 0.02 +- 0.03 4

No common domains found

precursor_groups_59574 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_46807 17.20 +- 4.91 2 0 2 0 0.12 +- 0.06 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_41270 25.24 +- 0.00 2 0 0 0 0.16 +- 0.10 2 5

TIGR00791 (2/2) transporter, gluconate:H+ symporter (GntP) family
PF13378 (2/2) Enolase C-terminal domain-like
PF02447 (2/2) GntP family permease
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_7188 136.13 +- 130.67 7 0 0 0 0.16 +- 0.21 7 7

PF07705 (6/7) CARDB
PF01547 (6/7) Bacterial extracellular solute-binding protein
PF00754 (6/7) F5/8 type C domain
PF00528 (6/7) Binding-protein-dependent transport system inner membrane component
PF00128 (6/7) Alpha amylase, catalytic domain
PF11941 (5/7) Domain of unknown function (DUF3459)
PF00583 (4/7) Acetyltransferase (GNAT) family

precursor_groups_9061 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_500 91.46 +- 272.54 22 0 1 1 0.17 +- 0.25 22 4

PF01145 (18/22) SPFH domain / Band 7 family
PF03067 (17/22) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF00501 (13/22) AMP-binding enzyme
PF13193 (12/22) AMP-binding enzyme C-terminal domain

precursor_groups_504 311.04 +- 329.44 3 0 1 0 0.07 +- 0.13 3 10

PF13545 (2/3) Crp-like helix-turn-helix domain
PF13191 (2/3) AAA ATPase domain
PF07366 (2/3) SnoaL-like polyketide cyclase
PF03176 (2/3) MMPL family
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00899 (2/3) ThiF family
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00211 (2/3) Adenylate and Guanylate cyclase catalytic domain
PF00027 (2/3) Cyclic nucleotide-binding domain

precursor_groups_29576 207.33 +- 73.07 3 0 0 0 0.01 +- 0.01 3 2

PF07859 (3/3) alpha/beta hydrolase fold
PF01569 (3/3) PAP2 superfamily

precursor_groups_71640 551.25 +- 228.75 2 0 0 0 0.03 +- 0.07 2 15

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13701 (2/2) Transposase DDE domain group 1
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF10605 (2/2) 3HB-oligomer hydrolase (3HBOH)
PF10503 (2/2) Esterase PHB depolymerase
PF07519 (2/2) Tannase and feruloyl esterase
PF04444 (2/2) Catechol dioxygenase N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00501 (2/2) AMP-binding enzyme
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00041 (2/2) Fibronectin type III domain

precursor_groups_17102 5432.92 +- 2546.80 4 0 4 4 0.02 +- 0.10 4 10

PF13732 (4/4) Domain of unknown function (DUF4162)
PF13649 (4/4) Methyltransferase domain
PF12698 (4/4) ABC-2 family transporter protein
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein

precursor_groups_59779 511.00 +- 91.00 2 0 0 0 0.01 +- 0.01 2 8

TIGR01722 (2/2) methylmalonate-semialdehyde dehydrogenase (acylating)
PF11534 (2/2) Hexameric tyrosine-coordinated heme protein (HTHP)
PF07690 (2/2) Major Facilitator Superfamily
PF03404 (2/2) Mo-co oxidoreductase dimerisation domain
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00155 (2/2) Aminotransferase class I and II

precursor_groups_2991 114.78 +- 35.75 6 0 0 5 0.23 +- 0.08 6 34

TIGR03026 (6/6) nucleotide sugar dehydrogenase
PF13857 (6/6) Ankyrin repeats (many copies)
PF13692 (6/6) Glycosyl transferases group 1
PF13579 (6/6) Glycosyl transferase 4-like domain
PF06628 (6/6) Catalase-related immune-responsive
PF03721 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02706 (6/6) Chain length determinant protein
PF00984 (6/6) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00199 (6/6) Catalase
TIGR01536 (5/6) asparagine synthase (glutamine-hydrolyzing)
PF16889 (5/6) Heparinase II/III N-terminus
PF16254 (5/6) Domain of unknown function (DUF4910)
PF16221 (5/6) winged helix-turn-helix
PF13537 (5/6) Glutamine amidotransferase domain
PF13489 (5/6) Methyltransferase domain
PF13439 (5/6) Glycosyltransferase Family 4
PF08484 (5/6) C-methyltransferase C-terminal domain
PF08421 (5/6) Putative zinc binding domain
PF07940 (5/6) Heparinase II/III-like protein
PF04230 (5/6) Polysaccharide pyruvyl transferase
PF02585 (5/6) GlcNAc-PI de-N-acetylase
PF01408 (5/6) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (5/6) NAD dependent epimerase/dehydratase family
PF00908 (5/6) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00733 (5/6) Asparagine synthase
PF00535 (5/6) Glycosyl transferase family 2
PF00534 (5/6) Glycosyl transferases group 1
PF00202 (5/6) Aminotransferase class-III
PF00107 (5/6) Zinc-binding dehydrogenase
PF13229 (4/6) Right handed beta helix region
TIGR03025 (3/6) exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
PF13727 (3/6) CoA-binding domain
PF02397 (3/6) Bacterial sugar transferase

precursor_groups_2774 281.60 +- 201.42 3 0 2 0 0.05 +- 0.07 3 1

PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain

precursor_groups_3410 191.33 +- 9.33 2 0 0 0 0.01 +- 0.01 2 3

PF13560 (2/2) Helix-turn-helix domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

precursor_groups_2086 93.31 +- 21.31 29 0 0 0 0.14 +- 0.25 29 11

TIGR00229 (29/29) PAS domain S-box protein
PF08795 (29/29) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (29/29) Animal haem peroxidase
PF02585 (29/29) GlcNAc-PI de-N-acetylase
PF01061 (29/29) ABC-2 type transporter
PF00989 (29/29) PAS fold
PF00933 (29/29) Glycosyl hydrolase family 3 N terminal domain
PF00582 (29/29) Universal stress protein family
PF00199 (29/29) Catalase
PF00196 (29/29) Bacterial regulatory proteins, luxR family
PF00005 (29/29) ABC transporter

precursor_groups_47605 632.96 +- 689.98 3 0 0 0 0.09 +- 0.20 3 9

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF05345 (3/3) Putative Ig domain
PF04978 (3/3) Protein of unknown function (DUF664)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01483 (3/3) Proprotein convertase P-domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00664 (3/3) ABC transporter transmembrane region
PF00656 (3/3) Caspase domain
PF00005 (3/3) ABC transporter

precursor_groups_55169 228.36 +- 13.36 2 0 2 0 0.17 +- 0.30 2 24

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13577 (2/2) SnoaL-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07366 (2/2) SnoaL-like polyketide cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF18369 (1/2) Polyketide synthase dimerisation element domain
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13602 (1/2) Zinc-binding dehydrogenase
PF13191 (1/2) AAA ATPase domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family

precursor_groups_2083 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_987 50.17 +- 2.49 3 0 0 0 0.16 +- 0.33 3 7

TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR01550 (3/3) death-on-curing family protein
PF07690 (3/3) Major Facilitator Superfamily
PF05362 (3/3) Lon protease (S16) C-terminal proteolytic domain
PF02661 (3/3) Fic/DOC family
PF00082 (3/3) Subtilase family
PF04851 (2/3) Type III restriction enzyme, res subunit

precursor_groups_60513 120.91 +- 40.81 2 0 2 0 0.17 +- 0.23 2 12

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00704 (2/2) Glycosyl hydrolases family 18
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00722 (1/2) Glycosyl hydrolases family 16
PF00459 (1/2) Inositol monophosphatase family

precursor_groups_212 18.91 +- 0.28 3 0 0 0 0.11 +- 0.10 3 2

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF05685 (3/3) Putative restriction endonuclease

precursor_groups_213 132.57 +- 121.42 15 0 0 1 0.09 +- 0.15 15 2

PF14200 (8/15) Ricin-type beta-trefoil lectin domain-like
PF00652 (8/15) Ricin-type beta-trefoil lectin domain

precursor_groups_24625 782.71 +- 351.28 4 0 0 0 0.03 +- 0.04 4 11

PF18099 (4/4) DUF5010 C-terminal domain
PF13377 (4/4) Periplasmic binding protein-like domain
PF11941 (4/4) Domain of unknown function (DUF3459)
PF10756 (4/4) Bacterial PH domain
PF03663 (4/4) Glycosyl hydrolase family 76
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF00128 (4/4) Alpha amylase, catalytic domain
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00920 (3/4) Dehydratase family

precursor_groups_75237 130.01 +- 0.90 2 0 0 0 0.09 +- 0.16 2 8

TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF13443 (2/2) Cro/C1-type HTH DNA-binding domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00589 (2/2) Phage integrase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_219 21.94 +- 4.78 16 0 4 16 0.17 +- 0.23 16 5

TIGR04187 (16/16) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (16/16) putative ATP-grasp target RiPP
PF14404 (16/16) Ribosomally synthesized peptide in Streptomyces species
PF08242 (9/16) Methyltransferase domain
PF00903 (9/16) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_17615 655.79 +- 464.04 5 0 5 5 0.04 +- 0.14 5 14

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (5/5) SagB-type dehydrogenase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR00711 (5/5) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00630 (5/5) excinuclease ABC subunit A
PF17755 (5/5) UvrA DNA-binding domain
PF07730 (5/5) Histidine kinase
PF07690 (5/5) Major Facilitator Superfamily
PF06722 (5/5) Protein of unknown function (DUF1205)
PF04101 (5/5) Glycosyltransferase family 28 C-terminal domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00881 (5/5) Nitroreductase family
PF00190 (5/5) Cupin

precursor_groups_52633 1501.25 +- 318.75 2 0 2 2 0.01 +- 0.00 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR00838 (2/2) argininosuccinate lyase
TIGR00032 (2/2) argininosuccinate synthase
PF14698 (2/2) Argininosuccinate lyase C-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00764 (2/2) Arginosuccinate synthase
PF00733 (2/2) Asparagine synthase
PF00668 (2/2) Condensation domain
PF00581 (2/2) Rhodanese-like domain
PF00578 (2/2) AhpC/TSA family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00206 (2/2) Lyase
PF04299 (1/2) Putative FMN-binding domain
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain

precursor_groups_26914 268.55 +- 266.44 3 0 0 0 0.06 +- 0.12 3 5

TIGR03620 (3/3) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF12802 (3/3) MarR family
PF07859 (3/3) alpha/beta hydrolase fold
PF06441 (3/3) Epoxide hydrolase N terminus
PF00561 (3/3) alpha/beta hydrolase fold

precursor_groups_2170 13.36 +- 0.00 2 0 0 0 0.22 +- 0.33 2 8

TIGR02412 (2/2) aminopeptidase N
PF17900 (2/2) Peptidase M1 N-terminal domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13384 (2/2) Homeodomain-like domain
PF11838 (2/2) ERAP1-like C-terminal domain
PF04402 (2/2) Protein of unknown function (DUF541)
PF01433 (2/2) Peptidase family M1 domain
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain

precursor_groups_22662 328.72 +- 190.80 4 0 0 0 0.02 +- 0.02 4 9

TIGR00167 (4/4) ketose-bisphosphate aldolase
PF17042 (4/4) Nucleotide-binding C-terminal domain
PF14833 (4/4) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF03446 (4/4) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (4/4) GntP family permease
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00392 (4/4) Bacterial regulatory proteins, gntR family

precursor_groups_22661 148.01 +- 74.73 4 0 0 0 0.22 +- 0.28 4 19

TIGR00765 (4/4) YihY family inner membrane protein
TIGR00105 (4/4) ribosomal protein bL31
PF11941 (4/4) Domain of unknown function (DUF3459)
PF05922 (4/4) Peptidase inhibitor I9
PF03631 (4/4) Virulence factor BrkB
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01756 (4/4) Acyl-CoA oxidase
PF01497 (4/4) Periplasmic binding protein
PF01197 (4/4) Ribosomal protein L31
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00128 (4/4) Alpha amylase, catalytic domain
PF00082 (4/4) Subtilase family
PF07705 (3/4) CARDB
PF00754 (3/4) F5/8 type C domain
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF01032 (2/4) FecCD transport family
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00005 (2/4) ABC transporter

precursor_groups_43253 412.46 +- 267.73 3 0 2 0 0.04 +- 0.07 3 9

PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF13377 (2/3) Periplasmic binding protein-like domain
PF10022 (2/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08220 (2/3) DeoR-like helix-turn-helix domain
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01547 (2/3) Bacterial extracellular solute-binding protein
PF01261 (2/3) Xylose isomerase-like TIM barrel
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component

precursor_groups_68425 304.14 +- 106.31 2 0 2 0 0.02 +- 0.03 2 7

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF04820 (2/2) Tryptophan halogenase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01613 (2/2) Flavin reductase like domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain

precursor_groups_17570 784.45 +- 536.54 5 0 0 0 0.03 +- 0.02 5 6

PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF08666 (3/5) SAF domain

precursor_groups_57829 277.15 +- 78.93 2 0 0 0 0.04 +- 0.06 2 10

TIGR01300 (2/2) monovalent cation/proton antiporter, MnhG/PhaG subunit
PF13244 (2/2) Domain of unknown function (DUF4040)
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04066 (2/2) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (2/2) Domain related to MnhB subunit of Na+/H+ antiporter
PF03334 (2/2) Na+/H+ antiporter subunit
PF01899 (2/2) Na+/H+ ion antiporter subunit
PF00662 (2/2) NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
PF00420 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (2/2) Proton-conducting membrane transporter

precursor_groups_65519 181.59 +- 0.00 2 0 0 0 0.06 +- 0.08 2 10

TIGR00218 (2/2) mannose-6-phosphate isomerase, class I
PF13377 (2/2) Periplasmic binding protein-like domain
PF13205 (2/2) Bacterial Ig-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF03425 (2/2) Carbohydrate binding domain (family 11)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01238 (2/2) Phosphomannose isomerase type I
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_55681 451.50 +- 193.50 2 0 2 0 0.01 +- 0.00 2 8

PF07883 (2/2) Cupin domain
PF01761 (2/2) 3-dehydroquinate synthase
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_52555 366.83 +- 20.17 2 0 2 0 0.01 +- 0.01 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_30234 43.69 +- 3.22 2 0 0 0 0.09 +- 0.08 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00135 (2/2) Carboxylesterase family
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_19541 53.24 +- 23.79 5 0 5 0 0.09 +- 0.06 5 6

TIGR00797 (5/5) MATE efflux family protein
PF02784 (5/5) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (5/5) MatE
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme

precursor_groups_18361 134.53 +- 90.94 3 0 0 0 0.03 +- 0.04 3 2

PF08877 (3/3) MepB protein
PF00501 (3/3) AMP-binding enzyme

precursor_groups_75018 569.60 +- 92.22 2 0 0 0 0.03 +- 0.02 2 15

TIGR00217 (2/2) 4-alpha-glucanotransferase
PF08323 (2/2) Starch synthase catalytic domain
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07883 (2/2) Cupin domain
PF06182 (2/2) ABC-2 family transporter protein
PF04321 (2/2) RmlD substrate binding domain
PF02446 (2/2) 4-alpha-glucanotransferase
PF01761 (2/2) 3-dehydroquinate synthase
PF00483 (2/2) Nucleotidyl transferase
PF00480 (2/2) ROK family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR01484 (1/2) HAD hydrolase, family IIB
TIGR00099 (1/2) Cof-like hydrolase

precursor_groups_19819 39.69 +- 13.37 2 0 0 0 0.19 +- 0.32 2 7

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (2/2) ABC transporter transmembrane region
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter

precursor_groups_79477 1102.36 +- 187.64 2 0 0 0 0.02 +- 0.02 2 9

PF03706 (2/2) Lysylphosphatidylglycerol synthase TM region
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF03176 (2/2) MMPL family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01040 (2/2) UbiA prenyltransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00248 (2/2) Aldo/keto reductase family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_25170 191.07 +- 76.21 4 0 0 0 0.01 +- 0.01 4 2

PF13602 (4/4) Zinc-binding dehydrogenase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain

precursor_groups_28299 313.28 +- 231.83 4 0 0 0 0.03 +- 0.04 4 6

TIGR01751 (4/4) crotonyl-CoA carboxylase/reductase
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF01047 (4/4) MarR family
PF00857 (4/4) Isochorismatase family
PF00107 (4/4) Zinc-binding dehydrogenase

precursor_groups_38091 60.75 +- 34.52 3 0 0 0 0.09 +- 0.06 3 5

PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF05222 (3/3) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (3/3) Saccharopine dehydrogenase NADP binding domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01266 (3/3) FAD dependent oxidoreductase

precursor_groups_84559 51.53 +- 29.25 2 0 0 0 0.12 +- 0.20 2 5

PF14435 (2/2) SUKH-4 immunity protein
PF07690 (2/2) Major Facilitator Superfamily
PF01872 (2/2) RibD C-terminal domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01206 (2/2) Sulfurtransferase TusA

precursor_groups_42674 255.64 +- 55.48 3 0 0 0 0.09 +- 0.22 3 21

TIGR01928 (3/3) o-succinylbenzoate synthase
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (3/3) Enolase C-terminal domain-like
PF12831 (3/3) FAD dependent oxidoreductase
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (3/3) CoA-transferase family III
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF01546 (3/3) Peptidase family M20/M25/M40
PF01381 (3/3) Helix-turn-helix
PF01380 (3/3) SIS domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (3/3) Enoyl-CoA hydratase/isomerase
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter

precursor_groups_25464 62.47 +- 18.15 2 0 0 0 0.05 +- 0.07 2 6

PF14100 (2/2) Methane oxygenase PmoA
PF13229 (2/2) Right handed beta helix region
PF07602 (2/2) Protein of unknown function (DUF1565)
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_84552 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family

precursor_groups_43390 976.74 +- 313.62 3 0 3 0 0.02 +- 0.03 3 5

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF01593 (3/3) Flavin containing amine oxidoreductase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter

precursor_groups_17805 31.74 +- 11.90 3 0 3 0 0.19 +- 0.30 3 19

TIGR02350 (3/3) chaperone protein DnaK
PF17765 (3/3) MmyB-like transcription regulator ligand binding domain
PF13560 (3/3) Helix-turn-helix domain
PF02797 (3/3) Chalcone and stilbene synthases, C-terminal domain
PF01025 (3/3) GrpE
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00195 (3/3) Chalcone and stilbene synthases, N-terminal domain
PF00067 (3/3) Cytochrome P450
PF00012 (3/3) Hsp70 protein
PF09129 (2/3) Cholesterol oxidase, substrate-binding
PF06386 (2/3) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (2/3) Gas vesicle synthesis protein GvpO
PF05121 (2/3) Gas vesicle protein K
PF05120 (2/3) Gas vesicle protein G
PF03364 (2/3) Polyketide cyclase / dehydrase and lipid transport
PF02371 (2/3) Transposase IS116/IS110/IS902 family
PF01565 (2/3) FAD binding domain
PF01548 (2/3) Transposase
PF00741 (2/3) Gas vesicle protein

precursor_groups_22592 56.89 +- 19.03 4 0 0 0 0.13 +- 0.16 4 4

TIGR01484 (4/4) HAD hydrolase, family IIB
PF08282 (4/4) haloacid dehalogenase-like hydrolase
PF04149 (4/4) Domain of unknown function (DUF397)
PF00353 (4/4) RTX calcium-binding nonapeptide repeat (4 copies)

precursor_groups_44638 393.40 +- 239.84 3 0 3 0 0.12 +- 0.31 3 20

TIGR02039 (3/3) sulfate adenylyltransferase, small subunit
TIGR02034 (3/3) sulfate adenylyltransferase, large subunit
TIGR00670 (3/3) aspartate carbamoyltransferase
TIGR00455 (3/3) adenylyl-sulfate kinase
PF13714 (3/3) Phosphoenolpyruvate phosphomutase
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02729 (3/3) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01583 (3/3) Adenylylsulphate kinase
PF01507 (3/3) Phosphoadenosine phosphosulfate reductase family
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00459 (3/3) Inositol monophosphatase family
PF00326 (3/3) Prolyl oligopeptidase family
PF00185 (3/3) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00171 (3/3) Aldehyde dehydrogenase family
PF00155 (3/3) Aminotransferase class I and II
PF00009 (3/3) Elongation factor Tu GTP binding domain

precursor_groups_22594 246.65 +- 115.26 5 0 4 0 0.08 +- 0.12 5 17

TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00550 (5/5) Phosphopantetheine attachment site
TIGR01746 (4/5) thioester reductase domain
TIGR01733 (4/5) amino acid adenylation domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF07993 (4/5) Male sterility protein
PF01497 (4/5) Periplasmic binding protein
PF01032 (4/5) FecCD transport family
PF00668 (4/5) Condensation domain
PF00501 (4/5) AMP-binding enzyme
PF00005 (4/5) ABC transporter

precursor_groups_19388 1067.58 +- 749.15 4 0 0 0 0.01 +- 0.00 4 7

TIGR03921 (4/4) type VII secretion-associated serine protease mycosin
TIGR03919 (4/4) type VII secretion protein EccB
PF06259 (4/4) Alpha/beta hydrolase
PF05108 (4/4) Type VII secretion system ESX-1, transport TM domain B
PF00082 (4/4) Subtilase family
TIGR03930 (2/4) WXG100 family type VII secretion target
PF06013 (2/4) Proteins of 100 residues with WXG

precursor_groups_76861 81.58 +- 1.73 2 0 0 0 0.17 +- 0.18 2 16

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13847 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450

precursor_groups_22598 34.09 +- 15.72 3 0 0 0 0.17 +- 0.24 3 7

PF00082 (3/3) Subtilase family
PF00005 (3/3) ABC transporter
PF17964 (2/3) Bacterial Ig domain
PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF03734 (2/3) L,D-transpeptidase catalytic domain
PF02687 (2/3) FtsX-like permease family
PF01152 (2/3) Bacterial-like globin

precursor_groups_2630 627.16 +- 526.35 5 0 5 2 0.03 +- 0.05 5 7

PF13527 (5/5) Acetyltransferase (GNAT) domain
PF07690 (5/5) Major Facilitator Superfamily
PF17668 (3/5) Acetyltransferase (GNAT) domain
PF13530 (3/5) Sterol carrier protein domain
PF00553 (3/5) Cellulose binding domain
PF00457 (3/5) Glycosyl hydrolases family 11
PF00069 (3/5) Protein kinase domain

precursor_groups_2515 339.13 +- 0.00 3 0 0 0 0.03 +- 0.01 3 8

TIGR00574 (3/3) DNA ligase I, ATP-dependent (dnl1)
PF04679 (3/3) ATP dependent DNA ligase C terminal region
PF04675 (3/3) DNA ligase N terminus
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01380 (3/3) SIS domain
PF01068 (3/3) ATP dependent DNA ligase domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00294 (3/3) pfkB family carbohydrate kinase

precursor_groups_59374 362.16 +- 87.26 2 0 1 2 0.09 +- 0.10 2 29

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF13586 (2/2) Transposase DDE domain
PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
PF00005 (2/2) ABC transporter
PF17851 (1/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF14100 (1/2) Methane oxygenase PmoA
PF08279 (1/2) HTH domain
PF05331 (1/2) Protein of unknown function (DUF742)
PF04616 (1/2) Glycosyl hydrolases family 43
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01590 (1/2) GAF domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00723 (1/2) Glycosyl hydrolases family 15
PF00544 (1/2) Pectate lyase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_56660 1186.17 +- 232.83 2 0 2 2 0.01 +- 0.00 2 13

PF13580 (2/2) SIS domain
PF08544 (2/2) GHMP kinases C terminal
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF01761 (2/2) 3-dehydroquinate synthase
PF01555 (2/2) DNA methylase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01087 (2/2) Galactose-1-phosphate uridyl transferase, N-terminal domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00535 (2/2) Glycosyl transferase family 2
PF00288 (2/2) GHMP kinases N terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_42811 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease

precursor_groups_6259 38.45 +- 2.83 2 0 1 1 0.11 +- 0.21 2 9

PF00069 (2/2) Protein kinase domain
PF14033 (1/2) Protein of unknown function (DUF4246)
PF05199 (1/2) GMC oxidoreductase
PF05147 (1/2) Lanthionine synthetase C-like protein
PF01734 (1/2) Patatin-like phospholipase
PF01590 (1/2) GAF domain
PF01425 (1/2) Amidase
PF00732 (1/2) GMC oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family

precursor_groups_6258 43.66 +- 3.32 5 0 0 0 0.23 +- 0.32 5 12

TIGR03177 (5/5) Flp pilus assembly protein CpaB
PF16976 (5/5) Flp pilus assembly protein RcpC/CpaB
PF13614 (5/5) AAA domain
PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF07730 (5/5) Histidine kinase
PF04964 (5/5) Flp/Fap pilin component
PF00691 (5/5) OmpA family
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00072 (5/5) Response regulator receiver domain

precursor_groups_6708 17.46 +- 8.51 3 0 2 0 0.17 +- 0.21 3 4

PF01061 (3/3) ABC-2 type transporter
PF00498 (3/3) FHA domain
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter

precursor_groups_43381 30.89 +- 14.64 2 0 0 0 0.13 +- 0.13 2 4

TIGR01356 (2/2) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00275 (2/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00067 (1/2) Cytochrome P450

precursor_groups_73979 1281.00 +- 525.00 2 0 0 0 0.02 +- 0.02 2 9

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF06889 (2/2) Protein of unknown function (DUF1266)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein

precursor_groups_6701 382.54 +- 121.74 9 0 7 9 0.01 +- 0.00 9 4

PF07690 (9/9) Major Facilitator Superfamily
PF05711 (9/9) Macrocin-O-methyltransferase (TylF)
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF13649 (8/9) Methyltransferase domain

precursor_groups_78278 55.60 +- 12.20 2 0 2 0 0.17 +- 0.17 2 10

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00288 (2/2) GHMP kinases N terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_5499 156.60 +- 58.07 6 0 0 0 0.08 +- 0.13 6 7

PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12680 (6/6) SnoaL-like domain
PF07045 (6/6) Domain of unknown function (DUF1330)
PF01738 (6/6) Dienelactone hydrolase family
PF00664 (6/6) ABC transporter transmembrane region
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00005 (6/6) ABC transporter

precursor_groups_75491 55.28 +- 3.51 2 0 2 0 0.18 +- 0.16 2 10

PF18029 (2/2) Glyoxalase-like domain
PF18011 (2/2) C-terminal domain found in long catalases
PF13520 (2/2) Amino acid permease
PF13439 (2/2) Glycosyltransferase Family 4
PF06628 (2/2) Catalase-related immune-responsive
PF04101 (2/2) Glycosyltransferase family 28 C-terminal domain
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF00534 (2/2) Glycosyl transferases group 1
PF00199 (2/2) Catalase
PF00005 (2/2) ABC transporter

precursor_groups_17972 375.81 +- 126.83 4 0 3 0 0.03 +- 0.04 4 14

TIGR03619 (4/4) probable F420-dependent oxidoreductase, Rv2161c family
PF14864 (4/4) Alkyl sulfatase C-terminal
PF13847 (4/4) Methyltransferase domain
PF07977 (4/4) FabA-like domain
PF03061 (4/4) Thioesterase superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF14863 (3/4) Alkyl sulfatase dimerisation
PF09076 (3/4) Beta/Gamma crystallin
PF00753 (3/4) Metallo-beta-lactamase superfamily

precursor_groups_42498 141.16 +- 40.59 3 0 0 0 0.03 +- 0.01 3 8

PF13450 (3/3) NAD(P)-binding Rossmann-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00970 (3/3) Oxidoreductase FAD-binding domain
PF00848 (3/3) Ring hydroxylating alpha subunit (catalytic domain)
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_8826 297.74 +- 56.52 4 0 0 0 0.10 +- 0.24 4 16

TIGR01902 (4/4) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (4/4) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (4/4) alpha-L-glutamate ligase, RimK family
PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13535 (4/4) ATP-grasp domain
PF08443 (4/4) RimK-like ATP-grasp domain
PF07690 (4/4) Major Facilitator Superfamily
PF02779 (4/4) Transketolase, pyrimidine binding domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01118 (4/4) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (4/4) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (4/4) Amino acid kinase family
PF00664 (4/4) ABC transporter transmembrane region
PF00456 (4/4) Transketolase, thiamine diphosphate binding domain
PF00005 (4/4) ABC transporter

precursor_groups_55868 774.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 12

TIGR04469 (2/2) CGA synthase-related protein
TIGR04468 (2/2) arginine 2,3-aminomutase
TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (2/2) cytosylglucuronate decarboxylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF12833 (2/2) Helix-turn-helix domain
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00069 (2/2) Protein kinase domain

precursor_groups_10810 164.13 +- 95.58 6 0 4 5 0.02 +- 0.02 6 2

PF00296 (6/6) Luciferase-like monooxygenase
PF05147 (5/6) Lanthionine synthetase C-like protein

precursor_groups_68646 131.16 +- 62.34 2 0 0 0 0.03 +- 0.03 2 4

PF18370 (2/2) Rhamnogalacturonan I lyases beta-sheet domain
PF10503 (2/2) Esterase PHB depolymerase
PF07690 (2/2) Major Facilitator Superfamily
PF00067 (2/2) Cytochrome P450

precursor_groups_52 45.71 +- 13.04 11 0 0 0 0.22 +- 0.38 11 6

PF05175 (9/11) Methyltransferase small domain
TIGR00041 (8/11) dTMP kinase
PF12840 (8/11) Helix-turn-helix domain
PF02223 (8/11) Thymidylate kinase
PF01061 (8/11) ABC-2 type transporter
PF00005 (8/11) ABC transporter

precursor_groups_18635 589.17 +- 92.80 2 0 2 0 0.03 +- 0.04 2 17

PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00106 (2/2) short chain dehydrogenase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16864 (1/2) Dimerisation domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF05598 (1/2) Transposase domain (DUF772)
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03704 (1/2) Bacterial transcriptional activator domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01738 (1/2) Dienelactone hydrolase family
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00072 (1/2) Response regulator receiver domain

precursor_groups_18141 83.61 +- 15.11 2 0 0 0 0.19 +- 0.16 2 9

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13410 (2/2) Glutathione S-transferase, C-terminal domain
PF08445 (2/2) FR47-like protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00497 (2/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF00196 (1/2) Bacterial regulatory proteins, luxR family

precursor_groups_18633 1256.88 +- 765.49 5 0 5 0 0.03 +- 0.10 5 15

TIGR01733 (5/5) amino acid adenylation domain
PF13560 (5/5) Helix-turn-helix domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF07690 (5/5) Major Facilitator Superfamily
PF06368 (5/5) Methylaspartate mutase E chain (MutE)
PF03621 (5/5) MbtH-like protein
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (5/5) B12 binding domain
PF01648 (5/5) 4'-phosphopantetheinyl transferase superfamily
PF01645 (5/5) Conserved region in glutamate synthase
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00152 (5/5) tRNA synthetases class II (D, K and N)

precursor_groups_83016 2580.00 +- 0.00 2 0 2 2 0.01 +- 0.00 2 6

TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (2/2) ABC-2 type transporter
PF00733 (2/2) Asparagine synthase
PF00005 (2/2) ABC transporter

precursor_groups_3774 122.92 +- 7.08 2 0 1 0 0.06 +- 0.12 2 16

TIGR00344 (2/2) alanine--tRNA ligase
PF07973 (2/2) Threonyl and Alanyl tRNA synthetase second additional domain
PF02272 (2/2) DHHA1 domain
PF01411 (2/2) tRNA synthetases class II (A)
TIGR01733 (1/2) amino acid adenylation domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18306 (1/2) SLOG cluster4 family
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF07730 (1/2) Histidine kinase
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01061 (1/2) ABC-2 type transporter
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00501 (1/2) AMP-binding enzyme
PF00156 (1/2) Phosphoribosyl transferase domain
PF00005 (1/2) ABC transporter

precursor_groups_59378 71.47 +- 16.87 2 0 0 0 0.13 +- 0.09 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF04672 (2/2) S-adenosyl methyltransferase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00480 (2/2) ROK family

precursor_groups_7073 635.55 +- 515.64 10 0 10 10 0.04 +- 0.18 10 7

TIGR03891 (10/10) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (10/10) Lantibiotic biosynthesis dehydratase C-term
PF05147 (10/10) Lanthionine synthetase C-like protein
PF04738 (10/10) Lantibiotic dehydratase, N terminus
PF00664 (8/10) ABC transporter transmembrane region
PF00005 (8/10) ABC transporter
PF13302 (7/10) Acetyltransferase (GNAT) domain

precursor_groups_49871 387.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_57463 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR01473 (2/2) protoheme IX farnesyltransferase
PF04261 (2/2) Dyp-type peroxidase family
PF01040 (2/2) UbiA prenyltransferase family
TIGR01413 (1/2) Dyp-type peroxidase family

precursor_groups_44971 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase

precursor_groups_11897 174.14 +- 108.66 6 0 5 0 0.02 +- 0.02 6 4

PF10067 (6/6) Predicted membrane protein (DUF2306)
PF08240 (6/6) Alcohol dehydrogenase GroES-like domain
PF00107 (6/6) Zinc-binding dehydrogenase
PF00067 (6/6) Cytochrome P450

precursor_groups_43033 447.68 +- 277.08 3 0 2 0 0.03 +- 0.03 3 6

PF05426 (3/3) Alginate lyase
PF05345 (3/3) Putative Ig domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00295 (3/3) Glycosyl hydrolases family 28
PF00135 (2/3) Carboxylesterase family

precursor_groups_43031 463.67 +- 229.67 2 0 1 0 0.06 +- 0.11 2 12

PF13822 (1/2) Acyl-CoA carboxylase epsilon subunit
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF03704 (1/2) Bacterial transcriptional activator domain
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (1/2) Phosphotransferase enzyme family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00067 (1/2) Cytochrome P450

precursor_groups_54791 670.50 +- 103.50 2 0 0 0 0.04 +- 0.04 2 7

TIGR01972 (2/2) proton-translocating NADH-quinone oxidoreductase, chain M
PF01850 (2/2) PIN domain
PF00361 (2/2) Proton-conducting membrane transporter
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00146 (1/2) NADH dehydrogenase

precursor_groups_82520 33.33 +- 1.07 2 0 0 0 0.06 +- 0.01 2 1

PF00106 (2/2) short chain dehydrogenase

precursor_groups_22284 576.00 +- 176.39 5 0 0 5 0.01 +- 0.00 5 4

PF13649 (5/5) Methyltransferase domain
PF13578 (5/5) Methyltransferase domain
PF09860 (5/5) Uncharacterized protein conserved in bacteria (DUF2087)
PF04055 (5/5) Radical SAM superfamily

precursor_groups_14872 56.27 +- 26.59 7 0 7 0 0.14 +- 0.18 7 6

PF11991 (7/7) Tryptophan dimethylallyltransferase
PF01212 (7/7) Beta-eliminating lyase
PF05331 (4/7) Protein of unknown function (DUF742)
PF03259 (4/7) Roadblock/LC7 domain
PF03029 (4/7) Conserved hypothetical ATP binding protein
PF02518 (4/7) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

precursor_groups_11506 129.40 +- 68.70 2 0 0 0 0.10 +- 0.19 2 20

PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01494 (2/2) FAD binding domain
PF00248 (2/2) Aldo/keto reductase family
PF00106 (2/2) short chain dehydrogenase
PF13936 (1/2) Helix-turn-helix domain
PF13683 (1/2) Integrase core domain
PF13006 (1/2) Insertion element 4 transposase N-terminal
PF12900 (1/2) Pyridoxamine 5'-phosphate oxidase
PF12840 (1/2) Helix-turn-helix domain
PF03831 (1/2) PhnA domain
PF01740 (1/2) STAS domain
PF01609 (1/2) Transposase DDE domain
PF01527 (1/2) Transposase
PF00916 (1/2) Sulfate permease family
PF00665 (1/2) Integrase core domain

precursor_groups_34403 32.91 +- 4.54 2 0 2 0 0.19 +- 0.29 2 8

PF13410 (2/2) Glutathione S-transferase, C-terminal domain
PF13409 (2/2) Glutathione S-transferase, N-terminal domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF13230 (2/2) Glutamine amidotransferases class-II
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00722 (2/2) Glycosyl hydrolases family 16
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_10589 155.05 +- 102.95 2 0 2 0 0.04 +- 0.06 2 23

TIGR04020 (2/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08241 (2/2) Methyltransferase domain
PF07993 (2/2) Male sterility protein
PF01695 (2/2) IstB-like ATP binding protein
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00665 (2/2) Integrase core domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00296 (2/2) Luciferase-like monooxygenase
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF14765 (1/2) Polyketide synthase dehydratase
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF03358 (1/2) NADPH-dependent FMN reductase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (1/2) Thioesterase domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase

precursor_groups_30255 87.84 +- 10.44 2 0 0 0 0.05 +- 0.07 2 9

PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF08002 (2/2) Protein of unknown function (DUF1697)
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01323 (2/2) DSBA-like thioredoxin domain
TIGR03086 (1/2) TIGR03086 family protein
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2

precursor_groups_30257 48.73 +- 19.77 4 0 1 0 0.09 +- 0.09 4 4

PF11512 (4/4) Agrobacterium tumefaciens protein Atu4866
PF07690 (4/4) Major Facilitator Superfamily
PF01979 (4/4) Amidohydrolase family
PF07702 (3/4) UTRA domain

precursor_groups_30256 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 4

PF13649 (2/2) Methyltransferase domain
PF13560 (2/2) Helix-turn-helix domain
PF06325 (2/2) Ribosomal protein L11 methyltransferase (PrmA)
PF04149 (2/2) Domain of unknown function (DUF397)

precursor_groups_27955 63.27 +- 4.03 2 0 0 0 0.10 +- 0.12 2 5

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF02655 (1/2) ATP-grasp domain

precursor_groups_82777 559.00 +- 215.00 2 0 2 0 0.01 +- 0.01 2 10

PF13424 (2/2) Tetratricopeptide repeat
PF13394 (2/2) 4Fe-4S single cluster domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01242 (2/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (2/2) GTP cyclohydrolase I
PF00931 (2/2) NB-ARC domain
PF00478 (2/2) IMP dehydrogenase / GMP reductase domain
PF00293 (2/2) NUDIX domain
PF00156 (2/2) Phosphoribosyl transferase domain

precursor_groups_86570 51.79 +- 15.31 2 0 0 0 0.17 +- 0.20 2 9

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR00996 (2/2) virulence factor Mce family protein
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter

precursor_groups_10585 524.78 +- 612.66 9 0 9 0 0.05 +- 0.16 9 11

TIGR01509 (9/9) HAD hydrolase, family IA, variant 3
TIGR00652 (9/9) diaminopimelate epimerase
PF18130 (9/9) ATP-grasp N-terminal domain
PF14518 (9/9) Iron-containing redox enzyme
PF13535 (9/9) ATP-grasp domain
PF13419 (9/9) Haloacid dehalogenase-like hydrolase
PF10014 (9/9) 2OG-Fe dioxygenase
PF07690 (9/9) Major Facilitator Superfamily
PF02585 (9/9) GlcNAc-PI de-N-acetylase
PF01678 (9/9) Diaminopimelate epimerase
PF00155 (9/9) Aminotransferase class I and II

precursor_groups_3602 451.91 +- 137.60 5 0 5 5 0.01 +- 0.01 5 6

TIGR04364 (5/5) methyltransferase, FxLD system
TIGR03891 (5/5) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF05147 (5/5) Lanthionine synthetase C-like protein
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF01135 (5/5) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

precursor_groups_14082 205.39 +- 158.89 5 0 5 0 0.05 +- 0.04 5 13

PF16197 (5/5) Ketoacyl-synthetase C-terminal extension
PF07690 (5/5) Major Facilitator Superfamily
PF02801 (5/5) Beta-ketoacyl synthase, C-terminal domain
PF00698 (5/5) Acyl transferase domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
PF00109 (5/5) Beta-ketoacyl synthase, N-terminal domain
TIGR04020 (4/5) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/5) amino acid adenylation domain
PF13193 (4/5) AMP-binding enzyme C-terminal domain
PF00668 (4/5) Condensation domain
PF00501 (4/5) AMP-binding enzyme
PF00296 (4/5) Luciferase-like monooxygenase

precursor_groups_28438 134.45 +- 23.20 3 0 3 0 0.08 +- 0.11 3 12

TIGR04498 (3/3) abortive infection protein, AbiV family
PF18728 (3/3) AbiV
PF03711 (3/3) Orn/Lys/Arg decarboxylase, C-terminal domain
PF03709 (3/3) Orn/Lys/Arg decarboxylase, N-terminal domain
PF02371 (3/3) Transposase IS116/IS110/IS902 family
PF01609 (3/3) Transposase DDE domain
PF01548 (3/3) Transposase
PF01276 (3/3) Orn/Lys/Arg decarboxylase, major domain
PF00494 (3/3) Squalene/phytoene synthase
PF00348 (3/3) Polyprenyl synthetase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (3/3) ABC transporter

precursor_groups_22846 148.56 +- 106.11 5 0 0 5 0.10 +- 0.14 5 16

TIGR04283 (5/5) transferase 2, rSAM/selenodomain-associated
TIGR04282 (5/5) transferase 1, rSAM/selenodomain-associated
PF12850 (5/5) Calcineurin-like phosphoesterase superfamily domain
PF09837 (5/5) Uncharacterized protein conserved in bacteria (DUF2064)
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04055 (5/5) Radical SAM superfamily
PF02852 (5/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF02687 (5/5) FtsX-like permease family
PF01048 (5/5) Phosphorylase superfamily
PF00535 (5/5) Glycosyl transferase family 2
PF00005 (5/5) ABC transporter
PF00672 (4/5) HAMP domain
PF00512 (4/5) His Kinase A (phospho-acceptor) domain
PF00486 (4/5) Transcriptional regulatory protein, C terminal
PF00072 (4/5) Response regulator receiver domain
PF07291 (3/5) Methylamine utilisation protein MauE

precursor_groups_53315 258.43 +- 108.63 2 0 0 0 0.04 +- 0.04 2 7

PF14525 (2/2) AraC-binding-like domain
PF13191 (2/2) AAA ATPase domain
PF12833 (2/2) Helix-turn-helix domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF07690 (2/2) Major Facilitator Superfamily
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_3594 526.85 +- 513.15 2 0 1 0 0.08 +- 0.16 2 24

TIGR02149 (1/2) glycogen synthase, Corynebacterium family
TIGR02091 (1/2) glucose-1-phosphate adenylyltransferase
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00838 (1/2) argininosuccinate lyase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14698 (1/2) Argininosuccinate lyase C-terminal
PF13535 (1/2) ATP-grasp domain
PF13439 (1/2) Glycosyltransferase Family 4
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF06276 (1/2) Ferric iron reductase FhuF-like transporter
PF03621 (1/2) MbtH-like protein
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00483 (1/2) Nucleotidyl transferase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00288 (1/2) GHMP kinases N terminal domain
PF00206 (1/2) Lyase

precursor_groups_3597 68.65 +- 72.99 5 0 0 0 0.08 +- 0.09 5 4

PF14200 (5/5) Ricin-type beta-trefoil lectin domain-like
PF09997 (5/5) Predicted membrane protein (DUF2238)
PF05270 (5/5) Alpha-L-arabinofuranosidase B (ABFB) domain
PF04616 (5/5) Glycosyl hydrolases family 43

precursor_groups_29818 650.81 +- 12.62 2 0 0 0 0.01 +- 0.01 2 5

PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter

precursor_groups_65234 239.03 +- 147.97 2 0 1 0 0.02 +- 0.03 2 3

PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF07690 (2/2) Major Facilitator Superfamily
PF00487 (2/2) Fatty acid desaturase

precursor_groups_44991 1206.67 +- 117.85 3 0 3 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF05114 (3/3) Protein of unknown function (DUF692)
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF06999 (2/3) Sucrase/ferredoxin-like

precursor_groups_71105 777.00 +- 3.00 2 0 2 0 0.01 +- 0.00 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00067 (2/2) Cytochrome P450

precursor_groups_6671 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_12528 119.62 +- 68.02 2 0 0 0 0.05 +- 0.07 2 6

PF14759 (2/2) Reductase C-terminal
PF13459 (2/2) 4Fe-4S single cluster domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01636 (2/2) Phosphotransferase enzyme family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter

precursor_groups_43727 62.67 +- 21.49 3 0 0 0 0.09 +- 0.12 3 6

PF13378 (3/3) Enolase C-terminal domain-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_23225 93.60 +- 84.83 2 0 0 0 0.15 +- 0.14 2 7

TIGR01048 (2/2) diaminopimelate decarboxylase
PF04616 (2/2) Glycosyl hydrolases family 43
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF17851 (1/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10

precursor_groups_7277 206.03 +- 75.99 7 0 2 5 0.06 +- 0.11 7 4

PF04828 (4/7) Glutathione-dependent formaldehyde-activating enzyme
PF02274 (4/7) Amidinotransferase
PF00999 (4/7) Sodium/hydrogen exchanger family
PF00881 (4/7) Nitroreductase family

precursor_groups_66987 27.36 +- 2.87 2 0 0 0 0.11 +- 0.06 2 7

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family

precursor_groups_4817 283.90 +- 336.53 15 0 0 0 0.09 +- 0.22 15 12

PF03706 (15/15) Lysylphosphatidylglycerol synthase TM region
PF03372 (15/15) Endonuclease/Exonuclease/phosphatase family
PF01370 (15/15) NAD dependent epimerase/dehydratase family
PF01040 (15/15) UbiA prenyltransferase family
PF00535 (15/15) Glycosyl transferase family 2
PF00248 (15/15) Aldo/keto reductase family
PF00202 (15/15) Aminotransferase class-III
PF00196 (15/15) Bacterial regulatory proteins, luxR family
PF11755 (9/15) Protein of unknown function (DUF3311)
PF00583 (9/15) Acetyltransferase (GNAT) family
PF00474 (9/15) Sodium:solute symporter family
PF03176 (8/15) MMPL family

precursor_groups_66981 405.53 +- 129.77 2 0 2 0 0.03 +- 0.04 2 18

TIGR02087 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01063 (2/2) Amino-transferase class IV
PF00850 (2/2) Histone deacetylase domain
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00425 (2/2) chorismate binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00117 (2/2) Glutamine amidotransferase class-I

precursor_groups_59171 148.71 +- 51.96 2 0 0 0 0.05 +- 0.05 2 6

PF14279 (2/2) HNH endonuclease
PF13560 (2/2) Helix-turn-helix domain
PF13408 (2/2) Recombinase zinc beta ribbon domain
PF07508 (2/2) Recombinase
PF02796 (2/2) Helix-turn-helix domain of resolvase
PF00239 (2/2) Resolvase, N terminal domain

precursor_groups_15331 127.39 +- 21.46 2 0 0 0 0.12 +- 0.18 2 15

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13407 (2/2) Periplasmic binding protein domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF04199 (2/2) Putative cyclase
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
PF00575 (1/2) S1 RNA binding domain

precursor_groups_65298 126.63 +- 34.90 2 0 2 0 0.12 +- 0.15 2 7

PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00037 (2/2) 4Fe-4S binding domain

precursor_groups_10742 188.27 +- 75.50 4 0 0 0 0.06 +- 0.04 4 8

PF13416 (4/4) Bacterial extracellular solute-binding protein
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00266 (4/4) Aminotransferase class-V
PF17831 (2/4) Pyruvate dehydrogenase E1 component middle domain
PF12697 (2/4) Alpha/beta hydrolase family
PF07992 (2/4) Pyridine nucleotide-disulphide oxidoreductase
PF02467 (2/4) Transcription factor WhiB
PF00456 (2/4) Transketolase, thiamine diphosphate binding domain

precursor_groups_54136 322.67 +- 93.33 2 0 0 0 0.01 +- 0.01 2 4

PF12006 (2/2) Protein of unknown function (DUF3500)
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF01168 (2/2) Alanine racemase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase

precursor_groups_61750 532.30 +- 265.64 2 0 2 0 0.12 +- 0.26 2 28

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
TIGR00223 (2/2) aspartate 1-decarboxylase
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13847 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF13358 (2/2) DDE superfamily endonuclease
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF02261 (2/2) Aspartate decarboxylase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_9851 126.89 +- 24.86 7 0 4 0 0.03 +- 0.02 7 6

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF07690 (7/7) Major Facilitator Superfamily
PF01238 (7/7) Phosphomannose isomerase type I
PF00282 (7/7) Pyridoxal-dependent decarboxylase conserved domain
PF07729 (4/7) FCD domain
PF00392 (4/7) Bacterial regulatory proteins, gntR family

precursor_groups_9857 630.67 +- 254.09 3 0 0 0 0.03 +- 0.03 3 14

PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF13472 (3/3) GDSL-like Lipase/Acylhydrolase family
PF13416 (3/3) Bacterial extracellular solute-binding protein
PF13377 (3/3) Periplasmic binding protein-like domain
PF08533 (3/3) Beta-galactosidase C-terminal domain
PF08532 (3/3) Beta-galactosidase trimerisation domain
PF02449 (3/3) Beta-galactosidase
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00135 (3/3) Carboxylesterase family
PF16499 (2/3) Alpha galactosidase A
PF14508 (2/3) Glycosyl-hydrolase 97 N-terminal
PF06964 (2/3) Alpha-L-arabinofuranosidase C-terminal domain
PF04616 (2/3) Glycosyl hydrolases family 43

precursor_groups_48435 40.66 +- 1.66 2 0 2 0 0.15 +- 0.31 2 9

TIGR02406 (2/2) diaminobutyrate acetyltransferase
TIGR00556 (2/2) phosphopantetheine--protein transferase domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_22932 176.42 +- 64.15 5 0 0 0 0.07 +- 0.05 5 8

PF13416 (5/5) Bacterial extracellular solute-binding protein
PF01266 (5/5) FAD dependent oxidoreductase
PF00005 (5/5) ABC transporter
TIGR01428 (4/5) haloacid dehalogenase, type II
PF13419 (4/5) Haloacid dehalogenase-like hydrolase
PF08402 (4/5) TOBE domain
PF00528 (4/5) Binding-protein-dependent transport system inner membrane component
PF00171 (4/5) Aldehyde dehydrogenase family

precursor_groups_70675 410.42 +- 115.12 2 0 0 0 0.03 +- 0.04 2 16

TIGR00872 (2/2) 6-phosphogluconate dehydrogenase (decarboxylating)
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF14433 (2/2) SUKH-3 immunity protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13401 (2/2) AAA domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF06527 (2/2) TniQ
PF06414 (2/2) Zeta toxin
PF04199 (2/2) Putative cyclase
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00665 (2/2) Integrase core domain
PF00393 (2/2) 6-phosphogluconate dehydrogenase, C-terminal domain
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_59213 364.31 +- 25.69 2 0 0 0 0.01 +- 0.00 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF03061 (2/2) Thioesterase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase

precursor_groups_62249 72.56 +- 4.84 2 0 2 0 0.10 +- 0.21 2 16

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01686 (2/2) FkbH domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_62248 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase

precursor_groups_13224 75.22 +- 56.18 5 0 5 0 0.06 +- 0.06 5 2

PF00156 (5/5) Phosphoribosyl transferase domain
PF00082 (5/5) Subtilase family

precursor_groups_1607 135.29 +- 122.71 2 0 0 0 0.08 +- 0.11 2 5

PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF01477 (1/2) PLAT/LH2 domain
PF01341 (1/2) Glycosyl hydrolases family 6
PF00106 (1/2) short chain dehydrogenase

precursor_groups_62240 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_1605 17.02 +- 3.24 5 0 0 0 0.17 +- 0.16 5 7

TIGR01840 (3/5) esterase, PHB depolymerase family
PF13701 (3/5) Transposase DDE domain group 1
PF10605 (3/5) 3HB-oligomer hydrolase (3HBOH)
PF10503 (3/5) Esterase PHB depolymerase
PF07519 (3/5) Tannase and feruloyl esterase
PF00144 (3/5) Beta-lactamase
PF00041 (3/5) Fibronectin type III domain

precursor_groups_20752 658.02 +- 501.26 5 0 5 0 0.05 +- 0.17 5 8

TIGR01733 (5/5) amino acid adenylation domain
TIGR01720 (5/5) non-ribosomal peptide synthase domain TIGR01720
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF08242 (5/5) Methyltransferase domain
PF00975 (5/5) Thioesterase domain
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme

precursor_groups_23358 140.30 +- 117.70 2 0 0 0 0.05 +- 0.07 2 2

PF10056 (2/2) Uncharacterized conserved protein (DUF2293)
PF08592 (2/2) Domain of unknown function (DUF1772)

precursor_groups_64907 595.60 +- 307.40 2 0 0 0 0.03 +- 0.07 2 16

PF18448 (2/2) Carbohydrate binding domain
PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (2/2) Domain of unknown function(DUF4981)
PF15902 (2/2) Sortilin, neurotensin receptor 3,
PF14310 (2/2) Fibronectin type III-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF04616 (2/2) Glycosyl hydrolases family 43
PF03442 (2/2) Carbohydrate binding domain X2
PF03422 (2/2) Carbohydrate binding module (family 6)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (2/2) Alpha-L-fucosidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_11764 276.38 +- 115.50 6 0 6 0 0.03 +- 0.13 6 9

TIGR00711 (6/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
TIGR00026 (6/6) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13577 (6/6) SnoaL-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF07366 (6/6) SnoaL-like polyketide cyclase
PF03358 (6/6) NADPH-dependent FMN reductase
PF01814 (6/6) Hemerythrin HHE cation binding domain
PF00999 (6/6) Sodium/hydrogen exchanger family
PF00891 (6/6) O-methyltransferase domain

precursor_groups_11765 22.50 +- 3.18 5 0 0 0 0.18 +- 0.17 5 5

PF13564 (5/5) DoxX-like family
PF11139 (5/5) Sap, sulfolipid-1-addressing protein
PF07690 (5/5) Major Facilitator Superfamily
PF04029 (5/5) 2-phosphosulpholactate phosphatase
PF01494 (5/5) FAD binding domain

precursor_groups_20994 916.95 +- 819.52 3 0 0 0 0.02 +- 0.02 3 11

PF13814 (2/3) Replication-relaxation
PF13406 (2/3) Transglycosylase SLT domain
PF13400 (2/3) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/3) AAA-like domain
PF12642 (2/3) Conjugative transposon protein TcpC
PF08666 (2/3) SAF domain
PF07811 (2/3) TadE-like protein
PF01476 (2/3) LysM domain
PF00877 (2/3) NlpC/P60 family
PF00482 (2/3) Type II secretion system (T2SS), protein F
PF00437 (2/3) Type II/IV secretion system protein

precursor_groups_44568 42.04 +- 0.96 2 0 0 0 0.12 +- 0.12 2 7

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02156 (2/2) Glycosyl hydrolase family 26
PF01943 (2/2) Polysaccharide biosynthesis protein
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00005 (2/2) ABC transporter

precursor_groups_90 496.25 +- 1000.57 6 0 2 0 0.10 +- 0.23 6 3

PF04149 (6/6) Domain of unknown function (DUF397)
PF13560 (5/6) Helix-turn-helix domain
PF04672 (5/6) S-adenosyl methyltransferase

precursor_groups_64908 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_82797 107.56 +- 6.94 2 0 2 0 0.13 +- 0.23 2 12

PF13924 (2/2) Lipocalin-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF06902 (2/2) Divergent 4Fe-4S mono-cluster
PF04673 (2/2) Polyketide synthesis cyclase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00067 (2/2) Cytochrome P450
PF17754 (1/2) MftR C-terminal domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_34577 117.22 +- 27.91 2 0 2 0 0.05 +- 0.06 2 13

TIGR01426 (2/2) glycosyltransferase, MGT family
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00664 (2/2) ABC transporter transmembrane region
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_41719 161.20 +- 98.80 2 0 0 0 0.02 +- 0.04 2 6

PF18766 (2/2) SWI2/SNF2 ATPase
PF12161 (2/2) HsdM N-terminal domain
PF04313 (2/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF02384 (2/2) N-6 DNA Methylase
PF01420 (2/2) Type I restriction modification DNA specificity domain
PF00069 (2/2) Protein kinase domain

precursor_groups_61193 106.96 +- 34.94 2 0 0 0 0.07 +- 0.03 2 13

PF17645 (2/2) Arylmalonate decarboxylase
PF12697 (2/2) Alpha/beta hydrolase family
PF06240 (2/2) Carbon monoxide dehydrogenase subunit G (CoxG)
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF01494 (2/2) FAD binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01047 (2/2) MarR family
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00857 (2/2) Isochorismatase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_41714 186.14 +- 8.86 2 0 0 0 0.03 +- 0.01 2 9

PF13808 (2/2) DDE_Tnp_1-associated
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12840 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01609 (2/2) Transposase DDE domain
PF01596 (2/2) O-methyltransferase
PF01494 (2/2) FAD binding domain
PF00581 (2/2) Rhodanese-like domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_14115 18.88 +- 3.69 5 0 0 0 0.22 +- 0.20 5 19

TIGR03346 (5/5) ATP-dependent chaperone protein ClpB
TIGR02350 (5/5) chaperone protein DnaK
TIGR01068 (5/5) thioredoxin
PF17871 (5/5) AAA lid domain
PF13591 (5/5) MerR HTH family regulatory protein
PF13515 (5/5) Fusaric acid resistance protein-like
PF12805 (5/5) FUSC-like inner membrane protein yccS
PF10431 (5/5) C-terminal, D2-small domain, of ClpB protein
PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (5/5) AAA domain (Cdc48 subfamily)
PF02861 (5/5) Clp amino terminal domain, pathogenicity island component
PF02148 (5/5) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (5/5) DnaJ C terminal domain
PF01025 (5/5) GrpE
PF00226 (5/5) DnaJ domain
PF00085 (5/5) Thioredoxin
PF00027 (5/5) Cyclic nucleotide-binding domain
PF00012 (5/5) Hsp70 protein
PF00004 (5/5) ATPase family associated with various cellular activities (AAA)

precursor_groups_81684 24.72 +- 1.08 2 0 0 0 0.16 +- 0.23 2 9

TIGR01031 (2/2) ribosomal protein bL32
PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF04072 (2/2) Leucine carboxyl methyltransferase
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02492 (2/2) CobW/HypB/UreG, nucleotide-binding domain
PF01783 (2/2) Ribosomal L32p protein family
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00005 (2/2) ABC transporter

precursor_groups_41712 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter

precursor_groups_1286 57.33 +- 77.68 7 0 1 0 0.15 +- 0.26 7

No common domains found

precursor_groups_66574 146.17 +- 19.69 2 0 2 0 0.04 +- 0.02 2 12

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450

precursor_groups_49097 107.64 +- 9.63 2 0 2 0 0.09 +- 0.23 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13424 (2/2) Tetratricopeptide repeat
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12770 (2/2) CHAT domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07681 (2/2) DoxX
PF01073 (2/2) 3-beta hydroxysteroid dehydrogenase/isomerase family
PF00704 (2/2) Glycosyl hydrolases family 18
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13808 (1/2) DDE_Tnp_1-associated
PF13545 (1/2) Crp-like helix-turn-helix domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01609 (1/2) Transposase DDE domain

precursor_groups_1282 174.56 +- 122.08 24 0 24 24 0.05 +- 0.03 24 5

TIGR04451 (24/24) lantipeptide, SCO0268 family
TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (24/24) Lantibiotic biosynthesis dehydratase C-term
PF05147 (24/24) Lanthionine synthetase C-like protein
PF04738 (24/24) Lantibiotic dehydratase, N terminus

precursor_groups_29741 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain

precursor_groups_62407 172.67 +- 0.67 2 0 2 0 0.01 +- 0.00 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold

precursor_groups_10463 746.09 +- 12.83 2 0 0 0 0.02 +- 0.02 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain

precursor_groups_44961 1544.36 +- 534.84 3 0 3 3 0.01 +- 0.01 3 9

PF12730 (3/3) ABC-2 family transporter protein
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF00465 (2/3) Iron-containing alcohol dehydrogenase
PF00296 (2/3) Luciferase-like monooxygenase
PF00202 (2/3) Aminotransferase class-III

precursor_groups_21578 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family

precursor_groups_45163 14.51 +- 0.00 2 0 0 0 0.21 +- 0.10 2 6

TIGR00342 (2/2) tRNA sulfurtransferase ThiI
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02926 (2/2) THUMP domain
PF02568 (2/2) Thiamine biosynthesis protein (ThiI)
PF00037 (2/2) 4Fe-4S binding domain

precursor_groups_29585 1343.28 +- 978.72 2 0 0 0 0.02 +- 0.02 2 13

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF12846 (2/2) AAA-like domain
PF12642 (2/2) Conjugative transposon protein TcpC
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00877 (2/2) NlpC/P60 family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF13560 (1/2) Helix-turn-helix domain
PF13406 (1/2) Transglycosylase SLT domain
PF00691 (1/2) OmpA family

precursor_groups_817 26.89 +- 5.88 7 0 0 0 0.16 +- 0.20 7 5

PF13561 (7/7) Enoyl-(Acyl carrier protein) reductase
PF08044 (7/7) Domain of unknown function (DUF1707)
PF07690 (7/7) Major Facilitator Superfamily
PF00440 (7/7) Bacterial regulatory proteins, tetR family
PF00067 (7/7) Cytochrome P450

precursor_groups_15041 299.90 +- 133.27 4 0 0 0 0.06 +- 0.10 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_8102 25.12 +- 7.13 2 0 0 0 0.12 +- 0.19 2 6

PF17935 (1/2) Tetracyclin repressor-like, C-terminal domain
PF06751 (1/2) Ethanolamine ammonia lyase large subunit (EutB)
PF05985 (1/2) Ethanolamine ammonia-lyase light chain (EutC)
PF01636 (1/2) Phosphotransferase enzyme family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family

precursor_groups_8453 592.38 +- 294.18 3 0 3 0 0.08 +- 0.22 3 5

PF13649 (3/3) Methyltransferase domain
PF12697 (3/3) Alpha/beta hydrolase family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF01593 (2/3) Flavin containing amine oxidoreductase

precursor_groups_27417 76.51 +- 41.30 4 0 4 0 0.05 +- 0.06 4 7

PF12728 (4/4) Helix-turn-helix domain
PF07995 (4/4) Glucose / Sorbosone dehydrogenase
PF06283 (4/4) Trehalose utilisation
PF03422 (4/4) Carbohydrate binding module (family 6)
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00801 (4/4) PKD domain
PF00589 (4/4) Phage integrase family

precursor_groups_20192 109.46 +- 5.44 5 0 0 0 0.12 +- 0.30 5 11

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00838 (5/5) argininosuccinate lyase
PF14698 (5/5) Argininosuccinate lyase C-terminal
PF03972 (5/5) MmgE/PrpD family
PF02826 (5/5) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01522 (5/5) Polysaccharide deacetylase
PF00596 (5/5) Class II Aldolase and Adducin N-terminal domain
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00206 (5/5) Lyase
PF00005 (5/5) ABC transporter

precursor_groups_37713 306.94 +- 18.06 2 0 2 0 0.01 +- 0.01 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_15049 1387.76 +- 1182.51 7 0 2 0 0.02 +- 0.02 7 12

PF13535 (7/7) ATP-grasp domain
TIGR01263 (6/7) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (6/7) L-amino acid ligase C-terminal domain 2
PF14696 (6/7) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF05721 (6/7) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (6/7) Prephenate dehydrogenase
PF01613 (6/7) Flavin reductase like domain
PF01070 (6/7) FMN-dependent dehydrogenase
PF00903 (6/7) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (6/7) Luciferase-like monooxygenase
PF00155 (6/7) Aminotransferase class I and II
PF18130 (5/7) ATP-grasp N-terminal domain

precursor_groups_14066 854.07 +- 451.42 3 0 0 0 0.01 +- 0.00 3 4

PF00082 (3/3) Subtilase family
TIGR03930 (2/3) WXG100 family type VII secretion target
TIGR03921 (2/3) type VII secretion-associated serine protease mycosin
PF06013 (2/3) Proteins of 100 residues with WXG

precursor_groups_51305 16.08 +- 2.16 2 0 0 0 0.22 +- 0.37 2 6

TIGR02605 (2/2) putative regulatory protein, FmdB family
TIGR01694 (2/2) methylthioadenosine phosphorylase
PF09723 (2/2) Zinc ribbon domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01048 (2/2) Phosphorylase superfamily
PF07690 (1/2) Major Facilitator Superfamily

precursor_groups_21973 625.39 +- 132.43 5 0 0 0 0.01 +- 0.01 5 6

TIGR03930 (5/5) WXG100 family type VII secretion target
TIGR03921 (5/5) type VII secretion-associated serine protease mycosin
TIGR03919 (5/5) type VII secretion protein EccB
PF06013 (5/5) Proteins of 100 residues with WXG
PF05108 (5/5) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/5) Subtilase family

precursor_groups_53944 42.38 +- 0.62 2 0 0 0 0.09 +- 0.25 2 4

PF16945 (2/2) Putative lactococcus lactis phage r1t holin
PF08924 (2/2) Domain of unknown function (DUF1906)
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain

precursor_groups_3826 574.71 +- 631.09 10 0 10 0 0.12 +- 0.25 10 16

TIGR01733 (10/10) amino acid adenylation domain
TIGR01720 (10/10) non-ribosomal peptide synthase domain TIGR01720
TIGR01263 (10/10) 4-hydroxyphenylpyruvate dioxygenase
PF14696 (10/10) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF03621 (10/10) MbtH-like protein
PF02668 (10/10) Taurine catabolism dioxygenase TauD, TfdA family
PF02274 (10/10) Amidinotransferase
PF01070 (10/10) FMN-dependent dehydrogenase
PF00975 (10/10) Thioesterase domain
PF00903 (10/10) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (10/10) Condensation domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00501 (10/10) AMP-binding enzyme
PF00155 (10/10) Aminotransferase class I and II
PF07690 (8/10) Major Facilitator Superfamily

precursor_groups_58221 645.32 +- 489.88 2 0 0 0 0.07 +- 0.21 2 11

TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF02630 (2/2) SCO1/SenC
PF01545 (2/2) Cation efflux family
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase

precursor_groups_36155 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain

precursor_groups_7062 54.96 +- 12.82 3 0 2 0 0.21 +- 0.26 3 11

PF07883 (3/3) Cupin domain
TIGR01409 (2/3) Tat (twin-arginine translocation) pathway signal sequence
PF13478 (2/3) XdhC Rossmann domain
PF03450 (2/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02627 (2/3) Carboxymuconolactone decarboxylase family
PF02625 (2/3) XdhC and CoxI family
PF01799 (2/3) [2Fe-2S] binding domain
PF01315 (2/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_72354 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme

precursor_groups_10969 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_51037 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_62063 210.26 +- 3.86 2 0 0 0 0.04 +- 0.06 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family

precursor_groups_17587 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_groups_81851 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 8

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (2/2) GAF domain
PF12450 (2/2) von Willebrand factor
PF12034 (2/2) Domain of unknown function (DUF3520)
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03704 (2/2) Bacterial transcriptional activator domain
PF00092 (2/2) von Willebrand factor type A domain

precursor_groups_61719 1649.38 +- 170.62 2 0 1 0 0.01 +- 0.00 2 12

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF11706 (2/2) CGNR zinc finger
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF07336 (2/2) Putative stress-induced transcription regulator
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF04854 (2/2) Protein of unknown function, DUF624
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00532 (2/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_82330 225.00 +- 165.00 2 0 0 2 0.03 +- 0.04 2 5

PF13671 (2/2) AAA domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF04055 (2/2) Radical SAM superfamily
PF01928 (2/2) CYTH domain
PF00293 (2/2) NUDIX domain

precursor_groups_14643 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_14647 25.95 +- 12.19 3 0 0 0 0.12 +- 0.07 3 3

PF01266 (3/3) FAD dependent oxidoreductase
PF00753 (3/3) Metallo-beta-lactamase superfamily
PF00355 (3/3) Rieske [2Fe-2S] domain

precursor_groups_21713 270.68 +- 245.32 2 0 2 0 0.08 +- 0.13 2 7

TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_13592 146.12 +- 113.88 2 0 1 0 0.14 +- 0.31 2 13

TIGR02103 (2/2) alpha-1,6-glucosidases, pullulanase-type
PF17967 (2/2) Pullulanase N2 domain
PF11852 (2/2) Domain of unknown function (DUF3372)
PF02922 (2/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (2/2) Alpha amylase, C-terminal all-beta domain
PF00128 (2/2) Alpha amylase, catalytic domain
TIGR01733 (1/2) amino acid adenylation domain
PF13847 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme

precursor_groups_13190 299.34 +- 37.85 3 0 0 0 0.05 +- 0.05 3 12

PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08757 (3/3) CotH kinase protein
PF04138 (3/3) GtrA-like protein
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00672 (3/3) HAMP domain
PF00535 (3/3) Glycosyl transferase family 2
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain
PF16316 (2/3) Domain of unknown function (DUF4956)
PF09359 (2/3) VTC domain

precursor_groups_20284 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family

precursor_groups_63449 48.63 +- 6.77 2 0 0 0 0.19 +- 0.34 2 13

PF13641 (2/2) Glycosyltransferase like family 2
PF12806 (2/2) Acetyl-CoA dehydrogenase C-terminal like
PF12704 (2/2) MacB-like periplasmic core domain
PF12418 (2/2) Acyl-CoA dehydrogenase N terminal
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02687 (2/2) FtsX-like permease family
PF02127 (2/2) Aminopeptidase I zinc metalloprotease (M18)
PF00775 (2/2) Dioxygenase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2

precursor_groups_70693 140.75 +- 119.25 2 0 0 0 0.05 +- 0.06 2 3

PF02018 (2/2) Carbohydrate binding domain
PF01872 (2/2) RibD C-terminal domain
PF00041 (2/2) Fibronectin type III domain

precursor_groups_85535 174.75 +- 18.75 2 0 0 0 0.01 +- 0.01 2 2

PF09335 (2/2) SNARE associated Golgi protein
PF08241 (2/2) Methyltransferase domain

precursor_groups_9673 88.97 +- 4.84 2 0 2 0 0.04 +- 0.05 2 6

PF13517 (2/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF08021 (2/2) Siderophore-interacting FAD-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04954 (2/2) Siderophore-interacting protein
PF01839 (2/2) FG-GAP repeat

precursor_groups_82334 720.96 +- 53.62 2 0 0 0 0.02 +- 0.00 2 11

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF13407 (2/2) Periplasmic binding protein domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01636 (2/2) Phosphotransferase enzyme family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01425 (2/2) Amidase
PF00202 (2/2) Aminotransferase class-III
PF00005 (2/2) ABC transporter
TIGR02713 (1/2) allophanate hydrolase
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF00455 (1/2) DeoR C terminal sensor domain

precursor_groups_373 63.68 +- 48.69 16 0 6 16 0.07 +- 0.12 16 2

PF04055 (16/16) Radical SAM superfamily
PF00583 (16/16) Acetyltransferase (GNAT) family

precursor_groups_20288 42.01 +- 6.74 2 0 0 0 0.10 +- 0.15 2 12

PF12682 (2/2) Flavodoxin
PF00175 (2/2) Oxidoreductase NAD-binding domain
TIGR01234 (1/2) ribulokinase
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13377 (1/2) Periplasmic binding protein-like domain
PF08022 (1/2) FAD-binding domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02424 (1/2) ApbE family
PF00970 (1/2) Oxidoreductase FAD-binding domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00248 (1/2) Aldo/keto reductase family

precursor_groups_1193 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like

precursor_groups_1192 94.31 +- 11.27 2 0 0 0 0.11 +- 0.22 2 26

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
TIGR02378 (2/2) nitrite reductase [NAD(P)H], small subunit
TIGR02374 (2/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (2/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (2/2) Rieske-like [2Fe-2S] domain
PF13520 (2/2) Amino acid permease
PF12840 (2/2) Helix-turn-helix domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11308 (2/2) Glycosyl hydrolases related to GH101 family, GH129
PF08327 (2/2) Activator of Hsp90 ATPase homolog 1-like protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07398 (2/2) MDMPI C-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF03460 (2/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (2/2) Nitrite and sulphite reductase 4Fe-4S domain
PF00106 (2/2) short chain dehydrogenase
PF16640 (1/2) Bacterial Ig-like domain (group 3)
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07098 (1/2) Protein of unknown function (DUF1360)
PF06271 (1/2) RDD family
PF05988 (1/2) Bacterial protein of unknown function (DUF899)
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01810 (1/2) LysE type translocator
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_32012 229.35 +- 53.17 4 0 0 0 0.02 +- 0.01 4 6

PF13545 (4/4) Crp-like helix-turn-helix domain
PF08220 (4/4) DeoR-like helix-turn-helix domain
PF07690 (4/4) Major Facilitator Superfamily
PF00455 (4/4) DeoR C terminal sensor domain
PF00359 (4/4) Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PF00027 (4/4) Cyclic nucleotide-binding domain

precursor_groups_70854 105.07 +- 2.91 2 0 1 0 0.16 +- 0.26 2 18

PF13510 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF07729 (2/2) FCD domain
PF05544 (2/2) Proline racemase
PF05195 (2/2) Aminopeptidase P, N-terminal domain
PF04324 (2/2) BFD-like [2Fe-2S] binding domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00557 (2/2) Metallopeptidase family M24
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13808 (1/2) DDE_Tnp_1-associated

precursor_groups_170 309.22 +- 390.64 18 0 2 0 0.07 +- 0.10 18 2

PF13561 (11/18) Enoyl-(Acyl carrier protein) reductase
PF07690 (9/18) Major Facilitator Superfamily

precursor_groups_58160 214.79 +- 47.95 2 0 0 0 0.08 +- 0.07 2 9

TIGR01234 (2/2) ribulokinase
PF13407 (2/2) Periplasmic binding protein domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_177 107.40 +- 82.05 8 0 2 1 0.07 +- 0.11 8 3

TIGR02434 (4/8) precorrin-6A synthase (deacetylating)
PF03745 (4/8) Domain of unknown function (DUF309)
PF00590 (4/8) Tetrapyrrole (Corrin/Porphyrin) Methylases

precursor_groups_13912 20.40 +- 12.10 2 0 0 0 0.15 +- 0.10 2 1

PF05685 (2/2) Putative restriction endonuclease

precursor_groups_79489 36.62 +- 5.24 2 0 0 0 0.20 +- 0.18 2 12

TIGR01234 (2/2) ribulokinase
PF13377 (2/2) Periplasmic binding protein-like domain
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF03473 (2/2) MOSC domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01263 (2/2) Aldose 1-epimerase
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_2568 12.18 +- 4.03 18 0 0 0 0.18 +- 0.05 18 5

TIGR03802 (18/18) aspartate-alanine antiporter
TIGR03801 (18/18) aspartate 4-decarboxylase
PF06826 (18/18) Predicted Permease Membrane Region
PF02080 (18/18) TrkA-C domain
PF00155 (18/18) Aminotransferase class I and II

precursor_groups_21392 1192.54 +- 713.58 5 0 0 0 0.02 +- 0.02 5 6

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF07811 (5/5) TadE-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF01476 (5/5) LysM domain
PF00482 (5/5) Type II secretion system (T2SS), protein F
PF00437 (5/5) Type II/IV secretion system protein

precursor_groups_21393 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain

precursor_groups_5616 337.77 +- 33.50 2 0 2 0 0.21 +- 0.29 2 29

TIGR02246 (2/2) conserved hypothetical protein
TIGR01207 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13649 (2/2) Methyltransferase domain
PF12051 (2/2) Protein of unknown function (DUF3533)
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF10022 (2/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08332 (2/2) Calcium/calmodulin dependent protein kinase II association domain
PF07730 (2/2) Histidine kinase
PF04673 (2/2) Polyketide synthesis cyclase
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00908 (2/2) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00483 (2/2) Nucleotidyl transferase
PF00248 (2/2) Aldo/keto reductase family
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain

precursor_groups_62118 155.26 +- 134.45 2 0 2 0 0.11 +- 0.28 2 15

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF05977 (1/2) Transmembrane secretion effector
PF03621 (1/2) MbtH-like protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family

precursor_groups_46122 52.56 +- 3.75 3 0 0 0 0.08 +- 0.08 3 5

PF13977 (3/3) BetI-type transcriptional repressor, C-terminal
PF10990 (3/3) Protein of unknown function (DUF2809)
PF07681 (3/3) DoxX
PF00561 (3/3) alpha/beta hydrolase fold
PF00440 (3/3) Bacterial regulatory proteins, tetR family

precursor_groups_2562 72.50 +- 7.50 2 0 0 0 0.03 +- 0.03 2 4

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF12840 (2/2) Helix-turn-helix domain
PF07944 (2/2) Beta-L-arabinofuranosidase, GH127
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_1022 20.61 +- 16.38 9 0 0 0 0.20 +- 0.36 9 6

PF12806 (9/9) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (9/9) Acyl-CoA dehydrogenase N terminal
PF02770 (9/9) Acyl-CoA dehydrogenase, middle domain
PF00775 (9/9) Dioxygenase
PF00441 (9/9) Acyl-CoA dehydrogenase, C-terminal domain
PF13641 (8/9) Glycosyltransferase like family 2

precursor_groups_68725 58.29 +- 19.11 2 0 0 2 0.17 +- 0.25 2 5

PF13186 (2/2) Iron-sulfur cluster-binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF01425 (2/2) Amidase
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_197 66.29 +- 60.85 9 0 3 0 0.09 +- 0.13 9 1

PF07690 (5/9) Major Facilitator Superfamily

precursor_groups_195 236.10 +- 302.19 7 0 3 1 0.09 +- 0.18 7

No common domains found

precursor_groups_26091 34.16 +- 4.43 2 0 0 0 0.15 +- 0.15 2 8

PF13796 (2/2) Putative sensor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07730 (2/2) Histidine kinase
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (2/2) SPFH domain / Band 7 family
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain

precursor_groups_192 120.14 +- 113.24 33 0 29 1 0.10 +- 0.19 33 4

PF07690 (33/33) Major Facilitator Superfamily
PF00484 (29/33) Carbonic anhydrase
PF00916 (26/33) Sulfate permease family
PF03756 (25/33) A-factor biosynthesis hotdog domain

precursor_groups_65723 74.02 +- 1.46 2 0 1 0 0.04 +- 0.04 2 5

TIGR04538 (2/2) cytochrome P450, cyclodipeptide synthase-associated
PF13191 (2/2) AAA ATPase domain
PF08592 (2/2) Domain of unknown function (DUF1772)
PF03055 (2/2) Retinal pigment epithelial membrane protein
PF00067 (2/2) Cytochrome P450

precursor_groups_45592 1258.84 +- 54.84 2 0 2 0 0.02 +- 0.05 2 9

TIGR00830 (2/2) PTS system, glucose subfamily, IIA component
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF03123 (2/2) CAT RNA binding domain
PF02378 (2/2) Phosphotransferase system, EIIC
PF00874 (2/2) PRD domain
PF00367 (2/2) phosphotransferase system, EIIB
PF00358 (2/2) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
PF00069 (2/2) Protein kinase domain

precursor_groups_23986 673.65 +- 236.08 4 0 0 0 0.02 +- 0.05 4 16

PF18448 (4/4) Carbohydrate binding domain
PF17851 (4/4) Beta xylosidase C-terminal Concanavalin A-like domain
PF16353 (4/4) Domain of unknown function(DUF4981)
PF14310 (4/4) Fibronectin type III-like domain
PF04616 (4/4) Glycosyl hydrolases family 43
PF03442 (4/4) Carbohydrate binding domain X2
PF03422 (4/4) Carbohydrate binding module (family 6)
PF02929 (4/4) Beta galactosidase small chain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF01120 (4/4) Alpha-L-fucosidase
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00150 (4/4) Cellulase (glycosyl hydrolase family 5)
PF15902 (3/4) Sortilin, neurotensin receptor 3,
PF14200 (3/4) Ricin-type beta-trefoil lectin domain-like

precursor_groups_19605 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_33127 51.16 +- 8.06 3 0 3 0 0.17 +- 0.37 3 16

TIGR01490 (3/3) HAD hydrolase, family IB
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12710 (3/3) haloacid dehalogenase-like hydrolase
PF12680 (3/3) SnoaL-like domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (3/3) Major Facilitator Superfamily
PF03756 (3/3) A-factor biosynthesis hotdog domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01636 (3/3) Phosphotransferase enzyme family
PF01494 (3/3) FAD binding domain
PF01144 (3/3) Coenzyme A transferase
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_46833 727.66 +- 157.71 3 0 3 3 0.02 +- 0.02 3 15

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01733 (3/3) amino acid adenylation domain
TIGR00778 (3/3) alkylhydroperoxidase AhpD family core domain
PF13454 (3/3) FAD-NAD(P)-binding
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02896 (3/3) PEP-utilising enzyme, TIM barrel domain
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (3/3) Pyridoxamine 5'-phosphate oxidase
PF00881 (3/3) Nitroreductase family
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter

precursor_groups_36442 226.51 +- 44.39 2 0 0 0 0.02 +- 0.01 2 8

TIGR03620 (2/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF16884 (2/2) N-terminal domain of oxidoreductase
PF13560 (2/2) Helix-turn-helix domain
PF12680 (2/2) SnoaL-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase

precursor_groups_69032 208.94 +- 79.94 2 0 2 0 0.02 +- 0.04 2 7

TIGR01733 (2/2) amino acid adenylation domain
PF14518 (2/2) Iron-containing redox enzyme
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF04820 (2/2) Tryptophan halogenase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_513 198.12 +- 240.41 43 0 9 43 0.07 +- 0.12 43 10

TIGR03859 (43/43) coenzyme PQQ biosynthesis protein PqqD
TIGR02109 (43/43) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (43/43) Iron-sulfur cluster-binding domain
PF05402 (43/43) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (43/43) Radical SAM superfamily
TIGR02111 (42/43) coenzyme PQQ biosynthesis protein C
PF03070 (42/43) TENA/THI-4/PQQC family
PF12706 (39/43) Beta-lactamase superfamily domain
TIGR02107 (36/43) coenzyme PQQ precursor peptide PqqA
PF07995 (35/43) Glucose / Sorbosone dehydrogenase

precursor_groups_512 251.83 +- 229.06 10 0 1 0 0.04 +- 0.05 10 2

PF08007 (10/10) Cupin superfamily protein
PF00248 (10/10) Aldo/keto reductase family

precursor_groups_32701 120.40 +- 34.40 2 0 0 2 0.02 +- 0.02 2 5

TIGR01536 (2/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (2/2) Glutamine amidotransferase domain
PF03995 (2/2) Peptidase inhibitor family I36
PF00733 (2/2) Asparagine synthase
PF00067 (2/2) Cytochrome P450

precursor_groups_33129 23.98 +- 1.54 3 0 0 0 0.19 +- 0.36 3 9

TIGR00485 (3/3) translation elongation factor Tu
PF13828 (3/3) Domain of unknown function (DUF4190)
PF09913 (3/3) Predicted membrane protein (DUF2142)
PF08044 (3/3) Domain of unknown function (DUF1707)
PF03144 (3/3) Elongation factor Tu domain 2
PF03143 (3/3) Elongation factor Tu C-terminal domain
PF00009 (3/3) Elongation factor Tu GTP binding domain
PF04138 (2/3) GtrA-like protein
PF00535 (2/3) Glycosyl transferase family 2

precursor_groups_4749 302.33 +- 44.33 2 0 0 0 0.01 +- 0.01 2 7

PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13499 (1/2) EF-hand domain pair
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02378 (1/2) Phosphotransferase system, EIIC
PF01828 (1/2) Peptidase A4 family
PF00367 (1/2) phosphotransferase system, EIIB
PF00089 (1/2) Trypsin

precursor_groups_430 310.09 +- 269.71 4 0 0 0 0.03 +- 0.04 4 8

TIGR01525 (2/4) heavy metal translocating P-type ATPase
PF08007 (2/4) Cupin superfamily protein
PF07371 (2/4) Protein of unknown function (DUF1490)
PF01297 (2/4) Zinc-uptake complex component A periplasmic
PF00950 (2/4) ABC 3 transport family
PF00702 (2/4) haloacid dehalogenase-like hydrolase
PF00122 (2/4) E1-E2 ATPase
PF00005 (2/4) ABC transporter

precursor_groups_24508 78.19 +- 0.44 2 0 0 0 0.10 +- 0.24 2 10

PF17668 (2/2) Acetyltransferase (GNAT) domain
PF13589 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13530 (2/2) Sterol carrier protein domain
PF13527 (2/2) Acetyltransferase (GNAT) domain
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF12821 (2/2) Threonine/Serine exporter, ThrE
PF09335 (2/2) SNARE associated Golgi protein
PF06738 (2/2) Putative threonine/serine exporter
PF00877 (2/2) NlpC/P60 family
PF00183 (2/2) Hsp90 protein

precursor_groups_17111 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR01167 (2/2) LPXTG cell wall anchor domain
PF18014 (2/2) Acetyltransferase (GNAT) domain
PF03777 (2/2) ChpA-C
PF00583 (2/2) Acetyltransferase (GNAT) family

precursor_groups_18812 97.37 +- 34.76 4 0 0 0 0.17 +- 0.32 4 10

TIGR03177 (4/4) Flp pilus assembly protein CpaB
PF16976 (4/4) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/4) AAA domain
PF13400 (4/4) Putative Flp pilus-assembly TadE/G-like
PF07811 (4/4) TadE-like protein
PF00691 (4/4) OmpA family
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain

precursor_groups_59785 350.75 +- 107.92 2 0 0 0 0.01 +- 0.01 2 8

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter

precursor_groups_4744 828.38 +- 731.62 2 0 0 0 0.05 +- 0.06 2 17

PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR02100 (1/2) glycogen debranching enzyme GlgX
TIGR01186 (1/2) glycine betaine/L-proline transport ATP binding subunit
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13183 (1/2) 4Fe-4S dicluster domain
PF09339 (1/2) IclR helix-turn-helix domain
PF04069 (1/2) Substrate binding domain of ABC-type glycine betaine transport system
PF02922 (1/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02754 (1/2) Cysteine-rich domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (1/2) Bacterial transcriptional regulator
PF01565 (1/2) FAD binding domain
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00480 (1/2) ROK family
PF00005 (1/2) ABC transporter

precursor_groups_67341 447.87 +- 22.41 2 0 0 0 0.04 +- 0.02 2 16

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_47838 57.63 +- 1.91 2 0 2 0 0.03 +- 0.03 2 2

PF13649 (2/2) Methyltransferase domain
PF00067 (2/2) Cytochrome P450

precursor_groups_2984 86.77 +- 56.59 26 0 0 0 0.03 +- 0.03 26 2

PF01408 (26/26) Oxidoreductase family, NAD-binding Rossmann fold
PF00232 (26/26) Glycosyl hydrolase family 1

precursor_groups_46448 1981.57 +- 860.49 3 0 3 3 0.01 +- 0.02 3 5

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter

precursor_groups_39890 343.01 +- 173.37 3 0 3 0 0.07 +- 0.21 3 17

TIGR03026 (3/3) nucleotide sugar dehydrogenase
PF13578 (3/3) Methyltransferase domain
PF13191 (3/3) AAA ATPase domain
PF05199 (3/3) GMC oxidoreductase
PF03721 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03704 (3/3) Bacterial transcriptional activator domain
PF01266 (3/3) FAD dependent oxidoreductase
PF01061 (3/3) ABC-2 type transporter
PF01041 (3/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (3/3) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00732 (3/3) GMC oxidoreductase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
PF02801 (2/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/3) Acyl transferase domain
PF00109 (2/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/3) ABC transporter

precursor_groups_2989 87.05 +- 60.96 10 0 10 0 0.04 +- 0.04 10 9

PF16197 (10/10) Ketoacyl-synthetase C-terminal extension
PF14765 (10/10) Polyketide synthase dehydratase
PF08659 (10/10) KR domain
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF00698 (10/10) Acyl transferase domain
PF00550 (10/10) Phosphopantetheine attachment site
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00107 (10/10) Zinc-binding dehydrogenase
PF08240 (9/10) Alcohol dehydrogenase GroES-like domain

precursor_groups_84495 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)

precursor_groups_84497 4695.60 +- 0.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12698 (2/2) ABC-2 family transporter protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter

precursor_groups_39710 774.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

TIGR01473 (2/2) protoheme IX farnesyltransferase
TIGR01413 (2/2) Dyp-type peroxidase family
PF07690 (2/2) Major Facilitator Superfamily
PF04261 (2/2) Dyp-type peroxidase family
PF01040 (2/2) UbiA prenyltransferase family

precursor_groups_2742 157.42 +- 93.51 5 0 0 0 0.04 +- 0.08 5 5

PF06628 (5/5) Catalase-related immune-responsive
PF01475 (5/5) Ferric uptake regulator family
PF00248 (5/5) Aldo/keto reductase family
PF00199 (5/5) Catalase
PF08240 (3/5) Alcohol dehydrogenase GroES-like domain

precursor_groups_65610 24.38 +- 8.12 2 0 0 0 0.12 +- 0.08 2 4

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (2/2) Alpha galactosidase A
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF00652 (2/2) Ricin-type beta-trefoil lectin domain

precursor_groups_13130 677.70 +- 428.02 2 0 2 0 0.02 +- 0.05 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_47723 324.11 +- 14.51 2 0 2 0 0.02 +- 0.03 2 16

TIGR01733 (2/2) amino acid adenylation domain
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13610 (2/2) DDE domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04339 (2/2) Peptidogalycan biosysnthesis/recognition
PF02554 (2/2) Carbon starvation protein CstA
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase

precursor_groups_39552 29.47 +- 3.47 2 0 0 0 0.10 +- 0.09 2 4

TIGR01412 (2/2) Tat-translocated enzyme
PF09375 (2/2) Imelysin
PF04261 (2/2) Dyp-type peroxidase family
PF04185 (2/2) Phosphoesterase family

precursor_groups_14797 36.92 +- 14.90 5 0 0 0 0.06 +- 0.08 5 3

PF09586 (5/5) Bacterial membrane protein YfhO
PF04138 (5/5) GtrA-like protein
PF00535 (5/5) Glycosyl transferase family 2

precursor_groups_209 114.93 +- 57.15 4 0 1 0 0.04 +- 0.03 4 3

PF13673 (4/4) Acetyltransferase (GNAT) domain
PF07702 (4/4) UTRA domain
PF00392 (3/4) Bacterial regulatory proteins, gntR family

precursor_groups_208 112.45 +- 160.34 4 0 1 0 0.13 +- 0.23 4 3

PF00355 (2/4) Rieske [2Fe-2S] domain
PF00175 (2/4) Oxidoreductase NAD-binding domain
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_9169 21.79 +- 4.26 5 0 0 0 0.09 +- 0.12 5 3

PF14016 (5/5) Protein of unknown function (DUF4232)
PF10604 (5/5) Polyketide cyclase / dehydrase and lipid transport
PF07859 (5/5) alpha/beta hydrolase fold

precursor_groups_28197 561.74 +- 523.38 2 0 2 0 0.11 +- 0.24 2 17

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08892 (2/2) YqcI/YcgG family
PF03621 (2/2) MbtH-like protein
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF01863 (1/2) Protein of unknown function DUF45

precursor_groups_26 99.36 +- 86.34 150 1 59 3 0.16 +- 0.21 149 6

PF00005 (89/150) ABC transporter
PF03412 (87/150) Peptidase C39 family
PF00664 (87/150) ABC transporter transmembrane region
TIGR03796 (86/150) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03797 (85/150) NHLM bacteriocin system ABC transporter, ATP-binding protein
PF13437 (81/150) HlyD family secretion protein

precursor_groups_60022 222.57 +- 67.66 2 0 0 0 0.07 +- 0.04 2 12

TIGR01428 (2/2) haloacid dehalogenase, type II
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF04952 (1/2) Succinylglutamate desuccinylase / Aspartoacylase family
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III

precursor_groups_22610 71.51 +- 26.10 5 0 5 5 0.07 +- 0.04 5 2

PF04055 (5/5) Radical SAM superfamily
PF00583 (5/5) Acetyltransferase (GNAT) family

precursor_groups_2188 209.10 +- 104.67 6 0 0 0 0.09 +- 0.18 6 4

PF00171 (5/6) Aldehyde dehydrogenase family
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00067 (3/6) Cytochrome P450
PF00005 (3/6) ABC transporter

precursor_groups_81042 636.32 +- 221.68 2 0 0 0 0.02 +- 0.03 2 3

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily

precursor_groups_55307 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V

precursor_groups_47051 284.94 +- 150.47 3 0 3 0 0.04 +- 0.04 3 11

TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
TIGR00414 (3/3) serine--tRNA ligase
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03972 (3/3) MmgE/PrpD family
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00587 (3/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00550 (3/3) Phosphopantetheine attachment site
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family

precursor_groups_67751 81.99 +- 26.34 2 0 2 0 0.14 +- 0.19 2 8

PF06889 (2/2) Protein of unknown function (DUF1266)
PF03795 (2/2) YCII-related domain
PF00248 (2/2) Aldo/keto reductase family
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00005 (1/2) ABC transporter

precursor_groups_2182 238.88 +- 175.64 2 0 0 0 0.13 +- 0.27 2 21

TIGR03925 (2/2) type VII secretion protein EccCb
TIGR03924 (2/2) type VII secretion protein EccCa
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF08241 (2/2) Methyltransferase domain
PF07811 (2/2) TadE-like protein
PF01638 (2/2) HxlR-like helix-turn-helix
PF01580 (2/2) FtsK/SpoIIIE family
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03696 (1/2) RHS repeat-associated core domain
PF15575 (1/2) Immunity protein 49
PF13614 (1/2) AAA domain
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF10609 (1/2) NUBPL iron-transfer P-loop NTPase
PF03534 (1/2) Salmonella virulence plasmid 65kDa B protein
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00583 (1/2) Acetyltransferase (GNAT) family

precursor_groups_56078 58.18 +- 2.13 2 0 0 0 0.15 +- 0.08 2 8

PF07969 (2/2) Amidohydrolase family
PF07729 (2/2) FCD domain
PF07690 (2/2) Major Facilitator Superfamily
PF05988 (2/2) Bacterial protein of unknown function (DUF899)
PF01979 (2/2) Amidohydrolase family
PF01047 (2/2) MarR family
PF00582 (2/2) Universal stress protein family
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_35360 1161.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF17912 (2/2) MalK OB fold domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF12899 (2/2) Alkaline and neutral invertase
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_24878 33.15 +- 2.48 3 0 0 0 0.12 +- 0.07 3 7

TIGR03211 (3/3) catechol 2,3 dioxygenase
PF07729 (3/3) FCD domain
PF07690 (3/3) Major Facilitator Superfamily
PF04303 (3/3) PrpF protein
PF03737 (3/3) Aldolase/RraA
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00392 (3/3) Bacterial regulatory proteins, gntR family

precursor_groups_18822 307.75 +- 125.21 4 0 0 0 0.01 +- 0.00 4 2

PF00089 (4/4) Trypsin
PF13517 (3/4) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

precursor_groups_56564 80.99 +- 2.04 2 0 2 0 0.20 +- 0.32 2 8

TIGR01534 (2/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF09362 (2/2) Domain of unknown function (DUF1996)
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05231 (2/2) MASE1
PF02800 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF01757 (2/2) Acyltransferase family
PF00781 (2/2) Diacylglycerol kinase catalytic domain
PF00044 (2/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_72901 86.33 +- 0.33 2 0 0 0 0.02 +- 0.02 2 2

PF07683 (2/2) Cobalamin synthesis protein cobW C-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family

precursor_groups_77624 147.49 +- 19.43 2 0 0 2 0.17 +- 0.22 2 20

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01255 (2/2) formate acetyltransferase
TIGR00886 (2/2) nitrite transporter
PF13247 (2/2) 4Fe-4S dicluster domain
PF07690 (2/2) Major Facilitator Superfamily
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01228 (2/2) Glycine radical
PF00384 (2/2) Molybdopterin oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00037 (2/2) 4Fe-4S binding domain
TIGR02374 (1/2) nitrite reductase [NAD(P)H], large subunit
PF18267 (1/2) Rubredoxin NAD+ reductase C-terminal domain
PF13806 (1/2) Rieske-like [2Fe-2S] domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF03460 (1/2) Nitrite/Sulfite reductase ferredoxin-like half domain
PF01077 (1/2) Nitrite and sulphite reductase 4Fe-4S domain

precursor_groups_45811 187.64 +- 18.76 2 0 0 0 0.05 +- 0.04 2 8

PF14016 (2/2) Protein of unknown function (DUF4232)
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF09261 (2/2) Alpha mannosidase middle domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_25675 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase

precursor_groups_21705 611.83 +- 229.98 5 0 0 0 0.01 +- 0.01 5 11

TIGR01490 (5/5) HAD hydrolase, family IB
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF00753 (5/5) Metallo-beta-lactamase superfamily
PF00501 (5/5) AMP-binding enzyme
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF05655 (4/5) Pseudomonas avirulence D protein (AvrD)
PF01648 (4/5) 4'-phosphopantetheinyl transferase superfamily
PF00975 (4/5) Thioesterase domain
PF00550 (4/5) Phosphopantetheine attachment site

precursor_groups_28285 416.77 +- 0.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07876 (2/2) Stress responsive A/B Barrel Domain
PF04909 (2/2) Amidohydrolase
PF00501 (2/2) AMP-binding enzyme

precursor_groups_16774 192.40 +- 85.37 6 0 0 0 0.02 +- 0.03 6 7

TIGR03930 (6/6) WXG100 family type VII secretion target
TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF06013 (6/6) Proteins of 100 residues with WXG
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (3/6) YbaB/EbfC DNA-binding family

precursor_groups_2343 222.48 +- 53.07 3 0 0 0 0.01 +- 0.01 3 3

PF04134 (3/3) Protein of unknown function, DUF393
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13560 (2/3) Helix-turn-helix domain

precursor_groups_25479 31.27 +- 6.97 2 0 2 0 0.13 +- 0.25 2 8

PF17871 (2/2) AAA lid domain
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF07690 (2/2) Major Facilitator Superfamily
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF01546 (2/2) Peptidase family M20/M25/M40
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_24472 774.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 2

PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00069 (2/2) Protein kinase domain

precursor_groups_15997 23.17 +- 6.67 3 0 3 0 0.10 +- 0.11 3 7

PF13407 (3/3) Periplasmic binding protein domain
PF08376 (3/3) Nitrate and nitrite sensing
PF05331 (3/3) Protein of unknown function (DUF742)
PF03259 (3/3) Roadblock/LC7 domain
PF03029 (3/3) Conserved hypothetical ATP binding protein
PF00672 (3/3) HAMP domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

precursor_groups_71489 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family

precursor_groups_1378 451.50 +- 64.50 2 0 2 0 0.01 +- 0.00 2 3

TIGR03930 (2/2) WXG100 family type VII secretion target
PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG

precursor_groups_31656 201.84 +- 49.19 3 0 0 0 0.12 +- 0.20 3 23

TIGR04037 (3/3) LLM-partnered FMN reductase, CE1759 family
TIGR04036 (3/3) putative luciferase-like monooxygenase, FMN-dependent, CE1758 family
PF17853 (3/3) GGDEF-like domain
PF14542 (3/3) GCN5-related N-acetyl-transferase
PF14525 (3/3) AraC-binding-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF13191 (3/3) AAA ATPase domain
PF12833 (3/3) Helix-turn-helix domain
PF12697 (3/3) Alpha/beta hydrolase family
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07969 (3/3) Amidohydrolase family
PF07859 (3/3) alpha/beta hydrolase fold
PF07681 (3/3) DoxX
PF03358 (3/3) NADPH-dependent FMN reductase
PF02852 (3/3) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF01184 (3/3) GPR1/FUN34/yaaH family
PF00857 (3/3) Isochorismatase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00210 (3/3) Ferritin-like domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_86564 185.29 +- 74.71 2 0 2 0 0.01 +- 0.01 2 3

PF02195 (2/2) ParB-like nuclease domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase

precursor_groups_11429 63.39 +- 17.86 2 0 0 0 0.04 +- 0.02 2 5

PF13404 (2/2) AsnC-type helix-turn-helix domain
PF01037 (2/2) Lrp/AsnC ligand binding domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle

precursor_groups_55789 150.11 +- 37.53 2 0 0 0 0.06 +- 0.05 2 6

PF11127 (2/2) Protein of unknown function (DUF2892)
PF02583 (2/2) Metal-sensitive transcriptional repressor
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00581 (2/2) Rhodanese-like domain
PF00313 (2/2) 'Cold-shock' DNA-binding domain

precursor_groups_19395 208.21 +- 217.64 3 0 0 0 0.05 +- 0.06 3 4

PF13439 (3/3) Glycosyltransferase Family 4
PF06737 (3/3) Transglycosylase-like domain
PF01476 (3/3) LysM domain
PF00534 (3/3) Glycosyl transferases group 1

precursor_groups_58968 137.33 +- 82.04 2 0 2 0 0.04 +- 0.05 2 12

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF03936 (2/2) Terpene synthase family, metal binding domain
PF00348 (2/2) Polyprenyl synthetase
PF00067 (2/2) Cytochrome P450
TIGR01534 (1/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02800 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00106 (1/2) short chain dehydrogenase
PF00044 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_39856 89.33 +- 31.49 3 0 0 0 0.19 +- 0.32 3 10

PF18844 (3/3) Bacterial archaeo-eukaryotic release factor family 2
PF13847 (3/3) Methyltransferase domain
PF13377 (3/3) Periplasmic binding protein-like domain
PF11387 (3/3) Protein of unknown function (DUF2795)
PF08244 (3/3) Glycosyl hydrolases family 32 C terminal
PF01569 (3/3) PAP2 superfamily
PF00781 (3/3) Diacylglycerol kinase catalytic domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00356 (3/3) Bacterial regulatory proteins, lacI family
PF00251 (3/3) Glycosyl hydrolases family 32 N-terminal domain

precursor_groups_28971 216.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 2

PF06013 (2/2) Proteins of 100 residues with WXG
PF02254 (2/2) TrkA-N domain

precursor_groups_17856 17.54 +- 8.83 4 0 4 0 0.18 +- 0.25 4 14

PF12740 (4/4) Chlorophyllase enzyme
PF12697 (4/4) Alpha/beta hydrolase family
PF06386 (4/4) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (4/4) Gas vesicle synthesis protein GvpO
PF05121 (4/4) Gas vesicle protein K
PF05120 (4/4) Gas vesicle protein G
PF00741 (4/4) Gas vesicle protein
PF00561 (4/4) alpha/beta hydrolase fold
TIGR03086 (2/4) TIGR03086 family protein
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF11716 (2/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF11611 (2/4) Domain of unknown function (DUF4352)
PF07690 (2/4) Major Facilitator Superfamily
PF00730 (2/4) HhH-GPD superfamily base excision DNA repair protein

precursor_groups_73414 199.03 +- 100.12 2 0 0 0 0.17 +- 0.30 2 18

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF13518 (1/2) Helix-turn-helix domain
PF13401 (1/2) AAA domain
PF09299 (1/2) Mu transposase, C-terminal
PF08722 (1/2) TnsA endonuclease N terminal
PF06527 (1/2) TniQ
PF00665 (1/2) Integrase core domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_38284 154.57 +- 48.14 2 0 2 0 0.08 +- 0.18 2 15

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05995 (2/2) Cysteine dioxygenase type I
PF03621 (2/2) MbtH-like protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00975 (2/2) Thioesterase domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_74379 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_25018 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450

precursor_groups_38447 20.19 +- 4.93 3 0 0 0 0.17 +- 0.34 3 8

TIGR00762 (3/3) EDD domain protein, DegV family
TIGR00360 (3/3) ComEC/Rec2-related protein
PF12840 (3/3) Helix-turn-helix domain
PF07690 (3/3) Major Facilitator Superfamily
PF03772 (3/3) Competence protein
PF02645 (3/3) Uncharacterised protein, DegV family COG1307
PF00797 (3/3) N-acetyltransferase
PF00753 (3/3) Metallo-beta-lactamase superfamily

precursor_groups_45055 337.28 +- 59.65 2 0 1 0 0.06 +- 0.08 2 9

PF07690 (2/2) Major Facilitator Superfamily
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
TIGR03544 (1/2) DivIVA domain
TIGR01297 (1/2) cation diffusion facilitator family transporter
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF05103 (1/2) DivIVA protein
PF04234 (1/2) CopC domain
PF01545 (1/2) Cation efflux family
PF00581 (1/2) Rhodanese-like domain

precursor_groups_6246 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter

precursor_groups_12835 185.41 +- 246.26 7 0 0 0 0.04 +- 0.05 7 2

TIGR03930 (7/7) WXG100 family type VII secretion target
PF06013 (7/7) Proteins of 100 residues with WXG

precursor_groups_690 3950.85 +- 3927.37 2 0 1 1 0.05 +- 0.19 2 22

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02116 (1/2) addiction module toxin, Txe/YoeB family
TIGR01552 (1/2) prevent-host-death family protein
PF18478 (1/2) PIN like domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF12419 (1/2) SNF2 Helicase protein
PF07969 (1/2) Amidohydrolase family
PF06769 (1/2) YoeB-like toxin of bacterial type II toxin-antitoxin system
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04434 (1/2) SWIM zinc finger
PF04255 (1/2) Protein of unknown function (DUF433)
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02604 (1/2) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01966 (1/2) HD domain
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00271 (1/2) Helicase conserved C-terminal domain
PF00176 (1/2) SNF2 family N-terminal domain
PF00005 (1/2) ABC transporter

precursor_groups_7765 1072.50 +- 214.50 2 0 2 0 0.01 +- 0.01 2 11

PF16861 (2/2) Carbamoyltransferase C-terminus
PF13560 (2/2) Helix-turn-helix domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_2334 256.55 +- 218.63 33 0 0 0 0.03 +- 0.03 33 10

TIGR03930 (33/33) WXG100 family type VII secretion target
TIGR03919 (33/33) type VII secretion protein EccB
PF06013 (33/33) Proteins of 100 residues with WXG
PF05108 (33/33) Type VII secretion system ESX-1, transport TM domain B
TIGR03920 (32/33) type VII secretion integral membrane protein EccD
PF08817 (31/33) WXG100 protein secretion system (Wss), protein YukD
PF02575 (31/33) YbaB/EbfC DNA-binding family
PF15644 (23/33) Papain fold toxin 1, glutamine deamidase
PF07179 (22/33) SseB protein N-terminal domain
PF00652 (22/33) Ricin-type beta-trefoil lectin domain

precursor_groups_55899 55.24 +- 28.63 2 0 0 0 0.12 +- 0.21 2 11

PF09861 (2/2) Lactate racemase N-terminal domain
PF07729 (2/2) FCD domain
PF04909 (2/2) Amidohydrolase
PF01969 (2/2) Protein of unknown function DUF111
PF00731 (2/2) AIR carboxylase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00248 (2/2) Aldo/keto reductase family
TIGR00299 (1/2) TIGR00299 family protein
TIGR00268 (1/2) TIGR00268 family protein
PF02540 (1/2) NAD synthase
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family

precursor_groups_67622 62.30 +- 4.94 2 0 0 0 0.15 +- 0.15 2 4

PF07690 (2/2) Major Facilitator Superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle

precursor_groups_68106 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 10

TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
PF13489 (2/2) Methyltransferase domain
PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13238 (2/2) AAA domain
PF04055 (2/2) Radical SAM superfamily
PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_60110 36.01 +- 8.86 2 0 2 0 0.06 +- 0.08 2 3

PF14019 (2/2) Protein of unknown function (DUF4235)
PF12277 (2/2) Protein of unknown function (DUF3618)
PF07332 (2/2) Putative Actinobacterial Holin-X, holin superfamily III

precursor_groups_16236 47.65 +- 40.64 6 0 4 0 0.15 +- 0.29 6 13

PF13977 (6/6) BetI-type transcriptional repressor, C-terminal
PF13607 (6/6) Succinyl-CoA ligase like flavodoxin domain
PF13549 (6/6) ATP-grasp domain
PF13459 (6/6) 4Fe-4S single cluster domain
PF13380 (6/6) CoA binding domain
PF10589 (6/6) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF02771 (6/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (6/6) Acyl-CoA dehydrogenase, middle domain
PF02737 (6/6) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01512 (6/6) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00725 (6/6) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00441 (6/6) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family

precursor_groups_36166 422.22 +- 203.82 3 0 3 0 0.03 +- 0.03 3 8

PF16861 (3/3) Carbamoyltransferase C-terminus
PF13350 (3/3) Tyrosine phosphatase family
PF02543 (3/3) Carbamoyltransferase N-terminus
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00005 (3/3) ABC transporter

precursor_groups_6887 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 2

PF04464 (2/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF00535 (2/2) Glycosyl transferase family 2

precursor_groups_6888 171.70 +- 129.89 6 0 0 0 0.07 +- 0.15 6 3

PF08445 (6/6) FR47-like protein
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00005 (3/6) ABC transporter

precursor_groups_83681 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase

precursor_groups_67381 304.77 +- 44.77 2 0 0 0 0.02 +- 0.01 2 6

PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01935 (2/2) Helicase HerA, central domain
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain

precursor_groups_34387 259.33 +- 0.94 3 0 0 0 0.01 +- 0.00 3 3

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00999 (3/3) Sodium/hydrogen exchanger family
PF00550 (3/3) Phosphopantetheine attachment site

precursor_groups_74203 256.74 +- 18.38 2 0 0 0 0.11 +- 0.10 2 16

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF18050 (2/2) Cyclophilin-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13478 (2/2) XdhC Rossmann domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_55256 109.67 +- 50.19 2 0 0 0 0.12 +- 0.15 2 16

PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (1/2) FCD domain
PF04909 (1/2) Amidohydrolase
PF01081 (1/2) KDPG and KHG aldolase
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00248 (1/2) Aldo/keto reductase family

precursor_groups_12066 1002.86 +- 0.00 2 0 2 0 0.02 +- 0.01 2 11

TIGR01840 (2/2) esterase, PHB depolymerase family
PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF10503 (2/2) Esterase PHB depolymerase
PF03466 (2/2) LysR substrate binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00664 (2/2) ABC transporter transmembrane region
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter

precursor_groups_6405 17.34 +- 2.16 2 0 0 0 0.16 +- 0.13 2 4

TIGR00778 (2/2) alkylhydroperoxidase AhpD family core domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF08282 (1/2) haloacid dehalogenase-like hydrolase

precursor_groups_54415 183.95 +- 117.50 2 0 0 0 0.09 +- 0.21 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13515 (2/2) Fusaric acid resistance protein-like
PF13454 (2/2) FAD-NAD(P)-binding
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF10282 (2/2) Lactonase, 7-bladed beta-propeller
PF07690 (2/2) Major Facilitator Superfamily
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00206 (2/2) Lyase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_54414 480.00 +- 0.00 2 0 2 0 0.03 +- 0.00 2 6

TIGR00924 (2/2) amino acid/peptide transporter (Peptide:H+ symporter)
PF16864 (2/2) Dimerisation domain
PF04820 (2/2) Tryptophan halogenase
PF00891 (2/2) O-methyltransferase domain
PF00854 (2/2) POT family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_3163 245.26 +- 121.26 3 0 0 0 0.07 +- 0.20 3 3

PF02782 (2/3) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/3) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/3) Histidine phosphatase superfamily (branch 1)

precursor_groups_12733 114.15 +- 7.92 2 0 2 0 0.10 +- 0.09 2 16

TIGR01662 (2/2) HAD hydrolase, family IIIA
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13580 (2/2) SIS domain
PF13439 (2/2) Glycosyltransferase Family 4
PF13242 (2/2) HAD-hyrolase-like
PF12028 (2/2) Protein of unknown function (DUF3515)
PF04230 (2/2) Polysaccharide pyruvyl transferase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF01467 (2/2) Cytidylyltransferase-like
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01075 (2/2) Glycosyltransferase family 9 (heptosyltransferase)
PF00535 (2/2) Glycosyl transferase family 2
PF00534 (2/2) Glycosyl transferases group 1
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR02199 (1/2) bifunctional protein RfaE, domain II
TIGR00125 (1/2) cytidyltransferase-like domain

precursor_groups_1870 81.90 +- 63.05 29 0 11 29 0.13 +- 0.16 29 5

TIGR03882 (29/29) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (29/29) thiazole/oxazole-forming peptide maturase, SagD family component
PF03704 (29/29) Bacterial transcriptional activator domain
PF02624 (29/29) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00486 (28/29) Transcriptional regulatory protein, C terminal

precursor_groups_70218 15.80 +- 3.70 2 0 0 0 0.21 +- 0.21 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF04341 (2/2) Protein of unknown function, DUF485
PF04029 (2/2) 2-phosphosulpholactate phosphatase
PF00474 (2/2) Sodium:solute symporter family
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF18029 (1/2) Glyoxalase-like domain

precursor_groups_26113 129.12 +- 80.38 3 0 0 0 0.04 +- 0.05 3 4

PF08223 (3/3) PaaX-like protein C-terminal domain
PF07848 (3/3) PaaX-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF00534 (3/3) Glycosyl transferases group 1

precursor_groups_80587 22.87 +- 1.20 2 0 0 0 0.20 +- 0.17 2 23

TIGR03346 (2/2) ATP-dependent chaperone protein ClpB
TIGR02350 (2/2) chaperone protein DnaK
TIGR01068 (2/2) thioredoxin
PF17871 (2/2) AAA lid domain
PF13591 (2/2) MerR HTH family regulatory protein
PF10431 (2/2) C-terminal, D2-small domain, of ClpB protein
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07724 (2/2) AAA domain (Cdc48 subfamily)
PF02861 (2/2) Clp amino terminal domain, pathogenicity island component
PF02148 (2/2) Zn-finger in ubiquitin-hydrolases and other protein
PF01556 (2/2) DnaJ C terminal domain
PF01025 (2/2) GrpE
PF00226 (2/2) DnaJ domain
PF00085 (2/2) Thioredoxin
PF00027 (2/2) Cyclic nucleotide-binding domain
PF00012 (2/2) Hsp70 protein
PF00004 (2/2) ATPase family associated with various cellular activities (AAA)
TIGR00630 (1/2) excinuclease ABC subunit A
PF17755 (1/2) UvrA DNA-binding domain
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
PF01411 (1/2) tRNA synthetases class II (A)
PF00005 (1/2) ABC transporter

precursor_groups_31428 133.50 +- 84.85 3 0 0 0 0.08 +- 0.20 3 4

PF07690 (3/3) Major Facilitator Superfamily
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_7448 764.63 +- 408.17 4 0 4 4 0.04 +- 0.17 4 8

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF13520 (4/4) Amino acid permease
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family

precursor_groups_1878 217.04 +- 228.81 5 0 0 0 0.07 +- 0.15 5 5

PF07690 (5/5) Major Facilitator Superfamily
PF03713 (5/5) Domain of unknown function (DUF305)
PF14342 (3/5) Domain of unknown function (DUF4396)
PF03860 (3/5) Domain of Unknown Function (DUF326)
PF00291 (3/5) Pyridoxal-phosphate dependent enzyme

precursor_groups_61379 554.14 +- 219.86 2 0 2 0 0.02 +- 0.02 2 6

PF16861 (2/2) Carbamoyltransferase C-terminus
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00005 (2/2) ABC transporter

precursor_groups_69347 810.28 +- 423.28 2 0 0 1 0.04 +- 0.15 2 15

PF13814 (2/2) Replication-relaxation
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF03704 (2/2) Bacterial transcriptional activator domain
PF01478 (2/2) Type IV leader peptidase family
PF01476 (2/2) LysM domain
PF00437 (2/2) Type II/IV secretion system protein
TIGR00702 (1/2) YcaO-type kinase domain
PF13649 (1/2) Methyltransferase domain
PF07812 (1/2) TfuA-like protein
PF07479 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01210 (1/2) NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
PF00482 (1/2) Type II secretion system (T2SS), protein F

precursor_groups_63906 236.46 +- 153.54 2 0 2 2 0.02 +- 0.03 2 5

TIGR02438 (2/2) catechol 1,2-dioxygenase
PF04444 (2/2) Catechol dioxygenase N terminus
PF01494 (2/2) FAD binding domain
PF00775 (2/2) Dioxygenase
PF00733 (2/2) Asparagine synthase

precursor_groups_34143 45.54 +- 18.30 3 0 0 0 0.10 +- 0.12 3 7

PF04016 (3/3) Putative heavy-metal chelation
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00288 (3/3) GHMP kinases N terminal domain
PF00005 (3/3) ABC transporter
PF05175 (2/3) Methyltransferase small domain

precursor_groups_46484 994.22 +- 94.22 2 0 0 0 0.02 +- 0.02 2 14

TIGR04416 (2/2) group II intron reverse transcriptase/maturase
PF14759 (2/2) Reductase C-terminal
PF08388 (2/2) Group II intron, maturase-specific domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04213 (2/2) Htaa
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00665 (2/2) Integrase core domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00248 (2/2) Aldo/keto reductase family
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00078 (2/2) Reverse transcriptase (RNA-dependent DNA polymerase)
PF00067 (2/2) Cytochrome P450

precursor_groups_78736 62.24 +- 15.92 2 0 0 0 0.12 +- 0.17 2 7

TIGR00996 (2/2) virulence factor Mce family protein
PF13577 (2/2) SnoaL-like domain
PF13406 (2/2) Transglycosylase SLT domain
PF11887 (2/2) Cholesterol uptake porter CUP1 of Mce4, putative
PF02470 (2/2) MlaD protein
PF02405 (2/2) Permease MlaE
PF00005 (2/2) ABC transporter

precursor_groups_32830 262.22 +- 21.70 3 0 3 3 0.14 +- 0.15 3 18

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01536 (3/3) asparagine synthase (glutamine-hydrolyzing)
TIGR01525 (3/3) heavy metal translocating P-type ATPase
PF13537 (3/3) Glutamine amidotransferase domain
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF06197 (3/3) Protein of unknown function (DUF998)
PF05141 (3/3) Pyoverdine/dityrosine biosynthesis protein
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00733 (3/3) Asparagine synthase
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00067 (3/3) Cytochrome P450
PF00005 (3/3) ABC transporter

precursor_groups_32024 125.03 +- 36.02 3 0 3 0 0.14 +- 0.30 3 21

TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF14765 (2/3) Polyketide synthase dehydratase
PF08990 (2/3) Erythronolide synthase docking
PF08659 (2/3) KR domain
PF08044 (2/3) Domain of unknown function (DUF1707)

precursor_groups_77083 496.76 +- 283.24 2 0 2 0 0.02 +- 0.01 2 15

TIGR01803 (2/2) chorismate mutase related enzymes
TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (2/2) aminodeoxychorismate synthase, component I
PF18456 (2/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF04715 (2/2) Anthranilate synthase component I, N terminal region
PF02153 (2/2) Prephenate dehydrogenase
PF01817 (2/2) Chorismate mutase type II
PF01474 (2/2) Class-II DAHP synthetase family
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I

precursor_groups_69987 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_59887 70.34 +- 2.22 2 0 0 0 0.23 +- 0.10 2 4

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein

precursor_groups_26733 37.78 +- 1.22 2 0 0 0 0.08 +- 0.06 2 4

PF17851 (2/2) Beta xylosidase C-terminal Concanavalin A-like domain
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF04616 (2/2) Glycosyl hydrolases family 43
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_66214 144.28 +- 34.15 2 0 0 0 0.07 +- 0.08 2 8

PF13377 (2/2) Periplasmic binding protein-like domain
PF08244 (2/2) Glycosyl hydrolases family 32 C terminal
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00251 (2/2) Glycosyl hydrolases family 32 N-terminal domain

precursor_groups_35120 653.79 +- 174.26 3 0 0 0 0.01 +- 0.00 3 9

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13535 (3/3) ATP-grasp domain
PF13378 (3/3) Enolase C-terminal domain-like
PF12146 (3/3) Serine aminopeptidase, S33
PF03795 (3/3) YCII-related domain
PF03321 (3/3) GH3 auxin-responsive promoter
PF01613 (3/3) Flavin reductase like domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II

precursor_groups_6662 147.87 +- 24.54 4 0 0 0 0.03 +- 0.04 4 10

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR00843 (4/4) benzoate transporter
PF17920 (4/4) Tetracyclin repressor-like, C-terminal domain
PF13454 (4/4) FAD-NAD(P)-binding
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme

precursor_groups_26609 98.56 +- 110.67 4 0 0 0 0.14 +- 0.30 4 8

PF13183 (4/4) 4Fe-4S dicluster domain
PF02913 (4/4) FAD linked oxidases, C-terminal domain
PF02518 (4/4) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01565 (4/4) FAD binding domain
PF00672 (4/4) HAMP domain
PF00512 (4/4) His Kinase A (phospho-acceptor) domain
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00072 (4/4) Response regulator receiver domain

precursor_groups_6666 29.99 +- 4.41 4 0 0 0 0.16 +- 0.32 4 10

PF17042 (4/4) Nucleotide-binding C-terminal domain
PF07729 (4/4) FCD domain
PF07005 (4/4) Sugar-binding N-terminal domain
PF01261 (4/4) Xylose isomerase-like TIM barrel
PF00596 (4/4) Class II Aldolase and Adducin N-terminal domain
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
TIGR01935 (3/4) RraA family
PF04332 (3/4) Protein of unknown function (DUF475)
PF03737 (3/4) Aldolase/RraA

precursor_groups_11194 227.50 +- 32.50 2 0 2 0 0.01 +- 0.00 2 2

PF10824 (2/2) Excreted virulence factor EspC, type VII ESX diderm
PF06013 (2/2) Proteins of 100 residues with WXG

precursor_groups_6668 89.38 +- 40.62 2 0 0 0 0.03 +- 0.01 2 4

PF13466 (2/2) STAS domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02607 (2/2) B12 binding domain
PF02310 (2/2) B12 binding domain

precursor_groups_12881 73.89 +- 8.30 2 0 0 0 0.12 +- 0.25 2 10

PF07811 (2/2) TadE-like protein
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
TIGR03177 (1/2) Flp pilus assembly protein CpaB
PF16976 (1/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (1/2) AAA domain
PF08241 (1/2) Methyltransferase domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF00005 (1/2) ABC transporter

precursor_groups_12882 304.96 +- 212.94 8 0 0 0 0.04 +- 0.04 8 8

TIGR01821 (8/8) 5-aminolevulinic acid synthase
PF07690 (8/8) Major Facilitator Superfamily
PF06224 (8/8) Winged helix DNA-binding domain
PF03466 (8/8) LysR substrate binding domain
PF01408 (8/8) Oxidoreductase family, NAD-binding Rossmann fold
PF00583 (8/8) Acetyltransferase (GNAT) family
PF00155 (8/8) Aminotransferase class I and II
PF00126 (8/8) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_29959 1134.75 +- 490.59 4 0 0 0 0.01 +- 0.01 4 9

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF04686 (4/4) Streptomyces sporulation and cell division protein, SsgA
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase

precursor_groups_69507 324.00 +- 66.00 2 0 0 0 0.01 +- 0.00 2 3

PF02784 (2/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00491 (2/2) Arginase family
PF01636 (1/2) Phosphotransferase enzyme family

precursor_groups_11352 175.15 +- 104.09 7 0 7 0 0.03 +- 0.03 7 8

TIGR01733 (7/7) amino acid adenylation domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF01494 (7/7) FAD binding domain
PF00975 (7/7) Thioesterase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00106 (7/7) short chain dehydrogenase

precursor_groups_4804 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix

precursor_groups_13697 173.68 +- 35.26 5 0 1 0 0.12 +- 0.17 5 19

PF17853 (5/5) GGDEF-like domain
PF14542 (5/5) GCN5-related N-acetyl-transferase
PF14525 (5/5) AraC-binding-like domain
PF13556 (5/5) PucR C-terminal helix-turn-helix domain
PF13191 (5/5) AAA ATPase domain
PF12833 (5/5) Helix-turn-helix domain
PF12697 (5/5) Alpha/beta hydrolase family
PF07969 (5/5) Amidohydrolase family
PF07859 (5/5) alpha/beta hydrolase fold
PF07681 (5/5) DoxX
PF01547 (5/5) Bacterial extracellular solute-binding protein
PF01184 (5/5) GPR1/FUN34/yaaH family
PF00857 (5/5) Isochorismatase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00210 (5/5) Ferritin-like domain
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF07992 (3/5) Pyridine nucleotide-disulphide oxidoreductase
PF02852 (3/5) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

precursor_groups_8732 53.79 +- 13.26 5 0 5 0 0.18 +- 0.19 5 24

TIGR00073 (5/5) hydrogenase accessory protein HypB
TIGR00072 (5/5) hydrogenase maturation protease
PF14720 (5/5) NiFe/NiFeSe hydrogenase small subunit C-terminal
PF14016 (5/5) Protein of unknown function (DUF4232)
PF07503 (5/5) HypF finger
PF02492 (5/5) CobW/HypB/UreG, nucleotide-binding domain
PF01750 (5/5) Hydrogenase maturation protease
PF01300 (5/5) Telomere recombination
PF01155 (5/5) Hydrogenase/urease nickel incorporation, metallochaperone, hypA
PF01058 (5/5) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00708 (5/5) Acylphosphatase
PF00374 (5/5) Nickel-dependent hydrogenase
TIGR00143 (4/5) carbamoyltransferase HypF
PF17788 (4/5) HypF Kae1-like domain
TIGR02124 (3/5) hydrogenase expression/formation protein HypE
TIGR00075 (3/5) hydrogenase expression/formation protein HypD
TIGR00074 (3/5) hydrogenase assembly chaperone HypC/HupF
PF12833 (3/5) Helix-turn-helix domain
PF12625 (3/5) Arabinose-binding domain of AraC transcription regulator, N-term
PF03583 (3/5) Secretory lipase
PF02769 (3/5) AIR synthase related protein, C-terminal domain
PF01924 (3/5) Hydrogenase formation hypA family
PF01455 (3/5) HupF/HypC family
PF00586 (3/5) AIR synthase related protein, N-terminal domain

precursor_groups_8651 569.88 +- 178.51 3 0 3 3 0.01 +- 0.00 3 4

PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (3/3) Radical SAM superfamily
PF00248 (3/3) Aldo/keto reductase family
PF12746 (2/3) GNAT acetyltransferase

precursor_groups_64828 1956.02 +- 301.48 2 0 0 0 0.01 +- 0.00 2 6

PF08532 (2/2) Beta-galactosidase trimerisation domain
PF04616 (2/2) Glycosyl hydrolases family 43
PF02449 (2/2) Beta-galactosidase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_54127 746.09 +- 12.83 2 0 0 0 0.02 +- 0.02 2 7

PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF03704 (1/2) Bacterial transcriptional activator domain

precursor_groups_8590 42.56 +- 13.89 4 0 0 0 0.09 +- 0.09 4 5

PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (4/4) Major Facilitator Superfamily
PF00107 (4/4) Zinc-binding dehydrogenase
PF01636 (3/4) Phosphotransferase enzyme family

precursor_groups_7915 1600.99 +- 895.71 9 0 9 0 0.01 +- 0.01 9 11

TIGR01733 (9/9) amino acid adenylation domain
PF16197 (9/9) Ketoacyl-synthetase C-terminal extension
PF13535 (9/9) ATP-grasp domain
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF07690 (9/9) Major Facilitator Superfamily
PF02801 (9/9) Beta-ketoacyl synthase, C-terminal domain
PF00975 (9/9) Thioesterase domain
PF00698 (9/9) Acyl transferase domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00109 (9/9) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_26216 134.88 +- 15.76 4 0 0 0 0.20 +- 0.33 4 7

TIGR01915 (4/4) NADPH-dependent F420 reductase
PF13560 (4/4) Helix-turn-helix domain
PF13088 (4/4) BNR repeat-like domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component

precursor_groups_59201 37.45 +- 0.00 2 0 2 0 0.08 +- 0.05 2 5

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF00891 (2/2) O-methyltransferase domain
PF00501 (2/2) AMP-binding enzyme

precursor_groups_35953 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase

precursor_groups_28511 3085.20 +- 347.42 4 0 4 0 0.01 +- 0.01 4 16

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13560 (4/4) Helix-turn-helix domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13304 (4/4) AAA domain, putative AbiEii toxin, Type IV TA system
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00977 (4/4) Histidine biosynthesis protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00155 (4/4) Aminotransferase class I and II
PF00107 (4/4) Zinc-binding dehydrogenase
PF00005 (4/4) ABC transporter

precursor_groups_4248 664.57 +- 367.43 2 0 2 0 0.02 +- 0.02 2 8

TIGR01733 (2/2) amino acid adenylation domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_20766 55.69 +- 1.94 2 0 0 0 0.18 +- 0.23 2 8

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13454 (2/2) FAD-NAD(P)-binding
PF02983 (2/2) Alpha-lytic protease prodomain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
PF00005 (2/2) ABC transporter

precursor_groups_80473 388.50 +- 1.50 2 0 0 0 0.01 +- 0.00 2 6

TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (2/2) SseB protein N-terminal domain
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family

precursor_groups_1729 51.10 +- 16.01 3 0 0 0 0.13 +- 0.25 3 5

PF13560 (3/3) Helix-turn-helix domain
PF07690 (3/3) Major Facilitator Superfamily
PF04149 (3/3) Domain of unknown function (DUF397)
PF03372 (3/3) Endonuclease/Exonuclease/phosphatase family
PF00561 (3/3) alpha/beta hydrolase fold

precursor_groups_64911 55.71 +- 30.95 2 0 0 0 0.05 +- 0.09 2 2

PF07876 (2/2) Stress responsive A/B Barrel Domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family

precursor_groups_34366 1186.67 +- 103.33 2 0 0 0 0.01 +- 0.00 2 9

PF16353 (2/2) Domain of unknown function(DUF4981)
PF14310 (2/2) Fibronectin type III-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00232 (2/2) Glycosyl hydrolase family 1

precursor_groups_62603 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 4

PF11999 (2/2) Protein of unknown function (DUF3494)
PF05199 (2/2) GMC oxidoreductase
PF01833 (2/2) IPT/TIG domain
PF00732 (2/2) GMC oxidoreductase

precursor_groups_4930 143.55 +- 110.11 5 0 0 0 0.09 +- 0.19 5 6

TIGR01180 (5/5) putative alpha-1,2-mannosidase
PF17678 (5/5) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (5/5) Glycosyl hydrolase family 92
PF07488 (5/5) Glycosyl hydrolase family 67 middle domain
PF07477 (5/5) Glycosyl hydrolase family 67 C-terminus
PF00754 (5/5) F5/8 type C domain

precursor_groups_58308 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 6

TIGR02418 (2/2) acetolactate synthase, catabolic
TIGR01252 (2/2) alpha-acetolactate decarboxylase
PF03306 (2/2) Alpha-acetolactate decarboxylase
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_8026 225.75 +- 32.25 2 0 2 2 0.01 +- 0.00 2 4

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding

precursor_groups_10171 305.69 +- 55.04 8 0 0 0 0.09 +- 0.22 8 16

TIGR03177 (8/8) Flp pilus assembly protein CpaB
PF16976 (8/8) Flp pilus assembly protein RcpC/CpaB
PF15648 (8/8) Restriction endonuclease fold toxin 5
PF13614 (8/8) AAA domain
PF13400 (8/8) Putative Flp pilus-assembly TadE/G-like
PF13231 (8/8) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07811 (8/8) TadE-like protein
PF07730 (8/8) Histidine kinase
PF00691 (8/8) OmpA family
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00496 (8/8) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF00437 (8/8) Type II/IV secretion system protein
PF00196 (8/8) Bacterial regulatory proteins, luxR family
PF00072 (8/8) Response regulator receiver domain
PF00005 (8/8) ABC transporter

precursor_groups_15457 353.47 +- 479.80 3 0 1 2 0.09 +- 0.21 3 4

PF06906 (3/3) Protein of unknown function (DUF1272)
PF13360 (2/3) PQQ-like domain
PF01925 (2/3) Sulfite exporter TauE/SafE
PF01329 (2/3) Pterin 4 alpha carbinolamine dehydratase

precursor_groups_38 134.88 +- 15.76 4 0 0 0 0.20 +- 0.33 4 7

TIGR01915 (4/4) NADPH-dependent F420 reductase
PF13560 (4/4) Helix-turn-helix domain
PF13088 (4/4) BNR repeat-like domain
PF03807 (4/4) NADP oxidoreductase coenzyme F420-dependent
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01135 (4/4) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component

precursor_groups_28603 75.25 +- 32.25 2 0 0 1 0.07 +- 0.13 2 19

TIGR00180 (2/2) ParB/RepB/Spo0J family partition protein
PF13614 (2/2) AAA domain
PF13577 (2/2) SnoaL-like domain
PF02195 (2/2) ParB-like nuclease domain
TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF17929 (1/2) Tetracyclin repressor-like, C-terminal domain
PF17677 (1/2) Glycosyl hydrolases family 38 C-terminal beta sandwich domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (1/2) Helix-turn-helix domain
PF12852 (1/2) Cupin
PF08535 (1/2) KorB domain
PF07748 (1/2) Glycosyl hydrolases family 38 C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
PF01738 (1/2) Dienelactone hydrolase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family
PF00106 (1/2) short chain dehydrogenase

precursor_groups_1291 266.16 +- 224.48 2 0 1 0 0.04 +- 0.05 2 19

TIGR04444 (1/2) chorismatase, FkbO/Hyg5 family
PF17645 (1/2) Arylmalonate decarboxylase
PF13520 (1/2) Amino acid permease
PF13439 (1/2) Glycosyltransferase Family 4
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF07690 (1/2) Major Facilitator Superfamily
PF06339 (1/2) Ectoine synthase
PF04101 (1/2) Glycosyltransferase family 28 C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02709 (1/2) N-terminal domain of galactosyltransferase
PF01841 (1/2) Transglutaminase-like superfamily
PF01474 (1/2) Class-II DAHP synthetase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00534 (1/2) Glycosyl transferases group 1
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase

precursor_groups_76863 25.84 +- 12.40 2 0 0 0 0.15 +- 0.29 2 6

TIGR00649 (2/2) beta-CASP ribonuclease, RNase J family
PF17770 (2/2) Ribonuclease J C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF07521 (2/2) Zn-dependent metallo-hydrolase RNA specificity domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_22580 161.60 +- 98.40 2 0 2 0 0.08 +- 0.25 2 15

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF06094 (2/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF01522 (2/2) Polysaccharide deacetylase
PF17765 (1/2) MmyB-like transcription regulator ligand binding domain
PF13560 (1/2) Helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01039 (1/2) Carboxyl transferase domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00155 (1/2) Aminotransferase class I and II

precursor_groups_1298 179.29 +- 128.76 17 0 15 17 0.03 +- 0.03 17 3

PF00733 (17/17) Asparagine synthase
PF13302 (16/17) Acetyltransferase (GNAT) domain
PF13471 (15/17) Transglutaminase-like superfamily

precursor_groups_80573 2492.63 +- 2031.37 2 0 0 2 0.03 +- 0.06 2 30

TIGR03812 (2/2) tyrosine decarboxylase MnfA
PF17755 (2/2) UvrA DNA-binding domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF16169 (2/2) Domain of unknown function (DUF4872)
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (2/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (2/2) DNA alkylation repair enzyme
PF08241 (2/2) Methyltransferase domain
PF04879 (2/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (2/2) Radical SAM superfamily
PF03241 (2/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02310 (2/2) B12 binding domain
PF02195 (2/2) ParB-like nuclease domain
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF01061 (2/2) ABC-2 type transporter
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00501 (2/2) AMP-binding enzyme
PF00384 (2/2) Molybdopterin oxidoreductase
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00282 (2/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF12833 (1/2) Helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family

precursor_groups_74967 176.61 +- 38.39 2 0 2 0 0.02 +- 0.01 2 3

PF08241 (2/2) Methyltransferase domain
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00348 (2/2) Polyprenyl synthetase

precursor_groups_740 39.67 +- 30.00 4 0 0 0 0.11 +- 0.19 4 9

TIGR03026 (2/4) nucleotide sugar dehydrogenase
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
PF03721 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02156 (2/4) Glycosyl hydrolase family 26
PF00984 (2/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00132 (2/4) Bacterial transferase hexapeptide (six repeats)

precursor_groups_17129 22.42 +- 9.83 2 0 0 0 0.11 +- 0.09 2 3

PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF01323 (2/2) DSBA-like thioredoxin domain

precursor_groups_1501 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein

precursor_groups_1502 117.58 +- 145.76 14 0 0 0 0.07 +- 0.11 14 2

PF00877 (12/14) NlpC/P60 family
PF11203 (7/14) Putative type VII ESX secretion system translocon, EccE

precursor_groups_4023 16.30 +- 0.43 3 0 0 0 0.25 +- 0.40 3 4

PF13560 (3/3) Helix-turn-helix domain
PF13508 (3/3) Acetyltransferase (GNAT) domain
PF11228 (3/3) Protein of unknown function (DUF3027)
PF04149 (3/3) Domain of unknown function (DUF397)

precursor_groups_1057 198.48 +- 146.27 24 0 23 24 0.04 +- 0.10 24 4

TIGR03891 (24/24) thiopeptide-type bacteriocin biosynthesis domain
PF05147 (23/24) Lanthionine synthetase C-like protein
PF14028 (22/24) Lantibiotic biosynthesis dehydratase C-term
PF04738 (21/24) Lantibiotic dehydratase, N terminus

precursor_groups_30846 265.46 +- 77.49 3 0 0 0 0.22 +- 0.21 3 20

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03567 (3/3) FMN reductase
TIGR01728 (3/3) ABC transporter, substrate-binding protein, aliphatic sulfonates family
TIGR01726 (3/3) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF09084 (3/3) NMT1/THI5 like
PF08445 (3/3) FR47-like protein
PF03358 (3/3) NADPH-dependent FMN reductase
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00497 (3/3) Bacterial extracellular solute-binding proteins, family 3
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR00738 (2/3) Rrf2 family protein
PF13410 (2/3) Glutathione S-transferase, C-terminal domain
PF13187 (2/3) 4Fe-4S dicluster domain
PF08028 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF02910 (2/3) Fumarate reductase flavoprotein C-term
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/3) Transcriptional regulator
PF00890 (2/3) FAD binding domain

precursor_groups_37819 397.87 +- 89.63 2 0 1 0 0.04 +- 0.10 2 16

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF02729 (2/2) Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00185 (2/2) Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00144 (2/2) Beta-lactamase
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (1/2) amino acid adenylation domain
PF03621 (1/2) MbtH-like protein
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01609 (1/2) Transposase DDE domain
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme

precursor_groups_21565 1183.93 +- 983.27 2 0 2 0 0.07 +- 0.20 2 13

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF03621 (2/2) MbtH-like protein
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (2/2) Aminotransferase class-III

precursor_groups_4029 10.98 +- 0.23 2 0 1 0 0.18 +- 0.18 2 5

PF16697 (2/2) Inner membrane component of T3SS, cytoplasmic domain
PF01061 (2/2) ABC-2 type transporter
PF00498 (2/2) FHA domain
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter

precursor_groups_37812 27.87 +- 13.97 3 0 0 0 0.10 +- 0.11 3 3

TIGR03696 (3/3) RHS repeat-associated core domain
PF04672 (3/3) S-adenosyl methyltransferase
PF01636 (3/3) Phosphotransferase enzyme family

precursor_groups_80653 225.44 +- 25.27 2 0 0 0 0.04 +- 0.02 2 9

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14310 (2/2) Fibronectin type III-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_49462 126.16 +- 12.76 2 0 2 0 0.17 +- 0.31 2 27

TIGR01733 (2/2) amino acid adenylation domain
TIGR01208 (2/2) glucose-1-phosphate thymidylyltransferase
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR01181 (2/2) dTDP-glucose 4,6-dehydratase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13822 (2/2) Acyl-CoA carboxylase epsilon subunit
PF13349 (2/2) Putative adhesin
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF05534 (2/2) HicB family
PF03559 (2/2) NDP-hexose 2,3-dehydratase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01494 (2/2) FAD binding domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01061 (2/2) ABC-2 type transporter
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF01039 (2/2) Carboxyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00483 (2/2) Nucleotidyl transferase
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_15071 918.88 +- 398.11 7 0 0 0 0.02 +- 0.01 7 10

PF13407 (7/7) Periplasmic binding protein domain
PF11721 (7/7) Malectin domain
PF10054 (7/7) Predicted periplasmic lipoprotein (DUF2291)
PF07632 (7/7) Protein of unknown function (DUF1593)
PF04198 (7/7) Putative sugar-binding domain
PF03422 (7/7) Carbohydrate binding module (family 6)
PF02653 (7/7) Branched-chain amino acid transport system / permease component
PF01261 (7/7) Xylose isomerase-like TIM barrel
PF00801 (7/7) PKD domain
PF00005 (7/7) ABC transporter

precursor_groups_40127 23.19 +- 7.53 3 0 0 0 0.19 +- 0.33 3 12

TIGR02103 (3/3) alpha-1,6-glucosidases, pullulanase-type
PF17967 (3/3) Pullulanase N2 domain
PF17189 (3/3) Glycosyl hydrolase family 30 beta sandwich domain
PF11852 (3/3) Domain of unknown function (DUF3372)
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF03714 (3/3) Bacterial pullanase-associated domain
PF02962 (3/3) 5-carboxymethyl-2-hydroxymuconate isomerase
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02057 (3/3) Glycosyl hydrolase family 59
PF00128 (3/3) Alpha amylase, catalytic domain
PF00072 (3/3) Response regulator receiver domain

precursor_groups_30283 1205.04 +- 76.27 4 0 4 4 0.01 +- 0.00 4 7

TIGR04353 (4/4) PqqD family protein, HPr-rel-A system
TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00005 (4/4) ABC transporter

precursor_groups_60560 1290.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 5

PF13242 (2/2) HAD-hyrolase-like
PF06182 (2/2) ABC-2 family transporter protein
PF04655 (2/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF00005 (2/2) ABC transporter

precursor_groups_40278 56.57 +- 48.19 2 0 0 0 0.14 +- 0.10 2 13

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR03564 (1/2) F420-dependent oxidoreductase, MSMEG_4879 family
TIGR01392 (1/2) homoserine O-acetyltransferase
TIGR01326 (1/2) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF13671 (1/2) AAA domain
PF07920 (1/2) Protein of unknown function (DUF1684)
PF01638 (1/2) HxlR-like helix-turn-helix
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

precursor_groups_45577 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal

precursor_groups_44889 21.80 +- 7.09 2 0 2 0 0.10 +- 0.08 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13427 (2/2) Domain of unknown function (DUF4111)
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF01909 (2/2) Nucleotidyltransferase domain

precursor_groups_41677 109.47 +- 59.73 3 0 2 0 0.07 +- 0.06 3 4

PF13673 (3/3) Acetyltransferase (GNAT) domain
PF13411 (3/3) MerR HTH family regulatory protein
PF08534 (3/3) Redoxin
PF00701 (3/3) Dihydrodipicolinate synthetase family

precursor_groups_46955 26.26 +- 10.40 3 0 0 0 0.14 +- 0.23 3 3

PF13649 (3/3) Methyltransferase domain
PF00089 (3/3) Trypsin
PF04978 (2/3) Protein of unknown function (DUF664)

precursor_groups_21962 23.69 +- 9.72 5 0 2 0 0.15 +- 0.11 5 5

PF07992 (5/5) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (5/5) BFD-like [2Fe-2S] binding domain
PF02782 (5/5) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (5/5) FAD dependent oxidoreductase
PF00370 (5/5) FGGY family of carbohydrate kinases, N-terminal domain

precursor_groups_3833 57.86 +- 12.51 2 0 0 0 0.09 +- 0.12 2 7

TIGR01494 (2/2) HAD ATPase, P-type, family IC
PF08892 (2/2) YqcI/YcgG family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00689 (2/2) Cation transporting ATPase, C-terminus
PF13377 (1/2) Periplasmic binding protein-like domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00122 (1/2) E1-E2 ATPase

precursor_groups_5994 103.17 +- 39.91 6 0 0 0 0.20 +- 0.32 6 11

TIGR03177 (6/6) Flp pilus assembly protein CpaB
PF16976 (6/6) Flp pilus assembly protein RcpC/CpaB
PF08666 (6/6) SAF domain
PF07811 (6/6) TadE-like protein
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
PF13400 (5/6) Putative Flp pilus-assembly TadE/G-like
PF06564 (5/6) Cellulose biosynthesis protein BcsQ
PF00691 (5/6) OmpA family
PF13977 (4/6) BetI-type transcriptional repressor, C-terminal
PF00440 (4/6) Bacterial regulatory proteins, tetR family

precursor_groups_5993 50.05 +- 17.55 2 0 2 0 0.13 +- 0.18 2 27

PF04116 (2/2) Fatty acid hydroxylase superfamily
TIGR01733 (1/2) amino acid adenylation domain
PF17754 (1/2) MftR C-terminal domain
PF16884 (1/2) N-terminal domain of oxidoreductase
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF06386 (1/2) Gas vesicle synthesis protein GvpL/GvpF
PF05800 (1/2) Gas vesicle synthesis protein GvpO
PF05121 (1/2) Gas vesicle protein K
PF05120 (1/2) Gas vesicle protein G
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00975 (1/2) Thioesterase domain
PF00741 (1/2) Gas vesicle protein
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450

precursor_groups_7824 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain

precursor_groups_41225 636.32 +- 221.68 2 0 0 0 0.02 +- 0.03 2 3

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily

precursor_groups_5193 45.92 +- 25.86 4 0 3 0 0.13 +- 0.13 4 2

PF02031 (4/4) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (4/4) LysE type translocator

precursor_groups_1475 56.36 +- 0.21 3 0 0 0 0.25 +- 0.34 3 9

TIGR00879 (3/3) MFS transporter, sugar porter (SP) family
TIGR00745 (3/3) 2-dehydropantoate 2-reductase
PF08546 (3/3) Ketopantoate reductase PanE/ApbA C terminal
PF02894 (3/3) Oxidoreductase family, C-terminal alpha/beta domain
PF02558 (3/3) Ketopantoate reductase PanE/ApbA
PF01925 (3/3) Sulfite exporter TauE/SafE
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00083 (3/3) Sugar (and other) transporter

precursor_groups_21495 194.83 +- 65.20 3 0 3 3 0.06 +- 0.05 3 6

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00005 (3/3) ABC transporter

precursor_groups_49605 509.69 +- 54.69 2 0 2 0 0.01 +- 0.00 2 9

TIGR00421 (2/2) polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
TIGR00148 (2/2) decarboxylase, UbiD family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF02441 (2/2) Flavoprotein
PF01977 (2/2) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily

precursor_groups_9242 29.70 +- 3.24 10 0 10 0 0.15 +- 0.15 10 7

PF13620 (10/10) Carboxypeptidase regulatory-like domain
PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF11512 (10/10) Agrobacterium tumefaciens protein Atu4866
PF04264 (10/10) YceI-like domain
PF00005 (10/10) ABC transporter
PF04978 (9/10) Protein of unknown function (DUF664)
PF02585 (5/10) GlcNAc-PI de-N-acetylase

precursor_groups_16507 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase

precursor_groups_7281 37.66 +- 8.65 5 0 2 0 0.14 +- 0.17 5 8

PF17754 (5/5) MftR C-terminal domain
PF08445 (5/5) FR47-like protein
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter
PF13561 (3/5) Enoyl-(Acyl carrier protein) reductase

precursor_groups_14655 29.25 +- 0.75 2 0 2 0 0.12 +- 0.13 2 6

TIGR00377 (2/2) anti-anti-sigma factor
PF13466 (2/2) STAS domain
PF04191 (2/2) Phospholipid methyltransferase
PF02541 (2/2) Ppx/GppA phosphatase family
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily

precursor_groups_2404 152.42 +- 139.42 2 0 1 0 0.08 +- 0.08 2 17

TIGR01733 (1/2) amino acid adenylation domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13649 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08021 (1/2) Siderophore-interacting FAD-binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF04954 (1/2) Siderophore-interacting protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01756 (1/2) Acyl-CoA oxidase
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (1/2) ABC transporter

precursor_groups_2407 66.42 +- 20.13 7 0 0 0 0.04 +- 0.04 7 3

PF18368 (7/7) Exo-beta-D-glucosaminidase Ig-fold domain
PF07166 (7/7) Protein of unknown function (DUF1398)
PF00703 (7/7) Glycosyl hydrolases family 2

precursor_groups_46711 138.06 +- 2.67 2 0 0 0 0.22 +- 0.15 2 12

TIGR01726 (2/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00738 (2/2) Rrf2 family protein
PF09084 (2/2) NMT1/THI5 like
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02082 (2/2) Transcriptional regulator
PF01925 (2/2) Sulfite exporter TauE/SafE
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (2/2) ABC transporter

precursor_groups_6358 258.23 +- 98.52 12 0 0 0 0.03 +- 0.03 12 15

PF17754 (12/12) MftR C-terminal domain
PF14525 (12/12) AraC-binding-like domain
PF12833 (12/12) Helix-turn-helix domain
PF08240 (12/12) Alcohol dehydrogenase GroES-like domain
PF04444 (12/12) Catechol dioxygenase N terminus
PF02776 (12/12) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (12/12) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01494 (12/12) FAD binding domain
PF01425 (12/12) Amidase
PF01047 (12/12) MarR family
PF00775 (12/12) Dioxygenase
PF00465 (12/12) Iron-containing alcohol dehydrogenase
PF00205 (12/12) Thiamine pyrophosphate enzyme, central domain
PF00107 (12/12) Zinc-binding dehydrogenase
PF00106 (12/12) short chain dehydrogenase

precursor_groups_20814 195.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01435 (2/2) Peptidase family M48
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_51956 453.00 +- 63.00 2 0 0 0 0.01 +- 0.00 2 4

PF05853 (2/2) beta-keto acid cleavage enzyme
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_50420 29.66 +- 0.00 2 0 0 0 0.13 +- 0.05 2 5

PF14542 (2/2) GCN5-related N-acetyl-transferase
PF07969 (2/2) Amidohydrolase family
PF07681 (2/2) DoxX
PF06912 (2/2) Protein of unknown function (DUF1275)
PF00857 (2/2) Isochorismatase family

precursor_groups_691 49.30 +- 56.36 3 0 3 0 0.22 +- 0.32 3 11

PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01039 (3/3) Carboxyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00364 (3/3) Biotin-requiring enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF18369 (2/3) Polyketide synthase dimerisation element domain
PF16197 (2/3) Ketoacyl-synthetase C-terminal extension
PF14765 (2/3) Polyketide synthase dehydratase
PF13602 (2/3) Zinc-binding dehydrogenase
PF08659 (2/3) KR domain
PF00698 (2/3) Acyl transferase domain

precursor_groups_13454 314.36 +- 46.96 3 0 0 0 0.03 +- 0.05 3 11

PF14200 (2/3) Ricin-type beta-trefoil lectin domain-like
PF13416 (2/3) Bacterial extracellular solute-binding protein
PF13229 (2/3) Right handed beta helix region
PF07745 (2/3) Glycosyl hydrolase family 53
PF07532 (2/3) Bacterial Ig-like domain (group 4)
PF04616 (2/3) Glycosyl hydrolases family 43
PF03583 (2/3) Secretory lipase
PF03422 (2/3) Carbohydrate binding module (family 6)
PF01522 (2/3) Polysaccharide deacetylase
PF00754 (2/3) F5/8 type C domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component

precursor_groups_345 235.26 +- 369.14 60 0 13 2 0.07 +- 0.13 60 12

PF01361 (60/60) Tautomerase enzyme
PF03466 (52/60) LysR substrate binding domain
PF00126 (52/60) Bacterial regulatory helix-turn-helix protein, lysR family
TIGR01524 (33/60) magnesium-translocating P-type ATPase
PF17668 (33/60) Acetyltransferase (GNAT) domain
PF13530 (33/60) Sterol carrier protein domain
PF13527 (33/60) Acetyltransferase (GNAT) domain
PF02308 (33/60) MgtC family
PF00702 (33/60) haloacid dehalogenase-like hydrolase
PF00690 (33/60) Cation transporter/ATPase, N-terminus
PF00689 (33/60) Cation transporting ATPase, C-terminus
PF00122 (33/60) E1-E2 ATPase

precursor_groups_2436 149.68 +- 43.04 4 0 2 0 0.11 +- 0.29 4 23

TIGR01733 (2/4) amino acid adenylation domain
TIGR01141 (2/4) histidinol-phosphate transaminase
TIGR00797 (2/4) MATE efflux family protein
PF14269 (2/4) Arylsulfotransferase (ASST)
PF13649 (2/4) Methyltransferase domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF08545 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02784 (2/4) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (2/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/4) Acyl-CoA dehydrogenase, middle domain
PF02423 (2/4) Ornithine cyclodeaminase/mu-crystallin family
PF01554 (2/4) MatE
PF01497 (2/4) Periplasmic binding protein
PF00860 (2/4) Permease family
PF00664 (2/4) ABC transporter transmembrane region
PF00652 (2/4) Ricin-type beta-trefoil lectin domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00441 (2/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme
PF00155 (2/4) Aminotransferase class I and II
PF00005 (2/4) ABC transporter

precursor_groups_1188 180.76 +- 121.38 4 0 4 0 0.08 +- 0.16 4 15

TIGR03150 (4/4) beta-ketoacyl-acyl-carrier-protein synthase II
TIGR00517 (4/4) acyl carrier protein
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF00171 (4/4) Aldehyde dehydrogenase family
PF00155 (4/4) Aminotransferase class I and II
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_1189 226.97 +- 160.03 2 0 0 0 0.12 +- 0.25 2 15

TIGR03005 (1/2) ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA
TIGR03004 (1/2) ectoine/hydroxyectoine ABC transporter, permease protein EhuC
TIGR03003 (1/2) ectoine/hydroxyectoine ABC transporter, permease protein EhuD
TIGR02995 (1/2) ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB
PF17645 (1/2) Arylmalonate decarboxylase
PF09339 (1/2) IclR helix-turn-helix domain
PF04464 (1/2) CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PF04138 (1/2) GtrA-like protein
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01614 (1/2) Bacterial transcriptional regulator
PF01425 (1/2) Amidase
PF00535 (1/2) Glycosyl transferase family 2
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00005 (1/2) ABC transporter

precursor_groups_23430 130.76 +- 113.43 4 0 0 0 0.09 +- 0.23 4 4

PF13560 (4/4) Helix-turn-helix domain
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF00069 (4/4) Protein kinase domain

precursor_groups_58150 57.15 +- 11.27 2 0 0 0 0.06 +- 0.08 2 15

TIGR03026 (1/2) nucleotide sugar dehydrogenase
TIGR01208 (1/2) glucose-1-phosphate thymidylyltransferase
TIGR01181 (1/2) dTDP-glucose 4,6-dehydratase
PF16363 (1/2) GDP-mannose 4,6 dehydratase
PF13489 (1/2) Methyltransferase domain
PF13384 (1/2) Homeodomain-like domain
PF08484 (1/2) C-methyltransferase C-terminal domain
PF08421 (1/2) Putative zinc binding domain
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03559 (1/2) NDP-hexose 2,3-dehydratase
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00535 (1/2) Glycosyl transferase family 2
PF00483 (1/2) Nucleotidyl transferase

precursor_groups_14259 293.75 +- 130.25 7 0 3 0 0.04 +- 0.16 7 7

TIGR01733 (7/7) amino acid adenylation domain
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF07690 (7/7) Major Facilitator Superfamily
PF00975 (7/7) Thioesterase domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme

precursor_groups_70666 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_groups_36039 38.01 +- 2.35 2 0 0 0 0.21 +- 0.23 2 3

PF13411 (2/2) MerR HTH family regulatory protein
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF01427 (2/2) D-ala-D-ala dipeptidase

precursor_groups_46139 286.45 +- 187.28 3 0 0 0 0.03 +- 0.05 3 12

TIGR00229 (3/3) PAS domain S-box protein
PF17203 (3/3) Single cache domain 3
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01590 (3/3) GAF domain
PF00989 (3/3) PAS fold
PF07969 (2/3) Amidohydrolase family
PF07729 (2/3) FCD domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family

precursor_groups_76120 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_49114 482.86 +- 37.14 2 0 0 0 0.02 +- 0.01 2 8

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF17765 (2/2) MmyB-like transcription regulator ligand binding domain
PF13560 (2/2) Helix-turn-helix domain
PF13531 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter

precursor_groups_5370 8.57 +- 0.00 2 0 0 0 0.23 +- 0.31 2 3

TIGR02469 (2/2) precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
TIGR01465 (2/2) precorrin-4 C11-methyltransferase
PF00590 (2/2) Tetrapyrrole (Corrin/Porphyrin) Methylases

precursor_groups_56867 36.90 +- 9.53 2 0 0 0 0.13 +- 0.14 2 12

PF12697 (2/2) Alpha/beta hydrolase family
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00106 (2/2) short chain dehydrogenase
PF00072 (2/2) Response regulator receiver domain
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (1/2) Major Facilitator Superfamily
PF03625 (1/2) Domain of unknown function DUF302
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00027 (1/2) Cyclic nucleotide-binding domain

precursor_groups_17122 216.46 +- 59.99 6 0 0 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF02575 (6/6) YbaB/EbfC DNA-binding family
PF04488 (5/6) Glycosyltransferase sugar-binding region containing DXD motif

precursor_groups_24283 3085.20 +- 347.42 4 0 4 0 0.01 +- 0.01 4 16

TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
PF13649 (4/4) Methyltransferase domain
PF13560 (4/4) Helix-turn-helix domain
PF13450 (4/4) NAD(P)-binding Rossmann-like domain
PF13304 (4/4) AAA domain, putative AbiEii toxin, Type IV TA system
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07993 (4/4) Male sterility protein
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00977 (4/4) Histidine biosynthesis protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00155 (4/4) Aminotransferase class I and II
PF00107 (4/4) Zinc-binding dehydrogenase
PF00005 (4/4) ABC transporter

precursor_groups_16430 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_24285 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 4

PF12802 (2/2) MarR family
PF09335 (2/2) SNARE associated Golgi protein
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain

precursor_groups_29391 48.41 +- 31.27 2 0 1 0 0.16 +- 0.14 2 10

PF17648 (2/2) Family of unknown function (DUF5519)
PF13377 (2/2) Periplasmic binding protein-like domain
PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01670 (2/2) Glycosyl hydrolase family 12
PF00553 (2/2) Cellulose binding domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF13569 (1/2) Domain of unknown function (DUF4132)
PF13411 (1/2) MerR HTH family regulatory protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF02767 (1/2) DNA polymerase III beta subunit, central domain

precursor_groups_2575 187.61 +- 144.53 13 0 13 0 0.08 +- 0.17 13 4

PF07690 (13/13) Major Facilitator Superfamily
PF03756 (13/13) A-factor biosynthesis hotdog domain
PF00916 (13/13) Sulfate permease family
PF00484 (13/13) Carbonic anhydrase

precursor_groups_63631 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase

precursor_groups_2140 95.55 +- 39.26 4 0 2 0 0.10 +- 0.07 4 5

PF13411 (4/4) MerR HTH family regulatory protein
PF03476 (4/4) MOSC N-terminal beta barrel domain
PF03473 (4/4) MOSC domain
PF01551 (4/4) Peptidase family M23
PF00248 (4/4) Aldo/keto reductase family

precursor_groups_84793 615.47 +- 545.53 2 0 2 0 0.07 +- 0.20 2 14

TIGR00262 (2/2) tryptophan synthase, alpha subunit
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06339 (2/2) Ectoine synthase
PF03621 (2/2) MbtH-like protein
PF02812 (2/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00697 (2/2) N-(5'phosphoribosyl)anthranilate (PRA) isomerase
PF00591 (2/2) Glycosyl transferase family, a/b domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00290 (2/2) Tryptophan synthase alpha chain
PF00218 (2/2) Indole-3-glycerol phosphate synthase
PF00208 (2/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase

precursor_groups_63639 136.44 +- 123.56 2 0 0 0 0.08 +- 0.15 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09286 (2/2) Pro-kumamolisin, activation domain
PF03713 (2/2) Domain of unknown function (DUF305)
PF00082 (2/2) Subtilase family

precursor_groups_39099 402.66 +- 235.52 2 0 0 0 0.02 +- 0.02 2 5

PF12704 (2/2) MacB-like periplasmic core domain
PF11350 (2/2) Protein of unknown function (DUF3152)
PF02687 (2/2) FtsX-like permease family
PF01471 (2/2) Putative peptidoglycan binding domain
PF00005 (2/2) ABC transporter

precursor_groups_53136 200.54 +- 186.46 2 0 0 0 0.07 +- 0.14 2 8

PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF11361 (2/2) Protein of unknown function (DUF3159)
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00667 (1/2) FAD binding domain
PF00258 (1/2) Flavodoxin
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00067 (1/2) Cytochrome P450

precursor_groups_34945 30.60 +- 5.27 3 0 0 0 0.11 +- 0.14 3 11

PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12806 (3/3) Acetyl-CoA dehydrogenase C-terminal like
PF12418 (3/3) Acyl-CoA dehydrogenase N terminal
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00664 (3/3) ABC transporter transmembrane region
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00005 (3/3) ABC transporter

precursor_groups_33137 43.20 +- 22.07 3 0 1 0 0.10 +- 0.07 3 5

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03919 (3/3) type VII secretion protein EccB
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/3) YbaB/EbfC DNA-binding family

precursor_groups_84800 148.29 +- 74.57 2 0 0 0 0.03 +- 0.02 2 6

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13377 (2/2) Periplasmic binding protein-like domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF05592 (2/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_36452 77.19 +- 36.56 2 0 0 0 0.15 +- 0.20 2 9

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13649 (2/2) Methyltransferase domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00005 (2/2) ABC transporter

precursor_groups_42218 1361.71 +- 233.20 2 0 0 0 0.02 +- 0.00 2 17

TIGR02118 (2/2) conserved hypothetical protein
TIGR01930 (2/2) acetyl-CoA C-acyltransferase
PF17932 (2/2) Tetracyclin repressor-like, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07110 (2/2) EthD domain
PF02803 (2/2) Thiolase, C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01796 (2/2) DUF35 OB-fold domain, acyl-CoA-associated
PF01636 (2/2) Phosphotransferase enzyme family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00108 (2/2) Thiolase, N-terminal domain

precursor_groups_1223 47.59 +- 37.42 39 0 1 0 0.12 +- 0.11 39 5

PF00561 (38/39) alpha/beta hydrolase fold
TIGR00456 (36/39) arginine--tRNA ligase
PF05746 (36/39) DALR anticodon binding domain
PF03485 (36/39) Arginyl tRNA synthetase N terminal domain
PF00750 (36/39) tRNA synthetases class I (R)

precursor_groups_2976 362.99 +- 177.76 6 0 0 0 0.02 +- 0.01 6 6

PF07690 (6/6) Major Facilitator Superfamily
PF04909 (6/6) Amidohydrolase
PF04444 (6/6) Catechol dioxygenase N terminus
PF01494 (6/6) FAD binding domain
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase

precursor_groups_14492 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II

precursor_groups_47843 19.22 +- 6.18 3 0 0 0 0.15 +- 0.25 3 4

PF13641 (3/3) Glycosyltransferase like family 2
PF01757 (3/3) Acyltransferase family
PF01522 (3/3) Polysaccharide deacetylase
PF01381 (2/3) Helix-turn-helix

precursor_groups_35422 10.29 +- 0.89 3 0 3 0 0.19 +- 0.39 3 6

TIGR00876 (3/3) transaldolase
PF13185 (3/3) GAF domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF04686 (3/3) Streptomyces sporulation and cell division protein, SsgA
PF01590 (3/3) GAF domain
PF00923 (3/3) Transaldolase/Fructose-6-phosphate aldolase

precursor_groups_24048 111.82 +- 15.07 2 0 2 0 0.22 +- 0.29 2 7

TIGR03797 (2/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (2/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (2/2) HlyD family secretion protein
PF03412 (2/2) Peptidase C39 family
PF01436 (2/2) NHL repeat
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter

precursor_groups_521 40.65 +- 5.03 3 0 0 0 0.09 +- 0.15 3 7

TIGR00924 (2/3) amino acid/peptide transporter (Peptide:H+ symporter)
PF13560 (2/3) Helix-turn-helix domain
PF13520 (2/3) Amino acid permease
PF11716 (2/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07883 (2/3) Cupin domain
PF01266 (2/3) FAD dependent oxidoreductase
PF00854 (2/3) POT family

precursor_groups_11900 107.83 +- 59.26 7 0 0 0 0.04 +- 0.06 7 2

PF01557 (7/7) Fumarylacetoacetate (FAA) hydrolase family
PF00753 (7/7) Metallo-beta-lactamase superfamily

precursor_groups_9451 167.40 +- 12.60 2 0 2 0 0.02 +- 0.01 2 4

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF03795 (2/2) YCII-related domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_13207 499.47 +- 326.13 2 0 0 0 0.02 +- 0.03 2 11

PF13333 (1/2) Integrase core domain
PF12146 (1/2) Serine aminopeptidase, S33
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/2) FAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/2) Integrase core domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00106 (1/2) short chain dehydrogenase

precursor_groups_529 320.96 +- 334.05 3 0 0 0 0.08 +- 0.10 3 10

PF00005 (3/3) ABC transporter
PF13646 (2/3) HEAT repeats
PF12838 (2/3) 4Fe-4S dicluster domain
PF09084 (2/3) NMT1/THI5 like
PF07702 (2/3) UTRA domain
PF07228 (2/3) Stage II sporulation protein E (SpoIIE)
PF02910 (2/3) Fumarate reductase flavoprotein C-term
PF00890 (2/3) FAD binding domain
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00392 (2/3) Bacterial regulatory proteins, gntR family

precursor_groups_13335 720.73 +- 236.74 7 0 7 7 0.01 +- 0.01 7 12

TIGR00730 (7/7) TIGR00730 family protein
PF14833 (7/7) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13537 (7/7) Glutamine amidotransferase domain
PF13480 (7/7) Acetyltransferase (GNAT) domain
PF07690 (7/7) Major Facilitator Superfamily
PF03641 (7/7) Possible lysine decarboxylase
PF03446 (7/7) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02709 (7/7) N-terminal domain of galactosyltransferase
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00733 (7/7) Asparagine synthase
PF00535 (7/7) Glycosyl transferase family 2
PF00300 (7/7) Histidine phosphatase superfamily (branch 1)

precursor_groups_42234 236.50 +- 30.41 3 0 0 0 0.01 +- 0.00 3 4

PF13631 (3/3) Cytochrome b(N-terminal)/b6/petB
PF13466 (3/3) STAS domain
PF03861 (3/3) ANTAR domain
PF01590 (3/3) GAF domain

precursor_groups_114 339.00 +- 177.59 7 0 1 0 0.08 +- 0.12 7

No common domains found

precursor_groups_2993 18.33 +- 4.51 2 0 2 0 0.19 +- 0.29 2 15

TIGR00229 (2/2) PAS domain S-box protein
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13581 (2/2) Histidine kinase-like ATPase domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03176 (2/2) MMPL family
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF13426 (1/2) PAS domain
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01590 (1/2) GAF domain
PF00989 (1/2) PAS fold

precursor_groups_26935 275.73 +- 48.75 4 0 0 0 0.03 +- 0.03 4 12

PF13977 (4/4) BetI-type transcriptional repressor, C-terminal
PF13607 (4/4) Succinyl-CoA ligase like flavodoxin domain
PF13549 (4/4) ATP-grasp domain
PF13380 (4/4) CoA binding domain
PF13279 (4/4) Thioesterase-like superfamily
PF07729 (4/4) FCD domain
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00378 (4/4) Enoyl-CoA hydratase/isomerase

precursor_groups_46222 441.12 +- 171.82 3 0 0 0 0.05 +- 0.11 3 6

TIGR03930 (3/3) WXG100 family type VII secretion target
TIGR03921 (3/3) type VII secretion-associated serine protease mycosin
TIGR03919 (3/3) type VII secretion protein EccB
PF06013 (3/3) Proteins of 100 residues with WXG
PF05108 (3/3) Type VII secretion system ESX-1, transport TM domain B
PF00082 (3/3) Subtilase family

precursor_groups_84370 488.69 +- 32.58 2 0 0 0 0.05 +- 0.02 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF07748 (2/2) Glycosyl hydrolases family 38 C-terminal domain
PF04341 (2/2) Protein of unknown function, DUF485
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01381 (2/2) Helix-turn-helix
PF01212 (2/2) Beta-eliminating lyase
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00474 (2/2) Sodium:solute symporter family

precursor_groups_25179 241.43 +- 18.57 2 0 0 2 0.01 +- 0.00 2 9

TIGR04276 (2/2) FxsC C-terminal domain
TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13614 (2/2) AAA domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF04055 (2/2) Radical SAM superfamily
PF02522 (2/2) Aminoglycoside 3-N-acetyltransferase

precursor_groups_13078 1024.31 +- 951.63 6 1 1 4 0.04 +- 0.16 5 19

PF03176 (6/6) MMPL family
PF08241 (5/6) Methyltransferase domain
PF00698 (5/6) Acyl transferase domain
PF00550 (5/6) Phosphopantetheine attachment site
PF00202 (5/6) Aminotransferase class-III
PF00196 (5/6) Bacterial regulatory proteins, luxR family
TIGR03605 (4/6) SagB-type dehydrogenase domain
TIGR03604 (4/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/6) Enoyl-(Acyl carrier protein) reductase
PF07993 (4/6) Male sterility protein
PF03364 (4/6) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/6) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01575 (4/6) MaoC like domain
PF00881 (4/6) Nitroreductase family
PF00109 (4/6) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/6) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/6) MOSC domain
PF00675 (3/6) Insulinase (Peptidase family M16)

precursor_groups_25241 15.83 +- 2.49 3 0 0 0 0.19 +- 0.25 3 6

PF09350 (3/3) Domain of unknown function (DUF1992)
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00072 (3/3) Response regulator receiver domain

precursor_groups_83810 315.24 +- 11.34 2 0 0 0 0.04 +- 0.04 2 14

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16259 (2/2) Domain of unknown function (DUF4913)
PF13535 (2/2) ATP-grasp domain
PF12307 (2/2) Protein of unknown function (DUF3631)
PF08239 (2/2) Bacterial SH3 domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
PF00583 (2/2) Acetyltransferase (GNAT) family
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF17802 (1/2) Prealbumin-like fold domain
PF01555 (1/2) DNA methylase

precursor_groups_83101 199.03 +- 100.12 2 0 0 0 0.17 +- 0.30 2 18

TIGR03177 (2/2) Flp pilus assembly protein CpaB
PF16976 (2/2) Flp pilus assembly protein RcpC/CpaB
PF13614 (2/2) AAA domain
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF07811 (2/2) TadE-like protein
PF07730 (2/2) Histidine kinase
PF00691 (2/2) OmpA family
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF13518 (1/2) Helix-turn-helix domain
PF13401 (1/2) AAA domain
PF09299 (1/2) Mu transposase, C-terminal
PF08722 (1/2) TnsA endonuclease N terminal
PF06527 (1/2) TniQ
PF00665 (1/2) Integrase core domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_2756 20.22 +- 8.95 4 0 0 0 0.16 +- 0.22 4 5

TIGR00099 (2/4) Cof-like hydrolase
PF09335 (2/4) SNARE associated Golgi protein
PF08282 (2/4) haloacid dehalogenase-like hydrolase
PF01522 (2/4) Polysaccharide deacetylase
PF00457 (2/4) Glycosyl hydrolases family 11

precursor_groups_2757 125.00 +- 47.00 2 0 0 0 0.03 +- 0.04 2 5

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_2977 177.87 +- 109.73 22 0 3 0 0.14 +- 0.17 22 6