RiPP-TIDE results

Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_groups_2166 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase
precursor_groups_906 57.96 +- 12.04 2 0 0 2 0.05 +- 0.10 2 9

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily
precursor_groups_239 614.62 +- 470.04 25 0 21 0 0.07 +- 0.11 25 26

TIGR01525 (25/25) heavy metal translocating P-type ATPase
PF04314 (25/25) Copper chaperone PCu(A)C
PF00702 (25/25) haloacid dehalogenase-like hydrolase
PF00403 (25/25) Heavy-metal-associated domain
PF00122 (25/25) E1-E2 ATPase
PF07690 (23/25) Major Facilitator Superfamily
PF05118 (21/25) Aspartyl/Asparaginyl beta-hydroxylase
TIGR01733 (19/25) amino acid adenylation domain
PF13193 (19/25) AMP-binding enzyme C-terminal domain
PF10862 (19/25) FcoT-like thioesterase domain
PF08545 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (19/25) Male sterility protein
PF02668 (19/25) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (19/25) Condensation domain
PF00550 (19/25) Phosphopantetheine attachment site
PF00501 (19/25) AMP-binding enzyme
TIGR01746 (18/25) thioester reductase domain
TIGR00747 (18/25) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01497 (18/25) Periplasmic binding protein
PF01032 (18/25) FecCD transport family
PF00005 (18/25) ABC transporter
PF01965 (17/25) DJ-1/PfpI family
TIGR02937 (16/25) RNA polymerase sigma factor, sigma-70 family
PF08281 (16/25) Sigma-70, region 4
PF04542 (16/25) Sigma-70 region 2
precursor_groups_33088 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_8175 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_groups_8171 414.92 +- 442.96 5 0 0 0 0.06 +- 0.12 5 7

PF13407 (5/5) Periplasmic binding protein domain
PF13377 (5/5) Periplasmic binding protein-like domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00005 (5/5) ABC transporter
PF05025 (4/5) RbsD / FucU transport protein family
precursor_groups_25857 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_groups_48679 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_4581 280.13 +- 235.87 2 0 0 2 0.05 +- 0.16 2 7

PF14518 (2/2) Iron-containing redox enzyme
PF12704 (2/2) MacB-like periplasmic core domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_1662 839.58 +- 460.42 22 20 2 22 0.02 +- 0.02 2 11

TIGR03891 (22/22) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (22/22) Lantibiotic biosynthesis dehydratase C-term
PF05147 (22/22) Lanthionine synthetase C-like protein
PF04738 (22/22) Lantibiotic dehydratase, N terminus
PF00005 (22/22) ABC transporter
TIGR03731 (21/22) lantibiotic, gallidermin/nisin family
PF02052 (18/22) Gallidermin
PF00486 (14/22) Transcriptional regulatory protein, C terminal
PF02518 (12/22) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/22) His Kinase A (phospho-acceptor) domain
PF00072 (12/22) Response regulator receiver domain
precursor_groups_41765 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_groups_31630 43.41 +- 0.41 2 0 2 0 0.07 +- 0.09 2 5

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_81410 1580.73 +- 635.73 2 0 2 0 0.02 +- 0.04 2 14

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
precursor_groups_60000 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_7743 516.00 +- 0.00 2 0 2 2 0.01 +- 0.00 2 7

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_20892 133.48 +- 31.64 2 0 0 0 0.04 +- 0.04 2 6

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
precursor_groups_23858 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain
precursor_groups_4514 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_groups_19376 140.89 +- 0.00 2 0 2 2 0.10 +- 0.08 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_44607 275.37 +- 49.63 2 0 0 0 0.02 +- 0.02 2 8

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16884 (2/2) N-terminal domain of oxidoreductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_46039 398.33 +- 178.68 3 0 0 0 0.02 +- 0.01 3 8

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_6399 79.05 +- 17.93 5 0 0 0 0.08 +- 0.03 5 9

TIGR02133 (5/5) ribose 5-phosphate isomerase
PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (5/5) Major Facilitator Superfamily
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF02734 (5/5) DAK2 domain
PF02733 (5/5) Dak1 domain
PF02502 (5/5) Ribose/Galactose Isomerase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00121 (5/5) Triosephosphate isomerase
precursor_groups_9254 120.00 +- 0.00 2 0 0 0 0.10 +- 0.25 2 12

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold
precursor_groups_62683 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_19562 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat
precursor_groups_2 284.40 +- 250.53 6 0 5 1 0.05 +- 0.12 6 25

PF04149 (5/6) Domain of unknown function (DUF397)
TIGR01762 (4/6) chlorinating enzyme
TIGR01733 (4/6) amino acid adenylation domain
TIGR01509 (4/6) HAD hydrolase, family IA, variant 3
TIGR01444 (4/6) methyltransferase, FkbM family
TIGR00843 (4/6) benzoate transporter
PF16990 (4/6) Carbohydrate binding module (family 35)
PF13560 (4/6) Helix-turn-helix domain
PF13535 (4/6) ATP-grasp domain
PF13454 (4/6) FAD-NAD(P)-binding
PF13419 (4/6) Haloacid dehalogenase-like hydrolase
PF13193 (4/6) AMP-binding enzyme C-terminal domain
PF07691 (4/6) PA14 domain
PF06439 (4/6) Domain of Unknown Function (DUF1080)
PF05721 (4/6) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/6) Methyltransferase FkbM domain
PF03594 (4/6) Benzoate membrane transport protein
PF02771 (4/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/6) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/6) Fructose-bisphosphate aldolase class-II
PF00975 (4/6) Thioesterase domain
PF00892 (4/6) EamA-like transporter family
PF00550 (4/6) Phosphopantetheine attachment site
PF00501 (4/6) AMP-binding enzyme
PF00441 (4/6) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_1 922.65 +- 1480.94 16 0 5 5 0.03 +- 0.05 16 2

PF04149 (16/16) Domain of unknown function (DUF397)
PF13560 (8/16) Helix-turn-helix domain
precursor_groups_6306 257.74 +- 131.52 2 0 0 0 0.02 +- 0.10 2 15

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13560 (1/2) Helix-turn-helix domain
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF01580 (1/2) FtsK/SpoIIIE family
PF00436 (1/2) Single-strand binding protein family
precursor_groups_4 121.60 +- 155.04 4 0 0 0 0.05 +- 0.09 4 6

TIGR01509 (3/4) HAD hydrolase, family IA, variant 3
PF13419 (3/4) Haloacid dehalogenase-like hydrolase
PF08386 (3/4) TAP-like protein
PF04149 (3/4) Domain of unknown function (DUF397)
PF02388 (3/4) FemAB family
PF00561 (3/4) alpha/beta hydrolase fold
precursor_groups_353 456.93 +- 108.77 3 0 3 0 0.03 +- 0.03 3 6

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF01959 (2/3) 3-dehydroquinate synthase II
PF01791 (2/3) DeoC/LacD family aldolase
PF01494 (2/3) FAD binding domain
precursor_groups_11212 795.64 +- 536.08 8 0 8 8 0.03 +- 0.08 8 12

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_groups_31252 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
precursor_groups_3707 1270.23 +- 755.78 18 2 16 18 0.02 +- 0.03 16 8

TIGR03897 (18/18) type 2 lantibiotic biosynthesis protein LanM
PF13575 (18/18) Domain of unknown function (DUF4135)
PF05147 (18/18) Lanthionine synthetase C-like protein
PF03412 (18/18) Peptidase C39 family
PF00664 (18/18) ABC transporter transmembrane region
PF00005 (18/18) ABC transporter
PF14867 (16/18) Lantibiotic alpha
PF12730 (15/18) ABC-2 family transporter protein
precursor_groups_46517 138.46 +- 43.67 3 0 0 0 0.03 +- 0.02 3 9

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_41235 63.35 +- 11.31 3 0 0 0 0.05 +- 0.03 3 4

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_17587 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_groups_121 1363.95 +- 1630.95 4 0 4 4 0.04 +- 0.08 4 14

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF03704 (4/4) Bacterial transcriptional activator domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (4/4) ABC-2 type transporter
PF00881 (4/4) Nitroreductase family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00005 (4/4) ABC transporter
TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor
TIGR01891 (3/4) amidohydrolase
PF01546 (3/4) Peptidase family M20/M25/M40
PF00296 (2/4) Luciferase-like monooxygenase
precursor_groups_34009 377.27 +- 142.73 2 0 0 0 0.02 +- 0.01 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_groups_21556 832.00 +- 254.75 5 0 0 5 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02441 (5/5) Flavoprotein
precursor_groups_18390 864.29 +- 155.78 3 0 3 3 0.01 +- 0.02 3 9

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_44042 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_groups_71616 195.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_61212 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_groups_3209 61.10 +- 12.21 3 0 1 0 0.05 +- 0.02 3 3

PF01292 (3/3) Prokaryotic cytochrome b561
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF07519 (2/3) Tannase and feruloyl esterase
precursor_groups_55307 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V
precursor_groups_83750 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_41801 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_36866 332.14 +- 118.84 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family
precursor_groups_545 287.08 +- 232.92 2 0 2 2 0.04 +- 0.10 2 7

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_groups_542 156.12 +- 66.54 2 0 1 0 0.07 +- 0.06 2 10

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03814 (1/2) Potassium-transporting ATPase A subunit
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01433 (1/2) Peptidase family M1 domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10
PF00293 (1/2) NUDIX domain
precursor_groups_11589 780.00 +- 260.00 6 0 0 6 0.01 +- 0.00 6 4

PF07690 (6/6) Major Facilitator Superfamily
PF04055 (6/6) Radical SAM superfamily
PF02441 (6/6) Flavoprotein
PF02310 (3/6) B12 binding domain
precursor_groups_11233 4608.81 +- 2021.19 2 0 2 0 0.02 +- 0.03 2 16

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain
precursor_groups_104 219.64 +- 53.64 11 0 0 0 0.04 +- 0.06 11 3

PF13545 (9/11) Crp-like helix-turn-helix domain
PF07228 (9/11) Stage II sporulation protein E (SpoIIE)
PF00027 (9/11) Cyclic nucleotide-binding domain
precursor_groups_4868 229.23 +- 30.77 3 1 1 0 0.01 +- 0.01 2 4

PF03412 (3/3) Peptidase C39 family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF00535 (2/3) Glycosyl transferase family 2
precursor_groups_17449 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_68315 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_70666 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_groups_23434 338.00 +- 182.00 2 0 0 0 0.02 +- 0.06 2 10

PF07291 (2/2) Methylamine utilisation protein MauE
PF00717 (2/2) Peptidase S24-like
PF00005 (2/2) ABC transporter
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10502 (1/2) Signal peptidase, peptidase S26
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (1/2) FAD binding domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00578 (1/2) AhpC/TSA family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_11906 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_groups_78352 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_20733 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
precursor_groups_77605 230.67 +- 116.00 2 0 0 0 0.02 +- 0.03 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_35663 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
precursor_groups_15437 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family
precursor_groups_2281 800.06 +- 256.65 6 0 5 0 0.01 +- 0.01 6 11

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_groups_10508 299.00 +- 23.50 2 0 0 0 0.05 +- 0.09 2 12

TIGR01764 (2/2) DNA binding domain, excisionase family
PF13411 (2/2) MerR HTH family regulatory protein
PF13245 (2/2) AAA domain
PF12728 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF12679 (2/2) ABC-2 family transporter protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF01551 (2/2) Peptidase family M23
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_groups_5419 953.88 +- 214.88 4 0 0 4 0.01 +- 0.01 4 7

TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
precursor_groups_23648 167.66 +- 10.77 2 0 0 0 0.06 +- 0.03 2 9

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_765 190.01 +- 103.85 17 0 17 16 0.04 +- 0.06 17 5

TIGR03975 (17/17) ribosomal peptide maturation radical SAM protein 1
PF07690 (17/17) Major Facilitator Superfamily
PF02310 (17/17) B12 binding domain
PF00326 (17/17) Prolyl oligopeptidase family
PF04055 (16/17) Radical SAM superfamily
precursor_groups_75057 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_1137 203.30 +- 256.64 4 0 0 0 0.04 +- 0.05 4 2

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase
precursor_groups_45170 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_groups_40558 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_groups_24923 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_20597 400.13 +- 221.16 3 0 1 0 0.05 +- 0.17 3 26

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain
precursor_groups_22333 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6
precursor_groups_12158 2061.33 +- 765.80 7 0 0 0 0.01 +- 0.01 7 12

PF17874 (7/7) MalT-like TPR region
PF13560 (7/7) Helix-turn-helix domain
PF13393 (7/7) Histidyl-tRNA synthetase
PF05193 (7/7) Peptidase M16 inactive domain
PF03721 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (7/7) GlcNAc-PI de-N-acetylase
PF01370 (7/7) NAD dependent epimerase/dehydratase family
PF01061 (7/7) ABC-2 type transporter
PF00984 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (7/7) Insulinase (Peptidase family M16)
PF00005 (7/7) ABC transporter
precursor_groups_61591 306.43 +- 83.57 2 0 2 0 0.01 +- 0.00 2 7

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_6342 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_1450 759.98 +- 690.09 3 0 3 3 0.06 +- 0.20 3 6

PF06114 (3/3) IrrE N-terminal-like domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
precursor_groups_14823 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_groups_1355 178.94 +- 79.06 2 0 0 0 0.04 +- 0.07 2 5

PF00067 (2/2) Cytochrome P450
PF14534 (1/2) Domain of unknown function (DUF4440)
PF08002 (1/2) Protein of unknown function (DUF1697)
PF05922 (1/2) Peptidase inhibitor I9
PF00082 (1/2) Subtilase family
precursor_groups_45774 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_73507 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_groups_9108 117.34 +- 48.52 2 0 2 0 0.03 +- 0.04 2 4

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_64153 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter
precursor_groups_84823 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_78012 710.45 +- 47.26 2 0 2 2 0.03 +- 0.03 2 20

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
precursor_groups_6043 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_70686 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_71289 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
precursor_groups_1957 91.17 +- 58.33 18 0 0 0 0.03 +- 0.02 18 3

PF12833 (18/18) Helix-turn-helix domain
PF02311 (18/18) AraC-like ligand binding domain
PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)
precursor_groups_165 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_5606 65.80 +- 23.86 2 0 1 0 0.05 +- 0.06 2 8

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (1/2) Glycosyl hydrolase family 92
precursor_groups_79714 2072.00 +- 8.00 2 0 0 0 0.01 +- 0.00 2 7

PF08386 (2/2) TAP-like protein
PF07702 (2/2) UTRA domain
PF01380 (2/2) SIS domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_17666 49.71 +- 15.29 2 0 2 2 0.07 +- 0.08 2 6

PF14518 (2/2) Iron-containing redox enzyme
PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (2/2) Subtilase family
precursor_groups_1821 358.75 +- 32.16 2 0 0 0 0.01 +- 0.01 2 18

TIGR01558 (2/2) putative phage terminase, small subunit, P27 family
TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/2) Phage-related minor tail protein
PF05119 (2/2) Phage terminase, small subunit
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04586 (2/2) Caudovirus prohead serine protease
PF04542 (2/2) Sigma-70 region 2
PF03354 (2/2) Phage Terminase
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (2/2) Collagen triple helix repeat (20 copies)
PF01381 (2/2) Helix-turn-helix
PF00271 (2/2) Helicase conserved C-terminal domain
precursor_groups_68266 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_463 130.00 +- 70.00 2 0 0 0 0.04 +- 0.03 2 6

PF12833 (2/2) Helix-turn-helix domain
PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/2) mttA/Hcf106 family
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
precursor_groups_462 509.83 +- 454.74 34 0 18 1 0.05 +- 0.15 34 15

TIGR01850 (34/34) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (34/34) RimK-like ATP-grasp domain
PF02779 (34/34) Transketolase, pyrimidine binding domain
PF01118 (34/34) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (34/34) Transketolase, thiamine diphosphate binding domain
TIGR00768 (30/34) alpha-L-glutamate ligase, RimK family
TIGR01902 (23/34) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (23/34) Peptidase family M20/M25/M40
PF01041 (23/34) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (23/34) Amino acid kinase family
PF07690 (18/34) Major Facilitator Superfamily
PF18603 (17/34) L-amino acid ligase C-terminal domain 2
PF18130 (17/34) ATP-grasp N-terminal domain
PF13535 (17/34) ATP-grasp domain
PF02780 (17/34) Transketolase, C-terminal domain
precursor_groups_9061 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_500 726.73 +- 607.66 2 0 1 1 0.08 +- 0.19 2 21

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/2) amidohydrolase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (1/2) Histidine kinase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03412 (1/2) Peptidase C39 family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (1/2) Peptidase family M20/M25/M40
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00877 (1/2) NlpC/P60 family
PF00664 (1/2) ABC transporter transmembrane region
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
precursor_groups_265 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_44077 763.96 +- 609.16 2 0 2 1 0.05 +- 0.14 2 24

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
precursor_groups_41937 915.56 +- 502.62 2 0 0 0 0.01 +- 0.01 2 8

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_22977 3011.04 +- 331.81 2 0 2 2 0.01 +- 0.01 2 8

PF13649 (2/2) Methyltransferase domain
PF12730 (2/2) ABC-2 family transporter protein
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter
precursor_groups_4638 1058.04 +- 888.53 15 0 12 0 0.05 +- 0.18 15 18

TIGR01307 (15/15) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13535 (15/15) ATP-grasp domain
PF13480 (15/15) Acetyltransferase (GNAT) domain
PF13115 (15/15) YtkA-like
PF04389 (15/15) Peptidase family M28
PF02627 (15/15) Carboxymuconolactone decarboxylase family
PF01676 (15/15) Metalloenzyme superfamily
PF00664 (15/15) ABC transporter transmembrane region
PF00403 (15/15) Heavy-metal-associated domain
PF00275 (15/15) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (15/15) Aminotransferase class I and II
PF00117 (15/15) Glutamine amidotransferase class-I
PF00005 (15/15) ABC transporter
TIGR01525 (14/15) heavy metal translocating P-type ATPase
TIGR01356 (14/15) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13549 (14/15) ATP-grasp domain
PF00702 (14/15) haloacid dehalogenase-like hydrolase
PF00122 (14/15) E1-E2 ATPase
precursor_groups_15205 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
precursor_groups_62121 151.58 +- 28.42 2 0 0 0 0.02 +- 0.02 2 3

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_62573 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_53738 2291.55 +- 1062.45 2 0 0 0 0.01 +- 0.01 2 14

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF12146 (2/2) Serine aminopeptidase, S33
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (2/2) GH3 auxin-responsive promoter
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)
precursor_groups_28574 274.58 +- 189.71 2 0 2 0 0.03 +- 0.05 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_2083 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_20660 144.72 +- 11.28 2 0 2 2 0.04 +- 0.04 2 3

PF13471 (2/2) Transglutaminase-like superfamily
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase
precursor_groups_1011 122.11 +- 96.49 3 0 0 0 0.03 +- 0.04 3 5

TIGR01840 (3/3) esterase, PHB depolymerase family
TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (3/3) Protein of unknown function (DUF4232)
PF10503 (3/3) Esterase PHB depolymerase
PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_groups_58650 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_groups_5459 235.19 +- 41.40 6 0 1 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (6/6) YbaB/EbfC DNA-binding family
precursor_groups_32866 197.39 +- 31.14 3 0 0 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_groups_10155 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_28226 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_groups_85472 390.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_918 213.47 +- 171.99 14 0 12 14 0.02 +- 0.02 14 4

PF04055 (14/14) Radical SAM superfamily
PF07690 (13/14) Major Facilitator Superfamily
PF02897 (12/14) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (12/14) Prolyl oligopeptidase family
precursor_groups_28782 253.73 +- 93.57 2 0 0 0 0.05 +- 0.06 2 11

PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_15497 1363.59 +- 571.41 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_20405 235.76 +- 54.49 2 0 0 0 0.08 +- 0.12 2 11

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (2/2) Domain of unknown function (DUF4331)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00925 (2/2) GTP cyclohydrolase II
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00082 (2/2) Subtilase family
precursor_groups_37629 453.70 +- 99.16 2 0 0 0 0.03 +- 0.02 2 7

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
precursor_groups_1673 545.07 +- 292.47 24 0 24 24 0.04 +- 0.09 24 6

PF05147 (24/24) Lanthionine synthetase C-like protein
PF00664 (24/24) ABC transporter transmembrane region
PF00326 (24/24) Prolyl oligopeptidase family
PF00069 (24/24) Protein kinase domain
PF00005 (24/24) ABC transporter
PF04672 (23/24) S-adenosyl methyltransferase
precursor_groups_20705 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_72197 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_45090 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_groups_8543 47.10 +- 5.79 3 0 0 0 0.06 +- 0.05 3 5

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (3/3) SCP-2 sterol transfer family
precursor_groups_10436 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_42674 291.05 +- 29.25 2 0 0 0 0.08 +- 0.18 2 21

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF12831 (2/2) FAD dependent oxidoreductase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (2/2) CoA-transferase family III
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01381 (2/2) Helix-turn-helix
PF01380 (2/2) SIS domain
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_groups_84552 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
precursor_groups_21947 420.25 +- 97.76 4 0 4 0 0.01 +- 0.00 4 6

PF03412 (4/4) Peptidase C39 family
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter
precursor_groups_14303 191.56 +- 72.66 4 0 0 0 0.07 +- 0.11 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_1009 1097.05 +- 1032.42 46 7 39 45 0.03 +- 0.09 39 7

PF13575 (45/46) Domain of unknown function (DUF4135)
PF05147 (45/46) Lanthionine synthetase C-like protein
TIGR03897 (44/46) type 2 lantibiotic biosynthesis protein LanM
PF03412 (44/46) Peptidase C39 family
PF00664 (44/46) ABC transporter transmembrane region
PF00005 (44/46) ABC transporter
PF14867 (43/46) Lantibiotic alpha
precursor_groups_48611 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_16355 383.81 +- 168.05 5 0 0 5 0.01 +- 0.03 5 7

TIGR00702 (5/5) YcaO-type kinase domain
PF18029 (5/5) Glyoxalase-like domain
PF13489 (5/5) Methyltransferase domain
PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (5/5) TfuA-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_40542 328.15 +- 104.38 2 0 2 0 0.07 +- 0.16 2 15

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
precursor_groups_76415 96.37 +- 5.37 2 0 0 0 0.03 +- 0.04 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_42 40.24 +- 11.75 3 0 0 0 0.08 +- 0.17 3 3

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C
precursor_groups_42811 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_groups_49 249.44 +- 156.55 16 8 7 10 0.05 +- 0.06 8 4

PF00005 (16/16) ABC transporter
PF00664 (14/16) ABC transporter transmembrane region
PF00069 (13/16) Protein kinase domain
PF05147 (9/16) Lanthionine synthetase C-like protein
precursor_groups_80550 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region
precursor_groups_51837 1068.75 +- 101.25 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_50833 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_15659 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
precursor_groups_321 32.76 +- 4.10 2 0 0 0 0.06 +- 0.03 2 2

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_6316 468.39 +- 239.31 3 0 0 0 0.03 +- 0.02 3 14

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF01494 (3/3) FAD binding domain
PF00561 (3/3) alpha/beta hydrolase fold
TIGR00928 (2/3) adenylosuccinate lyase
PF13673 (2/3) Acetyltransferase (GNAT) domain
PF12800 (2/3) 4Fe-4S binding domain
PF01425 (2/3) Amidase
PF00486 (2/3) Transcriptional regulatory protein, C terminal
PF00206 (2/3) Lyase
PF00120 (2/3) Glutamine synthetase, catalytic domain
PF00072 (2/3) Response regulator receiver domain
precursor_groups_82367 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_5888 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_groups_733 5756.47 +- 1500.30 3 0 3 3 0.01 +- 0.01 3 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00005 (3/3) ABC transporter
TIGR01189 (2/3) heme ABC exporter, ATP-binding protein CcmA
PF12698 (2/3) ABC-2 family transporter protein
precursor_groups_730 1147.46 +- 656.81 23 5 18 23 0.02 +- 0.04 18 8

TIGR03897 (23/23) type 2 lantibiotic biosynthesis protein LanM
PF13575 (23/23) Domain of unknown function (DUF4135)
PF05147 (23/23) Lanthionine synthetase C-like protein
PF03412 (22/23) Peptidase C39 family
PF00664 (22/23) ABC transporter transmembrane region
PF00005 (22/23) ABC transporter
TIGR03898 (20/23) type 2 lantibiotic, mersacidin/lichenicidin family
PF12679 (14/23) ABC-2 family transporter protein
precursor_groups_83733 4608.81 +- 2021.19 2 0 2 0 0.02 +- 0.03 2 16

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain
precursor_groups_2450 27.06 +- 5.19 2 0 0 0 0.09 +- 0.10 2 7

PF13516 (2/2) Leucine Rich repeat
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF14435 (1/2) SUKH-4 immunity protein
PF12796 (1/2) Ankyrin repeats (3 copies)
PF01738 (1/2) Dienelactone hydrolase family
precursor_groups_46115 186.14 +- 8.86 2 0 0 0 0.03 +- 0.04 2 6

PF13564 (2/2) DoxX-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (2/2) NADPH-dependent FMN reductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF18616 (1/2) CDI immunity proteins
precursor_groups_2515 339.13 +- 0.00 2 0 0 0 0.03 +- 0.01 2 8

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_81827 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_9139 7843.20 +- 6508.80 2 0 2 2 0.05 +- 0.15 2 21

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_groups_14447 122.10 +- 43.38 4 0 0 0 0.05 +- 0.04 4 12

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_429 687.94 +- 313.54 3 1 2 3 0.02 +- 0.02 2 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00069 (3/3) Protein kinase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00494 (2/3) Squalene/phytoene synthase
precursor_groups_32192 365.31 +- 284.69 2 0 0 0 0.03 +- 0.05 2 3

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase
precursor_groups_427 3858.25 +- 1997.49 19 0 19 19 0.02 +- 0.06 19 7

TIGR03882 (19/19) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (19/19) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (19/19) Lantibiotic biosynthesis dehydratase C-term
PF02624 (19/19) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (19/19) Nitroreductase family
PF00005 (13/19) ABC transporter
PF05402 (10/19) Coenzyme PQQ synthesis protein D (PqqD)
precursor_groups_12981 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
precursor_groups_132 112.76 +- 103.65 3 0 0 0 0.05 +- 0.07 3

No common domains found
precursor_groups_67117 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_48975 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family
precursor_groups_42689 1292.60 +- 296.28 2 0 2 2 0.03 +- 0.02 2 9

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (2/2) Lantibiotic alpha
PF13575 (2/2) Domain of unknown function (DUF4135)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
precursor_groups_45864 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_5499 174.02 +- 47.17 5 0 0 0 0.07 +- 0.10 5 7

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF12680 (5/5) SnoaL-like domain
PF07045 (5/5) Domain of unknown function (DUF1330)
PF01738 (5/5) Dienelactone hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter
precursor_groups_26684 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_groups_54637 69.96 +- 24.43 2 0 0 2 0.05 +- 0.09 2 11

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain
precursor_groups_12804 206.28 +- 77.96 4 0 0 0 0.09 +- 0.09 4 17

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (4/4) Alpha galactosidase A
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
precursor_groups_56365 433.58 +- 275.92 2 0 0 0 0.04 +- 0.03 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_groups_556 112.93 +- 162.01 47 4 40 47 0.04 +- 0.07 43 3

PF00733 (47/47) Asparagine synthase
PF13471 (46/47) Transglutaminase-like superfamily
PF05402 (46/47) Coenzyme PQQ synthesis protein D (PqqD)
precursor_groups_6671 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_13764 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family
precursor_groups_12543 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_5653 964.27 +- 325.73 2 0 0 0 0.01 +- 0.02 2 12

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_75740 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_groups_819 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_groups_50706 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
precursor_groups_62248 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_19855 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_64908 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
precursor_groups_10742 114.31 +- 18.14 2 0 0 0 0.08 +- 0.04 2 5

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00266 (2/2) Aminotransferase class-V
precursor_groups_2334 222.67 +- 78.34 11 0 0 0 0.03 +- 0.02 11 10

TIGR03930 (11/11) WXG100 family type VII secretion target
TIGR03920 (11/11) type VII secretion integral membrane protein EccD
TIGR03919 (11/11) type VII secretion protein EccB
PF15644 (11/11) Papain fold toxin 1, glutamine deamidase
PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD
PF07179 (11/11) SseB protein N-terminal domain
PF06013 (11/11) Proteins of 100 residues with WXG
PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B
PF02575 (11/11) YbaB/EbfC DNA-binding family
PF00652 (11/11) Ricin-type beta-trefoil lectin domain
precursor_groups_1282 192.97 +- 127.67 14 0 14 14 0.05 +- 0.03 14 13

TIGR04451 (14/14) lantipeptide, SCO0268 family
TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF05147 (14/14) Lanthionine synthetase C-like protein
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF12802 (9/14) MarR family
PF12697 (9/14) Alpha/beta hydrolase family
PF02065 (9/14) Melibiase
PF01547 (9/14) Bacterial extracellular solute-binding protein
PF00528 (9/14) Binding-protein-dependent transport system inner membrane component
PF00480 (9/14) ROK family
PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_29741 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
precursor_groups_1446 48.54 +- 0.65 2 0 0 0 0.08 +- 0.17 2 3

TIGR03296 (2/2) M6 family metalloprotease domain
PF09339 (2/2) IclR helix-turn-helix domain
PF03777 (2/2) ChpA-C
precursor_groups_21578 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_15041 226.53 +- 46.37 3 0 0 0 0.07 +- 0.11 3 11

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14224 (3/3) Domain of unknown function (DUF4331)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00925 (3/3) GTP cyclohydrolase II
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00082 (3/3) Subtilase family
PF02882 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_50390 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_15049 2401.56 +- 1135.16 3 0 0 0 0.02 +- 0.01 3 13

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (3/3) ATP-grasp domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01613 (3/3) Flavin reductase like domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00106 (3/3) short chain dehydrogenase
PF18130 (2/3) ATP-grasp N-terminal domain
precursor_groups_52507 134.01 +- 78.72 2 0 2 2 0.06 +- 0.05 2 9

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat
precursor_groups_9354 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_64010 117.00 +- 13.00 2 0 2 0 0.02 +- 0.01 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_36155 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
precursor_groups_72354 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_groups_2029 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_10969 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_39 50.96 +- 24.18 3 0 0 0 0.05 +- 0.03 3 3

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_585 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_1347 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_14643 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_6914 73.12 +- 24.38 2 0 0 0 0.03 +- 0.02 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein
precursor_groups_10887 157.25 +- 62.23 4 0 2 0 0.07 +- 0.19 4 9

PF13191 (4/4) AAA ATPase domain
PF10502 (4/4) Signal peptidase, peptidase S26
PF07291 (4/4) Methylamine utilisation protein MauE
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
PF02254 (3/4) TrkA-N domain
PF01242 (3/4) 6-pyruvoyl tetrahydropterin synthase
PF00664 (3/4) ABC transporter transmembrane region
PF13181 (2/4) Tetratricopeptide repeat
precursor_groups_9177 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_52435 1163.94 +- 693.66 2 0 0 0 0.02 +- 0.01 2 18

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_20284 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_groups_12012 858.49 +- 193.39 4 0 4 4 0.01 +- 0.00 4 11

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
precursor_groups_68571 24.72 +- 1.08 2 0 0 0 0.08 +- 0.08 2 4

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
precursor_groups_1193 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like
precursor_groups_68779 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_22154 1767.52 +- 216.09 3 0 1 3 0.01 +- 0.02 3 10

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family
precursor_groups_170 250.91 +- 0.64 2 0 1 0 0.07 +- 0.08 2 42

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR02258 (1/2) 2'-5' RNA ligase
TIGR00517 (1/2) acyl carrier protein
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13377 (1/2) Periplasmic binding protein-like domain
PF08386 (1/2) TAP-like protein
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07555 (1/2) beta-N-acetylglucosaminidase
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02838 (1/2) Glycosyl hydrolase family 20, domain 2
PF02834 (1/2) LigT like Phosphoesterase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01381 (1/2) Helix-turn-helix
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00668 (1/2) Condensation domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_174 500.84 +- 250.71 5 0 5 5 0.02 +- 0.05 5 11

TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM
PF13575 (5/5) Domain of unknown function (DUF4135)
PF13191 (5/5) AAA ATPase domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF00931 (5/5) NB-ARC domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13185 (4/5) GAF domain
PF08448 (4/5) PAS fold
PF07228 (4/5) Stage II sporulation protein E (SpoIIE)
precursor_groups_21393 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain
precursor_groups_10707 221.77 +- 79.53 9 0 0 0 0.05 +- 0.04 9 10

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_groups_48835 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_5265 2176.88 +- 2360.36 4 0 4 4 0.01 +- 0.01 4 8

TIGR03897 (4/4) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/4) Lantibiotic alpha
PF13575 (4/4) Domain of unknown function (DUF4135)
PF05147 (4/4) Lanthionine synthetase C-like protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF00296 (3/4) Luciferase-like monooxygenase
precursor_groups_2240 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_2244 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix
precursor_groups_19605 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_groups_450 27.25 +- 2.74 9 0 3 0 0.07 +- 0.09 9 6

PF13244 (9/9) Domain of unknown function (DUF4040)
PF12840 (9/9) Helix-turn-helix domain
PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (9/9) Proton-conducting membrane transporter
precursor_groups_43009 109.51 +- 1.92 2 0 0 0 0.04 +- 0.03 2 6

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family
precursor_groups_108 126.20 +- 2.80 2 0 1 0 0.05 +- 0.05 2 16

PF13088 (2/2) BNR repeat-like domain
TIGR03444 (1/2) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13641 (1/2) Glycosyltransferase like family 2
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13520 (1/2) Amino acid permease
PF11695 (1/2) Domain of unknown function (DUF3291)
PF04978 (1/2) Protein of unknown function (DUF664)
PF04264 (1/2) YceI-like domain
PF04248 (1/2) Domain of unknown function (DUF427)
PF04237 (1/2) YjbR
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_6137 726.94 +- 148.59 6 0 0 0 0.02 +- 0.02 6 7

PF17914 (6/6) HopA1 effector protein family
PF13649 (6/6) Methyltransferase domain
PF05193 (6/6) Peptidase M16 inactive domain
PF02441 (6/6) Flavoprotein
PF00675 (6/6) Insulinase (Peptidase family M16)
PF00296 (6/6) Luciferase-like monooxygenase
PF00005 (6/6) ABC transporter
precursor_groups_513 297.75 +- 125.22 3 0 0 3 0.02 +- 0.03 3 10

TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF12706 (3/3) Beta-lactamase superfamily domain
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
precursor_groups_31875 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_100 634.11 +- 416.96 8 0 5 8 0.05 +- 0.08 8 21

TIGR04364 (8/8) methyltransferase, FxLD system
TIGR04363 (8/8) FxLD family lantipeptide
TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term
PF05147 (8/8) Lanthionine synthetase C-like protein
PF04738 (8/8) Lantibiotic dehydratase, N terminus
PF01135 (8/8) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF05331 (7/8) Protein of unknown function (DUF742)
PF03259 (7/8) Roadblock/LC7 domain
PF03029 (7/8) Conserved hypothetical ATP binding protein
PF01427 (7/8) D-ala-D-ala dipeptidase
PF00293 (7/8) NUDIX domain
PF00196 (7/8) Bacterial regulatory proteins, luxR family
PF00005 (7/8) ABC transporter
PF02771 (5/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/8) Acyl-CoA dehydrogenase, middle domain
PF01590 (5/8) GAF domain
PF00723 (5/8) Glycosyl hydrolases family 15
PF00441 (5/8) Acyl-CoA dehydrogenase, C-terminal domain
PF13671 (4/8) AAA domain
PF02518 (4/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_22572 473.90 +- 383.28 4 0 4 0 0.06 +- 0.20 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13632 (4/4) Glycosyl transferase family group 2
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13191 (4/4) AAA ATPase domain
PF12710 (4/4) haloacid dehalogenase-like hydrolase
PF07690 (4/4) Major Facilitator Superfamily
PF04321 (4/4) RmlD substrate binding domain
PF01979 (4/4) Amidohydrolase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00459 (4/4) Inositol monophosphatase family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
TIGR00178 (3/4) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/4) Monomeric isocitrate dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_1833 328.63 +- 21.56 3 0 3 3 0.03 +- 0.03 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF01546 (3/3) Peptidase family M20/M25/M40
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter
precursor_groups_298 359.72 +- 141.51 6 0 0 0 0.02 +- 0.04 6 6

PF07739 (6/6) TipAS antibiotic-recognition domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF13411 (5/6) MerR HTH family regulatory protein
PF01551 (5/6) Peptidase family M23
precursor_groups_3023 325.00 +- 239.00 3 0 0 0 0.03 +- 0.08 3 3

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family
precursor_groups_295 1775.87 +- 1261.12 4 0 3 4 0.04 +- 0.14 4 8

PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein
precursor_groups_26658 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
precursor_groups_67341 447.87 +- 22.41 2 0 0 0 0.04 +- 0.02 2 16

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_5466 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_84495 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_groups_84497 4695.60 +- 0.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12698 (2/2) ABC-2 family transporter protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
precursor_groups_58293 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_groups_2742 187.56 +- 79.93 4 0 0 0 0.03 +- 0.04 4 5

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
precursor_groups_48573 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_65596 175.06 +- 37.41 2 0 0 0 0.03 +- 0.04 2 9

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_11811 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_groups_68952 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_groups_7713 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_groups_14797 47.52 +- 9.22 3 0 0 0 0.04 +- 0.05 3 3

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_69133 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
precursor_groups_11727 272.98 +- 0.99 3 0 3 0 0.09 +- 0.18 3 11

TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF05013 (3/3) N-formylglutamate amidohydrolase
PF03412 (3/3) Peptidase C39 family
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF00664 (3/3) ABC transporter transmembrane region
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00005 (3/3) ABC transporter
PF13437 (2/3) HlyD family secretion protein
precursor_groups_73777 149.12 +- 39.59 2 0 0 0 0.06 +- 0.02 2 7

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_49943 347.93 +- 153.74 2 0 2 2 0.05 +- 0.08 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_639 398.21 +- 55.58 6 0 6 6 0.07 +- 0.08 6 12

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (6/6) SagB-type dehydrogenase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13191 (6/6) AAA ATPase domain
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF03704 (6/6) Bacterial transcriptional activator domain
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (6/6) ABC-2 type transporter
PF00881 (6/6) Nitroreductase family
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00005 (6/6) ABC transporter
precursor_groups_12109 150.50 +- 136.83 4 0 0 0 0.03 +- 0.02 4 3

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)
precursor_groups_61909 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_35315 582.00 +- 192.00 2 0 0 0 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_groups_25675 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_9823 404.91 +- 183.77 2 0 0 2 0.07 +- 0.11 2 18

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
TIGR01249 (1/2) prolyl aminopeptidase
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF04203 (1/2) Sortase domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01610 (1/2) Transposase
PF01381 (1/2) Helix-turn-helix
PF00672 (1/2) HAMP domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00561 (1/2) alpha/beta hydrolase fold
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00400 (1/2) WD domain, G-beta repeat
PF00072 (1/2) Response regulator receiver domain
precursor_groups_84405 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_23621 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
precursor_groups_4069 27.10 +- 6.92 3 0 0 0 0.08 +- 0.07 3 3

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_52985 91.60 +- 0.33 2 0 2 0 0.10 +- 0.29 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_groups_1547 2852.98 +- 1813.19 13 8 5 13 0.01 +- 0.01 5 9

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/13) Nitroreductase family
TIGR03605 (11/13) SagB-type dehydrogenase domain
PF04738 (10/13) Lantibiotic dehydratase, N terminus
PF00067 (8/13) Cytochrome P450
PF00440 (7/13) Bacterial regulatory proteins, tetR family
precursor_groups_16719 137.60 +- 68.80 2 0 0 0 0.06 +- 0.05 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_52076 139.98 +- 39.33 2 0 0 0 0.04 +- 0.04 2 6

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_50588 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_71689 344.00 +- 0.00 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
precursor_groups_74379 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_groups_63001 105.74 +- 24.26 2 0 0 0 0.03 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_1380 744.35 +- 495.10 3 0 2 3 0.02 +- 0.02 3 25

TIGR04504 (3/3) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (3/3) mycofactocin precursor
TIGR03967 (3/3) putative mycofactocin binding protein MftB
TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (3/3) mycofactocin system glycosyltransferase
TIGR03964 (3/3) mycofactocin system creatininase family protein
TIGR03962 (3/3) mycofactocin radical SAM maturase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF04055 (3/3) Radical SAM superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
PF17676 (2/3) LD-carboxypeptidase C-terminal domain
PF16861 (2/3) Carbamoyltransferase C-terminus
PF13489 (2/3) Methyltransferase domain
PF08242 (2/3) Methyltransferase domain
PF03129 (2/3) Anticodon binding domain
PF02543 (2/3) Carbamoyltransferase N-terminus
PF02016 (2/3) LD-carboxypeptidase N-terminal domain
PF01980 (2/3) tRNA-methyltransferase O
PF01041 (2/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00152 (2/3) tRNA synthetases class II (D, K and N)
PF00067 (2/3) Cytochrome P450
precursor_groups_25018 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450
precursor_groups_6246 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
precursor_groups_20824 1582.13 +- 391.36 2 0 2 0 0.03 +- 0.04 2 28

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10862 (2/2) FcoT-like thioesterase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (2/2) Sigma-70, region 4
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03929 (2/2) PepSY-associated TM region
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (2/2) DJ-1/PfpI family
PF01794 (2/2) Ferric reductase like transmembrane component
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter
precursor_groups_10459 128.12 +- 45.26 4 0 4 0 0.08 +- 0.18 4 20

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (4/4) Thioesterase domain
PF00877 (4/4) NlpC/P60 family
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12158 (2/4) Protein of unknown function (DUF3592)
PF01145 (2/4) SPFH domain / Band 7 family
precursor_groups_22684 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
precursor_groups_37828 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_groups_5898 203.13 +- 221.37 6 0 4 0 0.05 +- 0.10 6 6

PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (6/6) BFD-like [2Fe-2S] binding domain
PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (6/6) FAD dependent oxidoreductase
PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (4/6) NUDIX domain
precursor_groups_25793 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_groups_76314 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_groups_25791 685.57 +- 53.59 4 0 3 0 0.07 +- 0.22 4 19

TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (4/4) ATP-grasp domain
PF13535 (4/4) ATP-grasp domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF13115 (4/4) YtkA-like
PF04389 (4/4) Peptidase family M28
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01676 (4/4) Metalloenzyme superfamily
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00664 (4/4) ABC transporter transmembrane region
PF00403 (4/4) Heavy-metal-associated domain
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (4/4) Aminotransferase class I and II
PF00122 (4/4) E1-E2 ATPase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00005 (4/4) ABC transporter
PF02222 (2/4) ATP-grasp domain
precursor_groups_63090 237.03 +- 98.37 2 0 0 0 0.02 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_83681 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase
precursor_groups_56850 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_6965 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_9048 119.08 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_groups_46472 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
precursor_groups_2839 56.37 +- 16.27 3 0 0 0 0.08 +- 0.07 3 4

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (3/3) Major Facilitator Superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00106 (3/3) short chain dehydrogenase
precursor_groups_10786 234.57 +- 34.56 3 0 0 0 0.01 +- 0.00 3 4

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03713 (3/3) Domain of unknown function (DUF305)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
precursor_groups_72732 461.05 +- 11.67 2 0 0 0 0.04 +- 0.01 2 17

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
precursor_groups_3163 322.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 7

PF17964 (1/2) Bacterial Ig domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF04672 (1/2) S-adenosyl methyltransferase
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_2844 37.67 +- 9.91 8 0 0 0 0.06 +- 0.08 8 5

PF17866 (8/8) AAA lid domain
PF13229 (8/8) Right handed beta helix region
PF00652 (8/8) Ricin-type beta-trefoil lectin domain
PF00082 (8/8) Subtilase family
PF00004 (8/8) ATPase family associated with various cellular activities (AAA)
precursor_groups_50774 1057.64 +- 490.36 2 0 2 2 0.01 +- 0.02 2 9

TIGR04353 (2/2) PqqD family protein, HPr-rel-A system
PF13646 (2/2) HEAT repeats
PF13471 (2/2) Transglutaminase-like superfamily
PF13411 (2/2) MerR HTH family regulatory protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_77287 476.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 3

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_19328 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_groups_1879 104.64 +- 38.90 15 0 0 0 0.06 +- 0.07 15 9

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase
precursor_groups_47870 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_groups_44302 260.13 +- 5.78 2 0 0 0 0.02 +- 0.01 2 11

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00326 (2/2) riboflavin biosynthesis protein RibD
PF13641 (2/2) Glycosyltransferase like family 2
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (2/2) RibD C-terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_40334 1659.14 +- 53.80 2 0 2 0 0.01 +- 0.01 2 10

PF13622 (2/2) Thioesterase-like superfamily
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00301 (2/2) Rubredoxin
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
precursor_groups_1690 929.57 +- 1135.98 28 3 25 26 0.04 +- 0.11 25 8

PF03412 (27/28) Peptidase C39 family
PF00664 (27/28) ABC transporter transmembrane region
PF00005 (27/28) ABC transporter
TIGR03897 (26/28) type 2 lantibiotic biosynthesis protein LanM
PF13575 (26/28) Domain of unknown function (DUF4135)
PF05147 (26/28) Lanthionine synthetase C-like protein
PF14867 (23/28) Lantibiotic alpha
PF00296 (19/28) Luciferase-like monooxygenase
precursor_groups_13078 1151.39 +- 1025.31 5 1 1 4 0.05 +- 0.17 4 19

PF03176 (5/5) MMPL family
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
TIGR03605 (4/5) SagB-type dehydrogenase domain
TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/5) Methyltransferase domain
PF07993 (4/5) Male sterility protein
PF03364 (4/5) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/5) Nitroreductase family
PF00698 (4/5) Acyl transferase domain
PF00196 (4/5) Bacterial regulatory proteins, luxR family
PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/5) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/5) MOSC domain
PF01575 (3/5) MaoC like domain
PF00675 (3/5) Insulinase (Peptidase family M16)
precursor_groups_69987 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_19730 24.99 +- 2.38 2 0 0 0 0.08 +- 0.07 2 3

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00457 (2/2) Glycosyl hydrolases family 11
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_groups_7741 338.07 +- 45.25 7 0 1 0 0.09 +- 0.24 7 19

TIGR01902 (7/7) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (7/7) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (7/7) alpha-L-glutamate ligase, RimK family
PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF18130 (7/7) ATP-grasp N-terminal domain
PF13535 (7/7) ATP-grasp domain
PF08443 (7/7) RimK-like ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02779 (7/7) Transketolase, pyrimidine binding domain
PF01546 (7/7) Peptidase family M20/M25/M40
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (7/7) Amino acid kinase family
PF00456 (7/7) Transketolase, thiamine diphosphate binding domain
PF00664 (6/7) ABC transporter transmembrane region
PF00005 (6/7) ABC transporter
PF13560 (5/7) Helix-turn-helix domain
PF10901 (5/7) Protein of unknown function (DUF2690)
PF01471 (5/7) Putative peptidoglycan binding domain
precursor_groups_32566 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_563 355.50 +- 160.50 4 2 2 4 0.03 +- 0.03 2 5

PF05147 (4/4) Lanthionine synthetase C-like protein
PF01061 (4/4) ABC-2 type transporter
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein
precursor_groups_566 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase
precursor_groups_568 387.98 +- 101.27 3 0 3 0 0.06 +- 0.09 3 23

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
PF01965 (2/3) DJ-1/PfpI family
precursor_groups_569 288.11 +- 28.11 2 0 1 1 0.03 +- 0.03 2 11

TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13471 (1/2) Transglutaminase-like superfamily
PF04235 (1/2) Protein of unknown function (DUF418)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00005 (1/2) ABC transporter
precursor_groups_24085 125.56 +- 76.73 4 0 0 0 0.02 +- 0.01 4 4

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain
precursor_groups_80972 2399.40 +- 696.60 2 0 0 0 0.01 +- 0.00 2 12

PF17914 (2/2) HopA1 effector protein family
PF09335 (2/2) SNARE associated Golgi protein
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00891 (2/2) O-methyltransferase domain
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_64989 183.91 +- 13.29 2 0 0 0 0.08 +- 0.06 2 18

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_groups_4804 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix
precursor_groups_83901 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_30428 332.84 +- 267.53 3 0 0 0 0.06 +- 0.12 3 18

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
precursor_groups_27291 186.44 +- 101.19 3 0 0 0 0.02 +- 0.02 3 7

PF16353 (3/3) Domain of unknown function(DUF4981)
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_69979 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_groups_9908 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_75287 971.25 +- 3.75 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_groups_10458 320.07 +- 19.07 2 0 2 0 0.05 +- 0.02 2 18

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (2/2) Amidohydrolase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (2/2) Coenzyme A transferase
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF01965 (1/2) DJ-1/PfpI family
precursor_groups_86395 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_groups_24883 73.19 +- 11.76 2 0 2 0 0.08 +- 0.08 2 14

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13560 (2/2) Helix-turn-helix domain
PF13478 (2/2) XdhC Rossmann domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00756 (2/2) Putative esterase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_10171 369.78 +- 5.91 3 0 0 0 0.07 +- 0.20 3 16

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF15648 (3/3) Restriction endonuclease fold toxin 5
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07811 (3/3) TadE-like protein
PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter
precursor_groups_81753 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
precursor_groups_15593 303.16 +- 34.84 2 0 0 0 0.06 +- 0.10 2 19

TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (2/2) Fibronectin type III-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (2/2) Peptidase_C39 like family
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF03547 (2/2) Membrane transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_10071 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
precursor_groups_73123 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_30634 179.53 +- 21.38 2 0 2 0 0.08 +- 0.15 2 12

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450
precursor_groups_1298 137.11 +- 11.03 4 0 4 4 0.03 +- 0.04 4 3

PF13471 (4/4) Transglutaminase-like superfamily
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00733 (4/4) Asparagine synthase
precursor_groups_1110 1141.85 +- 566.92 11 6 5 11 0.02 +- 0.02 5 4

PF13471 (11/11) Transglutaminase-like superfamily
PF05402 (11/11) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (11/11) Asparagine synthase
PF00005 (9/11) ABC transporter
precursor_groups_740 69.46 +- 4.96 2 0 0 0 0.04 +- 0.04 2 8

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12802 (1/2) MarR family
precursor_groups_1501 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein
precursor_groups_44971 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
precursor_groups_1057 247.62 +- 143.54 6 0 6 6 0.02 +- 0.03 6 4

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (5/6) Lantibiotic dehydratase, N terminus
precursor_groups_35030 215.00 +- 60.81 3 0 3 0 0.01 +- 0.01 3 3

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_18349 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_groups_72835 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_45577 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_1592 252.97 +- 169.22 9 0 1 0 0.03 +- 0.07 9 5

PF07291 (9/9) Methylamine utilisation protein MauE
PF00717 (9/9) Peptidase S24-like
PF00005 (9/9) ABC transporter
PF10502 (6/9) Signal peptidase, peptidase S26
PF00578 (6/9) AhpC/TSA family
precursor_groups_42755 100.33 +- 20.27 3 0 0 0 0.02 +- 0.02 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme
precursor_groups_14774 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_77109 21.30 +- 0.66 2 0 0 0 0.09 +- 0.13 2 5

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_groups_7824 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain
precursor_groups_5193 34.39 +- 12.89 2 0 2 0 0.09 +- 0.08 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator
precursor_groups_23 417.58 +- 443.50 3 0 0 0 0.02 +- 0.05 3 3

PF03965 (2/3) Penicillinase repressor
PF01435 (2/3) Peptidase family M48
PF00403 (2/3) Heavy-metal-associated domain
precursor_groups_26 338.56 +- 113.59 5 1 3 1 0.09 +- 0.18 4 11

PF03412 (5/5) Peptidase C39 family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
TIGR03797 (4/5) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/5) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/5) HlyD family secretion protein
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/5) Major Facilitator Superfamily
PF05013 (3/5) N-formylglutamate amidohydrolase
PF03055 (3/5) Retinal pigment epithelial membrane protein
PF00440 (3/5) Bacterial regulatory proteins, tetR family
precursor_groups_3158 34.67 +- 0.00 2 0 0 0 0.09 +- 0.12 2 5

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF11361 (2/2) Protein of unknown function (DUF3159)
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (2/2) Polysaccharide deacetylase
precursor_groups_16507 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_3156 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_5697 196.34 +- 50.80 5 0 0 0 0.08 +- 0.07 5 10

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00005 (5/5) ABC transporter
PF00296 (3/5) Luciferase-like monooxygenase
precursor_groups_59389 61.28 +- 3.22 2 0 0 0 0.05 +- 0.03 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme
precursor_groups_345 885.57 +- 176.07 4 0 1 0 0.01 +- 0.01 4 9

TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (4/4) Major Facilitator Superfamily
PF03737 (4/4) Aldolase/RraA
PF03466 (4/4) LysR substrate binding domain
PF01361 (4/4) Tautomerase enzyme
PF00994 (4/4) Probable molybdopterin binding domain
PF00682 (4/4) HMGL-like
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_68668 38.91 +- 7.53 2 0 0 0 0.08 +- 0.05 2 4

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_groups_22163 437.99 +- 138.99 2 0 0 0 0.02 +- 0.10 2 18

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF12708 (1/2) Pectate lyase superfamily protein
PF12307 (1/2) Protein of unknown function (DUF3631)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF05709 (1/2) Phage tail protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_76120 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_35953 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
precursor_groups_41968 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_64500 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_16430 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_78567 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_groups_63631 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_12692 968.17 +- 676.53 5 0 5 0 0.07 +- 0.11 5 28

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (5/5) Male sterility protein
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (5/5) Copper chaperone PCu(A)C
PF03929 (5/5) PepSY-associated TM region
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (5/5) DJ-1/PfpI family
PF01794 (5/5) Ferric reductase like transmembrane component
PF01497 (5/5) Periplasmic binding protein
PF01032 (5/5) FecCD transport family
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
PF00005 (5/5) ABC transporter
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/5) Sigma-70, region 4
PF04542 (4/5) Sigma-70 region 2
precursor_groups_22188 43.48 +- 8.68 3 0 0 0 0.07 +- 0.05 3 9

PF13478 (3/3) XdhC Rossmann domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_71012 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 3

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain
precursor_groups_119 75.88 +- 0.00 2 0 0 2 0.07 +- 0.07 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase
precursor_groups_6108 87.16 +- 4.60 2 0 2 2 0.09 +- 0.18 2 12

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01292 (2/2) Prokaryotic cytochrome b561
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00188 (2/2) Cysteine-rich secretory protein family
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_groups_11480 324.25 +- 46.50 3 0 3 0 0.01 +- 0.00 3 7

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_446 1399.85 +- 1431.38 62 0 8 0 0.02 +- 0.05 62 8

PF17914 (62/62) HopA1 effector protein family
PF02441 (61/62) Flavoprotein
PF00675 (61/62) Insulinase (Peptidase family M16)
PF05193 (59/62) Peptidase M16 inactive domain
PF00296 (57/62) Luciferase-like monooxygenase
PF00005 (55/62) ABC transporter
PF00664 (35/62) ABC transporter transmembrane region
PF13649 (33/62) Methyltransferase domain
precursor_groups_14492 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II
precursor_groups_39806 205.89 +- 16.36 2 0 0 0 0.06 +- 0.11 2 15

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (2/2) Domain of unknown function (DUF4380)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_groups_22265 237.00 +- 29.70 3 0 3 0 0.01 +- 0.00 3 9

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12680 (3/3) SnoaL-like domain
PF08242 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_groups_16466 273.59 +- 115.10 6 0 0 0 0.03 +- 0.01 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_groups_16970 592.86 +- 404.30 3 0 0 0 0.05 +- 0.08 3 7

PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF01551 (3/3) Peptidase family M23
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF12679 (2/3) ABC-2 family transporter protein
precursor_groups_41831 445.71 +- 74.29 2 0 2 0 0.01 +- 0.00 2 8

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_groups_114 276.73 +- 93.81 4 0 0 0 0.06 +- 0.07 4 16

TIGR01234 (2/4) ribulokinase
PF18029 (2/4) Glyoxalase-like domain
PF14200 (2/4) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/4) L-arabinose isomerase C-terminal domain
PF07690 (2/4) Major Facilitator Superfamily
PF06964 (2/4) Alpha-L-arabinofuranosidase C-terminal domain
PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA)
PF02782 (2/4) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/4) L-arabinose isomerase
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF00596 (2/4) Class II Aldolase and Adducin N-terminal domain
PF00561 (2/4) alpha/beta hydrolase fold
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain
PF00296 (2/4) Luciferase-like monooxygenase
PF00106 (2/4) short chain dehydrogenase
precursor_groups_77189 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_47289 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_groups_64817 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase
precursor_groups_23209 51.32 +- 24.99 3 0 0 0 0.05 +- 0.06 3 7

PF13424 (3/3) Tetratricopeptide repeat
PF07719 (3/3) Tetratricopeptide repeat
PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03413 (3/3) Peptidase propeptide and YPEB domain
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00348 (3/3) Polyprenyl synthetase
precursor_groups_48894 118.75 +- 11.25 2 0 0 0 0.08 +- 0.11 2 7

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_groups_27600 144.98 +- 11.02 2 0 0 0 0.09 +- 0.06 2 16

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
precursor_groups_15312 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_groups_15314 161.25 +- 96.75 2 0 0 0 0.02 +- 0.03 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR00666 (2/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (2/2) Protein of unknown function (DUF4232)
PF10503 (2/2) Esterase PHB depolymerase
PF02113 (2/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_groups_67526 414.64 +- 27.64 2 0 0 0 0.01 +- 0.00 2 3

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase
precursor_groups_8062 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_groups_22919 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_624 260.57 +- 94.71 2 0 1 0 0.04 +- 0.05 2 10

PF12770 (2/2) CHAT domain
PF17866 (1/2) AAA lid domain
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13229 (1/2) Right handed beta helix region
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00082 (1/2) Subtilase family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_4272 23.45 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_1627 148.42 +- 88.47 10 0 0 10 0.03 +- 0.02 10 3

PF13649 (10/10) Methyltransferase domain
PF07690 (10/10) Major Facilitator Superfamily
PF04055 (10/10) Radical SAM superfamily
precursor_groups_62305 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1150 366.81 +- 92.54 7 0 7 7 0.07 +- 0.08 7 12

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF13191 (7/7) AAA ATPase domain
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF03704 (7/7) Bacterial transcriptional activator domain
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (7/7) ABC-2 type transporter
PF00881 (7/7) Nitroreductase family
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00005 (7/7) ABC transporter
precursor_groups_79452 372.32 +- 128.18 2 0 0 0 0.03 +- 0.03 2 9

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_37210 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_19241 148.40 +- 67.91 5 0 0 0 0.02 +- 0.02 5 3

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_23731 734.34 +- 335.62 4 0 4 0 0.06 +- 0.06 4 28

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10862 (4/4) FcoT-like thioesterase domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (4/4) Sigma-70, region 4
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (4/4) Sigma-70 region 2
PF04314 (4/4) Copper chaperone PCu(A)C
PF03929 (4/4) PepSY-associated TM region
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (4/4) DJ-1/PfpI family
PF01794 (4/4) Ferric reductase like transmembrane component
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00403 (4/4) Heavy-metal-associated domain
PF00122 (4/4) E1-E2 ATPase
PF00005 (4/4) ABC transporter
precursor_groups_1023 516.00 +- 129.00 2 0 2 2 0.01 +- 0.00 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (1/2) ABC transporter
precursor_groups_1534 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain
precursor_groups_1431 46.64 +- 3.06 3 0 0 0 0.06 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain
precursor_groups_17315 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_groups_21458 137.60 +- 68.80 2 0 0 0 0.06 +- 0.05 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_43861 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_groups_21455 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
precursor_groups_63 217.46 +- 123.66 7 0 0 0 0.04 +- 0.04 7

No common domains found
precursor_groups_63015 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter
precursor_groups_61 412.74 +- 203.81 6 0 0 0 0.06 +- 0.19 6 16

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF00691 (6/6) OmpA family
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF07730 (5/6) Histidine kinase
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain
TIGR03177 (4/6) Flp pilus assembly protein CpaB
PF16976 (4/6) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/6) AAA domain
PF07811 (4/6) TadE-like protein
PF00437 (4/6) Type II/IV secretion system protein
PF15648 (3/6) Restriction endonuclease fold toxin 5
PF13231 (3/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00496 (3/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/6) ABC transporter
precursor_groups_13996 34.94 +- 12.33 2 0 0 0 0.07 +- 0.06 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF01872 (2/2) RibD C-terminal domain
precursor_groups_1870 187.80 +- 17.00 2 0 2 2 0.07 +- 0.08 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
TIGR03605 (1/2) SagB-type dehydrogenase domain
PF00931 (1/2) NB-ARC domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_18839 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_9334 94.90 +- 28.28 4 0 0 0 0.04 +- 0.02 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_groups_30764 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_42885 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
precursor_groups_83319 132.91 +- 39.09 2 0 0 0 0.05 +- 0.09 2 7

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_57593 1632.40 +- 187.60 2 0 2 2 0.01 +- 0.00 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_groups_18 1139.50 +- 368.96 3 0 0 2 0.03 +- 0.12 3 5

PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF01636 (2/3) Phosphotransferase enzyme family
PF00196 (2/3) Bacterial regulatory proteins, luxR family
precursor_groups_6879 358.32 +- 74.43 10 0 6 0 0.06 +- 0.03 10 18

PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF01144 (10/10) Coenzyme A transferase
PF00378 (10/10) Enoyl-CoA hydratase/isomerase
PF00196 (10/10) Bacterial regulatory proteins, luxR family
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00106 (10/10) short chain dehydrogenase
PF00005 (10/10) ABC transporter
TIGR00976 (9/10) hydrolase CocE/NonD family protein
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF12679 (9/10) ABC-2 family transporter protein
PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/10) AMP-binding enzyme
PF04909 (8/10) Amidohydrolase
PF12697 (7/10) Alpha/beta hydrolase family
precursor_groups_4652 1090.53 +- 409.47 2 0 0 2 0.04 +- 0.03 2 31

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (2/2) Glycosyl hydrolases family 15
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13671 (1/2) AAA domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13242 (1/2) HAD-hyrolase-like
PF10103 (1/2) Zincin-like metallopeptidase
PF09364 (1/2) XFP N-terminal domain
PF09363 (1/2) XFP C-terminal domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (1/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01300 (1/2) Telomere recombination
precursor_groups_17 441.98 +- 419.76 19 0 7 4 0.03 +- 0.06 19 2

PF13370 (13/19) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (10/19) Cytochrome P450
precursor_groups_1448 73.23 +- 29.66 4 0 0 0 0.05 +- 0.06 4 5

PF14534 (4/4) Domain of unknown function (DUF4440)
PF08002 (4/4) Protein of unknown function (DUF1697)
PF05922 (4/4) Peptidase inhibitor I9
PF00082 (4/4) Subtilase family
PF01323 (2/4) DSBA-like thioredoxin domain
precursor_groups_15 314.31 +- 204.63 20 0 19 0 0.06 +- 0.15 20 15

PF03621 (20/20) MbtH-like protein
PF00501 (19/20) AMP-binding enzyme
TIGR01733 (18/20) amino acid adenylation domain
PF13193 (18/20) AMP-binding enzyme C-terminal domain
PF00668 (18/20) Condensation domain
PF00550 (18/20) Phosphopantetheine attachment site
PF00975 (16/20) Thioesterase domain
TIGR01720 (13/20) non-ribosomal peptide synthase domain TIGR01720
TIGR03945 (11/20) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (11/20) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01188 (11/20) daunorubicin resistance ABC transporter, ATP-binding protein
PF02423 (11/20) Ornithine cyclodeaminase/mu-crystallin family
PF01061 (11/20) ABC-2 type transporter
PF00291 (11/20) Pyridoxal-phosphate dependent enzyme
PF00005 (11/20) ABC transporter
precursor_groups_3028 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
precursor_groups_9053 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_7584 511.36 +- 133.14 5 0 2 0 0.04 +- 0.17 5 7

PF17914 (5/5) HopA1 effector protein family
PF02441 (5/5) Flavoprotein
PF01636 (5/5) Phosphotransferase enzyme family
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (4/5) ABC transporter
PF02897 (3/5) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/5) Prolyl oligopeptidase family
precursor_groups_22780 960.29 +- 332.05 5 0 0 0 0.02 +- 0.01 5 9

PF13649 (5/5) Methyltransferase domain
PF12698 (5/5) ABC-2 family transporter protein
PF02441 (5/5) Flavoprotein
PF00005 (5/5) ABC transporter
PF17914 (4/5) HopA1 effector protein family
PF01636 (4/5) Phosphotransferase enzyme family
PF00664 (4/5) ABC transporter transmembrane region
PF13732 (3/5) Domain of unknown function (DUF4162)
PF00196 (3/5) Bacterial regulatory proteins, luxR family
precursor_groups_82316 889.37 +- 45.01 2 0 2 0 0.06 +- 0.17 2 27

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (2/2) GYF domain 2
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13421 (2/2) SPFH domain-Band 7 family
PF08281 (2/2) Sigma-70, region 4
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03824 (2/2) High-affinity nickel-transport protein
PF01070 (2/2) FMN-dependent dehydrogenase
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00067 (2/2) Cytochrome P450
TIGR01733 (1/2) amino acid adenylation domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/2) Male sterility protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
precursor_groups_68599 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_150 243.84 +- 133.73 4 0 1 4 0.07 +- 0.08 4 8

TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01497 (2/4) Periplasmic binding protein
PF01032 (2/4) FecCD transport family
precursor_groups_68754 381.16 +- 102.59 2 0 0 0 0.02 +- 0.02 2 4

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_groups_12312 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_16088 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_groups_21277 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_groups_78723 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_2140 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family
precursor_groups_2388 699.99 +- 270.33 3 0 3 0 0.07 +- 0.19 3 27

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (3/3) GYF domain 2
PF13421 (3/3) SPFH domain-Band 7 family
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF03824 (3/3) High-affinity nickel-transport protein
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
TIGR01733 (2/3) amino acid adenylation domain
PF13738 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF10862 (2/3) FcoT-like thioesterase domain
PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/3) Male sterility protein
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01070 (2/3) FMN-dependent dehydrogenase
PF00668 (2/3) Condensation domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
PF00067 (2/3) Cytochrome P450
precursor_groups_23252 68.37 +- 29.84 3 0 0 0 0.07 +- 0.06 3 8

TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain
PF13399 (3/3) LytR cell envelope-related transcriptional attenuator
PF07859 (3/3) alpha/beta hydrolase fold
PF03816 (3/3) Cell envelope-related transcriptional attenuator domain
PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00459 (3/3) Inositol monophosphatase family
precursor_groups_36304 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_574 693.83 +- 224.35 3 0 2 3 0.05 +- 0.16 3 23

TIGR04364 (3/3) methyltransferase, FxLD system
TIGR04363 (3/3) FxLD family lantipeptide
TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13581 (2/3) Histidine kinase-like ATPase domain
PF05331 (2/3) Protein of unknown function (DUF742)
PF04851 (2/3) Type III restriction enzyme, res subunit
PF04672 (2/3) S-adenosyl methyltransferase
PF03457 (2/3) Helicase associated domain
PF03259 (2/3) Roadblock/LC7 domain
PF03029 (2/3) Conserved hypothetical ATP binding protein
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/3) Phosphotransferase enzyme family
PF01590 (2/3) GAF domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/3) NUDIX domain
PF00271 (2/3) Helicase conserved C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00005 (2/3) ABC transporter
precursor_groups_13665 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_groups_32252 379.18 +- 103.46 3 0 3 0 0.08 +- 0.09 3 29

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (3/3) DJ-1/PfpI family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
precursor_groups_274 770.06 +- 659.94 2 0 0 0 0.03 +- 0.05 2 15

PF00005 (2/2) ABC transporter
PF14903 (1/2) WG containing repeat
PF14435 (1/2) SUKH-4 immunity protein
PF10042 (1/2) Uncharacterized conserved protein (DUF2278)
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
PF05193 (1/2) Peptidase M16 inactive domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01937 (1/2) Protein of unknown function DUF89
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00950 (1/2) ABC 3 transport family
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_64854 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_48856 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
precursor_groups_279 104.13 +- 69.20 2 0 0 0 0.08 +- 0.16 2 6

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
precursor_groups_47384 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_groups_13328 1552.41 +- 1036.67 5 0 5 0 0.02 +- 0.08 5 11

PF13622 (5/5) Thioesterase-like superfamily
PF07690 (5/5) Major Facilitator Superfamily
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00487 (5/5) Fatty acid desaturase
PF00301 (5/5) Rubredoxin
PF00067 (5/5) Cytochrome P450
PF12679 (4/5) ABC-2 family transporter protein
PF12146 (4/5) Serine aminopeptidase, S33
PF00005 (4/5) ABC transporter
PF00392 (3/5) Bacterial regulatory proteins, gntR family
precursor_groups_72506 195.60 +- 94.65 2 0 2 0 0.02 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain
precursor_groups_10496 2158.41 +- 761.00 8 0 1 0 0.01 +- 0.01 8 12

PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF05193 (8/8) Peptidase M16 inactive domain
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (8/8) Insulinase (Peptidase family M16)
PF00005 (8/8) ABC transporter
PF17874 (7/8) MalT-like TPR region
precursor_groups_1211 920.66 +- 794.45 2 0 0 0 0.02 +- 0.10 2 20

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF10145 (1/2) Phage-related minor tail protein
PF05065 (1/2) Phage capsid family
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01580 (1/2) FtsK/SpoIIIE family
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01381 (1/2) Helix-turn-helix
PF01183 (1/2) Glycosyl hydrolases family 25
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_4654 359.93 +- 257.30 9 0 9 0 0.04 +- 0.07 9 10

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase
precursor_groups_7635 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_80912 1334.20 +- 95.80 2 0 0 0 0.02 +- 0.01 2 9

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF12698 (2/2) ABC-2 family transporter protein
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13732 (1/2) Domain of unknown function (DUF4162)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_84735 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
precursor_groups_888 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_5445 48.47 +- 11.07 7 0 0 0 0.07 +- 0.10 7 5

PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (7/7) [2Fe-2S] binding domain
PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
jaccard_groups_437 1352.84 +- 864.00 2 0 0 0 0.01 +- 0.01 2 26

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
PF16177 (1/2) Acetyl-coenzyme A synthetase N-terminus
PF13607 (1/2) Succinyl-CoA ligase like flavodoxin domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (1/2) Bacterial extracellular solute-binding protein
PF13380 (1/2) CoA binding domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07729 (1/2) FCD domain
PF07690 (1/2) Major Facilitator Superfamily
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02803 (1/2) Thiolase, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01575 (1/2) MaoC like domain
PF01494 (1/2) FAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
PF00108 (1/2) Thiolase, N-terminal domain
PF00005 (1/2) ABC transporter
jaccard_groups_114 714.44 +- 930.96 4 0 2 0 0.03 +- 0.07 4 2

PF02983 (4/4) Alpha-lytic protease prodomain
PF00089 (4/4) Trypsin
jaccard_groups_2124 68.58 +- 37.00 4 0 0 0 0.05 +- 0.03 4 3

PF13520 (4/4) Amino acid permease
PF00202 (4/4) Aminotransferase class-III
PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_3027 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
jaccard_groups_2120 447.92 +- 197.08 2 0 2 1 0.01 +- 0.01 2 8

PF07993 (2/2) Male sterility protein
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase
PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_6077 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
jaccard_groups_3186 43.41 +- 0.41 2 0 2 0 0.07 +- 0.09 2 5

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_1447 1179.64 +- 1207.20 3 0 3 0 0.05 +- 0.14 3 11

TIGR01830 (3/3) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12146 (3/3) Serine aminopeptidase, S33
PF07977 (3/3) FabA-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01323 (3/3) DSBA-like thioredoxin domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02786 (2/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF00698 (2/3) Acyl transferase domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_2909 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3611 153.06 +- 34.46 4 0 4 0 0.06 +- 0.13 4 25

TIGR01762 (4/4) chlorinating enzyme
TIGR01733 (4/4) amino acid adenylation domain
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01444 (4/4) methyltransferase, FkbM family
TIGR00843 (4/4) benzoate transporter
PF16990 (4/4) Carbohydrate binding module (family 35)
PF13560 (4/4) Helix-turn-helix domain
PF13535 (4/4) ATP-grasp domain
PF13454 (4/4) FAD-NAD(P)-binding
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07691 (4/4) PA14 domain
PF06439 (4/4) Domain of Unknown Function (DUF1080)
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/4) Methyltransferase FkbM domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF03594 (4/4) Benzoate membrane transport protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_4237 559.06 +- 431.39 3 0 1 3 0.02 +- 0.04 3 13

PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13280 (3/3) WYL domain
PF08279 (3/3) HTH domain
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF00730 (3/3) HhH-GPD superfamily base excision DNA repair protein
PF00293 (3/3) NUDIX domain
PF00152 (3/3) tRNA synthetases class II (D, K and N)
PF00005 (3/3) ABC transporter
PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family
jaccard_groups_177 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
jaccard_groups_171 180.52 +- 200.37 17 0 3 0 0.03 +- 0.04 17 3

PF02868 (17/17) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (17/17) Thermolysin metallopeptidase, catalytic domain
PF07504 (15/17) Fungalysin/Thermolysin Propeptide Motif
jaccard_groups_172 131.15 +- 103.02 10 0 1 0 0.03 +- 0.04 10 3

PF11716 (10/10) Mycothiol maleylpyruvate isomerase N-terminal domain
TIGR03083 (9/10) uncharacterized Actinobacterial protein TIGR03083
PF07398 (6/10) MDMPI C-terminal domain
jaccard_groups_173 330.72 +- 274.50 18 0 18 0 0.05 +- 0.15 18 11

PF16197 (18/18) Ketoacyl-synthetase C-terminal extension
PF02801 (18/18) Beta-ketoacyl synthase, C-terminal domain
PF00668 (18/18) Condensation domain
PF00550 (18/18) Phosphopantetheine attachment site
PF00109 (18/18) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (17/18) amino acid adenylation domain
PF13193 (17/18) AMP-binding enzyme C-terminal domain
PF00698 (17/18) Acyl transferase domain
PF00501 (17/18) AMP-binding enzyme
PF00975 (15/18) Thioesterase domain
PF07690 (10/18) Major Facilitator Superfamily
jaccard_groups_6305 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
jaccard_groups_2973 375.44 +- 131.77 2 0 2 0 0.09 +- 0.21 2 34

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF00857 (1/2) Isochorismatase family
jaccard_groups_2691 259.00 +- 1.00 2 0 1 0 0.01 +- 0.00 2 4

PF13243 (2/2) Squalene-hopene cyclase C-terminal domain
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00348 (1/2) Polyprenyl synthetase
PF00293 (1/2) NUDIX domain
jaccard_groups_489 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_642 315.42 +- 243.98 35 0 2 0 0.03 +- 0.04 35 8

TIGR03920 (35/35) type VII secretion integral membrane protein EccD
TIGR03919 (35/35) type VII secretion protein EccB
PF08817 (35/35) WXG100 protein secretion system (Wss), protein YukD
PF05108 (35/35) Type VII secretion system ESX-1, transport TM domain B
PF02575 (34/35) YbaB/EbfC DNA-binding family
PF06013 (29/35) Proteins of 100 residues with WXG
TIGR03930 (26/35) WXG100 family type VII secretion target
PF07179 (20/35) SseB protein N-terminal domain
jaccard_groups_2674 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
jaccard_groups_2676 260.26 +- 108.12 9 0 9 9 0.05 +- 0.03 9 13

TIGR04451 (9/9) lantipeptide, SCO0268 family
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF12802 (9/9) MarR family
PF12697 (9/9) Alpha/beta hydrolase family
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF02065 (9/9) Melibiase
PF01547 (9/9) Bacterial extracellular solute-binding protein
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00480 (9/9) ROK family
PF02894 (8/9) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/9) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_5583 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
jaccard_groups_4356 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_2472 1010.92 +- 468.30 4 0 0 4 0.03 +- 0.04 4 25

TIGR03812 (4/4) tyrosine decarboxylase MnfA
PF17755 (4/4) UvrA DNA-binding domain
PF16861 (4/4) Carbamoyltransferase C-terminus
PF16169 (4/4) Domain of unknown function (DUF4872)
PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (4/4) DNA alkylation repair enzyme
PF08241 (4/4) Methyltransferase domain
PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (4/4) Radical SAM superfamily
PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (4/4) Carbamoyltransferase N-terminus
PF02310 (4/4) B12 binding domain
PF02195 (4/4) ParB-like nuclease domain
PF01613 (4/4) Flavin reductase like domain
PF01568 (4/4) Molydopterin dinucleotide binding domain
PF01061 (4/4) ABC-2 type transporter
PF00805 (4/4) Pentapeptide repeats (8 copies)
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00384 (4/4) Molybdopterin oxidoreductase
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (4/4) ABC transporter
PF00501 (3/4) AMP-binding enzyme
jaccard_groups_5613 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_289 586.17 +- 706.86 6 0 0 0 0.02 +- 0.03 6 6

TIGR03930 (6/6) WXG100 family type VII secretion target
PF06013 (6/6) Proteins of 100 residues with WXG
TIGR03921 (5/6) type VII secretion-associated serine protease mycosin
PF05108 (5/6) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/6) Subtilase family
TIGR03919 (4/6) type VII secretion protein EccB
jaccard_groups_5572 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
jaccard_groups_795 339.13 +- 0.00 2 0 0 0 0.03 +- 0.01 2 8

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
jaccard_groups_4775 763.96 +- 609.16 2 0 2 1 0.05 +- 0.14 2 24

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
jaccard_groups_5270 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
jaccard_groups_1652 427.40 +- 123.00 2 0 2 0 0.03 +- 0.03 2 6

TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
jaccard_groups_3940 1767.52 +- 216.09 3 0 1 3 0.01 +- 0.02 3 10

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family
jaccard_groups_594 215.75 +- 52.67 4 0 0 0 0.02 +- 0.04 4 3

TIGR03086 (4/4) TIGR03086 family protein
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF01814 (2/4) Hemerythrin HHE cation binding domain
jaccard_groups_4857 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family
jaccard_groups_5054 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
jaccard_groups_5724 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_50 561.62 +- 388.29 2 0 0 0 0.01 +- 0.01 2 12

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (1/2) GAF domain
PF12770 (1/2) CHAT domain
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF07690 (1/2) Major Facilitator Superfamily
PF01872 (1/2) RibD C-terminal domain
PF01047 (1/2) MarR family
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_52 45.69 +- 30.15 4 0 1 0 0.07 +- 0.09 4 5

TIGR01525 (4/4) heavy metal translocating P-type ATPase
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00122 (4/4) E1-E2 ATPase
PF04314 (3/4) Copper chaperone PCu(A)C
PF00403 (3/4) Heavy-metal-associated domain
jaccard_groups_55 162.82 +- 79.43 8 0 0 0 0.03 +- 0.03 8 2

PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF00107 (8/8) Zinc-binding dehydrogenase
jaccard_groups_946 223.40 +- 135.81 3 0 2 0 0.03 +- 0.04 3 7

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF18130 (2/3) ATP-grasp N-terminal domain
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00155 (2/3) Aminotransferase class I and II
jaccard_groups_866 47.52 +- 9.22 3 0 0 0 0.04 +- 0.05 3 3

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_948 1680.69 +- 1143.93 5 0 3 5 0.04 +- 0.12 5 8

PF13649 (5/5) Methyltransferase domain
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00202 (5/5) Aminotransferase class-III
PF00005 (5/5) ABC transporter
PF12730 (4/5) ABC-2 family transporter protein
PF00296 (4/5) Luciferase-like monooxygenase
PF00069 (4/5) Protein kinase domain
PF05147 (3/5) Lanthionine synthetase C-like protein
jaccard_groups_864 1319.20 +- 1319.09 76 0 14 0 0.02 +- 0.04 76 9

PF17914 (75/76) HopA1 effector protein family
PF02441 (74/76) Flavoprotein
PF00675 (71/76) Insulinase (Peptidase family M16)
PF00005 (68/76) ABC transporter
PF05193 (67/76) Peptidase M16 inactive domain
PF00296 (61/76) Luciferase-like monooxygenase
PF13649 (43/76) Methyltransferase domain
PF00664 (42/76) ABC transporter transmembrane region
PF01636 (40/76) Phosphotransferase enzyme family
jaccard_groups_3200 400.13 +- 221.16 3 0 1 0 0.05 +- 0.17 3 26

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain
jaccard_groups_219 238.29 +- 148.71 2 0 2 0 0.03 +- 0.04 2 6

PF17900 (2/2) Peptidase M1 N-terminal domain
PF01433 (2/2) Peptidase family M1 domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00293 (1/2) NUDIX domain
PF00067 (1/2) Cytochrome P450
jaccard_groups_216 135.76 +- 125.47 4 0 0 0 0.04 +- 0.03 4 6

PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF07690 (3/4) Major Facilitator Superfamily
PF05721 (2/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00378 (2/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_212 129.71 +- 150.27 3 0 0 0 0.07 +- 0.07 3 3

PF00753 (3/3) Metallo-beta-lactamase superfamily
PF13370 (2/3) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/3) Methyltransferase domain
jaccard_groups_3386 273.84 +- 106.57 7 0 1 0 0.03 +- 0.01 7 7

PF07690 (7/7) Major Facilitator Superfamily
PF05378 (7/7) Hydantoinase/oxoprolinase N-terminal region
PF02538 (7/7) Hydantoinase B/oxoprolinase
PF01968 (7/7) Hydantoinase/oxoprolinase
PF01380 (7/7) SIS domain
PF01019 (7/7) Gamma-glutamyltranspeptidase
PF00294 (7/7) pfkB family carbohydrate kinase
jaccard_groups_3382 111.05 +- 61.85 5 0 0 0 0.05 +- 0.05 5 8

TIGR00350 (5/5) cell envelope-related function transcriptional attenuator common domain
PF13399 (5/5) LytR cell envelope-related transcriptional attenuator
PF07859 (5/5) alpha/beta hydrolase fold
PF03816 (5/5) Cell envelope-related transcriptional attenuator domain
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF01258 (5/5) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase
PF00459 (5/5) Inositol monophosphatase family
jaccard_groups_6289 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
jaccard_groups_3720 427.75 +- 162.91 4 0 0 0 0.02 +- 0.01 4 8

PF11723 (4/4) Homotrimeric ring hydroxylase
PF02900 (4/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (4/4) Peptidase family M20/M25/M40
PF00561 (4/4) alpha/beta hydrolase fold
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF12697 (3/4) Alpha/beta hydrolase family
PF00175 (3/4) Oxidoreductase NAD-binding domain
jaccard_groups_6235 2080.00 +- 260.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02597 (2/2) ThiS family
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF02310 (2/2) B12 binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_3370 332.84 +- 267.53 3 0 0 0 0.06 +- 0.12 3 18

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
jaccard_groups_3371 68.23 +- 18.44 2 0 1 0 0.05 +- 0.04 2 6

TIGR00345 (2/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF02554 (2/2) Carbon starvation protein CstA
PF02374 (2/2) Anion-transporting ATPase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4
jaccard_groups_500 34.39 +- 12.89 2 0 2 0 0.09 +- 0.08 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator
jaccard_groups_509 390.00 +- 0.00 3 0 2 0 0.01 +- 0.00 3 4

PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (3/3) Flavin reductase like domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
jaccard_groups_1276 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
jaccard_groups_767 151.70 +- 47.50 3 0 0 0 0.07 +- 0.10 3 7

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
PF09995 (2/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF05719 (2/3) Golgi phosphoprotein 3 (GPP34)
jaccard_groups_761 729.04 +- 362.80 9 0 5 9 0.05 +- 0.11 9 19

TIGR04364 (9/9) methyltransferase, FxLD system
TIGR04363 (9/9) FxLD family lantipeptide
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF05331 (9/9) Protein of unknown function (DUF742)
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF03259 (9/9) Roadblock/LC7 domain
PF03029 (9/9) Conserved hypothetical ATP binding protein
PF01135 (9/9) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (9/9) NUDIX domain
PF00196 (9/9) Bacterial regulatory proteins, luxR family
PF00005 (9/9) ABC transporter
PF02771 (7/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (7/9) Acyl-CoA dehydrogenase, middle domain
PF01590 (7/9) GAF domain
PF01427 (7/9) D-ala-D-ala dipeptidase
PF00441 (7/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00723 (5/9) Glycosyl hydrolases family 15
jaccard_groups_763 1162.04 +- 959.64 85 28 57 84 0.03 +- 0.08 57 7

PF00005 (85/85) ABC transporter
PF13575 (84/85) Domain of unknown function (DUF4135)
PF05147 (84/85) Lanthionine synthetase C-like protein
PF00664 (84/85) ABC transporter transmembrane region
PF03412 (83/85) Peptidase C39 family
TIGR03897 (79/85) type 2 lantibiotic biosynthesis protein LanM
PF14867 (43/85) Lantibiotic alpha
jaccard_groups_139 331.74 +- 178.03 5 0 3 0 0.02 +- 0.02 5 8

PF02780 (5/5) Transketolase, C-terminal domain
PF00676 (5/5) Dehydrogenase E1 component
PF00364 (5/5) Biotin-requiring enzyme
PF00198 (5/5) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF02779 (4/5) Transketolase, pyrimidine binding domain
PF08545 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/5) Phosphopantetheine attachment site
jaccard_groups_1879 1882.17 +- 1757.83 2 0 0 0 0.05 +- 0.07 2 17

PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13802 (1/2) Galactose mutarotase-like
PF08244 (1/2) Glycosyl hydrolases family 32 C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01833 (1/2) IPT/TIG domain
PF01055 (1/2) Glycosyl hydrolases family 31
PF00754 (1/2) F5/8 type C domain
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_6462 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
jaccard_groups_3129 864.29 +- 155.78 3 0 3 3 0.01 +- 0.02 3 9

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_3796 214.87 +- 119.93 4 0 0 0 0.02 +- 0.03 4 4

PF05901 (4/4) Excalibur calcium-binding domain
PF01738 (4/4) Dienelactone hydrolase family
PF00293 (4/4) NUDIX domain
PF00067 (2/4) Cytochrome P450
jaccard_groups_6512 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2010 142.50 +- 52.50 2 0 0 0 0.05 +- 0.07 2 18

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00392 (2/2) Bacterial regulatory proteins, gntR family
TIGR00791 (1/2) transporter, gluconate:H+ symporter (GntP) family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13407 (1/2) Periplasmic binding protein domain
PF13185 (1/2) GAF domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01614 (1/2) Bacterial transcriptional regulator
PF00775 (1/2) Dioxygenase
jaccard_groups_3159 284.37 +- 95.70 5 0 1 0 0.03 +- 0.05 5 8

PF12833 (5/5) Helix-turn-helix domain
PF02774 (5/5) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (5/5) DJ-1/PfpI family
PF01118 (5/5) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (5/5) Amino acid kinase family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00171 (5/5) Aldehyde dehydrogenase family
PF00465 (4/5) Iron-containing alcohol dehydrogenase
jaccard_groups_2206 139.29 +- 9.29 2 0 0 0 0.03 +- 0.02 2 7

PF13460 (2/2) NAD(P)H-binding
PF00561 (2/2) alpha/beta hydrolase fold
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01494 (1/2) FAD binding domain
jaccard_groups_1473 113.82 +- 0.00 2 0 0 0 0.08 +- 0.05 2 6

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF04203 (1/2) Sortase domain
jaccard_groups_1478 1029.59 +- 549.79 5 2 3 5 0.03 +- 0.03 3 10

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (5/5) ABC-2 type transporter
PF00733 (5/5) Asparagine synthase
PF00005 (5/5) ABC transporter
TIGR01188 (3/5) daunorubicin resistance ABC transporter, ATP-binding protein
PF13462 (3/5) Thioredoxin
PF07730 (3/5) Histidine kinase
PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00072 (3/5) Response regulator receiver domain
jaccard_groups_997 144.69 +- 113.31 2 0 0 0 0.04 +- 0.06 2 5

PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF13560 (2/2) Helix-turn-helix domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF04149 (2/2) Domain of unknown function (DUF397)
jaccard_groups_994 250.84 +- 78.71 6 0 0 0 0.03 +- 0.11 6 16

TIGR01558 (6/6) putative phage terminase, small subunit, P27 family
TIGR01554 (6/6) phage major capsid protein, HK97 family
TIGR01543 (6/6) phage prohead protease, HK97 family
TIGR01537 (6/6) phage portal protein, HK97 family
PF10145 (6/6) Phage-related minor tail protein
PF05119 (6/6) Phage terminase, small subunit
PF05065 (6/6) Phage capsid family
PF04860 (6/6) Phage portal protein
PF04586 (6/6) Caudovirus prohead serine protease
PF03354 (6/6) Phage Terminase
PF01510 (6/6) N-acetylmuramoyl-L-alanine amidase
PF01381 (6/6) Helix-turn-helix
PF16945 (4/6) Putative lactococcus lactis phage r1t holin
PF13229 (4/6) Right handed beta helix region
PF01476 (4/6) LysM domain
PF01464 (4/6) Transglycosylase SLT domain
jaccard_groups_5913 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
jaccard_groups_993 66.40 +- 35.34 2 0 1 0 0.06 +- 0.08 2 13

PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF16259 (1/2) Domain of unknown function (DUF4913)
PF13649 (1/2) Methyltransferase domain
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12307 (1/2) Protein of unknown function (DUF3631)
PF08239 (1/2) Bacterial SH3 domain
PF01555 (1/2) DNA methylase
jaccard_groups_4482 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
jaccard_groups_4093 886.61 +- 688.91 3 0 0 0 0.03 +- 0.01 3 18

TIGR03561 (3/3) peroxiredoxin, Ohr subfamily
PF13649 (3/3) Methyltransferase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF02566 (3/3) OsmC-like protein
PF01614 (3/3) Bacterial transcriptional regulator
PF01546 (3/3) Peptidase family M20/M25/M40
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF04199 (2/3) Putative cyclase
PF03972 (2/3) MmgE/PrpD family
PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/3) CoA-transferase family III
PF01979 (2/3) Amidohydrolase family
jaccard_groups_4722 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_5898 600.85 +- 188.32 2 0 0 0 0.03 +- 0.04 2 20

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (2/2) Rrf2 family protein
PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (2/2) Thioredoxin
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (2/2) Transcriptional regulator
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (2/2) Molybdopterin oxidoreductase
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08386 (1/2) TAP-like protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01909 (1/2) Nucleotidyltransferase domain
jaccard_groups_1054 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
jaccard_groups_1976 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter
jaccard_groups_2336 40.24 +- 11.75 3 0 0 0 0.08 +- 0.17 3 3

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C
jaccard_groups_1114 241.84 +- 175.07 6 0 0 0 0.05 +- 0.05 6 10

PF16353 (6/6) Domain of unknown function(DUF4981)
PF02929 (6/6) Beta galactosidase small chain
PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/6) Glycosyl hydrolases family 2
PF13385 (3/6) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/6) Uncharacterized protein conserved in bacteria (DUF2236)
PF01547 (3/6) Bacterial extracellular solute-binding protein
PF01074 (3/6) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
jaccard_groups_2849 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
jaccard_groups_4006 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1505 104.64 +- 38.90 15 0 0 0 0.06 +- 0.07 15 9

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase
jaccard_groups_618 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_610 172.00 +- 34.40 2 0 0 0 0.02 +- 0.03 2 5

PF00891 (2/2) O-methyltransferase domain
PF16864 (1/2) Dimerisation domain
PF13649 (1/2) Methyltransferase domain
PF05090 (1/2) Vitamin K-dependent gamma-carboxylase
PF01212 (1/2) Beta-eliminating lyase
jaccard_groups_616 226.60 +- 172.94 7 3 3 0 0.03 +- 0.04 4 5

PF13649 (7/7) Methyltransferase domain
PF00005 (7/7) ABC transporter
PF12697 (5/7) Alpha/beta hydrolase family
PF13450 (4/7) NAD(P)-binding Rossmann-like domain
PF00664 (4/7) ABC transporter transmembrane region
jaccard_groups_2522 637.59 +- 4.54 2 0 0 0 0.03 +- 0.02 2 14

TIGR00928 (2/2) adenylosuccinate lyase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13460 (2/2) NAD(P)H-binding
PF12800 (2/2) 4Fe-4S binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00072 (2/2) Response regulator receiver domain
jaccard_groups_5316 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
jaccard_groups_4266 179.53 +- 21.38 2 0 2 0 0.08 +- 0.15 2 12

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450
jaccard_groups_61 94.60 +- 8.60 2 0 1 0 0.02 +- 0.02 2 4

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF18029 (1/2) Glyoxalase-like domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00156 (1/2) Phosphoribosyl transferase domain
jaccard_groups_5094 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_18 38.61 +- 19.66 3 0 0 0 0.07 +- 0.07 3 4

PF00271 (3/3) Helicase conserved C-terminal domain
PF00270 (3/3) DEAD/DEAH box helicase
PF10923 (2/3) P-loop Domain of unknown function (DUF2791)
PF09848 (2/3) Uncharacterized conserved protein (DUF2075)
jaccard_groups_19 138.16 +- 77.48 8 1 3 0 0.05 +- 0.10 7 5

PF07228 (7/8) Stage II sporulation protein E (SpoIIE)
PF08448 (6/8) PAS fold
TIGR00229 (5/8) PAS domain S-box protein
PF13581 (5/8) Histidine kinase-like ATPase domain
PF13185 (4/8) GAF domain
jaccard_groups_14 412.84 +- 268.06 10 0 2 1 0.03 +- 0.04 10 6

PF13377 (10/10) Periplasmic binding protein-like domain
PF00356 (10/10) Bacterial regulatory proteins, lacI family
PF00528 (7/10) Binding-protein-dependent transport system inner membrane component
PF02065 (6/10) Melibiase
PF00266 (6/10) Aminotransferase class-V
PF13416 (5/10) Bacterial extracellular solute-binding protein
jaccard_groups_1609 164.29 +- 96.60 9 0 0 0 0.05 +- 0.04 9 11

TIGR03217 (9/9) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (9/9) acetaldehyde dehydrogenase (acetylating)
PF13621 (9/9) Cupin-like domain
PF09290 (9/9) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (9/9) DmpG-like communication domain
PF07690 (9/9) Major Facilitator Superfamily
PF03328 (9/9) HpcH/HpaI aldolase/citrate lyase family
PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (9/9) HMGL-like
PF00155 (9/9) Aminotransferase class I and II
jaccard_groups_16 107.91 +- 40.97 3 0 0 0 0.05 +- 0.04 3 2

PF03466 (3/3) LysR substrate binding domain
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1975 343.46 +- 204.82 9 0 7 8 0.02 +- 0.04 9 6

PF13191 (9/9) AAA ATPase domain
PF00211 (9/9) Adenylate and Guanylate cyclase catalytic domain
PF00082 (9/9) Subtilase family
PF13185 (8/9) GAF domain
PF04055 (8/9) Radical SAM superfamily
PF14518 (5/9) Iron-containing redox enzyme
jaccard_groups_10 281.67 +- 272.44 6 0 2 1 0.04 +- 0.08 6 5

PF03704 (5/6) Bacterial transcriptional activator domain
PF00486 (5/6) Transcriptional regulatory protein, C terminal
PF00931 (4/6) NB-ARC domain
PF13424 (3/6) Tetratricopeptide repeat
PF00082 (3/6) Subtilase family
jaccard_groups_11 230.60 +- 200.58 12 0 3 2 0.05 +- 0.09 12 5

PF02518 (12/12) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/12) His Kinase A (phospho-acceptor) domain
PF00486 (12/12) Transcriptional regulatory protein, C terminal
PF00072 (12/12) Response regulator receiver domain
PF00672 (11/12) HAMP domain
jaccard_groups_3908 1645.66 +- 1357.34 2 0 2 1 0.05 +- 0.19 2 38

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
TIGR00761 (2/2) acetylglutamate kinase
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF05977 (2/2) Transmembrane secretion effector
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02039 (1/2) sulfate adenylyltransferase, small subunit
TIGR02034 (1/2) sulfate adenylyltransferase, large subunit
TIGR00455 (1/2) adenylyl-sulfate kinase
PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01583 (1/2) Adenylylsulphate kinase
PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00009 (1/2) Elongation factor Tu GTP binding domain
jaccard_groups_1501 120.00 +- 0.00 2 0 0 0 0.10 +- 0.25 2 12

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold
jaccard_groups_5008 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
jaccard_groups_5003 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_4865 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
jaccard_groups_1232 71.67 +- 26.71 5 0 0 0 0.06 +- 0.07 5 4

PF14534 (5/5) Domain of unknown function (DUF4440)
PF08002 (5/5) Protein of unknown function (DUF1697)
PF05922 (5/5) Peptidase inhibitor I9
PF00082 (5/5) Subtilase family
jaccard_groups_3541 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family
jaccard_groups_3340 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
jaccard_groups_6243 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain
jaccard_groups_4892 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
jaccard_groups_800 90.32 +- 12.32 2 0 1 0 0.03 +- 0.02 2 5

PF14759 (2/2) Reductase C-terminal
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF14518 (1/2) Iron-containing redox enzyme
PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_4890 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
jaccard_groups_4895 151.88 +- 91.88 2 0 0 0 0.04 +- 0.05 2 11

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF13333 (1/2) Integrase core domain
PF13276 (1/2) HTH-like domain
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain
jaccard_groups_677 115.84 +- 70.48 5 0 3 5 0.03 +- 0.05 5 3

PF13537 (5/5) Glutamine amidotransferase domain
PF00733 (5/5) Asparagine synthase
PF00171 (3/5) Aldehyde dehydrogenase family
jaccard_groups_546 169.85 +- 94.28 4 0 3 0 0.04 +- 0.04 4 3

PF03033 (4/4) Glycosyltransferase family 28 N-terminal domain
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00756 (3/4) Putative esterase
jaccard_groups_269 271.71 +- 249.02 8 0 1 0 0.04 +- 0.07 8 3

PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
TIGR00976 (6/8) hydrolase CocE/NonD family protein
jaccard_groups_402 569.24 +- 406.57 4 0 2 0 0.05 +- 0.06 4 5

PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF08533 (3/4) Beta-galactosidase C-terminal domain
PF01547 (3/4) Bacterial extracellular solute-binding protein
jaccard_groups_6019 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_2069 77.88 +- 16.58 6 0 0 0 0.08 +- 0.04 6 9

TIGR02133 (6/6) ribose 5-phosphate isomerase
PF16896 (6/6) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (6/6) Major Facilitator Superfamily
PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent
PF02734 (6/6) DAK2 domain
PF02733 (6/6) Dak1 domain
PF02502 (6/6) Ribose/Galactose Isomerase
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00121 (6/6) Triosephosphate isomerase
jaccard_groups_2068 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
jaccard_groups_2064 359.93 +- 257.30 9 0 9 0 0.04 +- 0.07 9 10

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase
jaccard_groups_3164 378.11 +- 182.20 6 0 6 0 0.02 +- 0.03 6 10

PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00348 (6/6) Polyprenyl synthetase
PF00106 (6/6) short chain dehydrogenase
PF00743 (5/6) Flavin-binding monooxygenase-like
TIGR01534 (4/6) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
jaccard_groups_3690 215.27 +- 98.42 5 0 5 4 0.04 +- 0.05 5 11

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
PF10025 (5/5) Uncharacterized conserved protein (DUF2267)
PF08281 (5/5) Sigma-70, region 4
PF04542 (5/5) Sigma-70 region 2
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00067 (5/5) Cytochrome P450
TIGR03975 (4/5) ribosomal peptide maturation radical SAM protein 1
PF07690 (4/5) Major Facilitator Superfamily
PF04055 (4/5) Radical SAM superfamily
PF02310 (4/5) B12 binding domain
PF00326 (4/5) Prolyl oligopeptidase family
jaccard_groups_3647 447.82 +- 139.46 3 0 1 0 0.06 +- 0.21 3 11

PF17914 (3/3) HopA1 effector protein family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02441 (3/3) Flavoprotein
PF01636 (3/3) Phosphotransferase enzyme family
PF00326 (3/3) Prolyl oligopeptidase family
PF00296 (3/3) Luciferase-like monooxygenase
PF07730 (2/3) Histidine kinase
PF01061 (2/3) ABC-2 type transporter
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
PF00005 (2/3) ABC transporter
jaccard_groups_104 29.41 +- 3.34 3 0 0 0 0.08 +- 0.06 3 3

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00106 (2/3) short chain dehydrogenase
jaccard_groups_3587 187.56 +- 79.93 4 0 0 0 0.03 +- 0.04 4 5

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
jaccard_groups_6495 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
jaccard_groups_3568 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase
jaccard_groups_163 146.25 +- 113.75 2 0 0 0 0.03 +- 0.05 2 4

PF05685 (2/2) Putative restriction endonuclease
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04149 (1/2) Domain of unknown function (DUF397)
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_2368 94.90 +- 28.28 4 0 0 0 0.04 +- 0.02 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_160 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family
jaccard_groups_1491 1089.57 +- 871.67 7 0 7 0 0.01 +- 0.00 7 6

PF03412 (7/7) Peptidase C39 family
PF00668 (7/7) Condensation domain
PF00664 (7/7) ABC transporter transmembrane region
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00005 (7/7) ABC transporter
jaccard_groups_165 144.63 +- 101.54 4 0 2 1 0.04 +- 0.04 4 7

TIGR03026 (4/4) nucleotide sugar dehydrogenase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_3769 240.97 +- 100.44 3 0 3 0 0.02 +- 0.02 3 6

PF12697 (3/3) Alpha/beta hydrolase family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00069 (3/3) Protein kinase domain
jaccard_groups_2360 197.13 +- 83.31 2 0 0 0 0.02 +- 0.02 2 11

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
TIGR03446 (1/2) mycothiol conjugate amidase Mca
PF07859 (1/2) alpha/beta hydrolase fold
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01494 (1/2) FAD binding domain
jaccard_groups_1785 273.52 +- 225.37 4 0 0 0 0.03 +- 0.07 4 3

PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (4/4) SPFH domain / Band 7 family
PF00877 (4/4) NlpC/P60 family
jaccard_groups_2807 154.14 +- 79.86 2 0 0 0 0.02 +- 0.03 2 9

PF13602 (2/2) Zinc-binding dehydrogenase
PF13564 (2/2) DoxX-like family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
jaccard_groups_2804 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain
jaccard_groups_1424 383.25 +- 193.13 12 0 2 0 0.02 +- 0.06 12 5

PF07291 (12/12) Methylamine utilisation protein MauE
PF00717 (12/12) Peptidase S24-like
PF00005 (12/12) ABC transporter
PF00578 (9/12) AhpC/TSA family
PF10502 (6/12) Signal peptidase, peptidase S26
jaccard_groups_1397 799.92 +- 505.57 9 0 9 9 0.02 +- 0.07 9 11

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
TIGR03604 (9/9) thiazole/oxazole-forming peptide maturase, SagD family component
PF03412 (9/9) Peptidase C39 family
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (9/9) Nitroreductase family
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
PF13575 (8/9) Domain of unknown function (DUF4135)
PF00067 (8/9) Cytochrome P450
PF00364 (6/9) Biotin-requiring enzyme
jaccard_groups_5864 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_1544 41.61 +- 0.00 2 0 2 0 0.10 +- 0.09 2 4

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (2/2) Major Facilitator Superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
jaccard_groups_719 282.54 +- 181.38 8 0 0 0 0.03 +- 0.05 8 6

PF07739 (8/8) TipAS antibiotic-recognition domain
PF07228 (8/8) Stage II sporulation protein E (SpoIIE)
PF13411 (7/8) MerR HTH family regulatory protein
PF07690 (6/8) Major Facilitator Superfamily
PF01551 (6/8) Peptidase family M23
PF00291 (6/8) Pyridoxal-phosphate dependent enzyme
jaccard_groups_8 552.00 +- 588.46 44 13 29 31 0.03 +- 0.05 31 6

PF00005 (44/44) ABC transporter
PF00664 (41/44) ABC transporter transmembrane region
PF00069 (38/44) Protein kinase domain
PF05147 (30/44) Lanthionine synthetase C-like protein
PF00326 (25/44) Prolyl oligopeptidase family
PF04672 (23/44) S-adenosyl methyltransferase
jaccard_groups_9 133.85 +- 102.99 5 0 2 2 0.03 +- 0.04 5 1

PF00069 (5/5) Protein kinase domain
jaccard_groups_4 163.62 +- 122.15 7 1 1 0 0.04 +- 0.05 6 1

PF07690 (7/7) Major Facilitator Superfamily
jaccard_groups_5 171.61 +- 154.50 3 0 1 0 0.07 +- 0.12 3 3

PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
jaccard_groups_2 376.95 +- 80.35 5 0 0 1 0.01 +- 0.00 5 1

PF00440 (5/5) Bacterial regulatory proteins, tetR family
jaccard_groups_3 243.73 +- 166.49 19 0 1 0 0.03 +- 0.08 19 3

PF07730 (19/19) Histidine kinase
PF00196 (19/19) Bacterial regulatory proteins, luxR family
PF00072 (19/19) Response regulator receiver domain
jaccard_groups_3864 150.05 +- 8.21 2 0 0 0 0.09 +- 0.23 2 24

TIGR03144 (2/2) cytochrome c-type biogenesis protein CcsB
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF07690 (2/2) Major Facilitator Superfamily
PF05140 (2/2) ResB-like family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF01758 (2/2) Sodium Bile acid symporter family
PF01578 (2/2) Cytochrome C assembly protein
PF01545 (2/2) Cation efflux family
PF01252 (2/2) Signal peptidase (SPase) II
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
TIGR01573 (1/2) CRISPR-associated endonuclease Cas2
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF13411 (1/2) MerR HTH family regulatory protein
PF12833 (1/2) Helix-turn-helix domain
PF10825 (1/2) Protein of unknown function (DUF2752)
PF09827 (1/2) CRISPR associated protein Cas2
PF02630 (1/2) SCO1/SenC
PF00795 (1/2) Carbon-nitrogen hydrolase
jaccard_groups_2565 345.37 +- 304.63 2 0 0 0 0.02 +- 0.03 2 6

PF00082 (2/2) Subtilase family
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13191 (1/2) AAA ATPase domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03704 (1/2) Bacterial transcriptional activator domain
jaccard_groups_293 149.38 +- 100.19 8 0 0 0 0.02 +- 0.02 8 4

PF14759 (7/8) Reductase C-terminal
PF13370 (7/8) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (7/8) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (5/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_5605 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
jaccard_groups_69 42.23 +- 13.81 3 0 1 0 0.06 +- 0.04 3 2

PF00248 (3/3) Aldo/keto reductase family
PF08007 (2/3) Cupin superfamily protein
jaccard_groups_1160 605.32 +- 462.85 23 0 23 0 0.07 +- 0.11 23 23

TIGR01733 (23/23) amino acid adenylation domain
PF13193 (23/23) AMP-binding enzyme C-terminal domain
PF10862 (23/23) FcoT-like thioesterase domain
PF08545 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (23/23) Male sterility protein
PF07690 (23/23) Major Facilitator Superfamily
PF05118 (23/23) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (23/23) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (23/23) Condensation domain
PF00550 (23/23) Phosphopantetheine attachment site
PF00501 (23/23) AMP-binding enzyme
TIGR01746 (22/23) thioester reductase domain
TIGR01525 (22/23) heavy metal translocating P-type ATPase
TIGR00747 (22/23) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF04314 (22/23) Copper chaperone PCu(A)C
PF00702 (22/23) haloacid dehalogenase-like hydrolase
PF00403 (22/23) Heavy-metal-associated domain
PF00122 (22/23) E1-E2 ATPase
PF01497 (21/23) Periplasmic binding protein
PF01032 (21/23) FecCD transport family
PF00005 (21/23) ABC transporter
PF01965 (19/23) DJ-1/PfpI family
jaccard_groups_22 134.76 +- 86.38 2 0 0 0 0.04 +- 0.07 2 3

PF12802 (2/2) MarR family
PF01965 (2/2) DJ-1/PfpI family
PF00069 (2/2) Protein kinase domain
jaccard_groups_4291 227.25 +- 162.75 2 0 0 0 0.03 +- 0.05 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
jaccard_groups_199 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
jaccard_groups_222 1424.71 +- 886.93 4 0 0 0 0.02 +- 0.05 4 9

PF07811 (4/4) TadE-like protein
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF13400 (3/4) Putative Flp pilus-assembly TadE/G-like
PF08666 (3/4) SAF domain
PF01476 (3/4) LysM domain
PF14081 (2/4) Domain of unknown function (DUF4262)
PF03704 (2/4) Bacterial transcriptional activator domain
PF01381 (2/4) Helix-turn-helix
jaccard_groups_2414 122.10 +- 43.38 4 0 0 0 0.05 +- 0.04 4 12

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
jaccard_groups_5043 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
jaccard_groups_60 278.98 +- 192.79 15 1 0 1 0.02 +- 0.04 14 1

PF00082 (15/15) Subtilase family
jaccard_groups_5049 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_25 108.15 +- 115.79 8 0 0 0 0.06 +- 0.06 8 5

PF05331 (8/8) Protein of unknown function (DUF742)
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF00067 (8/8) Cytochrome P450
PF04149 (6/8) Domain of unknown function (DUF397)
jaccard_groups_26 115.49 +- 100.95 3 0 0 0 0.04 +- 0.04 3 1

PF00293 (3/3) NUDIX domain
jaccard_groups_21 325.60 +- 323.07 3 0 0 0 0.03 +- 0.08 3 6

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01443 (2/3) intein C-terminal splicing region
PF13385 (2/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat
jaccard_groups_23 135.79 +- 170.09 4 0 0 0 0.07 +- 0.12 4 4

PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (3/4) Major Facilitator Superfamily
jaccard_groups_4226 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
jaccard_groups_3896 821.14 +- 717.35 4 0 0 0 0.05 +- 0.15 4 21

TIGR01928 (4/4) o-succinylbenzoate synthase
TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (4/4) LD-carboxypeptidase C-terminal domain
PF13378 (4/4) Enolase C-terminal domain-like
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02016 (4/4) LD-carboxypeptidase N-terminal domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01380 (4/4) SIS domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (4/4) ABC transporter
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF12831 (3/4) FAD dependent oxidoreductase
PF07883 (3/4) Cupin domain
PF07690 (3/4) Major Facilitator Superfamily
PF02515 (3/4) CoA-transferase family III
PF01381 (3/4) Helix-turn-helix
PF00701 (3/4) Dihydrodipicolinate synthetase family
PF00378 (3/4) Enoyl-CoA hydratase/isomerase
PF00171 (3/4) Aldehyde dehydrogenase family
jaccard_groups_29 162.56 +- 163.90 7 0 0 0 0.03 +- 0.04 7 1

PF00583 (7/7) Acetyltransferase (GNAT) family
jaccard_groups_349 258.00 +- 0.00 2 0 0 0 0.01 +- 0.01 2 5

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (1/2) Polysaccharide deacetylase
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01145 (1/2) SPFH domain / Band 7 family
PF00877 (1/2) NlpC/P60 family
jaccard_groups_178 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
jaccard_groups_3030 124.21 +- 42.94 2 0 2 0 0.06 +- 0.06 2 13

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01756 (2/2) Acyl-CoA oxidase
PF00550 (2/2) Phosphopantetheine attachment site
PF00294 (2/2) pfkB family carbohydrate kinase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12840 (1/2) Helix-turn-helix domain
PF10400 (1/2) Virulence activator alpha C-term
PF03551 (1/2) Transcriptional regulator PadR-like family
PF01497 (1/2) Periplasmic binding protein
PF00005 (1/2) ABC transporter
jaccard_groups_1341 234.18 +- 83.20 3 0 0 0 0.08 +- 0.09 3 11

TIGR01234 (3/3) ribulokinase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF11762 (3/3) L-arabinose isomerase C-terminal domain
PF06964 (3/3) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (3/3) L-arabinose isomerase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF18029 (2/3) Glyoxalase-like domain
jaccard_groups_1268 97.17 +- 73.63 3 0 0 0 0.05 +- 0.04 3 6

PF00106 (3/3) short chain dehydrogenase
PF12833 (2/3) Helix-turn-helix domain
PF12625 (2/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/3) mttA/Hcf106 family
PF00743 (2/3) Flavin-binding monooxygenase-like
PF00171 (2/3) Aldehyde dehydrogenase family
jaccard_groups_5131 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
jaccard_groups_6119 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family
jaccard_groups_3009 387.00 +- 271.72 2 0 0 2 0.04 +- 0.03 2 29

TIGR04050 (2/2) AIR synthase-related protein, MSMEG_0567 C-terminal family
TIGR04047 (2/2) glycosyltransferase, MSMEG_0565 family
TIGR04046 (2/2) flavin-dependent oxidoreductase, MSMEG_0569 family
TIGR04045 (2/2) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family
TIGR04044 (2/2) MSMEG_0572 family protein
TIGR04043 (2/2) radical SAM protein, MSMEG_0568 family
TIGR04042 (2/2) MSMEG_0570 family protein
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13439 (2/2) Glycosyltransferase Family 4
PF04909 (2/2) Amidohydrolase
PF04055 (2/2) Radical SAM superfamily
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF02635 (2/2) DsrE/DsrF-like family
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00534 (2/2) Glycosyl transferases group 1
TIGR01910 (1/2) peptidase, ArgE/DapE family
PF18029 (1/2) Glyoxalase-like domain
PF16990 (1/2) Carbohydrate binding module (family 35)
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01546 (1/2) Peptidase family M20/M25/M40
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_3413 260.72 +- 115.49 7 0 0 0 0.01 +- 0.01 7 5

TIGR02532 (7/7) prepilin-type N-terminal cleavage/methylation domain
PF07963 (7/7) Prokaryotic N-terminal methylation motif
PF06750 (7/7) Bacterial Peptidase A24 N-terminal domain
PF03551 (7/7) Transcriptional regulator PadR-like family
PF01478 (7/7) Type IV leader peptidase family
jaccard_groups_4315 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
jaccard_groups_3003 1355.01 +- 1011.49 7 0 6 0 0.03 +- 0.08 7 10

PF13622 (7/7) Thioesterase-like superfamily
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00487 (7/7) Fatty acid desaturase
PF00301 (7/7) Rubredoxin
PF00067 (7/7) Cytochrome P450
PF07690 (6/7) Major Facilitator Superfamily
PF12146 (5/7) Serine aminopeptidase, S33
PF12679 (4/7) ABC-2 family transporter protein
PF00005 (4/7) ABC transporter
jaccard_groups_6202 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_537 40.72 +- 12.05 2 0 0 0 0.06 +- 0.14 2 6

PF13641 (2/2) Glycosyltransferase like family 2
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF18616 (1/2) CDI immunity proteins
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3091 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
jaccard_groups_533 69.67 +- 7.31 3 0 0 0 0.03 +- 0.03 3 2

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (2/3) Cytochrome P450
jaccard_groups_4218 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
jaccard_groups_538 717.07 +- 434.19 8 0 0 0 0.03 +- 0.03 8 5

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF08402 (8/8) TOBE domain
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF00962 (4/8) Adenosine/AMP deaminase
jaccard_groups_17 103.93 +- 69.03 9 0 0 1 0.04 +- 0.05 9 2

PF07702 (9/9) UTRA domain
PF00392 (9/9) Bacterial regulatory proteins, gntR family
jaccard_groups_459 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold
jaccard_groups_755 275.25 +- 17.25 2 0 1 0 0.01 +- 0.00 2 10

TIGR00231 (2/2) small GTP-binding protein domain
PF14492 (2/2) Elongation Factor G, domain II
PF03764 (2/2) Elongation factor G, domain IV
PF00679 (2/2) Elongation factor G C-terminus
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF16864 (1/2) Dimerisation domain
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF01494 (1/2) FAD binding domain
PF00891 (1/2) O-methyltransferase domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_1869 365.99 +- 130.08 14 0 8 0 0.06 +- 0.03 14 18

PF13561 (14/14) Enoyl-(Acyl carrier protein) reductase
PF08545 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (14/14) Beta-ketoacyl synthase, C-terminal domain
PF00378 (14/14) Enoyl-CoA hydratase/isomerase
PF00109 (14/14) Beta-ketoacyl synthase, N-terminal domain
PF00106 (14/14) short chain dehydrogenase
TIGR00976 (13/14) hydrolase CocE/NonD family protein
PF13193 (13/14) AMP-binding enzyme C-terminal domain
PF08530 (13/14) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (13/14) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (13/14) Coenzyme A transferase
PF00501 (13/14) AMP-binding enzyme
PF00196 (13/14) Bacterial regulatory proteins, luxR family
PF00005 (13/14) ABC transporter
PF04909 (12/14) Amidohydrolase
PF12679 (10/14) ABC-2 family transporter protein
PF12697 (9/14) Alpha/beta hydrolase family
jaccard_groups_128 110.12 +- 103.02 10 0 2 0 0.04 +- 0.05 10 1

PF01872 (10/10) RibD C-terminal domain
jaccard_groups_127 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6
jaccard_groups_2734 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_2138 57.64 +- 2.36 2 0 0 0 0.07 +- 0.09 2 4

PF04203 (2/2) Sortase domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
jaccard_groups_122 269.82 +- 196.36 3 0 0 0 0.04 +- 0.06 3 2

PF11706 (3/3) CGNR zinc finger
PF07336 (3/3) Putative stress-induced transcription regulator
jaccard_groups_4359 73.12 +- 24.38 2 0 0 0 0.03 +- 0.02 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein
jaccard_groups_1295 60.20 +- 25.80 2 0 0 0 0.03 +- 0.04 2 3

PF04231 (2/2) Endonuclease I
PF11239 (1/2) Protein of unknown function (DUF3040)
PF10706 (1/2) Aminoglycoside-2''-adenylyltransferase
jaccard_groups_2927 622.29 +- 125.90 3 0 3 0 0.01 +- 0.02 3 9

TIGR01250 (3/3) proline-specific peptidase
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (3/3) B12 binding domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
jaccard_groups_1740 228.06 +- 94.91 4 0 0 0 0.06 +- 0.09 4 14

PF18565 (4/4) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (4/4) Domain of unknown function (DUF4982)
PF14310 (4/4) Fibronectin type III-like domain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00703 (4/4) Glycosyl hydrolases family 2
PF17390 (3/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/4) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/4) alpha/beta hydrolase fold
PF05592 (3/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain
jaccard_groups_1465 83.73 +- 28.80 3 0 0 0 0.05 +- 0.05 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00501 (3/3) AMP-binding enzyme
jaccard_groups_984 274.59 +- 266.03 15 0 0 14 0.03 +- 0.05 15 3

PF07690 (15/15) Major Facilitator Superfamily
PF04055 (14/15) Radical SAM superfamily
PF13649 (11/15) Methyltransferase domain
jaccard_groups_3631 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_150 137.60 +- 34.40 2 0 0 0 0.02 +- 0.01 2 3

PF04672 (2/2) S-adenosyl methyltransferase
TIGR03296 (1/2) M6 family metalloprotease domain
PF13649 (1/2) Methyltransferase domain
jaccard_groups_5491 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
jaccard_groups_2218 454.73 +- 318.28 6 0 0 0 0.05 +- 0.08 6 7

PF13411 (6/6) MerR HTH family regulatory protein
PF07739 (6/6) TipAS antibiotic-recognition domain
PF03033 (6/6) Glycosyltransferase family 28 N-terminal domain
PF01551 (6/6) Peptidase family M23
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF00005 (6/6) ABC transporter
PF12679 (5/6) ABC-2 family transporter protein
jaccard_groups_2357 138.29 +- 11.26 2 0 2 0 0.06 +- 0.16 2 22

TIGR02412 (2/2) aminopeptidase N
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (2/2) ERAP1-like C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02274 (2/2) Amidinotransferase
PF01433 (2/2) Peptidase family M1 domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00550 (2/2) Phosphopantetheine attachment site
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03466 (1/2) LysR substrate binding domain
PF02195 (1/2) ParB-like nuclease domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_5496 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
jaccard_groups_2608 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region
jaccard_groups_393 101.79 +- 64.37 20 0 0 0 0.03 +- 0.02 20 3

PF12833 (20/20) Helix-turn-helix domain
PF02311 (20/20) AraC-like ligand binding domain
PF00150 (19/20) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_2851 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
jaccard_groups_2323 87.16 +- 61.05 3 0 0 0 0.04 +- 0.08 3 4

PF03965 (3/3) Penicillinase repressor
PF01435 (3/3) Peptidase family M48
PF00403 (3/3) Heavy-metal-associated domain
PF00877 (2/3) NlpC/P60 family
jaccard_groups_2321 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
jaccard_groups_1046 301.58 +- 214.44 4 0 4 4 0.07 +- 0.15 4 13

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (4/4) Lanthionine synthetase C-like protein
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
TIGR03558 (2/4) luciferase family oxidoreductase, group 1
PF13649 (2/4) Methyltransferase domain
PF01292 (2/4) Prokaryotic cytochrome b561
PF00196 (2/4) Bacterial regulatory proteins, luxR family
PF00188 (2/4) Cysteine-rich secretory protein family
PF00174 (2/4) Oxidoreductase molybdopterin binding domain
PF00072 (2/4) Response regulator receiver domain
jaccard_groups_1045 608.93 +- 519.61 5 0 4 1 0.03 +- 0.05 5 11

TIGR03945 (5/5) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (5/5) amino acid adenylation domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
TIGR03944 (4/5) 2,3-diaminopropionate biosynthesis protein SbnB
PF00975 (4/5) Thioesterase domain
PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (3/5) Condensation domain
jaccard_groups_628 28.77 +- 5.25 10 0 3 0 0.07 +- 0.09 10 6

PF13244 (10/10) Domain of unknown function (DUF4040)
PF04066 (10/10) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (10/10) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (10/10) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (10/10) Proton-conducting membrane transporter
PF12840 (9/10) Helix-turn-helix domain
jaccard_groups_2516 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat
jaccard_groups_302 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_300 2363.38 +- 2722.61 59 9 49 59 0.03 +- 0.08 50 9

TIGR03882 (59/59) bacteriocin biosynthesis cyclodehydratase domain
PF02624 (59/59) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR03604 (58/59) thiazole/oxazole-forming peptide maturase, SagD family component
PF00881 (58/59) Nitroreductase family
PF14028 (57/59) Lantibiotic biosynthesis dehydratase C-term
PF00005 (41/59) ABC transporter
PF04738 (40/59) Lantibiotic dehydratase, N terminus
PF01061 (33/59) ABC-2 type transporter
TIGR03605 (30/59) SagB-type dehydrogenase domain
jaccard_groups_78 154.21 +- 58.34 3 0 0 0 0.07 +- 0.05 3 5

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF17831 (2/3) Pyruvate dehydrogenase E1 component middle domain
PF00456 (2/3) Transketolase, thiamine diphosphate binding domain
PF00266 (2/3) Aminotransferase class-V
jaccard_groups_5672 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_73 411.67 +- 186.38 3 0 2 1 0.03 +- 0.03 3 3

PF01061 (3/3) ABC-2 type transporter
PF00005 (3/3) ABC transporter
PF00082 (2/3) Subtilase family
jaccard_groups_4270 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
jaccard_groups_76 709.50 +- 322.50 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
TIGR03296 (1/2) M6 family metalloprotease domain
PF07158 (1/2) Dicarboxylate carrier protein MatC N-terminus
PF01471 (1/2) Putative peptidoglycan binding domain
PF00939 (1/2) Sodium:sulfate symporter transmembrane region
PF00293 (1/2) NUDIX domain
jaccard_groups_4274 118.18 +- 51.61 4 0 0 0 0.04 +- 0.03 4 9

PF13377 (4/4) Periplasmic binding protein-like domain
PF08124 (4/4) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (4/4) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (4/4) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF17291 (3/4) N-terminal domain of M60-like peptidases
PF13402 (3/4) Peptidase M60, enhancin and enhancin-like
PF10022 (3/4) Uncharacterized protein conserved in bacteria (DUF2264)
PF02826 (3/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_4730 915.56 +- 502.62 2 0 0 0 0.01 +- 0.01 2 8

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_4301 275.37 +- 49.63 2 0 0 0 0.02 +- 0.02 2 8

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16884 (2/2) N-terminal domain of oxidoreductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_5373 133.61 +- 63.96 2 0 2 0 0.09 +- 0.20 2 22

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16864 (2/2) Dimerisation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF04389 (2/2) Peptidase family M28
PF03621 (2/2) MbtH-like protein
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13847 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00067 (1/2) Cytochrome P450
jaccard_groups_4878 1332.86 +- 227.14 2 0 1 0 0.01 +- 0.01 2 11

TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (2/2) dihydroorotate dehydrogenase family protein
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF09084 (2/2) NMT1/THI5 like
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF00589 (1/2) Phage integrase family
jaccard_groups_1228 327.66 +- 69.66 2 0 0 0 0.02 +- 0.02 2 7

PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF13407 (1/2) Periplasmic binding protein domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00005 (1/2) ABC transporter
jaccard_groups_5078 303.16 +- 34.84 2 0 0 0 0.06 +- 0.10 2 19

TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (2/2) Fibronectin type III-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (2/2) Peptidase_C39 like family
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF03547 (2/2) Membrane transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_3743 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family
jaccard_groups_1223 173.25 +- 198.69 8 0 4 0 0.05 +- 0.09 8 6

PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (8/8) BFD-like [2Fe-2S] binding domain
PF02782 (8/8) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (8/8) FAD dependent oxidoreductase
PF00370 (8/8) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (5/8) NUDIX domain
jaccard_groups_5175 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
jaccard_groups_4575 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_5088 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain
jaccard_groups_3228 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
jaccard_groups_278 125.60 +- 103.73 2 0 0 0 0.06 +- 0.13 2 4

PF03965 (2/2) Penicillinase repressor
PF01435 (2/2) Peptidase family M48
PF08241 (1/2) Methyltransferase domain
PF00149 (1/2) Calcineurin-like phosphoesterase
jaccard_groups_1313 119.65 +- 40.51 2 0 0 0 0.08 +- 0.07 2 15

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF04199 (2/2) Putative cyclase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
TIGR01780 (1/2) succinate-semialdehyde dehydrogenase
PF12802 (1/2) MarR family
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF04909 (1/2) Amidohydrolase
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01614 (1/2) Bacterial transcriptional regulator
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_418 88.83 +- 41.22 3 0 2 0 0.03 +- 0.04 3 4

PF08031 (3/3) Berberine and berberine like
PF01565 (3/3) FAD binding domain
PF08386 (2/3) TAP-like protein
PF00561 (2/3) alpha/beta hydrolase fold
jaccard_groups_413 197.80 +- 88.43 4 0 0 0 0.02 +- 0.01 4 4

PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
PF00754 (3/4) F5/8 type C domain
PF01120 (2/4) Alpha-L-fucosidase
jaccard_groups_2173 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
jaccard_groups_6027 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
jaccard_groups_2106 429.44 +- 25.56 2 0 2 0 0.04 +- 0.04 2 26

TIGR01733 (2/2) amino acid adenylation domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF14518 (2/2) Iron-containing redox enzyme
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF03417 (2/2) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01266 (2/2) FAD dependent oxidoreductase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
PF18563 (1/2) TubC N-terminal docking domain
jaccard_groups_3592 383.81 +- 168.05 5 0 0 5 0.01 +- 0.03 5 7

TIGR00702 (5/5) YcaO-type kinase domain
PF18029 (5/5) Glyoxalase-like domain
PF13489 (5/5) Methyltransferase domain
PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (5/5) TfuA-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
jaccard_groups_2688 97.38 +- 49.07 3 0 0 0 0.05 +- 0.06 3 8

TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/3) Glycosyl hydrolase family 92
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00553 (3/3) Cellulose binding domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF03067 (2/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
jaccard_groups_663 58.05 +- 5.27 3 0 0 0 0.05 +- 0.03 3 5

PF02386 (3/3) Cation transport protein
PF02254 (3/3) TrkA-N domain
PF02080 (3/3) TrkA-C domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF00501 (2/3) AMP-binding enzyme
jaccard_groups_2081 128.66 +- 34.98 4 0 0 0 0.02 +- 0.03 4 4

PF07690 (4/4) Major Facilitator Superfamily
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF13302 (2/4) Acetyltransferase (GNAT) domain
PF01255 (2/4) Putative undecaprenyl diphosphate synthase
jaccard_groups_3774 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_110 228.87 +- 47.17 10 0 0 0 0.01 +- 0.01 10 3

PF13545 (10/10) Crp-like helix-turn-helix domain
PF00027 (10/10) Cyclic nucleotide-binding domain
PF07228 (9/10) Stage II sporulation protein E (SpoIIE)
jaccard_groups_111 356.38 +- 193.33 3 0 3 0 0.02 +- 0.04 3 10

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily
PF00561 (2/3) alpha/beta hydrolase fold
PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_2312 383.41 +- 360.05 8 0 1 0 0.06 +- 0.07 8 10

TIGR00976 (8/8) hydrolase CocE/NonD family protein
PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
TIGR01726 (7/8) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00583 (7/8) Acetyltransferase (GNAT) family
PF00497 (7/8) Bacterial extracellular solute-binding proteins, family 3
PF01244 (6/8) Membrane dipeptidase (Peptidase family M19)
PF00296 (4/8) Luciferase-like monooxygenase
jaccard_groups_119 480.00 +- 547.55 31 8 23 31 0.02 +- 0.03 23 5

TIGR03891 (31/31) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (31/31) Lantibiotic biosynthesis dehydratase C-term
PF05147 (31/31) Lanthionine synthetase C-like protein
PF04738 (30/31) Lantibiotic dehydratase, N terminus
PF00005 (17/31) ABC transporter
jaccard_groups_2955 2158.41 +- 761.00 8 0 1 0 0.01 +- 0.01 8 12

PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF05193 (8/8) Peptidase M16 inactive domain
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (8/8) Insulinase (Peptidase family M16)
PF00005 (8/8) ABC transporter
PF17874 (7/8) MalT-like TPR region
jaccard_groups_2817 415.68 +- 202.70 2 0 0 2 0.03 +- 0.02 2 12

TIGR04469 (2/2) CGA synthase-related protein
TIGR04468 (2/2) arginine 2,3-aminomutase
TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (2/2) cytosylglucuronate decarboxylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF08241 (2/2) Methyltransferase domain
PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF07690 (1/2) Major Facilitator Superfamily
PF01433 (1/2) Peptidase family M1 domain
PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_2774 885.57 +- 176.07 4 0 1 0 0.01 +- 0.01 4 9

TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (4/4) Major Facilitator Superfamily
PF03737 (4/4) Aldolase/RraA
PF03466 (4/4) LysR substrate binding domain
PF01361 (4/4) Tautomerase enzyme
PF00994 (4/4) Probable molybdopterin binding domain
PF00682 (4/4) HMGL-like
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1554 114.67 +- 64.87 3 0 1 0 0.06 +- 0.04 3 8

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF14864 (2/3) Alkyl sulfatase C-terminal
PF14863 (2/3) Alkyl sulfatase dimerisation
PF00753 (2/3) Metallo-beta-lactamase superfamily
jaccard_groups_1000 306.75 +- 209.25 2 0 0 0 0.02 +- 0.02 2 8

PF13466 (2/2) STAS domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02607 (2/2) B12 binding domain
PF02310 (2/2) B12 binding domain
PF08031 (1/2) Berberine and berberine like
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01565 (1/2) FAD binding domain
PF00239 (1/2) Resolvase, N terminal domain
jaccard_groups_5850 977.21 +- 452.79 2 0 2 2 0.01 +- 0.02 2 25

TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (2/2) mycofactocin precursor
TIGR03967 (2/2) putative mycofactocin binding protein MftB
TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (2/2) mycofactocin system glycosyltransferase
TIGR03964 (2/2) mycofactocin system creatininase family protein
TIGR03962 (2/2) mycofactocin radical SAM maturase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF08242 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF03129 (2/2) Anticodon binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF01070 (2/2) FMN-dependent dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00535 (2/2) Glycosyl transferase family 2
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
jaccard_groups_4050 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
jaccard_groups_3817 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
jaccard_groups_3702 392.52 +- 261.55 4 0 1 0 0.04 +- 0.08 4 17

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR00802 (4/4) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (4/4) GYF domain 2
PF13421 (4/4) SPFH domain-Band 7 family
PF08281 (4/4) Sigma-70, region 4
PF07690 (4/4) Major Facilitator Superfamily
PF04542 (4/4) Sigma-70 region 2
PF04314 (4/4) Copper chaperone PCu(A)C
PF03824 (4/4) High-affinity nickel-transport protein
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00403 (4/4) Heavy-metal-associated domain
PF00122 (4/4) E1-E2 ATPase
PF13738 (3/4) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (3/4) FMN-dependent dehydrogenase
PF00067 (3/4) Cytochrome P450
PF05118 (2/4) Aspartyl/Asparaginyl beta-hydroxylase
jaccard_groups_3700 32.13 +- 5.78 3 0 0 0 0.06 +- 0.11 3 6

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF08386 (3/3) TAP-like protein
PF04149 (3/3) Domain of unknown function (DUF397)
PF02388 (3/3) FemAB family
PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_3813 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_2652 3474.49 +- 3174.88 2 0 0 0 0.04 +- 0.05 2 27

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (2/2) Prolyl oligopeptidase family
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
PF17853 (1/2) GGDEF-like domain
PF13354 (1/2) Beta-lactamase enzyme family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10400 (1/2) Virulence activator alpha C-term
PF08667 (1/2) BetR domain
PF07969 (1/2) Amidohydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF03551 (1/2) Transcriptional regulator PadR-like family
PF03061 (1/2) Thioesterase superfamily
PF02687 (1/2) FtsX-like permease family
PF01381 (1/2) Helix-turn-helix
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00501 (1/2) AMP-binding enzyme
jaccard_groups_3955 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
jaccard_groups_2498 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family
jaccard_groups_2553 191.56 +- 72.66 4 0 0 0 0.07 +- 0.11 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
jaccard_groups_1197 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_2227 192.59 +- 95.33 3 0 0 0 0.02 +- 0.05 3 4

PF11303 (3/3) Protein of unknown function (DUF3105)
PF09286 (3/3) Pro-kumamolisin, activation domain
PF03713 (3/3) Domain of unknown function (DUF305)
PF00082 (3/3) Subtilase family
jaccard_groups_4625 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_1074 32.50 +- 0.00 2 0 0 0 0.06 +- 0.05 2 2

TIGR03296 (2/2) M6 family metalloprotease domain
PF01070 (2/2) FMN-dependent dehydrogenase
jaccard_groups_182 651.51 +- 518.49 2 0 0 0 0.05 +- 0.06 2 16

PF14310 (2/2) Fibronectin type III-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13802 (1/2) Galactose mutarotase-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (1/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF01055 (1/2) Glycosyl hydrolases family 31
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_231 111.41 +- 17.59 2 0 1 0 0.04 +- 0.06 2 9

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF01965 (2/2) DJ-1/PfpI family
PF00754 (2/2) F5/8 type C domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00857 (1/2) Isochorismatase family
jaccard_groups_230 182.88 +- 297.22 81 27 52 81 0.04 +- 0.03 54 3

PF13471 (81/81) Transglutaminase-like superfamily
PF00733 (80/81) Asparagine synthase
PF05402 (69/81) Coenzyme PQQ synthesis protein D (PqqD)
jaccard_groups_2429 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal
jaccard_groups_87 52.38 +- 14.29 14 0 2 0 0.07 +- 0.08 14 5

PF03450 (14/14) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (14/14) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (14/14) [2Fe-2S] binding domain
PF01315 (14/14) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (14/14) FAD binding domain in molybdopterin dehydrogenase
jaccard_groups_3255 414.64 +- 27.64 2 0 0 0 0.01 +- 0.00 2 3

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase
jaccard_groups_36 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
jaccard_groups_37 81.97 +- 63.87 3 0 0 0 0.04 +- 0.05 3 1

PF00106 (3/3) short chain dehydrogenase
jaccard_groups_34 791.63 +- 421.13 9 0 1 1 0.03 +- 0.11 9 5

TIGR01727 (9/9) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (9/9) ABC transporter
jaccard_groups_681 119.17 +- 54.17 2 0 1 0 0.03 +- 0.02 2 6

PF00754 (2/2) F5/8 type C domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14099 (1/2) Polysaccharide lyase
PF04616 (1/2) Glycosyl hydrolases family 43
PF01120 (1/2) Alpha-L-fucosidase
PF00082 (1/2) Subtilase family
jaccard_groups_30 545.83 +- 791.07 15 0 15 1 0.03 +- 0.09 15 6

TIGR01733 (15/15) amino acid adenylation domain
PF13193 (15/15) AMP-binding enzyme C-terminal domain
PF00668 (15/15) Condensation domain
PF00550 (15/15) Phosphopantetheine attachment site
PF00501 (15/15) AMP-binding enzyme
PF00975 (12/15) Thioesterase domain
jaccard_groups_31 170.84 +- 87.16 2 0 1 0 0.05 +- 0.09 2 3

PF00067 (2/2) Cytochrome P450
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01427 (1/2) D-ala-D-ala dipeptidase
jaccard_groups_39 108.86 +- 77.01 24 0 2 0 0.03 +- 0.04 24 2

PF00561 (24/24) alpha/beta hydrolase fold
PF08386 (16/24) TAP-like protein
jaccard_groups_849 81.64 +- 74.60 8 0 0 0 0.05 +- 0.05 8 2

PF01874 (8/8) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (8/8) Dioxygenase
jaccard_groups_334 104.13 +- 69.20 2 0 0 0 0.08 +- 0.16 2 6

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin
jaccard_groups_333 132.81 +- 14.62 2 0 0 0 0.03 +- 0.04 2 5

PF01738 (2/2) Dienelactone hydrolase family
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00156 (1/2) Phosphoribosyl transferase domain
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
jaccard_groups_1216 123.93 +- 11.86 2 0 1 0 0.04 +- 0.05 2 11

PF04444 (2/2) Catechol dioxygenase N terminus
PF00775 (2/2) Dioxygenase
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF14525 (1/2) AraC-binding-like domain
PF12833 (1/2) Helix-turn-helix domain
PF07730 (1/2) Histidine kinase
PF03466 (1/2) LysR substrate binding domain
PF01494 (1/2) FAD binding domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (1/2) Response regulator receiver domain
jaccard_groups_4801 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
jaccard_groups_6262 523.42 +- 54.35 2 0 2 2 0.05 +- 0.08 2 18

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13575 (2/2) Domain of unknown function (DUF4135)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00664 (2/2) ABC transporter transmembrane region
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07366 (1/2) SnoaL-like polyketide cyclase
jaccard_groups_3405 505.11 +- 323.47 3 0 0 0 0.03 +- 0.09 3 12

TIGR00556 (3/3) phosphopantetheine--protein transferase domain
TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF12706 (3/3) Beta-lactamase superfamily domain
PF11583 (3/3) P-aminobenzoate N-oxygenase AurF
PF07690 (3/3) Major Facilitator Superfamily
PF06628 (3/3) Catalase-related immune-responsive
PF04072 (3/3) Leucine carboxyl methyltransferase
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01575 (3/3) MaoC like domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00199 (3/3) Catalase
PF09947 (2/3) Uncharacterized protein conserved in archaea (DUF2180)
jaccard_groups_337 205.76 +- 106.24 2 0 0 0 0.06 +- 0.13 2 8

PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
TIGR02462 (1/2) pyranose oxidase
PF12902 (1/2) Ferritin-like
PF07690 (1/2) Major Facilitator Superfamily
PF03928 (1/2) Haem-degrading
PF01551 (1/2) Peptidase family M23
PF01471 (1/2) Putative peptidoglycan binding domain
jaccard_groups_6471 545.32 +- 29.32 2 0 0 0 0.01 +- 0.00 2 9

PF04199 (2/2) Putative cyclase
PF02728 (2/2) Copper amine oxidase, N3 domain
PF01179 (2/2) Copper amine oxidase, enzyme domain
PF01019 (2/2) Gamma-glutamyltranspeptidase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
jaccard_groups_529 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
jaccard_groups_247 426.40 +- 283.00 8 2 6 8 0.02 +- 0.05 6 11

TIGR03897 (8/8) type 2 lantibiotic biosynthesis protein LanM
PF13575 (8/8) Domain of unknown function (DUF4135)
PF05147 (8/8) Lanthionine synthetase C-like protein
PF03704 (6/8) Bacterial transcriptional activator domain
PF00486 (6/8) Transcriptional regulatory protein, C terminal
PF13191 (5/8) AAA ATPase domain
PF00931 (5/8) NB-ARC domain
PF00196 (5/8) Bacterial regulatory proteins, luxR family
PF13185 (4/8) GAF domain
PF08448 (4/8) PAS fold
PF07228 (4/8) Stage II sporulation protein E (SpoIIE)
jaccard_groups_428 50.92 +- 20.56 4 0 1 0 0.06 +- 0.05 4 3

PF00174 (4/4) Oxidoreductase molybdopterin binding domain
PF01292 (3/4) Prokaryotic cytochrome b561
PF07519 (2/4) Tannase and feruloyl esterase
jaccard_groups_740 91.14 +- 8.59 3 0 0 0 0.03 +- 0.04 3 4

PF13480 (3/3) Acetyltransferase (GNAT) domain
PF02156 (3/3) Glycosyl hydrolase family 26
PF01522 (3/3) Polysaccharide deacetylase
PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_2136 953.88 +- 214.88 6 2 0 6 0.01 +- 0.01 4 7

TIGR04085 (6/6) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (6/6) Iron-sulfur cluster-binding domain
PF05402 (6/6) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (6/6) Radical SAM superfamily
PF00005 (6/6) ABC transporter
PF01061 (4/6) ABC-2 type transporter
PF00717 (4/6) Peptidase S24-like
jaccard_groups_1286 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_6065 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_1283 491.11 +- 40.86 3 0 0 0 0.01 +- 0.00 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF18029 (2/3) Glyoxalase-like domain
PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_2911 759.98 +- 690.09 3 0 3 3 0.06 +- 0.20 3 6

PF06114 (3/3) IrrE N-terminal-like domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
jaccard_groups_1296 478.51 +- 301.49 2 0 2 0 0.03 +- 0.05 2 16

PF14765 (2/2) Polyketide synthase dehydratase
PF13489 (2/2) Methyltransferase domain
PF08659 (2/2) KR domain
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01426 (1/2) glycosyltransferase, MGT family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF12146 (1/2) Serine aminopeptidase, S33
PF07859 (1/2) alpha/beta hydrolase fold
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_2148 178.59 +- 147.68 3 0 0 0 0.04 +- 0.04 3 3

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (3/3) Cytochrome P450
PF03745 (2/3) Domain of unknown function (DUF309)
jaccard_groups_6081 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_3628 2401.56 +- 1135.16 3 0 0 0 0.02 +- 0.01 3 13

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (3/3) ATP-grasp domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01613 (3/3) Flavin reductase like domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00106 (3/3) short chain dehydrogenase
PF18130 (2/3) ATP-grasp N-terminal domain
jaccard_groups_142 126.17 +- 68.83 2 0 0 0 0.03 +- 0.04 2 4

PF04978 (2/2) Protein of unknown function (DUF664)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF03795 (1/2) YCII-related domain
PF01636 (1/2) Phosphotransferase enzyme family
jaccard_groups_145 388.16 +- 408.77 6 0 0 0 0.05 +- 0.11 6 7

PF13407 (6/6) Periplasmic binding protein domain
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF00005 (6/6) ABC transporter
PF13377 (5/6) Periplasmic binding protein-like domain
PF00356 (5/6) Bacterial regulatory proteins, lacI family
PF00294 (5/6) pfkB family carbohydrate kinase
PF05025 (4/6) RbsD / FucU transport protein family
jaccard_groups_6059 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
jaccard_groups_2269 155.79 +- 11.35 2 0 2 0 0.03 +- 0.07 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF07690 (2/2) Major Facilitator Superfamily
PF01361 (2/2) Tautomerase enzyme
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF17645 (1/2) Arylmalonate decarboxylase
PF14681 (1/2) Uracil phosphoribosyltransferase
PF14027 (1/2) Questin oxidase-like
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF11695 (1/2) Domain of unknown function (DUF3291)
PF08962 (1/2) Domain of unknown function (DUF1876)
PF08386 (1/2) TAP-like protein
PF04227 (1/2) Indigoidine synthase A like protein
PF00561 (1/2) alpha/beta hydrolase fold
PF00144 (1/2) Beta-lactamase
jaccard_groups_2348 481.99 +- 169.64 10 0 10 0 0.02 +- 0.01 10 14

TIGR01850 (10/10) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (10/10) alpha-L-glutamate ligase, RimK family
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF08443 (10/10) RimK-like ATP-grasp domain
PF02780 (10/10) Transketolase, C-terminal domain
PF02779 (10/10) Transketolase, pyrimidine binding domain
PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain
PF01118 (10/10) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (10/10) AMP-binding enzyme
PF00456 (10/10) Transketolase, thiamine diphosphate binding domain
PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (9/10) LysR substrate binding domain
PF00126 (9/10) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_2263 133.48 +- 31.64 2 0 0 0 0.04 +- 0.04 2 6

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
jaccard_groups_4149 75.88 +- 0.00 2 0 0 2 0.07 +- 0.07 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_1913 91.36 +- 15.97 3 0 0 0 0.06 +- 0.11 3 8

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF00717 (3/3) Peptidase S24-like
PF00501 (3/3) AMP-binding enzyme
PF00092 (3/3) von Willebrand factor type A domain
PF00005 (3/3) ABC transporter
jaccard_groups_1527 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain
jaccard_groups_4412 1472.40 +- 491.27 3 0 0 0 0.01 +- 0.01 3 17

TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (3/3) Enolase C-terminal domain-like
PF13183 (3/3) 4Fe-4S dicluster domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (3/3) FCD domain
PF03737 (3/3) Aldolase/RraA
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (3/3) FAD binding domain
PF01229 (3/3) Glycosyl hydrolases family 39
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter
jaccard_groups_4066 107.65 +- 48.04 3 0 0 0 0.07 +- 0.07 3 5

PF01427 (3/3) D-ala-D-ala dipeptidase
PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
PF01425 (2/3) Amidase
PF00069 (2/3) Protein kinase domain
jaccard_groups_5801 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_2297 226.23 +- 76.62 10 0 0 0 0.05 +- 0.04 10 10

TIGR00976 (10/10) hydrolase CocE/NonD family protein
PF08530 (10/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (10/10) alpha/beta hydrolase fold
PF02129 (10/10) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (10/10) Phosphotriesterase family
PF01494 (10/10) FAD binding domain
PF00753 (10/10) Metallo-beta-lactamase superfamily
PF07690 (9/10) Major Facilitator Superfamily
PF03781 (9/10) Sulfatase-modifying factor enzyme 1
PF00884 (9/10) Sulfatase
jaccard_groups_4385 113.39 +- 34.95 4 0 0 0 0.06 +- 0.10 4 7

PF13581 (4/4) Histidine kinase-like ATPase domain
PF07690 (4/4) Major Facilitator Superfamily
PF07681 (4/4) DoxX
PF02515 (4/4) CoA-transferase family III
PF01546 (4/4) Peptidase family M20/M25/M40
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (4/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_4380 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)
jaccard_groups_4068 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
jaccard_groups_3966 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
jaccard_groups_1140 593.76 +- 477.93 2 0 0 0 0.04 +- 0.08 2 15

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF17197 (2/2) Domain of unknown function (DUF5134)
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03929 (2/2) PepSY-associated TM region
PF01965 (2/2) DJ-1/PfpI family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF12833 (1/2) Helix-turn-helix domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00005 (1/2) ABC transporter
jaccard_groups_46 350.14 +- 165.86 2 0 1 0 0.02 +- 0.02 2 9

PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13714 (1/2) Phosphoenolpyruvate phosphomutase
PF13699 (1/2) Domain of unknown function (DUF4157)
PF13649 (1/2) Methyltransferase domain
PF07969 (1/2) Amidohydrolase family
PF01083 (1/2) Cutinase
PF00975 (1/2) Thioesterase domain
PF00248 (1/2) Aldo/keto reductase family
jaccard_groups_45 358.78 +- 294.16 3 0 0 0 0.01 +- 0.01 3 1

PF01494 (3/3) FAD binding domain
jaccard_groups_42 363.14 +- 500.69 11 0 1 0 0.03 +- 0.06 11 2

PF13193 (11/11) AMP-binding enzyme C-terminal domain
PF00501 (11/11) AMP-binding enzyme
jaccard_groups_4201 335.33 +- 121.62 4 0 1 0 0.04 +- 0.03 4 9

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (4/4) Periplasmic binding protein-like domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF12833 (3/4) Helix-turn-helix domain
PF01965 (3/4) DJ-1/PfpI family
jaccard_groups_1629 185.37 +- 61.16 8 0 0 0 0.09 +- 0.08 8 17

PF16875 (8/8) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (8/8) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13378 (8/8) Enolase C-terminal domain-like
PF08450 (8/8) SMP-30/Gluconolactonase/LRE-like region
PF07729 (8/8) FCD domain
PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (8/8) Melibiase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01081 (8/8) KDPG and KHG aldolase
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
PF17801 (7/8) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (7/8) Alpha galactosidase A
PF00583 (6/8) Acetyltransferase (GNAT) family
TIGR01409 (4/8) Tat (twin-arginine translocation) pathway signal sequence
jaccard_groups_4707 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
jaccard_groups_5243 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
jaccard_groups_3848 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
jaccard_groups_881 363.96 +- 245.86 3 0 0 0 0.04 +- 0.02 3 8

TIGR00126 (3/3) deoxyribose-phosphate aldolase
PF13407 (3/3) Periplasmic binding protein domain
PF07702 (3/3) UTRA domain
PF05025 (3/3) RbsD / FucU transport protein family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF02653 (2/3) Branched-chain amino acid transport system / permease component
PF00294 (2/3) pfkB family carbohydrate kinase
jaccard_groups_929 167.23 +- 13.37 2 0 0 0 0.06 +- 0.04 2 13

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00972 (2/2) phosphate ABC transporter, ATP-binding protein
PF16640 (2/2) Bacterial Ig-like domain (group 3)
PF12849 (2/2) PBP superfamily domain
PF04203 (2/2) Sortase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00041 (2/2) Fibronectin type III domain
PF00005 (2/2) ABC transporter
TIGR01076 (1/2) sortase
PF12833 (1/2) Helix-turn-helix domain
PF06719 (1/2) AraC-type transcriptional regulator N-terminus
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_567 411.00 +- 239.00 2 0 0 0 0.01 +- 0.01 2 15

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF12146 (1/2) Serine aminopeptidase, S33
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05592 (1/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01979 (1/2) Amidohydrolase family
PF01494 (1/2) FAD binding domain
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00754 (1/2) F5/8 type C domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_5347 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_158 93.07 +- 22.71 2 0 0 0 0.03 +- 0.04 2 11

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF13641 (1/2) Glycosyltransferase like family 2
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF07730 (1/2) Histidine kinase
PF07366 (1/2) SnoaL-like polyketide cyclase
PF01522 (1/2) Polysaccharide deacetylase
PF00561 (1/2) alpha/beta hydrolase fold
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00072 (1/2) Response regulator receiver domain
jaccard_groups_4964 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
jaccard_groups_4841 1530.48 +- 523.91 3 0 2 0 0.01 +- 0.03 3 14

PF05193 (3/3) Peptidase M16 inactive domain
PF01937 (3/3) Protein of unknown function DUF89
PF01326 (3/3) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (3/3) ABC-2 type transporter
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00391 (3/3) PEP-utilising enzyme, mobile domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF03965 (2/3) Penicillinase repressor
PF01475 (2/3) Ferric uptake regulator family
PF01435 (2/3) Peptidase family M48
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_4518 186.14 +- 8.86 2 0 0 0 0.03 +- 0.04 2 6

PF13564 (2/2) DoxX-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (2/2) NADPH-dependent FMN reductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF18616 (1/2) CDI immunity proteins
jaccard_groups_208 196.06 +- 138.24 10 0 0 10 0.03 +- 0.08 10 10

TIGR04269 (10/10) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (10/10) HEXXH motif domain
PF13676 (10/10) TIR domain
PF13424 (10/10) Tetratricopeptide repeat
PF13374 (10/10) Tetratricopeptide repeat
PF04055 (10/10) Radical SAM superfamily
PF00931 (8/10) NB-ARC domain
TIGR04268 (7/10) FXSXX-COOH protein
TIGR04276 (6/10) FxsC C-terminal domain
PF01656 (5/10) CobQ/CobB/MinD/ParA nucleotide binding domain
jaccard_groups_366 28.64 +- 10.40 3 0 0 0 0.09 +- 0.13 3 5

TIGR01701 (3/3) oxidoreductase alpha (molybdopterin) subunit
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
PF07077 (2/3) Protein of unknown function (DUF1345)
jaccard_groups_1996 411.81 +- 445.80 5 0 2 0 0.06 +- 0.08 5 6

TIGR01972 (5/5) proton-translocating NADH-quinone oxidoreductase, chain M
PF00507 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (5/5) Proton-conducting membrane transporter
PF00146 (5/5) NADH dehydrogenase
jaccard_groups_1363 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
jaccard_groups_1360 40.01 +- 4.56 2 0 1 0 0.06 +- 0.06 2 5

PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13191 (1/2) AAA ATPase domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_3444 218.17 +- 57.06 5 0 5 5 0.05 +- 0.06 5 9

PF08386 (5/5) TAP-like protein
PF05532 (5/5) CsbD-like
PF05147 (5/5) Lanthionine synthetase C-like protein
PF00664 (5/5) ABC transporter transmembrane region
PF00561 (5/5) alpha/beta hydrolase fold
PF00069 (5/5) Protein kinase domain
PF00005 (5/5) ABC transporter
PF12697 (4/5) Alpha/beta hydrolase family
PF00117 (3/5) Glutamine amidotransferase class-I
jaccard_groups_6222 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_777 29.90 +- 5.84 3 0 0 0 0.08 +- 0.09 3 4

PF13516 (3/3) Leucine Rich repeat
PF13203 (3/3) Putative metallopeptidase domain
PF09967 (3/3) VWA-like domain (DUF2201)
PF07728 (3/3) AAA domain (dynein-related subfamily)
jaccard_groups_772 455.00 +- 195.00 2 0 0 0 0.01 +- 0.00 2 3

PF00246 (2/2) Zinc carboxypeptidase
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF00082 (1/2) Subtilase family
jaccard_groups_3664 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
jaccard_groups_3665 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
jaccard_groups_3660 174.02 +- 47.17 5 0 0 0 0.07 +- 0.10 5 7

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF12680 (5/5) SnoaL-like domain
PF07045 (5/5) Domain of unknown function (DUF1330)
PF01738 (5/5) Dienelactone hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter
jaccard_groups_1887 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_100 283.77 +- 123.70 5 0 0 0 0.04 +- 0.06 5 2

PF17964 (5/5) Bacterial Ig domain
PF03734 (5/5) L,D-transpeptidase catalytic domain
jaccard_groups_103 26.66 +- 3.06 3 0 0 0 0.07 +- 0.07 3 3

PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00457 (2/3) Glycosyl hydrolases family 11
PF00331 (2/3) Glycosyl hydrolase family 10
jaccard_groups_102 712.17 +- 360.81 9 0 8 6 0.05 +- 0.13 9 11

TIGR03797 (9/9) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (9/9) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF03412 (9/9) Peptidase C39 family
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
PF13437 (8/9) HlyD family secretion protein
TIGR03882 (6/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (6/9) SagB-type dehydrogenase domain
TIGR03604 (6/9) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (6/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/9) Nitroreductase family
jaccard_groups_6357 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
jaccard_groups_6036 301.83 +- 85.17 2 0 0 2 0.01 +- 0.00 2 7

PF13620 (2/2) Carboxypeptidase regulatory-like domain
PF09861 (2/2) Lactate racemase N-terminal domain
PF04264 (2/2) YceI-like domain
PF00733 (2/2) Asparagine synthase
PF00731 (2/2) AIR carboxylase
PF00083 (2/2) Sugar (and other) transporter
TIGR00268 (1/2) TIGR00268 family protein
jaccard_groups_2768 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
jaccard_groups_2761 1099.00 +- 449.00 3 1 0 0 0.01 +- 0.00 2 6

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF01614 (3/3) Bacterial transcriptional regulator
PF00501 (3/3) AMP-binding enzyme
PF02515 (2/3) CoA-transferase family III
PF01144 (2/3) Coenzyme A transferase
jaccard_groups_4106 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
jaccard_groups_2827 232.15 +- 115.15 2 0 0 0 0.02 +- 0.01 2 10

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF02525 (1/2) Flavodoxin-like fold
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_470 72.96 +- 100.25 9 0 0 0 0.06 +- 0.08 9 5

PF17866 (9/9) AAA lid domain
PF13229 (9/9) Right handed beta helix region
PF00652 (9/9) Ricin-type beta-trefoil lectin domain
PF00082 (9/9) Subtilase family
PF00004 (9/9) ATPase family associated with various cellular activities (AAA)
jaccard_groups_472 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
jaccard_groups_3804 698.76 +- 460.13 3 0 0 0 0.02 +- 0.03 3 8

PF10502 (3/3) Signal peptidase, peptidase S26
PF03704 (3/3) Bacterial transcriptional activator domain
PF00931 (3/3) NB-ARC domain
PF00717 (3/3) Peptidase S24-like
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
PF07291 (2/3) Methylamine utilisation protein MauE
PF00899 (2/3) ThiF family
jaccard_groups_5425 800.15 +- 419.49 2 0 0 0 0.03 +- 0.02 2 15

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17645 (2/2) Arylmalonate decarboxylase
PF09339 (2/2) IclR helix-turn-helix domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02426 (2/2) Muconolactone delta-isomerase
PF01614 (2/2) Bacterial transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13489 (1/2) Methyltransferase domain
PF05685 (1/2) Putative restriction endonuclease
PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2234 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
jaccard_groups_4083 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase
jaccard_groups_1584 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
jaccard_groups_2239 192.15 +- 49.28 3 0 0 0 0.03 +- 0.04 3 4

TIGR01910 (3/3) peptidase, ArgE/DapE family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_4327 217.10 +- 169.90 2 0 0 0 0.04 +- 0.10 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00912 (1/2) Transglycosylase
jaccard_groups_1062 855.25 +- 692.75 2 0 1 0 0.02 +- 0.04 2 16

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13622 (1/2) Thioesterase-like superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01613 (1/2) Flavin reductase like domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00106 (1/2) short chain dehydrogenase
jaccard_groups_4424 1191.19 +- 1181.25 4 1 1 4 0.05 +- 0.18 3 22

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/4) Methyltransferase domain
PF07993 (4/4) Male sterility protein
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF03176 (4/4) MMPL family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/4) MOSC domain
PF01575 (3/4) MaoC like domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF05193 (2/4) Peptidase M16 inactive domain
PF03476 (2/4) MOSC N-terminal beta barrel domain
PF00106 (2/4) short chain dehydrogenase
jaccard_groups_1497 200.79 +- 26.57 5 0 0 0 0.07 +- 0.11 5 15

TIGR01182 (5/5) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (5/5) Domain of unknown function (DUF4380)
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13407 (5/5) Periplasmic binding protein domain
PF13378 (5/5) Enolase C-terminal domain-like
PF08450 (5/5) SMP-30/Gluconolactonase/LRE-like region
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07729 (5/5) FCD domain
PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF01081 (5/5) KDPG and KHG aldolase
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter
jaccard_groups_608 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain
jaccard_groups_601 243.14 +- 234.27 31 0 28 30 0.03 +- 0.04 31 5

PF07690 (31/31) Major Facilitator Superfamily
PF04055 (30/31) Radical SAM superfamily
PF00326 (28/31) Prolyl oligopeptidase family
PF02310 (19/31) B12 binding domain
TIGR03975 (16/31) ribosomal peptide maturation radical SAM protein 1
jaccard_groups_604 347.75 +- 199.45 6 0 1 0 0.04 +- 0.06 6 3

PF09084 (6/6) NMT1/THI5 like
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00005 (6/6) ABC transporter
jaccard_groups_1669 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
jaccard_groups_2530 151.10 +- 35.76 3 0 0 0 0.03 +- 0.03 3 6

PF07702 (3/3) UTRA domain
PF03747 (3/3) ADP-ribosylglycohydrolase
PF02133 (3/3) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF04672 (2/3) S-adenosyl methyltransferase
jaccard_groups_1943 280.13 +- 235.87 2 0 0 2 0.05 +- 0.16 2 7

PF14518 (2/2) Iron-containing redox enzyme
PF12704 (2/2) MacB-like periplasmic core domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
jaccard_groups_92 934.57 +- 552.23 6 0 1 0 0.03 +- 0.04 6 2

PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4557 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_98 355.79 +- 204.29 8 0 0 0 0.07 +- 0.20 8 11

PF00691 (8/8) OmpA family
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF13400 (7/8) Putative Flp pilus-assembly TadE/G-like
PF07730 (7/8) Histidine kinase
PF00196 (7/8) Bacterial regulatory proteins, luxR family
PF00072 (7/8) Response regulator receiver domain
TIGR03177 (6/8) Flp pilus assembly protein CpaB
PF16976 (6/8) Flp pilus assembly protein RcpC/CpaB
PF13614 (6/8) AAA domain
PF07811 (6/8) TadE-like protein
PF00437 (6/8) Type II/IV secretion system protein
jaccard_groups_99 136.23 +- 121.23 8 0 0 0 0.05 +- 0.05 8 3

PF00296 (8/8) Luciferase-like monooxygenase
PF07690 (5/8) Major Facilitator Superfamily
PF00106 (5/8) short chain dehydrogenase
jaccard_groups_4632 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
jaccard_groups_694 297.75 +- 125.22 3 0 0 3 0.02 +- 0.03 3 10

TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF12706 (3/3) Beta-lactamase superfamily domain
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
jaccard_groups_914 396.80 +- 256.32 12 0 12 0 0.06 +- 0.15 12 16

TIGR03945 (12/12) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (12/12) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (12/12) amino acid adenylation domain
PF13193 (12/12) AMP-binding enzyme C-terminal domain
PF03621 (12/12) MbtH-like protein
PF02423 (12/12) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (12/12) Thioesterase domain
PF00668 (12/12) Condensation domain
PF00550 (12/12) Phosphopantetheine attachment site
PF00501 (12/12) AMP-binding enzyme
PF00291 (12/12) Pyridoxal-phosphate dependent enzyme
TIGR01720 (11/12) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (11/12) daunorubicin resistance ABC transporter, ATP-binding protein
PF01061 (11/12) ABC-2 type transporter
PF00005 (11/12) ABC transporter
PF13732 (9/12) Domain of unknown function (DUF4162)
jaccard_groups_5629 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_3938 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
jaccard_groups_850 167.70 +- 38.70 2 0 0 0 0.01 +- 0.01 2 4

PF12802 (2/2) MarR family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00583 (2/2) Acetyltransferase (GNAT) family
PF05977 (1/2) Transmembrane secretion effector
jaccard_groups_3930 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
jaccard_groups_324 298.27 +- 161.74 5 0 1 5 0.06 +- 0.08 5 8

TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF00005 (5/5) ABC transporter
PF00664 (4/5) ABC transporter transmembrane region
PF01497 (3/5) Periplasmic binding protein
PF01032 (3/5) FecCD transport family
jaccard_groups_859 261.24 +- 116.32 4 0 4 0 0.02 +- 0.03 4 7

TIGR01746 (4/4) thioester reductase domain
PF07993 (4/4) Male sterility protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF13193 (3/4) AMP-binding enzyme C-terminal domain
PF00300 (3/4) Histidine phosphatase superfamily (branch 1)
PF00196 (3/4) Bacterial regulatory proteins, luxR family
jaccard_groups_2998 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
jaccard_groups_4951 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
jaccard_groups_1200 423.60 +- 111.96 20 0 4 0 0.05 +- 0.16 20 14

TIGR01850 (20/20) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (20/20) RimK-like ATP-grasp domain
PF02779 (20/20) Transketolase, pyrimidine binding domain
PF01118 (20/20) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (20/20) Transketolase, thiamine diphosphate binding domain
TIGR01902 (19/20) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (19/20) Peptidase family M20/M25/M40
PF01041 (19/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (19/20) Amino acid kinase family
TIGR00768 (16/20) alpha-L-glutamate ligase, RimK family
PF18603 (15/20) L-amino acid ligase C-terminal domain 2
PF18130 (15/20) ATP-grasp N-terminal domain
PF13535 (15/20) ATP-grasp domain
PF07690 (15/20) Major Facilitator Superfamily
jaccard_groups_1201 304.78 +- 169.03 5 0 0 0 0.02 +- 0.11 5 9

TIGR01554 (5/5) phage major capsid protein, HK97 family
TIGR01543 (5/5) phage prohead protease, HK97 family
TIGR01537 (5/5) phage portal protein, HK97 family
PF05065 (5/5) Phage capsid family
PF04860 (5/5) Phage portal protein
PF04586 (5/5) Caudovirus prohead serine protease
PF01844 (5/5) HNH endonuclease
PF01510 (5/5) N-acetylmuramoyl-L-alanine amidase
PF09250 (3/5) Bifunctional DNA primase/polymerase, N-terminal
jaccard_groups_5019 143.00 +- 117.00 2 0 0 0 0.04 +- 0.07 2 3

PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00931 (2/2) NB-ARC domain
jaccard_groups_5018 260.13 +- 5.78 2 0 0 0 0.02 +- 0.01 2 11

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00326 (2/2) riboflavin biosynthesis protein RibD
PF13641 (2/2) Glycosyltransferase like family 2
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (2/2) RibD C-terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
jaccard_groups_4815 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
jaccard_groups_3439 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_3436 105.42 +- 39.62 3 0 0 0 0.06 +- 0.04 3 10

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (3/3) Sigma-70, region 4
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01966 (3/3) HD domain
TIGR00778 (2/3) alkylhydroperoxidase AhpD family core domain
PF08240 (2/3) Alcohol dehydrogenase GroES-like domain
PF02627 (2/3) Carboxymuconolactone decarboxylase family
PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_823 258.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 2

PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01234 (2/2) NNMT/PNMT/TEMT family
jaccard_groups_826 124.87 +- 85.22 5 0 0 0 0.03 +- 0.03 5 5

TIGR01840 (5/5) esterase, PHB depolymerase family
TIGR00666 (5/5) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (5/5) Protein of unknown function (DUF4232)
PF10503 (5/5) Esterase PHB depolymerase
PF02113 (5/5) D-Ala-D-Ala carboxypeptidase 3 (S13) family
jaccard_groups_3322 66.72 +- 9.38 2 0 2 0 0.06 +- 0.01 2 12

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF18130 (2/2) ATP-grasp N-terminal domain
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase
jaccard_groups_559 532.21 +- 472.81 5 0 2 4 0.02 +- 0.07 5 6

TIGR03882 (4/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF07730 (3/5) Histidine kinase
PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00072 (3/5) Response regulator receiver domain
jaccard_groups_556 128.36 +- 9.29 2 0 0 0 0.03 +- 0.03 2 8

PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF00041 (2/2) Fibronectin type III domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF07944 (1/2) Beta-L-arabinofuranosidase, GH127
PF01757 (1/2) Acyltransferase family
PF00545 (1/2) ribonuclease
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_jaccard_groups_37731 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9969 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_1147 339.13 +- 0.00 2 0 0 0 0.03 +- 0.01 2 8

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_1146 328.63 +- 21.56 3 0 3 3 0.03 +- 0.03 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF01546 (3/3) Peptidase family M20/M25/M40
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_26551 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_22017 275.37 +- 49.63 2 0 0 0 0.02 +- 0.02 2 8

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16884 (2/2) N-terminal domain of oxidoreductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_41746 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_13838 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_33956 134.01 +- 78.72 2 0 2 2 0.06 +- 0.05 2 9

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat
precursor_jaccard_groups_19591 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_21824 303.16 +- 34.84 2 0 0 0 0.06 +- 0.10 2 19

TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (2/2) Fibronectin type III-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (2/2) Peptidase_C39 like family
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF03547 (2/2) Membrane transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_10625 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_541 144.49 +- 22.80 12 0 12 12 0.02 +- 0.02 12 4

PF07690 (12/12) Major Facilitator Superfamily
PF04055 (12/12) Radical SAM superfamily
PF02897 (12/12) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (12/12) Prolyl oligopeptidase family
precursor_jaccard_groups_2197 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_jaccard_groups_3842 1010.92 +- 468.30 4 0 0 4 0.03 +- 0.04 4 25

TIGR03812 (4/4) tyrosine decarboxylase MnfA
PF17755 (4/4) UvrA DNA-binding domain
PF16861 (4/4) Carbamoyltransferase C-terminus
PF16169 (4/4) Domain of unknown function (DUF4872)
PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (4/4) DNA alkylation repair enzyme
PF08241 (4/4) Methyltransferase domain
PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (4/4) Radical SAM superfamily
PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (4/4) Carbamoyltransferase N-terminus
PF02310 (4/4) B12 binding domain
PF02195 (4/4) ParB-like nuclease domain
PF01613 (4/4) Flavin reductase like domain
PF01568 (4/4) Molydopterin dinucleotide binding domain
PF01061 (4/4) ABC-2 type transporter
PF00805 (4/4) Pentapeptide repeats (8 copies)
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00384 (4/4) Molybdopterin oxidoreductase
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (4/4) ABC transporter
PF00501 (3/4) AMP-binding enzyme
precursor_jaccard_groups_21306 100.33 +- 20.27 3 0 0 0 0.02 +- 0.02 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_10192 140.89 +- 0.00 2 0 2 2 0.10 +- 0.08 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_44567 117.34 +- 48.52 2 0 2 0 0.03 +- 0.04 2 4

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_6296 122.10 +- 43.38 4 0 0 0 0.05 +- 0.04 4 12

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_30675 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_30676 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_18596 377.27 +- 142.73 2 0 0 0 0.02 +- 0.01 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_18227 763.96 +- 609.16 2 0 2 1 0.05 +- 0.14 2 24

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
precursor_jaccard_groups_35157 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_5311 552.84 +- 40.56 2 0 2 0 0.07 +- 0.18 2 28

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13279 (2/2) Thioesterase-like superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13160 (2/2) Protein of unknown function (DUF3995)
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF02310 (2/2) B12 binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_269 297.75 +- 125.22 3 0 0 3 0.02 +- 0.03 3 10

TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF12706 (3/3) Beta-lactamase superfamily domain
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
precursor_jaccard_groups_783 148.42 +- 88.47 10 0 0 10 0.03 +- 0.02 10 3

PF13649 (10/10) Methyltransferase domain
PF07690 (10/10) Major Facilitator Superfamily
PF04055 (10/10) Radical SAM superfamily
precursor_jaccard_groups_26178 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_464 1062.51 +- 1018.52 46 5 41 45 0.03 +- 0.09 41 7

TIGR03897 (45/46) type 2 lantibiotic biosynthesis protein LanM
PF13575 (45/46) Domain of unknown function (DUF4135)
PF05147 (45/46) Lanthionine synthetase C-like protein
PF03412 (45/46) Peptidase C39 family
PF00664 (45/46) ABC transporter transmembrane region
PF00005 (45/46) ABC transporter
PF14867 (41/46) Lantibiotic alpha
precursor_jaccard_groups_6724 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_jaccard_groups_19927 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_10697 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_2900 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_14447 32.13 +- 5.78 3 0 0 0 0.06 +- 0.11 3 6

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF08386 (3/3) TAP-like protein
PF04149 (3/3) Domain of unknown function (DUF397)
PF02388 (3/3) FemAB family
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_38006 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_20439 197.39 +- 31.14 3 0 0 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17446 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain
precursor_jaccard_groups_1560 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein
precursor_jaccard_groups_27278 518.00 +- 2.00 2 0 2 0 0.01 +- 0.00 2 6

PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1568 143.45 +- 42.27 2 0 2 0 0.03 +- 0.04 2 10

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF09339 (1/2) IclR helix-turn-helix domain
PF07730 (1/2) Histidine kinase
PF01636 (1/2) Phosphotransferase enzyme family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_17965 287.08 +- 232.92 2 0 2 2 0.04 +- 0.10 2 7

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_13164 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family
precursor_jaccard_groups_13300 237.00 +- 29.70 3 0 3 0 0.01 +- 0.00 3 9

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12680 (3/3) SnoaL-like domain
PF08242 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_2765 106.36 +- 66.97 2 0 0 0 0.03 +- 0.06 2 6

PF03965 (2/2) Penicillinase repressor
PF01435 (2/2) Peptidase family M48
PF00403 (2/2) Heavy-metal-associated domain
PF12229 (1/2) Putative peptidoglycan binding domain
PF04294 (1/2) VanW like protein
PF00877 (1/2) NlpC/P60 family
precursor_jaccard_groups_7819 34.94 +- 12.33 2 0 0 0 0.07 +- 0.06 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF01872 (2/2) RibD C-terminal domain
precursor_jaccard_groups_1063 86.80 +- 20.88 3 0 0 0 0.05 +- 0.06 3 5

PF14534 (3/3) Domain of unknown function (DUF4440)
PF08002 (3/3) Protein of unknown function (DUF1697)
PF05922 (3/3) Peptidase inhibitor I9
PF00082 (3/3) Subtilase family
PF01323 (2/3) DSBA-like thioredoxin domain
precursor_jaccard_groups_7953 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain
precursor_jaccard_groups_40887 195.60 +- 94.65 2 0 2 0 0.02 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_34827 96.37 +- 5.37 2 0 0 0 0.03 +- 0.04 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_36680 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase
precursor_jaccard_groups_10178 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_10170 153.06 +- 34.46 4 0 4 0 0.06 +- 0.13 4 25

TIGR01762 (4/4) chlorinating enzyme
TIGR01733 (4/4) amino acid adenylation domain
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01444 (4/4) methyltransferase, FkbM family
TIGR00843 (4/4) benzoate transporter
PF16990 (4/4) Carbohydrate binding module (family 35)
PF13560 (4/4) Helix-turn-helix domain
PF13535 (4/4) ATP-grasp domain
PF13454 (4/4) FAD-NAD(P)-binding
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07691 (4/4) PA14 domain
PF06439 (4/4) Domain of Unknown Function (DUF1080)
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/4) Methyltransferase FkbM domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF03594 (4/4) Benzoate membrane transport protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_10172 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_38688 1632.40 +- 187.60 2 0 2 2 0.01 +- 0.00 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3368 87.16 +- 4.60 2 0 2 2 0.09 +- 0.18 2 12

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01292 (2/2) Prokaryotic cytochrome b561
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00188 (2/2) Cysteine-rich secretory protein family
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4194 48.47 +- 11.07 7 0 0 0 0.07 +- 0.10 7 5

PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (7/7) [2Fe-2S] binding domain
PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase
precursor_jaccard_groups_40812 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_12889 179.53 +- 21.38 2 0 2 0 0.08 +- 0.15 2 12

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_16101 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_jaccard_groups_2230 61.10 +- 12.21 3 0 1 0 0.05 +- 0.02 3 3

PF01292 (3/3) Prokaryotic cytochrome b561
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF07519 (2/3) Tannase and feruloyl esterase
precursor_jaccard_groups_1111 544.45 +- 297.46 29 0 0 0 0.02 +- 0.02 29 7

PF17914 (29/29) HopA1 effector protein family
PF05193 (29/29) Peptidase M16 inactive domain
PF02441 (29/29) Flavoprotein
PF00675 (29/29) Insulinase (Peptidase family M16)
PF13649 (28/29) Methyltransferase domain
PF00296 (24/29) Luciferase-like monooxygenase
PF00005 (22/29) ABC transporter
precursor_jaccard_groups_19369 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain
precursor_jaccard_groups_4810 2158.41 +- 761.00 8 0 1 0 0.01 +- 0.01 8 12

PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF05193 (8/8) Peptidase M16 inactive domain
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (8/8) Insulinase (Peptidase family M16)
PF00005 (8/8) ABC transporter
PF17874 (7/8) MalT-like TPR region
precursor_jaccard_groups_44133 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_33095 69.96 +- 24.43 2 0 0 2 0.05 +- 0.09 2 11

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_29992 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_3064 117.96 +- 49.34 4 0 0 0 0.03 +- 0.02 4 6

PF14759 (4/4) Reductase C-terminal
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF14016 (3/4) Protein of unknown function (DUF4232)
PF13370 (3/4) 4Fe-4S single cluster domain of Ferredoxin I
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_15901 365.31 +- 284.69 2 0 0 0 0.03 +- 0.05 2 3

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase
precursor_jaccard_groups_26167 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_340 1775.87 +- 1261.12 4 0 3 4 0.04 +- 0.14 4 8

PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein
precursor_jaccard_groups_343 285.64 +- 129.72 9 0 9 0 0.07 +- 0.14 9 16

TIGR03945 (9/9) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (9/9) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (9/9) amino acid adenylation domain
TIGR01720 (9/9) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (9/9) daunorubicin resistance ABC transporter, ATP-binding protein
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF03621 (9/9) MbtH-like protein
PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family
PF01061 (9/9) ABC-2 type transporter
PF00975 (9/9) Thioesterase domain
PF00668 (9/9) Condensation domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00291 (9/9) Pyridoxal-phosphate dependent enzyme
PF00005 (9/9) ABC transporter
PF13732 (7/9) Domain of unknown function (DUF4162)
precursor_jaccard_groups_20740 445.71 +- 74.29 2 0 2 0 0.01 +- 0.00 2 8

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_jaccard_groups_9015 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain
precursor_jaccard_groups_7544 187.56 +- 79.93 4 0 0 0 0.03 +- 0.04 4 5

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_21 40.24 +- 11.75 3 0 0 0 0.08 +- 0.17 3 3

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C
precursor_jaccard_groups_2928 239.85 +- 35.57 9 0 0 0 0.01 +- 0.00 9 3

PF13545 (9/9) Crp-like helix-turn-helix domain
PF07228 (9/9) Stage II sporulation protein E (SpoIIE)
PF00027 (9/9) Cyclic nucleotide-binding domain
precursor_jaccard_groups_29694 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_35370 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_7068 800.06 +- 256.65 6 0 5 0 0.01 +- 0.01 6 11

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_jaccard_groups_16192 325.00 +- 239.00 3 0 0 0 0.03 +- 0.08 3 3

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family
precursor_jaccard_groups_240 27.25 +- 2.74 9 0 3 0 0.07 +- 0.09 9 6

PF13244 (9/9) Domain of unknown function (DUF4040)
PF12840 (9/9) Helix-turn-helix domain
PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (9/9) Proton-conducting membrane transporter
precursor_jaccard_groups_9715 148.40 +- 67.91 5 0 0 0 0.02 +- 0.02 5 3

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_480 423.60 +- 111.96 20 0 4 0 0.05 +- 0.16 20 14

TIGR01850 (20/20) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (20/20) RimK-like ATP-grasp domain
PF02779 (20/20) Transketolase, pyrimidine binding domain
PF01118 (20/20) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (20/20) Transketolase, thiamine diphosphate binding domain
TIGR01902 (19/20) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (19/20) Peptidase family M20/M25/M40
PF01041 (19/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (19/20) Amino acid kinase family
TIGR00768 (16/20) alpha-L-glutamate ligase, RimK family
PF18603 (15/20) L-amino acid ligase C-terminal domain 2
PF18130 (15/20) ATP-grasp N-terminal domain
PF13535 (15/20) ATP-grasp domain
PF07690 (15/20) Major Facilitator Superfamily
precursor_jaccard_groups_13410 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_28573 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_15301 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_2331 229.23 +- 30.77 2 0 1 0 0.01 +- 0.01 2 7

PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00535 (2/2) Glycosyl transferase family 2
PF00005 (2/2) ABC transporter
PF13592 (1/2) Winged helix-turn helix
PF13384 (1/2) Homeodomain-like domain
PF13358 (1/2) DDE superfamily endonuclease
precursor_jaccard_groups_9155 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_41971 390.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_45631 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain
precursor_jaccard_groups_1529 4393.65 +- 2025.62 13 0 13 13 0.02 +- 0.07 13 8

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (13/13) Nitroreductase family
PF00005 (13/13) ABC transporter
PF05402 (10/13) Coenzyme PQQ synthesis protein D (PqqD)
PF12698 (7/13) ABC-2 family transporter protein
precursor_jaccard_groups_11329 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_38131 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_jaccard_groups_22415 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_jaccard_groups_8277 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_29303 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_45654 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28
precursor_jaccard_groups_4962 94.90 +- 28.28 4 0 0 0 0.04 +- 0.02 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family
precursor_jaccard_groups_3243 280.13 +- 235.87 2 0 0 2 0.05 +- 0.16 2 7

PF14518 (2/2) Iron-containing redox enzyme
PF12704 (2/2) MacB-like periplasmic core domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_14805 27.10 +- 6.92 3 0 0 0 0.08 +- 0.07 3 3

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_3576 122.11 +- 96.49 3 0 0 0 0.03 +- 0.04 3 5

TIGR01840 (3/3) esterase, PHB depolymerase family
TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (3/3) Protein of unknown function (DUF4232)
PF10503 (3/3) Esterase PHB depolymerase
PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_jaccard_groups_7966 864.29 +- 155.78 3 0 3 3 0.01 +- 0.02 3 9

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40595 209.46 +- 92.46 2 0 0 0 0.08 +- 0.08 2 11

TIGR01234 (2/2) ribulokinase
PF18029 (2/2) Glyoxalase-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_10347 447.82 +- 139.46 3 0 1 0 0.06 +- 0.21 3 11

PF17914 (3/3) HopA1 effector protein family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02441 (3/3) Flavoprotein
PF01636 (3/3) Phosphotransferase enzyme family
PF00326 (3/3) Prolyl oligopeptidase family
PF00296 (3/3) Luciferase-like monooxygenase
PF07730 (2/3) Histidine kinase
PF01061 (2/3) ABC-2 type transporter
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
PF00005 (2/3) ABC transporter
precursor_jaccard_groups_44899 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_2207 839.58 +- 460.42 4 2 2 4 0.02 +- 0.02 2 13

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
TIGR03731 (4/4) lantibiotic, gallidermin/nisin family
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (4/4) Lanthionine synthetase C-like protein
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF01061 (4/4) ABC-2 type transporter
PF00005 (4/4) ABC transporter
PF02052 (3/4) Gallidermin
TIGR02937 (2/4) RNA polymerase sigma factor, sigma-70 family
PF10709 (2/4) Protein of unknown function (DUF2511)
PF08281 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04072 (2/4) Leucine carboxyl methyltransferase
precursor_jaccard_groups_10572 1767.52 +- 216.09 3 0 1 3 0.01 +- 0.02 3 10

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family
precursor_jaccard_groups_8284 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin
precursor_jaccard_groups_18924 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain
precursor_jaccard_groups_5444 780.00 +- 260.00 6 0 0 6 0.01 +- 0.00 6 4

PF07690 (6/6) Major Facilitator Superfamily
PF04055 (6/6) Radical SAM superfamily
PF02441 (6/6) Flavoprotein
PF02310 (3/6) B12 binding domain
precursor_jaccard_groups_5448 206.28 +- 77.96 4 0 0 0 0.09 +- 0.09 4 17

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (4/4) Alpha galactosidase A
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
precursor_jaccard_groups_5722 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_570 247.62 +- 143.54 6 0 6 6 0.02 +- 0.03 6 4

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (5/6) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_37299 1068.75 +- 101.25 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_30800 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_4143 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_4145 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_29710 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_30662 582.00 +- 192.00 2 0 0 0 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_26287 105.74 +- 24.26 2 0 0 0 0.03 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_44459 344.00 +- 0.00 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_888 622.49 +- 466.04 22 0 22 0 0.07 +- 0.11 22 27

TIGR01733 (22/22) amino acid adenylation domain
TIGR01525 (22/22) heavy metal translocating P-type ATPase
PF13193 (22/22) AMP-binding enzyme C-terminal domain
PF10862 (22/22) FcoT-like thioesterase domain
PF08545 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (22/22) Male sterility protein
PF07690 (22/22) Major Facilitator Superfamily
PF05118 (22/22) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (22/22) Copper chaperone PCu(A)C
PF02668 (22/22) Taurine catabolism dioxygenase TauD, TfdA family
PF00702 (22/22) haloacid dehalogenase-like hydrolase
PF00668 (22/22) Condensation domain
PF00550 (22/22) Phosphopantetheine attachment site
PF00501 (22/22) AMP-binding enzyme
PF00403 (22/22) Heavy-metal-associated domain
PF00122 (22/22) E1-E2 ATPase
TIGR01746 (21/22) thioester reductase domain
TIGR00747 (21/22) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01497 (20/22) Periplasmic binding protein
PF01032 (20/22) FecCD transport family
PF00005 (20/22) ABC transporter
PF01965 (19/22) DJ-1/PfpI family
TIGR02937 (11/22) RNA polymerase sigma factor, sigma-70 family
PF08281 (11/22) Sigma-70, region 4
PF04542 (11/22) Sigma-70 region 2
PF03929 (11/22) PepSY-associated TM region
precursor_jaccard_groups_20631 516.00 +- 0.00 2 0 2 2 0.01 +- 0.00 2 7

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7757 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein
precursor_jaccard_groups_31899 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_7758 137.60 +- 68.80 2 0 0 0 0.06 +- 0.05 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_28707 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_477 128.69 +- 4.34 2 0 0 0 0.09 +- 0.07 2 14

PF14310 (2/2) Fibronectin type III-like domain
PF13802 (2/2) Galactose mutarotase-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07690 (1/2) Major Facilitator Superfamily
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_6694 806.75 +- 193.00 2 0 1 2 0.05 +- 0.17 2 26

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13581 (2/2) Histidine kinase-like ATPase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04672 (2/2) S-adenosyl methyltransferase
PF03457 (2/2) Helicase associated domain
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01590 (2/2) GAF domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13649 (1/2) Methyltransferase domain
PF08241 (1/2) Methyltransferase domain
PF00872 (1/2) Transposase, Mutator family
precursor_jaccard_groups_37668 328.15 +- 104.38 2 0 2 0 0.07 +- 0.16 2 15

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
precursor_jaccard_groups_22685 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase
precursor_jaccard_groups_37661 133.61 +- 63.96 2 0 2 0 0.09 +- 0.20 2 22

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16864 (2/2) Dimerisation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF04389 (2/2) Peptidase family M28
PF03621 (2/2) MbtH-like protein
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13847 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_3570 414.92 +- 442.96 5 0 0 0 0.06 +- 0.12 5 7

PF13407 (5/5) Periplasmic binding protein domain
PF13377 (5/5) Periplasmic binding protein-like domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00005 (5/5) ABC transporter
PF05025 (4/5) RbsD / FucU transport protein family
precursor_jaccard_groups_208 41.61 +- 0.00 2 0 2 0 0.10 +- 0.09 2 4

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (2/2) Major Facilitator Superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_21036 453.70 +- 99.16 2 0 0 0 0.03 +- 0.02 2 7

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6573 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II
precursor_jaccard_groups_1587 52.74 +- 14.93 6 0 0 0 0.06 +- 0.05 6 5

PF05331 (6/6) Protein of unknown function (DUF742)
PF04149 (6/6) Domain of unknown function (DUF397)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_44422 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III
precursor_jaccard_groups_41940 347.93 +- 153.74 2 0 2 2 0.05 +- 0.08 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_37196 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 3

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_102 500.84 +- 250.71 5 0 5 5 0.02 +- 0.05 5 11

TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM
PF13575 (5/5) Domain of unknown function (DUF4135)
PF13191 (5/5) AAA ATPase domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF00931 (5/5) NB-ARC domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13185 (4/5) GAF domain
PF08448 (4/5) PAS fold
PF07228 (4/5) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_37762 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_1299 56.37 +- 16.27 3 0 0 0 0.08 +- 0.07 3 4

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (3/3) Major Facilitator Superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_22033 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III
precursor_jaccard_groups_27906 149.12 +- 39.59 2 0 0 0 0.06 +- 0.02 2 7

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_44055 1163.94 +- 693.66 2 0 0 0 0.02 +- 0.01 2 18

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_43169 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_1997 38.95 +- 9.95 7 0 0 0 0.06 +- 0.09 7 5

PF17866 (7/7) AAA lid domain
PF13229 (7/7) Right handed beta helix region
PF00652 (7/7) Ricin-type beta-trefoil lectin domain
PF00082 (7/7) Subtilase family
PF00004 (7/7) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_4897 221.77 +- 79.53 9 0 0 0 0.05 +- 0.04 9 10

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_17197 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_25486 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_41790 133.48 +- 31.64 2 0 0 0 0.04 +- 0.04 2 6

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_8066 858.49 +- 193.39 4 0 4 4 0.01 +- 0.00 4 11

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_8416 174.02 +- 47.17 5 0 0 0 0.07 +- 0.10 5 7

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF12680 (5/5) SnoaL-like domain
PF07045 (5/5) Domain of unknown function (DUF1330)
PF01738 (5/5) Dienelactone hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter
precursor_jaccard_groups_21453 186.14 +- 8.86 2 0 0 0 0.03 +- 0.04 2 6

PF13564 (2/2) DoxX-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (2/2) NADPH-dependent FMN reductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF18616 (1/2) CDI immunity proteins
precursor_jaccard_groups_43205 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3309 637.59 +- 4.54 2 0 0 0 0.03 +- 0.02 2 14

TIGR00928 (2/2) adenylosuccinate lyase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13460 (2/2) NAD(P)H-binding
PF12800 (2/2) 4Fe-4S binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_43369 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_11383 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain
precursor_jaccard_groups_26078 627.35 +- 64.02 2 0 0 2 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
precursor_jaccard_groups_9943 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_29968 274.58 +- 189.71 2 0 2 0 0.03 +- 0.05 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_5577 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_jaccard_groups_10911 592.86 +- 404.30 3 0 0 0 0.05 +- 0.08 3 7

PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF01551 (3/3) Peptidase family M23
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF12679 (2/3) ABC-2 family transporter protein
precursor_jaccard_groups_35210 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_18487 358.75 +- 32.16 2 0 0 0 0.01 +- 0.01 2 18

TIGR01558 (2/2) putative phage terminase, small subunit, P27 family
TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/2) Phage-related minor tail protein
PF05119 (2/2) Phage terminase, small subunit
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04586 (2/2) Caudovirus prohead serine protease
PF04542 (2/2) Sigma-70 region 2
PF03354 (2/2) Phage Terminase
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (2/2) Collagen triple helix repeat (20 copies)
PF01381 (2/2) Helix-turn-helix
PF00271 (2/2) Helicase conserved C-terminal domain
precursor_jaccard_groups_43014 1363.59 +- 571.41 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7559 320.07 +- 19.07 2 0 2 0 0.05 +- 0.02 2 18

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (2/2) Amidohydrolase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (2/2) Coenzyme A transferase
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF01965 (1/2) DJ-1/PfpI family
precursor_jaccard_groups_30 272.98 +- 0.99 3 0 3 0 0.09 +- 0.18 3 11

TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF05013 (3/3) N-formylglutamate amidohydrolase
PF03412 (3/3) Peptidase C39 family
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF00664 (3/3) ABC transporter transmembrane region
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00005 (3/3) ABC transporter
PF13437 (2/3) HlyD family secretion protein
precursor_jaccard_groups_36 326.29 +- 70.74 5 0 0 0 0.07 +- 0.20 5 16

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF00691 (5/5) OmpA family
PF00482 (5/5) Type II secretion system (T2SS), protein F
TIGR03177 (4/5) Flp pilus assembly protein CpaB
PF16976 (4/5) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/5) AAA domain
PF07811 (4/5) TadE-like protein
PF07730 (4/5) Histidine kinase
PF00437 (4/5) Type II/IV secretion system protein
PF00196 (4/5) Bacterial regulatory proteins, luxR family
PF00072 (4/5) Response regulator receiver domain
PF15648 (3/5) Restriction endonuclease fold toxin 5
PF13231 (3/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
PF00496 (3/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/5) ABC transporter
precursor_jaccard_groups_531 366.81 +- 92.54 7 0 7 7 0.07 +- 0.08 7 12

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF13191 (7/7) AAA ATPase domain
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF03704 (7/7) Bacterial transcriptional activator domain
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (7/7) ABC-2 type transporter
PF00881 (7/7) Nitroreductase family
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00005 (7/7) ABC transporter
precursor_jaccard_groups_26233 117.00 +- 13.00 2 0 2 0 0.02 +- 0.01 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_5776 795.64 +- 536.08 8 0 8 8 0.03 +- 0.08 8 12

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_jaccard_groups_24455 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_11745 51.32 +- 24.99 3 0 0 0 0.05 +- 0.06 3 7

PF13424 (3/3) Tetratricopeptide repeat
PF07719 (3/3) Tetratricopeptide repeat
PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03413 (3/3) Peptidase propeptide and YPEB domain
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00348 (3/3) Polyprenyl synthetase
precursor_jaccard_groups_7987 383.81 +- 168.05 5 0 0 5 0.01 +- 0.03 5 7

TIGR00702 (5/5) YcaO-type kinase domain
PF18029 (5/5) Glyoxalase-like domain
PF13489 (5/5) Methyltransferase domain
PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (5/5) TfuA-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_jaccard_groups_24517 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region
precursor_jaccard_groups_10967 68.37 +- 29.84 3 0 0 0 0.07 +- 0.06 3 8

TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain
PF13399 (3/3) LytR cell envelope-related transcriptional attenuator
PF07859 (3/3) alpha/beta hydrolase fold
PF03816 (3/3) Cell envelope-related transcriptional attenuator domain
PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00459 (3/3) Inositol monophosphatase family
precursor_jaccard_groups_1313 427.40 +- 123.00 2 0 2 0 0.03 +- 0.03 2 6

TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_4352 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_17640 977.21 +- 452.79 2 0 2 2 0.01 +- 0.02 2 25

TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (2/2) mycofactocin precursor
TIGR03967 (2/2) putative mycofactocin binding protein MftB
TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (2/2) mycofactocin system glycosyltransferase
TIGR03964 (2/2) mycofactocin system creatininase family protein
TIGR03962 (2/2) mycofactocin radical SAM maturase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF08242 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF03129 (2/2) Anticodon binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF01070 (2/2) FMN-dependent dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00535 (2/2) Glycosyl transferase family 2
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_26806 227.25 +- 162.75 2 0 0 0 0.03 +- 0.05 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_30307 237.03 +- 98.37 2 0 0 0 0.02 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_6905 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family
precursor_jaccard_groups_20179 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_jaccard_groups_4527 119.08 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_14333 125.56 +- 76.73 4 0 0 0 0.02 +- 0.01 4 4

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain
precursor_jaccard_groups_710 1621.00 +- 1136.16 31 0 7 0 0.02 +- 0.06 31 9

PF17914 (31/31) HopA1 effector protein family
PF00664 (31/31) ABC transporter transmembrane region
PF00296 (31/31) Luciferase-like monooxygenase
PF00005 (31/31) ABC transporter
PF02441 (30/31) Flavoprotein
PF00675 (30/31) Insulinase (Peptidase family M16)
PF05193 (26/31) Peptidase M16 inactive domain
PF00891 (26/31) O-methyltransferase domain
PF01636 (25/31) Phosphotransferase enzyme family
precursor_jaccard_groups_1823 675.94 +- 720.50 12 0 12 1 0.03 +- 0.12 12 14

TIGR01850 (12/12) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (12/12) alpha-L-glutamate ligase, RimK family
PF13193 (12/12) AMP-binding enzyme C-terminal domain
PF08443 (12/12) RimK-like ATP-grasp domain
PF02780 (12/12) Transketolase, C-terminal domain
PF02779 (12/12) Transketolase, pyrimidine binding domain
PF02771 (12/12) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (12/12) Acyl-CoA dehydrogenase, middle domain
PF01118 (12/12) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (12/12) AMP-binding enzyme
PF00456 (12/12) Transketolase, thiamine diphosphate binding domain
PF00441 (12/12) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (9/12) LysR substrate binding domain
PF00126 (9/12) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_8841 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_43944 69.46 +- 4.96 2 0 0 0 0.04 +- 0.04 2 8

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12802 (1/2) MarR family
precursor_jaccard_groups_2843 4220.18 +- 876.74 7 4 3 7 0.01 +- 0.01 3 13

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/7) Nitroreductase family
PF00440 (6/7) Bacterial regulatory proteins, tetR family
PF00067 (6/7) Cytochrome P450
TIGR01891 (5/7) amidohydrolase
PF01546 (5/7) Peptidase family M20/M25/M40
PF00005 (5/7) ABC transporter
PF04738 (4/7) Lantibiotic dehydratase, N terminus
PF01061 (4/7) ABC-2 type transporter
precursor_jaccard_groups_14422 43.41 +- 0.41 2 0 2 0 0.07 +- 0.09 2 5

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_4553 235.19 +- 41.40 6 0 1 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (6/6) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_660 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like
precursor_jaccard_groups_6440 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_651 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_4416 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_9210 622.29 +- 125.90 3 0 3 0 0.01 +- 0.02 3 9

TIGR01250 (3/3) proline-specific peptidase
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (3/3) B12 binding domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_9269 43.48 +- 8.68 3 0 0 0 0.07 +- 0.05 3 9

PF13478 (3/3) XdhC Rossmann domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_28703 1580.73 +- 635.73 2 0 2 0 0.02 +- 0.04 2 14

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_13407 1191.19 +- 1181.25 4 1 1 4 0.05 +- 0.18 3 22

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/4) Methyltransferase domain
PF07993 (4/4) Male sterility protein
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF03176 (4/4) MMPL family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/4) MOSC domain
PF01575 (3/4) MaoC like domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF05193 (2/4) Peptidase M16 inactive domain
PF03476 (2/4) MOSC N-terminal beta barrel domain
PF00106 (2/4) short chain dehydrogenase
precursor_jaccard_groups_826 120.00 +- 0.00 2 0 0 0 0.10 +- 0.25 2 12

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold
precursor_jaccard_groups_981 222.67 +- 78.34 11 0 0 0 0.03 +- 0.02 11 10

TIGR03930 (11/11) WXG100 family type VII secretion target
TIGR03920 (11/11) type VII secretion integral membrane protein EccD
TIGR03919 (11/11) type VII secretion protein EccB
PF15644 (11/11) Papain fold toxin 1, glutamine deamidase
PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD
PF07179 (11/11) SseB protein N-terminal domain
PF06013 (11/11) Proteins of 100 residues with WXG
PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B
PF02575 (11/11) YbaB/EbfC DNA-binding family
PF00652 (11/11) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_1387 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_jaccard_groups_31238 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_16546 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme
precursor_jaccard_groups_6978 47.10 +- 5.79 3 0 0 0 0.06 +- 0.05 3 5

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (3/3) SCP-2 sterol transfer family
precursor_jaccard_groups_43400 971.25 +- 3.75 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35828 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_34206 306.43 +- 83.57 2 0 2 0 0.01 +- 0.00 2 7

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_28096 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_11184 144.69 +- 113.31 2 0 0 0 0.04 +- 0.06 2 5

PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF13560 (2/2) Helix-turn-helix domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF04149 (2/2) Domain of unknown function (DUF397)
precursor_jaccard_groups_1003 472.48 +- 223.76 3 0 3 0 0.05 +- 0.13 3 15

TIGR01733 (3/3) amino acid adenylation domain
PF13560 (3/3) Helix-turn-helix domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (3/3) B12 binding domain
PF01645 (3/3) Conserved region in glutamate synthase
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00152 (3/3) tRNA synthetases class II (D, K and N)
PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily
precursor_jaccard_groups_20536 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_7977 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_12000 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family
precursor_jaccard_groups_3188 358.32 +- 74.43 10 0 6 0 0.06 +- 0.03 10 18

PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF01144 (10/10) Coenzyme A transferase
PF00378 (10/10) Enoyl-CoA hydratase/isomerase
PF00196 (10/10) Bacterial regulatory proteins, luxR family
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00106 (10/10) short chain dehydrogenase
PF00005 (10/10) ABC transporter
TIGR00976 (9/10) hydrolase CocE/NonD family protein
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF12679 (9/10) ABC-2 family transporter protein
PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/10) AMP-binding enzyme
PF04909 (8/10) Amidohydrolase
PF12697 (7/10) Alpha/beta hydrolase family
precursor_jaccard_groups_32135 372.32 +- 128.18 2 0 0 0 0.03 +- 0.03 2 9

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_34449 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_1645 333.77 +- 152.43 6 0 1 0 0.02 +- 0.03 6 6

PF07291 (6/6) Methylamine utilisation protein MauE
PF00717 (6/6) Peptidase S24-like
PF00578 (6/6) AhpC/TSA family
PF00005 (6/6) ABC transporter
PF12833 (4/6) Helix-turn-helix domain
PF10502 (3/6) Signal peptidase, peptidase S26
precursor_jaccard_groups_8196 273.59 +- 115.10 6 0 0 0 0.03 +- 0.01 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase
precursor_jaccard_groups_3616 196.34 +- 50.80 5 0 0 0 0.08 +- 0.07 5 10

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00005 (5/5) ABC transporter
PF00296 (3/5) Luciferase-like monooxygenase
precursor_jaccard_groups_14902 253.73 +- 93.57 2 0 0 0 0.05 +- 0.06 2 11

PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_19995 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_19998 24.99 +- 2.38 2 0 0 0 0.08 +- 0.07 2 3

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00457 (2/2) Glycosyl hydrolases family 11
PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_30270 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_jaccard_groups_14043 332.84 +- 267.53 3 0 0 0 0.06 +- 0.12 3 18

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
precursor_jaccard_groups_26753 21.30 +- 0.66 2 0 0 0 0.09 +- 0.13 2 5

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_34537 168.50 +- 39.50 2 0 0 0 0.03 +- 0.02 2 7

PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_33923 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_26615 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family
precursor_jaccard_groups_42614 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain
precursor_jaccard_groups_42116 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_37472 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_42252 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA
precursor_jaccard_groups_16345 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_26100 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_9042 4562.99 +- 1627.42 5 0 2 0 0.01 +- 0.03 5 10

PF17914 (5/5) HopA1 effector protein family
PF13649 (5/5) Methyltransferase domain
PF05193 (5/5) Peptidase M16 inactive domain
PF02441 (5/5) Flavoprotein
PF00675 (5/5) Insulinase (Peptidase family M16)
PF00664 (5/5) ABC transporter transmembrane region
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
PF01527 (4/5) Transposase
PF01061 (4/5) ABC-2 type transporter
precursor_jaccard_groups_42508 61.28 +- 3.22 2 0 0 0 0.05 +- 0.03 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_25436 195.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_2566 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_jaccard_groups_22912 205.89 +- 16.36 2 0 0 0 0.06 +- 0.11 2 15

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (2/2) Domain of unknown function (DUF4380)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_29429 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase
precursor_jaccard_groups_11638 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain
precursor_jaccard_groups_29587 38.91 +- 7.53 2 0 0 0 0.08 +- 0.05 2 4

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_30588 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_11636 167.66 +- 10.77 2 0 0 0 0.06 +- 0.03 2 9

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_215 32.76 +- 4.10 2 0 0 0 0.06 +- 0.03 2 2

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_3468 75.88 +- 0.00 2 0 0 2 0.07 +- 0.07 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_742 82.30 +- 46.49 40 0 38 40 0.05 +- 0.02 40 3

PF13471 (40/40) Transglutaminase-like superfamily
PF05402 (40/40) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (40/40) Asparagine synthase
precursor_jaccard_groups_41550 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase
precursor_jaccard_groups_32091 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_14462 144.98 +- 11.02 2 0 0 0 0.09 +- 0.06 2 16

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
precursor_jaccard_groups_1598 57.96 +- 12.04 2 0 0 2 0.05 +- 0.10 2 9

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily
precursor_jaccard_groups_41497 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_15368 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_9130 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_29102 175.06 +- 37.41 2 0 0 0 0.03 +- 0.04 2 9

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_13679 34.39 +- 12.89 2 0 2 0 0.09 +- 0.08 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator
precursor_jaccard_groups_28294 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_15412 138.46 +- 43.67 3 0 0 0 0.03 +- 0.02 3 9

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_3796 885.57 +- 176.07 4 0 1 0 0.01 +- 0.01 4 9

TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (4/4) Major Facilitator Superfamily
PF03737 (4/4) Aldolase/RraA
PF03466 (4/4) LysR substrate binding domain
PF01361 (4/4) Tautomerase enzyme
PF00994 (4/4) Probable molybdopterin binding domain
PF00682 (4/4) HMGL-like
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_2704 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix
precursor_jaccard_groups_8499 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_jaccard_groups_43471 151.58 +- 28.42 2 0 0 0 0.02 +- 0.02 2 3

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_27320 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_18062 291.05 +- 29.25 2 0 0 0 0.08 +- 0.18 2 21

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF12831 (2/2) FAD dependent oxidoreductase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (2/2) CoA-transferase family III
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01381 (2/2) Helix-turn-helix
PF01380 (2/2) SIS domain
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1609 46.64 +- 3.06 3 0 0 0 0.06 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain
precursor_jaccard_groups_870 104.64 +- 38.90 15 0 0 0 0.06 +- 0.07 15 9

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase
precursor_jaccard_groups_11307 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_4943 375.44 +- 131.77 2 0 2 0 0.09 +- 0.21 2 34

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF00857 (1/2) Isochorismatase family
precursor_jaccard_groups_23563 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7393 47.52 +- 9.22 3 0 0 0 0.04 +- 0.05 3 3

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_1131 516.00 +- 129.00 2 0 2 2 0.01 +- 0.00 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (1/2) ABC transporter
precursor_jaccard_groups_26322 7843.20 +- 6508.80 2 0 2 2 0.05 +- 0.15 2 21

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_jaccard_groups_37336 23.45 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_41413 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_19421 322.50 +- 0.00 2 0 2 0 0.02 +- 0.00 2 6

PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1730 27.06 +- 5.19 2 0 0 0 0.09 +- 0.10 2 7

PF13516 (2/2) Leucine Rich repeat
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF14435 (1/2) SUKH-4 immunity protein
PF12796 (1/2) Ankyrin repeats (3 copies)
PF01738 (1/2) Dienelactone hydrolase family
precursor_jaccard_groups_883 91.17 +- 58.33 18 0 0 0 0.03 +- 0.02 18 3

PF12833 (18/18) Helix-turn-helix domain
PF02311 (18/18) AraC-like ligand binding domain
PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_33885 132.91 +- 39.09 2 0 0 0 0.05 +- 0.09 2 7

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_39349 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_3728 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_jaccard_groups_2220 57.64 +- 2.36 2 0 0 0 0.07 +- 0.09 2 4

PF04203 (2/2) Sortase domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_21166 1225.09 +- 465.17 3 0 3 3 0.01 +- 0.01 3 9

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR04353 (2/3) PqqD family protein, HPr-rel-A system
PF13646 (2/3) HEAT repeats
PF13411 (2/3) MerR HTH family regulatory protein
precursor_jaccard_groups_23668 230.67 +- 116.00 2 0 0 0 0.02 +- 0.03 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_253 355.50 +- 160.50 4 2 2 4 0.03 +- 0.03 2 5

PF05147 (4/4) Lanthionine synthetase C-like protein
PF01061 (4/4) ABC-2 type transporter
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein
precursor_jaccard_groups_91 243.84 +- 133.73 4 0 1 4 0.07 +- 0.08 4 8

TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01497 (2/4) Periplasmic binding protein
PF01032 (2/4) FecCD transport family
precursor_jaccard_groups_9372 400.13 +- 221.16 3 0 1 0 0.05 +- 0.17 3 26

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain
precursor_jaccard_groups_26664 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_21200 398.33 +- 178.68 3 0 0 0 0.02 +- 0.01 3 8

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_32436 476.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 3

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2686 203.13 +- 221.37 6 0 4 0 0.05 +- 0.10 6 6

PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (6/6) BFD-like [2Fe-2S] binding domain
PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (6/6) FAD dependent oxidoreductase
PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (4/6) NUDIX domain
precursor_jaccard_groups_29077 183.91 +- 13.29 2 0 0 0 0.08 +- 0.06 2 18

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_jaccard_groups_24503 73.19 +- 11.76 2 0 2 0 0.08 +- 0.08 2 14

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13560 (2/2) Helix-turn-helix domain
PF13478 (2/2) XdhC Rossmann domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00756 (2/2) Putative esterase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_17655 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4347 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase
precursor_jaccard_groups_3429 1363.95 +- 1630.95 4 0 4 4 0.04 +- 0.08 4 14

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF03704 (4/4) Bacterial transcriptional activator domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (4/4) ABC-2 type transporter
PF00881 (4/4) Nitroreductase family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00005 (4/4) ABC transporter
TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor
TIGR01891 (3/4) amidohydrolase
PF01546 (3/4) Peptidase family M20/M25/M40
PF00296 (2/4) Luciferase-like monooxygenase
precursor_jaccard_groups_18235 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site
precursor_jaccard_groups_21063 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_jaccard_groups_792 680.47 +- 421.39 6 0 3 6 0.05 +- 0.09 6 22

TIGR04364 (6/6) methyltransferase, FxLD system
TIGR04363 (6/6) FxLD family lantipeptide
TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05331 (6/6) Protein of unknown function (DUF742)
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF01427 (6/6) D-ala-D-ala dipeptidase
PF01135 (6/6) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (6/6) NUDIX domain
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF00005 (6/6) ABC transporter
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain
PF01590 (5/6) GAF domain
PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain
PF02518 (4/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00723 (4/6) Glycosyl hydrolases family 15
PF13671 (3/6) AAA domain
PF13649 (3/6) Methyltransferase domain
precursor_jaccard_groups_18533 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_6734 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat
precursor_jaccard_groups_20649 91.36 +- 15.97 3 0 0 0 0.06 +- 0.11 3 8

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF00717 (3/3) Peptidase S24-like
PF00501 (3/3) AMP-binding enzyme
PF00092 (3/3) von Willebrand factor type A domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_7647 2698.22 +- 1333.42 6 0 6 6 0.01 +- 0.01 6 9

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13560 (6/6) Helix-turn-helix domain
PF04149 (6/6) Domain of unknown function (DUF397)
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/6) Nitroreductase family
PF00196 (5/6) Bacterial regulatory proteins, luxR family
TIGR03891 (3/6) thiopeptide-type bacteriocin biosynthesis domain
precursor_jaccard_groups_5516 128.12 +- 45.26 4 0 4 0 0.08 +- 0.18 4 20

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (4/4) Thioesterase domain
PF00877 (4/4) NlpC/P60 family
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12158 (2/4) Protein of unknown function (DUF3592)
PF01145 (2/4) SPFH domain / Band 7 family
precursor_jaccard_groups_28413 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_24164 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_670 203.30 +- 256.64 4 0 0 0 0.04 +- 0.05 4 2

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase
precursor_jaccard_groups_8262 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family
precursor_jaccard_groups_172 318.82 +- 276.51 5 0 2 0 0.05 +- 0.08 5 16

TIGR01525 (5/5) heavy metal translocating P-type ATPase
PF04314 (5/5) Copper chaperone PCu(A)C
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
TIGR00802 (4/5) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (4/5) GYF domain 2
PF13421 (4/5) SPFH domain-Band 7 family
PF08281 (4/5) Sigma-70, region 4
PF07690 (4/5) Major Facilitator Superfamily
PF04542 (4/5) Sigma-70 region 2
PF03824 (4/5) High-affinity nickel-transport protein
PF13738 (3/5) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (3/5) FMN-dependent dehydrogenase
PF00067 (3/5) Cytochrome P450
precursor_jaccard_groups_27768 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_10899 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase
precursor_jaccard_groups_836 687.94 +- 313.54 3 1 2 3 0.02 +- 0.02 2 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00069 (3/3) Protein kinase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00494 (2/3) Squalene/phytoene synthase
precursor_jaccard_groups_380 182.02 +- 102.07 14 0 14 13 0.04 +- 0.05 14 5

TIGR03975 (14/14) ribosomal peptide maturation radical SAM protein 1
PF07690 (14/14) Major Facilitator Superfamily
PF02310 (14/14) B12 binding domain
PF00326 (14/14) Prolyl oligopeptidase family
PF04055 (13/14) Radical SAM superfamily
precursor_jaccard_groups_6961 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_33409 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_27103 143.00 +- 117.00 2 0 0 0 0.04 +- 0.07 2 3

PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_43595 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)
precursor_jaccard_groups_12176 186.44 +- 101.19 3 0 0 0 0.02 +- 0.02 3 7

PF16353 (3/3) Domain of unknown function(DUF4981)
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (3/3) Glycosyl hydrolases family 2
precursor_jaccard_groups_40521 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_jaccard_groups_19576 215.00 +- 60.81 3 0 3 0 0.01 +- 0.01 3 3

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_44613 91.60 +- 0.33 2 0 2 0 0.10 +- 0.29 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_44970 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_3196 79.05 +- 17.93 5 0 0 0 0.08 +- 0.03 5 9

TIGR02133 (5/5) ribose 5-phosphate isomerase
PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (5/5) Major Facilitator Superfamily
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF02734 (5/5) DAK2 domain
PF02733 (5/5) Dak1 domain
PF02502 (5/5) Ribose/Galactose Isomerase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00121 (5/5) Triosephosphate isomerase
precursor_jaccard_groups_39304 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_11860 114.31 +- 18.14 2 0 0 0 0.08 +- 0.04 2 5

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_44856 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_38287 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6
precursor_jaccard_groups_8003 2401.56 +- 1135.16 3 0 0 0 0.02 +- 0.01 3 13

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (3/3) ATP-grasp domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01613 (3/3) Flavin reductase like domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00106 (3/3) short chain dehydrogenase
PF18130 (2/3) ATP-grasp N-terminal domain
precursor_jaccard_groups_34641 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_42264 130.00 +- 70.00 2 0 0 0 0.04 +- 0.03 2 6

PF12833 (2/2) Helix-turn-helix domain
PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/2) mttA/Hcf106 family
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_14078 150.50 +- 136.83 4 0 0 0 0.03 +- 0.02 4 3

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)
precursor_jaccard_groups_37594 109.51 +- 1.92 2 0 0 0 0.04 +- 0.03 2 6

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_5839 1561.23 +- 946.56 6 0 6 0 0.02 +- 0.07 6 12

PF13622 (6/6) Thioesterase-like superfamily
PF07690 (6/6) Major Facilitator Superfamily
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00487 (6/6) Fatty acid desaturase
PF00301 (6/6) Rubredoxin
PF00067 (6/6) Cytochrome P450
PF12679 (4/6) ABC-2 family transporter protein
PF12146 (4/6) Serine aminopeptidase, S33
PF00005 (4/6) ABC transporter
TIGR00711 (3/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF00392 (3/6) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_2272 359.93 +- 257.30 9 0 9 0 0.04 +- 0.07 9 10

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase
precursor_jaccard_groups_5207 964.27 +- 325.73 2 0 0 0 0.01 +- 0.02 2 12

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40 353.21 +- 291.79 2 0 2 0 0.03 +- 0.08 2 15

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
PF12680 (1/2) SnoaL-like domain
PF08242 (1/2) Methyltransferase domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2073 802.19 +- 237.81 5 3 2 5 0.01 +- 0.00 2 9

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (5/5) Nitroreductase family
TIGR03605 (3/5) SagB-type dehydrogenase domain
PF13191 (3/5) AAA ATPase domain
PF00196 (3/5) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_4767 234.57 +- 34.56 3 0 0 0 0.01 +- 0.00 3 4

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03713 (3/3) Domain of unknown function (DUF305)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
precursor_jaccard_groups_35789 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_16211 260.13 +- 5.78 2 0 0 0 0.02 +- 0.01 2 11

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00326 (2/2) riboflavin biosynthesis protein RibD
PF13641 (2/2) Glycosyltransferase like family 2
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (2/2) RibD C-terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_584 192.97 +- 127.67 14 0 14 14 0.05 +- 0.03 14 13

TIGR04451 (14/14) lantipeptide, SCO0268 family
TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF05147 (14/14) Lanthionine synthetase C-like protein
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF12802 (9/14) MarR family
PF12697 (9/14) Alpha/beta hydrolase family
PF02065 (9/14) Melibiase
PF01547 (9/14) Bacterial extracellular solute-binding protein
PF00528 (9/14) Binding-protein-dependent transport system inner membrane component
PF00480 (9/14) ROK family
PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_10702 49.71 +- 15.29 2 0 2 2 0.07 +- 0.08 2 6

PF14518 (2/2) Iron-containing redox enzyme
PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_946 505.07 +- 225.49 23 0 23 23 0.03 +- 0.05 23 6

PF05147 (23/23) Lanthionine synthetase C-like protein
PF04672 (23/23) S-adenosyl methyltransferase
PF00664 (23/23) ABC transporter transmembrane region
PF00326 (23/23) Prolyl oligopeptidase family
PF00069 (23/23) Protein kinase domain
PF00005 (23/23) ABC transporter
precursor_jaccard_groups_25249 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_42565 523.42 +- 54.35 2 0 2 2 0.05 +- 0.08 2 18

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13575 (2/2) Domain of unknown function (DUF4135)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00664 (2/2) ABC transporter transmembrane region
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07366 (1/2) SnoaL-like polyketide cyclase
precursor_jaccard_groups_18179 50.96 +- 24.18 3 0 0 0 0.05 +- 0.03 3 3

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_18473 332.14 +- 118.84 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family
precursor_jaccard_groups_7175 218.17 +- 57.06 5 0 5 5 0.05 +- 0.06 5 9

PF08386 (5/5) TAP-like protein
PF05532 (5/5) CsbD-like
PF05147 (5/5) Lanthionine synthetase C-like protein
PF00664 (5/5) ABC transporter transmembrane region
PF00561 (5/5) alpha/beta hydrolase fold
PF00069 (5/5) Protein kinase domain
PF00005 (5/5) ABC transporter
PF12697 (4/5) Alpha/beta hydrolase family
PF00117 (3/5) Glutamine amidotransferase class-I
precursor_jaccard_groups_18578 63.35 +- 11.31 3 0 0 0 0.05 +- 0.03 3 4

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_29183 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_2398 953.88 +- 214.88 4 0 0 4 0.01 +- 0.01 4 7

TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
precursor_jaccard_groups_32647 381.16 +- 102.59 2 0 0 0 0.02 +- 0.02 2 4

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
precursor_jaccard_groups_21054 324.25 +- 46.50 3 0 3 0 0.01 +- 0.00 3 7

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_1683 1303.55 +- 601.09 16 1 15 16 0.02 +- 0.01 15 8

TIGR03898 (16/16) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (16/16) type 2 lantibiotic biosynthesis protein LanM
PF13575 (16/16) Domain of unknown function (DUF4135)
PF05147 (16/16) Lanthionine synthetase C-like protein
PF03412 (16/16) Peptidase C39 family
PF00664 (16/16) ABC transporter transmembrane region
PF00005 (16/16) ABC transporter
PF12679 (14/16) ABC-2 family transporter protein
precursor_jaccard_groups_4506 299.00 +- 23.50 2 0 0 0 0.05 +- 0.09 2 12

TIGR01764 (2/2) DNA binding domain, excisionase family
PF13411 (2/2) MerR HTH family regulatory protein
PF13245 (2/2) AAA domain
PF12728 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF12679 (2/2) ABC-2 family transporter protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF01551 (2/2) Peptidase family M23
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_2899 191.56 +- 72.66 4 0 0 0 0.07 +- 0.11 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_jaccard_groups_45300 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_28463 24.72 +- 1.08 2 0 0 0 0.08 +- 0.08 2 4

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase
precursor_jaccard_groups_29296 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_10796 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_jaccard_groups_24990 139.98 +- 39.33 2 0 0 0 0.04 +- 0.04 2 6

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_41969 433.58 +- 275.92 2 0 0 0 0.04 +- 0.03 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_124 359.72 +- 141.51 6 0 0 0 0.02 +- 0.04 6 6

PF07739 (6/6) TipAS antibiotic-recognition domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF13411 (5/6) MerR HTH family regulatory protein
PF01551 (5/6) Peptidase family M23
precursor_jaccard_groups_27389 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase
precursor_jaccard_groups_22400 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family
precursor_jaccard_groups_12706 1070.36 +- 277.93 4 0 0 0 0.02 +- 0.01 4 9

PF17914 (4/4) HopA1 effector protein family
PF13649 (4/4) Methyltransferase domain
PF12698 (4/4) ABC-2 family transporter protein
PF02441 (4/4) Flavoprotein
PF01636 (4/4) Phosphotransferase enzyme family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF13732 (3/4) Domain of unknown function (DUF4162)
PF00196 (3/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_37144 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family
precursor_jaccard_groups_37140 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_jaccard_groups_848 137.11 +- 11.03 4 0 4 4 0.03 +- 0.04 4 3

PF13471 (4/4) Transglutaminase-like superfamily
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00733 (4/4) Asparagine synthase
precursor_jaccard_groups_4970 759.98 +- 690.09 3 0 3 3 0.06 +- 0.20 3 6

PF06114 (3/3) IrrE N-terminal-like domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter
precursor_jaccard_groups_34265 118.75 +- 11.25 2 0 0 0 0.08 +- 0.11 2 7

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10247 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_jaccard_groups_1631 34.67 +- 0.00 2 0 0 0 0.09 +- 0.12 2 5

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF11361 (2/2) Protein of unknown function (DUF3159)
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (2/2) Polysaccharide deacetylase
precursor_jaccard_groups_3153 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
Halogenase 1426.13 +- 1991.63 7 0 7 4 0.05 +- 0.18 7 10

PF04820 (7/7) Tryptophan halogenase
PF00664 (5/7) ABC transporter transmembrane region
PF00005 (5/7) ABC transporter
TIGR03897 (4/7) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/7) Lantibiotic alpha
PF13601 (4/7) Winged helix DNA-binding domain
PF13575 (4/7) Domain of unknown function (DUF4135)
PF05147 (4/7) Lanthionine synthetase C-like protein
PF03412 (4/7) Peptidase C39 family
PF00296 (4/7) Luciferase-like monooxygenase
Acyltransferases 414.85 +- 530.77 260 0 109 33 0.05 +- 0.09 260

No common domains found
Transferring Alkyl or Aryl Groups Other than Methyl Groups 697.53 +- 788.60 37 0 24 0 0.05 +- 0.14 37 1

PF00275 (19/37) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
Glycosyltransferases 546.19 +- 678.37 62 0 12 7 0.03 +- 0.09 62

No common domains found
Transferring Aldehyde or Ketonic Groups 564.73 +- 487.29 43 0 24 1 0.04 +- 0.14 43 10

PF00456 (39/43) Transketolase, thiamine diphosphate binding domain
PF02779 (37/43) Transketolase, pyrimidine binding domain
TIGR01850 (34/43) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (34/43) RimK-like ATP-grasp domain
PF01118 (34/43) Semialdehyde dehydrogenase, NAD binding domain
TIGR00768 (30/43) alpha-L-glutamate ligase, RimK family
TIGR01902 (23/43) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (23/43) Peptidase family M20/M25/M40
PF01041 (23/43) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (23/43) Amino acid kinase family
Transferring One-Carbon Groups 753.50 +- 851.88 162 0 66 46 0.03 +- 0.09 162

No common domains found
Transferring Phosphorus-Containing Groups 435.80 +- 1086.83 193 0 63 17 0.05 +- 0.13 193

No common domains found
Transferring Sulfur-Containing Groups 464.98 +- 305.80 18 0 10 2 0.05 +- 0.04 18 18

PF01144 (16/18) Coenzyme A transferase
PF00005 (15/18) ABC transporter
PF13193 (14/18) AMP-binding enzyme C-terminal domain
PF00501 (14/18) AMP-binding enzyme
PF00378 (14/18) Enoyl-CoA hydratase/isomerase
PF13561 (13/18) Enoyl-(Acyl carrier protein) reductase
PF08545 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (13/18) Beta-ketoacyl synthase, C-terminal domain
PF00196 (13/18) Bacterial regulatory proteins, luxR family
PF00109 (13/18) Beta-ketoacyl synthase, N-terminal domain
PF00106 (13/18) short chain dehydrogenase
TIGR00976 (12/18) hydrolase CocE/NonD family protein
PF08530 (12/18) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (12/18) X-Pro dipeptidyl-peptidase (S15 family)
PF04909 (11/18) Amidohydrolase
PF12679 (10/18) ABC-2 family transporter protein
PF12697 (9/18) Alpha/beta hydrolase family
Transferring Nitrogenous Groups 622.73 +- 650.75 97 0 43 20 0.04 +- 0.13 97 2

PF07690 (59/97) Major Facilitator Superfamily
PF00202 (59/97) Aminotransferase class-III
Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
Streptomyces hygroscopicus subsp. hygroscopicus 177.99 +- 112.62 5 0 0 0 0.05 +- 0.05 5 1

PF07690 (3/5) Major Facilitator Superfamily
Streptomyces rimosus subsp. rimosus 44.23 +- 0.00 1 0 1 1 0.07 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces lydicus 466.63 +- 589.37 3 0 0 0 0.03 +- 0.05 3 1

PF00067 (2/3) Cytochrome P450
Streptomyces virginiae 217.83 +- 233.93 3 0 1 0 0.04 +- 0.03 3

No common domains found
Streptomyces sp. NRRL S-384 116.85 +- 0.00 1 0 1 1 0.09 +- 0.21 1 10

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (1/1) Domain of unknown function (DUF4135)
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00067 (1/1) Cytochrome P450
PF00005 (1/1) ABC transporter
Streptomyces albidoflavus 107.50 +- 0.00 1 0 0 0 0.02 +- 0.02 1 4

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces sp. ms115 545.43 +- 410.74 3 0 1 1 0.02 +- 0.02 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. NRRL S-495 335.43 +- 221.84 3 0 0 0 0.03 +- 0.03 3 4

PF13377 (2/3) Periplasmic binding protein-like domain
PF02065 (2/3) Melibiase
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00356 (2/3) Bacterial regulatory proteins, lacI family
Streptomyces antibioticus 577.06 +- 772.10 5 0 1 0 0.04 +- 0.08 5

No common domains found
Streptomyces pactum 1419.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 18

PF16197 (1/1) Ketoacyl-synthetase C-terminal extension
PF14765 (1/1) Polyketide synthase dehydratase
PF13191 (1/1) AAA ATPase domain
PF08659 (1/1) KR domain
PF04820 (1/1) Tryptophan halogenase
PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (1/1) Bacterial transcriptional activator domain
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01613 (1/1) Flavin reductase like domain
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00698 (1/1) Acyl transferase domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces sp. st170 451.50 +- 0.00 1 0 1 1 0.02 +- 0.02 1 6

PF05147 (1/1) Lanthionine synthetase C-like protein
PF04672 (1/1) S-adenosyl methyltransferase
PF00664 (1/1) ABC transporter transmembrane region
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces albovinaceus 113.75 +- 0.00 1 0 0 0 0.03 +- 0.01 1 5

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
Streptomyces clavuligerus 418.54 +- 378.23 2 0 1 0 0.02 +- 0.05 2 21

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF18181 (1/2) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (1/2) Dimerisation domain
PF14015 (1/2) Protein of unknown function (DUF4231)
PF13692 (1/2) Glycosyl transferases group 1
PF13676 (1/2) TIR domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13292 (1/2) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (1/2) Maltose acetyltransferase
PF11941 (1/2) Domain of unknown function (DUF3459)
PF08386 (1/2) TAP-like protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF05729 (1/2) NACHT domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF02388 (1/2) FemAB family
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00202 (1/2) Aminotransferase class-III
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
Streptomyces lavendulae subsp. lavendulae 91.45 +- 44.83 4 0 1 1 0.05 +- 0.05 4

No common domains found
Streptomyces purpureus KA281 231.24 +- 173.22 4 0 0 1 0.04 +- 0.05 4

No common domains found
Streptomyces albidoflavus 21.50 +- 0.00 1 0 0 0 0.09 +- 0.05 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
[Kitasatospora] papulosa 451.50 +- 0.00 1 0 1 1 0.02 +- 0.00 1 7

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF03466 (1/1) LysR substrate binding domain
PF02310 (1/1) B12 binding domain
PF00733 (1/1) Asparagine synthase
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces sp. WAC 01438 1161.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 8

TIGR01187 (1/1) polyamine ABC transporter, ATP-binding protein
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13416 (1/1) Bacterial extracellular solute-binding protein
PF09339 (1/1) IclR helix-turn-helix domain
PF08402 (1/1) TOBE domain
PF04199 (1/1) Putative cyclase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter
Streptomyces sp. WM6378 493.22 +- 395.49 3 0 1 1 0.04 +- 0.06 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. B27 26.96 +- 0.00 1 0 0 0 0.07 +- 0.11 1 6

TIGR01525 (1/1) heavy metal translocating P-type ATPase
PF04314 (1/1) Copper chaperone PCu(A)C
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00069 (1/1) Protein kinase domain
Streptomyces sp. ICC4 355.13 +- 136.45 3 0 1 0 0.01 +- 0.01 3

No common domains found
Streptomyces hirsutus 709.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03296 (1/2) M6 family metalloprotease domain
PF14759 (1/2) Reductase C-terminal
PF13279 (1/2) Thioesterase-like superfamily
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (1/2) Flavin reductase like domain
PF00775 (1/2) Dioxygenase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00082 (1/2) Subtilase family
PF00067 (1/2) Cytochrome P450
Streptomyces sp. NTK 937 186.43 +- 36.43 2 0 0 1 0.02 +- 0.01 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF13649 (1/2) Methyltransferase domain
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF00884 (1/2) Sulfatase
Streptomyces sp. KPB2 702.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 9

TIGR00710 (1/1) drug resistance transporter, Bcr/CflA subfamily
PF07690 (1/1) Major Facilitator Superfamily
PF03737 (1/1) Aldolase/RraA
PF03466 (1/1) LysR substrate binding domain
PF01361 (1/1) Tautomerase enzyme
PF00994 (1/1) Probable molybdopterin binding domain
PF00682 (1/1) HMGL-like
PF00180 (1/1) Isocitrate/isopropylmalate dehydrogenase
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces sp. LaPpAH-108 147.43 +- 0.00 1 0 0 1 0.03 +- 0.01 1 3

PF07702 (1/1) UTRA domain
PF04055 (1/1) Radical SAM superfamily
PF00392 (1/1) Bacterial regulatory proteins, gntR family
Streptomyces sp. NRRL WC-3742 339.65 +- 407.90 7 0 1 1 0.03 +- 0.07 7

No common domains found
Streptomyces sp. MMG1533 127.32 +- 67.68 2 0 0 0 0.06 +- 0.12 2 23

TIGR00167 (1/2) ketose-bisphosphate aldolase
PF17042 (1/2) Nucleotide-binding C-terminal domain
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13407 (1/2) Periplasmic binding protein domain
PF13401 (1/2) AAA domain
PF13185 (1/2) GAF domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF09851 (1/2) Short C-terminal domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08447 (1/2) PAS fold
PF07729 (1/2) FCD domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF07005 (1/2) Sugar-binding N-terminal domain
PF04203 (1/2) Sortase domain
PF03631 (1/2) Virulence factor BrkB
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (1/2) GntP family permease
PF01614 (1/2) Bacterial transcriptional regulator
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
PF00781 (1/2) Diacylglycerol kinase catalytic domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces griseochromogenes 1118.45 +- 427.23 4 0 2 3 0.05 +- 0.16 4 2

PF00005 (3/4) ABC transporter
PF00664 (2/4) ABC transporter transmembrane region
Streptomyces fradiae 361.59 +- 147.35 5 0 2 3 0.03 +- 0.10 5 2

PF07690 (3/5) Major Facilitator Superfamily
PF04055 (3/5) Radical SAM superfamily
Streptomyces rimosus subsp. rimosus ATCC 10970 243.75 +- 113.75 2 0 1 0 0.03 +- 0.01 2 19

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12833 (1/2) Helix-turn-helix domain
PF03621 (1/2) MbtH-like protein
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02311 (1/2) AraC-like ligand binding domain
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00005 (1/2) ABC transporter
Streptomyces sp. 3211.1 961.81 +- 1674.31 6 0 3 3 0.03 +- 0.06 6

No common domains found
Streptomyces sp. ADI93-02 314.58 +- 326.85 3 0 0 0 0.05 +- 0.08 3

No common domains found
Streptomyces sp. Ru87 211.02 +- 229.41 3 0 0 1 0.08 +- 0.14 3 1

PF00534 (2/3) Glycosyl transferases group 1
Streptomyces capuensis 131.15 +- 44.17 3 0 1 1 0.03 +- 0.04 3

No common domains found
Streptomyces sp. 3211.6 659.57 +- 501.43 2 0 2 1 0.05 +- 0.11 2 28

PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF13641 (1/2) Glycosyltransferase like family 2
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (1/2) WYL domain
PF10823 (1/2) Protein of unknown function (DUF2568)
PF09335 (1/2) SNARE associated Golgi protein
PF08279 (1/2) HTH domain
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04672 (1/2) S-adenosyl methyltransferase
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF01810 (1/2) LysE type translocator
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (1/2) GTP cyclohydrolase II
PF00730 (1/2) HhH-GPD superfamily base excision DNA repair protein
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00400 (1/2) WD domain, G-beta repeat
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00152 (1/2) tRNA synthetases class II (D, K and N)
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
Streptomyces sp. CNQ865 621.11 +- 413.12 3 0 1 0 0.01 +- 0.00 3

No common domains found
Streptomyces sp. CB03578 946.35 +- 1049.91 5 0 1 1 0.03 +- 0.04 5

No common domains found
Streptomyces lividans 1326 137.00 +- 97.00 2 0 1 1 0.05 +- 0.04 2 15

TIGR04451 (1/2) lantipeptide, SCO0268 family
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF11303 (1/2) Protein of unknown function (DUF3105)
PF09335 (1/2) SNARE associated Golgi protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF02388 (1/2) FemAB family
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00480 (1/2) ROK family
Streptomyces luteocolor 675.20 +- 959.81 5 0 3 1 0.02 +- 0.03 5

No common domains found
Streptomyces niveus 584.29 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF13560 (1/1) Helix-turn-helix domain
PF13424 (1/1) Tetratricopeptide repeat
PF13411 (1/1) MerR HTH family regulatory protein
PF10026 (1/1) Predicted Zn-dependent protease (DUF2268)
PF08386 (1/1) TAP-like protein
PF07739 (1/1) TipAS antibiotic-recognition domain
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
Streptomyces avermitilis MA-4680 = NBRC 14893 192.17 +- 107.96 4 0 2 0 0.03 +- 0.04 4 2

PF07690 (2/4) Major Facilitator Superfamily
PF00348 (2/4) Polyprenyl synthetase
Streptomyces sp. NRRL F-5727 325.00 +- 130.00 2 0 1 1 0.04 +- 0.02 2 24

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13535 (1/2) ATP-grasp domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00106 (1/2) short chain dehydrogenase
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces sp. AVP053U2 365.24 +- 368.41 3 0 0 0 0.06 +- 0.16 3 2

PF01636 (2/3) Phosphotransferase enzyme family
PF00005 (2/3) ABC transporter
Streptomyces sp. WM4235 336.71 +- 263.79 3 0 1 1 0.04 +- 0.10 3

No common domains found
Streptomyces olivaceus 252.97 +- 0.00 1 0 1 1 0.09 +- 0.25 1 11

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13601 (1/1) Winged helix DNA-binding domain
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04820 (1/1) Tryptophan halogenase
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces parvulus 43.00 +- 0.00 1 0 0 0 0.05 +- 0.04 1 2

PF01872 (1/1) RibD C-terminal domain
PF00383 (1/1) Cytidine and deoxycytidylate deaminase zinc-binding region
Streptomyces sp. NEAU-LD23 516.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 12

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF12697 (1/2) Alpha/beta hydrolase family
PF11706 (1/2) CGNR zinc finger
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07336 (1/2) Putative stress-induced transcription regulator
PF01613 (1/2) Flavin reductase like domain
PF01381 (1/2) Helix-turn-helix
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00239 (1/2) Resolvase, N terminal domain
Streptomyces sp. CB03911 796.26 +- 610.92 3 0 1 1 0.02 +- 0.02 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. Sge12 258.72 +- 14.97 2 0 1 0 0.06 +- 0.16 2 17

TIGR03797 (1/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (1/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13459 (1/2) 4Fe-4S single cluster domain
PF13437 (1/2) HlyD family secretion protein
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF10589 (1/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/2) TAP-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF05013 (1/2) N-formylglutamate amidohydrolase
PF03640 (1/2) Secreted repeat of unknown function
PF03412 (1/2) Peptidase C39 family
PF03055 (1/2) Retinal pigment epithelial membrane protein
PF01512 (1/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00664 (1/2) ABC transporter transmembrane region
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter
Streptomyces sp. NBRC 109706 767.23 +- 830.75 3 0 2 1 0.01 +- 0.01 3

No common domains found
Streptomyces sp. CNQ431 1170.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 13

TIGR01733 (1/1) amino acid adenylation domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/1) Enolase C-terminal domain-like
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12146 (1/1) Serine aminopeptidase, S33
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (1/1) GH3 auxin-responsive promoter
PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00694 (1/1) Aconitase C-terminal domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00330 (1/1) Aconitase family (aconitate hydratase)
Streptomyces sp. SA15 175.87 +- 64.46 3 0 0 0 0.08 +- 0.14 3

No common domains found
Streptomyces ambofaciens 67.10 +- 0.00 1 0 0 0 0.06 +- 0.08 1 1

PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces pini 35.86 +- 0.00 1 0 0 1 0.06 +- 0.07 1 3

PF13581 (1/1) Histidine kinase-like ATPase domain
PF04055 (1/1) Radical SAM superfamily
PF01928 (1/1) CYTH domain
Streptomyces mediolani 715.00 +- 0.00 1 0 0 0 0.03 +- 0.01 1 7

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. FxanaA7 113.64 +- 58.36 2 0 1 1 0.05 +- 0.05 2 8

TIGR01910 (1/2) peptidase, ArgE/DapE family
PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (1/2) Peptidase family M20/M25/M40
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
Streptomyces sp. Root431 726.06 +- 500.77 4 0 1 2 0.02 +- 0.01 4 1

PF07690 (2/4) Major Facilitator Superfamily
Streptomyces sp. 5112.2 696.60 +- 0.00 1 0 1 1 0.01 +- 0.00 1 11

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (1/1) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (1/1) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (1/1) HlyD family secretion protein
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces sp. SM18 462.25 +- 247.25 2 0 1 0 0.01 +- 0.01 2 14

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13407 (1/2) Periplasmic binding protein domain
PF07702 (1/2) UTRA domain
PF06737 (1/2) Transglycosylase-like domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01476 (1/2) LysM domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter
Streptomyces antimycoticus 212.47 +- 0.00 1 0 0 0 0.04 +- 0.05 1 9

TIGR00350 (1/1) cell envelope-related function transcriptional attenuator common domain
PF13399 (1/1) LytR cell envelope-related transcriptional attenuator
PF07859 (1/1) alpha/beta hydrolase fold
PF03816 (1/1) Cell envelope-related transcriptional attenuator domain
PF03807 (1/1) NADP oxidoreductase coenzyme F420-dependent
PF01258 (1/1) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (1/1) D-alanyl-D-alanine carboxypeptidase
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00459 (1/1) Inositol monophosphatase family
Streptomyces sp. CS131 711.34 +- 62.66 2 0 2 2 0.02 +- 0.03 2 13

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13377 (1/2) Periplasmic binding protein-like domain
PF12730 (1/2) ABC-2 family transporter protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
Streptomyces corchorusii 463.82 +- 365.79 4 0 2 0 0.01 +- 0.02 4

No common domains found
Streptomyces sp. CS147 336.52 +- 0.00 1 0 1 1 0.03 +- 0.03 1 6

PF05147 (1/1) Lanthionine synthetase C-like protein
PF04672 (1/1) S-adenosyl methyltransferase
PF00664 (1/1) ABC transporter transmembrane region
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces sp. SPMA113 282.06 +- 245.26 3 0 1 0 0.02 +- 0.01 3 2

PF14759 (2/3) Reductase C-terminal
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
Streptomyces sp. HPH0547 35.45 +- 0.00 1 0 0 0 0.08 +- 0.12 1 5

PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
Streptomyces albulus 594.27 +- 356.75 6 0 1 1 0.02 +- 0.02 6

No common domains found
Streptomyces sp. CS081A 224.15 +- 85.45 2 0 1 0 0.04 +- 0.12 2 28

TIGR02124 (1/2) hydrogenase expression/formation protein HypE
TIGR01891 (1/2) amidohydrolase
TIGR00709 (1/2) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/2) carbamoyltransferase HypF
PF17788 (1/2) HypF Kae1-like domain
PF13535 (1/2) ATP-grasp domain
PF13374 (1/2) Tetratricopeptide repeat
PF13191 (1/2) AAA ATPase domain
PF12680 (1/2) SnoaL-like domain
PF10502 (1/2) Signal peptidase, peptidase S26
PF07690 (1/2) Major Facilitator Superfamily
PF07503 (1/2) HypF finger
PF07291 (1/2) Methylamine utilisation protein MauE
PF05977 (1/2) Transmembrane secretion effector
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF02254 (1/2) TrkA-N domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01300 (1/2) Telomere recombination
PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase
PF00857 (1/2) Isochorismatase family
PF00717 (1/2) Peptidase S24-like
PF00708 (1/2) Acylphosphatase
PF00664 (1/2) ABC transporter transmembrane region
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter
Streptomyces sp. Ag82_O1-9 221.43 +- 286.26 4 0 1 0 0.04 +- 0.08 4 1

PF18085 (2/4) Maltokinase N-terminal cap domain
Streptomyces sp. San01 191.87 +- 107.74 2 0 0 0 0.06 +- 0.06 2 25

PF01546 (2/2) Peptidase family M20/M25/M40
TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01910 (1/2) peptidase, ArgE/DapE family
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13520 (1/2) Amino acid permease
PF13378 (1/2) Enolase C-terminal domain-like
PF13354 (1/2) Beta-lactamase enzyme family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07969 (1/2) Amidohydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF03061 (1/2) Thioesterase superfamily
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (1/2) Prolyl oligopeptidase family
PF00202 (1/2) Aminotransferase class-III
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00005 (1/2) ABC transporter
Streptomyces sp. AmelKG-E11A 405.43 +- 0.00 1 0 1 0 0.03 +- 0.03 1 8

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF09265 (1/1) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF06236 (1/1) Tyrosinase co-factor MelC1
PF01565 (1/1) FAD binding domain
PF01156 (1/1) Inosine-uridine preferring nucleoside hydrolase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00294 (1/1) pfkB family carbohydrate kinase
PF00264 (1/1) Common central domain of tyrosinase
Streptomyces sp. PRh5 163.58 +- 75.48 3 0 0 0 0.05 +- 0.05 3

No common domains found
Streptomyces fimicarius 268.60 +- 186.69 2 0 1 1 0.06 +- 0.06 2 12

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13411 (1/2) MerR HTH family regulatory protein
PF12730 (1/2) ABC-2 family transporter protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03476 (1/2) MOSC N-terminal beta barrel domain
PF03473 (1/2) MOSC domain
PF03412 (1/2) Peptidase C39 family
PF01551 (1/2) Peptidase family M23
PF00664 (1/2) ABC transporter transmembrane region
PF00248 (1/2) Aldo/keto reductase family
PF00005 (1/2) ABC transporter
Streptomyces sp. XY58 531.82 +- 0.00 1 0 0 0 0.03 +- 0.01 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces sp. 74 158.81 +- 2.44 2 0 0 0 0.05 +- 0.05 2 21

TIGR01766 (1/2) transposase, IS605 OrfB family
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF07971 (1/2) Glycosyl hydrolase family 92
PF07282 (1/2) Putative transposase DNA-binding domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02057 (1/2) Glycosyl hydrolase family 59
PF01385 (1/2) Probable transposase
PF01229 (1/2) Glycosyl hydrolases family 39
PF00672 (1/2) HAMP domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00553 (1/2) Cellulose binding domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00331 (1/2) Glycosyl hydrolase family 10
PF00072 (1/2) Response regulator receiver domain
Streptomyces thermovulgaris 1548.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 9

TIGR04353 (1/1) PqqD family protein, HPr-rel-A system
PF13646 (1/1) HEAT repeats
PF13471 (1/1) Transglutaminase-like superfamily
PF13411 (1/1) MerR HTH family regulatory protein
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. P3 422.69 +- 228.50 3 0 1 1 0.06 +- 0.16 3 1

PF00005 (2/3) ABC transporter
Streptomyces africanus 405.29 +- 374.71 2 0 1 1 0.01 +- 0.03 2 12

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR03892 (1/2) thiazolylpeptide-type bacteriocin precursor
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF06821 (1/2) Serine hydrolase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04055 (1/2) Radical SAM superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02310 (1/2) B12 binding domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. CNY243 354.16 +- 244.08 4 0 2 0 0.05 +- 0.08 4

No common domains found
Streptomyces capuensis 71.86 +- 41.63 3 0 2 1 0.08 +- 0.08 3

No common domains found
Streptomyces sp. MP131-18 217.69 +- 0.00 1 0 1 1 0.06 +- 0.07 1 9

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF12802 (1/1) MarR family
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
Streptomyces hygroscopicus subsp. hygroscopicus 239.66 +- 136.25 6 0 0 0 0.04 +- 0.05 6 1

PF07690 (3/6) Major Facilitator Superfamily
Streptomyces sp. NRRL WC-3795 404.00 +- 238.14 2 0 0 0 0.03 +- 0.02 2 20

TIGR00928 (1/2) adenylosuccinate lyase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13460 (1/2) NAD(P)H-binding
PF12800 (1/2) 4Fe-4S binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01494 (1/2) FAD binding domain
PF01425 (1/2) Amidase
PF00703 (1/2) Glycosyl hydrolases family 2
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00072 (1/2) Response regulator receiver domain
Streptomyces lavendulae subsp. lavendulae 1334.14 +- 511.29 4 0 3 0 0.01 +- 0.01 4 7

PF13649 (3/4) Methyltransferase domain
PF05193 (3/4) Peptidase M16 inactive domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF00005 (3/4) ABC transporter
PF17914 (2/4) HopA1 effector protein family
PF02441 (2/4) Flavoprotein
PF01636 (2/4) Phosphotransferase enzyme family
Streptomyces sp. XY37 531.82 +- 0.00 1 0 0 0 0.03 +- 0.01 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces turgidiscabies 140.70 +- 66.23 5 0 0 1 0.06 +- 0.07 5

No common domains found
Streptomyces sp. PanSC9 251.55 +- 0.00 1 0 0 0 0.05 +- 0.01 1 17

PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08386 (1/1) TAP-like protein
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/1) Cupin domain
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01636 (1/1) Phosphotransferase enzyme family
PF01593 (1/1) Flavin containing amine oxidoreductase
PF01381 (1/1) Helix-turn-helix
PF00561 (1/1) alpha/beta hydrolase fold
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (1/1) Aminotransferase class-III
PF00171 (1/1) Aldehyde dehydrogenase family
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces noursei ATCC 11455 1376.96 +- 1872.70 5 0 2 0 0.02 +- 0.02 5

No common domains found
Streptomyces sp. SCSIO 03032 451.50 +- 0.00 1 0 1 0 0.01 +- 0.00 1 5

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF02310 (1/1) B12 binding domain
PF00326 (1/1) Prolyl oligopeptidase family
Streptomyces sp. CNS606 97.13 +- 73.68 2 0 1 1 0.08 +- 0.07 2 11

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
Streptomyces europaeiscabiei 196.81 +- 147.19 2 0 0 0 0.04 +- 0.03 2 14

PF13478 (1/2) XdhC Rossmann domain
PF09339 (1/2) IclR helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (1/2) XdhC and CoxI family
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00561 (1/2) alpha/beta hydrolase fold
PF00296 (1/2) Luciferase-like monooxygenase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. CB02130 706.54 +- 331.59 3 0 2 1 0.04 +- 0.06 3 1

PF00005 (3/3) ABC transporter
Streptomyces sp. WAC06614 65.00 +- 0.00 1 0 0 0 0.03 +- 0.02 1 3

TIGR03619 (1/1) probable F420-dependent oxidoreductase, Rv2161c family
PF01814 (1/1) Hemerythrin HHE cation binding domain
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces stelliscabiei 144.48 +- 0.00 1 0 0 0 0.06 +- 0.06 1 7

PF17900 (1/1) Peptidase M1 N-terminal domain
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (1/1) DJ-1/PfpI family
PF01433 (1/1) Peptidase family M1 domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00082 (1/1) Subtilase family
Streptomyces sp. 19 184.29 +- 0.00 1 0 1 1 0.06 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces sp. NRRL S-378 340.31 +- 456.82 4 0 0 0 0.04 +- 0.05 4 3

PF07690 (2/4) Major Facilitator Superfamily
PF00440 (2/4) Bacterial regulatory proteins, tetR family
PF00067 (2/4) Cytochrome P450
Streptomyces sp. Cmuel-A718b 686.05 +- 83.95 2 0 2 2 0.03 +- 0.03 2 13

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13377 (1/2) Periplasmic binding protein-like domain
PF12730 (1/2) ABC-2 family transporter protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
Streptomyces dioscori 624.48 +- 646.35 4 0 2 2 0.05 +- 0.08 4 2

PF07690 (2/4) Major Facilitator Superfamily
PF00486 (2/4) Transcriptional regulatory protein, C terminal
Streptomyces sp. SAI-097 68.76 +- 5.52 2 0 1 0 0.08 +- 0.04 2 11

TIGR02133 (1/2) ribose 5-phosphate isomerase
PF16896 (1/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02734 (1/2) DAK2 domain
PF02733 (1/2) Dak1 domain
PF02502 (1/2) Ribose/Galactose Isomerase
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00121 (1/2) Triosephosphate isomerase
Streptomyces ambofaciens ATCC 23877 516.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 1

PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces reticuliscabiei 334.55 +- 147.68 3 0 0 1 0.03 +- 0.07 3

No common domains found
Streptomyces sp. OK228 911.66 +- 731.76 7 0 1 0 0.02 +- 0.05 7

No common domains found
Streptomyces albidoflavus 161.25 +- 0.00 1 0 0 0 0.01 +- 0.01 1 5

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00931 (1/1) NB-ARC domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces albidoflavus 416.79 +- 0.00 1 0 1 0 0.10 +- 0.15 1 28

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces sp. 59 192.12 +- 144.86 5 0 2 0 0.05 +- 0.16 5

No common domains found
Streptomyces fulvissimus DSM 40593 433.75 +- 32.28 2 0 2 0 0.06 +- 0.15 2 36

PF00005 (2/2) ABC transporter
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13115 (1/2) YtkA-like
PF12697 (1/2) Alpha/beta hydrolase family
PF12679 (1/2) ABC-2 family transporter protein
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/2) Amidohydrolase
PF04389 (1/2) Peptidase family M28
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02222 (1/2) ATP-grasp domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01676 (1/2) Metalloenzyme superfamily
PF01144 (1/2) Coenzyme A transferase
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces niveus 520.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 8

PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00550 (1/1) Phosphopantetheine attachment site
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Streptomyces sp. b62 1665.00 +- 675.00 2 0 1 1 0.01 +- 0.00 2 15

PF00005 (2/2) ABC transporter
TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12679 (1/2) ABC-2 family transporter protein
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF03412 (1/2) Peptidase C39 family
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00296 (1/2) Luciferase-like monooxygenase
Streptomyces melanosporofaciens 1271.11 +- 0.00 1 0 0 0 0.01 +- 0.00 1 8

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF02983 (1/1) Alpha-lytic protease prodomain
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/1) Luciferase-like monooxygenase
PF00089 (1/1) Trypsin
PF00005 (1/1) ABC transporter
Streptomyces sp. TAA040 127.68 +- 0.00 1 0 0 0 0.09 +- 0.07 1 7

TIGR01972 (1/1) proton-translocating NADH-quinone oxidoreductase, chain M
PF13581 (1/1) Histidine kinase-like ATPase domain
PF00507 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/1) Proton-conducting membrane transporter
PF00146 (1/1) NADH dehydrogenase
Streptomyces sp. CB09001 204.75 +- 169.83 2 0 0 1 0.06 +- 0.10 2 22

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (1/2) FAD-NAD(P)-binding
PF12006 (1/2) Protein of unknown function (DUF3500)
PF07920 (1/2) Protein of unknown function (DUF1684)
PF07690 (1/2) Major Facilitator Superfamily
PF06912 (1/2) Protein of unknown function (DUF1275)
PF04055 (1/2) Radical SAM superfamily
PF03737 (1/2) Aldolase/RraA
PF02983 (1/2) Alpha-lytic protease prodomain
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF01494 (1/2) FAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00160 (1/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00155 (1/2) Aminotransferase class I and II
PF00089 (1/2) Trypsin
PF00005 (1/2) ABC transporter
Streptomyces filamentosus NRRL 11379 668.57 +- 0.00 1 0 1 1 0.03 +- 0.01 1 8

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces acidiscabies 417.31 +- 63.89 3 0 1 0 0.05 +- 0.19 3 2

PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
Streptomyces puniciscabiei 371.73 +- 323.85 3 0 1 1 0.04 +- 0.03 3

No common domains found
Streptomyces autolyticus 193.50 +- 0.00 1 0 0 0 0.02 +- 0.02 1 6

PF14759 (1/1) Reductase C-terminal
PF14016 (1/1) Protein of unknown function (DUF4232)
PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Streptomyces albidoflavus 175.38 +- 0.00 1 0 0 0 0.07 +- 0.11 1 15

TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (1/1) Domain of unknown function (DUF4380)
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13407 (1/1) Periplasmic binding protein domain
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF01081 (1/1) KDPG and KHG aldolase
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00107 (1/1) Zinc-binding dehydrogenase
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL S-1813 642.50 +- 832.93 3 0 1 1 0.04 +- 0.09 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. 4121.5 283.02 +- 136.54 4 0 1 2 0.04 +- 0.06 4

No common domains found
Streptomyces sp. CB00316 942.43 +- 998.33 3 0 2 0 0.04 +- 0.16 3 2

PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter
Streptomyces sp. CS014 1955.65 +- 1435.65 2 0 2 1 0.01 +- 0.03 2 24

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF13203 (1/2) Putative metallopeptidase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12730 (1/2) ABC-2 family transporter protein
PF12697 (1/2) Alpha/beta hydrolase family
PF09967 (1/2) VWA-like domain (DUF2201)
PF08242 (1/2) Methyltransferase domain
PF07730 (1/2) Histidine kinase
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF06722 (1/2) Protein of unknown function (DUF1205)
PF03621 (1/2) MbtH-like protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. pseudoverticillatus 759.18 +- 1395.80 7 0 4 2 0.05 +- 0.13 7

No common domains found
Streptomyces scabiei 392.10 +- 367.46 6 0 2 1 0.04 +- 0.15 6

No common domains found
Streptomyces rimosus subsp. rimosus 124.03 +- 35.65 3 0 1 1 0.03 +- 0.02 3

No common domains found
Streptomyces purpeochromogenes 241.43 +- 0.00 1 0 0 0 0.02 +- 0.01 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces griseorubens 23.11 +- 0.00 1 0 0 0 0.09 +- 0.08 1 2

PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF03713 (1/1) Domain of unknown function (DUF305)
Streptomyces aquilus 532.12 +- 467.62 2 0 0 1 0.05 +- 0.17 2 30

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (1/2) Methyltransferase domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF12006 (1/2) Protein of unknown function (DUF3500)
PF05331 (1/2) Protein of unknown function (DUF742)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04672 (1/2) S-adenosyl methyltransferase
PF03457 (1/2) Helicase associated domain
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01636 (1/2) Phosphotransferase enzyme family
PF01590 (1/2) GAF domain
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (1/2) NUDIX domain
PF00271 (1/2) Helicase conserved C-terminal domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces sp. ZFG47 214.50 +- 171.99 5 0 1 1 0.05 +- 0.08 5

No common domains found
Streptomyces sp. NRRL F-5650 1554.07 +- 2002.71 3 0 0 0 0.03 +- 0.04 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. 70 14352.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 21

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/1) amidohydrolase
PF14310 (1/1) Fibronectin type III-like domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF07730 (1/1) Histidine kinase
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01915 (1/1) Glycosyl hydrolase family 3 C-terminal domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01061 (1/1) ABC-2 type transporter
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00067 (1/1) Cytochrome P450
PF00005 (1/1) ABC transporter
Streptomyces tsukubensis 128.95 +- 73.67 2 0 0 1 0.09 +- 0.07 2 25

TIGR01733 (1/2) amino acid adenylation domain
PF18029 (1/2) Glyoxalase-like domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13471 (1/2) Transglutaminase-like superfamily
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08713 (1/2) DNA alkylation repair enzyme
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF07478 (1/2) D-ala D-ala ligase C-terminus
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (1/2) D-ala D-ala ligase N-terminus
PF01494 (1/2) FAD binding domain
PF00975 (1/2) Thioesterase domain
PF00850 (1/2) Histone deacetylase domain
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00733 (1/2) Asparagine synthase
PF00698 (1/2) Acyl transferase domain
PF00551 (1/2) Formyl transferase
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00155 (1/2) Aminotransferase class I and II
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
Streptomyces sp. DconLS 300.26 +- 323.57 5 0 2 0 0.05 +- 0.16 5 1

PF07690 (3/5) Major Facilitator Superfamily
Streptomyces resistomycificus 572.85 +- 77.15 2 0 0 0 0.04 +- 0.11 2 30

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
TIGR03567 (1/2) FMN reductase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01484 (1/2) HAD hydrolase, family IIB
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain
PF14559 (1/2) Tetratricopeptide repeat
PF13535 (1/2) ATP-grasp domain
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (1/2) Tetratricopeptide repeat
PF13424 (1/2) Tetratricopeptide repeat
PF09334 (1/2) tRNA synthetases class I (M)
PF08282 (1/2) haloacid dehalogenase-like hydrolase
PF08281 (1/2) Sigma-70, region 4
PF07883 (1/2) Cupin domain
PF04542 (1/2) Sigma-70 region 2
PF03358 (1/2) NADPH-dependent FMN reductase
PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (1/2) MGS-like domain
PF01808 (1/2) AICARFT/IMPCHase bienzyme
PF01613 (1/2) Flavin reductase like domain
PF01259 (1/2) SAICAR synthetase
PF00709 (1/2) Adenylosuccinate synthetase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00106 (1/2) short chain dehydrogenase
Streptomyces fragilis 480.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 8

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces sp. XY431 387.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 10

TIGR03822 (1/1) lysine-2,3-aminomutase-related protein
PF18604 (1/1) Pre ATP-grasp domain
PF18105 (1/1) PGM1 C-terminal domain
PF13649 (1/1) Methyltransferase domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF12697 (1/1) Alpha/beta hydrolase family
PF12544 (1/1) Lysine-2,3-aminomutase
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF00144 (1/1) Beta-lactamase
Streptomyces albus subsp. albus 738.95 +- 0.00 1 0 1 1 0.01 +- 0.00 1 9

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF13649 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF05193 (1/1) Peptidase M16 inactive domain
PF04989 (1/1) Cephalosporin hydroxylase
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF00805 (1/1) Pentapeptide repeats (8 copies)
PF00675 (1/1) Insulinase (Peptidase family M16)
Streptomyces sp. NWU339 1020.39 +- 895.05 3 0 0 0 0.03 +- 0.09 3 2

PF00775 (2/3) Dioxygenase
PF00378 (2/3) Enoyl-CoA hydratase/isomerase
Streptomyces scabiei 672.64 +- 617.36 2 0 0 0 0.02 +- 0.04 2 12

TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02036 (1/2) SCP-2 sterol transfer family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter
Streptomyces sp. ADI98-10 487.50 +- 0.00 1 0 1 1 0.02 +- 0.02 1 6

PF05147 (1/1) Lanthionine synthetase C-like protein
PF04672 (1/1) S-adenosyl methyltransferase
PF00664 (1/1) ABC transporter transmembrane region
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces sp. ms184 52.30 +- 0.00 1 0 0 0 0.10 +- 0.10 1 2

PF17964 (1/1) Bacterial Ig domain
PF03734 (1/1) L,D-transpeptidase catalytic domain
Streptomyces sp. 2314.4 306.56 +- 112.53 4 0 2 1 0.04 +- 0.17 4 3

PF07690 (3/4) Major Facilitator Superfamily
PF00535 (2/4) Glycosyl transferase family 2
PF00196 (2/4) Bacterial regulatory proteins, luxR family
Streptomyces sp. NWU49 279.00 +- 186.14 2 0 0 1 0.06 +- 0.09 2 16

PF00005 (2/2) ABC transporter
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF12450 (1/2) von Willebrand factor
PF12034 (1/2) Domain of unknown function (DUF3520)
PF10502 (1/2) Signal peptidase, peptidase S26
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00717 (1/2) Peptidase S24-like
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00092 (1/2) von Willebrand factor type A domain
Streptomyces sp. WAC01280 1027.12 +- 1027.69 6 0 2 3 0.01 +- 0.01 6 1

PF07690 (3/6) Major Facilitator Superfamily
Streptomyces rimosus subsp. rimosus 241.83 +- 220.09 6 0 0 2 0.06 +- 0.10 6

No common domains found
Streptomyces luridiscabiei 438.94 +- 287.53 2 0 1 0 0.07 +- 0.19 2 28

TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR00218 (1/2) mannose-6-phosphate isomerase, class I
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13115 (1/2) YtkA-like
PF12697 (1/2) Alpha/beta hydrolase family
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02222 (1/2) ATP-grasp domain
PF01676 (1/2) Metalloenzyme superfamily
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01238 (1/2) Phosphomannose isomerase type I
PF00703 (1/2) Glycosyl hydrolases family 2
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00403 (1/2) Heavy-metal-associated domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter
Streptomyces scabiei 75.82 +- 32.82 2 0 0 0 0.09 +- 0.14 2 14

TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02036 (1/2) SCP-2 sterol transfer family
PF00430 (1/2) ATP synthase B/B' CF(0)
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter
Streptomyces sp. NRRL S-1824 448.72 +- 157.48 6 0 0 0 0.03 +- 0.08 6 1

PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
Streptomyces antibioticus 287.48 +- 226.00 3 0 0 0 0.03 +- 0.07 3

No common domains found
Streptomyces sp. NRRL F-2305 98.11 +- 0.00 1 0 0 0 0.04 +- 0.03 1 8

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
Streptomyces sp. CC0208 506.67 +- 561.21 3 0 1 1 0.02 +- 0.02 3

No common domains found
Streptomyces achromogenes subsp. achromogenes 390.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 4

PF02737 (1/1) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (1/1) Flavin reductase like domain
PF00725 (1/1) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces sp. WZ.A104 699.69 +- 118.21 3 0 2 1 0.04 +- 0.06 3 1

PF00005 (2/3) ABC transporter
Streptomyces rubidus 101.74 +- 0.00 1 0 0 0 0.04 +- 0.08 1 9

PF18130 (1/1) ATP-grasp N-terminal domain
PF16259 (1/1) Domain of unknown function (DUF4913)
PF13620 (1/1) Carboxypeptidase regulatory-like domain
PF13535 (1/1) ATP-grasp domain
PF12307 (1/1) Protein of unknown function (DUF3631)
PF07690 (1/1) Major Facilitator Superfamily
PF03771 (1/1) Domain of unknown function (DUF317)
PF01638 (1/1) HxlR-like helix-turn-helix
PF01555 (1/1) DNA methylase
Streptomyces sp. ADI96-15 218.20 +- 39.80 2 0 1 1 0.05 +- 0.07 2 16

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/2) AAA ATPase domain
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00877 (1/2) NlpC/P60 family
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter
Streptomyces sp. BK022 89.58 +- 0.00 1 0 1 0 0.06 +- 0.05 1 5

PF17900 (1/1) Peptidase M1 N-terminal domain
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF01433 (1/1) Peptidase family M1 domain
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00293 (1/1) NUDIX domain
Streptomyces scopuliridis RB72 650.00 +- 455.00 2 0 0 0 0.02 +- 0.00 2 23

TIGR00229 (1/2) PAS domain S-box protein
PF17148 (1/2) Domain of unknown function (DUF5117)
PF16353 (1/2) Domain of unknown function(DUF4981)
PF16313 (1/2) Met-zincin
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13426 (1/2) PAS domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF13185 (1/2) GAF domain
PF08448 (1/2) PAS fold
PF07702 (1/2) UTRA domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF06452 (1/2) Carbohydrate family 9 binding domain-like
PF02929 (1/2) Beta galactosidase small chain
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
Streptomyces alboflavus 474.78 +- 305.22 2 0 1 0 0.02 +- 0.00 2 19

TIGR01490 (1/2) HAD hydrolase, family IB
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF07690 (1/2) Major Facilitator Superfamily
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01937 (1/2) Protein of unknown function DUF89
PF01494 (1/2) FAD binding domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00891 (1/2) O-methyltransferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00248 (1/2) Aldo/keto reductase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
Streptomyces violaceusniger 146.27 +- 8.62 2 0 0 0 0.06 +- 0.08 2 18

TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00350 (1/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF03816 (1/2) Cell envelope-related transcriptional attenuator domain
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01258 (1/2) Prokaryotic dksA/traR C4-type zinc finger
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00459 (1/2) Inositol monophosphatase family
PF00005 (1/2) ABC transporter
Streptomyces sp. XY332 43.00 +- 0.00 1 0 1 0 0.05 +- 0.04 1 3

PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Streptomyces sp. NP10 650.72 +- 656.33 3 0 1 1 0.03 +- 0.06 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. JHA26 2882.61 +- 0.00 1 0 1 0 0.01 +- 0.01 1 16

TIGR01830 (1/1) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (1/1) amino acid adenylation domain
TIGR01720 (1/1) non-ribosomal peptide synthase domain TIGR01720
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13279 (1/1) Thioesterase-like superfamily
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12146 (1/1) Serine aminopeptidase, S33
PF07977 (1/1) FabA-like domain
PF07508 (1/1) Recombinase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01323 (1/1) DSBA-like thioredoxin domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
Streptomyces sp. NRRL S-623 134.43 +- 171.14 4 0 1 0 0.07 +- 0.17 4 1

PF00082 (2/4) Subtilase family
Streptomyces griseofuscus 321.24 +- 0.00 1 0 1 0 0.10 +- 0.22 1 26

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF14237 (1/1) GYF domain 2
PF13421 (1/1) SPFH domain-Band 7 family
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03824 (1/1) High-affinity nickel-transport protein
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
Streptomyces sp. Ru73 53.77 +- 24.23 2 0 0 0 0.05 +- 0.09 2 7

PF14759 (1/2) Reductase C-terminal
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/2) Cupin domain
PF01381 (1/2) Helix-turn-helix
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00083 (1/2) Sugar (and other) transporter
Streptomyces lavendulae subsp. lavendulae 73.80 +- 12.86 2 0 1 1 0.06 +- 0.06 2 12

PF14158 (1/2) YndJ-like protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13492 (1/2) GAF domain
PF13471 (1/2) Transglutaminase-like superfamily
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00733 (1/2) Asparagine synthase
PF00149 (1/2) Calcineurin-like phosphoesterase
Streptomyces sp. CB02261 151.67 +- 0.00 1 0 1 1 0.02 +- 0.01 1 4

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02897 (1/1) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (1/1) Prolyl oligopeptidase family
Streptomyces katrae 80.29 +- 11.47 2 0 1 0 0.04 +- 0.04 2 7

TIGR03296 (1/2) M6 family metalloprotease domain
PF13649 (1/2) Methyltransferase domain
PF06737 (1/2) Transglycosylase-like domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
Streptomyces sp. NRRL WC-3605 230.00 +- 160.00 2 0 0 0 0.04 +- 0.04 2 15

PF00082 (2/2) Subtilase family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
PF13191 (1/2) AAA ATPase domain
PF07729 (1/2) FCD domain
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (1/2) Putative Ig domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (1/2) PA domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00221 (1/2) Aromatic amino acid lyase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces cinnamoneus 516.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 7

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (1/1) luciferase family oxidoreductase, group 1
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. 844.5 409.88 +- 324.50 4 0 1 1 0.04 +- 0.07 4 1

PF00005 (2/4) ABC transporter
Streptomyces albireticuli 534.60 +- 431.67 3 0 3 1 0.02 +- 0.02 3 1

PF00005 (2/3) ABC transporter
Streptomyces albidoflavus 76.10 +- 0.00 1 0 1 0 0.05 +- 0.00 1 12

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
PF18130 (1/1) ATP-grasp N-terminal domain
PF13640 (1/1) 2OG-Fe(II) oxygenase superfamily
PF13535 (1/1) ATP-grasp domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07993 (1/1) Male sterility protein
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00106 (1/1) short chain dehydrogenase
Streptomyces sp. Ru71 234.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 4

PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF01266 (1/1) FAD dependent oxidoreductase
PF00474 (1/1) Sodium:solute symporter family
Streptomyces viridochromogenes 559.00 +- 351.00 2 0 1 0 0.02 +- 0.02 2 31

TIGR03425 (1/2) urea carboxylase-associated protein 2
TIGR03424 (1/2) urea carboxylase-associated protein 1
TIGR02712 (1/2) urea carboxylase
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13520 (1/2) Amino acid permease
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13394 (1/2) 4Fe-4S single cluster domain
PF09347 (1/2) Domain of unknown function (DUF1989)
PF07690 (1/2) Major Facilitator Superfamily
PF06508 (1/2) Queuosine biosynthesis protein QueC
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF02803 (1/2) Thiolase, C-terminal domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02682 (1/2) Carboxyltransferase domain, subdomain C and D
PF02626 (1/2) Carboxyltransferase domain, subdomain A and B
PF02310 (1/2) B12 binding domain
PF01425 (1/2) Amidase
PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (1/2) GTP cyclohydrolase I
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00108 (1/2) Thiolase, N-terminal domain
Streptomyces lushanensis 845.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 8

PF13400 (1/1) Putative Flp pilus-assembly TadE/G-like
PF07730 (1/1) Histidine kinase
PF07591 (1/1) Pretoxin HINT domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00691 (1/1) OmpA family
PF00482 (1/1) Type II secretion system (T2SS), protein F
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
Streptomyces sp. CNT318 614.55 +- 0.00 1 0 1 1 0.08 +- 0.24 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter
Streptomyces anulatus 218.17 +- 133.41 3 0 1 1 0.03 +- 0.04 3

No common domains found
Streptomyces sp. CB01580 99.13 +- 4.07 2 0 0 0 0.05 +- 0.04 2 13

TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
PF13621 (1/2) Cupin-like domain
PF12740 (1/2) Chlorophyllase enzyme
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (1/2) DmpG-like communication domain
PF07690 (1/2) Major Facilitator Superfamily
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (1/2) HMGL-like
PF00155 (1/2) Aminotransferase class I and II
PF00135 (1/2) Carboxylesterase family
Streptomyces sp. NRRL F-6131 612.37 +- 199.48 5 0 3 2 0.05 +- 0.17 5 1

PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
Streptomyces sp. 76 292.86 +- 107.14 2 0 1 1 0.04 +- 0.05 2 13

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF08386 (1/2) TAP-like protein
PF05532 (1/2) CsbD-like
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family
PF00117 (1/2) Glutamine amidotransferase class-I
PF00069 (1/2) Protein kinase domain
Streptomyces sp. NRRL WC-3604 347.82 +- 313.55 3 0 0 0 0.03 +- 0.05 3 1

PF00082 (3/3) Subtilase family
Streptomyces olivochromogenes 67.60 +- 36.23 2 0 1 0 0.09 +- 0.12 2 23

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13796 (1/2) Putative sensor
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12158 (1/2) Protein of unknown function (DUF3592)
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18)
PF01874 (1/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00975 (1/2) Thioesterase domain
PF00877 (1/2) NlpC/P60 family
PF00775 (1/2) Dioxygenase
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
Streptomyces neyagawaensis 143.27 +- 0.00 1 0 0 0 0.06 +- 0.03 1 5

PF04143 (1/1) Sulphur transport
PF03466 (1/1) LysR substrate binding domain
PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/1) CoA-transferase family III
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces sp. st140 624.12 +- 155.88 2 0 2 1 0.06 +- 0.07 2 37

PF00005 (2/2) ABC transporter
TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04978 (1/2) Protein of unknown function (DUF664)
PF04314 (1/2) Copper chaperone PCu(A)C
PF03412 (1/2) Peptidase C39 family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
Streptomyces californicus 148.21 +- 103.34 2 0 0 0 0.04 +- 0.04 2 14

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07690 (1/2) Major Facilitator Superfamily
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. gb14 678.68 +- 350.25 3 0 2 2 0.02 +- 0.01 3 3

PF00005 (3/3) ABC transporter
PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
Streptomyces sp. sk226 53.75 +- 0.00 1 0 1 0 0.09 +- 0.10 1 5

PF03551 (1/1) Transcriptional regulator PadR-like family
PF00975 (1/1) Thioesterase domain
PF00501 (1/1) AMP-binding enzyme
PF00248 (1/1) Aldo/keto reductase family
PF00067 (1/1) Cytochrome P450
Streptomyces murinus 265.59 +- 0.00 1 0 0 0 0.04 +- 0.07 1 14

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (1/1) GYF domain 2
PF13421 (1/1) SPFH domain-Band 7 family
PF08281 (1/1) Sigma-70, region 4
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03824 (1/1) High-affinity nickel-transport protein
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
Streptomyces albidoflavus 197.15 +- 0.00 1 0 1 0 0.09 +- 0.10 1 24

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces rimosus subsp. rimosus 91.45 +- 44.83 4 0 1 1 0.05 +- 0.05 4

No common domains found
Streptomyces sp. CNS654 1235.00 +- 585.00 2 0 2 2 0.01 +- 0.01 2 11

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
Streptomyces novaecaesareae 405.43 +- 368.57 2 0 0 1 0.03 +- 0.03 2 9

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08007 (1/2) Cupin superfamily protein
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (1/2) Radical SAM superfamily
PF01061 (1/2) ABC-2 type transporter
PF00717 (1/2) Peptidase S24-like
PF00248 (1/2) Aldo/keto reductase family
PF00005 (1/2) ABC transporter
Streptomyces sp. V2 74.29 +- 0.00 1 0 0 0 0.04 +- 0.04 1 5

PF13602 (1/1) Zinc-binding dehydrogenase
PF13564 (1/1) DoxX-like family
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00296 (1/1) Luciferase-like monooxygenase
PF00106 (1/1) short chain dehydrogenase
Streptomyces sp. f51 442.29 +- 0.00 1 0 1 1 0.01 +- 0.00 1 7

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces sp. JHA19 236.60 +- 75.67 5 0 0 0 0.07 +- 0.06 5

No common domains found
Streptomyces resistomycificus 701.91 +- 588.09 2 0 0 0 0.04 +- 0.04 2 21

TIGR03567 (1/2) FMN reductase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain
PF14559 (1/2) Tetratricopeptide repeat
PF13535 (1/2) ATP-grasp domain
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (1/2) Tetratricopeptide repeat
PF13424 (1/2) Tetratricopeptide repeat
PF13378 (1/2) Enolase C-terminal domain-like
PF07690 (1/2) Major Facilitator Superfamily
PF04203 (1/2) Sortase domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01613 (1/2) Flavin reductase like domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00326 (1/2) Prolyl oligopeptidase family
PF00294 (1/2) pfkB family carbohydrate kinase
Streptomyces nigra 332.09 +- 206.54 3 0 0 0 0.02 +- 0.03 3

No common domains found
Streptomyces hygroscopicus subsp. limoneus 1040.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

PF08386 (1/1) TAP-like protein
PF07702 (1/1) UTRA domain
PF01380 (1/1) SIS domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces globisporus C-1027 271.28 +- 128.05 3 0 1 1 0.06 +- 0.04 3 1

PF00005 (2/3) ABC transporter
Streptomyces phaeoluteigriseus 260.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF03358 (1/1) NADPH-dependent FMN reductase
PF01425 (1/1) Amidase
Streptomyces sp. CB01883 101.36 +- 27.64 2 0 0 0 0.02 +- 0.03 2 6

PF12802 (1/2) MarR family
PF07681 (1/2) DoxX
PF05977 (1/2) Transmembrane secretion effector
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00583 (1/2) Acetyltransferase (GNAT) family
Streptomyces diastaticus subsp. ardesiacus 129.00 +- 0.00 1 0 1 0 0.04 +- 0.02 1 10

TIGR03301 (1/1) 2-aminoethylphosphonate aminotransferase
TIGR03297 (1/1) phosphonopyruvate decarboxylase
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13454 (1/1) FAD-NAD(P)-binding
PF07690 (1/1) Major Facilitator Superfamily
PF04116 (1/1) Fatty acid hydroxylase superfamily
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00266 (1/1) Aminotransferase class-V
Streptomyces agglomeratus 2824.17 +- 144.94 2 0 2 1 0.01 +- 0.01 2 41

PF00005 (2/2) ABC transporter
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13458 (1/2) Periplasmic binding protein
PF12730 (1/2) ABC-2 family transporter protein
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00384 (1/2) Molybdopterin oxidoreductase
PF00296 (1/2) Luciferase-like monooxygenase
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00069 (1/2) Protein kinase domain
Streptomyces griseolus 194.57 +- 20.42 2 0 0 1 0.04 +- 0.02 2 12

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces exfoliatus DSM 41693 225.44 +- 109.76 3 0 0 0 0.01 +- 0.01 3 1

PF00884 (2/3) Sulfatase
Streptomyces sp. Root55 442.00 +- 0.00 1 0 1 0 0.04 +- 0.05 1 23

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces hygroscopicus subsp. hygroscopicus 251.73 +- 153.90 4 0 1 0 0.03 +- 0.05 4 2

PF07690 (2/4) Major Facilitator Superfamily
PF01425 (2/4) Amidase
Streptomyces sp. b84 193.20 +- 145.93 2 0 1 0 0.04 +- 0.01 2 19

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/2) Amidohydrolase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01872 (1/2) RibD C-terminal domain
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces sp. AA4 409.10 +- 410.25 7 0 3 1 0.06 +- 0.14 7

No common domains found
Streptomyces sp. SceaMP-e96 229.41 +- 160.59 2 0 2 0 0.02 +- 0.03 2 7

PF07883 (1/2) Cupin domain
PF01872 (1/2) RibD C-terminal domain
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01609 (1/2) Transposase DDE domain
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/2) Acetyltransferase (GNAT) family
Streptomyces phaeochromogenes 148.14 +- 106.21 2 0 0 0 0.04 +- 0.04 2 14

TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF13407 (1/2) Periplasmic binding protein domain
PF07971 (1/2) Glycosyl hydrolase family 92
PF07969 (1/2) Amidohydrolase family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (1/2) HAMP domain
PF00553 (1/2) Cellulose binding domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. cf386 435.05 +- 416.85 5 0 2 0 0.04 +- 0.06 5

No common domains found
Streptomyces albidoflavus 540.57 +- 0.00 1 0 1 0 0.07 +- 0.06 1 28

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces diastatochromogenes 256.59 +- 82.97 4 0 2 0 0.04 +- 0.16 4

No common domains found
Streptomyces sp. CNT302 5460.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 9

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces venezuelae 187.39 +- 133.37 4 0 2 2 0.02 +- 0.01 4

No common domains found
Streptomyces sp. DI166 737.77 +- 250.44 3 0 3 3 0.02 +- 0.03 3 1

PF04055 (2/3) Radical SAM superfamily
Streptomyces sp. CB02120-2 453.12 +- 406.37 5 0 1 1 0.03 +- 0.05 5

No common domains found
Streptomyces sp. NRRL S-244 327.88 +- 155.87 2 0 1 1 0.02 +- 0.02 2 16

TIGR00928 (1/2) adenylosuccinate lyase
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13454 (1/2) FAD-NAD(P)-binding
PF10397 (1/2) Adenylosuccinate lyase C-terminus
PF08386 (1/2) TAP-like protein
PF07969 (1/2) Amidohydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (1/2) Bacterial transcriptional activator domain
PF01425 (1/2) Amidase
PF00931 (1/2) NB-ARC domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain
Streptomyces sp. NRRL F-3307 309.60 +- 0.00 1 0 0 0 0.01 +- 0.00 1 4

PF06628 (1/1) Catalase-related immune-responsive
PF01475 (1/1) Ferric uptake regulator family
PF00248 (1/1) Aldo/keto reductase family
PF00199 (1/1) Catalase
Streptomyces sp. NRRL S-146 57.33 +- 0.00 1 0 0 0 0.07 +- 0.03 1 6

PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF13649 (1/1) Methyltransferase domain
PF13535 (1/1) ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF01794 (1/1) Ferric reductase like transmembrane component
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme
Streptomyces sp. 351MFTsu5.1 258.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 9

TIGR04276 (1/1) FxsC C-terminal domain
TIGR04269 (1/1) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (1/1) HEXXH motif domain
PF13676 (1/1) TIR domain
PF13424 (1/1) Tetratricopeptide repeat
PF13374 (1/1) Tetratricopeptide repeat
PF04055 (1/1) Radical SAM superfamily
PF01656 (1/1) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (1/1) NB-ARC domain
Streptomyces sp. 2323.1 448.85 +- 500.64 7 0 2 1 0.02 +- 0.04 7 1

PF07690 (5/7) Major Facilitator Superfamily
Streptomyces sp. e14 388.54 +- 336.20 4 0 1 0 0.02 +- 0.03 4

No common domains found
Streptomyces albidoflavus 114.67 +- 57.33 2 0 1 0 0.06 +- 0.03 2 25

TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
PF18130 (1/2) ATP-grasp N-terminal domain
PF17908 (1/2) APAF-1 helical domain
PF13640 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13586 (1/2) Transposase DDE domain
PF13535 (1/2) ATP-grasp domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12770 (1/2) CHAT domain
PF07993 (1/2) Male sterility protein
PF07510 (1/2) Protein of unknown function (DUF1524)
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04555 (1/2) Restriction endonuclease XhoI
PF03235 (1/2) Protein of unknown function DUF262
PF01937 (1/2) Protein of unknown function DUF89
PF01609 (1/2) Transposase DDE domain
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00931 (1/2) NB-ARC domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00400 (1/2) WD domain, G-beta repeat
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. PTY087I2 435.83 +- 549.81 3 0 2 2 0.04 +- 0.09 3

No common domains found
Streptomyces sp. TSRI0107 71.89 +- 0.00 1 0 0 0 0.08 +- 0.13 1 11

PF13672 (1/1) Protein phosphatase 2C
PF13519 (1/1) von Willebrand factor type A domain
PF13353 (1/1) 4Fe-4S single cluster domain
PF13309 (1/1) HTH domain
PF12770 (1/1) CHAT domain
PF08808 (1/1) RES domain
PF08348 (1/1) YheO-like PAS domain
PF07724 (1/1) AAA domain (Cdc48 subfamily)
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme
PF00069 (1/1) Protein kinase domain
PF00012 (1/1) Hsp70 protein
Streptomyces albulus ZPM 515.55 +- 675.40 7 0 3 1 0.02 +- 0.03 7

No common domains found
Streptomyces sp. alain-838 299.00 +- 0.00 1 0 0 0 0.03 +- 0.14 1 14

TIGR01554 (1/1) phage major capsid protein, HK97 family
TIGR01543 (1/1) phage prohead protease, HK97 family
TIGR01537 (1/1) phage portal protein, HK97 family
TIGR00621 (1/1) single-stranded DNA-binding protein
PF14594 (1/1) Siphovirus ReqiPepy6 Gp37-like protein
PF12708 (1/1) Pectate lyase superfamily protein
PF12307 (1/1) Protein of unknown function (DUF3631)
PF05709 (1/1) Phage tail protein
PF05065 (1/1) Phage capsid family
PF04860 (1/1) Phage portal protein
PF04586 (1/1) Caudovirus prohead serine protease
PF01844 (1/1) HNH endonuclease
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00436 (1/1) Single-strand binding protein family
Streptomyces dengpaensis 156.24 +- 122.33 2 0 0 0 0.05 +- 0.07 2 11

TIGR00561 (1/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12769 (1/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (1/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (1/2) NAD(P) transhydrogenase beta subunit
PF02225 (1/2) PA domain
PF01978 (1/2) Sugar-specific transcriptional regulator TrmB
PF01262 (1/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
Streptomyces sp. DvalAA-83 667.87 +- 141.02 2 0 2 0 0.01 +- 0.01 2 24

TIGR01891 (1/2) amidohydrolase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (1/2) Zinc-binding dehydrogenase
Streptomyces sp. RP5T 326.29 +- 189.71 2 0 0 0 0.03 +- 0.04 2 17

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF14329 (1/2) Domain of unknown function (DUF4386)
PF09339 (1/2) IclR helix-turn-helix domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02866 (1/2) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02452 (1/2) PemK-like, MazF-like toxin of type II toxin-antitoxin system
PF01614 (1/2) Bacterial transcriptional regulator
PF01476 (1/2) LysM domain
PF01425 (1/2) Amidase
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00561 (1/2) alpha/beta hydrolase fold
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00056 (1/2) lactate/malate dehydrogenase, NAD binding domain
Streptomyces globisporus subsp. globisporus 547.05 +- 848.21 5 0 0 0 0.04 +- 0.09 5

No common domains found
Streptomyces mutomycini 124.55 +- 0.00 1 0 0 1 0.03 +- 0.04 1 7

PF13581 (1/1) Histidine kinase-like ATPase domain
PF13191 (1/1) AAA ATPase domain
PF09346 (1/1) SMI1 / KNR4 family (SUKH-1)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF00561 (1/1) alpha/beta hydrolase fold
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces roseochromogenus subsp. oscitans DS 12.976 175.91 +- 0.00 1 0 0 0 0.02 +- 0.02 1 4

PF13377 (1/1) Periplasmic binding protein-like domain
PF08007 (1/1) Cupin superfamily protein
PF02435 (1/1) Levansucrase/Invertase
PF00356 (1/1) Bacterial regulatory proteins, lacI family
Streptomyces malaysiensis 274.03 +- 287.20 5 0 1 1 0.04 +- 0.04 5

No common domains found
Streptomyces sp. TOR3209 130.00 +- 0.00 1 0 0 0 0.04 +- 0.01 1 6

TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13460 (1/1) NAD(P)H-binding
PF07690 (1/1) Major Facilitator Superfamily
PF01814 (1/1) Hemerythrin HHE cation binding domain
PF01494 (1/1) FAD binding domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces sp. SS07 421.38 +- 450.74 4 0 1 1 0.03 +- 0.04 4 1

PF00005 (2/4) ABC transporter
Streptomyces sp. NRRL S-1448 207.58 +- 38.70 3 0 1 0 0.03 +- 0.05 3

No common domains found
Streptomyces stelliscabiei 602.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF17900 (1/1) Peptidase M1 N-terminal domain
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (1/1) DJ-1/PfpI family
PF01433 (1/1) Peptidase family M1 domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00082 (1/1) Subtilase family
Streptomyces radiopugnans 129.13 +- 42.47 2 0 1 0 0.05 +- 0.02 2 19

TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
TIGR00345 (1/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (1/2) 5TM C-terminal transporter carbon starvation CstA
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF02812 (1/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF02554 (1/2) Carbon starvation protein CstA
PF02374 (1/2) Anion-transporting ATPase
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region
PF00696 (1/2) Amino acid kinase family
PF00682 (1/2) HMGL-like
PF00501 (1/2) AMP-binding enzyme
PF00326 (1/2) Prolyl oligopeptidase family
PF00208 (1/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I
Streptomyces hokutonensis 629.20 +- 0.00 1 0 0 0 0.02 +- 0.01 1 10

TIGR02276 (1/1) 40-residue YVTN family beta-propeller repeat
PF13759 (1/1) Putative 2OG-Fe(II) oxygenase
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (1/1) Major Facilitator Superfamily
PF06224 (1/1) Winged helix DNA-binding domain
PF02239 (1/1) Cytochrome D1 heme domain
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces purpeochromogenes 340.92 +- 81.57 2 0 1 0 0.05 +- 0.16 2 35

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF13796 (1/2) Putative sensor
PF13578 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF08659 (1/2) KR domain
PF07730 (1/2) Histidine kinase
PF07179 (1/2) SseB protein N-terminal domain
PF06259 (1/2) Alpha/beta hydrolase
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF03621 (1/2) MbtH-like protein
PF02687 (1/2) FtsX-like permease family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01757 (1/2) Acyltransferase family
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces sp. JS01 930.68 +- 1002.30 3 0 1 1 0.02 +- 0.01 3 1

PF00005 (2/3) ABC transporter
Streptomyces lavenduligriseus 355.33 +- 150.61 3 0 1 0 0.02 +- 0.05 3 4

PF07291 (2/3) Methylamine utilisation protein MauE
PF00717 (2/3) Peptidase S24-like
PF00578 (2/3) AhpC/TSA family
PF00005 (2/3) ABC transporter
Streptomyces venezuelae 187.39 +- 133.37 4 0 2 2 0.02 +- 0.01 4

No common domains found
Streptomyces sp. TSRI0395 223.60 +- 34.40 2 0 1 0 0.04 +- 0.07 2 14

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (1/2) SnoaL-like domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/2) SseB protein N-terminal domain
PF07045 (1/2) Domain of unknown function (DUF1330)
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01738 (1/2) Dienelactone hydrolase family
PF00664 (1/2) ABC transporter transmembrane region
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter
Streptomyces pactum 502.43 +- 0.00 1 0 1 0 0.03 +- 0.03 1 18

PF16197 (1/1) Ketoacyl-synthetase C-terminal extension
PF14765 (1/1) Polyketide synthase dehydratase
PF13191 (1/1) AAA ATPase domain
PF08659 (1/1) KR domain
PF04820 (1/1) Tryptophan halogenase
PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (1/1) Bacterial transcriptional activator domain
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01613 (1/1) Flavin reductase like domain
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00698 (1/1) Acyl transferase domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces huasconensis 1560.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter
Streptomyces sp. Ncost-T6T-1 1238.40 +- 0.00 1 0 1 1 0.01 +- 0.01 1 8

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces sp. 2112.2 260.45 +- 175.21 6 0 3 1 0.04 +- 0.14 6 1

PF07690 (4/6) Major Facilitator Superfamily
Streptomyces sp. Amel2xC10 672.38 +- 761.59 3 0 1 2 0.03 +- 0.08 3

No common domains found
Streptomyces griseofuscus 199.99 +- 154.70 4 0 1 0 0.04 +- 0.07 4 1

PF07690 (3/4) Major Facilitator Superfamily
Streptomyces sp. NRRL F-6492 282.30 +- 219.37 2 0 0 0 0.04 +- 0.08 2 13

PF18556 (1/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (1/2) MftR C-terminal domain
PF13460 (1/2) NAD(P)H-binding
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01418 (1/2) Helix-turn-helix domain, rpiR family
PF01380 (1/2) SIS domain
PF01266 (1/2) FAD dependent oxidoreductase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (1/2) NUDIX domain
Streptomyces sp. f150 197.77 +- 128.18 3 0 1 0 0.07 +- 0.13 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. NRRL F-2747 387.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 5

PF17874 (1/1) MalT-like TPR region
PF12770 (1/1) CHAT domain
PF04030 (1/1) D-arabinono-1,4-lactone oxidase
PF01565 (1/1) FAD binding domain
PF00248 (1/1) Aldo/keto reductase family
Streptomyces sp. Go-475 126.33 +- 9.33 2 0 0 0 0.03 +- 0.01 2 15

PF16349 (1/2) Domain of unknown function (DUF4978)
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14100 (1/2) Methane oxygenase PmoA
PF13377 (1/2) Periplasmic binding protein-like domain
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF12697 (1/2) Alpha/beta hydrolase family
PF11706 (1/2) CGNR zinc finger
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF02894 (1/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02525 (1/2) Flavodoxin-like fold
PF01614 (1/2) Bacterial transcriptional regulator
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00356 (1/2) Bacterial regulatory proteins, lacI family
Streptomyces sp. NRRL B-5680 1225.38 +- 1932.98 5 0 2 2 0.03 +- 0.05 5

No common domains found
Streptomyces sp. or20 73.71 +- 0.00 1 0 1 0 0.03 +- 0.02 1 3

TIGR03083 (1/1) uncharacterized Actinobacterial protein TIGR03083
PF11716 (1/1) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02627 (1/1) Carboxymuconolactone decarboxylase family
Streptomyces sp. Ncost-T10-10d 199.03 +- 84.51 6 0 1 1 0.04 +- 0.05 6

No common domains found
Streptomyces sp. NBRC 110465 260.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF09995 (1/1) Uncharacterized protein conserved in bacteria (DUF2236)
PF00246 (1/1) Zinc carboxypeptidase
Streptomyces viridosporus ATCC 14672 110.12 +- 0.00 1 0 0 0 0.05 +- 0.09 1 8

PF12450 (1/1) von Willebrand factor
PF12034 (1/1) Domain of unknown function (DUF3520)
PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00501 (1/1) AMP-binding enzyme
PF00092 (1/1) von Willebrand factor type A domain
PF00005 (1/1) ABC transporter
Streptomyces koyangensis 177.38 +- 145.12 2 0 0 0 0.03 +- 0.02 2 10

PF00561 (2/2) alpha/beta hydrolase fold
PF12697 (1/2) Alpha/beta hydrolase family
PF11723 (1/2) Homotrimeric ring hydroxylase
PF08386 (1/2) TAP-like protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces oceani 103.20 +- 0.00 1 0 1 0 0.02 +- 0.00 1 2

PF13302 (1/1) Acetyltransferase (GNAT) domain
PF00156 (1/1) Phosphoribosyl transferase domain
Streptomyces davaonensis JCM 4913 1012.15 +- 19.85 2 0 1 1 0.01 +- 0.00 2 13

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR03296 (1/2) M6 family metalloprotease domain
PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08241 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF01980 (1/2) tRNA-methyltransferase O
PF01614 (1/2) Bacterial transcriptional regulator
PF01494 (1/2) FAD binding domain
PF01471 (1/2) Putative peptidoglycan binding domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
Streptomyces yanglinensis 274.12 +- 112.88 2 0 2 2 0.02 +- 0.03 2 17

TIGR03558 (1/2) luciferase family oxidoreductase, group 1
TIGR02822 (1/2) zinc-binding alcohol dehydrogenase family protein
PF14518 (1/2) Iron-containing redox enzyme
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05630 (1/2) Necrosis inducing protein (NPP1)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04055 (1/2) Radical SAM superfamily
PF03704 (1/2) Bacterial transcriptional activator domain
PF00931 (1/2) NB-ARC domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00296 (1/2) Luciferase-like monooxygenase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain
Streptomyces sp. 2224.1 118.86 +- 0.00 1 0 0 0 0.03 +- 0.03 1 6

PF12833 (1/1) Helix-turn-helix domain
PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00578 (1/1) AhpC/TSA family
PF00005 (1/1) ABC transporter
Streptomyces yunnanensis 1227.17 +- 1178.68 3 0 2 0 0.01 +- 0.01 3 2

PF07690 (2/3) Major Facilitator Superfamily
PF00196 (2/3) Bacterial regulatory proteins, luxR family
Streptomyces sp. WAC05374 403.88 +- 0.00 1 0 1 0 0.04 +- 0.03 1 25

TIGR01733 (1/1) amino acid adenylation domain
PF16653 (1/1) Saccharopine dehydrogenase C-terminal domain
PF14518 (1/1) Iron-containing redox enzyme
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF05222 (1/1) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (1/1) Saccharopine dehydrogenase NADP binding domain
PF03417 (1/1) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01266 (1/1) FAD dependent oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (1/1) Cytochrome P450
Streptomyces sp. CNY228 241.21 +- 170.50 3 0 1 1 0.07 +- 0.12 3

No common domains found
Streptomyces albidoflavus 22.94 +- 0.00 1 0 0 0 0.09 +- 0.06 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces sp. NRRL WC-3744 169.72 +- 120.26 3 0 1 1 0.08 +- 0.14 3

No common domains found
Streptomyces sp. WM6373 618.44 +- 542.56 2 0 0 1 0.03 +- 0.05 2 29

TIGR02493 (1/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (1/2) pyruvate, phosphate dikinase
TIGR01426 (1/2) glycosyltransferase, MGT family
TIGR01255 (1/2) formate acetyltransferase
PF17914 (1/2) HopA1 effector protein family
PF14325 (1/2) Domain of unknown function (DUF4383)
PF13692 (1/2) Glycosyl transferases group 1
PF13601 (1/2) Winged helix DNA-binding domain
PF13411 (1/2) MerR HTH family regulatory protein
PF12698 (1/2) ABC-2 family transporter protein
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02901 (1/2) Pyruvate formate lyase-like
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (1/2) B12 binding domain
PF02441 (1/2) Flavoprotein
PF01636 (1/2) Phosphotransferase enzyme family
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (1/2) Glycine radical
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00582 (1/2) Universal stress protein family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces sp. ICBB 8177 119.08 +- 0.00 1 0 0 0 0.02 +- 0.02 1 3

PF13560 (1/1) Helix-turn-helix domain
PF00891 (1/1) O-methyltransferase domain
PF00239 (1/1) Resolvase, N terminal domain
Streptomyces albus subsp. albus 260.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 1

PF04655 (1/1) Aminoglycoside/hydroxyurea antibiotic resistance kinase
Streptomyces alni 1316.55 +- 1130.39 4 0 4 2 0.01 +- 0.01 4 3

PF13575 (2/4) Domain of unknown function (DUF4135)
PF00664 (2/4) ABC transporter transmembrane region
PF00005 (2/4) ABC transporter
Streptomyces scabiei 100.29 +- 48.29 2 0 0 0 0.03 +- 0.03 2 9

PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF16757 (1/2) Alpha-L-fucosidase C-terminal domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13460 (1/2) NAD(P)H-binding
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01120 (1/2) Alpha-L-fucosidase
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00561 (1/2) alpha/beta hydrolase fold
Streptomyces sp. FXJ7.023 252.97 +- 0.00 1 0 1 1 0.09 +- 0.25 1 11

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13601 (1/1) Winged helix DNA-binding domain
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04820 (1/1) Tryptophan halogenase
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. A244 33.33 +- 0.00 1 0 0 0 0.06 +- 0.09 1 6

PF17996 (1/1) Carbohydrate esterase 2 N-terminal
PF17829 (1/1) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (1/1) Glycosyl hydrolase family 115
PF13472 (1/1) GDSL-like Lipase/Acylhydrolase family
PF13191 (1/1) AAA ATPase domain
PF00067 (1/1) Cytochrome P450
Streptomyces hyaluromycini 1093.43 +- 1235.07 3 0 1 0 0.01 +- 0.02 3

No common domains found
Streptomyces sp. 769 159.69 +- 145.38 8 0 3 0 0.05 +- 0.08 8

No common domains found
Streptomyces sp. WAC07061 412.80 +- 0.00 1 0 1 0 0.01 +- 0.00 1 7

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13546 (1/1) DDE superfamily endonuclease
PF05193 (1/1) Peptidase M16 inactive domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00005 (1/1) ABC transporter
Streptomyces harbinensis 78.93 +- 17.82 2 0 1 0 0.06 +- 0.06 2 20

TIGR03557 (1/2) F420-dependent oxidoreductase, G6PDH family
TIGR01733 (1/2) amino acid adenylation domain
TIGR01136 (1/2) cysteine synthase
PF14027 (1/2) Questin oxidase-like
PF12833 (1/2) Helix-turn-helix domain
PF11814 (1/2) Peptidase_C39 like family
PF02311 (1/2) AraC-like ligand binding domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00975 (1/2) Thioesterase domain
PF00892 (1/2) EamA-like transporter family
PF00550 (1/2) Phosphopantetheine attachment site
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00501 (1/2) AMP-binding enzyme
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
Streptomyces sp. NRRL B-24051 321.58 +- 61.58 2 0 1 1 0.02 +- 0.01 2 17

TIGR00229 (1/2) PAS domain S-box protein
PF08448 (1/2) PAS fold
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04055 (1/2) Radical SAM superfamily
PF03466 (1/2) LysR substrate binding domain
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02310 (1/2) B12 binding domain
PF01590 (1/2) GAF domain
PF01494 (1/2) FAD binding domain
PF00733 (1/2) Asparagine synthase
PF00501 (1/2) AMP-binding enzyme
PF00455 (1/2) DeoR C terminal sensor domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00069 (1/2) Protein kinase domain
Streptomyces halstedii 109.97 +- 12.47 2 0 0 1 0.06 +- 0.04 2 12

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces alfalfae 422.83 +- 255.32 4 0 2 2 0.03 +- 0.11 4 4

PF07690 (3/4) Major Facilitator Superfamily
PF04055 (2/4) Radical SAM superfamily
PF02310 (2/4) B12 binding domain
PF00326 (2/4) Prolyl oligopeptidase family
Streptomyces orinoci 235.10 +- 135.05 3 0 0 1 0.03 +- 0.09 3

No common domains found
Streptomyces iranensis 440.14 +- 205.13 5 0 1 0 0.04 +- 0.09 5

No common domains found
Streptomyces aureocirculatus 348.73 +- 213.99 3 0 0 0 0.05 +- 0.12 3

No common domains found
Streptomyces acidiscabies 84-104 346.16 +- 55.91 2 0 1 0 0.06 +- 0.22 2 26

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01746 (1/2) thioester reductase domain
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10901 (1/2) Protein of unknown function (DUF2690)
PF08443 (1/2) RimK-like ATP-grasp domain
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter
Streptomyces niger 211.04 +- 104.96 6 0 0 2 0.06 +- 0.16 6

No common domains found
Streptomyces sp. AC1-42W 732.61 +- 344.29 5 0 4 3 0.02 +- 0.02 5 1

PF07690 (4/5) Major Facilitator Superfamily
Streptomyces varsoviensis 1058.57 +- 583.30 4 0 4 2 0.01 +- 0.00 4 2

PF00550 (2/4) Phosphopantetheine attachment site
PF00005 (2/4) ABC transporter
Streptomyces venezuelae ATCC 10712 269.79 +- 233.27 6 0 2 2 0.03 +- 0.11 6

No common domains found
Streptomyces sp. Mg1 288.99 +- 200.93 2 0 1 0 0.05 +- 0.07 2 32

PF07690 (2/2) Major Facilitator Superfamily
TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (1/2) aminodeoxychorismate synthase, component I
PF13622 (1/2) Thioesterase-like superfamily
PF13621 (1/2) Cupin-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12146 (1/2) Serine aminopeptidase, S33
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08031 (1/2) Berberine and berberine like
PF07836 (1/2) DmpG-like communication domain
PF04715 (1/2) Anthranilate synthase component I, N terminal region
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01474 (1/2) Class-II DAHP synthetase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01063 (1/2) Amino-transferase class IV
PF00682 (1/2) HMGL-like
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00425 (1/2) chorismate binding enzyme
PF00301 (1/2) Rubredoxin
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I
PF00067 (1/2) Cytochrome P450
Streptomyces chartreusis 218.08 +- 48.86 3 0 2 2 0.04 +- 0.13 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. LaPpAH-165 645.36 +- 394.64 2 0 1 1 0.03 +- 0.03 2 19

TIGR03396 (1/2) phospholipase C, phosphocholine-specific
TIGR01258 (1/2) phosphoglycerate mutase 1 family
TIGR01060 (1/2) phosphopyruvate hydratase
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05506 (1/2) Domain of unknown function (DUF756)
PF04185 (1/2) Phosphoesterase family
PF04055 (1/2) Radical SAM superfamily
PF03965 (1/2) Penicillinase repressor
PF03952 (1/2) Enolase, N-terminal domain
PF03453 (1/2) MoeA N-terminal region (domain I and II)
PF02441 (1/2) Flavoprotein
PF01712 (1/2) Deoxynucleoside kinase
PF01435 (1/2) Peptidase family M48
PF00994 (1/2) Probable molybdopterin binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00293 (1/2) NUDIX domain
PF00113 (1/2) Enolase, C-terminal TIM barrel domain
Streptomyces sp. S1 341.57 +- 113.49 3 0 1 0 0.02 +- 0.05 3

No common domains found
Streptomyces sp. Ru62 559.00 +- 481.00 2 0 0 0 0.02 +- 0.03 2 12

PF07690 (2/2) Major Facilitator Superfamily
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13460 (1/2) NAD(P)H-binding
PF13393 (1/2) Histidyl-tRNA synthetase
PF07859 (1/2) alpha/beta hydrolase fold
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00152 (1/2) tRNA synthetases class II (D, K and N)
PF00067 (1/2) Cytochrome P450
Streptomyces rimosus subsp. rimosus 71.86 +- 41.63 3 0 2 1 0.08 +- 0.08 3

No common domains found
Streptomyces albidoflavus 44.48 +- 0.00 1 0 0 0 0.04 +- 0.03 1 5

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00931 (1/1) NB-ARC domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces avermitilis MA-4680 = NBRC 14893 191.74 +- 10.48 2 0 1 0 0.07 +- 0.10 2 17

PF07690 (2/2) Major Facilitator Superfamily
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (1/2) Domain of unknown function (DUF4331)
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02882 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00925 (1/2) GTP cyclohydrolase II
PF00763 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00348 (1/2) Polyprenyl synthetase
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
PF00082 (1/2) Subtilase family
Streptomyces sp. WMMB 714 117.96 +- 12.04 2 0 0 0 0.06 +- 0.09 2 21

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01891 (1/2) amidohydrolase
PF13738 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF13091 (1/2) PLD-like domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (1/2) NMT1/THI5 like
PF06267 (1/2) Family of unknown function (DUF1028)
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF03466 (1/2) LysR substrate binding domain
PF02386 (1/2) Cation transport protein
PF02254 (1/2) TrkA-N domain
PF02080 (1/2) TrkA-C domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01042 (1/2) Endoribonuclease L-PSP
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00296 (1/2) Luciferase-like monooxygenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (1/2) Sugar (and other) transporter
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. rimosus 47.24 +- 3.02 2 0 1 1 0.09 +- 0.08 2 12

PF14158 (1/2) YndJ-like protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13492 (1/2) GAF domain
PF13471 (1/2) Transglutaminase-like superfamily
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00733 (1/2) Asparagine synthase
PF00149 (1/2) Calcineurin-like phosphoesterase
Streptomyces natalensis ATCC 27448 1350.92 +- 1370.79 3 0 0 0 0.01 +- 0.00 3

No common domains found
Streptomyces sp. XY66 1935.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces filamentosus NRRL 15998 668.57 +- 0.00 1 0 1 1 0.03 +- 0.01 1 8

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces noursei 460.58 +- 358.07 6 0 3 0 0.03 +- 0.04 6

No common domains found
Streptomyces cattleya NRRL 8057 = DSM 46488 228.93 +- 0.00 1 0 1 0 0.08 +- 0.26 1 18

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00976 (1/1) hydrolase CocE/NonD family protein
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16911 (1/1) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
PF13581 (1/1) Histidine kinase-like ATPase domain
PF12911 (1/1) N-terminal TM domain of oligopeptide transport permease C
PF09339 (1/1) IclR helix-turn-helix domain
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (1/1) Major Facilitator Superfamily
PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/1) CoA-transferase family III
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (1/1) Bacterial transcriptional regulator
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces sp. CS159 561.83 +- 388.08 2 0 1 0 0.04 +- 0.12 2 26

PF00682 (2/2) HMGL-like
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00710 (1/2) drug resistance transporter, Bcr/CflA subfamily
TIGR00171 (1/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (1/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (1/2) 3-isopropylmalate dehydrogenase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF11806 (1/2) Domain of unknown function (DUF3327)
PF08242 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF03737 (1/2) Aldolase/RraA
PF03621 (1/2) MbtH-like protein
PF03466 (1/2) LysR substrate binding domain
PF01361 (1/2) Tautomerase enzyme
PF00994 (1/2) Probable molybdopterin binding domain
PF00756 (1/2) Putative esterase
PF00694 (1/2) Aconitase C-terminal domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00330 (1/2) Aconitase family (aconitate hydratase)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces scabiei 423.30 +- 226.81 3 0 2 0 0.02 +- 0.02 3 1

PF00561 (2/3) alpha/beta hydrolase fold
Streptomyces shenzhenensis 780.73 +- 530.82 5 0 0 0 0.03 +- 0.10 5 3

PF08402 (3/5) TOBE domain
PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
PF00005 (3/5) ABC transporter
Streptomyces agglomeratus 1197.28 +- 1112.33 2 0 2 0 0.03 +- 0.05 2 48

TIGR02965 (1/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (1/2) xanthine dehydrogenase accessory protein XdhC
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13478 (1/2) XdhC Rossmann domain
PF13458 (1/2) Periplasmic binding protein
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02625 (1/2) XdhC and CoxI family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01070 (1/2) FMN-dependent dehydrogenase
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00756 (1/2) Putative esterase
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00384 (1/2) Molybdopterin oxidoreductase
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter
Streptomyces sp. Tue6028 46.36 +- 0.83 2 0 0 1 0.06 +- 0.11 2 20

TIGR04269 (1/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (1/2) FXSXX-COOH protein
TIGR04267 (1/2) HEXXH motif domain
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (1/2) Bacterial Ig domain
PF14864 (1/2) Alkyl sulfatase C-terminal
PF14863 (1/2) Alkyl sulfatase dimerisation
PF13676 (1/2) TIR domain
PF13424 (1/2) Tetratricopeptide repeat
PF13374 (1/2) Tetratricopeptide repeat
PF13365 (1/2) Trypsin-like peptidase domain
PF12680 (1/2) SnoaL-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04055 (1/2) Radical SAM superfamily
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF01361 (1/2) Tautomerase enzyme
PF00931 (1/2) NB-ARC domain
PF00912 (1/2) Transglycosylase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces sp. CB00455 617.78 +- 387.08 2 0 0 0 0.04 +- 0.03 2 25

TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
PF17874 (1/2) MalT-like TPR region
PF13621 (1/2) Cupin-like domain
PF13560 (1/2) Helix-turn-helix domain
PF13393 (1/2) Histidyl-tRNA synthetase
PF13191 (1/2) AAA ATPase domain
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (1/2) DmpG-like communication domain
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00682 (1/2) HMGL-like
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter
Streptomyces sp. MNU77 212.13 +- 239.29 3 0 2 0 0.04 +- 0.03 3

No common domains found
Streptomyces sp. RTd22 179.24 +- 103.00 4 0 0 1 0.05 +- 0.08 4

No common domains found
Streptomyces qinglanensis 2797.24 +- 0.00 1 0 1 1 0.02 +- 0.01 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter
Streptomyces sp. TP-A0874 855.53 +- 692.47 2 0 0 0 0.07 +- 0.21 2 24

PF13377 (1/2) Periplasmic binding protein-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13183 (1/2) 4Fe-4S dicluster domain
PF12697 (1/2) Alpha/beta hydrolase family
PF09339 (1/2) IclR helix-turn-helix domain
PF07090 (1/2) Putative glutamine amidotransferase
PF04072 (1/2) Leucine carboxyl methyltransferase
PF03069 (1/2) Acetamidase/Formamidase family
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02754 (1/2) Cysteine-rich domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02608 (1/2) ABC transporter substrate-binding protein PnrA-like
PF02515 (1/2) CoA-transferase family III
PF01614 (1/2) Bacterial transcriptional regulator
PF01565 (1/2) FAD binding domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01156 (1/2) Inosine-uridine preferring nucleoside hydrolase
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
Streptomyces albus subsp. albus 43.00 +- 0.00 1 0 0 0 0.07 +- 0.10 1 5

PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
Streptomyces yeochonensis CN732 258.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 6

PF14015 (1/1) Protein of unknown function (DUF4231)
PF08244 (1/1) Glycosyl hydrolases family 32 C terminal
PF04314 (1/1) Copper chaperone PCu(A)C
PF01674 (1/1) Lipase (class 2)
PF01435 (1/1) Peptidase family M48
PF00251 (1/1) Glycosyl hydrolases family 32 N-terminal domain
Streptomyces sp. PalvLS-984 376.34 +- 93.94 2 0 0 0 0.04 +- 0.01 2 28

TIGR03561 (1/2) peroxiredoxin, Ohr subfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/2) IclR helix-turn-helix domain
PF09084 (1/2) NMT1/THI5 like
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF04199 (1/2) Putative cyclase
PF03972 (1/2) MmgE/PrpD family
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (1/2) OsmC-like protein
PF02515 (1/2) CoA-transferase family III
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01979 (1/2) Amidohydrolase family
PF01614 (1/2) Bacterial transcriptional regulator
PF01546 (1/2) Peptidase family M20/M25/M40
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
Streptomyces flavovirens 404.44 +- 0.00 1 0 1 1 0.02 +- 0.01 1 7

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF03466 (1/1) LysR substrate binding domain
PF02310 (1/1) B12 binding domain
PF00733 (1/1) Asparagine synthase
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces sp. NRRL F-2580 2655.62 +- 2375.38 2 0 0 0 0.01 +- 0.01 2 23

PF17914 (1/2) HopA1 effector protein family
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF12698 (1/2) ABC-2 family transporter protein
PF07690 (1/2) Major Facilitator Superfamily
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF05193 (1/2) Peptidase M16 inactive domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02441 (1/2) Flavoprotein
PF02225 (1/2) PA domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Embleya scabrispora DSM 41855 344.33 +- 273.07 3 0 1 0 0.06 +- 0.22 3

No common domains found
Streptomyces sp. NBS 14/10 241.32 +- 123.64 7 0 3 3 0.03 +- 0.06 7

No common domains found
Streptomyces alboflavus 197.29 +- 60.71 2 0 1 0 0.02 +- 0.03 2 15

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
TIGR01733 (1/2) amino acid adenylation domain
TIGR01297 (1/2) cation diffusion facilitator family transporter
PF12680 (1/2) SnoaL-like domain
PF08242 (1/2) Methyltransferase domain
PF07883 (1/2) Cupin domain
PF02031 (1/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (1/2) IstB-like ATP binding protein
PF01545 (1/2) Cation efflux family
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00665 (1/2) Integrase core domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00221 (1/2) Aromatic amino acid lyase
Streptomyces silaceus 50.17 +- 7.17 2 0 1 0 0.05 +- 0.05 2 12

PF17874 (1/2) MalT-like TPR region
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
PF12697 (1/2) Alpha/beta hydrolase family
PF08002 (1/2) Protein of unknown function (DUF1697)
PF07063 (1/2) Domain of unknown function (DUF1338)
PF05922 (1/2) Peptidase inhibitor I9
PF01323 (1/2) DSBA-like thioredoxin domain
PF01266 (1/2) FAD dependent oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family
Streptomyces sp. SirexAA-E 360.86 +- 245.80 2 0 2 0 0.04 +- 0.06 2 24

TIGR01891 (1/2) amidohydrolase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (1/2) Zinc-binding dehydrogenase
Streptomyces sp. CB02366 22.03 +- 0.00 1 0 0 0 0.09 +- 0.19 1 19

TIGR03638 (1/1) CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI
TIGR02548 (1/1) CRISPR type I-E/ECOLI-associated protein CasB/Cse2
TIGR02547 (1/1) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
TIGR01907 (1/1) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
TIGR01873 (1/1) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
TIGR01869 (1/1) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
TIGR01868 (1/1) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
TIGR01596 (1/1) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (1/1) CRISPR-associated helicase Cas3
PF18395 (1/1) Cas3 C-terminal domain
PF18019 (1/1) HD domain
PF09707 (1/1) CRISPR-associated protein (Cas_Cas2CT1978)
PF09704 (1/1) CRISPR-associated protein (Cas_Cas5)
PF09485 (1/1) CRISPR-associated protein Cse2 (CRISPR_cse2)
PF09481 (1/1) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF09344 (1/1) CT1975-like protein
PF08798 (1/1) CRISPR associated protein
PF07876 (1/1) Stress responsive A/B Barrel Domain
PF05685 (1/1) Putative restriction endonuclease
Streptomyces sp. DpondAA-D4 301.05 +- 23.95 2 0 0 1 0.02 +- 0.02 2 12

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces sp. F001 471.39 +- 439.62 3 0 1 0 0.05 +- 0.14 3 1

PF00005 (2/3) ABC transporter
Streptomyces avermitilis MA-4680 = NBRC 14893 304.63 +- 206.48 4 0 2 0 0.03 +- 0.05 4 1

PF07690 (3/4) Major Facilitator Superfamily
Streptomyces sp. NL15-2K 1350.51 +- 1605.33 3 0 2 1 0.02 +- 0.03 3 1

PF00005 (2/3) ABC transporter
Streptomyces galbus 30.35 +- 0.00 1 0 0 0 0.07 +- 0.03 1 1

PF00069 (1/1) Protein kinase domain
Streptomyces sp. Ncost-T6T-1 2080.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces sp. ZL-24 455.00 +- 0.00 1 0 1 0 0.05 +- 0.02 1 18

TIGR00976 (1/1) hydrolase CocE/NonD family protein
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12697 (1/1) Alpha/beta hydrolase family
PF12679 (1/1) ABC-2 family transporter protein
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/1) Amidohydrolase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/1) Coenzyme A transferase
PF00501 (1/1) AMP-binding enzyme
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/1) short chain dehydrogenase
PF00005 (1/1) ABC transporter
Streptomyces sp. SDr-06 207.63 +- 180.71 4 0 3 1 0.04 +- 0.05 4 1

PF00583 (2/4) Acetyltransferase (GNAT) family
Streptomyces sp. MUSC 14 830.34 +- 623.33 3 0 2 2 0.05 +- 0.13 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. HmicA12 156.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 6

PF17103 (1/1) Stealth protein CR4, conserved region 4
PF17102 (1/1) Stealth protein CR3, conserved region 3
PF17101 (1/1) Stealth protein CR1, conserved region 1
PF13091 (1/1) PLD-like domain
PF11380 (1/1) Stealth protein CR2, conserved region 2
PF07859 (1/1) alpha/beta hydrolase fold
Streptomyces atratus 291.95 +- 313.08 5 0 0 0 0.03 +- 0.11 5

No common domains found
Streptomyces sp. C 365.53 +- 162.02 3 0 2 1 0.02 +- 0.02 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. IMTB 1903 37.22 +- 2.82 2 0 0 0 0.07 +- 0.13 2 7

TIGR03707 (1/2) polyphosphate kinase 2
PF12802 (1/2) MarR family
PF11239 (1/2) Protein of unknown function (DUF3040)
PF04231 (1/2) Endonuclease I
PF03976 (1/2) Polyphosphate kinase 2 (PPK2)
PF03301 (1/2) Tryptophan 2,3-dioxygenase
PF01425 (1/2) Amidase
Streptomyces baarnensis 228.40 +- 239.32 5 0 3 2 0.06 +- 0.07 5

No common domains found
Streptomyces sp. ScaeMP-e83 221.11 +- 182.02 2 0 0 0 0.06 +- 0.04 2 23

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16656 (1/2) Purple acid Phosphatase, N-terminal domain
PF13795 (1/2) HupE / UreJ protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF06030 (1/2) Bacterial protein of unknown function (DUF916)
PF04909 (1/2) Amidohydrolase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00149 (1/2) Calcineurin-like phosphoesterase
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces sp. CNQ329 644.20 +- 346.40 3 0 2 0 0.04 +- 0.17 3 2

PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00005 (2/3) ABC transporter
Streptomyces megasporus 423.08 +- 21.75 2 0 1 0 0.02 +- 0.03 2 23

TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF13459 (1/2) 4Fe-4S single cluster domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (1/2) FCD domain
PF07722 (1/2) Peptidase C26
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00067 (1/2) Cytochrome P450
Streptomyces virginiae 258.72 +- 14.97 2 0 1 0 0.06 +- 0.16 2 17

TIGR03797 (1/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (1/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13459 (1/2) 4Fe-4S single cluster domain
PF13437 (1/2) HlyD family secretion protein
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF10589 (1/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/2) TAP-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF05013 (1/2) N-formylglutamate amidohydrolase
PF03640 (1/2) Secreted repeat of unknown function
PF03412 (1/2) Peptidase C39 family
PF03055 (1/2) Retinal pigment epithelial membrane protein
PF01512 (1/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00664 (1/2) ABC transporter transmembrane region
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter
Streptomyces albulus 57.33 +- 0.00 1 0 1 0 0.05 +- 0.07 1 4

PF07690 (1/1) Major Facilitator Superfamily
PF03621 (1/1) MbtH-like protein
PF01019 (1/1) Gamma-glutamyltranspeptidase
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Streptomyces sp. 3214.6 291.86 +- 377.70 5 0 1 1 0.04 +- 0.06 5

No common domains found
Streptomyces albus 62.40 +- 0.00 1 0 0 0 0.05 +- 0.07 1 5

PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
Streptomyces sp. LaPpAH-202 422.68 +- 0.00 1 0 1 1 0.07 +- 0.08 1 12

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/1) AAA ATPase domain
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter
Streptomyces sp. Wb2n-11 263.86 +- 198.86 2 0 0 0 0.04 +- 0.03 2 18

TIGR00843 (1/2) benzoate transporter
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF13535 (1/2) ATP-grasp domain
PF12833 (1/2) Helix-turn-helix domain
PF10994 (1/2) Protein of unknown function (DUF2817)
PF07690 (1/2) Major Facilitator Superfamily
PF03594 (1/2) Benzoate membrane transport protein
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01070 (1/2) FMN-dependent dehydrogenase
PF00696 (1/2) Amino acid kinase family
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II
Streptomyces rimosus subsp. rimosus 112.10 +- 53.96 5 0 2 1 0.04 +- 0.05 5

No common domains found
Streptomyces carpinensis 125.71 +- 40.75 3 0 0 0 0.03 +- 0.04 3

No common domains found
Streptomyces sp. AC1-42T 691.82 +- 241.84 4 0 3 2 0.01 +- 0.01 4 3

PF07690 (3/4) Major Facilitator Superfamily
PF02668 (2/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/4) B12 binding domain
Streptomyces sp. 3212.3 260.00 +- 0.00 1 0 0 0 0.02 +- 0.02 1 3

PF13365 (1/1) Trypsin-like peptidase domain
PF00400 (1/1) WD domain, G-beta repeat
PF00248 (1/1) Aldo/keto reductase family
Streptomyces sp. NRRL S-813 127.31 +- 62.83 3 0 0 0 0.04 +- 0.08 3

No common domains found
Streptomyces bicolor 94.55 +- 0.00 1 0 1 0 0.02 +- 0.01 1 4

PF04073 (1/1) Aminoacyl-tRNA editing domain
PF01116 (1/1) Fructose-bisphosphate aldolase class-II
PF00892 (1/1) EamA-like transporter family
PF00464 (1/1) Serine hydroxymethyltransferase
Streptomyces rimosus subsp. rimosus 44.23 +- 0.00 1 0 1 1 0.07 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. OspMP-M45 157.05 +- 94.21 3 0 1 2 0.04 +- 0.02 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces rubellomurinus 45.27 +- 2.61 3 0 1 0 0.06 +- 0.07 3

No common domains found
Streptomyces niveiscabiei 32.50 +- 0.00 1 0 0 0 0.06 +- 0.05 1 3

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00106 (1/1) short chain dehydrogenase
Streptomyces griseus 558.52 +- 221.48 2 0 1 1 0.03 +- 0.02 2 12

PF00005 (2/2) ABC transporter
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00296 (1/2) Luciferase-like monooxygenase
PF00069 (1/2) Protein kinase domain
Streptomyces niveus NCIMB 11891 1917.50 +- 942.50 2 0 0 1 0.01 +- 0.00 2 22

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF08402 (1/2) TOBE domain
PF08241 (1/2) Methyltransferase domain
PF07993 (1/2) Male sterility protein
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF03176 (1/2) MMPL family
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01575 (1/2) MaoC like domain
PF00962 (1/2) Adenosine/AMP deaminase
PF00881 (1/2) Nitroreductase family
PF00698 (1/2) Acyl transferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter
Streptomyces sp. WAC00288 247.33 +- 247.25 3 0 1 0 0.05 +- 0.16 3

No common domains found
Streptomyces anulatus 582.45 +- 191.55 2 0 1 1 0.01 +- 0.01 2 24

TIGR01558 (1/2) putative phage terminase, small subunit, P27 family
TIGR01554 (1/2) phage major capsid protein, HK97 family
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR01537 (1/2) phage portal protein, HK97 family
PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (1/2) Phage-related minor tail protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF05119 (1/2) Phage terminase, small subunit
PF05065 (1/2) Phage capsid family
PF04860 (1/2) Phage portal protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF04672 (1/2) S-adenosyl methyltransferase
PF04586 (1/2) Caudovirus prohead serine protease
PF04542 (1/2) Sigma-70 region 2
PF03354 (1/2) Phage Terminase
PF01844 (1/2) HNH endonuclease
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (1/2) Collagen triple helix repeat (20 copies)
PF01381 (1/2) Helix-turn-helix
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00271 (1/2) Helicase conserved C-terminal domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces griseus subsp. griseus NBRC 13350 77.40 +- 0.00 1 0 0 0 0.05 +- 0.05 1 5

PF14103 (1/1) Domain of unknown function (DUF4276)
PF13304 (1/1) AAA domain, putative AbiEii toxin, Type IV TA system
PF04101 (1/1) Glycosyltransferase family 28 C-terminal domain
PF03033 (1/1) Glycosyltransferase family 28 N-terminal domain
PF02463 (1/1) RecF/RecN/SMC N terminal domain
Streptomyces atratus 308.79 +- 212.61 4 0 0 0 0.04 +- 0.13 4

No common domains found
Streptomyces sp. NRRL F-5065 383.45 +- 132.55 2 0 0 1 0.05 +- 0.04 2 32

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13671 (1/2) AAA domain
PF13560 (1/2) Helix-turn-helix domain
PF11723 (1/2) Homotrimeric ring hydroxylase
PF05331 (1/2) Protein of unknown function (DUF742)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03972 (1/2) MmgE/PrpD family
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (1/2) GAF domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01327 (1/2) Polypeptide deformylase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (1/2) Glycosyl hydrolases family 15
PF00561 (1/2) alpha/beta hydrolase fold
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00293 (1/2) NUDIX domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter
Streptomyces albus 344.00 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF14759 (1/1) Reductase C-terminal
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/1) Major Facilitator Superfamily
PF04237 (1/1) YjbR
PF00067 (1/1) Cytochrome P450
Streptomyces sp. NRRL F-5630 212.72 +- 96.88 2 0 1 1 0.07 +- 0.10 2 21

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (1/2) heavy metal translocating P-type ATPase
PF17197 (1/2) Domain of unknown function (DUF5134)
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF08281 (1/2) Sigma-70, region 4
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03551 (1/2) Transcriptional regulator PadR-like family
PF03412 (1/2) Peptidase C39 family
PF01965 (1/2) DJ-1/PfpI family
PF01569 (1/2) PAP2 superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00403 (1/2) Heavy-metal-associated domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter
Streptomyces antioxidans 268.67 +- 34.67 2 0 0 0 0.05 +- 0.07 2 19

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (2/2) Major Facilitator Superfamily
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (2/2) AMP-binding enzyme
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13378 (1/2) Enolase C-terminal domain-like
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01425 (1/2) Amidase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF01230 (1/2) HIT domain
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. 2133.1 110.58 +- 75.13 2 0 0 0 0.05 +- 0.06 2 9

PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05331 (1/2) Protein of unknown function (DUF742)
PF04149 (1/2) Domain of unknown function (DUF397)
PF03713 (1/2) Domain of unknown function (DUF305)
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00067 (1/2) Cytochrome P450
Streptomyces sp. LamerLS-31b 276.98 +- 327.62 4 0 2 0 0.05 +- 0.09 4 3

PF07690 (3/4) Major Facilitator Superfamily
PF08281 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
Streptomyces sparsogenes DSM 40356 393.32 +- 173.95 2 0 2 1 0.03 +- 0.04 2 22

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR01534 (1/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03936 (1/2) Terpene synthase family, metal binding domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF03412 (1/2) Peptidase C39 family
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02800 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00664 (1/2) ABC transporter transmembrane region
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00348 (1/2) Polyprenyl synthetase
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00044 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
PF00005 (1/2) ABC transporter
Streptomyces niveus 967.50 +- 0.00 1 0 0 0 0.01 +- 0.00 1 5

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF08402 (1/1) TOBE domain
PF00962 (1/1) Adenosine/AMP deaminase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter
Streptomyces agglomeratus 471.89 +- 410.47 2 0 2 0 0.05 +- 0.14 2 48

TIGR02965 (1/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (1/2) xanthine dehydrogenase accessory protein XdhC
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13478 (1/2) XdhC Rossmann domain
PF13458 (1/2) Periplasmic binding protein
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02625 (1/2) XdhC and CoxI family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01070 (1/2) FMN-dependent dehydrogenase
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00756 (1/2) Putative esterase
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00384 (1/2) Molybdopterin oxidoreductase
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter
Streptomyces sp. 93 3405.60 +- 0.00 1 0 0 0 0.01 +- 0.01 1 13

TIGR01263 (1/1) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF14696 (1/1) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (1/1) ATP-grasp domain
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (1/1) Prephenate dehydrogenase
PF01613 (1/1) Flavin reductase like domain
PF01070 (1/1) FMN-dependent dehydrogenase
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (1/1) Luciferase-like monooxygenase
PF00155 (1/1) Aminotransferase class I and II
PF00106 (1/1) short chain dehydrogenase
Streptomyces jeddahensis 260.90 +- 42.29 3 0 0 1 0.05 +- 0.07 3

No common domains found
Streptomyces sp. MJM1172 581.24 +- 685.62 5 0 2 1 0.03 +- 0.03 5

No common domains found
Streptomyces pristinaespiralis ATCC 25486 425.45 +- 0.00 1 0 0 0 0.04 +- 0.02 1 16

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces sp. EAG2 451.50 +- 193.50 2 0 0 0 0.01 +- 0.00 2 10

PF00561 (2/2) alpha/beta hydrolase fold
PF12697 (1/2) Alpha/beta hydrolase family
PF11723 (1/2) Homotrimeric ring hydroxylase
PF08386 (1/2) TAP-like protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces sviceus ATCC 29083 367.58 +- 597.28 5 0 1 1 0.05 +- 0.10 5

No common domains found
Streptomyces sp. CNQ-509 611.99 +- 391.33 6 0 3 0 0.01 +- 0.01 6

No common domains found
Streptomyces pratensis ATCC 33331 485.33 +- 0.00 1 0 1 1 0.01 +- 0.00 1 7

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF03466 (1/1) LysR substrate binding domain
PF02310 (1/1) B12 binding domain
PF00733 (1/1) Asparagine synthase
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces viridochromogenes 367.21 +- 79.01 3 0 1 0 0.02 +- 0.01 3

No common domains found
Streptomyces sp. NRRL S-1868 358.89 +- 216.13 3 0 0 1 0.02 +- 0.02 3

No common domains found
Streptomyces sp. NRRL B-24085 838.50 +- 709.50 2 0 1 0 0.01 +- 0.00 2 11

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08007 (1/2) Cupin superfamily protein
PF03412 (1/2) Peptidase C39 family
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01464 (1/2) Transglycosylase SLT domain
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00005 (1/2) ABC transporter
Streptomyces sp. DpondAA-A50 216.34 +- 127.66 2 0 2 0 0.05 +- 0.09 2 24

TIGR01891 (1/2) amidohydrolase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (1/2) Zinc-binding dehydrogenase
Streptomyces sp. CNB091 258.00 +- 0.00 1 0 0 0 0.04 +- 0.02 1 8

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces durhamensis 490.71 +- 218.20 3 0 3 1 0.01 +- 0.02 3

No common domains found
Streptomyces sp. CNZ306 285.81 +- 215.38 4 0 0 0 0.05 +- 0.10 4 2

PF13416 (2/4) Bacterial extracellular solute-binding protein
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
Streptomyces regalis 227.69 +- 209.03 3 0 1 0 0.03 +- 0.04 3

No common domains found
Streptomyces coelicolor A3(2) 264.81 +- 0.00 1 0 1 1 0.04 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces sp. CcalMP-8W 637.54 +- 0.00 1 0 1 0 0.07 +- 0.22 1 19

TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR01356 (1/1) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/1) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF18130 (1/1) ATP-grasp N-terminal domain
PF13549 (1/1) ATP-grasp domain
PF13535 (1/1) ATP-grasp domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF13115 (1/1) YtkA-like
PF04389 (1/1) Peptidase family M28
PF02627 (1/1) Carboxymuconolactone decarboxylase family
PF01676 (1/1) Metalloenzyme superfamily
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00664 (1/1) ABC transporter transmembrane region
PF00403 (1/1) Heavy-metal-associated domain
PF00275 (1/1) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/1) Aminotransferase class I and II
PF00122 (1/1) E1-E2 ATPase
PF00117 (1/1) Glutamine amidotransferase class-I
PF00005 (1/1) ABC transporter
Streptomyces agglomeratus 2157.83 +- 1185.02 2 0 2 1 0.03 +- 0.14 2 41

PF00005 (2/2) ABC transporter
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13458 (1/2) Periplasmic binding protein
PF12730 (1/2) ABC-2 family transporter protein
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00384 (1/2) Molybdopterin oxidoreductase
PF00296 (1/2) Luciferase-like monooxygenase
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00069 (1/2) Protein kinase domain
Streptomyces sp. NRRL S-337 173.58 +- 93.70 4 0 2 0 0.03 +- 0.04 4

No common domains found
Streptomyces sp. CNZ288 380.36 +- 133.98 3 0 1 0 0.02 +- 0.02 3

No common domains found
Streptomyces sp. CB01373 24.76 +- 0.00 1 0 0 0 0.08 +- 0.07 1 3

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF01522 (1/1) Polysaccharide deacetylase
Streptomyces silvensis 268.75 +- 168.50 3 0 1 2 0.04 +- 0.14 3 1

PF04055 (2/3) Radical SAM superfamily
Streptomyces sp. MJM8645 258.31 +- 187.40 2 0 2 1 0.03 +- 0.04 2 13

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF08877 (1/2) MepB protein
PF08453 (1/2) Peptidase family M9 N-terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01764 (1/2) Lipase (class 3)
PF01752 (1/2) Collagenase
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00326 (1/2) Prolyl oligopeptidase family
PF00067 (1/2) Cytochrome P450
Streptomyces sp. DSM 15324 294.16 +- 248.47 3 0 1 0 0.03 +- 0.05 3 2

PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00004 (2/3) ATPase family associated with various cellular activities (AAA)
Streptomyces sp. yr375 237.08 +- 134.92 3 0 1 1 0.08 +- 0.23 3

No common domains found
Streptomyces auratus AGR0001 200.37 +- 37.42 2 0 2 1 0.06 +- 0.20 2 26

PF07690 (2/2) Major Facilitator Superfamily
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
TIGR00229 (1/2) PAS domain S-box protein
TIGR00178 (1/2) isocitrate dehydrogenase, NADP-dependent
PF13632 (1/2) Glycosyl transferase family group 2
PF13426 (1/2) PAS domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13191 (1/2) AAA ATPase domain
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04321 (1/2) RmlD substrate binding domain
PF04055 (1/2) Radical SAM superfamily
PF03971 (1/2) Monomeric isocitrate dehydrogenase
PF02310 (1/2) B12 binding domain
PF01979 (1/2) Amidohydrolase family
PF01590 (1/2) GAF domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00535 (1/2) Glycosyl transferase family 2
PF00480 (1/2) ROK family
PF00459 (1/2) Inositol monophosphatase family
PF00326 (1/2) Prolyl oligopeptidase family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces sp. WAC05458 356.43 +- 276.61 2 0 0 0 0.04 +- 0.04 2 19

PF01425 (2/2) Amidase
TIGR00928 (1/2) adenylosuccinate lyase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13460 (1/2) NAD(P)H-binding
PF12800 (1/2) 4Fe-4S binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF07681 (1/2) DoxX
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01494 (1/2) FAD binding domain
PF01427 (1/2) D-ala-D-ala dipeptidase
PF00561 (1/2) alpha/beta hydrolase fold
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00293 (1/2) NUDIX domain
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00072 (1/2) Response regulator receiver domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces sp. WM6372 1117.74 +- 1791.14 5 0 3 1 0.02 +- 0.01 5

No common domains found
Streptomyces hygroscopicus subsp. hygroscopicus 169.85 +- 112.75 7 0 1 1 0.04 +- 0.04 7

No common domains found
Streptomyces sp. E5N298 516.00 +- 0.00 1 0 0 0 0.02 +- 0.01 1 5

PF13631 (1/1) Cytochrome b(N-terminal)/b6/petB
PF07504 (1/1) Fungalysin/Thermolysin Propeptide Motif
PF05630 (1/1) Necrosis inducing protein (NPP1)
PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain
Streptomyces lividans TK24 184.29 +- 0.00 1 0 1 1 0.06 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces sp. Ag82_O1-15 191.46 +- 93.23 2 0 1 0 0.06 +- 0.12 2 24

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13460 (1/2) NAD(P)H-binding
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (1/2) Major Facilitator Superfamily
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (1/2) Thioesterase domain
PF00877 (1/2) NlpC/P60 family
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. Ru72 320.42 +- 0.00 1 0 0 0 0.03 +- 0.03 1 6

PF16925 (1/1) Tetracyclin repressor-like, C-terminal domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF06779 (1/1) Uncharacterised MFS-type transporter YbfB
PF01965 (1/1) DJ-1/PfpI family
PF00440 (1/1) Bacterial regulatory proteins, tetR family
Streptomyces sp. MBT76 970.68 +- 552.63 5 0 2 0 0.01 +- 0.01 5

No common domains found
Streptomyces sp. CNS615 1526.50 +- 1483.50 2 0 2 1 0.03 +- 0.05 2 14

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/2) Helix-turn-helix domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF04149 (1/2) Domain of unknown function (DUF397)
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00905 (1/2) Penicillin binding protein transpeptidase domain
PF00881 (1/2) Nitroreductase family
PF00266 (1/2) Aminotransferase class-V
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
Streptomyces globisporus subsp. globisporus 425.70 +- 0.00 1 0 0 0 0.02 +- 0.02 1 7

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces monomycini 176.43 +- 46.43 2 0 2 1 0.02 +- 0.02 2 8

TIGR00229 (1/2) PAS domain S-box protein
PF13471 (1/2) Transglutaminase-like superfamily
PF08448 (1/2) PAS fold
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01979 (1/2) Amidohydrolase family
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00733 (1/2) Asparagine synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces misionensis 177.93 +- 150.06 3 0 1 1 0.03 +- 0.04 3

No common domains found
Streptomyces hoynatensis 677.93 +- 507.14 3 0 0 2 0.01 +- 0.02 3

No common domains found
Streptomyces sp. Ag109_O5-1 312.81 +- 169.79 5 0 1 0 0.02 +- 0.06 5

No common domains found
Candidatus Streptomyces philanthi 128.40 +- 0.00 1 0 0 0 0.06 +- 0.05 1 13

PF13377 (1/1) Periplasmic binding protein-like domain
PF10022 (1/1) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (1/1) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF07045 (1/1) Domain of unknown function (DUF1330)
PF04030 (1/1) D-arabinono-1,4-lactone oxidase
PF02884 (1/1) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (1/1) Polysaccharide lyase family 8, super-sandwich domain
PF01565 (1/1) FAD binding domain
PF00722 (1/1) Glycosyl hydrolases family 16
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00067 (1/1) Cytochrome P450
Streptomyces bottropensis ATCC 25435 3120.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 13

TIGR04245 (1/1) N-acyltransferase NodA
TIGR04243 (1/1) chitooligosaccharide deacetylase NodB
TIGR04242 (1/1) chitooligosaccharide synthase NodC
TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02474 (1/1) Nodulation protein A (NodA)
PF01522 (1/1) Polysaccharide deacetylase
PF01061 (1/1) ABC-2 type transporter
PF00535 (1/1) Glycosyl transferase family 2
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL S-15 119.08 +- 41.08 2 0 0 1 0.07 +- 0.09 2 19

PF13581 (1/2) Histidine kinase-like ATPase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13191 (1/2) AAA ATPase domain
PF12802 (1/2) MarR family
PF09346 (1/2) SMI1 / KNR4 family (SUKH-1)
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF01614 (1/2) Bacterial transcriptional regulator
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter
Streptomyces albidoflavus 258.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF01757 (1/1) Acyltransferase family
PF00248 (1/1) Aldo/keto reductase family
Streptomyces kanasensis 618.38 +- 0.00 1 0 0 1 0.03 +- 0.03 1 11

TIGR04469 (1/1) CGA synthase-related protein
TIGR04468 (1/1) arginine 2,3-aminomutase
TIGR04467 (1/1) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (1/1) cytosylglucuronate decarboxylase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF05014 (1/1) Nucleoside 2-deoxyribosyltransferase
PF04055 (1/1) Radical SAM superfamily
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces hygroscopicus subsp. hygroscopicus 263.15 +- 138.65 5 0 0 0 0.03 +- 0.05 5

No common domains found
Streptomyces sp. CS057 304.39 +- 0.00 1 0 1 0 0.04 +- 0.04 1 6

TIGR03892 (1/1) thiazolylpeptide-type bacteriocin precursor
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF01959 (1/1) 3-dehydroquinate synthase II
PF01791 (1/1) DeoC/LacD family aldolase
PF01494 (1/1) FAD binding domain
PF00501 (1/1) AMP-binding enzyme
Streptomyces angustmyceticus 1231.32 +- 1108.68 2 0 1 1 0.03 +- 0.05 2 15

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (1/2) 2-dehydropantoate 2-reductase
PF09084 (1/2) NMT1/THI5 like
PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02597 (1/2) ThiS family
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF02310 (1/2) B12 binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00155 (1/2) Aminotransferase class I and II
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
Streptomyces sp. CNH287 1161.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 9

PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF03704 (1/1) Bacterial transcriptional activator domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces sp. WAC05858 51.60 +- 0.00 1 0 0 0 0.04 +- 0.03 1 2

PF01048 (1/1) Phosphorylase superfamily
PF00293 (1/1) NUDIX domain
Streptomyces sp. wa1002 22.61 +- 0.00 1 0 0 0 0.09 +- 0.08 1 2

PF13673 (1/1) Acetyltransferase (GNAT) domain
PF01872 (1/1) RibD C-terminal domain
Streptomyces chattanoogensis 242.77 +- 136.40 2 0 2 1 0.03 +- 0.02 2 13

PF00005 (2/2) ABC transporter
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03731 (1/2) lantibiotic, gallidermin/nisin family
TIGR02276 (1/2) 40-residue YVTN family beta-propeller repeat
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF10282 (1/2) Lactonase, 7-bladed beta-propeller
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04072 (1/2) Leucine carboxyl methyltransferase
PF02052 (1/2) Gallidermin
PF01061 (1/2) ABC-2 type transporter
PF00664 (1/2) ABC transporter transmembrane region
PF00069 (1/2) Protein kinase domain
Streptomyces avidinii 188.43 +- 122.64 3 0 1 1 0.04 +- 0.08 3 1

PF00440 (2/3) Bacterial regulatory proteins, tetR family
Streptomyces fungicidicus 390.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
Streptomyces sp. ZS0098 516.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 8

PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00550 (1/1) Phosphopantetheine attachment site
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Streptomyces sp. SM13 448.42 +- 177.41 3 0 3 2 0.06 +- 0.07 3 3

PF00005 (3/3) ABC transporter
PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
Streptomyces sp. CS113 660.18 +- 629.82 2 0 1 0 0.02 +- 0.02 2 12

TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF10502 (1/2) Signal peptidase, peptidase S26
PF07291 (1/2) Methylamine utilisation protein MauE
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03704 (1/2) Bacterial transcriptional activator domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00931 (1/2) NB-ARC domain
PF00899 (1/2) ThiF family
PF00717 (1/2) Peptidase S24-like
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter
Streptomyces sp. 3212.4 794.07 +- 758.65 5 0 2 1 0.04 +- 0.10 5 1

PF00005 (3/5) ABC transporter
Streptomyces sp. I6 119.08 +- 0.00 1 0 0 0 0.03 +- 0.04 1 6

PF13411 (1/1) MerR HTH family regulatory protein
PF07690 (1/1) Major Facilitator Superfamily
PF04909 (1/1) Amidohydrolase
PF02945 (1/1) Recombination endonuclease VII
PF01794 (1/1) Ferric reductase like transmembrane component
PF00175 (1/1) Oxidoreductase NAD-binding domain
Streptomyces platensis 258.03 +- 169.34 4 0 2 0 0.04 +- 0.10 4 1

PF01494 (2/4) FAD binding domain
Streptomyces sp. TLI_235 541.67 +- 542.10 3 0 1 1 0.02 +- 0.02 3

No common domains found
Streptomyces griseoplanus 270.45 +- 55.45 2 0 0 0 0.04 +- 0.04 2 13

TIGR03086 (1/2) TIGR03086 family protein
TIGR01891 (1/2) amidohydrolase
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09084 (1/2) NMT1/THI5 like
PF07920 (1/2) Protein of unknown function (DUF1684)
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01546 (1/2) Peptidase family M20/M25/M40
PF00581 (1/2) Rhodanese-like domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00376 (1/2) MerR family regulatory protein
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. or3 294.86 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/1) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/1) YbaB/EbfC DNA-binding family
Streptomyces sp. CC77 1040.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 12

TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
PF13489 (1/1) Methyltransferase domain
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13394 (1/1) 4Fe-4S single cluster domain
PF04055 (1/1) Radical SAM superfamily
PF02223 (1/1) Thymidylate kinase
PF01259 (1/1) SAICAR synthetase
PF01242 (1/1) 6-pyruvoyl tetrahydropterin synthase
PF01227 (1/1) GTP cyclohydrolase I
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00929 (1/1) Exonuclease
PF00156 (1/1) Phosphoribosyl transferase domain
Streptomyces sp. t99 164.18 +- 0.00 1 0 0 0 0.04 +- 0.02 1 5

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
Streptomyces sp. NRRL F-5639 195.00 +- 65.00 2 0 0 0 0.01 +- 0.01 2 3

PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03130 (1/2) PBS lyase HEAT-like repeat
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
Streptomyces rimosus subsp. rimosus 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces cinnamoneus 516.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 7

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (1/1) luciferase family oxidoreductase, group 1
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. 2233.2 704.49 +- 736.25 3 0 1 1 0.03 +- 0.06 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. CS227 194.62 +- 33.37 2 0 0 0 0.07 +- 0.07 2 29

TIGR00745 (1/2) 2-dehydropantoate 2-reductase
TIGR00055 (1/2) di-trans,poly-cis-decaprenylcistransferase
PF14310 (1/2) Fibronectin type III-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (1/2) Peptidase_C39 like family
PF13515 (1/2) Fusaric acid resistance protein-like
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13202 (1/2) EF hand
PF12833 (1/2) Helix-turn-helix domain
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal
PF08386 (1/2) TAP-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF01965 (1/2) DJ-1/PfpI family
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01546 (1/2) Peptidase family M20/M25/M40
PF01522 (1/2) Polysaccharide deacetylase
PF01471 (1/2) Putative peptidoglycan binding domain
PF01255 (1/2) Putative undecaprenyl diphosphate synthase
PF01037 (1/2) Lrp/AsnC ligand binding domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00083 (1/2) Sugar (and other) transporter
Streptomyces hygroscopicus subsp. hygroscopicus 268.35 +- 119.41 4 0 0 0 0.02 +- 0.01 4 1

PF07690 (3/4) Major Facilitator Superfamily
Streptomyces sp. H021 618.44 +- 542.56 2 0 0 1 0.03 +- 0.05 2 29

TIGR02493 (1/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (1/2) pyruvate, phosphate dikinase
TIGR01426 (1/2) glycosyltransferase, MGT family
TIGR01255 (1/2) formate acetyltransferase
PF17914 (1/2) HopA1 effector protein family
PF14325 (1/2) Domain of unknown function (DUF4383)
PF13692 (1/2) Glycosyl transferases group 1
PF13601 (1/2) Winged helix DNA-binding domain
PF13411 (1/2) MerR HTH family regulatory protein
PF12698 (1/2) ABC-2 family transporter protein
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02901 (1/2) Pyruvate formate lyase-like
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (1/2) B12 binding domain
PF02441 (1/2) Flavoprotein
PF01636 (1/2) Phosphotransferase enzyme family
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (1/2) Glycine radical
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00582 (1/2) Universal stress protein family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces alfalfae 246.07 +- 192.36 5 0 2 3 0.04 +- 0.13 5 2

PF07690 (3/5) Major Facilitator Superfamily
PF04055 (3/5) Radical SAM superfamily
Streptomyces griseus subsp. griseus 1043.58 +- 742.58 2 0 1 1 0.02 +- 0.02 2 14

TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12679 (1/2) ABC-2 family transporter protein
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF03412 (1/2) Peptidase C39 family
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter
Streptomyces sp. 1121.2 661.82 +- 378.18 2 0 0 1 0.06 +- 0.08 2 18

TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01234 (1/2) ribulokinase
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14016 (1/2) Protein of unknown function (DUF4232)
PF11762 (1/2) L-arabinose isomerase C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF05193 (1/2) Peptidase M16 inactive domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02610 (1/2) L-arabinose isomerase
PF02517 (1/2) CPBP intramembrane metalloprotease
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
Streptomyces torulosus 244.42 +- 0.00 1 0 0 0 0.02 +- 0.01 1 9

TIGR01296 (1/1) aspartate-semialdehyde dehydrogenase
PF12833 (1/1) Helix-turn-helix domain
PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (1/1) DJ-1/PfpI family
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (1/1) Amino acid kinase family
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00171 (1/1) Aldehyde dehydrogenase family
Streptomyces sp. IGB124 856.51 +- 814.91 2 0 1 0 0.02 +- 0.03 2 20

TIGR01426 (1/2) glycosyltransferase, MGT family
PF18616 (1/2) CDI immunity proteins
PF18029 (1/2) Glyoxalase-like domain
PF17914 (1/2) HopA1 effector protein family
PF13692 (1/2) Glycosyl transferases group 1
PF13649 (1/2) Methyltransferase domain
PF13601 (1/2) Winged helix DNA-binding domain
PF12698 (1/2) ABC-2 family transporter protein
PF06276 (1/2) Ferric iron reductase FhuF-like transporter
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF04183 (1/2) IucA / IucC family
PF02441 (1/2) Flavoprotein
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/2) ABC transporter
Streptomyces albidoflavus 690.33 +- 625.33 2 0 1 0 0.04 +- 0.06 2 36

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12770 (1/2) CHAT domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF07510 (1/2) Protein of unknown function (DUF1524)
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03235 (1/2) Protein of unknown function DUF262
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01636 (1/2) Phosphotransferase enzyme family
PF01609 (1/2) Transposase DDE domain
PF01497 (1/2) Periplasmic binding protein
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF01032 (1/2) FecCD transport family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter
Streptomyces sp. KS_5 338.45 +- 181.55 2 0 0 1 0.03 +- 0.04 2 17

TIGR04267 (1/2) HEXXH motif domain
TIGR01187 (1/2) polyamine ABC transporter, ATP-binding protein
TIGR00702 (1/2) YcaO-type kinase domain
PF18029 (1/2) Glyoxalase-like domain
PF13489 (1/2) Methyltransferase domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08402 (1/2) TOBE domain
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
Streptomyces sp. WAC 06783 227.50 +- 315.57 4 0 1 2 0.03 +- 0.03 4 1

PF00733 (2/4) Asparagine synthase
Streptomyces sp. Amel2xB2 190.87 +- 90.07 3 0 1 0 0.06 +- 0.14 3 2

PF07729 (2/3) FCD domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family
Streptomyces rimosus subsp. rimosus 131.15 +- 44.17 3 0 1 1 0.03 +- 0.04 3

No common domains found
Streptomyces sp. M3 230.24 +- 94.74 4 0 2 0 0.05 +- 0.10 4 1

PF07690 (2/4) Major Facilitator Superfamily
Streptomyces viridochromogenes 500.90 +- 402.10 2 0 1 0 0.04 +- 0.06 2 31

TIGR03425 (1/2) urea carboxylase-associated protein 2
TIGR03424 (1/2) urea carboxylase-associated protein 1
TIGR02712 (1/2) urea carboxylase
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13520 (1/2) Amino acid permease
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13394 (1/2) 4Fe-4S single cluster domain
PF09347 (1/2) Domain of unknown function (DUF1989)
PF07690 (1/2) Major Facilitator Superfamily
PF06508 (1/2) Queuosine biosynthesis protein QueC
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF02803 (1/2) Thiolase, C-terminal domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02682 (1/2) Carboxyltransferase domain, subdomain C and D
PF02626 (1/2) Carboxyltransferase domain, subdomain A and B
PF02310 (1/2) B12 binding domain
PF01425 (1/2) Amidase
PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (1/2) GTP cyclohydrolase I
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00108 (1/2) Thiolase, N-terminal domain
Streptomyces sp. SM1 331.96 +- 0.00 1 0 0 0 0.04 +- 0.01 1 13

TIGR03561 (1/1) peroxiredoxin, Ohr subfamily
PF13649 (1/1) Methyltransferase domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/1) IclR helix-turn-helix domain
PF09084 (1/1) NMT1/THI5 like
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF02566 (1/1) OsmC-like protein
PF01614 (1/1) Bacterial transcriptional regulator
PF01546 (1/1) Peptidase family M20/M25/M40
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/1) alpha/beta hydrolase fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter
Streptomyces wedmorensis 752.38 +- 183.71 4 0 2 1 0.02 +- 0.01 4 3

PF13378 (2/4) Enolase C-terminal domain-like
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00005 (2/4) ABC transporter
Streptomyces prunicolor NBRC 13075 188.34 +- 118.24 3 0 0 0 0.04 +- 0.10 3

No common domains found
Streptomyces sp. NBRC 110468 120.12 +- 80.47 3 0 1 1 0.06 +- 0.16 3

No common domains found
Streptomyces sioyaensis 646.47 +- 30.78 2 0 2 0 0.01 +- 0.01 2 22

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
TIGR01392 (1/2) homoserine O-acetyltransferase
TIGR01326 (1/2) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13191 (1/2) AAA ATPase domain
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF07722 (1/2) Peptidase C26
PF07690 (1/2) Major Facilitator Superfamily
PF04321 (1/2) RmlD substrate binding domain
PF04185 (1/2) Phosphoesterase family
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01979 (1/2) Amidohydrolase family
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00892 (1/2) EamA-like transporter family
PF00561 (1/2) alpha/beta hydrolase fold
PF00535 (1/2) Glycosyl transferase family 2
PF00487 (1/2) Fatty acid desaturase
PF00480 (1/2) ROK family
PF00459 (1/2) Inositol monophosphatase family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces sp. RV15 258.00 +- 0.00 1 0 1 0 0.02 +- 0.02 1 5

PF13523 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00501 (1/1) AMP-binding enzyme
PF00106 (1/1) short chain dehydrogenase
Streptomyces sp. SS 761.41 +- 591.24 3 0 2 1 0.02 +- 0.01 3

No common domains found
Streptomyces sp. E2N166 520.00 +- 0.00 1 0 0 0 0.02 +- 0.01 1 4

PF13649 (1/1) Methyltransferase domain
PF12698 (1/1) ABC-2 family transporter protein
PF02441 (1/1) Flavoprotein
PF00005 (1/1) ABC transporter
Streptomyces sp. CNT371 577.33 +- 196.67 2 0 1 0 0.03 +- 0.02 2 28

TIGR01733 (1/2) amino acid adenylation domain
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF17645 (1/2) Arylmalonate decarboxylase
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05685 (1/2) Putative restriction endonuclease
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02426 (1/2) Muconolactone delta-isomerase
PF01636 (1/2) Phosphotransferase enzyme family
PF01614 (1/2) Bacterial transcriptional regulator
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (1/2) Prolyl oligopeptidase family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter
Streptomyces uncialis 497.47 +- 317.11 6 0 1 0 0.02 +- 0.03 6

No common domains found
Streptomyces sp. CB02613 2064.71 +- 0.00 1 0 1 1 0.01 +- 0.01 1 9

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03703 (1/1) Bacterial PH domain
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter
Streptomyces fradiae 96.18 +- 0.00 1 0 1 0 0.08 +- 0.19 1 25

TIGR01762 (1/1) chlorinating enzyme
TIGR01733 (1/1) amino acid adenylation domain
TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
TIGR01444 (1/1) methyltransferase, FkbM family
TIGR00843 (1/1) benzoate transporter
PF16990 (1/1) Carbohydrate binding module (family 35)
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF13454 (1/1) FAD-NAD(P)-binding
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07691 (1/1) PA14 domain
PF06439 (1/1) Domain of Unknown Function (DUF1080)
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (1/1) Methyltransferase FkbM domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF03594 (1/1) Benzoate membrane transport protein
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01116 (1/1) Fructose-bisphosphate aldolase class-II
PF00975 (1/1) Thioesterase domain
PF00892 (1/1) EamA-like transporter family
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
Streptomyces cinnamoneus 162.58 +- 127.13 2 0 0 0 0.06 +- 0.10 2 21

PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13671 (1/2) AAA domain
PF13535 (1/2) ATP-grasp domain
PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C
PF12833 (1/2) Helix-turn-helix domain
PF11706 (1/2) CGNR zinc finger
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF07336 (1/2) Putative stress-induced transcription regulator
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (1/2) DJ-1/PfpI family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (1/2) Amino acid kinase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00107 (1/2) Zinc-binding dehydrogenase
Streptomyces sp. WAC 01325 354.75 +- 161.25 2 0 0 1 0.01 +- 0.01 2 13

TIGR01840 (1/2) esterase, PHB depolymerase family
TIGR00702 (1/2) YcaO-type kinase domain
TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF18029 (1/2) Glyoxalase-like domain
PF14016 (1/2) Protein of unknown function (DUF4232)
PF13489 (1/2) Methyltransferase domain
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF10503 (1/2) Esterase PHB depolymerase
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
PF00067 (1/2) Cytochrome P450
Streptomyces sp. GP55 47.12 +- 16.48 5 0 3 1 0.06 +- 0.04 5

No common domains found
Streptomyces sp. WAC 05977 150.94 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

TIGR00398 (1/1) methionine--tRNA ligase
TIGR00010 (1/1) hydrolase, TatD family
PF09334 (1/1) tRNA synthetases class I (M)
PF07501 (1/1) G5 domain
PF06737 (1/1) Transglycosylase-like domain
PF03990 (1/1) G5-linked-Ubiquitin-like domain
PF01026 (1/1) TatD related DNase
Streptomyces albus 196.30 +- 0.00 1 0 1 1 0.07 +- 0.09 1 12

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00931 (1/1) NB-ARC domain
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter
Streptomyces sp. TSRI0261 478.70 +- 415.73 5 0 2 1 0.04 +- 0.04 5

No common domains found
Streptomyces leeuwenhoekii 1677.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 8

PF17914 (1/1) HopA1 effector protein family
PF02441 (1/1) Flavoprotein
PF01061 (1/1) ABC-2 type transporter
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. L2 1418.18 +- 0.00 1 0 0 0 0.01 +- 0.00 1 8

PF13738 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07722 (1/1) Peptidase C26
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (1/1) Aminotransferase class-III
PF00171 (1/1) Aldehyde dehydrogenase family
PF00120 (1/1) Glutamine synthetase, catalytic domain
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces sp. 67 1182.19 +- 402.19 2 0 1 1 0.04 +- 0.15 2 41

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03856 (1/2) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01686 (1/2) FkbH domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF18563 (1/2) TubC N-terminal docking domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF16058 (1/2) Mucin-like
PF14765 (1/2) Polyketide synthase dehydratase
PF13602 (1/2) Zinc-binding dehydrogenase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF03972 (1/2) MmgE/PrpD family
PF03621 (1/2) MbtH-like protein
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02195 (1/2) ParB-like nuclease domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (1/2) FAD dependent oxidoreductase
PF00975 (1/2) Thioesterase domain
PF00881 (1/2) Nitroreductase family
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (1/2) Acyl transferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter
Streptomyces wuyuanensis 394.48 +- 0.00 1 0 1 0 0.03 +- 0.03 1 9

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF13377 (1/1) Periplasmic binding protein-like domain
PF11941 (1/1) Domain of unknown function (DUF3459)
PF03777 (1/1) ChpA-C
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00293 (1/1) NUDIX domain
PF00128 (1/1) Alpha amylase, catalytic domain
Streptomyces sp. IMTB 2501 397.17 +- 301.03 4 0 0 0 0.04 +- 0.14 4

No common domains found
Streptomyces microflavus 79.68 +- 49.32 2 0 0 0 0.09 +- 0.12 2 15

PF00440 (2/2) Bacterial regulatory proteins, tetR family
TIGR00229 (1/2) PAS domain S-box protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (1/2) SnoaL-like domain
PF08448 (1/2) PAS fold
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF07045 (1/2) Domain of unknown function (DUF1330)
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01738 (1/2) Dienelactone hydrolase family
PF01590 (1/2) GAF domain
PF00664 (1/2) ABC transporter transmembrane region
PF00455 (1/2) DeoR C terminal sensor domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces lydicus 651.76 +- 359.14 3 0 2 2 0.02 +- 0.03 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. IgraMP-1 241.43 +- 0.00 1 0 0 0 0.05 +- 0.10 1 15

TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (1/1) Domain of unknown function (DUF4380)
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13407 (1/1) Periplasmic binding protein domain
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF01081 (1/1) KDPG and KHG aldolase
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00107 (1/1) Zinc-binding dehydrogenase
PF00005 (1/1) ABC transporter
Streptomyces parvulus 1765.69 +- 1717.31 2 0 0 0 0.01 +- 0.02 2 28

TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12680 (1/2) SnoaL-like domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05199 (1/2) GMC oxidoreductase
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02571 (1/2) Precorrin-6x reductase CbiJ/CobK
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region
PF00732 (1/2) GMC oxidoreductase
PF00561 (1/2) alpha/beta hydrolase fold
PF00544 (1/2) Pectate lyase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00450 (1/2) Serine carboxypeptidase
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00326 (1/2) Prolyl oligopeptidase family
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
Streptomyces sp. NRRL S-37 681.06 +- 0.00 1 0 0 1 0.05 +- 0.03 1 20

TIGR04364 (1/1) methyltransferase, FxLD system
TIGR04363 (1/1) FxLD family lantipeptide
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13649 (1/1) Methyltransferase domain
PF05331 (1/1) Protein of unknown function (DUF742)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03259 (1/1) Roadblock/LC7 domain
PF03029 (1/1) Conserved hypothetical ATP binding protein
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01590 (1/1) GAF domain
PF01427 (1/1) D-ala-D-ala dipeptidase
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (1/1) Glycosyl hydrolases family 15
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (1/1) NUDIX domain
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces catenulae 436.62 +- 0.00 1 0 0 0 0.01 +- 0.00 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF17866 (1/1) AAA lid domain
PF13229 (1/1) Right handed beta helix region
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00004 (1/1) ATPase family associated with various cellular activities (AAA)
Streptomyces sp. SolWspMP-sol2th 663.56 +- 614.03 2 0 1 0 0.03 +- 0.03 2 20

TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13115 (1/2) YtkA-like
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF01676 (1/2) Metalloenzyme superfamily
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00403 (1/2) Heavy-metal-associated domain
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter
Streptomyces pluripotens 975.00 +- 325.00 2 0 1 1 0.01 +- 0.00 2 12

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
PF17933 (1/2) Tetracyclin repressor-like, C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF06100 (1/2) MCRA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/2) CPBP intramembrane metalloprotease
PF01553 (1/2) Acyltransferase
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces venezuelae 2604.19 +- 3271.71 3 0 2 2 0.02 +- 0.04 3

No common domains found
Streptomyces acidiscabies 346.67 +- 0.00 1 0 0 0 0.09 +- 0.23 1 19

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF10901 (1/1) Protein of unknown function (DUF2690)
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01471 (1/1) Putative peptidoglycan binding domain
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00664 (1/1) ABC transporter transmembrane region
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00005 (1/1) ABC transporter
Streptomyces sp. MMG1121 250.83 +- 7.17 2 0 1 0 0.09 +- 0.22 2 34

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (1/2) amino acid adenylation domain
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13602 (1/2) Zinc-binding dehydrogenase
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08990 (1/2) Erythronolide synthase docking
PF08659 (1/2) KR domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00696 (1/2) Amino acid kinase family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (1/2) Cytochrome P450
Streptomyces sp. ADI98-12 41.61 +- 0.00 1 0 1 0 0.10 +- 0.09 1 4

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (1/1) Major Facilitator Superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00067 (1/1) Cytochrome P450
Streptomyces albidoflavus 440.26 +- 0.00 1 0 1 0 0.09 +- 0.09 1 25

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces sp. CB02959 60.00 +- 0.00 1 0 0 0 0.05 +- 0.07 1 11

PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13333 (1/1) Integrase core domain
PF13276 (1/1) HTH-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF04309 (1/1) Glycerol-3-phosphate responsive antiterminator
PF02913 (1/1) FAD linked oxidases, C-terminal domain
PF02782 (1/1) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (1/1) FAD binding domain
PF01527 (1/1) Transposase
PF00665 (1/1) Integrase core domain
PF00370 (1/1) FGGY family of carbohydrate kinases, N-terminal domain
Streptomyces sp. IB2014 011-12 209.79 +- 255.39 4 0 1 1 0.05 +- 0.06 4

No common domains found
Streptomyces alboviridis 386.46 +- 260.58 5 0 2 1 0.04 +- 0.11 5

No common domains found
Streptomyces sp. NRRL S-4 347.31 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF12802 (1/1) MarR family
PF09339 (1/1) IclR helix-turn-helix domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF01614 (1/1) Bacterial transcriptional regulator
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/1) FAD binding domain
Streptomyces sp. CB01249 383.20 +- 125.61 3 0 2 1 0.02 +- 0.02 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. SCA2-2 200.42 +- 27.08 2 0 0 0 0.02 +- 0.01 2 10

PF00561 (2/2) alpha/beta hydrolase fold
PF12697 (1/2) Alpha/beta hydrolase family
PF11723 (1/2) Homotrimeric ring hydroxylase
PF08386 (1/2) TAP-like protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces griseofuscus 103.06 +- 92.72 5 0 0 0 0.05 +- 0.08 5

No common domains found
Streptomyces qaidamensis 723.30 +- 733.73 3 0 1 1 0.02 +- 0.03 3

No common domains found
Streptomyces sp. SceaMP-e96 165.86 +- 0.00 1 0 1 0 0.02 +- 0.01 1 4

PF07883 (1/1) Cupin domain
PF01872 (1/1) RibD C-terminal domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/1) Acetyltransferase (GNAT) family
Streptomyces sp. NRRL S-1022 82.10 +- 32.52 3 0 2 1 0.05 +- 0.07 3

No common domains found
Streptomyces sp. JV178 520.00 +- 0.00 1 0 0 0 0.03 +- 0.01 1 14

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
Streptomyces sp. ScaeMP-e48 381.00 +- 247.21 3 0 3 1 0.06 +- 0.16 3 1

PF00005 (2/3) ABC transporter
Streptomyces avicenniae 313.18 +- 206.82 2 0 1 1 0.05 +- 0.07 2 10

PF00005 (2/2) ABC transporter
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00717 (1/2) Peptidase S24-like
PF00664 (1/2) ABC transporter transmembrane region
Streptomyces sp. 1331.2 881.25 +- 400.12 3 0 2 3 0.02 +- 0.05 3

No common domains found
Streptomyces albidoflavus 540.57 +- 0.00 1 0 1 0 0.07 +- 0.06 1 28

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces xinghaiensis S187 650.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 9

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF13649 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF05193 (1/1) Peptidase M16 inactive domain
PF04989 (1/1) Cephalosporin hydroxylase
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF00805 (1/1) Pentapeptide repeats (8 copies)
PF00675 (1/1) Insulinase (Peptidase family M16)
Streptomyces sp. 61 728.90 +- 670.15 4 0 2 1 0.01 +- 0.02 4 4

TIGR01733 (2/4) amino acid adenylation domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
Streptomyces sp. WAC07149 910.59 +- 0.00 1 0 1 0 0.01 +- 0.01 1 11

TIGR00414 (1/1) serine--tRNA ligase
PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13546 (1/1) DDE superfamily endonuclease
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF02403 (1/1) Seryl-tRNA synthetase N-terminal domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00587 (1/1) tRNA synthetase class II core domain (G, H, P, S and T)
PF00005 (1/1) ABC transporter
Streptomyces sp. CB02414 187.82 +- 0.00 1 0 0 0 0.07 +- 0.22 1 12

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13280 (1/1) WYL domain
PF08279 (1/1) HTH domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces sp. CdTB01 394.49 +- 270.04 6 0 2 1 0.05 +- 0.16 6

No common domains found
Streptomyces sp. E1N211 187.53 +- 156.47 2 0 2 1 0.07 +- 0.06 2 22

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18130 (1/2) ATP-grasp N-terminal domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13471 (1/2) Transglutaminase-like superfamily
PF13462 (1/2) Thioredoxin
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12730 (1/2) ABC-2 family transporter protein
PF09587 (1/2) Bacterial capsule synthesis protein PGA_cap
PF08239 (1/2) Bacterial SH3 domain
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF07681 (1/2) DoxX
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03771 (1/2) Domain of unknown function (DUF317)
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01638 (1/2) HxlR-like helix-turn-helix
PF01061 (1/2) ABC-2 type transporter
PF00733 (1/2) Asparagine synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces sp. FxanaC1 262.50 +- 0.00 1 0 1 1 0.05 +- 0.07 1 12

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
PF10025 (1/1) Uncharacterized conserved protein (DUF2267)
PF08281 (1/1) Sigma-70, region 4
PF07690 (1/1) Major Facilitator Superfamily
PF04542 (1/1) Sigma-70 region 2
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF01833 (1/1) IPT/TIG domain
PF00355 (1/1) Rieske [2Fe-2S] domain
PF00326 (1/1) Prolyl oligopeptidase family
PF00067 (1/1) Cytochrome P450
Streptomyces albidoflavus 427.23 +- 0.00 1 0 1 1 0.07 +- 0.08 1 12

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/1) AAA ATPase domain
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter
Streptomyces decoyicus 241.43 +- 18.57 2 0 0 0 0.01 +- 0.01 2 7

PF12833 (1/2) Helix-turn-helix domain
PF09848 (1/2) Uncharacterized conserved protein (DUF2075)
PF07733 (1/2) Bacterial DNA polymerase III alpha NTPase domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF07045 (1/2) Domain of unknown function (DUF1330)
PF02311 (1/2) AraC-like ligand binding domain
PF00931 (1/2) NB-ARC domain
Streptomyces albulus PD-1 636.93 +- 709.20 6 0 3 1 0.02 +- 0.06 6

No common domains found
Streptomyces acidiscabies 185.15 +- 130.00 2 0 0 0 0.09 +- 0.21 2 25

PF07690 (2/2) Major Facilitator Superfamily
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF12802 (1/2) MarR family
PF10901 (1/2) Protein of unknown function (DUF2690)
PF08443 (1/2) RimK-like ATP-grasp domain
PF05726 (1/2) Pirin C-terminal cupin domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02678 (1/2) Pirin
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00664 (1/2) ABC transporter transmembrane region
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00089 (1/2) Trypsin
PF00005 (1/2) ABC transporter
Streptomyces sp. M56 840.29 +- 1266.40 5 0 1 0 0.05 +- 0.16 5

No common domains found
Streptomyces sp. LHW50302 336.18 +- 217.79 3 0 2 1 0.05 +- 0.19 3

No common domains found
Streptomyces sp. TN58 90.43 +- 0.00 1 0 0 0 0.04 +- 0.05 1 6

PF14903 (1/1) WG containing repeat
PF10042 (1/1) Uncharacterized conserved protein (DUF2278)
PF06983 (1/1) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (1/1) ABC 3 transport family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00005 (1/1) ABC transporter
Streptomyces lydicus 224.68 +- 111.74 5 0 1 1 0.03 +- 0.05 5 1

PF00067 (3/5) Cytochrome P450
Streptomyces sp. GSSD-12 406.87 +- 254.42 6 0 1 3 0.04 +- 0.14 6 1

PF00733 (3/6) Asparagine synthase
Streptomyces sp. 142MFCol3.1 337.93 +- 326.96 8 0 0 1 0.04 +- 0.13 8

No common domains found
Streptomyces xiaopingdaonensis 179.31 +- 0.00 1 0 0 0 0.04 +- 0.04 1 6

PF07702 (1/1) UTRA domain
PF04672 (1/1) S-adenosyl methyltransferase
PF03747 (1/1) ADP-ribosylglycohydrolase
PF02133 (1/1) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
Streptomyces eurocidicus 607.20 +- 324.93 2 0 2 1 0.04 +- 0.09 2 25

PF00005 (2/2) ABC transporter
TIGR03892 (1/2) thiazolylpeptide-type bacteriocin precursor
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/2) amidohydrolase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13622 (1/2) Thioesterase-like superfamily
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF07690 (1/2) Major Facilitator Superfamily
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (1/2) Peptidase family M20/M25/M40
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00301 (1/2) Rubredoxin
PF00296 (1/2) Luciferase-like monooxygenase
PF00067 (1/2) Cytochrome P450
Streptomyces sp. TLI_185 163.38 +- 131.83 5 0 3 1 0.06 +- 0.08 5

No common domains found
Streptomyces griseus subsp. griseus 108.33 +- 0.00 1 0 1 0 0.09 +- 0.14 1 11

PF13796 (1/1) Putative sensor
PF07730 (1/1) Histidine kinase
PF03551 (1/1) Transcriptional regulator PadR-like family
PF03372 (1/1) Endonuclease/Exonuclease/phosphatase family
PF02518 (1/1) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (1/1) D-alanyl-D-alanine carboxypeptidase
PF00672 (1/1) HAMP domain
PF00512 (1/1) His Kinase A (phospho-acceptor) domain
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
Streptomyces rimosus subsp. paromomycinus 62.81 +- 29.94 3 0 3 0 0.06 +- 0.09 3

No common domains found
Streptomyces sp. AA0539 260.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 4

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (1/1) Carbamoyltransferase C-terminus
PF04055 (1/1) Radical SAM superfamily
PF02543 (1/1) Carbamoyltransferase N-terminus
Streptomyces sp. SM5 106.48 +- 51.19 2 0 0 1 0.06 +- 0.01 2 11

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13649 (1/2) Methyltransferase domain
PF13407 (1/2) Periplasmic binding protein domain
PF07702 (1/2) UTRA domain
PF07690 (1/2) Major Facilitator Superfamily
PF05025 (1/2) RbsD / FucU transport protein family
PF04055 (1/2) Radical SAM superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter
Streptomyces albidoflavus 737.28 +- 453.48 2 0 2 1 0.06 +- 0.06 2 39

PF00005 (2/2) ABC transporter
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13191 (1/2) AAA ATPase domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03704 (1/2) Bacterial transcriptional activator domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01497 (1/2) Periplasmic binding protein
PF01061 (1/2) ABC-2 type transporter
PF01032 (1/2) FecCD transport family
PF00881 (1/2) Nitroreductase family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
Streptomyces sp. NRRL F-5122 240.80 +- 0.00 1 0 0 0 0.02 +- 0.02 1 4

PF13365 (1/1) Trypsin-like peptidase domain
PF07721 (1/1) Tetratricopeptide repeat
PF00400 (1/1) WD domain, G-beta repeat
PF00248 (1/1) Aldo/keto reductase family
Streptomyces graminilatus 48.38 +- 0.00 1 0 0 1 0.06 +- 0.08 1 5

TIGR04187 (1/1) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (1/1) putative ATP-grasp target RiPP
PF14404 (1/1) Ribosomally synthesized peptide in Streptomyces species
PF04672 (1/1) S-adenosyl methyltransferase
PF00583 (1/1) Acetyltransferase (GNAT) family
Streptomyces alfalfae 357.43 +- 192.34 4 0 2 2 0.03 +- 0.11 4 4

PF07690 (3/4) Major Facilitator Superfamily
PF04055 (2/4) Radical SAM superfamily
PF02310 (2/4) B12 binding domain
PF00326 (2/4) Prolyl oligopeptidase family
Streptomyces violaceoruber 308.48 +- 0.00 1 0 1 1 0.04 +- 0.04 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces sp. OK885 86.67 +- 0.00 1 0 0 0 0.09 +- 0.11 1 10

TIGR01413 (1/1) Dyp-type peroxidase family
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (1/1) Tetracyclin repressor-like, C-terminal domain
PF14559 (1/1) Tetratricopeptide repeat
PF14224 (1/1) Domain of unknown function (DUF4331)
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF00925 (1/1) GTP cyclohydrolase II
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces yerevanensis 210.54 +- 112.09 4 0 1 0 0.06 +- 0.10 4 2

PF02826 (2/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00005 (2/4) ABC transporter
Streptomyces sp. NRRL S-325 461.67 +- 439.77 4 0 1 2 0.04 +- 0.05 4 1

PF04055 (2/4) Radical SAM superfamily
Streptomyces badius 421.07 +- 325.46 3 0 1 1 0.02 +- 0.03 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. CMB-StM0423 189.18 +- 50.11 3 0 1 0 0.06 +- 0.09 3 1

PF01546 (2/3) Peptidase family M20/M25/M40
Streptomyces rimosus subsp. rimosus 36.86 +- 0.00 1 0 0 0 0.05 +- 0.00 1 3

PF12833 (1/1) Helix-turn-helix domain
PF02311 (1/1) AraC-like ligand binding domain
PF00150 (1/1) Cellulase (glycosyl hydrolase family 5)
Streptomyces sp. TLI_105 295.69 +- 224.31 2 0 0 0 0.03 +- 0.09 2 18

TIGR01549 (1/2) HAD hydrolase, family IA, variant 1
TIGR01249 (1/2) prolyl aminopeptidase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF07690 (1/2) Major Facilitator Superfamily
PF06821 (1/2) Serine hydrolase
PF06245 (1/2) Protein of unknown function (DUF1015)
PF04389 (1/2) Peptidase family M28
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02225 (1/2) PA domain
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
Streptomyces sp. MOE7 289.34 +- 148.57 4 0 2 1 0.04 +- 0.05 4 1

PF00005 (2/4) ABC transporter
Streptomyces sp. NRRL B-1347 237.81 +- 165.66 5 0 2 2 0.04 +- 0.07 5

No common domains found
Streptomyces sp. NRRL S-118 671.67 +- 498.33 2 0 2 1 0.01 +- 0.00 2 20

TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF14805 (1/2) Tetrahydrodipicolinate N-succinyltransferase N-terminal
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF14099 (1/2) Polysaccharide lyase
PF13537 (1/2) Glutamine amidotransferase domain
PF13535 (1/2) ATP-grasp domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF08241 (1/2) Methyltransferase domain
PF05199 (1/2) GMC oxidoreductase
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00892 (1/2) EamA-like transporter family
PF00754 (1/2) F5/8 type C domain
PF00733 (1/2) Asparagine synthase
PF00732 (1/2) GMC oxidoreductase
PF00278 (1/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00155 (1/2) Aminotransferase class I and II
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00082 (1/2) Subtilase family
Streptomyces sp. CB02923 355.34 +- 324.66 3 0 3 1 0.02 +- 0.04 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces sp. WAC04657 279.00 +- 280.87 3 0 1 0 0.04 +- 0.13 3

No common domains found
Streptomyces rimosus subsp. rimosus 54.36 +- 10.14 2 0 1 1 0.05 +- 0.02 2 5

PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00067 (1/2) Cytochrome P450
Streptomyces sp. Termitarium-T10T-6 1020.07 +- 621.75 2 0 2 2 0.04 +- 0.06 2 12

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF08877 (1/2) MepB protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
Streptomyces sp. BK239 222.66 +- 0.00 1 0 0 0 0.08 +- 0.06 1 5

TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF03814 (1/1) Potassium-transporting ATPase A subunit
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00331 (1/1) Glycosyl hydrolase family 10
Streptomyces viridochromogenes 1173.90 +- 495.52 4 0 2 1 0.01 +- 0.00 4 3

PF13378 (2/4) Enolase C-terminal domain-like
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00005 (2/4) ABC transporter
Streptomyces sp. F-3 567.27 +- 0.00 1 0 1 1 0.02 +- 0.02 1 9

TIGR04353 (1/1) PqqD family protein, HPr-rel-A system
PF13646 (1/1) HEAT repeats
PF13471 (1/1) Transglutaminase-like superfamily
PF13411 (1/1) MerR HTH family regulatory protein
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces coelicoflavus 436.50 +- 369.53 4 0 1 0 0.03 +- 0.04 4 3

PF07690 (3/4) Major Facilitator Superfamily
PF00682 (2/4) HMGL-like
PF00180 (2/4) Isocitrate/isopropylmalate dehydrogenase
Streptomyces sp. E5N91 44.57 +- 0.00 1 0 0 0 0.07 +- 0.03 1 5

PF07690 (1/1) Major Facilitator Superfamily
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain
PF00171 (1/1) Aldehyde dehydrogenase family
Streptomyces sp. NRRL S-31 153.93 +- 34.10 3 0 2 2 0.04 +- 0.05 3

No common domains found
Streptomyces avermitilis 268.13 +- 175.76 6 0 2 0 0.04 +- 0.07 6 1

PF07690 (4/6) Major Facilitator Superfamily
Streptomyces vitaminophilus DSM 41686 23.45 +- 0.00 1 0 0 0 0.09 +- 0.07 1 3

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (1/1) Methyltransferase domain
PF00753 (1/1) Metallo-beta-lactamase superfamily
Streptomyces malaysiense 96.75 +- 0.00 1 0 0 0 0.02 +- 0.02 1 3

PF05544 (1/1) Proline racemase
PF05195 (1/1) Aminopeptidase P, N-terminal domain
PF00557 (1/1) Metallopeptidase family M24
Streptomyces sp. URHA0041 234.00 +- 0.00 1 0 0 0 0.04 +- 0.05 1 4

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF08533 (1/1) Beta-galactosidase C-terminal domain
PF01229 (1/1) Glycosyl hydrolases family 39
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
Streptomyces sulphureus DSM 40104 201.72 +- 154.65 5 0 2 1 0.04 +- 0.09 5

No common domains found
Streptomyces sp. NRRL WC-3702 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. 2112.5 190.93 +- 110.16 3 0 0 0 0.04 +- 0.05 3

No common domains found
Streptomyces sp. CNT372 129.00 +- 0.00 1 0 0 0 0.09 +- 0.25 1 8

PF17914 (1/1) HopA1 effector protein family
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces lividans TK24 181.01 +- 0.00 1 0 1 1 0.06 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces sp. CNZ301 450.69 +- 541.09 5 0 2 0 0.05 +- 0.08 5

No common domains found
Streptomyces rubrogriseus 539.62 +- 0.00 1 0 1 1 0.04 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces indicus 774.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR01443 (1/1) intein C-terminal splicing region
PF14436 (1/1) Bacterial EndoU nuclease
PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF07591 (1/1) Pretoxin HINT domain
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces albidoflavus 161.25 +- 0.00 1 0 0 0 0.01 +- 0.01 1 4

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces griseocarneus 2612.92 +- 1301.12 3 0 2 1 0.01 +- 0.01 3 3

PF07690 (2/3) Major Facilitator Superfamily
PF00067 (2/3) Cytochrome P450
PF00005 (2/3) ABC transporter
Streptomyces sp. CB01201 224.05 +- 0.00 1 0 0 1 0.01 +- 0.02 1 5

PF08445 (1/1) FR47-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF05076 (1/1) Suppressor of fused protein (SUFU)
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
Streptomyces resistomycificus 572.85 +- 77.15 2 0 0 0 0.04 +- 0.11 2 30

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
TIGR03567 (1/2) FMN reductase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01484 (1/2) HAD hydrolase, family IIB
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain
PF14559 (1/2) Tetratricopeptide repeat
PF13535 (1/2) ATP-grasp domain
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (1/2) Tetratricopeptide repeat
PF13424 (1/2) Tetratricopeptide repeat
PF09334 (1/2) tRNA synthetases class I (M)
PF08282 (1/2) haloacid dehalogenase-like hydrolase
PF08281 (1/2) Sigma-70, region 4
PF07883 (1/2) Cupin domain
PF04542 (1/2) Sigma-70 region 2
PF03358 (1/2) NADPH-dependent FMN reductase
PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (1/2) MGS-like domain
PF01808 (1/2) AICARFT/IMPCHase bienzyme
PF01613 (1/2) Flavin reductase like domain
PF01259 (1/2) SAICAR synthetase
PF00709 (1/2) Adenylosuccinate synthetase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. WM6368 216.67 +- 0.00 1 0 0 0 0.01 +- 0.01 1 6

PF13459 (1/1) 4Fe-4S single cluster domain
PF10589 (1/1) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/1) TAP-like protein
PF03640 (1/1) Secreted repeat of unknown function
PF01512 (1/1) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces sp. NRRL WC-3549 118.18 +- 0.00 1 0 0 0 0.03 +- 0.05 1 4

PF01738 (1/1) Dienelactone hydrolase family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00156 (1/1) Phosphoribosyl transferase domain
PF00005 (1/1) ABC transporter
Streptomyces formicae 598.31 +- 470.74 5 0 2 4 0.02 +- 0.04 5 1

PF04055 (3/5) Radical SAM superfamily
Streptomyces abyssalis 114.67 +- 0.00 1 0 0 0 0.03 +- 0.03 1 6

PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain
Streptomyces katrae 200.91 +- 0.00 1 0 1 0 0.07 +- 0.16 1 12

PF13641 (1/1) Glycosyltransferase like family 2
PF10823 (1/1) Protein of unknown function (DUF2568)
PF09335 (1/1) SNARE associated Golgi protein
PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (1/1) LysE type translocator
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00925 (1/1) GTP cyclohydrolase II
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00400 (1/1) WD domain, G-beta repeat
PF00067 (1/1) Cytochrome P450
Streptomyces griseus subsp. rhodochrous 30.35 +- 0.00 1 0 0 0 0.07 +- 0.06 1 6

PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF08386 (1/1) TAP-like protein
PF07691 (1/1) PA14 domain
PF02837 (1/1) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (1/1) Glycosyl hydrolases family 2
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces sp. Ag82_G6-1 582.26 +- 501.25 4 0 2 2 0.04 +- 0.08 4 2

PF00005 (3/4) ABC transporter
PF01061 (2/4) ABC-2 type transporter
Streptomyces sp. H-KF8 230.36 +- 0.00 1 0 1 0 0.07 +- 0.18 1 22

TIGR01733 (1/1) amino acid adenylation domain
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13560 (1/1) Helix-turn-helix domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF06368 (1/1) Methylaspartate mutase E chain (MutE)
PF03621 (1/1) MbtH-like protein
PF02784 (1/1) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (1/1) B12 binding domain
PF02222 (1/1) ATP-grasp domain
PF01645 (1/1) Conserved region in glutamate synthase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00152 (1/1) tRNA synthetases class II (D, K and N)
Streptomyces albus subsp. albus 339.13 +- 0.00 1 0 1 1 0.03 +- 0.03 1 6

PF05147 (1/1) Lanthionine synthetase C-like protein
PF04672 (1/1) S-adenosyl methyltransferase
PF00664 (1/1) ABC transporter transmembrane region
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL WC-3703 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces rimosus subsp. rimosus 42.62 +- 5.76 2 0 1 1 0.06 +- 0.00 2 6

PF13471 (1/2) Transglutaminase-like superfamily
PF12833 (1/2) Helix-turn-helix domain
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02311 (1/2) AraC-like ligand binding domain
PF00733 (1/2) Asparagine synthase
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
Streptomyces xinghaiensis 189.09 +- 0.00 1 0 1 0 0.04 +- 0.10 1 25

TIGR01762 (1/1) chlorinating enzyme
TIGR01733 (1/1) amino acid adenylation domain
TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
TIGR01444 (1/1) methyltransferase, FkbM family
TIGR00843 (1/1) benzoate transporter
PF16990 (1/1) Carbohydrate binding module (family 35)
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF13454 (1/1) FAD-NAD(P)-binding
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07691 (1/1) PA14 domain
PF06439 (1/1) Domain of Unknown Function (DUF1080)
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (1/1) Methyltransferase FkbM domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF03594 (1/1) Benzoate membrane transport protein
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01116 (1/1) Fructose-bisphosphate aldolase class-II
PF00975 (1/1) Thioesterase domain
PF00892 (1/1) EamA-like transporter family
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
Streptomyces sp. Root63 227.04 +- 0.00 1 0 0 0 0.02 +- 0.01 1 7

TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/1) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/1) YbaB/EbfC DNA-binding family
Streptomyces scabiei 1290.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 9

PF16353 (1/1) Domain of unknown function(DUF4981)
PF14310 (1/1) Fibronectin type III-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF02929 (1/1) Beta galactosidase small chain
PF02837 (1/1) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/1) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (1/1) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00232 (1/1) Glycosyl hydrolase family 1
Streptomyces rimosus 206.94 +- 111.08 5 0 2 1 0.03 +- 0.02 5

No common domains found
Streptomyces spongiicola 1341.60 +- 0.00 1 0 1 1 0.01 +- 0.01 1 7

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
Streptomyces chartreusis NRRL 3882 278.92 +- 237.08 2 0 1 0 0.06 +- 0.14 2 12

TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF11239 (1/2) Protein of unknown function (DUF3040)
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04203 (1/2) Sortase domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02610 (1/2) L-arabinose isomerase
PF00999 (1/2) Sodium/hydrogen exchanger family
PF00975 (1/2) Thioesterase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
Streptomyces zinciresistens K42 272.63 +- 116.63 2 0 0 0 0.03 +- 0.05 2 22

TIGR01554 (1/2) phage major capsid protein, HK97 family
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR01537 (1/2) phage portal protein, HK97 family
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (1/2) Helix-turn-helix domain
PF13378 (1/2) Enolase C-terminal domain-like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/2) FCD domain
PF05065 (1/2) Phage capsid family
PF04860 (1/2) Phage portal protein
PF04586 (1/2) Caudovirus prohead serine protease
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01844 (1/2) HNH endonuclease
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01081 (1/2) KDPG and KHG aldolase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
Streptomyces rimosus subsp. rimosus 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. QL37 351.82 +- 0.00 1 0 0 0 0.02 +- 0.02 1 6

PF17996 (1/1) Carbohydrate esterase 2 N-terminal
PF17479 (1/1) Protein of unknown function (DUF3048) C-terminal domain
PF13472 (1/1) GDSL-like Lipase/Acylhydrolase family
PF11258 (1/1) Protein of unknown function (DUF3048) N-terminal domain
PF05988 (1/1) Bacterial protein of unknown function (DUF899)
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
Streptomyces albidoflavus 229.59 +- 166.98 6 0 3 1 0.06 +- 0.09 6

No common domains found
Streptomyces tsukubensis NRRL18488 212.98 +- 0.00 1 0 0 1 0.03 +- 0.01 1 10

TIGR04469 (1/1) CGA synthase-related protein
TIGR04468 (1/1) arginine 2,3-aminomutase
TIGR04467 (1/1) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (1/1) cytosylglucuronate decarboxylase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF08241 (1/1) Methyltransferase domain
PF05014 (1/1) Nucleoside 2-deoxyribosyltransferase
PF04055 (1/1) Radical SAM superfamily
PF01433 (1/1) Peptidase family M1 domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
Streptomyces sp. 94 655.84 +- 540.10 3 0 1 0 0.04 +- 0.06 3 2

PF07690 (2/3) Major Facilitator Superfamily
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
Streptomyces sp. WM6391 61.92 +- 0.00 1 0 0 0 0.05 +- 0.07 1 4

PF11303 (1/1) Protein of unknown function (DUF3105)
PF09335 (1/1) SNARE associated Golgi protein
PF02388 (1/1) FemAB family
PF00507 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
Streptomyces somaliensis DSM 40738 258.00 +- 0.00 1 0 1 0 0.01 +- 0.00 1 2

PF00296 (1/1) Luciferase-like monooxygenase
PF00069 (1/1) Protein kinase domain
Streptomyces rochei 67.89 +- 0.00 1 0 0 0 0.07 +- 0.07 1 7

PF13671 (1/1) AAA domain
PF13649 (1/1) Methyltransferase domain
PF01427 (1/1) D-ala-D-ala dipeptidase
PF01425 (1/1) Amidase
PF00293 (1/1) NUDIX domain
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces tirandamycinicus 2408.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces griseus 94.29 +- 0.00 1 0 0 0 0.10 +- 0.22 1 10

TIGR00589 (1/1) methylated-DNA--[protein]-cysteine S-methyltransferase
PF13532 (1/1) 2OG-Fe(II) oxygenase superfamily
PF12728 (1/1) Helix-turn-helix domain
PF12307 (1/1) Protein of unknown function (DUF3631)
PF10935 (1/1) Protein of unknown function (DUF2637)
PF09250 (1/1) Bifunctional DNA primase/polymerase, N-terminal
PF04461 (1/1) Protein of unknown function (DUF520)
PF01035 (1/1) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00589 (1/1) Phage integrase family
PF00145 (1/1) C-5 cytosine-specific DNA methylase
Streptomyces sp. WAC08241 239.30 +- 0.00 1 0 0 0 0.03 +- 0.05 1 20

TIGR02124 (1/1) hydrogenase expression/formation protein HypE
TIGR01891 (1/1) amidohydrolase
TIGR00709 (1/1) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/1) carbamoyltransferase HypF
PF17788 (1/1) HypF Kae1-like domain
PF13671 (1/1) AAA domain
PF13535 (1/1) ATP-grasp domain
PF12680 (1/1) SnoaL-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF07503 (1/1) HypF finger
PF05977 (1/1) Transmembrane secretion effector
PF02769 (1/1) AIR synthase related protein, C-terminal domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01300 (1/1) Telomere recombination
PF00857 (1/1) Isochorismatase family
PF00708 (1/1) Acylphosphatase
PF00586 (1/1) AIR synthase related protein, N-terminal domain
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00202 (1/1) Aminotransferase class-III
PF00155 (1/1) Aminotransferase class I and II
Streptomyces lydicus 397.18 +- 430.60 6 0 1 1 0.03 +- 0.04 6

No common domains found
Streptomyces yangpuensis 2686.03 +- 3671.47 3 0 2 1 0.03 +- 0.08 3

No common domains found
Streptomyces sp. 13-12-16 302.73 +- 109.23 2 0 0 0 0.02 +- 0.02 2 18

TIGR02103 (1/2) alpha-1,6-glucosidases, pullulanase-type
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF17967 (1/2) Pullulanase N2 domain
PF11852 (1/2) Domain of unknown function (DUF3372)
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF03881 (1/2) Fructosamine kinase
PF03714 (1/2) Bacterial pullanase-associated domain
PF02922 (1/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (1/2) Alpha amylase, C-terminal all-beta domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01356 (1/2) Alpha amylase inhibitor
PF00892 (1/2) EamA-like transporter family
PF00686 (1/2) Starch binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00128 (1/2) Alpha amylase, catalytic domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. NRRL F-5126 680.41 +- 524.06 3 0 0 1 0.01 +- 0.02 3

No common domains found
Streptomyces aurantiacus 175.19 +- 0.00 1 0 0 0 0.06 +- 0.09 1 14

TIGR01207 (1/1) glucose-1-phosphate thymidylyltransferase
TIGR01181 (1/1) dTDP-glucose 4,6-dehydratase
PF16363 (1/1) GDP-mannose 4,6 dehydratase
PF12833 (1/1) Helix-turn-helix domain
PF07690 (1/1) Major Facilitator Superfamily
PF05141 (1/1) Pyoverdine/dityrosine biosynthesis protein
PF03559 (1/1) NDP-hexose 2,3-dehydratase
PF01965 (1/1) DJ-1/PfpI family
PF01370 (1/1) NAD dependent epimerase/dehydratase family
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00908 (1/1) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00483 (1/1) Nucleotidyl transferase
PF00067 (1/1) Cytochrome P450
Streptomyces pristinaespiralis 206.93 +- 168.14 5 0 0 1 0.04 +- 0.03 5

No common domains found
Streptomyces aureocirculatus 58.74 +- 21.88 2 0 0 0 0.07 +- 0.11 2 6

PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF03483 (1/2) B3/4 domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01810 (1/2) LysE type translocator
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00246 (1/2) Zinc carboxypeptidase
Streptomyces rimosus subsp. rimosus 73.80 +- 12.86 2 0 1 1 0.06 +- 0.06 2 12

PF14158 (1/2) YndJ-like protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13492 (1/2) GAF domain
PF13471 (1/2) Transglutaminase-like superfamily
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00733 (1/2) Asparagine synthase
PF00149 (1/2) Calcineurin-like phosphoesterase
Streptomyces bingchenggensis BCW-1 326.87 +- 292.66 7 0 5 2 0.06 +- 0.15 7

No common domains found
Streptomyces clavuligerus 180.37 +- 192.21 3 0 2 0 0.03 +- 0.06 3 2

TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13419 (2/3) Haloacid dehalogenase-like hydrolase
Streptomyces albus subsp. albus 330.53 +- 436.11 4 0 2 1 0.03 +- 0.03 4 4

TIGR03945 (2/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/4) 2,3-diaminopropionate biosynthesis protein SbnB
PF02423 (2/4) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme
Streptomyces sp. GZWMJZ-114 110.57 +- 0.00 1 0 0 0 0.04 +- 0.04 1 4

PF13517 (1/1) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF05099 (1/1) Tellurite resistance protein TerB
PF00106 (1/1) short chain dehydrogenase
PF00089 (1/1) Trypsin
Streptomyces griseoluteus 397.05 +- 424.35 3 0 2 2 0.04 +- 0.05 3

No common domains found
Streptomyces himastatinicus ATCC 53653 135.90 +- 63.64 3 0 1 1 0.06 +- 0.08 3 2

PF00583 (2/3) Acetyltransferase (GNAT) family
PF00171 (2/3) Aldehyde dehydrogenase family
Streptomyces sp. NRRL F-5635 75.51 +- 0.00 1 0 0 0 0.05 +- 0.03 1 10

TIGR00745 (1/1) 2-dehydropantoate 2-reductase
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13412 (1/1) Winged helix-turn-helix DNA-binding
PF13404 (1/1) AsnC-type helix-turn-helix domain
PF08546 (1/1) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF02558 (1/1) Ketopantoate reductase PanE/ApbA
PF01546 (1/1) Peptidase family M20/M25/M40
PF01522 (1/1) Polysaccharide deacetylase
PF01037 (1/1) Lrp/AsnC ligand binding domain
Streptomyces albireticuli 645.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 4

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00733 (1/1) Asparagine synthase
Streptomyces gilvigriseus 86.00 +- 0.00 1 0 0 0 0.02 +- 0.02 1 3

PF18029 (1/1) Glyoxalase-like domain
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF01636 (1/1) Phosphotransferase enzyme family
Streptomyces turgidiscabies Car8 245.82 +- 85.25 6 0 1 1 0.04 +- 0.04 6 1

PF07690 (3/6) Major Facilitator Superfamily
Streptomyces avellaneus 1872.00 +- 1560.00 2 0 1 1 0.01 +- 0.01 2 14

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02462 (1/2) pyranose oxidase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (1/2) Winged helix DNA-binding domain
PF12698 (1/2) ABC-2 family transporter protein
PF07690 (1/2) Major Facilitator Superfamily
PF05199 (1/2) GMC oxidoreductase
PF03928 (1/2) Haem-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/2) Nitroreductase family
PF00732 (1/2) GMC oxidoreductase
PF00005 (1/2) ABC transporter
Streptomyces pluripotens 650.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 6

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces sp. Root1304 470.80 +- 499.46 3 0 1 1 0.03 +- 0.03 3

No common domains found
Streptomyces sp. 2132.2 429.97 +- 558.69 4 0 1 0 0.04 +- 0.14 4 3

PF18130 (2/4) ATP-grasp N-terminal domain
PF13535 (2/4) ATP-grasp domain
PF07690 (2/4) Major Facilitator Superfamily
Streptomyces ochraceiscleroticus 216.67 +- 0.00 1 0 0 1 0.01 +- 0.00 1 7

TIGR00268 (1/1) TIGR00268 family protein
PF13620 (1/1) Carboxypeptidase regulatory-like domain
PF09861 (1/1) Lactate racemase N-terminal domain
PF04264 (1/1) YceI-like domain
PF00733 (1/1) Asparagine synthase
PF00731 (1/1) AIR carboxylase
PF00083 (1/1) Sugar (and other) transporter
Streptomyces sp. BvitLS-983 23.64 +- 0.00 1 0 0 0 0.08 +- 0.07 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces rimosus subsp. rimosus 54.36 +- 10.14 2 0 1 1 0.05 +- 0.02 2 5

PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00067 (1/2) Cytochrome P450
Streptomyces sp. NRRL S-350 183.65 +- 124.34 4 0 3 1 0.04 +- 0.03 4

No common domains found
Streptomyces sp. 75 860.00 +- 0.00 1 0 1 0 0.01 +- 0.01 1 20

TIGR02814 (1/1) PfaD family protein
TIGR02813 (1/1) polyketide-type polyunsaturated fatty acid synthase PfaA
PF18328 (1/1) Fatty acid synthase subunit PfaD N-terminal domain
PF16197 (1/1) Ketoacyl-synthetase C-terminal extension
PF14765 (1/1) Polyketide synthase dehydratase
PF12833 (1/1) Helix-turn-helix domain
PF08659 (1/1) KR domain
PF07977 (1/1) FabA-like domain
PF03060 (1/1) Nitronate monooxygenase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02311 (1/1) AraC-like ligand binding domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01593 (1/1) Flavin containing amine oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00698 (1/1) Acyl transferase domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
Streptomyces sp. ScaeMP-e122 290.27 +- 109.67 4 0 2 1 0.05 +- 0.14 4

No common domains found
Streptomyces triticisoli 1806.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 12

PF14759 (1/1) Reductase C-terminal
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/1) IclR helix-turn-helix domain
PF09084 (1/1) NMT1/THI5 like
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF01614 (1/1) Bacterial transcriptional regulator
PF01494 (1/1) FAD binding domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00171 (1/1) Aldehyde dehydrogenase family
PF00111 (1/1) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL B-3253 29.77 +- 0.00 1 0 0 0 0.07 +- 0.02 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces griseoruber 1127.56 +- 595.63 3 0 1 0 0.01 +- 0.01 3

No common domains found
Streptomyces californicus 189.85 +- 0.00 1 0 0 0 0.03 +- 0.02 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces sp. NRRL WC-3618 825.60 +- 0.00 1 0 0 0 0.02 +- 0.03 1 9

PF13333 (1/1) Integrase core domain
PF12146 (1/1) Serine aminopeptidase, S33
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/1) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/1) FAD binding domain
PF00725 (1/1) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/1) Integrase core domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00144 (1/1) Beta-lactamase
Streptomyces sp. OspMP-M45 110.69 +- 13.19 2 0 0 1 0.06 +- 0.05 2 12

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces varsoviensis 642.52 +- 496.13 4 0 4 2 0.02 +- 0.03 4 2

PF00550 (2/4) Phosphopantetheine attachment site
PF00005 (2/4) ABC transporter
Streptomyces antibioticus 469.97 +- 629.91 4 0 1 1 0.06 +- 0.08 4 1

PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
Streptomyces sp. Amel2xE9 292.28 +- 94.72 2 0 2 0 0.07 +- 0.16 2 34

TIGR02144 (1/2) lysine biosynthesis enzyme LysX
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR00761 (1/2) acetylglutamate kinase
PF16864 (1/2) Dimerisation domain
PF13847 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF04389 (1/2) Peptidase family M28
PF03621 (1/2) MbtH-like protein
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01565 (1/2) FAD binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (1/2) O-methyltransferase domain
PF00696 (1/2) Amino acid kinase family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00067 (1/2) Cytochrome P450
Streptomyces mirabilis 330.79 +- 287.77 4 0 2 0 0.03 +- 0.02 4

No common domains found
Streptomyces sp. TP-A0356 189.36 +- 147.27 3 0 2 0 0.02 +- 0.03 3

No common domains found
Streptomyces sp. FR-008 798.98 +- 841.21 3 0 2 1 0.05 +- 0.09 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. NRRL F-5135 339.13 +- 0.00 1 0 0 0 0.03 +- 0.01 1 8

TIGR03249 (1/1) 5-dehydro-4-deoxyglucarate dehydratase
PF14588 (1/1) YjgF/chorismate_mutase-like, putative endoribonuclease
PF09084 (1/1) NMT1/THI5 like
PF01321 (1/1) Creatinase/Prolidase N-terminal domain
PF00701 (1/1) Dihydrodipicolinate synthetase family
PF00557 (1/1) Metallopeptidase family M24
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL S-1896 299.00 +- 91.00 2 0 1 1 0.01 +- 0.02 2 9

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF06628 (1/2) Catalase-related immune-responsive
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF01475 (1/2) Ferric uptake regulator family
PF00248 (1/2) Aldo/keto reductase family
PF00199 (1/2) Catalase
Streptomyces acidiscabies 226.45 +- 163.55 2 0 0 0 0.03 +- 0.02 2 15

TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF18565 (1/2) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (1/2) Domain of unknown function (DUF4982)
PF14310 (1/2) Fibronectin type III-like domain
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01522 (1/2) Polysaccharide deacetylase
PF01081 (1/2) KDPG and KHG aldolase
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00703 (1/2) Glycosyl hydrolases family 2
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00296 (1/2) Luciferase-like monooxygenase
Streptomyces bikiniensis 389.15 +- 255.86 3 0 1 1 0.02 +- 0.04 3

No common domains found
Streptomyces sp. LUP47B 91.42 +- 44.71 3 0 0 0 0.07 +- 0.05 3

No common domains found
Streptomyces sp. NBRC 110611 523.98 +- 729.56 5 0 1 1 0.03 +- 0.09 5

No common domains found
Streptomyces sp. WMMB 322 84.13 +- 0.00 1 0 0 0 0.06 +- 0.07 1 8

PF07690 (1/1) Major Facilitator Superfamily
PF07158 (1/1) Dicarboxylate carrier protein MatC N-terminus
PF03033 (1/1) Glycosyltransferase family 28 N-terminal domain
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (1/1) CoA-transferase family III
PF00932 (1/1) Lamin Tail Domain
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain
Streptomyces sp. NRRL S-87 158.26 +- 101.74 2 0 0 0 0.06 +- 0.09 2 11

TIGR02957 (1/2) RNA polymerase sigma-70 factor, TIGR02957 family
PF18029 (1/2) Glyoxalase-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04235 (1/2) Protein of unknown function (DUF418)
PF01965 (1/2) DJ-1/PfpI family
PF01738 (1/2) Dienelactone hydrolase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00156 (1/2) Phosphoribosyl transferase domain
Streptomyces azureus 30.35 +- 0.00 1 0 0 0 0.07 +- 0.06 1 2

PF02515 (1/1) CoA-transferase family III
PF00583 (1/1) Acetyltransferase (GNAT) family
Streptomyces californicus 136.44 +- 57.06 2 0 0 0 0.04 +- 0.03 2 14

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07690 (1/2) Major Facilitator Superfamily
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00106 (1/2) short chain dehydrogenase
Streptomyces rhizosphaericus 294.86 +- 0.00 1 0 0 0 0.01 +- 0.00 1 3

PF02838 (1/1) Glycosyl hydrolase family 20, domain 2
PF00754 (1/1) F5/8 type C domain
PF00728 (1/1) Glycosyl hydrolase family 20, catalytic domain
Streptomyces olivaceus 183.75 +- 189.95 3 0 1 1 0.05 +- 0.08 3 1

PF00501 (2/3) AMP-binding enzyme
Streptomyces sp. Root66D1 704.54 +- 188.54 2 0 1 1 0.01 +- 0.00 2 12

PF13661 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13640 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13577 (1/2) SnoaL-like domain
PF08291 (1/2) Peptidase M15
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01471 (1/2) Putative peptidoglycan binding domain
PF00899 (1/2) ThiF family
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
Streptomyces albidoflavus 175.38 +- 0.00 1 0 0 0 0.07 +- 0.11 1 15

TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (1/1) Domain of unknown function (DUF4380)
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13407 (1/1) Periplasmic binding protein domain
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF01081 (1/1) KDPG and KHG aldolase
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00107 (1/1) Zinc-binding dehydrogenase
PF00005 (1/1) ABC transporter
Streptomyces sp. CNS335 346.67 +- 173.33 2 0 1 0 0.01 +- 0.01 2 18

TIGR01733 (1/2) amino acid adenylation domain
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13545 (1/2) Crp-like helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00326 (1/2) Prolyl oligopeptidase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00027 (1/2) Cyclic nucleotide-binding domain
Streptomyces geranii 287.87 +- 288.65 9 0 1 0 0.04 +- 0.05 9

No common domains found
Streptomyces sp. NRRL S-646 2228.54 +- 1567.40 3 0 1 0 0.02 +- 0.05 3 3

PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
Streptomyces sp. NRRL WC-3774 432.53 +- 241.48 3 0 0 0 0.01 +- 0.01 3 4

PF09339 (2/3) IclR helix-turn-helix domain
PF01614 (2/3) Bacterial transcriptional regulator
PF00175 (2/3) Oxidoreductase NAD-binding domain
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces brasiliensis 173.48 +- 0.00 1 0 0 0 0.03 +- 0.02 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces sp. EN16 136.40 +- 73.29 5 0 1 0 0.06 +- 0.06 5

No common domains found
Streptomyces lydicus 105.22 +- 11.41 2 0 1 1 0.06 +- 0.08 2 17

PF07690 (2/2) Major Facilitator Superfamily
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF10025 (1/2) Uncharacterized conserved protein (DUF2267)
PF08281 (1/2) Sigma-70, region 4
PF07681 (1/2) DoxX
PF04542 (1/2) Sigma-70 region 2
PF04055 (1/2) Radical SAM superfamily
PF02515 (1/2) CoA-transferase family III
PF02310 (1/2) B12 binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00326 (1/2) Prolyl oligopeptidase family
PF00067 (1/2) Cytochrome P450
Streptomyces populi 359.11 +- 279.44 2 0 0 0 0.04 +- 0.15 2 17

PF11271 (1/2) Porin PorA
PF10502 (1/2) Signal peptidase, peptidase S26
PF10145 (1/2) Phage-related minor tail protein
PF06199 (1/2) Phage tail tube protein
PF04860 (1/2) Phage portal protein
PF04586 (1/2) Caudovirus prohead serine protease
PF03704 (1/2) Bacterial transcriptional activator domain
PF03237 (1/2) Terminase-like family
PF02018 (1/2) Carbohydrate binding domain
PF01844 (1/2) HNH endonuclease
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00931 (1/2) NB-ARC domain
PF00899 (1/2) ThiF family
PF00717 (1/2) Peptidase S24-like
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter
Streptomyces sp. OV198 179.81 +- 61.78 4 0 1 0 0.04 +- 0.07 4 1

PF03067 (2/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
Streptomyces viridochromogenes Tue57 69.59 +- 11.88 3 0 0 0 0.05 +- 0.10 3

No common domains found
Streptomyces sp. TSRI0445 504.94 +- 140.06 2 0 1 1 0.02 +- 0.02 2 12

PF00005 (2/2) ABC transporter
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00296 (1/2) Luciferase-like monooxygenase
PF00069 (1/2) Protein kinase domain
Streptomyces milbemycinicus 248.51 +- 229.43 4 0 2 2 0.02 +- 0.02 4 1

PF05147 (2/4) Lanthionine synthetase C-like protein
Streptomyces griseoflavus 167.02 +- 138.44 4 0 1 1 0.04 +- 0.05 4

No common domains found
Streptomyces curacoi 949.55 +- 1479.35 4 0 1 1 0.03 +- 0.07 4

No common domains found
Streptomyces albidoflavus 51.60 +- 0.00 1 0 0 0 0.04 +- 0.03 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces sp. WMMB 322 77.40 +- 0.00 2 0 1 0 0.08 +- 0.17 2 24

TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01686 (1/2) FkbH domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07158 (1/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (1/2) Glycosyltransferase family 28 N-terminal domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (1/2) CoA-transferase family III
PF00975 (1/2) Thioesterase domain
PF00932 (1/2) Lamin Tail Domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
Streptomyces sp. MMG1064 1671.43 +- 0.00 1 0 0 0 0.01 +- 0.01 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces sp. 136MFCol5.1 211.75 +- 108.55 2 0 0 0 0.06 +- 0.16 2 30

TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF17291 (1/2) N-terminal domain of M60-like peptidases
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13402 (1/2) Peptidase M60, enhancin and enhancin-like
PF13378 (1/2) Enolase C-terminal domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF12831 (1/2) FAD dependent oxidoreductase
PF10022 (1/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08124 (1/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF02884 (1/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (1/2) CoA-transferase family III
PF02278 (1/2) Polysaccharide lyase family 8, super-sandwich domain
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01381 (1/2) Helix-turn-helix
PF01380 (1/2) SIS domain
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
Streptomyces sp. DvalAA-43 161.20 +- 98.80 2 0 1 0 0.03 +- 0.04 2 15

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13181 (1/2) Tetratricopeptide repeat
PF07690 (1/2) Major Facilitator Superfamily
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00578 (1/2) AhpC/TSA family
PF00550 (1/2) Phosphopantetheine attachment site
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
Streptomyces viridochromogenes DSM 40736 365.16 +- 190.80 4 0 2 1 0.03 +- 0.04 4 1

PF00005 (2/4) ABC transporter
Streptomyces sp. WAC 06738 336.90 +- 316.88 3 0 0 0 0.03 +- 0.03 3

No common domains found
Streptomyces lydicus 558.54 +- 373.93 3 0 2 1 0.07 +- 0.15 3 3

PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter
Streptomyces sp. 2112.3 296.59 +- 193.16 3 0 1 1 0.05 +- 0.14 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. Ag109_O5-10 173.33 +- 0.00 1 0 0 0 0.02 +- 0.02 1 8

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07702 (1/1) UTRA domain
PF03747 (1/1) ADP-ribosylglycohydrolase
PF02133 (1/1) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00582 (1/1) Universal stress protein family
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
Streptomyces aurantiacus JA 4570 310.73 +- 0.00 1 0 1 1 0.02 +- 0.02 1 8

PF13560 (1/1) Helix-turn-helix domain
PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (1/1) Peptidase family M20/M25/M40
PF01381 (1/1) Helix-turn-helix
PF00733 (1/1) Asparagine synthase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00005 (1/1) ABC transporter
Streptomyces cellostaticus 1092.95 +- 1241.10 3 0 2 0 0.02 +- 0.04 3 1

PF13393 (2/3) Histidyl-tRNA synthetase
Kitasatospora xanthocidica 384.84 +- 203.16 3 0 2 1 0.04 +- 0.06 3

No common domains found
Streptomyces sp. 840.1 143.05 +- 0.00 1 0 1 0 0.06 +- 0.17 1 19

TIGR03026 (1/1) nucleotide sugar dehydrogenase
TIGR01733 (1/1) amino acid adenylation domain
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF13469 (1/1) Sulfotransferase family
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07690 (1/1) Major Facilitator Superfamily
PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (1/1) Malate/L-lactate dehydrogenase
PF01522 (1/1) Polysaccharide deacetylase
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (1/1) Xylose isomerase-like TIM barrel
PF00984 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces sp. DUT11 258.00 +- 0.00 1 0 0 0 0.06 +- 0.04 1 11

PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF12679 (1/1) ABC-2 family transporter protein
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01144 (1/1) Coenzyme A transferase
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/1) short chain dehydrogenase
PF00005 (1/1) ABC transporter
Streptomyces sp. Root1295 283.80 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/1) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/1) YbaB/EbfC DNA-binding family
Streptomyces flaveus 166.54 +- 0.00 1 0 0 0 0.08 +- 0.06 1 17

TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (1/1) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (1/1) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/1) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (1/1) Alpha galactosidase A
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01081 (1/1) KDPG and KHG aldolase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
Streptomyces peucetius subsp. caesius ATCC 27952 108.43 +- 35.18 5 0 1 1 0.05 +- 0.08 5

No common domains found
Streptomyces sp. NBRC 109436 210.91 +- 113.50 4 0 0 0 0.04 +- 0.04 4 1

PF07690 (4/4) Major Facilitator Superfamily
Streptomyces sp. NRRL F-6628 1593.53 +- 0.00 1 0 1 0 0.03 +- 0.02 1 28

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces tateyamensis 455.00 +- 0.00 1 0 1 0 0.04 +- 0.04 1 26

TIGR01733 (1/1) amino acid adenylation domain
PF18563 (1/1) TubC N-terminal docking domain
PF16653 (1/1) Saccharopine dehydrogenase C-terminal domain
PF14518 (1/1) Iron-containing redox enzyme
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF05222 (1/1) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (1/1) Saccharopine dehydrogenase NADP binding domain
PF03417 (1/1) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01266 (1/1) FAD dependent oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (1/1) Cytochrome P450
Streptomyces sp. AmelKG-D3 1337.14 +- 0.00 1 0 1 0 0.02 +- 0.01 1 17

TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR01307 (1/1) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (1/1) ATP-grasp domain
PF13535 (1/1) ATP-grasp domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF13115 (1/1) YtkA-like
PF04389 (1/1) Peptidase family M28
PF02627 (1/1) Carboxymuconolactone decarboxylase family
PF01676 (1/1) Metalloenzyme superfamily
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00664 (1/1) ABC transporter transmembrane region
PF00403 (1/1) Heavy-metal-associated domain
PF00275 (1/1) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/1) Aminotransferase class I and II
PF00122 (1/1) E1-E2 ATPase
PF00117 (1/1) Glutamine amidotransferase class-I
PF00005 (1/1) ABC transporter
Streptomyces sp. CB01635 125.51 +- 74.13 5 0 1 0 0.06 +- 0.10 5

No common domains found
Streptomyces hundungensis 703.64 +- 181.93 3 0 0 0 0.01 +- 0.00 3

No common domains found
Streptomyces sp. ADI96-02 686.34 +- 532.14 4 0 1 1 0.01 +- 0.01 4 1

PF00005 (2/4) ABC transporter
Streptomyces cacaoi subsp. cacaoi 172.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF13649 (1/1) Methyltransferase domain
PF04672 (1/1) S-adenosyl methyltransferase
Streptomyces qinglanensis 5794.29 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter
Streptomyces sp. 57 516.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 10

TIGR04276 (1/1) FxsC C-terminal domain
TIGR04269 (1/1) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (1/1) FXSXX-COOH protein
TIGR04267 (1/1) HEXXH motif domain
PF13676 (1/1) TIR domain
PF13424 (1/1) Tetratricopeptide repeat
PF13374 (1/1) Tetratricopeptide repeat
PF04055 (1/1) Radical SAM superfamily
PF01656 (1/1) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (1/1) NB-ARC domain
Streptomyces sp. 111WW2 264.81 +- 0.00 1 0 1 1 0.04 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces kasugaensis 1328.22 +- 1250.88 3 0 0 0 0.01 +- 0.00 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. Tue 6075 173.33 +- 0.00 1 0 0 0 0.02 +- 0.02 1 8

TIGR00067 (1/1) glutamate racemase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF07478 (1/1) D-ala D-ala ligase C-terminus
PF01820 (1/1) D-ala D-ala ligase N-terminus
PF01177 (1/1) Asp/Glu/Hydantoin racemase
Streptomyces sp. di50b 401.33 +- 0.00 1 0 1 1 0.07 +- 0.23 1 11

PF13649 (1/1) Methyltransferase domain
PF13581 (1/1) Histidine kinase-like ATPase domain
PF13006 (1/1) Insertion element 4 transposase N-terminal
PF12730 (1/1) ABC-2 family transporter protein
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00296 (1/1) Luciferase-like monooxygenase
PF00202 (1/1) Aminotransferase class-III
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL F-3213 169.11 +- 87.11 2 0 0 0 0.04 +- 0.06 2 20

TIGR01496 (1/2) dihydropteroate synthase
TIGR01205 (1/2) D-alanine--D-alanine ligase
TIGR01082 (1/2) UDP-N-acetylmuramate--L-alanine ligase
PF08310 (1/2) LGFP repeat
PF08245 (1/2) Mur ligase middle domain
PF07995 (1/2) Glucose / Sorbosone dehydrogenase
PF07478 (1/2) D-ala D-ala ligase C-terminus
PF04101 (1/2) Glycosyltransferase family 28 C-terminal domain
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF03033 (1/2) Glycosyltransferase family 28 N-terminal domain
PF02875 (1/2) Mur ligase family, glutamate ligase domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01820 (1/2) D-ala D-ala ligase N-terminus
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01225 (1/2) Mur ligase family, catalytic domain
PF00809 (1/2) Pterin binding enzyme
PF00801 (1/2) PKD domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00218 (1/2) Indole-3-glycerol phosphate synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces sp. TLI_171 1401.11 +- 938.89 2 0 1 1 0.01 +- 0.01 2 21

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14081 (1/2) Domain of unknown function (DUF4262)
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (1/2) SAF domain
PF07811 (1/2) TadE-like protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01476 (1/2) LysM domain
PF01381 (1/2) Helix-turn-helix
PF00881 (1/2) Nitroreductase family
PF00664 (1/2) ABC transporter transmembrane region
PF00482 (1/2) Type II secretion system (T2SS), protein F
PF00437 (1/2) Type II/IV secretion system protein
PF00364 (1/2) Biotin-requiring enzyme
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
Streptomyces malaysiensis 461.57 +- 543.29 3 0 0 0 0.04 +- 0.04 3

No common domains found
Streptomyces sp. NRRL F-5917 35.45 +- 0.00 1 0 0 0 0.08 +- 0.12 1 5

PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
Streptomyces sp. NBRC 110035 728.47 +- 0.00 1 0 0 0 0.02 +- 0.01 1 9

PF17914 (1/1) HopA1 effector protein family
PF13732 (1/1) Domain of unknown function (DUF4162)
PF13649 (1/1) Methyltransferase domain
PF12698 (1/1) ABC-2 family transporter protein
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00664 (1/1) ABC transporter transmembrane region
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter
Streptomyces odonnellii 283.64 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF18135 (1/1) Type ISP C-terminal specificity domain
PF16656 (1/1) Purple acid Phosphatase, N-terminal domain
PF15646 (1/1) Restriction endonuclease fold toxin 2
PF02384 (1/1) N-6 DNA Methylase
PF00664 (1/1) ABC transporter transmembrane region
PF00149 (1/1) Calcineurin-like phosphoesterase
PF00005 (1/1) ABC transporter
Streptomyces sp. DpondAA-E10 328.70 +- 29.99 3 0 2 0 0.05 +- 0.15 3

No common domains found
Streptomyces sp. WMMB 714 101.58 +- 5.92 2 0 0 0 0.07 +- 0.09 2 21

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01891 (1/2) amidohydrolase
PF13738 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF13091 (1/2) PLD-like domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (1/2) NMT1/THI5 like
PF06267 (1/2) Family of unknown function (DUF1028)
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF03466 (1/2) LysR substrate binding domain
PF02386 (1/2) Cation transport protein
PF02254 (1/2) TrkA-N domain
PF02080 (1/2) TrkA-C domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01042 (1/2) Endoribonuclease L-PSP
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00296 (1/2) Luciferase-like monooxygenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (1/2) Sugar (and other) transporter
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. rimosus 73.80 +- 12.86 2 0 1 1 0.06 +- 0.06 2 12

PF14158 (1/2) YndJ-like protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13492 (1/2) GAF domain
PF13471 (1/2) Transglutaminase-like superfamily
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00733 (1/2) Asparagine synthase
PF00149 (1/2) Calcineurin-like phosphoesterase
Streptomyces sp. CNQ766 473.00 +- 215.00 2 0 1 0 0.01 +- 0.00 2 18

TIGR01733 (1/2) amino acid adenylation domain
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13545 (1/2) Crp-like helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00326 (1/2) Prolyl oligopeptidase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00027 (1/2) Cyclic nucleotide-binding domain
Streptomyces sp. ST1015 258.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 5

PF18593 (1/1) CdiI immunity protein
PF18431 (1/1) Bacterial CdiA-CT RNAse A domain
PF13560 (1/1) Helix-turn-helix domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF04149 (1/1) Domain of unknown function (DUF397)
Streptomyces rimosus subsp. rimosus 44.23 +- 0.00 1 0 1 1 0.07 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. FxanaD5 28.26 +- 0.00 1 0 1 1 0.07 +- 0.04 1 7

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF01042 (1/1) Endoribonuclease L-PSP
PF00144 (1/1) Beta-lactamase
Streptomyces jietaisiensis 1032.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF18029 (1/1) Glyoxalase-like domain
PF04055 (1/1) Radical SAM superfamily
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces viridifaciens 642.33 +- 610.97 5 0 1 1 0.03 +- 0.05 5

No common domains found
Streptomyces sp. NRRL F-4428 110.12 +- 0.00 1 0 0 0 0.07 +- 0.06 1 6

PF14903 (1/1) WG containing repeat
PF10042 (1/1) Uncharacterized conserved protein (DUF2278)
PF06983 (1/1) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (1/1) ABC 3 transport family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00005 (1/1) ABC transporter
Streptomyces sp. TLI_053 329.29 +- 169.24 6 0 3 2 0.03 +- 0.03 6

No common domains found
Streptomyces bikiniensis 555.69 +- 39.69 2 0 1 0 0.01 +- 0.00 2 25

TIGR02124 (1/2) hydrogenase expression/formation protein HypE
TIGR01891 (1/2) amidohydrolase
TIGR00709 (1/2) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/2) carbamoyltransferase HypF
PF17788 (1/2) HypF Kae1-like domain
PF13535 (1/2) ATP-grasp domain
PF12680 (1/2) SnoaL-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF07503 (1/2) HypF finger
PF05977 (1/2) Transmembrane secretion effector
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01300 (1/2) Telomere recombination
PF01266 (1/2) FAD dependent oxidoreductase
PF00857 (1/2) Isochorismatase family
PF00708 (1/2) Acylphosphatase
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (1/2) NUDIX domain
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
Streptomyces aureus 144.07 +- 107.30 4 0 1 0 0.06 +- 0.10 4

No common domains found
Streptomyces sp. 73 59.50 +- 18.47 3 0 1 0 0.07 +- 0.06 3

No common domains found
Streptomyces sp. LaPpAH-95 466.47 +- 53.53 2 0 1 1 0.02 +- 0.02 2 19

TIGR03396 (1/2) phospholipase C, phosphocholine-specific
TIGR01258 (1/2) phosphoglycerate mutase 1 family
TIGR01060 (1/2) phosphopyruvate hydratase
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05506 (1/2) Domain of unknown function (DUF756)
PF04185 (1/2) Phosphoesterase family
PF04055 (1/2) Radical SAM superfamily
PF03965 (1/2) Penicillinase repressor
PF03952 (1/2) Enolase, N-terminal domain
PF03453 (1/2) MoeA N-terminal region (domain I and II)
PF02441 (1/2) Flavoprotein
PF01712 (1/2) Deoxynucleoside kinase
PF01435 (1/2) Peptidase family M48
PF00994 (1/2) Probable molybdopterin binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00293 (1/2) NUDIX domain
PF00113 (1/2) Enolase, C-terminal TIM barrel domain
Streptomyces sp. NEAU-D10 72.56 +- 0.00 1 0 0 0 0.04 +- 0.00 1 5

TIGR03668 (1/1) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (1/1) probable F420-dependent oxidoreductase, Rv2161c family
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF01243 (1/1) Pyridoxamine 5'-phosphate oxidase
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces sp. WM6386 210.60 +- 189.80 2 0 1 0 0.05 +- 0.05 2 11

PF12802 (1/2) MarR family
PF12680 (1/2) SnoaL-like domain
PF09084 (1/2) NMT1/THI5 like
PF01937 (1/2) Protein of unknown function DUF89
PF01483 (1/2) Proprotein convertase P-domain
PF01323 (1/2) DSBA-like thioredoxin domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
Streptomyces europaeiscabiei 384.42 +- 157.38 2 0 0 0 0.02 +- 0.01 2 16

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF12146 (1/2) Serine aminopeptidase, S33
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07366 (1/2) SnoaL-like polyketide cyclase
PF07179 (1/2) SseB protein N-terminal domain
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04978 (1/2) Protein of unknown function (DUF664)
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces sp. B9173 101.74 +- 0.00 1 0 0 0 0.03 +- 0.05 1 4

PF13480 (1/1) Acetyltransferase (GNAT) domain
PF02156 (1/1) Glycosyl hydrolase family 26
PF01522 (1/1) Polysaccharide deacetylase
PF00535 (1/1) Glycosyl transferase family 2
Streptomyces vitaminophilus 23.45 +- 0.00 1 0 0 0 0.09 +- 0.07 1 3

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (1/1) Methyltransferase domain
PF00753 (1/1) Metallo-beta-lactamase superfamily
Streptomyces sp. NRRL F-3273 135.20 +- 0.00 1 0 0 0 0.04 +- 0.03 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces lavendulae subsp. lavendulae 1002.14 +- 120.69 3 0 3 0 0.02 +- 0.04 3 4

PF13649 (2/3) Methyltransferase domain
PF05193 (2/3) Peptidase M16 inactive domain
PF00675 (2/3) Insulinase (Peptidase family M16)
PF00005 (2/3) ABC transporter
Streptomyces sp. MUSC 1 202.22 +- 57.78 2 0 1 0 0.02 +- 0.03 2 15

TIGR01733 (1/2) amino acid adenylation domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF14681 (1/2) Uracil phosphoribosyltransferase
PF14027 (1/2) Questin oxidase-like
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF11303 (1/2) Protein of unknown function (DUF3105)
PF09286 (1/2) Pro-kumamolisin, activation domain
PF07690 (1/2) Major Facilitator Superfamily
PF04227 (1/2) Indigoidine synthase A like protein
PF03713 (1/2) Domain of unknown function (DUF305)
PF01361 (1/2) Tautomerase enzyme
PF00975 (1/2) Thioesterase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00082 (1/2) Subtilase family
Streptomyces lincolnensis 803.96 +- 685.80 4 0 1 1 0.04 +- 0.09 4 4

PF17914 (2/4) HopA1 effector protein family
PF01636 (2/4) Phosphotransferase enzyme family
PF00664 (2/4) ABC transporter transmembrane region
PF00005 (2/4) ABC transporter
Streptomyces sp. CNQ-525 812.50 +- 472.09 4 0 2 0 0.01 +- 0.01 4 1

PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
Streptomyces sp. 150FB 490.74 +- 594.82 7 0 3 0 0.05 +- 0.08 7

No common domains found
Streptomyces rapamycinicus NRRL 5491 378.81 +- 238.69 3 0 1 0 0.03 +- 0.09 3 3

PF09339 (2/3) IclR helix-turn-helix domain
PF07690 (2/3) Major Facilitator Superfamily
PF01614 (2/3) Bacterial transcriptional regulator
Streptomyces sp. NRRL F-5053 606.67 +- 0.00 1 0 1 0 0.01 +- 0.00 1 8

PF17914 (1/1) HopA1 effector protein family
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00535 (1/1) Glycosyl transferase family 2
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces xiamenensis 309.30 +- 382.11 4 0 0 0 0.07 +- 0.10 4

No common domains found
Streptomyces xinghaiensis 153.06 +- 9.30 3 0 2 1 0.06 +- 0.09 3 1

PF13419 (2/3) Haloacid dehalogenase-like hydrolase
Streptomyces sp. NRRL S-340 520.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 5

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00067 (1/1) Cytochrome P450
Streptomyces agglomeratus 1508.05 +- 1314.81 2 0 1 1 0.02 +- 0.04 2 41

PF00005 (2/2) ABC transporter
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (1/2) ATP-grasp domain
PF13458 (1/2) Periplasmic binding protein
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01497 (1/2) Periplasmic binding protein
PF01425 (1/2) Amidase
PF01070 (1/2) FMN-dependent dehydrogenase
PF01032 (1/2) FecCD transport family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00682 (1/2) HMGL-like
PF00664 (1/2) ABC transporter transmembrane region
PF00557 (1/2) Metallopeptidase family M24
PF00384 (1/2) Molybdopterin oxidoreductase
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II
Streptomyces longwoodensis 645.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 7

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (1/1) Iron-sulfur cluster-binding domain
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF01980 (1/1) tRNA-methyltransferase O
PF01494 (1/1) FAD binding domain
Streptomyces sp. PsTaAH-124 130.00 +- 0.00 1 0 0 0 0.02 +- 0.00 1 5

TIGR02532 (1/1) prepilin-type N-terminal cleavage/methylation domain
PF07963 (1/1) Prokaryotic N-terminal methylation motif
PF06750 (1/1) Bacterial Peptidase A24 N-terminal domain
PF03551 (1/1) Transcriptional regulator PadR-like family
PF01478 (1/1) Type IV leader peptidase family
Streptomyces europaeiscabiei 196.81 +- 147.19 2 0 0 0 0.04 +- 0.03 2 14

PF13478 (1/2) XdhC Rossmann domain
PF09339 (1/2) IclR helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (1/2) XdhC and CoxI family
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00561 (1/2) alpha/beta hydrolase fold
PF00296 (1/2) Luciferase-like monooxygenase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (1/2) short chain dehydrogenase
Streptomyces acidiscabies 355.86 +- 0.00 1 0 0 0 0.08 +- 0.23 1 19

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF10901 (1/1) Protein of unknown function (DUF2690)
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01471 (1/1) Putative peptidoglycan binding domain
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00664 (1/1) ABC transporter transmembrane region
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00005 (1/1) ABC transporter
Streptomyces sp. Tu 4128 266.32 +- 0.00 1 0 0 0 0.03 +- 0.01 1 8

TIGR00976 (1/1) hydrolase CocE/NonD family protein
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/1) alpha/beta hydrolase fold
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/1) Phosphotriesterase family
PF01494 (1/1) FAD binding domain
PF00753 (1/1) Metallo-beta-lactamase superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family
Streptomyces glauciniger 910.00 +- 650.00 2 0 0 0 0.01 +- 0.00 2 12

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF17912 (1/2) MalK OB fold domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08402 (1/2) TOBE domain
PF02615 (1/2) Malate/L-lactate dehydrogenase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces sp. Z022 458.05 +- 32.60 2 0 1 0 0.03 +- 0.02 2 29

PF07690 (2/2) Major Facilitator Superfamily
TIGR04444 (1/2) chorismatase, FkbO/Hyg5 family
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF17645 (1/2) Arylmalonate decarboxylase
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF08443 (1/2) RimK-like ATP-grasp domain
PF06339 (1/2) Ectoine synthase
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01841 (1/2) Transglutaminase-like superfamily
PF01546 (1/2) Peptidase family M20/M25/M40
PF01474 (1/2) Class-II DAHP synthetase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
Streptomyces griseorubiginosus 737.70 +- 765.25 4 0 0 1 0.02 +- 0.06 4

No common domains found
Streptomyces sp. AmelKG-A3 741.09 +- 650.13 4 0 1 1 0.02 +- 0.02 4 3

PF07690 (3/4) Major Facilitator Superfamily
PF13649 (2/4) Methyltransferase domain
PF00005 (2/4) ABC transporter
Streptomyces sp. Root1310 50.00 +- 0.00 1 0 0 0 0.04 +- 0.03 1 4

PF12802 (1/1) MarR family
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces sp. cf124 648.69 +- 644.60 3 0 2 2 0.03 +- 0.04 3 2

PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter
Streptomyces cavernae 406.92 +- 213.38 5 0 1 0 0.02 +- 0.03 5

No common domains found
Streptomyces guanduensis 43.33 +- 0.00 1 0 0 0 0.05 +- 0.04 1 2

PF00171 (1/1) Aldehyde dehydrogenase family
PF00106 (1/1) short chain dehydrogenase
Streptomyces sp. Ag82_G5-5 368.63 +- 170.25 5 0 0 1 0.02 +- 0.03 5

No common domains found
Streptomyces sp. KhCrAH-43 520.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 5

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02441 (1/1) Flavoprotein
PF02310 (1/1) B12 binding domain
Streptomyces sp. F-1 79.05 +- 41.68 3 0 1 1 0.04 +- 0.04 3

No common domains found
Streptomyces sp. LAM7114 1243.71 +- 873.82 5 0 0 0 0.03 +- 0.15 5

No common domains found
Streptomyces cyaneogriseus subsp. noncyanogenus 790.65 +- 672.18 3 0 1 0 0.02 +- 0.03 3 3

PF17914 (2/3) HopA1 effector protein family
PF02441 (2/3) Flavoprotein
PF00296 (2/3) Luciferase-like monooxygenase
Streptomyces sp. DpondAA-F4a 834.17 +- 0.00 1 0 1 0 0.01 +- 0.00 1 10

TIGR01891 (1/1) amidohydrolase
TIGR01821 (1/1) 5-aminolevulinic acid synthase
PF16884 (1/1) N-terminal domain of oxidoreductase
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/1) Peptidase family M20/M25/M40
PF00155 (1/1) Aminotransferase class I and II
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces xylophagus 333.11 +- 358.32 5 0 1 1 0.02 +- 0.02 5

No common domains found
Streptomyces sp. NRRL WC-3723 387.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 4

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
Streptomyces hygroscopicus subsp. jinggangensis 5008 457.94 +- 727.00 6 0 2 0 0.06 +- 0.07 6

No common domains found
Streptomyces rimosus subsp. rimosus 223.88 +- 134.85 5 0 2 1 0.03 +- 0.02 5

No common domains found
Embleya scabrispora 205.40 +- 184.60 2 0 2 1 0.02 +- 0.03 2 11

TIGR03328 (1/2) methylthioribulose-1-phosphate dehydratase
TIGR00512 (1/2) S-methyl-5-thioribose-1-phosphate isomerase
PF11259 (1/2) Protein of unknown function (DUF3060)
PF04055 (1/2) Radical SAM superfamily
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (1/2) B12 binding domain
PF01522 (1/2) Polysaccharide deacetylase
PF01008 (1/2) Initiation factor 2 subunit family
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
Streptomyces hygroscopicus 402.39 +- 446.48 7 0 2 0 0.04 +- 0.08 7

No common domains found
Streptomyces globosus 731.00 +- 497.76 3 0 1 1 0.01 +- 0.00 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. NRRL B-24720 283.93 +- 79.13 3 0 0 0 0.06 +- 0.15 3

No common domains found
Streptomyces sp. NRRL F-2890 480.79 +- 491.75 3 0 1 0 0.02 +- 0.02 3

No common domains found
Streptomyces sp. CNR698 1003.43 +- 959.62 2 0 2 1 0.03 +- 0.06 2 14

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/2) Helix-turn-helix domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF04149 (1/2) Domain of unknown function (DUF397)
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00905 (1/2) Penicillin binding protein transpeptidase domain
PF00881 (1/2) Nitroreductase family
PF00266 (1/2) Aminotransferase class-V
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
Streptomyces leeuwenhoekii 1419.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 6

PF17914 (1/1) HopA1 effector protein family
PF01061 (1/1) ABC-2 type transporter
PF00891 (1/1) O-methyltransferase domain
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces pyridomyceticus 498.08 +- 469.42 2 0 0 1 0.03 +- 0.04 2 9

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08007 (1/2) Cupin superfamily protein
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (1/2) Radical SAM superfamily
PF01061 (1/2) ABC-2 type transporter
PF00717 (1/2) Peptidase S24-like
PF00248 (1/2) Aldo/keto reductase family
PF00005 (1/2) ABC transporter
Streptomyces sp. SM17 33.91 +- 0.00 1 0 0 0 0.06 +- 0.02 1 4

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
Streptomyces erythrochromogenes 81.67 +- 0.00 1 0 0 0 0.09 +- 0.17 1 7

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/1) Sigma-70, region 4
PF04542 (1/1) Sigma-70 region 2
PF03995 (1/1) Peptidase inhibitor family I36
PF01551 (1/1) Peptidase family M23
PF01427 (1/1) D-ala-D-ala dipeptidase
PF00877 (1/1) NlpC/P60 family
Streptomyces scopuliridis RB72 544.76 +- 400.21 3 0 1 0 0.02 +- 0.01 3

No common domains found
Streptomyces albus 258.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 1

PF04655 (1/1) Aminoglycoside/hydroxyurea antibiotic resistance kinase
Streptomyces sp. TSRI0281 161.98 +- 65.19 5 0 3 2 0.04 +- 0.08 5

No common domains found
Streptomyces sp. ADI92-24 258.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 3

PF10137 (1/1) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (1/1) Streptomyces sporulation and cell division protein, SsgA
PF00294 (1/1) pfkB family carbohydrate kinase
Streptomyces albidoflavus 81.25 +- 0.00 1 0 0 0 0.02 +- 0.02 1 4

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces rimosus subsp. rimosus 74.81 +- 42.70 3 0 1 1 0.06 +- 0.09 3

No common domains found
Streptomyces griseoviridis 320.47 +- 296.02 4 0 0 0 0.02 +- 0.02 4

No common domains found
Streptomyces sp. SM10 229.59 +- 141.11 3 0 1 0 0.06 +- 0.09 3

No common domains found
Streptomyces flavochromogenes 496.89 +- 322.88 5 0 3 3 0.02 +- 0.05 5

No common domains found
Streptomyces canus 30.79 +- 0.00 1 0 0 0 0.10 +- 0.02 1 4

TIGR03328 (1/1) methylthioribulose-1-phosphate dehydratase
TIGR01691 (1/1) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (1/1) ARD/ARD' family
PF00596 (1/1) Class II Aldolase and Adducin N-terminal domain
Streptomyces griseoruber 853.95 +- 746.46 4 0 1 0 0.03 +- 0.05 4 1

PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
Streptomyces sp. HB202 339.68 +- 115.22 3 0 1 1 0.04 +- 0.06 3 2

PF00005 (3/3) ABC transporter
PF00664 (2/3) ABC transporter transmembrane region
Streptomyces cavourensis 244.36 +- 204.16 4 0 2 0 0.06 +- 0.15 4 1

PF00005 (2/4) ABC transporter
Streptomyces mirabilis 206.64 +- 64.26 2 0 0 0 0.06 +- 0.09 2 17

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF14025 (1/2) Protein of unknown function (DUF4241)
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01610 (1/2) Transposase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. 1222.2 153.70 +- 0.00 1 0 0 0 0.05 +- 0.03 1 7

PF17900 (1/1) Peptidase M1 N-terminal domain
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (1/1) DJ-1/PfpI family
PF01433 (1/1) Peptidase family M1 domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00082 (1/1) Subtilase family
Streptomyces sp. CB02009 598.01 +- 600.17 5 0 2 2 0.02 +- 0.05 5

No common domains found
Streptomyces sp. MUSC 93 891.83 +- 940.89 3 0 0 0 0.02 +- 0.04 3 2

PF02784 (2/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family
Streptomyces sp. NRRL F-525 407.92 +- 325.83 6 0 0 1 0.02 +- 0.02 6

No common domains found
Streptomyces hygroscopicus subsp. jinggangensis TL01 530.23 +- 690.65 6 0 2 0 0.05 +- 0.06 6

No common domains found
Streptomyces sp. EN27 1439.64 +- 1398.36 2 0 1 1 0.02 +- 0.04 2 16

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17866 (1/2) AAA lid domain
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13229 (1/2) Right handed beta helix region
PF12730 (1/2) ABC-2 family transporter protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF00664 (1/2) ABC transporter transmembrane region
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
Streptomyces sp. SM11 435.18 +- 0.00 1 0 1 0 0.09 +- 0.10 1 29

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF13535 (1/1) ATP-grasp domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00501 (1/1) AMP-binding enzyme
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces sp. LaPpAH-199 281.67 +- 0.00 1 0 0 0 0.02 +- 0.01 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces sp. CB02488 788.86 +- 767.24 4 0 1 0 0.02 +- 0.10 4 1

PF00082 (2/4) Subtilase family
Streptomyces californicus 135.20 +- 0.00 1 0 0 0 0.04 +- 0.03 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces sp. SPB074 780.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 12

TIGR02144 (1/1) lysine biosynthesis enzyme LysX
TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00761 (1/1) acetylglutamate kinase
PF08443 (1/1) RimK-like ATP-grasp domain
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
Streptomyces acidiscabies 319.58 +- 27.08 2 0 1 0 0.07 +- 0.21 2 26

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01746 (1/2) thioester reductase domain
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10901 (1/2) Protein of unknown function (DUF2690)
PF08443 (1/2) RimK-like ATP-grasp domain
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. rimosus 124.03 +- 35.65 3 0 1 1 0.03 +- 0.02 3

No common domains found
Streptomyces exfoliatus 276.86 +- 193.89 4 0 2 2 0.04 +- 0.06 4 1

PF07690 (2/4) Major Facilitator Superfamily
Streptomyces avermitilis 161.59 +- 78.28 3 0 1 0 0.05 +- 0.05 3 2

PF07690 (2/3) Major Facilitator Superfamily
PF00348 (2/3) Polyprenyl synthetase
Streptomyces sp. 2333.5 410.69 +- 354.19 6 0 3 1 0.02 +- 0.03 6 1

PF07690 (4/6) Major Facilitator Superfamily
Streptomyces scabiei 87.22 131.33 +- 0.00 1 0 0 0 0.08 +- 0.17 1 10

PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF05025 (1/1) RbsD / FucU transport protein family
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF00430 (1/1) ATP synthase B/B' CF(0)
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00005 (1/1) ABC transporter
Streptomyces abyssalis 346.67 +- 0.00 1 0 0 0 0.01 +- 0.01 1 6

PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain
Streptomyces canus 299MFChir4.1 388.38 +- 219.49 5 0 0 1 0.01 +- 0.02 5

No common domains found
Streptomyces atriruber 146.59 +- 0.00 1 0 0 0 0.07 +- 0.12 1 4

PF09084 (1/1) NMT1/THI5 like
PF04909 (1/1) Amidohydrolase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter
Streptomyces sp. IB2014 011-1 342.21 +- 307.79 2 0 1 1 0.06 +- 0.08 2 7

PF14518 (1/2) Iron-containing redox enzyme
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF04055 (1/2) Radical SAM superfamily
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family
Streptomyces qinglanensis 2797.24 +- 0.00 1 0 1 1 0.02 +- 0.01 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter
Streptomyces griseus 371.43 +- 0.00 1 0 1 0 0.01 +- 0.00 1 8

PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00550 (1/1) Phosphopantetheine attachment site
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Streptomyces sp. LamerLS-316 70.91 +- 0.00 1 0 0 1 0.04 +- 0.03 1 4

PF13360 (1/1) PQQ-like domain
PF04672 (1/1) S-adenosyl methyltransferase
PF04073 (1/1) Aminoacyl-tRNA editing domain
PF00069 (1/1) Protein kinase domain
Streptomyces violaceusniger Tu 4113 211.89 +- 91.85 3 0 1 0 0.05 +- 0.07 3

No common domains found
Streptomyces sp. ST1020 31.38 +- 0.00 1 0 0 0 0.06 +- 0.07 1 5

PF18593 (1/1) CdiI immunity protein
PF18431 (1/1) Bacterial CdiA-CT RNAse A domain
PF13560 (1/1) Helix-turn-helix domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF04149 (1/1) Domain of unknown function (DUF397)
Streptomyces sp. AS58 363.74 +- 289.46 6 0 2 1 0.03 +- 0.07 6

No common domains found
Streptomyces sp. AA1529 4680.00 +- 0.00 1 0 1 1 0.01 +- 0.01 1 9

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13601 (1/1) Winged helix DNA-binding domain
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter
Streptomyces sp. PpalLS-921 185.10 +- 72.34 3 0 1 2 0.03 +- 0.03 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces alboflavus 556.62 +- 256.00 3 0 3 0 0.01 +- 0.00 3 3

PF00975 (2/3) Thioesterase domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
Streptomyces sp. NRRL F-3218 173.48 +- 0.00 1 0 0 0 0.03 +- 0.04 1 10

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
Streptomyces iakyrus 1393.75 +- 1057.48 3 0 1 1 0.03 +- 0.04 3 3

PF13649 (2/3) Methyltransferase domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00005 (2/3) ABC transporter
Streptomyces sp. PAN_FS17 150.39 +- 28.04 2 0 0 1 0.04 +- 0.05 2 17

TIGR04267 (1/2) HEXXH motif domain
TIGR01187 (1/2) polyamine ABC transporter, ATP-binding protein
TIGR00702 (1/2) YcaO-type kinase domain
PF18029 (1/2) Glyoxalase-like domain
PF13489 (1/2) Methyltransferase domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08402 (1/2) TOBE domain
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter
Streptomyces pseudovenezuelae 365.93 +- 267.45 4 0 0 0 0.02 +- 0.03 4 4

PF09339 (2/4) IclR helix-turn-helix domain
PF01614 (2/4) Bacterial transcriptional regulator
PF00175 (2/4) Oxidoreductase NAD-binding domain
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces sp. EN23 544.76 +- 0.00 1 0 1 1 0.04 +- 0.03 1 11

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00005 (1/1) ABC transporter
Streptomyces albus 107.50 +- 64.50 2 0 0 0 0.05 +- 0.09 2 6

PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
Streptomyces sp. Mg1 598.25 +- 929.25 7 0 2 3 0.04 +- 0.10 7

No common domains found
Streptomyces sp. KS_16 205.21 +- 84.25 4 0 1 1 0.06 +- 0.18 4 1

PF00005 (2/4) ABC transporter
Streptomyces scabiei 150.50 +- 107.50 2 0 0 0 0.05 +- 0.03 2 12

TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02036 (1/2) SCP-2 sterol transfer family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter
Streptomyces griseus subsp. griseus 650.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF00246 (1/1) Zinc carboxypeptidase
PF00082 (1/1) Subtilase family
Streptomyces griseoflavus Tu4000 192.98 +- 31.73 2 0 0 0 0.03 +- 0.02 2 12

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13407 (1/2) Periplasmic binding protein domain
PF07730 (1/2) Histidine kinase
PF07702 (1/2) UTRA domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03621 (1/2) MbtH-like protein
PF01694 (1/2) Rhomboid family
PF00501 (1/2) AMP-binding enzyme
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces albidoflavus 540.57 +- 0.00 1 0 1 0 0.07 +- 0.06 1 28

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter
Streptomyces lincolnensis 463.59 +- 138.41 2 0 0 1 0.03 +- 0.07 2 21

PF17914 (2/2) HopA1 effector protein family
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01426 (1/2) glycosyltransferase, MGT family
PF13692 (1/2) Glycosyl transferases group 1
PF13601 (1/2) Winged helix DNA-binding domain
PF13469 (1/2) Sulfotransferase family
PF12698 (1/2) ABC-2 family transporter protein
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02441 (1/2) Flavoprotein
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
Streptomyces sampsonii 55.29 +- 0.00 1 0 0 0 0.07 +- 0.09 1 4

PF04203 (1/1) Sortase domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/1) Acetyltransferase (GNAT) family
Streptomyces rimosus 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. 96-12 247.00 +- 13.00 2 0 0 0 0.02 +- 0.01 2 13

TIGR01910 (1/2) peptidase, ArgE/DapE family
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13602 (1/2) Zinc-binding dehydrogenase
PF13564 (1/2) DoxX-like family
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01546 (1/2) Peptidase family M20/M25/M40
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00296 (1/2) Luciferase-like monooxygenase
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
Streptomyces cyaneofuscatus 477.78 +- 0.00 1 0 0 0 0.02 +- 0.02 1 10

PF12833 (1/1) Helix-turn-helix domain
PF02518 (1/1) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02311 (1/1) AraC-like ligand binding domain
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00664 (1/1) ABC transporter transmembrane region
PF00561 (1/1) alpha/beta hydrolase fold
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL S-1521 343.04 +- 193.43 3 0 2 2 0.03 +- 0.04 3 4

PF07690 (3/3) Major Facilitator Superfamily
PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
PF00326 (2/3) Prolyl oligopeptidase family
Streptomyces sp. NRRL S-98 531.82 +- 0.00 1 0 0 0 0.03 +- 0.01 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces albulus 505.07 +- 694.41 8 0 3 1 0.03 +- 0.07 8

No common domains found
Streptomyces rimosus R6-500 57.78 +- 0.00 1 0 1 1 0.05 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sp. Tu6071 516.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

PF13466 (1/1) STAS domain
PF08031 (1/1) Berberine and berberine like
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF03992 (1/1) Antibiotic biosynthesis monooxygenase
PF02607 (1/1) B12 binding domain
PF02310 (1/1) B12 binding domain
PF01565 (1/1) FAD binding domain
Streptomyces sp. WAC04770 4797.00 +- 1833.00 2 0 1 0 0.01 +- 0.00 2 24

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF17914 (1/2) HopA1 effector protein family
PF13847 (1/2) Methyltransferase domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13115 (1/2) YtkA-like
PF11468 (1/2) Aromatic prenyltransferase Orf2
PF05193 (1/2) Peptidase M16 inactive domain
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02441 (1/2) Flavoprotein
PF01676 (1/2) Metalloenzyme superfamily
PF01527 (1/2) Transposase
PF01061 (1/2) ABC-2 type transporter
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00403 (1/2) Heavy-metal-associated domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I
Streptomyces sp. 11-1-2 144.50 +- 60.79 4 0 0 0 0.04 +- 0.04 4 4

PF16353 (2/4) Domain of unknown function(DUF4981)
PF02929 (2/4) Beta galactosidase small chain
PF02837 (2/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/4) Glycosyl hydrolases family 2, TIM barrel domain
Streptomyces sp. DvalAA-21 328.70 +- 29.99 3 0 2 0 0.05 +- 0.15 3

No common domains found
Streptomyces sp. GKU 895 32.94 +- 0.00 1 0 0 0 0.06 +- 0.07 1 6

PF14525 (1/1) AraC-binding-like domain
PF12833 (1/1) Helix-turn-helix domain
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces tsukubensis 236.25 +- 115.39 3 0 2 1 0.02 +- 0.03 3

No common domains found
Streptomyces sp. Root369 304.58 +- 195.15 3 0 0 0 0.02 +- 0.01 3

No common domains found
Streptomyces sp. NRRL F-4489 240.41 +- 17.59 2 0 0 0 0.07 +- 0.15 2 20

TIGR02276 (1/2) 40-residue YVTN family beta-propeller repeat
TIGR01879 (1/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (1/2) dihydroorotate dehydrogenase family protein
TIGR00857 (1/2) dihydroorotase, multifunctional complex type
PF13305 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13160 (1/2) Protein of unknown function (DUF3995)
PF10418 (1/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF10415 (1/2) Fumarase C C-terminus
PF10282 (1/2) Lactonase, 7-bladed beta-propeller
PF09339 (1/2) IclR helix-turn-helix domain
PF07931 (1/2) Chloramphenicol phosphotransferase-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02656 (1/2) Domain of unknown function (DUF202)
PF01979 (1/2) Amidohydrolase family
PF01833 (1/2) IPT/TIG domain
PF01614 (1/2) Bacterial transcriptional regulator
PF01546 (1/2) Peptidase family M20/M25/M40
PF01180 (1/2) Dihydroorotate dehydrogenase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00206 (1/2) Lyase
Streptomyces sp. WAC 04229 576.98 +- 0.00 1 0 0 0 0.01 +- 0.01 1 12

TIGR01554 (1/1) phage major capsid protein, HK97 family
TIGR01543 (1/1) phage prohead protease, HK97 family
TIGR01537 (1/1) phage portal protein, HK97 family
PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF09250 (1/1) Bifunctional DNA primase/polymerase, N-terminal
PF05065 (1/1) Phage capsid family
PF04860 (1/1) Phage portal protein
PF04851 (1/1) Type III restriction enzyme, res subunit
PF04586 (1/1) Caudovirus prohead serine protease
PF01844 (1/1) HNH endonuclease
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00271 (1/1) Helicase conserved C-terminal domain
Streptomyces rimosus 44.23 +- 0.00 1 0 1 1 0.07 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces exfoliatus 318.56 +- 247.95 4 0 2 2 0.03 +- 0.03 4 1

PF07690 (2/4) Major Facilitator Superfamily
Streptomyces sp. XY152 45.22 +- 0.00 1 0 0 0 0.04 +- 0.06 1 3

PF01427 (1/1) D-ala-D-ala dipeptidase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00293 (1/1) NUDIX domain
Streptomyces sp. ok210 84.75 +- 27.42 2 0 0 0 0.04 +- 0.02 2 11

PF17291 (1/2) N-terminal domain of M60-like peptidases
PF13402 (1/2) Peptidase M60, enhancin and enhancin-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF10022 (1/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (1/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03795 (1/2) YCII-related domain
PF02884 (1/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (1/2) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
Streptomyces badius 798.43 +- 45.93 2 0 1 1 0.02 +- 0.01 2 12

PF00005 (2/2) ABC transporter
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00296 (1/2) Luciferase-like monooxygenase
PF00069 (1/2) Protein kinase domain
Streptomyces sp. F-7 35.59 +- 0.00 1 0 0 0 0.06 +- 0.05 1 4

PF13516 (1/1) Leucine Rich repeat
PF13203 (1/1) Putative metallopeptidase domain
PF09967 (1/1) VWA-like domain (DUF2201)
PF07728 (1/1) AAA domain (dynein-related subfamily)
Streptomyces spongiicola 2006.67 +- 0.00 1 0 1 1 0.01 +- 0.01 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family
Streptomyces variegatus 434.07 +- 544.57 3 0 2 0 0.04 +- 0.06 3

No common domains found
Streptomyces sp. CEV 2-1 195.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 3

PF10137 (1/1) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (1/1) Streptomyces sporulation and cell division protein, SsgA
PF00294 (1/1) pfkB family carbohydrate kinase
Streptomyces sp. NBRC 110028 492.85 +- 334.12 5 0 1 0 0.02 +- 0.02 5

No common domains found
Streptomyces sp. Tu 6176 182.87 +- 133.35 2 0 1 1 0.04 +- 0.04 2 10

TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13471 (1/2) Transglutaminase-like superfamily
PF05544 (1/2) Proline racemase
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (1/2) Asparagine synthase
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. rimosus 74.81 +- 42.70 3 0 1 1 0.06 +- 0.09 3

No common domains found
Streptomyces globisporus 410.66 +- 348.26 2 0 0 0 0.03 +- 0.04 2 12

PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF05193 (1/2) Peptidase M16 inactive domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00455 (1/2) DeoR C terminal sensor domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. NRRL S-241 248.19 +- 24.12 3 0 2 0 0.05 +- 0.14 3

No common domains found
Streptomyces olivochromogenes 46.44 +- 0.00 1 0 0 0 0.06 +- 0.04 1 4

PF13796 (1/1) Putative sensor
PF07730 (1/1) Histidine kinase
PF01874 (1/1) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (1/1) Dioxygenase
Streptomyces sp. UNC401CLCol 26.00 +- 0.00 1 0 1 1 0.08 +- 0.03 1 7

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF01042 (1/1) Endoribonuclease L-PSP
PF00144 (1/1) Beta-lactamase
Streptomyces albus subsp. albus 247.53 +- 212.56 3 0 2 2 0.06 +- 0.07 3 3

PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter
Streptomyces aidingensis 390.00 +- 0.00 1 0 1 1 0.01 +- 0.01 1 8

PF13191 (1/1) AAA ATPase domain
PF13185 (1/1) GAF domain
PF07690 (1/1) Major Facilitator Superfamily
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04055 (1/1) Radical SAM superfamily
PF00211 (1/1) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/1) Subtilase family
PF00069 (1/1) Protein kinase domain
Streptomyces roseoverticillatus 75.53 +- 35.14 2 0 1 0 0.08 +- 0.13 2 16

PF07690 (2/2) Major Facilitator Superfamily
TIGR00556 (1/2) phosphopantetheine--protein transferase domain
TIGR00027 (1/2) methyltransferase, TIGR00027 family
PF12840 (1/2) Helix-turn-helix domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF11583 (1/2) P-aminobenzoate N-oxygenase AurF
PF08386 (1/2) TAP-like protein
PF06628 (1/2) Catalase-related immune-responsive
PF06259 (1/2) Alpha/beta hydrolase
PF05977 (1/2) Transmembrane secretion effector
PF04072 (1/2) Leucine carboxyl methyltransferase
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (1/2) MaoC like domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00199 (1/2) Catalase
Streptomyces sp. SAI-083 311.06 +- 417.97 4 0 1 0 0.03 +- 0.05 4 1

PF00440 (2/4) Bacterial regulatory proteins, tetR family
Streptomyces sp. SM12 1239.18 +- 1314.44 3 0 2 1 0.01 +- 0.01 3

No common domains found
Streptomyces albulus 659.92 +- 738.82 6 0 2 1 0.02 +- 0.07 6

No common domains found
Streptomyces nanshensis 390.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 4

PF07690 (1/1) Major Facilitator Superfamily
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF01522 (1/1) Polysaccharide deacetylase
PF01042 (1/1) Endoribonuclease L-PSP
Streptomyces sp. NRRL F-6491 619.35 +- 411.04 3 0 0 0 0.02 +- 0.06 3 1

PF05977 (2/3) Transmembrane secretion effector
Streptomyces sp. 3212.5 956.95 +- 577.81 3 0 1 1 0.04 +- 0.12 3 1

PF00005 (2/3) ABC transporter
Streptomyces sp. RTd22 126.26 +- 28.16 4 0 0 1 0.06 +- 0.10 4

No common domains found
Streptomyces sp. NRRL S-481 1032.00 +- 516.00 2 0 1 1 0.01 +- 0.00 2 11

PF13480 (1/2) Acetyltransferase (GNAT) domain
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF02310 (1/2) B12 binding domain
PF00400 (1/2) WD domain, G-beta repeat
PF00248 (1/2) Aldo/keto reductase family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
Streptomyces sp. 3213.3 271.29 +- 187.76 3 0 1 0 0.03 +- 0.04 3

No common domains found
Streptomyces sp. endophyte_N2 117.74 +- 0.00 1 0 0 0 0.07 +- 0.12 1 9

PF13622 (1/1) Thioesterase-like superfamily
PF12146 (1/1) Serine aminopeptidase, S33
PF00872 (1/1) Transposase, Mutator family
PF00561 (1/1) alpha/beta hydrolase fold
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00487 (1/1) Fatty acid desaturase
PF00301 (1/1) Rubredoxin
PF00067 (1/1) Cytochrome P450
Streptomyces flaveolus 149.44 +- 26.28 2 0 0 0 0.07 +- 0.09 2 21

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (1/2) Alpha galactosidase A
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/2) Enolase C-terminal domain-like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/2) FCD domain
PF06628 (1/2) Catalase-related immune-responsive
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01475 (1/2) Ferric uptake regulator family
PF01081 (1/2) KDPG and KHG aldolase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00248 (1/2) Aldo/keto reductase family
PF00199 (1/2) Catalase
Streptomyces sp. ADI95-16 719.80 +- 909.03 7 0 3 3 0.04 +- 0.14 7 1

PF00005 (4/7) ABC transporter
Streptomyces sp. Z26 1054.77 +- 0.00 1 0 1 1 0.02 +- 0.03 1 13

TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein
PF13581 (1/1) Histidine kinase-like ATPase domain
PF13471 (1/1) Transglutaminase-like superfamily
PF12679 (1/1) ABC-2 family transporter protein
PF07994 (1/1) Myo-inositol-1-phosphate synthase
PF07730 (1/1) Histidine kinase
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01494 (1/1) FAD binding domain
PF01061 (1/1) ABC-2 type transporter
PF00733 (1/1) Asparagine synthase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter
Streptomyces griseoaurantiacus M045 1032.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 8

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF18029 (1/1) Glyoxalase-like domain
PF04055 (1/1) Radical SAM superfamily
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces coelicoflavus ZG0656 209.40 +- 0.00 1 0 0 0 0.08 +- 0.08 1 10

TIGR01382 (1/1) intracellular protease, PfpI family
PF13823 (1/1) Alcohol dehydrogenase GroES-associated
PF13443 (1/1) Cro/C1-type HTH DNA-binding domain
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF01965 (1/1) DJ-1/PfpI family
PF01266 (1/1) FAD dependent oxidoreductase
PF00589 (1/1) Phage integrase family
PF00293 (1/1) NUDIX domain
PF00248 (1/1) Aldo/keto reductase family
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL S-474 326.39 +- 189.61 2 0 1 0 0.05 +- 0.06 2 14

PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF04616 (1/2) Glycosyl hydrolases family 43
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03466 (1/2) LysR substrate binding domain
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00400 (1/2) WD domain, G-beta repeat
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces sp. CFMR 7 660.76 +- 973.30 5 0 1 0 0.05 +- 0.07 5 1

PF00005 (3/5) ABC transporter
Streptomyces sp. M41(2017) 253.04 +- 136.96 2 0 1 1 0.02 +- 0.03 2 13

TIGR03841 (1/2) probable F420-dependent oxidoreductase, Rv3093c family
PF14518 (1/2) Iron-containing redox enzyme
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF04055 (1/2) Radical SAM superfamily
PF01979 (1/2) Amidohydrolase family
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF01037 (1/2) Lrp/AsnC ligand binding domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00202 (1/2) Aminotransferase class-III
PF00082 (1/2) Subtilase family
Streptomyces sp. NEAU-SSA 1 188.57 +- 171.16 3 0 0 0 0.04 +- 0.12 3

No common domains found
Streptomyces sp. Root264 1040.00 +- 390.00 2 0 0 0 0.01 +- 0.00 2 18

PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14435 (1/2) SUKH-4 immunity protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08531 (1/2) Alpha-L-rhamnosidase N-terminal domain
PF05193 (1/2) Peptidase M16 inactive domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01979 (1/2) Amidohydrolase family
PF01937 (1/2) Protein of unknown function DUF89
PF01494 (1/2) FAD binding domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00754 (1/2) F5/8 type C domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00561 (1/2) alpha/beta hydrolase fold
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00005 (1/2) ABC transporter
Streptomyces ruber 207.18 +- 71.87 3 0 1 0 0.03 +- 0.05 3 2

PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF00501 (2/3) AMP-binding enzyme
Streptomyces graminis 62.10 +- 9.22 3 0 0 0 0.04 +- 0.05 3

No common domains found
Streptomyces sp. AW19M42 1677.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 10

TIGR00702 (1/1) YcaO-type kinase domain
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF08007 (1/1) Cupin superfamily protein
PF07812 (1/1) TfuA-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF05193 (1/1) Peptidase M16 inactive domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (1/1) Aminoglycoside 3-N-acetyltransferase
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00326 (1/1) Prolyl oligopeptidase family
Streptomyces cavourensis 326.87 +- 199.57 3 0 2 0 0.05 +- 0.15 3 1

PF00005 (2/3) ABC transporter
Streptomyces bungoensis 2798.82 +- 2661.18 2 0 1 1 0.02 +- 0.03 2 23

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01891 (1/2) amidohydrolase
TIGR00778 (1/2) alkylhydroperoxidase AhpD family core domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13646 (1/2) HEAT repeats
PF08281 (1/2) Sigma-70, region 4
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF04542 (1/2) Sigma-70 region 2
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01966 (1/2) HD domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
Streptomyces fodineus 112.07 +- 0.00 1 0 0 0 0.04 +- 0.07 1 6

PF07730 (1/1) Histidine kinase
PF04444 (1/1) Catechol dioxygenase N terminus
PF00775 (1/1) Dioxygenase
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
Streptomyces sp. ATexAB-D23 1122.78 +- 942.78 2 0 1 2 0.01 +- 0.01 2 16

TIGR00702 (1/2) YcaO-type kinase domain
PF14518 (1/2) Iron-containing redox enzyme
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF08007 (1/2) Cupin superfamily protein
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (1/2) Aminoglycoside 3-N-acetyltransferase
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00326 (1/2) Prolyl oligopeptidase family
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family
Streptomyces sp. NRRL B-11253 99.00 +- 21.00 2 0 0 0 0.09 +- 0.21 2 15

TIGR00229 (1/2) PAS domain S-box protein
PF08795 (1/2) Putative papain-like cysteine peptidase (DUF1796)
PF08448 (1/2) PAS fold
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/2) UTRA domain
PF03098 (1/2) Animal haem peroxidase
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01061 (1/2) ABC-2 type transporter
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (1/2) Universal stress protein family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00199 (1/2) Catalase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter
Streptomyces ipomoeae 91-03 115.78 +- 0.00 1 0 0 0 0.03 +- 0.05 1 8

TIGR00350 (1/1) cell envelope-related function transcriptional attenuator common domain
PF13641 (1/1) Glycosyltransferase like family 2
PF07730 (1/1) Histidine kinase
PF03816 (1/1) Cell envelope-related transcriptional attenuator domain
PF01522 (1/1) Polysaccharide deacetylase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00082 (1/1) Subtilase family
PF00072 (1/1) Response regulator receiver domain
Streptomyces sp. NRRL B-3648 516.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 5

PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00578 (1/1) AhpC/TSA family
PF00005 (1/1) ABC transporter
Streptomyces sp. ADI91-18 641.52 +- 658.99 5 0 2 1 0.02 +- 0.03 5

No common domains found
Streptomyces carminius 133.94 +- 39.39 2 0 0 0 0.02 +- 0.02 2 10

TIGR04362 (1/2) choice-of-anchor C domain
PF17853 (1/2) GGDEF-like domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13185 (1/2) GAF domain
PF07690 (1/2) Major Facilitator Superfamily
PF04862 (1/2) Protein of unknown function (DUF642)
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00106 (1/2) short chain dehydrogenase
Streptomyces sp. NRRL WC-3701 86.67 +- 0.00 1 0 1 1 0.03 +- 0.00 1 3

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
Streptomyces sampsonii 238.40 +- 178.40 2 0 1 0 0.09 +- 0.14 2 32

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF04203 (1/2) Sortase domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF03929 (1/2) PepSY-associated TM region
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter
Streptomyces fulvoviolaceus 180.26 +- 47.24 2 0 0 0 0.06 +- 0.05 2 23

TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF17863 (1/2) AAA lid domain
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13519 (1/2) von Willebrand factor type A domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13365 (1/2) Trypsin-like peptidase domain
PF07726 (1/2) ATPase family associated with various cellular activities (AAA)
PF07584 (1/2) Aerotolerance regulator N-terminal
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01882 (1/2) Protein of unknown function DUF58
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00672 (1/2) HAMP domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00072 (1/2) Response regulator receiver domain
Streptomyces sp. CCM_MD2014 66.86 +- 0.00 1 0 0 0 0.09 +- 0.01 1 9

TIGR02133 (1/1) ribose 5-phosphate isomerase
PF16896 (1/1) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (1/1) Major Facilitator Superfamily
PF03807 (1/1) NADP oxidoreductase coenzyme F420-dependent
PF02734 (1/1) DAK2 domain
PF02733 (1/1) Dak1 domain
PF02502 (1/1) Ribose/Galactose Isomerase
PF01261 (1/1) Xylose isomerase-like TIM barrel
PF00121 (1/1) Triosephosphate isomerase
Streptomyces sp. 69 139.84 +- 26.02 2 0 0 0 0.02 +- 0.01 2 10

PF12833 (1/2) Helix-turn-helix domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03358 (1/2) NADPH-dependent FMN reductase
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (1/2) DJ-1/PfpI family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
Streptomyces sp. BpilaLS-43 715.95 +- 6.45 2 0 2 0 0.01 +- 0.00 2 24

TIGR01891 (1/2) amidohydrolase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (1/2) Zinc-binding dehydrogenase
Embleya hyalina 237.84 +- 99.46 4 0 2 1 0.05 +- 0.12 4 1

PF00155 (2/4) Aminotransferase class I and II
Streptomyces gilvosporeus 126.95 +- 16.38 2 0 0 0 0.03 +- 0.03 2 12

PF13424 (1/2) Tetratricopeptide repeat
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/2) UTRA domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF01925 (1/2) Sulfite exporter TauE/SafE
PF00931 (1/2) NB-ARC domain
PF00664 (1/2) ABC transporter transmembrane region
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces sp. B188M101 468.39 +- 281.28 3 0 2 1 0.07 +- 0.09 3 1

PF00005 (2/3) ABC transporter
Streptomyces tricolor 351.00 +- 0.00 1 0 0 0 0.03 +- 0.03 1 5

PF17964 (1/1) Bacterial Ig domain
PF14246 (1/1) AefR-like transcriptional repressor, C-terminal domain
PF03734 (1/1) L,D-transpeptidase catalytic domain
PF03640 (1/1) Secreted repeat of unknown function
PF00440 (1/1) Bacterial regulatory proteins, tetR family
Streptomyces albidoflavus 28.14 +- 2.30 3 0 0 0 0.08 +- 0.10 3

No common domains found
Streptomyces sp. CNH099 52.75 +- 2.96 2 0 0 0 0.05 +- 0.04 2 10

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR00345 (1/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (1/2) 5TM C-terminal transporter carbon starvation CstA
PF09129 (1/2) Cholesterol oxidase, substrate-binding
PF08281 (1/2) Sigma-70, region 4
PF07995 (1/2) Glucose / Sorbosone dehydrogenase
PF06283 (1/2) Trehalose utilisation
PF02554 (1/2) Carbon starvation protein CstA
PF02374 (1/2) Anion-transporting ATPase
PF01565 (1/2) FAD binding domain
Streptomyces sp. CB02056 349.48 +- 155.41 3 0 2 1 0.05 +- 0.06 3

No common domains found
Streptomyces canus 520.00 +- 0.00 1 0 0 0 0.02 +- 0.00 1 6

PF11794 (1/1) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF03358 (1/1) NADPH-dependent FMN reductase
PF03241 (1/1) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01321 (1/1) Creatinase/Prolidase N-terminal domain
PF00557 (1/1) Metallopeptidase family M24
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme
Streptomyces sp. MK-45 283.41 +- 189.96 3 0 0 0 0.02 +- 0.03 3 1

PF00296 (2/3) Luciferase-like monooxygenase
Streptomyces sp. PgraA7 297.92 +- 135.42 2 0 0 0 0.04 +- 0.10 2 11

PF18029 (1/2) Glyoxalase-like domain
PF11758 (1/2) Aureocin-like type II bacteriocin
PF07690 (1/2) Major Facilitator Superfamily
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
Streptomyces sp. 62 412.94 +- 0.00 1 0 0 0 0.01 +- 0.01 1 8

PF13738 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07722 (1/1) Peptidase C26
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (1/1) Aminotransferase class-III
PF00171 (1/1) Aldehyde dehydrogenase family
PF00120 (1/1) Glutamine synthetase, catalytic domain
PF00107 (1/1) Zinc-binding dehydrogenase
Streptomyces sp. DpondAA-F4 153.78 +- 136.72 3 0 2 0 0.06 +- 0.09 3

No common domains found
Streptomyces clavuligerus 682.50 +- 0.00 1 0 1 0 0.01 +- 0.00 1 17

TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
PF18181 (1/1) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (1/1) Dimerisation domain
PF14015 (1/1) Protein of unknown function (DUF4231)
PF13692 (1/1) Glycosyl transferases group 1
PF13676 (1/1) TIR domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13292 (1/1) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (1/1) Maltose acetyltransferase
PF11941 (1/1) Domain of unknown function (DUF3459)
PF07728 (1/1) AAA domain (dynein-related subfamily)
PF05729 (1/1) NACHT domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00202 (1/1) Aminotransferase class-III
PF00132 (1/1) Bacterial transferase hexapeptide (six repeats)
Streptomyces sp. GBA 94-10 127.02 +- 0.00 1 0 1 0 0.06 +- 0.16 1 19

TIGR02412 (1/1) aminopeptidase N
TIGR01686 (1/1) FkbH domain
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (1/1) ERAP1-like C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF02274 (1/1) Amidinotransferase
PF02195 (1/1) ParB-like nuclease domain
PF01433 (1/1) Peptidase family M1 domain
PF01266 (1/1) FAD dependent oxidoreductase
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00550 (1/1) Phosphopantetheine attachment site
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
Streptomyces sp. MH60 90.00 +- 0.00 1 0 0 0 0.03 +- 0.04 1 7

PF02817 (1/1) e3 binding domain
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00557 (1/1) Metallopeptidase family M24
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Streptomyces klenkii 785.74 +- 636.85 4 0 3 1 0.01 +- 0.01 4 1

PF00067 (2/4) Cytochrome P450
Streptomyces sp. 1 1824.43 +- 276.43 2 0 1 1 0.01 +- 0.00 2 21

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14081 (1/2) Domain of unknown function (DUF4262)
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (1/2) SAF domain
PF07811 (1/2) TadE-like protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01476 (1/2) LysM domain
PF01381 (1/2) Helix-turn-helix
PF00881 (1/2) Nitroreductase family
PF00664 (1/2) ABC transporter transmembrane region
PF00482 (1/2) Type II secretion system (T2SS), protein F
PF00437 (1/2) Type II/IV secretion system protein
PF00364 (1/2) Biotin-requiring enzyme
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter
Streptomyces venezuelae 2282.22 +- 2553.69 3 0 1 1 0.01 +- 0.01 3

No common domains found
Streptomyces sp. ADI95-17 209.39 +- 101.23 3 0 2 0 0.03 +- 0.05 3

No common domains found
Streptomyces sp. HGB0020 125.85 +- 66.96 3 0 0 0 0.04 +- 0.14 3

No common domains found
Streptomyces cellulosae 593.03 +- 478.29 6 0 0 0 0.04 +- 0.14 6 1

PF13561 (3/6) Enoyl-(Acyl carrier protein) reductase
Streptomyces sp. AcH 505 505.38 +- 619.18 5 0 1 0 0.03 +- 0.11 5

No common domains found
Streptomyces sp. NRRL S-1314 164.68 +- 0.00 1 0 1 1 0.06 +- 0.05 1 6

PF05147 (1/1) Lanthionine synthetase C-like protein
PF01810 (1/1) LysE type translocator
PF00877 (1/1) NlpC/P60 family
PF00664 (1/1) ABC transporter transmembrane region
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter
Streptomyces showdoensis 1118.15 +- 743.00 3 0 0 0 0.02 +- 0.02 3

No common domains found
Streptomyces sp. SolWspMP-5a-2 1949.71 +- 2474.96 4 0 1 1 0.02 +- 0.04 4 1

PF00005 (3/4) ABC transporter
Streptomyces sp. DvalAA-19 206.72 +- 39.19 3 0 1 0 0.07 +- 0.15 3 2

PF00005 (3/3) ABC transporter
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase
Streptomyces sp. CB02115 87.41 +- 0.00 1 0 1 0 0.05 +- 0.14 1 12

TIGR01760 (1/1) phage tail tape measure protein, TP901 family, core region
TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF16945 (1/1) Putative lactococcus lactis phage r1t holin
PF13830 (1/1) Domain of unknown function (DUF4192)
PF10145 (1/1) Phage-related minor tail protein
PF05709 (1/1) Phage tail protein
PF04883 (1/1) Bacteriophage HK97-gp10, putative tail-component
PF03837 (1/1) RecT family
PF02384 (1/1) N-6 DNA Methylase
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00216 (1/1) Bacterial DNA-binding protein
PF00145 (1/1) C-5 cytosine-specific DNA methylase
Streptomyces californicus 444.11 +- 290.54 2 0 1 0 0.04 +- 0.02 2 25

PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (1/2) Major Facilitator Superfamily
PF04909 (1/2) Amidohydrolase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/2) Coenzyme A transferase
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces nodosus 1214.93 +- 1193.07 2 0 0 0 0.03 +- 0.05 2 22

TIGR01910 (1/2) peptidase, ArgE/DapE family
PF17853 (1/2) GGDEF-like domain
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13516 (1/2) Leucine Rich repeat
PF13203 (1/2) Putative metallopeptidase domain
PF09967 (1/2) VWA-like domain (DUF2201)
PF09084 (1/2) NMT1/THI5 like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF06094 (1/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF04909 (1/2) Amidohydrolase
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01979 (1/2) Amidohydrolase family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00676 (1/2) Dehydrogenase E1 component
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter
Streptomyces xinghaiensis 153.06 +- 9.30 3 0 2 1 0.06 +- 0.09 3 1

PF13419 (2/3) Haloacid dehalogenase-like hydrolase
Streptomyces sp. NRRL WC-3725 280.36 +- 169.38 3 0 1 1 0.02 +- 0.04 3

No common domains found
Streptomyces sp. 1114.5 445.11 +- 328.89 2 0 0 1 0.07 +- 0.19 2 31

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR02009 (1/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (1/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (1/2) Glyoxalase-like domain
PF17866 (1/2) AAA lid domain
PF14436 (1/2) Bacterial EndoU nuclease
PF13560 (1/2) Helix-turn-helix domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF13229 (1/2) Right handed beta helix region
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (1/2) Cupin domain
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04055 (1/2) Radical SAM superfamily
PF03816 (1/2) Cell envelope-related transcriptional attenuator domain
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (1/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01061 (1/2) ABC-2 type transporter
PF00717 (1/2) Peptidase S24-like
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
Streptomyces sp. WAC 05379 516.00 +- 0.00 1 0 0 1 0.01 +- 0.00 1 7

TIGR00702 (1/1) YcaO-type kinase domain
PF18029 (1/1) Glyoxalase-like domain
PF13489 (1/1) Methyltransferase domain
PF13231 (1/1) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (1/1) TfuA-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
Streptomyces sp. B226SN101 320.87 +- 284.91 3 0 2 2 0.04 +- 0.07 3 3

PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter
Streptomyces sp. WAC 01529 438.75 +- 211.25 2 0 1 1 0.01 +- 0.01 2 18

TIGR00348 (1/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (1/2) SWI2/SNF2 ATPase
PF17820 (1/2) PDZ domain
PF14659 (1/2) Phage integrase, N-terminal SAM-like domain
PF13661 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13649 (1/2) Methyltransferase domain
PF13304 (1/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (1/2) HsdM N-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF05729 (1/2) NACHT domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04339 (1/2) Peptidogalycan biosysnthesis/recognition
PF04313 (1/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF04055 (1/2) Radical SAM superfamily
PF02384 (1/2) N-6 DNA Methylase
PF01863 (1/2) Protein of unknown function DUF45
PF01420 (1/2) Type I restriction modification DNA specificity domain
PF00589 (1/2) Phage integrase family
Streptomyces kanamyceticus 1105.00 +- 325.00 2 0 1 2 0.01 +- 0.00 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (2/2) CPBP intramembrane metalloprotease
PF00881 (2/2) Nitroreductase family
PF00296 (2/2) Luciferase-like monooxygenase
PF04055 (1/2) Radical SAM superfamily
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00440 (1/2) Bacterial regulatory proteins, tetR family
Streptomyces albus 67.14 +- 7.14 2 0 0 0 0.04 +- 0.05 2 6

PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
Streptomyces sp. st115 1322.72 +- 1257.28 2 0 1 1 0.04 +- 0.07 2 16

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF12697 (1/2) Alpha/beta hydrolase family
PF08002 (1/2) Protein of unknown function (DUF1697)
PF07730 (1/2) Histidine kinase
PF05922 (1/2) Peptidase inhibitor I9
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00072 (1/2) Response regulator receiver domain
Streptomyces xanthophaeus 769.06 +- 838.09 3 0 2 1 0.05 +- 0.18 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces griseus 41.61 +- 0.00 1 0 1 0 0.10 +- 0.09 1 4

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (1/1) Major Facilitator Superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00067 (1/1) Cytochrome P450
Streptomyces sp. CNT360 650.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 7

PF16113 (1/1) Enoyl-CoA hydratase/isomerase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09339 (1/1) IclR helix-turn-helix domain
PF02515 (1/1) CoA-transferase family III
PF01614 (1/1) Bacterial transcriptional regulator
PF01144 (1/1) Coenzyme A transferase
PF00501 (1/1) AMP-binding enzyme
Streptomyces sp. M2 240.80 +- 0.00 1 0 0 0 0.03 +- 0.04 1 9

TIGR03083 (1/1) uncharacterized Actinobacterial protein TIGR03083
PF17964 (1/1) Bacterial Ig domain
PF11716 (1/1) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (1/1) UTRA domain
PF07398 (1/1) MDMPI C-terminal domain
PF03734 (1/1) L,D-transpeptidase catalytic domain
PF01381 (1/1) Helix-turn-helix
PF00931 (1/1) NB-ARC domain
PF00392 (1/1) Bacterial regulatory proteins, gntR family
Streptomyces celluloflavus 803.12 +- 586.07 4 0 0 0 0.01 +- 0.02 4 1

PF00891 (2/4) O-methyltransferase domain
Streptomyces sp. Alain-F2R5 264.83 +- 196.42 2 0 0 1 0.05 +- 0.07 2 37

TIGR03812 (1/2) tyrosine decarboxylase MnfA
PF17755 (1/2) UvrA DNA-binding domain
PF16861 (1/2) Carbamoyltransferase C-terminus
PF16169 (1/2) Domain of unknown function (DUF4872)
PF14399 (1/2) Butirosin biosynthesis protein H, N-terminal
PF13847 (1/2) Methyltransferase domain
PF13671 (1/2) AAA domain
PF13649 (1/2) Methyltransferase domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12833 (1/2) Helix-turn-helix domain
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (1/2) DNA alkylation repair enzyme
PF08241 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (1/2) Radical SAM superfamily
PF03745 (1/2) Domain of unknown function (DUF309)
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (1/2) Carbamoyltransferase N-terminus
PF02310 (1/2) B12 binding domain
PF02195 (1/2) ParB-like nuclease domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01497 (1/2) Periplasmic binding protein
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01061 (1/2) ABC-2 type transporter
PF01032 (1/2) FecCD transport family
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00501 (1/2) AMP-binding enzyme
PF00384 (1/2) Molybdopterin oxidoreductase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00293 (1/2) NUDIX domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (1/2) ABC transporter
Streptomyces rimosus subsp. rimosus 61.58 +- 0.00 1 0 0 0 0.05 +- 0.03 1 4

PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/1) UTRA domain
PF01925 (1/1) Sulfite exporter TauE/SafE
PF00392 (1/1) Bacterial regulatory proteins, gntR family
Streptomyces fulvoviridis 541.80 +- 284.97 3 0 1 1 0.01 +- 0.01 3 1

PF00501 (2/3) AMP-binding enzyme
Streptomyces sp. NRRL B-24085 910.00 +- 650.00 2 0 1 0 0.01 +- 0.00 2 12

TIGR01840 (1/2) esterase, PHB depolymerase family
PF13365 (1/2) Trypsin-like peptidase domain
PF13191 (1/2) AAA ATPase domain
PF10503 (1/2) Esterase PHB depolymerase
PF08007 (1/2) Cupin superfamily protein
PF03412 (1/2) Peptidase C39 family
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00400 (1/2) WD domain, G-beta repeat
PF00005 (1/2) ABC transporter
Streptomyces sp. 3211 387.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 6

PF13459 (1/1) 4Fe-4S single cluster domain
PF10589 (1/1) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/1) TAP-like protein
PF03640 (1/1) Secreted repeat of unknown function
PF01512 (1/1) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (1/1) alpha/beta hydrolase fold
Streptomyces sp. S8 1137.27 +- 1559.20 3 0 2 0 0.02 +- 0.04 3 4

TIGR01525 (2/3) heavy metal translocating P-type ATPase
PF00702 (2/3) haloacid dehalogenase-like hydrolase
PF00403 (2/3) Heavy-metal-associated domain
PF00122 (2/3) E1-E2 ATPase
Streptomyces sp. NBRC 110027 406.94 +- 179.37 4 0 1 1 0.02 +- 0.04 4 2

PF07690 (2/4) Major Facilitator Superfamily
PF00069 (2/4) Protein kinase domain
Streptomyces sp. st77 585.00 +- 65.00 2 0 1 1 0.01 +- 0.01 2 9

PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter
Streptomyces griseorubiginosus 43.00 +- 0.00 1 0 0 0 0.07 +- 0.09 1 4

PF13649 (1/1) Methyltransferase domain
PF07730 (1/1) Histidine kinase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
Streptomyces lydicus 142.38 +- 74.91 4 0 1 1 0.06 +- 0.08 4 2

PF00005 (3/4) ABC transporter
PF00664 (2/4) ABC transporter transmembrane region
Streptomyces bacillaris 199.06 +- 117.79 2 0 2 0 0.07 +- 0.04 2 25

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12840 (1/2) Helix-turn-helix domain
PF12697 (1/2) Alpha/beta hydrolase family
PF12679 (1/2) ABC-2 family transporter protein
PF10400 (1/2) Virulence activator alpha C-term
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF04909 (1/2) Amidohydrolase
PF03551 (1/2) Transcriptional regulator PadR-like family
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01756 (1/2) Acyl-CoA oxidase
PF01144 (1/2) Coenzyme A transferase
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00294 (1/2) pfkB family carbohydrate kinase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter
Streptomyces rishiriensis 47.39 +- 0.00 1 0 0 0 0.06 +- 0.05 1 3

PF07690 (1/1) Major Facilitator Superfamily
PF02031 (1/1) Streptomyces extracellular neutral proteinase (M7) family
PF00069 (1/1) Protein kinase domain
Streptomyces sp. 2114.2 181.01 +- 0.00 1 0 1 1 0.06 +- 0.03 1 13

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family
Streptomyces europaeiscabiei 31.21 +- 0.00 1 0 0 0 0.10 +- 0.06 1 9

PF13478 (1/1) XdhC Rossmann domain
PF09339 (1/1) IclR helix-turn-helix domain
PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (1/1) XdhC and CoxI family
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
PF00111 (1/1) 2Fe-2S iron-sulfur cluster binding domain
Streptomyces rimosus subsp. rimosus 42.62 +- 5.76 2 0 1 1 0.06 +- 0.00 2 6

PF13471 (1/2) Transglutaminase-like superfamily
PF12833 (1/2) Helix-turn-helix domain
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02311 (1/2) AraC-like ligand binding domain
PF00733 (1/2) Asparagine synthase
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
Streptomyces mobaraensis NBRC 13819 = DSM 40847 151.67 +- 0.00 1 0 0 0 0.03 +- 0.04 1 5

PF14016 (1/1) Protein of unknown function (DUF4232)
PF07690 (1/1) Major Facilitator Superfamily
PF07301 (1/1) Protein of unknown function (DUF1453)
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF01047 (1/1) MarR family
Streptomyces flavidovirens DSM 40150 893.08 +- 0.00 1 0 0 0 0.01 +- 0.01 1 7

PF11953 (1/1) Domain of unknown function (DUF3470)
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02597 (1/1) ThiS family
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (1/1) 4Fe-4S binding domain
Streptomyces sp. 46 560.44 +- 614.96 3 0 0 0 0.03 +- 0.06 3

No common domains found
Streptomyces albidoflavus 258.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 2

PF01757 (1/1) Acyltransferase family
PF00248 (1/1) Aldo/keto reductase family
Streptomyces sp. NRRL B-24484 442.64 +- 286.14 4 0 2 2 0.02 +- 0.04 4 9

TIGR03882 (2/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/4) SagB-type dehydrogenase domain
TIGR03604 (2/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF03412 (2/4) Peptidase C39 family
PF02624 (2/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/4) Nitroreductase family
PF00664 (2/4) ABC transporter transmembrane region
PF00067 (2/4) Cytochrome P450
PF00005 (2/4) ABC transporter
Streptomyces sp. AcE210 220.90 +- 280.81 5 0 0 0 0.05 +- 0.08 5

No common domains found
Streptomyces sp. ICC1 350.67 +- 183.60 3 0 1 0 0.04 +- 0.17 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces atratus 254.47 +- 106.43 3 0 2 1 0.03 +- 0.04 3

No common domains found
Streptomyces sp. NRRL B-1381 169.48 +- 124.61 2 0 1 0 0.08 +- 0.17 2 29

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13796 (1/2) Putative sensor
PF13578 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF06259 (1/2) Alpha/beta hydrolase
PF03621 (1/2) MbtH-like protein
PF02687 (1/2) FtsX-like permease family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01757 (1/2) Acyltransferase family
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter
Streptomyces bicolor 157.98 +- 7.98 2 0 1 0 0.04 +- 0.05 2 11

PF13416 (1/2) Bacterial extracellular solute-binding protein
PF05426 (1/2) Alginate lyase
PF05345 (1/2) Putative Ig domain
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF04073 (1/2) Aminoacyl-tRNA editing domain
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
PF00892 (1/2) EamA-like transporter family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00464 (1/2) Serine hydroxymethyltransferase
PF00135 (1/2) Carboxylesterase family
PF00082 (1/2) Subtilase family
Streptomyces sp. Act143 1789.88 +- 2544.43 4 0 0 0 0.01 +- 0.00 4

No common domains found
Streptomyces flavovariabilis 316.97 +- 269.70 2 0 1 0 0.03 +- 0.03 2 20

TIGR01415 (1/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08223 (1/2) PaaX-like protein C-terminal domain
PF07848 (1/2) PaaX-like protein
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF06339 (1/2) Ectoine synthase
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (1/2) B12 binding domain
PF01841 (1/2) Transglutaminase-like superfamily
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
Streptomyces lunaelactis 273.00 +- 117.00 2 0 0 0 0.01 +- 0.01 2 9

PF09851 (1/2) Short C-terminal domain
PF04972 (1/2) BON domain
PF01061 (1/2) ABC-2 type transporter
PF00582 (1/2) Universal stress protein family
PF00571 (1/2) CBS domain
PF00498 (1/2) FHA domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
Streptomyces sparsogenes 688.00 +- 0.00 1 0 1 1 0.01 +- 0.01 1 10

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03704 (1/1) Bacterial transcriptional activator domain
PF03412 (1/1) Peptidase C39 family
PF03372 (1/1) Endonuclease/Exonuclease/phosphatase family
PF00664 (1/1) ABC transporter transmembrane region
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter
Streptomyces griseus subsp. rhodochrous 228.18 +- 23.37 2 0 1 1 0.04 +- 0.06 2 22

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01061 (1/2) ABC-2 type transporter
PF00931 (1/2) NB-ARC domain
PF00881 (1/2) Nitroreductase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter
Streptomyces sp. HG99 483.75 +- 0.00 1 0 0 0 0.01 +- 0.01 1 4

PF02225 (1/1) PA domain
PF01978 (1/1) Sugar-specific transcriptional regulator TrmB
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00082 (1/1) Subtilase family
Streptomyces sp. MA5143a 189.09 +- 0.00 1 0 0 0 0.04 +- 0.01 1 14

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
Streptomyces sp. M7 187.63 +- 121.22 5 0 0 0 0.03 +- 0.06 5

No common domains found
Streptomyces sp. NRRL S-475 547.34 +- 387.13 2 0 0 1 0.03 +- 0.02 2 31

PF00005 (2/2) ABC transporter
TIGR03812 (1/2) tyrosine decarboxylase MnfA
PF17755 (1/2) UvrA DNA-binding domain
PF16861 (1/2) Carbamoyltransferase C-terminus
PF16169 (1/2) Domain of unknown function (DUF4872)
PF14399 (1/2) Butirosin biosynthesis protein H, N-terminal
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (1/2) DNA alkylation repair enzyme
PF08402 (1/2) TOBE domain
PF08386 (1/2) TAP-like protein
PF08241 (1/2) Methyltransferase domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (1/2) Radical SAM superfamily
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (1/2) Carbamoyltransferase N-terminus
PF02310 (1/2) B12 binding domain
PF02195 (1/2) ParB-like nuclease domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01061 (1/2) ABC-2 type transporter
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00384 (1/2) Molybdopterin oxidoreductase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00171 (1/2) Aldehyde dehydrogenase family
Streptomyces viridosporus T7A 71.09 +- 0.00 1 0 0 0 0.07 +- 0.11 1 8

PF12450 (1/1) von Willebrand factor
PF12034 (1/1) Domain of unknown function (DUF3520)
PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00501 (1/1) AMP-binding enzyme
PF00092 (1/1) von Willebrand factor type A domain
PF00005 (1/1) ABC transporter
Streptomyces cyaneus 707.69 +- 1054.35 6 0 1 0 0.02 +- 0.03 6

No common domains found
Streptomyces sp. W1SF4 427.13 +- 281.52 5 0 5 2 0.02 +- 0.03 5

No common domains found
Streptomyces sp. PanSC19 508.03 +- 321.03 4 0 0 1 0.02 +- 0.05 4 2

PF07690 (3/4) Major Facilitator Superfamily
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme
Streptomyces sp. 3212.2 902.09 +- 1203.88 4 0 2 0 0.05 +- 0.17 4 9

TIGR01733 (2/4) amino acid adenylation domain
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF00975 (2/4) Thioesterase domain
PF00903 (2/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/4) Condensation domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00296 (2/4) Luciferase-like monooxygenase
Streptomyces bottropensis ATCC 25435 3120.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 13

TIGR04245 (1/1) N-acyltransferase NodA
TIGR04243 (1/1) chitooligosaccharide deacetylase NodB
TIGR04242 (1/1) chitooligosaccharide synthase NodC
TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02474 (1/1) Nodulation protein A (NodA)
PF01522 (1/1) Polysaccharide deacetylase
PF01061 (1/1) ABC-2 type transporter
PF00535 (1/1) Glycosyl transferase family 2
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/1) ABC transporter
Streptomyces globisporus 63.00 +- 0.00 1 0 0 0 0.05 +- 0.02 1 5

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
Streptomyces caatingaensis 167.14 +- 0.00 1 0 1 0 0.04 +- 0.08 1 12

TIGR01733 (1/1) amino acid adenylation domain
PF17645 (1/1) Arylmalonate decarboxylase
PF11695 (1/1) Domain of unknown function (DUF3291)
PF08962 (1/1) Domain of unknown function (DUF1876)
PF08386 (1/1) TAP-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF01361 (1/1) Tautomerase enzyme
PF00975 (1/1) Thioesterase domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00144 (1/1) Beta-lactamase
Streptomyces sp. ETH9427 103.20 +- 0.00 1 0 0 0 0.02 +- 0.01 1 2

TIGR03296 (1/1) M6 family metalloprotease domain
PF04672 (1/1) S-adenosyl methyltransferase
Streptomyces olivoreticuli subsp. olivoreticuli 360.33 +- 142.21 7 0 4 0 0.03 +- 0.09 7

No common domains found
Streptomyces olivaceus 270.40 +- 0.00 1 0 1 1 0.09 +- 0.26 1 11

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13601 (1/1) Winged helix DNA-binding domain
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04820 (1/1) Tryptophan halogenase
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter
Streptomyces sp. PAMC 26508 404.44 +- 0.00 1 0 1 1 0.02 +- 0.01 1 7

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF03466 (1/1) LysR substrate binding domain
PF02310 (1/1) B12 binding domain
PF00733 (1/1) Asparagine synthase
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces griseolus 109.97 +- 12.47 2 0 0 1 0.06 +- 0.04 2 12

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
Streptomyces sp. MUSC 125 650.00 +- 0.00 1 0 1 1 0.01 +- 0.00 1 6

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase
Streptomyces pharetrae CZA14 1373.12 +- 0.00 1 0 1 1 0.01 +- 0.00 1 23

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR03494 (1/1) salicylate synthase
TIGR02185 (1/1) putative ECF transporter S component, Trep_Strep family
TIGR01733 (1/1) amino acid adenylation domain
TIGR01643 (1/1) YD repeat (two copies)
TIGR01536 (1/1) asparagine synthase (glutamine-hydrolyzing)
TIGR01443 (1/1) intein C-terminal splicing region
PF13537 (1/1) Glutamine amidotransferase domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09605 (1/1) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (1/1) Pretoxin HINT domain
PF05593 (1/1) RHS Repeat
PF03704 (1/1) Bacterial transcriptional activator domain
PF02361 (1/1) Cobalt transport protein
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00733 (1/1) Asparagine synthase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00425 (1/1) chorismate binding enzyme
PF00005 (1/1) ABC transporter
Streptomyces sp. ScaeMP-6W 119.08 +- 0.00 1 0 0 0 0.03 +- 0.03 1 3

PF03067 (1/1) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (1/1) SPFH domain / Band 7 family
PF00877 (1/1) NlpC/P60 family
Streptomyces peucetius 50.48 +- 0.00 1 0 0 0 0.06 +- 0.04 1 4

PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/1) UTRA domain
PF01925 (1/1) Sulfite exporter TauE/SafE
PF00392 (1/1) Bacterial regulatory proteins, gntR family
Streptomyces xanthophaeus 519.87 +- 494.82 3 0 2 1 0.05 +- 0.19 3 1

PF07690 (2/3) Major Facilitator Superfamily
Streptomyces scabiei 286.67 +- 0.00 1 0 0 0 0.03 +- 0.00 1 7

PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF05025 (1/1) RbsD / FucU transport protein family
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00005 (1/1) ABC transporter
Streptomyces sp. NRRL F-5123 390.00 +- 216.67 2 0 0 0 0.01 +- 0.01 2 10

PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF01988 (1/2) VIT family
PF01344 (1/2) Kelch motif
PF01169 (1/2) Uncharacterized protein family UPF0016
PF01012 (1/2) Electron transfer flavoprotein domain
PF00766 (1/2) Electron transfer flavoprotein FAD-binding domain
PF00553 (1/2) Cellulose binding domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
Streptomyces violens 658.67 +- 485.33 2 0 2 1 0.04 +- 0.04 2 15

TIGR00710 (1/2) drug resistance transporter, Bcr/CflA subfamily
PF07690 (1/2) Major Facilitator Superfamily
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF03737 (1/2) Aldolase/RraA
PF03466 (1/2) LysR substrate binding domain
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01361 (1/2) Tautomerase enzyme
PF00994 (1/2) Probable molybdopterin binding domain
PF00890 (1/2) FAD binding domain
PF00881 (1/2) Nitroreductase family
PF00682 (1/2) HMGL-like
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
Streptomyces albulus CCRC 11814 501.22 +- 712.73 6 0 3 1 0.02 +- 0.05 6

No common domains found
Streptomyces sp. CS065A 60.67 +- 17.33 2 0 0 0 0.04 +- 0.05 2 10

PF17866 (1/2) AAA lid domain
PF13229 (1/2) Right handed beta helix region
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (1/2) Putative Ig domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00082 (1/2) Subtilase family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
Streptomyces anulatus 107.32 +- 81.88 2 0 0 0 0.04 +- 0.08 2 14

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF08031 (1/2) Berberine and berberine like
PF07179 (1/2) SseB protein N-terminal domain
PF05593 (1/2) RHS Repeat
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF03527 (1/2) RHS protein
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01565 (1/2) FAD binding domain
PF00293 (1/2) NUDIX domain
Streptomyces clavuligerus 239.77 +- 211.73 2 0 1 0 0.03 +- 0.06 2 21

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF18181 (1/2) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (1/2) Dimerisation domain
PF14015 (1/2) Protein of unknown function (DUF4231)
PF13692 (1/2) Glycosyl transferases group 1
PF13676 (1/2) TIR domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13292 (1/2) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (1/2) Maltose acetyltransferase
PF11941 (1/2) Domain of unknown function (DUF3459)
PF08386 (1/2) TAP-like protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF05729 (1/2) NACHT domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF02388 (1/2) FemAB family
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00202 (1/2) Aminotransferase class-III
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
Streptomyces kebangsaanensis 204.63 +- 0.00 1 0 1 1 0.07 +- 0.09 1 17

TIGR03892 (1/1) thiazolylpeptide-type bacteriocin precursor
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/1) amidohydrolase
TIGR01552 (1/1) prevent-host-death family protein
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02604 (1/1) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01850 (1/1) PIN domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00582 (1/1) Universal stress protein family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter
Streptomyces sp. YIM 130001 328.14 +- 84.39 2 0 0 0 0.03 +- 0.04 2 26

TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (1/2) Rrf2 family protein
PF18364 (1/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (1/2) Thioredoxin
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF04309 (1/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (1/2) Transcriptional regulator
PF01909 (1/2) Nucleotidyltransferase domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01565 (1/2) FAD binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (1/2) Molybdopterin oxidoreductase
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter
Streptomyces sp. NRRL F-5755 162.04 +- 97.96 2 0 1 0 0.05 +- 0.04 2 16

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (1/2) amidohydrolase
TIGR00843 (1/2) benzoate transporter
PF13454 (1/2) FAD-NAD(P)-binding
PF13424 (1/2) Tetratricopeptide repeat
PF03594 (1/2) Benzoate membrane transport protein
PF03412 (1/2) Peptidase C39 family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (1/2) NB-ARC domain
PF00664 (1/2) ABC transporter transmembrane region
PF00535 (1/2) Glycosyl transferase family 2
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00005 (1/2) ABC transporter
Streptomyces sp. TRM44457 37.68 +- 12.32 2 0 0 0 0.06 +- 0.09 2 8

PF13673 (1/2) Acetyltransferase (GNAT) domain
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF05977 (1/2) Transmembrane secretion effector
PF05013 (1/2) N-formylglutamate amidohydrolase
PF02225 (1/2) PA domain
PF00248 (1/2) Aldo/keto reductase family
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain
Streptomyces sp. TLI_55 176.37 +- 179.33 4 0 0 1 0.05 +- 0.04 4

No common domains found
Streptomyces sp. ACT-1 1219.64 +- 0.00 1 0 0 0 0.01 +- 0.00 1 14

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17645 (1/1) Arylmalonate decarboxylase
PF13489 (1/1) Methyltransferase domain
PF09339 (1/1) IclR helix-turn-helix domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF04978 (1/1) Protein of unknown function (DUF664)
PF02426 (1/1) Muconolactone delta-isomerase
PF01614 (1/1) Bacterial transcriptional regulator
PF01593 (1/1) Flavin containing amine oxidoreductase
PF01244 (1/1) Membrane dipeptidase (Peptidase family M19)
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (1/1) Aldehyde dehydrogenase family
PF00005 (1/1) ABC transporter
Streptomyces sp. DH-12 61.43 +- 0.00 1 0 1 0 0.07 +- 0.11 1 13

TIGR01733 (1/1) amino acid adenylation domain
TIGR01720 (1/1) non-ribosomal peptide synthase domain TIGR01720
TIGR01263 (1/1) 4-hydroxyphenylpyruvate dioxygenase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08242 (1/1) Methyltransferase domain
PF03621 (1/1) MbtH-like protein
PF01070 (1/1) FMN-dependent dehydrogenase
PF00975 (1/1) Thioesterase domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00155 (1/1) Aminotransferase class I and II
Streptomyces sp. CB02058 34.67 +- 0.00 1 0 0 0 0.06 +- 0.04 1 2

PF09995 (1/1) Uncharacterized protein conserved in bacteria (DUF2236)
PF00171 (1/1) Aldehyde dehydrogenase family
Streptomyces glaucescens 154.80 +- 0.00 1 0 1 0 0.09 +- 0.20 1 21

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR03494 (1/1) salicylate synthase
TIGR02185 (1/1) putative ECF transporter S component, Trep_Strep family
TIGR01733 (1/1) amino acid adenylation domain
TIGR01643 (1/1) YD repeat (two copies)
TIGR01443 (1/1) intein C-terminal splicing region
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09605 (1/1) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (1/1) Pretoxin HINT domain
PF05593 (1/1) RHS Repeat
PF03704 (1/1) Bacterial transcriptional activator domain
PF02361 (1/1) Cobalt transport protein
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00668 (1/1) Condensation domain
PF00664 (1/1) ABC transporter transmembrane region
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00425 (1/1) chorismate binding enzyme
PF00005 (1/1) ABC transporter
Streptomyces sp. BoleA5 109.42 +- 37.43 4 0 1 0 0.05 +- 0.11 4

No common domains found
Streptomyces sp. XY413 1935.00 +- 0.00 1 0 0 0 0.01 +- 0.00 1 15

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter
Streptomyces sp. VMFN-G11Ma 3776.18 +- 2873.18 2 0 0 0 0.01 +- 0.01 2 27

PF01381 (2/2) Helix-turn-helix
TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17964 (1/2) Bacterial Ig domain
PF17853 (1/2) GGDEF-like domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13378 (1/2) Enolase C-terminal domain-like
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10400 (1/2) Virulence activator alpha C-term
PF08667 (1/2) BetR domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07702 (1/2) UTRA domain
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF07398 (1/2) MDMPI C-terminal domain
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF03551 (1/2) Transcriptional regulator PadR-like family
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02687 (1/2) FtsX-like permease family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00931 (1/2) NB-ARC domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00144 (1/2) Beta-lactamase
PF00005 (1/2) ABC transporter
Streptomyces lydicus 167.74 +- 0.00 1 0 0 0 0.05 +- 0.05 1 6

PF16859 (1/1) Tetracyclin repressor-like, C-terminal domain
PF03992 (1/1) Antibiotic biosynthesis monooxygenase
PF00664 (1/1) ABC transporter transmembrane region
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00248 (1/1) Aldo/keto reductase family
PF00005 (1/1) ABC transporter
Streptomyces mirabilis 387.85 +- 395.48 5 0 1 1 0.03 +- 0.04 5

No common domains found
Streptomyces rimosus subsp. rimosus 69.28 +- 38.00 3 0 2 1 0.08 +- 0.08 3

No common domains found
Streptomyces sp. 2231.1 463.33 +- 499.87 3 0 1 1 0.04 +- 0.14 3 1

PF12728 (2/3) Helix-turn-helix domain